prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Stfa1 in Microglial Cell Line causally result in response to virus?
| 0
| 1,438
|
Knockout
|
Stfa1
|
response to virus
|
Microglial Cell Line
|
Gene: Stfa1 (stefin A1)
Type: protein-coding
Summary: Enables endopeptidase inhibitor activity. Acts upstream of or within negative regulation of endopeptidase activity. Located in cytoplasm. Human ortholog(s) of this gene implicated in peeling skin syndrome 4. Orthologous to human CSTA (cystatin A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell-cell adhesion, keratinocyte differentiation, negative regulation of proteolysis; MF: cysteine-type endopeptidase inhibitor activity, endopeptidase inhibitor activity, peptidase inhibitor activity, protease binding; CC: cornified envelope, cytoplasm, cytosol, extracellular space, nucleoplasm, peptidase inhibitor complex
Pathways:
UniProt: P35175
Entrez ID: 20861
|
Does Knockout of Bank1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Bank1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Bank1 (B cell scaffold protein with ankyrin repeats 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, negative regulation of B cell activation, negative regulation of interleukin-6 production, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of translational initiation, positive regulation of MAPK cascade, regulation of immune system process, regulation of protein metabolic process, response to bacterium, signal transduction; MF: phospholipase binding, protease binding, protein binding, protein tyrosine kinase binding, signaling adaptor activity, signaling receptor binding; CC: perinuclear region of cytoplasm
Pathways:
UniProt: Q80VH0
Entrez ID: 242248
|
Does Knockout of Aamp in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Aamp
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Aamp (angio-associated migratory protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cell surface, cytoplasm, intercellular bridge, microtubule cytoskeleton, plasma membrane
Pathways: Hemostasis, Immune System, Innate Immune System, NOD1/2 Signaling Pathway, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Platelet activation, signaling and aggregation, Signal Transduction, Signal amplification, Signaling by EGFR, Signaling by Receptor Tyrosine Kinases, Thromboxane signalling through TP receptor
UniProt: J3QN89, Q3TJ22, A0A087WR11, A0A087WNM5
Entrez ID: 227290
|
Does Knockout of Il13ra1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Il13ra1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Il13ra1 (interleukin 13 receptor, alpha 1)
Type: protein-coding
Summary: This gene encodes a transmembrane protein that complexes with interleukin 4 receptor alpha (IL4RA) to form a functional receptor for interleukin-13. Signalling through this pathway mediates allergy response and occurs during bronchial asthma. [provided by RefSeq, May 2015].
Gene Ontology: BP: cytokine-mediated signaling pathway, positive regulation of immunoglobulin production; MF: cytokine binding, cytokine receptor activity, interleukin-13 receptor activity; CC: external side of plasma membrane, membrane, receptor complex
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Interleukin-4 and Interleukin-13 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Signaling by Interleukins
UniProt: O09030
Entrez ID: 16164
|
Does Knockout of Fem1b in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Fem1b
|
cell cycle progression
|
breast epithelium
|
Gene: Fem1b (fem 1 homolog b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, branching involved in prostate gland morphogenesis, developmental process involved in reproduction, epithelial cell maturation, epithelial cell maturation involved in prostate gland development, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination, regulation of DNA damage checkpoint, regulation of extrinsic apoptotic signaling pathway via death domain receptors, ubiquitin-dependent protein catabolic process via the C-end degron rule pathway; MF: death receptor binding, protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, cytoplasm, cytosol, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9Z2G0
Entrez ID: 14155
|
Does Knockout of Fibp in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Fibp
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Fibp (fibroblast growth factor (acidic) intracellular binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: fibroblast growth factor binding; CC: endomembrane system, membrane, nuclear speck, nucleus
Pathways:
UniProt: Q9JI19
Entrez ID: 58249
|
Does Knockout of Tmem62 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Tmem62
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tmem62 (transmembrane protein 62)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydrolase activity, molecular_function; CC: cellular_component, membrane
Pathways:
UniProt: Q8BXJ9
Entrez ID: 96957
|
Does Knockout of B3gnt9 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
B3gnt9
|
cell cycle progression
|
breast epithelium
|
Gene: B3gnt9 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: poly-N-acetyllactosamine biosynthetic process, protein O-linked glycosylation, protein glycosylation; MF: UDP-glycosyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Metabolism of proteins, O-linked glycosylation, O-linked glycosylation of mucins, Post-translational protein modification
UniProt: Q8VI16
Entrez ID: 97440
|
Does Knockout of Vmn1r57 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Vmn1r57
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vmn1r57 (vomeronasal 1 receptor 57)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: K7N731
Entrez ID: 665150
|
Does Knockout of H2-Eb2 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
H2-Eb2
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: H2-Eb2 (histocompatibility 2, class II antigen E beta2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, antigen processing and presentation, antigen processing and presentation of exogenous peptide antigen via MHC class II, antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, immune response, immune system process, peptide antigen assembly with MHC class II protein complex, positive regulation of T cell activation, positive regulation of immune response; MF: CD4 receptor binding, MHC class II protein complex binding, MHC class II receptor activity, T cell receptor binding, peptide antigen binding, polysaccharide binding; CC: MHC class II protein complex, cell surface, external side of plasma membrane, immunological synapse, late endosome membrane, lysosomal membrane, membrane, plasma membrane
Pathways: Adaptive Immune System, Allograft rejection - Mus musculus (mouse), Antigen processing and presentation - Mus musculus (mouse), Asthma - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Co-inhibition by PD-1, Downstream TCR signaling, Epstein-Barr virus infection - Mus musculus (mouse), Generation of second messenger molecules, Graft-versus-host disease - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Intestinal immune network for IgA production - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), MHC class II antigen presentation, Phagosome - Mus musculus (mouse), Phosphorylation of CD3 and TCR zeta chains, Regulation of T cell activation by CD28 family, Rheumatoid arthritis - Mus musculus (mouse), Staphylococcus aureus infection - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse), TCR signaling, Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Translocation of ZAP-70 to Immunological synapse, Tuberculosis - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse)
UniProt: Q3UUV9
Entrez ID: 381091
|
Does Knockout of Kti12 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Kti12
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Kti12 (KTI12 homolog, chromatin associated)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, molecular_function, nucleotide binding
Pathways:
UniProt: Q9D1R2
Entrez ID: 100087
|
Does Knockout of Mrpl42 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,268
|
Knockout
|
Mrpl42
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Mrpl42 (mitochondrial ribosomal protein L42)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial small ribosomal subunit, mitochondrion, plasma membrane, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CPV3
Entrez ID: 67270
|
Does Knockout of Slc22a22 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Slc22a22
|
cell proliferation
|
Regulatory T cell
|
Gene: Slc22a22 (solute carrier family 22 (organic cation transporter), member 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, monoatomic ion transport, organic anion transport, sodium-independent prostaglandin transport, transmembrane transport; MF: prostaglandin receptor activity, transmembrane transporter activity; CC: basolateral plasma membrane, membrane, plasma membrane
Pathways:
UniProt: Q8R0S9
Entrez ID: 210463
|
Does Knockout of A930011G23Rik in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
A930011G23Rik
|
phagocytosis
|
macrophage
|
Gene: A930011G23Rik (RIKEN cDNA A930011G23 gene)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 319818
|
Does Knockout of Fem1a in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Fem1a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Fem1a (fem 1 homolog a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, negative regulation of inflammatory response, positive regulation of inflammatory response, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination, regulation of ubiquitin-protein transferase activity, ubiquitin-dependent protein catabolic process via the C-end degron rule pathway; MF: EP4 subtype prostaglandin E2 receptor binding, molecular adaptor activity, ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, cytoplasm, mitochondrion, ubiquitin ligase complex
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9Z2G1
Entrez ID: 14154
|
Does Knockout of Vmn1r216 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Vmn1r216
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Vmn1r216 (vomeronasal 1 receptor 216)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8R257
Entrez ID: 171279
|
Does Knockout of Rps6ka4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Rps6ka4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rps6ka4 (ribosomal protein S6 kinase, polypeptide 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, chromatin remodeling, inflammatory response, interleukin-1-mediated signaling pathway, intracellular signal transduction, positive regulation of transcription by RNA polymerase II, post-translational protein modification, protein phosphorylation, regulation of DNA-templated transcription; MF: ATP binding, histone H3S10 kinase activity, histone H3S28 kinase activity, kinase activity, magnesium ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus, synapse
Pathways: MAPK signaling pathway - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse)
UniProt: Q9Z2B9
Entrez ID: 56613
|
Does Knockout of G2e3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
G2e3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: G2e3 (G2/M-phase specific E3 ubiquitin ligase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, blastocyst development, negative regulation of intrinsic apoptotic signaling pathway, protein polyubiquitination, protein ubiquitination; MF: metal ion binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: Golgi apparatus, cytoplasm, cytosol, nucleolus, nucleus
Pathways:
UniProt: Q5RJY2
Entrez ID: 217558
|
Does Knockout of Ndufb5 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Ndufb5
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ndufb5 (NADH:ubiquinone oxidoreductase subunit B5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrion, nucleoplasm, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CQH3
Entrez ID: 66046
|
Does Knockout of Cysrt1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Cysrt1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cysrt1 (cysteine rich tail 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological process involved in interaction with symbiont, biological_process, establishment of skin barrier; MF: identical protein binding, molecular_function; CC: cornified envelope
Pathways:
UniProt: Q9D1E4
Entrez ID: 67859
|
Does Knockout of Pld6 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Pld6
