prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Acot8 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Acot8
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Acot8 (acyl-CoA thioesterase 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acyl-CoA metabolic process, alpha-linolenic acid metabolic process, dicarboxylic acid catabolic process, fatty acid catabolic process, fatty acid derivative biosynthetic process, fatty acid metabolic process, lipid metabolic process, long-chain fatty acid biosynthetic process, negative regulation of glycoprotein biosynthetic process, peroxisome fission, peroxisome organization, unsaturated fatty acid biosynthetic process; MF: acetoacetyl-CoA hydrolase activity, acetyl-CoA hydrolase activity, carboxylic ester hydrolase activity, choloyl-CoA hydrolase activity, fatty acyl-CoA hydrolase activity, hydrolase activity, hydroxymethylglutaryl-CoA hydrolase activity, long-chain fatty acyl-CoA hydrolase activity, medium-chain fatty acyl-CoA hydrolase activity, succinyl-CoA hydrolase activity; CC: mitochondrion, peroxisomal matrix, peroxisome
Pathways: Beta-oxidation of pristanoyl-CoA, Beta-oxidation of very long chain fatty acids, Bile acid and bile salt metabolism, Fatty acid metabolism, Metabolism, Metabolism of lipids, Metabolism of steroids, Peroxisomal lipid metabolism, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Primary bile acid biosynthesis - Mus musculus (mouse), Protein localization, Synthesis of bile acids and bile salts, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, acyl-CoA hydrolysis, alpha-linolenic (omega3) and linoleic (omega6) acid metabolism, alpha-linolenic acid (ALA) metabolism
UniProt: P58137
Entrez ID: 170789
|
Does Knockout of Mir7087 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Mir7087
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Mir7087 (microRNA 7087)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102465659
|
Does Knockout of Ago3 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Ago3
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Ago3 (argonaute RISC catalytic subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RISC complex assembly, mRNA catabolic process, miRNA processing, miRNA-mediated gene silencing by inhibition of translation, miRNA-mediated gene silencing by mRNA destabilization, positive regulation of gene expression, positive regulation of non-canonical NF-kappaB signal transduction, pre-miRNA processing, regulation of stem cell proliferation, regulation of translation, regulatory ncRNA-mediated gene silencing, regulatory ncRNA-mediated post-transcriptional gene silencing; MF: RNA binding, RNA endonuclease activity, double-stranded RNA binding, endonuclease activity, endoribonuclease activity, cleaving miRNA-paired mRNA, hydrolase activity, metal ion binding, miRNA binding, nuclease activity, nucleic acid binding, single-stranded RNA binding; CC: P-body, RISC complex, RISC-loading complex, condensed nuclear chromosome, cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Gene Silencing by RNA, Gene expression (Transcription), MicroRNA (miRNA) biogenesis, Post-transcriptional silencing by small RNAs, Small interfering RNA (siRNA) biogenesis
UniProt: Q8CJF9
Entrez ID: 214150
|
Does Knockout of Sirt6 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,546
|
Knockout
|
Sirt6
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Sirt6 (sirtuin 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, Ras protein signal transduction, base-excision repair, cardiac muscle cell differentiation, cellular response to angiotensin, cellular response to endothelin, cellular response to hydrogen peroxide, chromatin organization, chromatin remodeling, circadian regulation of gene expression, determination of adult lifespan, double-strand break repair, gluconeogenesis, glucose homeostasis, glycolytic process, inflammatory response, ketone biosynthetic process, negative regulation of D-glucose import, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of cellular senescence, negative regulation of gene expression, epigenetic, negative regulation of gluconeogenesis, negative regulation of glycolytic process, negative regulation of protein import into nucleus, negative regulation of protein localization to chromatin, negative regulation of transcription by RNA polymerase II, negative regulation of transcription elongation by RNA polymerase II, pericentric heterochromatin formation, positive regulation of blood vessel branching, positive regulation of cellular senescence, positive regulation of chondrocyte proliferation, positive regulation of cold-induced thermogenesis, positive regulation of double-strand break repair, positive regulation of fat cell differentiation, positive regulation of fibroblast proliferation, positive regulation of gluconeogenesis, positive regulation of insulin secretion, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein export from nucleus, positive regulation of protein localization to chromatin, positive regulation of stem cell differentiation, positive regulation of stem cell population maintenance, positive regulation of stem cell proliferation, positive regulation of telomere maintenance, positive regulation of transcription by RNA polymerase II, positive regulation of vascular endothelial cell proliferation, post-embryonic cardiac muscle cell growth involved in heart morphogenesis, protein deacetylation, protein delipidation, protein destabilization, protein import into nucleus, protein localization to site