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pld6 (phospholipase D family member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: P granule organization, cell differentiation, lipid catabolic process, lipid metabolic process, meiotic cell cycle, mitochondrial fusion, phospholipid biosynthetic process, piRNA processing, positive regulation of mitochondrial fusion, spermatid development, spermatogenesis; MF: RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism, cardiolipin hydrolase activity, catalytic activity, endonuclease activity, hydrolase activity, identical protein binding, metal ion binding, nuclease activity, phospholipase D activity, protein binding, protein homodimerization activity, zinc ion binding; CC: Golgi apparatus, endoplasmic reticulum membrane, membrane, mitochondrial outer membrane, mitochondrion, nuclear membrane, nucleus, plasma membrane
Pathways: Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PA, choline biosynthesis III, phospholipases
UniProt: Q5SWZ9
Entrez ID: 194908
|
Does Knockout of Sucla2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Sucla2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Sucla2 (succinate-Coenzyme A ligase, ADP-forming, beta subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: succinate metabolic process, succinyl-CoA metabolic process, tricarboxylic acid cycle; MF: ATP binding, catalytic activity, ligase activity, magnesium ion binding, metal ion binding, nucleotide binding, succinate-CoA ligase (ADP-forming) activity, succinate-CoA ligase activity; CC: cytoplasm, mitochondrion, myelin sheath, succinate-CoA ligase complex, succinate-CoA ligase complex (ADP-forming)
Pathways: Aerobic respiration and respiratory electron transport, Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Metabolism, Propanoate metabolism - Mus musculus (mouse), glutamate degradation VII
UniProt: Q9Z2I9
Entrez ID: 20916
|
Does Knockout of Gtf2a1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Gtf2a1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gtf2a1 (general transcription factor II A, 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase II general transcription initiation factor binding, RNA polymerase II-specific DNA-binding transcription factor binding, TBP-class protein binding, protein binding, protein heterodimerization activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus, transcription factor TFIIA complex, transcription factor TFIID complex, transcription preinitiation complex
Pathways: Basal transcription factors - Mus musculus (mouse), ESR-mediated signaling, Estrogen-dependent gene expression, Gene expression (Transcription), RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Signal Transduction, Signaling by Nuclear Receptors, Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q99PM3
Entrez ID: 83602
|
Does Knockout of Vmn1r81 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Vmn1r81
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Vmn1r81 (vomeronasal 1 receptor 81)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8R286, A0A2I3BPG7
Entrez ID: 171244
|
Does Knockout of Stx19 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Stx19
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Stx19 (syntaxin 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exocytosis, intracellular protein transport, synaptic vesicle fusion to presynaptic active zone membrane, vesicle docking, vesicle-mediated transport; MF: SNAP receptor activity, SNARE binding; CC: SNARE complex, cytoplasm, endomembrane system, membrane, plasma membrane, presynaptic active zone membrane
Pathways: SNARE interactions in vesicular transport - Mus musculus (mouse)
UniProt: Q8R1Q0
Entrez ID: 68159
|
Does Knockout of Zfp30 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Zfp30
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Zfp30 (zinc finger protein 30)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q60585
Entrez ID: 22693
|
Does Knockout of Itgam in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Itgam
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Itgam (integrin alpha M)
Type: protein-coding
Summary: Enables complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development; complement-mediated synapse pruning; and endocytosis. Acts upstream of or within several processes, including activated T cell proliferation; microglia development; and neutrophil chemotaxis. Located in external side of plasma membrane and nucleus. Part of integrin alphaM-beta2 complex. Is expressed in several structures, including central nervous system; heart; hemolymphoid system; renal interstitium; and yolk sac. Human ortholog(s) of this gene implicated in lupus nephritis; persistent fetal circulation syndrome; and pre-eclampsia. Orthologous to human ITGAM (integrin subunit alpha M). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: activated T cell proliferation, amyloid-beta clearance, cell adhesion, cell-cell adhesion, cell-matrix adhesion, cellular extravasation, complement receptor mediated signaling pathway, complement-mediated synapse pruning, forebrain development, integrin-mediated signaling pathway, leukocyte adhesion to vascular endothelial cell, leukocyte cell-cell adhesion, leukocyte migration involved in inflammatory response, microglia development, microglial cell activation, negative regulation of dopamine metabolic process, neutrophil apoptotic process, neutrophil chemotaxis, phagocytosis, phagocytosis, engulfment, positive regulation of mast cell differentiation, positive regulation of microglial cell mediated cytotoxicity, positive regulation of neutrophil degranulation, positive regulation of protein targeting to membrane, positive regulation of superoxide anion generation, receptor-mediated endocytosis, vertebrate eye-specific patterning; MF: cargo receptor activity, complement component C3b binding, heat shock protein binding, heparan sulfate proteoglycan binding, heparin binding, metal ion binding, opsonin binding, protein binding, signaling receptor activity; CC: cell surface, external side of plasma membrane, extracellular space, integrin alphaM-beta2 complex, integrin complex, membrane, membrane raft, nucleus, plasma membrane, plasma membrane raft
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Complement and coagulation cascades - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Legionellosis - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Staphylococcus aureus infection - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: G5E8F1, E9Q604, E9Q5K8, A0A0R4J1B4, D6RJ73
Entrez ID: 16409
|
Does Knockout of Dnm2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Dnm2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Dnm2 (dynamin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor internalization, Golgi to plasma membrane transport, actin filament bundle organization, aorta development, autophagy, cellular response to dopamine, centrosome cycle, coronary vasculature development, endocytosis, macropinocytosis, membrane tubulation, negative regulation of membrane tubulation, negative regulation of non-motile cilium assembly, negative regulation of transforming growth factor beta receptor signaling pathway, neuron projection morphogenesis, phagocytosis, positive regulation of clathrin-dependent endocytosis, positive regulation of endocytosis, positive regulation of lamellipodium assembly, positive regulation of nitric oxide biosynthetic process, positive regulation of phagocytosis, positive regulation of substrate adhesion-dependent cell spreading, postsynaptic endocytosis, protein polymerization, receptor internalization, receptor-mediated endocytosis, regulation of Golgi organization, regulation of Rac protein signal transduction, regulation of axon extension, stress fiber assembly, synaptic vesicle budding from presynaptic endocytic zone membrane, synaptic vesicle endocytosis, transferrin transport, ventricular septum development, vesicle scission; MF: D2 dopamine receptor binding, GTP binding, GTPase activity, SH3 domain binding, WW domain binding, hydrolase activity, microtubule binding, nitric-oxide synthase binding, nucleotide binding, phosphatidylinositol 3-kinase regulatory subunit binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding, protein kinase binding, protein serine/threonine kinase binding, protein-containing complex binding; CC: Golgi apparatus, Golgi membrane, anchoring junction, cell junction, cell projection, centriole, centrosome, clathrin-coated endocytic vesicle, clathrin-coated pit, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, endosome, glutamatergic synapse, growth cone, lamellipodium, membrane, microtubule, midbody, neuron projection, perinuclear region of cytoplasm, phagocytic cup, phagocytic vesicle membrane, photoreceptor inner segment, plasma membrane, podosome, postsynaptic density, postsynaptic density, intracellular component, postsynaptic endocytic zone, postsynaptic membrane, presynapse, protein-containing complex, recycling endosome, ruffle membrane, synapse, trans-Golgi network, uropod
Pathways: Adaptive Immune System, Adherens junctions interactions, Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Clathrin-mediated endocytosis, Degradation of CDH1, Developmental Biology, Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Formation of annular gap junctions, Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, Golgi Associated Vesicle Biogenesis, Immune System, Innate Immune System, L1CAM interactions, Lysosome Vesicle Biogenesis, MHC class II antigen presentation, Membrane Trafficking, Metabolism, Metabolism of nitric oxide: NOS3 activation and regulation, NOSTRIN mediated eNOS trafficking, Nervous system development, Phospholipase D signaling pathway - Mus musculus (mouse), Recycling pathway of L1, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Salmonella infection - Mus musculus (mouse), Synaptic vesicle cycle - Mus musculus (mouse), Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades, Vesicle-mediated transport, cyclic AMP biosynthesis, trans-Golgi Network Vesicle Budding
UniProt: P39054
Entrez ID: 13430
|
Does Knockout of Ktn1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Ktn1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ktn1 (kinectin 1)
Type: protein-coding
Summary: Predicted to enable kinesin binding activity. Predicted to be involved in protein transport. Predicted to act upstream of or within microtubule-based movement. Located in endoplasmic reticulum. Is expressed in several structures, including genitourinary system; gut; heart; hemolymphoid system gland; and lung. Orthologous to human KTN1 (kinectin 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: microtubule-based movement, protein transport; MF: kinesin binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: CDC42 GTPase cycle, Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, RAC1 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases activate KTN1, RHOA GTPase cycle, RHOG GTPase cycle, RND2 GTPase cycle, RND3 GTPase cycle, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q61595
Entrez ID: 16709
|
Does Knockout of Vdr in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Vdr
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Vdr (vitamin D (1,25-dihydroxyvitamin D3) receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, apoptotic signaling pathway, calcium ion transport, cell differentiation, cell morphogenesis, cell-cell junction maintenance, decidualization, intestinal absorption, intracellular calcium ion homeostasis, intracellular receptor signaling pathway, lactation, mRNA transcription by RNA polymerase II, mammary gland branching involved in pregnancy, negative regulation of DNA-templated transcription, negative regulation of bone trabecula formation, negative regulation of cell population proliferation, negative regulation of keratinocyte proliferation, negative regulation of ossification, negative regulation of phosphate transmembrane transport, negative regulation of transcription by RNA polymerase II, nuclear receptor-mediated bile acid signaling pathway, nuclear receptor-mediated steroid hormone signaling pathway, phosphate ion transmembrane transport, positive regulation of apoptotic process involved in mammary gland involution, positive regulation of bone mineralization, positive regulation of gene expression, positive regulation of keratinocyte differentiation, positive regulation of parathyroid hormone secretion, positive regulation of transcription by RNA polymerase II, positive regulation of vitamin D receptor signaling pathway, regulation of DNA-templated transcription, regulation of calcium ion transport, response to bile acid, retinoic acid receptor signaling pathway, skeletal system development, vitamin D receptor signaling pathway; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, bile acid nuclear receptor activity, calcitriol binding, lithocholic acid binding, metal ion binding, nuclear receptor activity, nuclear retinoid X receptor binding, nuclear steroid receptor activity, protein binding, sequence-specific DNA binding, vitamin D binding, vitamin D response element binding, zinc ion binding; CC: RNA polymerase II transcription regulator complex, T-tubule, caveola, chromatin, cytoplasm, cytosol, dense fibrillar component, euchromatin, heterochromatin, nuclear matrix, nucleoplasm, nucleus, perinuclear region of cytoplasm, receptor complex
Pathways: Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroids, Mineral absorption - Mus musculus (mouse), Nuclear Receptor transcription pathway, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Post-translational protein modification, RNA Polymerase II Transcription, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of intracellular receptors, Tuberculosis - Mus musculus (mouse), Vitamin D (calciferol) metabolism
UniProt: P48281
Entrez ID: 22337
|
Does Knockout of Crisp3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Crisp3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Crisp3 (cysteine-rich secretory protein 3)
Type: protein-coding
Summary: Predicted to be involved in sexual reproduction. Predicted to be located in extracellular region and transport vesicle. Predicted to be active in extracellular space. Is expressed in sublingual gland and submandibular gland. [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: CC: cytoplasmic vesicle, extracellular region, extracellular space, transport vesicle
Pathways:
UniProt: Q03402
Entrez ID: 11572
|
Does Knockout of L1cam in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
L1cam
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: L1cam (L1 cell adhesion molecule)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon development, axon guidance, axonal fasciculation, cell adhesion, cell differentiation, cell migration, cell surface receptor signaling pathway, cell-cell adhesion mediated by integrin, cell-matrix adhesion, cerebellar neuron development, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, homophilic cell adhesion via plasma membrane adhesion molecules, homotypic cell-cell adhesion, leukocyte cell-cell adhesion, maintenance of synapse structure, modulation of chemical synaptic transmission, nervous system development, neuron projection development, positive regulation of axon extension, positive regulation of calcium-mediated signaling, positive regulation of cell adhesion, positive regulation of cell-cell adhesion, positive regulation of cell-substrate adhesion, protein localization to plasma membrane raft, regulation of ERK1 and ERK2 cascade, regulation of neuron projection development, regulation of synapse assembly, response to toluene, synapse organization; MF: PDZ domain binding, axon guidance receptor activity, identical protein binding, integrin binding, protein binding, protein domain specific binding, sialic acid binding; CC: GABA-ergic synapse, Schaffer collateral - CA1 synapse, axon, axonal growth cone, cell projection, cell surface, dendrite, dendritic growth cone, endosome, external side of plasma membrane, glutamatergic synapse, growth cone, membrane, neuronal cell body, plasma membrane, presynaptic membrane, terminal bouton
Pathways: Axon guidance - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse)
UniProt: A2AFG8, Q6PGJ3, A2AFG7, B7ZCD3, F6UIL7, F7A5H7
Entrez ID: 16728
|
Does Knockout of Snx12 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Snx12
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Snx12 (sorting nexin 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endocytic recycling, late endosome to Golgi transport, negative regulation of early endosome to late endosome transport, negative regulation of gene expression, negative regulation of protein catabolic process, negative regulation of protein processing, negative regulation of protein transport, protein transport, regulation of endocytosis, regulation of protein metabolic process, regulation of protein transport; MF: enzyme binding, lipid binding, phosphatidylinositol binding, phosphatidylinositol-3-phosphate binding; CC: early endosome, early endosome membrane, membrane, retromer complex
Pathways: Endocytosis - Mus musculus (mouse)
UniProt: O70493
Entrez ID: 55988
|
Does Knockout of Nudt4 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Nudt4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Nudt4 (nudix hydrolase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adenosine 5'-(hexahydrogen pentaphosphate) catabolic process, diadenosine hexaphosphate catabolic process, diadenosine pentaphosphate catabolic process, diphosphoinositol polyphosphate metabolic process; MF: 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity, RNA binding, bis(5'-adenosyl)-hexaphosphatase activity, bis(5'-adenosyl)-pentaphosphatase activity, diphosphoinositol-polyphosphate diphosphatase activity, endopolyphosphatase activity, hydrolase activity, inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity, inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity, inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity, metal ion binding, pyrophosphatase activity, snoRNA binding; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q8R2U6
Entrez ID: 71207
|
Does Knockout of Vmn1r203 in Cytotoxic T-lymphocyte (CD8+ T cells) causally result in cell proliferation?
| 1
| 2,411
|
Knockout
|
Vmn1r203
|
cell proliferation
|
Cytotoxic T-lymphocyte (CD8+ T cells)
|
Gene: Vmn1r203 (vomeronasal 1 receptor 203)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8R273
Entrez ID: 171270
|
Does Knockout of Ephx1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Ephx1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ephx1 (epoxide hydrolase 1, microsomal)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate metabolic process, cellular response to glucocorticoid stimulus, diol biosynthetic process, epoxide metabolic process, hydrocarbon catabolic process, lipid metabolic process, liver development, response to toxic substance; MF: catalytic activity, cis-stilbene-oxide hydrolase activity, enzyme binding, epoxide hydrolase activity, ether hydrolase activity, hydrolase activity, oxysterol binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Bile secretion - Mus musculus (mouse), Biological oxidations, Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Metabolism, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Phase I - Functionalization of compounds
UniProt: Q9D379
Entrez ID: 13849
|
Does Knockout of Klk10 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,179
|
Knockout
|
Klk10
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Klk10 (kallikrein related-peptidase 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein maturation, proteolysis; MF: protein binding, serine-type endopeptidase activity; CC: extracellular space, secretory granule
Pathways:
UniProt: Q99M20
Entrez ID: 69540
|
Does Knockout of Mslnl in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Mslnl
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mslnl (mesothelin-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-matrix adhesion; CC: cell surface, membrane
Pathways:
UniProt: Q8C160
Entrez ID: 328783
|
Does Knockout of Snx7 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Snx7
|
cell proliferation
|
Regulatory T cell
|
Gene: Snx7 (sorting nexin 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endocytic recycling, mitophagy, piecemeal microautophagy of the nucleus, positive regulation of autophagosome assembly, protein transport, reticulophagy; MF: lipid binding, phosphatidylinositol binding, protein binding; CC: cytoplasm, early endosome, early endosome membrane, endosome, membrane, phagophore assembly site
Pathways:
UniProt: Q9CY18
Entrez ID: 76561
|
Does Knockout of Btbd18 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Btbd18
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Btbd18 (BTB domain containing 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, male meiosis I, piRNA transcription, positive regulation of transcription elongation by RNA polymerase II, spermatogenesis, transposable element silencing; CC: nucleus
Pathways:
UniProt: A0A0A6YY25
Entrez ID: 100270744
|
Does Knockout of Pum2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Pum2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pum2 (pumilio RNA-binding family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adipose tissue development, chromosome organization, hair follicle development, miRNA processing, mitochondrion organization, negative regulation of gene expression, positive regulation of RIG-I signaling pathway, positive regulation of miRNA-mediated gene silencing, positive regulation of sprouting of injured axon, post-transcriptional regulation of gene expression, regulation of chromosome segregation, regulation of intracellular mRNA localization, regulation of mRNA stability, regulation of postsynapse assembly, regulation of translation, respiratory electron transport chain, skeletal system development, stress granule assembly; MF: RNA binding, lncRNA binding, mRNA 3'-UTR binding, miRNA binding, protein binding, pumilio-response element binding; CC: cytoplasm, cytoplasmic stress granule, cytosol, glutamatergic synapse, neuronal cell body, nuclear membrane, perinuclear region of cytoplasm, postsynapse
Pathways: Spinocerebellar ataxia - Mus musculus (mouse)
UniProt: Q80U58
Entrez ID: 80913
|
Does Knockout of Ccdc90b in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Ccdc90b
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ccdc90b (coiled-coil domain containing 90B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, mitochondrial membrane, mitochondrion
Pathways:
UniProt: Q8C3X2
Entrez ID: 66365
|
Does Knockout of Slc27a4 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Slc27a4
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Slc27a4 (solute carrier family 27 (fatty acid transporter), member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment of localization in cell, fatty acid metabolic process, fatty acid transport, glucose import in response to insulin stimulus, lipid metabolic process, lipid transport, lipid transport across blood-brain barrier, long-chain fatty acid import into cell, long-chain fatty acid metabolic process, long-chain fatty acid transport, medium-chain fatty acid transport, negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity, negative regulation of insulin receptor signaling pathway, positive regulation of apoptotic process, response to nutrient, skin development, very long-chain fatty acid catabolic process, very long-chain fatty acid metabolic process; MF: arachidonate-CoA ligase activity, ligase activity, long-chain fatty acid transmembrane transporter activity, long-chain fatty acid-CoA ligase activity, nucleotide binding, oleoyl-CoA ligase activity, palmitoyl-CoA ligase activity, very long-chain fatty acid-CoA ligase activity; CC: brush border membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, microvillus, plasma membrane
Pathways: Fat digestion and absorption - Mus musculus (mouse), Insulin resistance - Mus musculus (mouse), PPAR signaling pathway - Mus musculus (mouse), SLC-mediated transmembrane transport, Transport of fatty acids, Transport of small molecules, Transport of vitamins, nucleosides, and related molecules
UniProt: Q91VE0
Entrez ID: 26569
|
Does Knockout of Gm10322 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Gm10322
|
phagocytosis
|
macrophage
|
Gene: Gm10322 (predicted gene 10322)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Cracr2b in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,663
|
Knockout
|
Cracr2b
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cracr2b (calcium release activated channel regulator 2B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, store-operated calcium entry; MF: calcium ion binding, molecular_function, ubiquitin-protein transferase activity
Pathways:
UniProt: Q80ZJ8
Entrez ID: 213573
|
Does Knockout of Itln1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Itln1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Itln1 (intelectin 1 (galactofuranose binding))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of D-glucose import, positive regulation of protein phosphorylation, response to nematode; MF: calcium ion binding, carbohydrate binding, identical protein binding, metal ion binding, oligosaccharide binding; CC: brush border membrane, extracellular matrix, extracellular region, extracellular space, membrane, membrane raft, plasma membrane, receptor complex, side of membrane
Pathways: Antimicrobial peptides, Immune System, Innate Immune System
UniProt: O88310
Entrez ID: 16429
|
Does Knockout of Cyp2c55 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Cyp2c55
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cyp2c55 (cytochrome P450, family 2, subfamily c, polypeptide 55)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate metabolic process, epoxygenase P450 pathway, linoleic acid metabolic process, retinoic acid metabolic process, xenobiotic catabolic process; MF: arachidonate epoxygenase activity, arachidonate monooxygenase activity, heme binding, iron ion binding, linoleic acid epoxygenase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, retinoic acid 4-hydroxylase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, plasma membrane
Pathways: Arachidonic acid metabolism - Mus musculus (mouse), Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Linoleic acid metabolism - Mus musculus (mouse), Retinol metabolism - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse), bupropion degradation, nicotine degradation II, nicotine degradation III
UniProt: Q9D816
Entrez ID: 72082
|
Does Knockout of Slc30a5 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Slc30a5
|
cell cycle progression
|
breast epithelium
|
Gene: Slc30a5 (solute carrier family 30 (zinc transporter), member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GPI anchor biosynthetic process, cobalt ion transport, insulin processing, intracellular zinc ion homeostasis, monoatomic cation transport, monoatomic ion transport, response to zinc ion, transmembrane transport, zinc ion import across plasma membrane, zinc ion import into Golgi lumen, zinc ion import into organelle, zinc ion transport; MF: antiporter activity, metal ion binding, monoatomic cation transmembrane transporter activity, zinc efflux transmembrane transporter activity, zinc ion transmembrane transporter activity, zinc:proton antiporter activity; CC: ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi cis cisterna membrane, Golgi cisterna membrane, Golgi membrane, apical plasma membrane, cytoplasmic vesicle, endoplasmic reticulum membrane, membrane, nucleolus, nucleoplasm, plasma membrane, secretory granule, secretory granule membrane, trans-Golgi network membrane, transport vesicle membrane
Pathways: Insulin processing, Metabolism of proteins, Metal ion SLC transporters, Peptide hormone metabolism, SLC-mediated transmembrane transport, Transport of small molecules, Zinc efflux and compartmentalization by the SLC30 family, Zinc transporters
UniProt: Q8R4H9
Entrez ID: 69048
|
Does Knockout of Cdk19 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Cdk19
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cdk19 (cyclin dependent kinase 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to lipopolysaccharide, positive regulation of apoptotic process, regulation of cell cycle; MF: ATP binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: Q8BWD8
Entrez ID: 78334
|
Does Knockout of Mark4 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Mark4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Mark4 (MAP/microtubule affinity regulating kinase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, cell projection organization, cilium disassembly, cilium organization, intracellular signal transduction, microtubule bundle formation, microtubule cytoskeleton organization, microtubule polymerization, nervous system development, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of cell cycle, positive regulation of cilium assembly, positive regulation of protein localization to centrosome, protein phosphorylation, regulation of centrosome cycle; MF: ATP binding, cytoskeletal anchor activity, gamma-tubulin binding, kinase activity, microtubule binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, tau-protein kinase activity, transferase activity; CC: cell projection, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, dendrite, gamma-tubulin complex, microtubule cytoskeleton, microtubule organizing center, midbody, neuron projection
Pathways: Anchoring of the basal body to the plasma membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: Q8CIP4
Entrez ID: 232944
|
Does Knockout of Dlx4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Dlx4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dlx4 (distal-less homeobox 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, embryonic skeletal system development, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: P70436
Entrez ID: 13394
|
Does Knockout of Ccnc in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Ccnc
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ccnc (cyclin C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G0 to G1 transition, negative regulation of Notch signaling pathway, negative regulation of triglyceride metabolic process, positive regulation of transcription by RNA polymerase II, protein ubiquitination, regulation of transcription by RNA polymerase II; MF: cyclin-dependent protein serine/threonine kinase regulator activity, identical protein binding, ubiquitin protein ligase activity; CC: CKM complex, cyclin-dependent protein kinase holoenzyme complex, mediator complex, nucleoplasm, nucleus, protein-containing complex, ubiquitin ligase complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
UniProt: Q62447
Entrez ID: 51813
|
Does Knockout of Pygb in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Pygb
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pygb (brain glycogen phosphorylase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, glycogen catabolic process, glycogen metabolic process; MF: 1,4-alpha-oligoglucan phosphorylase activity, carbohydrate binding, catalytic activity, glycogen phosphorylase activity, glycosyltransferase activity, identical protein binding, pyridoxal phosphate binding, transferase activity; CC: axon, cytoplasm
Pathways: Glucagon signaling pathway - Mus musculus (mouse), Immune System, Innate Immune System, Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Neutrophil degranulation, Starch and sucrose metabolism - Mus musculus (mouse), glycogen degradation II, glycogen degradation III, starch degradation
UniProt: Q8CI94
Entrez ID: 110078
|
Does Knockout of Col11a1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Col11a1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Col11a1 (collagen, type XI, alpha 1)
Type: protein-coding
Summary: This gene encodes the alpha-1 subunit of type XI collagen, one of the low abundance fibrillar collagens that is essential for normal embryonic skeletal development and the cohesive properties of cartilage. The encoded protein, in association with the alpha-1 subunit of type II collagen, forms a heterotrimeric type XI procollagen that undergoes proteolytic processing. Mice lacking the encoded protein develop severe chondrodysplasia and die at birth. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: cartilage condensation, cartilage development, chondrocyte development, collagen fibril organization, detection of mechanical stimulus involved in sensory perception of sound, embryonic skeletal system morphogenesis, endodermal cell differentiation, heart morphogenesis, inner ear morphogenesis, proteoglycan metabolic process, sensory perception of sound, skeletal system morphogenesis, tendon development, ventricular cardiac muscle tissue morphogenesis, visual perception; MF: extracellular matrix structural constituent, extracellular matrix structural constituent conferring tensile strength, heparan sulfate binding, heparin binding, metal ion binding; CC: collagen trimer, collagen type II trimer, collagen type XI trimer, extracellular matrix, extracellular region, extracellular space
Pathways: Assembly of collagen fibrils and other multimeric structures, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen degradation, Collagen formation, Degradation of the extracellular matrix, Extracellular matrix organization, MET activates PTK2 signaling, MET promotes cell motility, Non-integrin membrane-ECM interactions, Protein digestion and absorption - Mus musculus (mouse), Signal Transduction, Signaling by MET, Signaling by Receptor Tyrosine Kinases
UniProt: Q61245
Entrez ID: 12814
|
Does Knockout of Mcrs1 in Pancreatic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,195
|
Knockout
|
Mcrs1
|
protein/peptide accumulation
|
Pancreatic Cell Line
|
Gene: Mcrs1 (microspherule protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, chromatin organization, chromatin remodeling, negative regulation of telomere maintenance via telomere lengthening, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of macromolecule metabolic process, positive regulation of nucleobase-containing compound metabolic process, positive regulation of protein localization to nucleolus, positive regulation of telomere maintenance in response to DNA damage, positive regulation of transcription by RNA polymerase II, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of cell cycle, regulation of chromosome organization, regulation of embryonic development, regulation of telomere maintenance, telomere maintenance; MF: G-quadruplex RNA binding, poly(G) binding, poly(U) RNA binding, telomerase inhibitor activity; CC: Ino80 complex, MLL1 complex, NSL complex, centriolar satellite, centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, dendrite, histone acetyltransferase complex, kinetochore, lysosome, nuclear body, nucleolus, nucleoplasm, nucleus, perikaryon, spindle pole
Pathways: Chromatin modifying enzymes, Chromatin organization, DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), Global Genome Nucleotide Excision Repair (GG-NER), HATs acetylate histones, Metabolism of proteins, Nucleotide Excision Repair, Post-translational protein modification, UCH proteinases
UniProt: Q99L90
Entrez ID: 51812
|
Does Knockout of Foxp2 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Foxp2
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Foxp2 (forkhead box P2)
Type: protein-coding
Summary: Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and transcription coregulator binding activity. Involved in cerebellar Purkinje cell differentiation; gene expression; and vocalization behavior. Acts upstream of or within several processes, including positive regulation of cell population proliferation; righting reflex; and vocal learning. Is active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculoskeletal system; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autism spectrum disorder (multiple); communication disorder (multiple); dyslexia; and major depressive disorder. Orthologous to human FOXP2 (forkhead box P2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: camera-type eye development, caudate nucleus development, cerebellar Purkinje cell differentiation, cerebellum development, cerebral cortex development, gene expression, innate vocalization behavior, lung alveolus development, lung development, lung epithelium development, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of epithelial cell proliferation, positive regulation of epithelial cell proliferation involved in lung morphogenesis, positive regulation of mesenchymal cell proliferation, post-embryonic development, putamen development, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, righting reflex, skeletal muscle tissue development, smooth muscle tissue development, vocal learning, vocalization behavior; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding, nuclear androgen receptor binding, protein binding, protein homodimerization activity, sequence-specific DNA binding, transcription coregulator binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: P58463
Entrez ID: 114142
|
Does Knockout of Rbm12 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Rbm12
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rbm12 (RNA binding motif protein 12)
Type: protein-coding
Summary: This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for copine I overlap at map location 2 H2. Two alternatively spliced transcript variants have been identified for this gene. Both variants encode the same protein. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: RNA binding, nucleic acid binding; CC: nucleoplasm, nucleus, ribonucleoprotein complex
Pathways:
UniProt: Q8R4X3
Entrez ID: 75710
|
Does Knockout of Polr2j in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Polr2j
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Polr2j (polymerase (RNA) II (DNA directed) polypeptide J)
Type: protein-coding
Summary: Predicted to enable LRR domain binding activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II, core complex. Is expressed in several structures, including alimentary system; branchial arch; integumental system; limb; and nervous system. Orthologous to several human genes including POLR2J (RNA polymerase II subunit J). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA-templated transcription, transcription by RNA polymerase II; MF: DNA binding, DNA-directed RNA polymerase activity, LRR domain binding, protein binding, protein dimerization activity; CC: DNA-directed RNA polymerase complex, RNA polymerase II, core complex, nucleoplasm, nucleus
Pathways: Huntington disease - Mus musculus (mouse), RNA polymerase - Mus musculus (mouse)
UniProt: Q3TYI2, Q6PI63, D3YZ19, D3YZ20
Entrez ID: 20022
|
Does Knockout of Mfsd6l in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Mfsd6l
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Mfsd6l (major facilitator superfamily domain containing 6-like)
Type: protein-coding
Summary: Predicted to be active in membrane. Orthologous to human MFSD6L (major facilitator superfamily domain containing 6 like). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: membrane
Pathways:
UniProt: Q8R3N2
Entrez ID: 215723
|
Does Knockout of Ascl1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Ascl1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Ascl1 (achaete-scute family bHLH transcription factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GABAergic neuron differentiation, Notch signaling pathway, adrenal chromaffin cell differentiation, carotid body glomus cell differentiation, cell differentiation, cell maturation, cellular response to magnetism, central nervous system neuron development, cerebral cortex GABAergic interneuron differentiation, cerebral cortex development, commitment of neuronal cell to specific neuron type in forebrain, enteric nervous system development, forebrain neuron differentiation, generation of neurons, heart development, lung neuroendocrine cell differentiation, motor neuron migration, musculoskeletal movement, spinal reflex action, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of neuron differentiation, negative regulation of transcription by RNA polymerase II, nervous system development, neuroblast fate determination, neuroblast proliferation, neuroendocrine cell differentiation, neurogenesis, neuron development, neuron differentiation, neuron fate commitment, neuron fate specification, noradrenergic neuron development, noradrenergic neuron fate commitment, olfactory pit development, oligodendrocyte cell fate commitment, oligodendrocyte development, oligodendrocyte differentiation, parasympathetic nervous system development, pattern specification process, peripheral nervous system neuron development, positive regulation of Notch signaling pathway, positive regulation of cell cycle, positive regulation of neural precursor cell proliferation, positive regulation of neurogenesis, positive regulation of neuron apoptotic process, positive regulation of neuron differentiation, positive regulation of transcription by RNA polymerase II, regulation of Notch signaling pathway, regulation of cell differentiation, regulation of cell population proliferation, regulation of epithelial cell differentiation, regulation of gene expression, regulation of mitotic cell cycle, regulation of neurogenesis, regulation of timing of subpallium neuron differentiation, regulation of transcription by RNA polymerase II, response to epidermal growth factor, response to folic acid, response to retinoic acid, sensory organ development, spinal cord association neuron differentiation, spinal cord oligodendrocyte cell differentiation, spinal cord oligodendrocyte cell fate specification, stomach neuroendocrine cell differentiation, subpallium neuron fate commitment, sympathetic ganglion development, sympathetic nervous system development, ventral spinal cord interneuron fate commitment, vestibular nucleus development; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, bHLH transcription factor binding, chromatin binding, double-stranded DNA binding, identical protein binding, nucleic acid binding, protein binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription regulator complex, neuronal cell body, nucleus
Pathways:
UniProt: Q02067
Entrez ID: 17172
|
Does Knockout of Cracr2a in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Cracr2a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cracr2a (calcium release activated channel regulator 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T-helper 1 cell differentiation, activation of store-operated calcium channel activity, adaptive immune response, calcium ion transport, endosomal transport, immune system process, intracellular protein localization, monoatomic ion transport, positive regulation of JNK cascade, positive regulation of calcium ion transport, response to histamine, store-operated calcium entry, vesicle-mediated transport; MF: G protein activity, GTP binding, GTPase activity, calcium ion binding, hydrolase activity, metal ion binding, nucleotide binding; CC: Golgi apparatus, Golgi membrane, Weibel-Palade body, cytoplasm, cytoskeleton, immunological synapse, membrane, microtubule organizing center, plasma membrane, trans-Golgi network membrane, vesicle
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q3UP38
Entrez ID: 381812
|
Does Knockout of Wwp1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Wwp1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Wwp1 (WW domain containing E3 ubiquitin protein ligase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell differentiation, lung development, negative regulation of DNA-templated transcription, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity; CC: anchoring junction, cytoplasm, cytosol, membrane, nucleus, plasma membrane
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Downregulation of ERBB4 signaling, Endocytosis - Mus musculus (mouse), Immune System, Ion channel transport, Signal Transduction, Signaling by ERBB4, Signaling by Receptor Tyrosine Kinases, Stimuli-sensing channels, Transport of small molecules, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q8BZZ3
Entrez ID: 107568
|
Does Knockout of Impa2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Impa2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Impa2 (inositol monophosphatase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: inositol biosynthetic process, inositol metabolic process, phosphatidylinositol phosphate biosynthetic process, response to lithium ion, signal transduction; MF: glucose-1-phosphatase activity, glycerol-2-phosphatase activity, hydrolase activity, inositol monophosphate 1-phosphatase activity, inositol monophosphate 3-phosphatase activity, inositol monophosphate 4-phosphatase activity, inositol monophosphate phosphatase activity, metal ion binding, protein homodimerization activity; CC: cytoplasm
Pathways: <i>myo</i>-inositol biosynthesis, Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Synthesis of IP2, IP, and Ins in the cytosol
UniProt: Q91UZ5
Entrez ID: 114663
|
Does Knockout of Phc2 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Phc2
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Phc2 (polyhomeotic 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, spermatogenesis; MF: DNA binding, chromatin binding, histone binding, identical protein binding, metal ion binding, protein binding, zinc ion binding; CC: PRC1 complex, PcG protein complex, heterochromatin, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of RNA binding proteins, SUMOylation of chromatin organization proteins, SUMOylation of transcription cofactors, Transcriptional regulation by RUNX1
UniProt: Q9QWH1
Entrez ID: 54383
|
Does Knockout of Gnl3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Gnl3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gnl3 (guanine nucleotide binding protein nucleolar 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of miRNA transcription, positive regulation of protein localization to chromosome, telomeric region, positive regulation of protein sumoylation, positive regulation of telomere maintenance, regulation of cell population proliferation, stem cell division, stem cell population maintenance; MF: GTP binding, mRNA 5'-UTR binding, nucleotide binding, protein binding; CC: chromosome, midbody, nuclear body, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8CI11
Entrez ID: 30877
|
Does Knockout of Nat2 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Nat2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Nat2 (N-acetyltransferase 2 (arylamine N-acetyltransferase))
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: N-acetyltransferase activity, N-hydroxyarylamine O-acetyltransferase activity, acetyltransferase activity, acyltransferase activity, arylamine N-acetyltransferase activity, transferase activity
Pathways: Acetylation, Biological oxidations, Caffeine metabolism - Mus musculus (mouse), Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Drug ADME, Drug metabolism - other enzymes - Mus musculus (mouse), Metabolism, Paracetamol ADME, Phase II - Conjugation of compounds
UniProt: P50295
Entrez ID: 17961
|
Does Knockout of Prkaa1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Prkaa1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Prkaa1 (protein kinase, AMP-activated, alpha 1 catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CAMKK-AMPK signaling cascade, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, TORC1 signaling, Wnt signaling pathway, autophagosome assembly, autophagy, cellular response to amino acid starvation, cellular response to calcium ion, cellular response to ethanol, cellular response to glucose starvation, cellular response to glucose stimulus, cellular response to hydrogen peroxide, cellular response to hypoxia, cellular response to nutrient levels, cellular response to oxidative stress, cellular response to prostaglandin E stimulus, cellular response to starvation, cellular response to stress, cellular response to xenobiotic stimulus, cholesterol biosynthetic process, cholesterol metabolic process, chromatin organization, chromatin remodeling, circadian regulation of gene expression, cold acclimation, cytoplasmic translation, energy homeostasis, fatty acid biosynthetic process, fatty acid homeostasis, fatty acid metabolic process, fatty acid oxidation, glucose homeostasis, glucose metabolic process, hepatocyte apoptotic process, lipid biosynthetic process, lipid droplet disassembly, lipid metabolic process, lysosome organization, motor behavior, negative regulation of T cell activation, negative regulation of T cell mediated immune response to tumor cell, negative regulation of TOR signaling, negative regulation of TORC1 signaling, negative regulation of apoptotic process, negative regulation of gene expression, negative regulation of hepatocyte apoptotic process, negative regulation of insulin receptor signaling pathway, negative regulation of lipid catabolic process, negative regulation of protein localization to nucleus, negative regulation of translational initiation, negative regulation of tubulin deacetylation, neuron cellular homeostasis, phosphatidylcholine biosynthetic process, phosphatidylethanolamine biosynthetic process, positive regulation of DNA-templated transcription, positive regulation of T cell activation, positive regulation of T cell mediated immune response to tumor cell, positive regulation of TORC1 signaling, positive regulation of adipose tissue development, positive regulation of autophagy, positive regulation of catabolic process, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of glycolytic process, positive regulation of mitochondrial transcription, positive regulation of protein localization, positive regulation of protein targeting to mitochondrion, positive regulation of release of cytochrome c from mitochondria, positive regulation of skeletal muscle tissue development, positive regulation of translational initiation, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K6-linked ubiquitination, protein destabilization, protein localization to lipid droplet, protein localization to lysosome, protein localization to membrane, protein localization to plasma membrane, protein stabilization, protein-containing complex assembly, regulation of circadian rhythm, regulation of microtubule cytoskeleton organization, regulation of stress granule assembly, regulation of vascular permeability, regulation of vesicle-mediated transport, response to UV, response to activity, response to caffeine, response to estrogen, response to gamma radiation, response to hydrogen peroxide, response to xenobiotic stimulus, rhythmic process, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process; MF: AMP-activated protein kinase activity, ATP binding, [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity, chromatin binding, histone H2BS36 kinase activity, kinase activity, kinase binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, transferase activity; CC: apical plasma membrane, axon, chromatin, ciliary basal body, cilium, cytoplasm, cytosol, dendrite, neuronal cell body, nuclear speck, nucleotide-activated protein kinase complex, nucleus, protein-containing complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), Adaptive Immune System, Adipocytokine signaling pathway - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Autophagy, Autophagy - animal - Mus musculus (mouse), Circadian rhythm - Mus musculus (mouse), Co-inhibition by PD-1, Energy dependent regulation of mTOR by LKB1-AMPK, Fluid shear stress and atherosclerosis - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Glucagon signaling pathway - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Immune System, Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MTOR signalling, Macroautophagy, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Signal Transduction, TP53 Regulates Metabolic Genes, Thermogenesis - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Transcriptional Regulation by TP53, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q5EG47
Entrez ID: 105787
|
Does Knockout of Snapc4 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Snapc4
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Snapc4 (small nuclear RNA activating complex, polypeptide 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: snRNA transcription by RNA polymerase II, snRNA transcription by RNA polymerase III; MF: DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase III general transcription initiation factor activity, RNA polymerase III type 3 promoter sequence-specific DNA binding; CC: nucleus, snRNA-activating protein complex
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase II transcribes snRNA genes
UniProt: Q8BP86
Entrez ID: 227644
|
Does Knockout of Osbpl8 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Osbpl8
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Osbpl8 (oxysterol binding protein-like 8)
Type: protein-coding
Summary: This gene encodes a member of the oxysterol-binding protein (Osbp) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal Osbp-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: fat cell differentiation, intermembrane lipid transfer, lipid transport, negative regulation of cell migration, phospholipid transport, positive regulation of D-glucose import, positive regulation of insulin receptor signaling pathway, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, protein localization to nuclear pore, triglyceride homeostasis; MF: cholesterol binding, lipid binding, phosphatidylinositol-4-phosphate binding, phosphatidylserine binding, phosphatidylserine transfer activity, protein binding; CC: cortical endoplasmic reticulum, cytosol, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear membrane, nucleus
Pathways: Acyl chain remodelling of PS, Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism
UniProt: B9EJ86
Entrez ID: 237542
|
Does Knockout of Peak1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,683
|
Knockout
|
Peak1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Peak1 (pseudopodium-enriched atypical kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, focal adhesion assembly, regulation of cell motility, regulation of focal adhesion assembly, substrate adhesion-dependent cell spreading; MF: ATP binding, identical protein binding, non-membrane spanning protein tyrosine kinase activity, protein kinase activity; CC: actin cytoskeleton, anchoring junction, cytoplasm, cytoskeleton, cytosol, focal adhesion
Pathways: RHO GTPase cycle, RHOU GTPase cycle, RHOV GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q69Z38
Entrez ID: 244895
|
Does Knockout of Wdr5 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Wdr5
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Wdr5 (WD repeat domain 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, negative regulation of transcription by RNA polymerase II, neuron projection development, positive regulation of DNA-templated transcription, positive regulation of gluconeogenesis, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell division, regulation of embryonic development, regulation of transcription by RNA polymerase II, skeletal system development, transcription initiation-coupled chromatin remodeling; MF: histone H3K4 methyltransferase activity, histone H3K4me1 reader activity, histone H3Q5ser reader activity, histone binding, protein binding; CC: ATAC complex, MLL1 complex, MLL1/2 complex, MLL3/4 complex, NSL complex, Set1C/COMPASS complex, histone acetyltransferase complex, histone methyltransferase complex, mitotic spindle, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Cushing syndrome - Mus musculus (mouse), Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), Generic Transcription Pathway, HATs acetylate histones, Metabolism of proteins, Neddylation, PKMTs methylate histone lysines, Post-translational protein modification, RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Transcriptional regulation by RUNX1
UniProt: P61965
Entrez ID: 140858
|
Does Knockout of Tssc4 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Tssc4
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Tssc4 (tumor-suppressing subchromosomal transferable fragment 4)
Type: protein-coding
Summary: Predicted to enable molecular sequestering activity. Predicted to be involved in spliceosomal tri-snRNP complex assembly. Predicted to be part of U5 snRNP. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including extraembryonic component; gut; liver; placenta; and spleen. Orthologous to human TSSC4 (tumor suppressing subtransferable candidate 4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, biological_process, mRNA processing, spliceosomal snRNP assembly, spliceosomal tri-snRNP complex assembly; MF: molecular sequestering activity, molecular_function, protein-containing complex binding; CC: U5 snRNP, cellular_component, cytoplasm, nucleus, spliceosomal complex
Pathways:
UniProt: Q9JHE7
Entrez ID: 56844
|
Does Knockout of Rhof in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Rhof
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rhof (ras homolog family member F (in filopodia))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, cell migration, regulation of actin cytoskeleton organization, signal transduction, small GTPase-mediated signal transduction; MF: GTP binding, GTPase activity, nucleotide binding, protein kinase binding; CC: cytoplasm, cytoskeleton, cytosol, membrane, plasma membrane
Pathways: Immune System, Innate Immune System, Neutrophil degranulation, RHO GTPase cycle, RHOF GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8BYP3
Entrez ID: 23912
|
Does Knockout of Bet1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Bet1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Bet1 (Bet1 golgi vesicular membrane trafficking protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, protein transport, vesicle fusion with Golgi apparatus, vesicle-mediated transport; MF: SNAP receptor activity, syntaxin binding; CC: Golgi apparatus, Golgi cis cisterna, Golgi cisterna, Golgi membrane, SNARE complex, cis-Golgi network, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, SNARE interactions in vesicular transport - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: O35623
Entrez ID: 12068
|
Does Knockout of Prkdc in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Prkdc
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Prkdc (protein kinase, DNA activated, catalytic polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell lineage commitment, DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, T cell differentiation in thymus, T cell lineage commitment, T cell receptor V(D)J recombination, V(D)J recombination, activation of innate immune response, brain development, cGAS/STING signaling pathway, cellular response to insulin stimulus, double-strand break repair, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, ectopic germ cell programmed cell death, heart development, immature B cell differentiation, immune system process, immunoglobulin V(D)J recombination, innate immune response, intrinsic apoptotic signaling pathway in response to DNA damage, lymphocyte differentiation, maturation of 5.8S rRNA, mitotic G1 DNA damage checkpoint signaling, negative regulation of apoptotic process, negative regulation of cGAS/STING signaling pathway, negative regulation of cellular senescence, negative regulation of immunoglobulin production, negative regulation of protein phosphorylation, negative regulation of response to gamma radiation, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of apoptotic process, positive regulation of biosynthetic process, positive regulation of developmental growth, positive regulation of double-strand break repair via nonhomologous end joining, positive regulation of erythrocyte differentiation, positive regulation of fibroblast proliferation, positive regulation of immune system process, positive regulation of lymphocyte differentiation, positive regulation of platelet formation, positive regulation of transcription by RNA polymerase II, positive regulation of translation, pro-B cell differentiation, protein destabilization, protein localization to chromatin, regulation of circadian rhythm, regulation of epithelial cell proliferation, regulation of hematopoietic stem cell differentiation, regulation of smooth muscle cell proliferation, replication fork processing, response to activity, response to gamma radiation, response to ionizing radiation, rhythmic process, ribosome biogenesis, small-subunit processome assembly, somitogenesis, spleen development, telomere capping, telomere maintenance, thymus development; MF: ATP binding, DNA-dependent protein kinase activity, RNA polymerase II-specific DNA-binding transcription factor binding, U3 snoRNA binding, double-stranded DNA binding, enzyme binding, histone H2AXS139 kinase activity, kinase activity, nucleotide binding, protein binding, protein domain specific binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: DNA-dependent protein kinase complex, DNA-dependent protein kinase-DNA ligase 4 complex, chromatin, cytoplasm, cytosol, nonhomologous end joining complex, nucleolus, nucleoplasm, nucleus, protein-DNA complex, protein-containing complex, small-subunit processome, transcription regulator complex
Pathways: Cell cycle - Mus musculus (mouse), DNA Double-Strand Break Repair, DNA Repair, E3 ubiquitin ligases ubiquitinate target proteins, Metabolism of proteins, Non-homologous end-joining - Mus musculus (mouse), Nonhomologous End-Joining (NHEJ), Post-translational protein modification, Protein ubiquitination
UniProt: P97313
Entrez ID: 19090
|
Does Knockout of Snx9 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Snx9
|
phagocytosis
|
macrophage
|
Gene: Snx9 (sorting nexin 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, cleavage furrow formation, endocytosis, endosomal transport, intracellular protein transport, lipid tube assembly, mitotic cell cycle, mitotic cytokinesis, plasma membrane tubulation, positive regulation of GTPase activity, positive regulation of actin filament polymerization, positive regulation of membrane protein ectodomain proteolysis, protein transport, protein-containing complex assembly, receptor-mediated endocytosis, regulation of synaptic vesicle endocytosis; MF: 1-phosphatidylinositol binding, Arp2/3 complex binding, identical protein binding, lipid binding, phosphatidylinositol binding, protein binding, protein homodimerization activity, ubiquitin protein ligase binding; CC: Golgi apparatus, cell projection, clathrin-coated pit, clathrin-coated vesicle, cuticular plate, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, membrane, plasma membrane, presynapse, ruffle, trans-Golgi network
Pathways: Clathrin-mediated endocytosis, Golgi Associated Vesicle Biogenesis, Membrane Trafficking, Salmonella infection - Mus musculus (mouse), Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q91VH2
Entrez ID: 66616
|
Does Knockout of Ahdc1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Ahdc1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ahdc1 (AT hook, DNA binding motif, containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell differentiation, mesoderm formation, regulation of DNA-templated transcription, skin morphogenesis; MF: DNA binding, DNA-binding transcription factor activity, molecular_function, promoter-enhancer loop anchoring activity; CC: cellular_component, chromosome, nucleus
Pathways:
UniProt: Q6PAL7
Entrez ID: 230793
|
Does Knockout of Tmem184b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Tmem184b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tmem184b (transmembrane protein 184b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane
Pathways:
UniProt: Q8BG09
Entrez ID: 223693
|
Does Knockout of Taok3 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,542
|
Knockout
|
Taok3
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Taok3 (TAO kinase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, MAPK cascade, mitotic G2 DNA damage checkpoint signaling, negative regulation of JNK cascade, neuron projection morphogenesis, positive regulation of JNK cascade, positive regulation of stress-activated MAPK cascade, regulation of MAPK cascade; MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, lipid droplet, membrane, membrane raft, plasma membrane
Pathways: MAPK signaling pathway - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8BYC6
Entrez ID: 330177
|
Does Knockout of Pik3c2b in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Pik3c2b
|
cell proliferation
|
Regulatory T cell
|
Gene: Pik3c2b (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome organization, cell migration, cellular response to starvation, lipid metabolic process, macroautophagy, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol-mediated signaling; MF: 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding, kinase activity, lipid kinase activity, nucleotide binding, phosphatidylinositol binding, protein binding, transferase activity; CC: cytoplasm, cytosol, endocytic vesicle, membrane, nuclear membrane, nucleoplasm, nucleus, plasma membrane
Pathways: 3-phosphoinositide biosynthesis, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, PI Metabolism, PIP metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, Salmonella infection - Mus musculus (mouse), Synthesis of PIPs at the plasma membrane
UniProt: A0A6I8MWY4, E9QAN8, D3Z091
Entrez ID: 240752
|
Does Knockout of Mvb12a in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Mvb12a
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Mvb12a (multivesicular body subunit 12A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endosome to lysosome transport via multivesicular body sorting pathway, protein transport, receptor catabolic process, regulation of epidermal growth factor receptor signaling pathway, viral budding, virus maturation; MF: SH3 domain binding, lipid binding, ubiquitin binding; CC: ESCRT I complex, centrosome, cytoplasm, cytoskeleton, cytosol, endosome, late endosome membrane, membrane, nucleus, vesicle
Pathways: Endocytosis - Mus musculus (mouse), Endosomal Sorting Complex Required For Transport (ESCRT), Membrane Trafficking, Vesicle-mediated transport
UniProt: Q78HU3
Entrez ID: 73711
|
Does Knockout of Dram2 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Dram2
|
phagocytosis
|
macrophage
|
Gene: Dram2 (DNA-damage regulated autophagy modulator 2)
Type: protein-coding
Summary: Involved in photoreceptor cell maintenance. Acts upstream of or within cell population proliferation; phloem or xylem histogenesis; and retina development in camera-type eye. Located in apical plasma membrane and photoreceptor inner segment. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system gland; and nervous system. Used to study cone-rod dystrophy. Human ortholog(s) of this gene implicated in cone-rod dystrophy 21. Orthologous to human DRAM2 (DNA damage regulated autophagy modulator 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: apoptotic process, autophagy, cell population proliferation, phloem or xylem histogenesis, photoreceptor cell maintenance, regulation of autophagy, retina development in camera-type eye, visual perception; CC: Golgi apparatus, apical plasma membrane, cytoplasm, lysosomal membrane, lysosome, membrane, photoreceptor inner segment, plasma membrane
Pathways:
UniProt: Q9CR48
Entrez ID: 67171
|
Does Knockout of Rax in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Rax
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rax (retina and anterior neural fold homeobox)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, camera-type eye development, hypothalamus development, limb development, pattern specification process, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding
Pathways:
UniProt: O35602
Entrez ID: 19434
|
Does Knockout of Tle4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Tle4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tle4 (transducin-like enhancer of split 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, cellular response to leukemia inhibitory factor, negative regulation of DNA-templated transcription, negative regulation of canonical Wnt signaling pathway, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription; MF: DNA-binding transcription factor binding, chromatin binding, protein binding, transcription corepressor activity; CC: beta-catenin-TCF complex, nucleoplasm, nucleus, transcription regulator complex
Pathways: Deactivation of the beta-catenin transactivating complex, Degradation of beta-catenin by the destruction complex, Formation of the beta-catenin:TCF transactivating complex, Notch signaling pathway - Mus musculus (mouse), Repression of WNT target genes, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q62441
Entrez ID: 21888
|
Does Knockout of Scn1b in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Scn1b
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Scn1b (sodium channel, voltage-gated, type I, beta)
Type: protein-coding
Summary: Enables sodium channel inhibitor activity. Involved in several processes, including membrane depolarization during cardiac muscle cell action potential; regulation of sodium ion transport; and regulation of ventricular cardiac muscle cell membrane repolarization. Acts upstream of or within several processes, including corticospinal neuron axon guidance; neuronal action potential propagation; and positive regulation of neuron projection development. Located in T-tubule; intercalated disc; and node of Ranvier. Part of voltage-gated sodium channel complex. Is expressed in heart and telencephalon. Used to study generalized epilepsy with febrile seizures plus. Human ortholog(s) of this gene implicated in Brugada syndrome 5; developmental and epileptic encephalopathy 52; familial atrial fibrillation; and generalized epilepsy with febrile seizures plus 1. Orthologous to human SCN1B (sodium voltage-gated channel beta subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: axon guidance, cardiac conduction, cardiac muscle cell action potential involved in contraction, cardiac muscle contraction, corticospinal neuron axon guidance, locomotion, membrane depolarization, membrane depolarization during Purkinje myocyte cell action potential, membrane depolarization during action potential, membrane depolarization during cardiac muscle cell action potential, monoatomic ion transport, neuronal action potential propagation, positive regulation of neuron projection development, positive regulation of sodium ion transport, positive regulation of voltage-gated sodium channel activity, regulation of atrial cardiac muscle cell membrane depolarization, regulation of heart rate by cardiac conduction, regulation of sodium ion transmembrane transport, regulation of sodium ion transport, regulation of ventricular cardiac muscle cell membrane repolarization, response to pyrethroid, sodium ion transmembrane transport, sodium ion transport; MF: protein binding, sodium channel inhibitor activity, sodium channel regulator activity, transmembrane transporter binding; CC: T-tubule, axon, cell projection, intercalated disc, membrane, node of Ranvier, perikaryon, plasma membrane, sodium channel complex, voltage-gated sodium channel complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse)
UniProt: P97952
Entrez ID: 20266
|
Does Knockout of Adar in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Adar
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Adar (adenosine deaminase, RNA-specific)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RISC complex assembly, RNA processing, adenosine to inosine editing, base conversion or substitution editing, cellular response to virus, defense response to virus, definitive hemopoiesis, erythrocyte differentiation, hematopoietic progenitor cell differentiation, hematopoietic stem cell homeostasis, immune system process, in utero embryonic development, innate immune response, mRNA processing, miRNA processing, negative regulation of hepatocyte apoptotic process, negative regulation of post-transcriptional gene silencing by regulatory ncRNA, negative regulation of protein kinase activity by regulation of protein phosphorylation, negative regulation of type I interferon-mediated signaling pathway, negative regulation of viral genome replication, osteoblast differentiation, positive regulation of viral genome replication, pre-miRNA processing, protein export from nucleus, protein import into nucleus, regulatory ncRNA-mediated gene silencing, response to interferon-alpha, response to virus, somatic diversification of immune receptors via somatic mutation; MF: DNA binding, RNA binding, adenosine deaminase activity, double-stranded RNA adenosine deaminase activity, double-stranded RNA binding, hydrolase activity, left-handed Z-DNA binding, metal ion binding, protein binding, tRNA-specific adenosine deaminase activity; CC: cytoplasm, nuclear lumen, nuclear speck, nucleolus, nucleoplasm, nucleus, supraspliceosomal complex
Pathways: Antiviral mechanism by IFN-stimulated genes, C6 deamination of adenosine, Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytosolic DNA-sensing pathway - Mus musculus (mouse), Formation of editosomes by ADAR proteins, Immune System, Influenza A - Mus musculus (mouse), Interferon Signaling, Measles - Mus musculus (mouse), Metabolism of RNA, PKR-mediated signaling, mRNA Editing, mRNA Editing: A to I Conversion
UniProt: Q99MU3
Entrez ID: 56417
|
Does Knockout of Rhpn1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Rhpn1
|
cell cycle progression
|
breast epithelium
|
Gene: Rhpn1 (rhophilin, Rho GTPase binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: focal adhesion assembly, glomerular filtration, kidney development, negative regulation of stress fiber assembly, plasma membrane bounded cell projection morphogenesis, renal albumin absorption, signal transduction; CC: cell periphery, cytosol, plasma membrane
Pathways: RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Rhotekin and Rhophilins, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q61085
Entrez ID: 14787
|
Does Knockout of Zfp185 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Zfp185
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp185 (zinc finger protein 185)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: anchoring junction, cytoplasm, cytoskeleton, focal adhesion
Pathways:
UniProt: Q62394
Entrez ID: 22673
|
Does Knockout of Ppp1r14b in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Ppp1r14b
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ppp1r14b (protein phosphatase 1, regulatory inhibitor subunit 14B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: phosphatase inhibitor activity, protein phosphatase inhibitor activity, protein phosphatase regulator activity, protein serine/threonine phosphatase inhibitor activity
Pathways:
UniProt: Q62084
Entrez ID: 18938
|
Does Knockout of Terb2 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Terb2
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Terb2 (telomere repeat binding bouquet formation protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: double-strand break repair involved in meiotic recombination, homologous chromosome pairing at meiosis, meiotic attachment of telomere to nuclear envelope, meiotic cell cycle, meiotic telomere clustering, oogenesis, spermatogenesis, synaptonemal complex assembly; CC: chromosome, chromosome, telomeric region, membrane, nuclear envelope, nuclear inner membrane, nucleus
Pathways:
UniProt: Q9D494
Entrez ID: 74401
|
Does Knockout of Hnrnpf in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Hnrnpf
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Hnrnpf (heterogeneous nuclear ribonucleoprotein F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, regulation of RNA splicing; MF: RNA binding, TBP-class protein binding, nucleic acid binding, single-stranded RNA binding; CC: catalytic step 2 spliceosome, cytosol, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex, synapse
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9Z2X1
Entrez ID: 98758
|
Does Knockout of 1700008O03Rik in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
1700008O03Rik
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: 1700008O03Rik (RIKEN cDNA 1700008O03 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: D3Z070
Entrez ID: 69349
|
Does Knockout of Actrt3 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Actrt3
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Actrt3 (actin related protein T3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: actin cytoskeleton, cytoplasm, cytoskeleton, male germ cell nucleus, nucleus
Pathways:
UniProt: Q8BXF8
Entrez ID: 76652
|
Does Knockout of Tdg in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Tdg
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tdg (thymine DNA glycosylase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, base-excision repair, base-excision repair, AP site formation, chromatin organization, epigenetic regulation of gene expression, negative regulation of transcription by RNA polymerase II, regulation of embryonic development; MF: ATP binding, DNA N-glycosylase activity, DNA binding, DNA-binding transcription factor binding, G/T mismatch-specific thymine-DNA glycosylase activity, G/U mismatch-specific uracil-DNA glycosylase activity, SUMO binding, chloride ion binding, double-stranded DNA binding, hydrolase activity, magnesium ion binding, mismatch base pair DNA N-glycosylase activity, mismatched DNA binding, nucleic acid binding, protein binding, protein domain specific binding, protein kinase C binding, pyrimidine-specific mismatch base pair DNA N-glycosylase activity, sodium ion binding, transcription coregulator activity, uracil DNA N-glycosylase activity; CC: PML body, nucleoplasm, nucleus, plasma membrane
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Base-Excision Repair, AP Site Formation, Cleavage of the damaged pyrimidine , DNA Repair, Depyrimidination, Displacement of DNA glycosylase by APEX1, Epigenetic regulation of gene expression, Gene expression (Transcription), Metabolism of proteins, Post-translational protein modification, Resolution of Abasic Sites (AP sites), SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, TET1,2,3 and TDG demethylate DNA
UniProt: P56581
Entrez ID: 21665
|
Does Knockout of Nlrp6 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Nlrp6
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Nlrp6 (NLR family, pyrin domain containing 6)
Type: protein-coding
Summary: The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. [provided by RefSeq, Feb 2013].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, NLRP6 inflammasome complex assembly, acute inflammatory response, acute inflammatory response to antigenic stimulus, antiviral innate immune response, defense response to Gram-positive bacterium, defense response to virus, establishment of localization in cell, host-mediated modulation of intestinal microbiota composition, immune system process, inflammatory response, innate immune response, interleukin-1-mediated signaling pathway, interleukin-18-mediated signaling pathway, necroptotic process, negative regulation of ERK1 and ERK2 cascade, negative regulation of MAPK cascade, negative regulation of canonical NF-kappaB signal transduction, negative regulation of immune response, negative regulation of inflammatory response to antigenic stimulus, negative regulation of toll-like receptor signaling pathway, negative regulation of type II interferon production, neutrophil-mediated killing of gram-positive bacterium, positive regulation of inflammatory response, positive regulation of interleukin-1 beta production, positive regulation of interleukin-18 production, positive regulation of interleukin-18-mediated signaling pathway, protein homooligomerization, protein maturation, protein secretion, pyroptotic inflammatory response, regulation of autophagy, regulation of inflammatory response, regulation of mucus secretion, response to bacterium, signal transduction, wound healing; MF: ATP binding, double-stranded RNA binding, lipopolysaccharide binding, lipoteichoic acid binding, molecular condensate scaffold activity, nucleotide binding, pattern recognition receptor activity, peptide binding, protein binding, signaling adaptor activity, signaling receptor activity, vasopressin receptor activity; CC: NLRP6 inflammasome complex, canonical inflammasome complex, cytoplasm, cytosol, membrane, membraneless organelle, nuclear membrane, nucleus, plasma membrane
Pathways: NOD-like receptor signaling pathway - Mus musculus (mouse)
UniProt: Q91WS2
Entrez ID: 101613
|
Does Knockout of Slc39a7 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Slc39a7
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Slc39a7 (solute carrier family 39 (zinc transporter), member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, intracellular zinc ion homeostasis, metal ion transport, monoatomic ion transport, regulation of ferroptosis, skin epidermis development, transmembrane transport, zinc ion transmembrane transport, zinc ion transport; MF: metal ion transmembrane transporter activity, protein binding, zinc ion transmembrane transporter activity; CC: Golgi apparatus, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleoplasm
Pathways: Alzheimer disease - Mus musculus (mouse), Metal ion SLC transporters, Parkinson disease - Mus musculus (mouse), SLC-mediated transmembrane transport, Transport of small molecules, Zinc influx into cells by the SLC39 gene family, Zinc transporters
UniProt: Q31125
Entrez ID: 14977
|
Does Knockout of Gm6710 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Gm6710
|
cell cycle progression
|
breast epithelium
|
Gene: Gm6710 (predicted gene 6710)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: Q8C1K5, A2ART0, A2ARX2, A2ARX1
Entrez ID: 626832
|
Does Knockout of Atp6v0e2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Atp6v0e2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Atp6v0e2 (ATPase, H+ transporting, lysosomal V0 subunit E2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport, synaptic vesicle lumen acidification, transmembrane transport; MF: proton-transporting ATPase activity, rotational mechanism; CC: clathrin-coated vesicle membrane, cytoplasmic vesicle, membrane, proton-transporting V-type ATPase, V0 domain, synapse, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase, V0 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules
UniProt: Q91XE7
Entrez ID: 76252
|
Does Knockout of Htr4 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Htr4
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Htr4 (5 hydroxytryptamine (serotonin) receptor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-activating serotonin receptor signaling pathway, adenylate cyclase-inhibiting serotonin receptor signaling pathway, chemical synaptic transmission, gamma-aminobutyric acid signaling pathway, large intestinal transit, maintenance of gastrointestinal epithelium, mucus secretion, regulation of appetite, regulation of postsynapse assembly, signal transduction, system process; MF: G protein-coupled receptor activity, G protein-coupled serotonin receptor activity, neurotransmitter receptor activity, protein binding, serotonin binding, serotonin receptor activity; CC: cytoplasm, dendrite, endosome, endosome membrane, glutamatergic synapse, membrane, plasma membrane, postsynapse
Pathways: Amine ligand-binding receptors, Calcium signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Serotonin receptors, Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse)
UniProt: P97288
Entrez ID: 15562
|
Does Knockout of Apoc3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Apoc3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Apoc3 (apolipoprotein C-III)
Type: protein-coding
Summary: This gene encodes an apolipoprotein which is the major protein component of very-low-density lipoproteins (VLDL) and a minor component of high-density lipoproteins (HDL). The encoded protein is thought to regulate the metabolism of triglyceride-rich lipoproteins and play a role in lipid storage and the mobilization of fat cells. This gene is clustered with three other apolipoprotein genes on chromosome 9 and is associated with coronary disease. Mice lacking this gene have lower levels of total cholesterol in the plasma. Mutations in the human genes causes hyperalphalipoproteinemia 2, a disorder of lipid metabolism which results in a favorable lipid profile (lower LDL-cholesterol, higher HDL-cholesterol and lower levels of serum triglycerides when fasting and after a meal). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cellular response to glucose stimulus, cholesterol efflux, cholesterol homeostasis, cholesterol metabolic process, chylomicron remnant clearance, high-density lipoprotein particle remodeling, lipid catabolic process, lipid metabolic process, lipid transport, lipoprotein metabolic process, lipoprotein transport, negative regulation of cholesterol import, negative regulation of fatty acid biosynthetic process, negative regulation of high-density lipoprotein particle clearance, negative regulation of lipid catabolic process, negative regulation of lipid metabolic process, negative regulation of low-density lipoprotein particle clearance, negative regulation of oxidative phosphorylation, negative regulation of receptor-mediated endocytosis, negative regulation of triglyceride catabolic process, negative regulation of very-low-density lipoprotein particle clearance, negative regulation of very-low-density lipoprotein particle remodeling, phospholipid efflux, positive regulation of triglyceride biosynthetic process, regulation of Cdc42 protein signal transduction, response to peptide hormone, triglyceride catabolic process, triglyceride homeostasis, triglyceride metabolic process, triglyceride mobilization; MF: high-density lipoprotein particle receptor binding, lipase inhibitor activity, lipid binding, phospholipid binding; CC: chylomicron, cytosol, extracellular region, extracellular space, intermediate-density lipoprotein particle, spherical high-density lipoprotein particle, very-low-density lipoprotein particle
Pathways: Cholesterol metabolism - Mus musculus (mouse), Chylomicron assembly, Chylomicron remodeling, HDL remodeling, Metabolism, Metabolism of fat-soluble vitamins, Metabolism of vitamins and cofactors, PPAR signaling pathway - Mus musculus (mouse), Plasma lipoprotein assembly, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein remodeling, Retinoid metabolism and transport, Sensory Perception, Transport of small molecules, Visual phototransduction
UniProt: P33622
Entrez ID: 11814
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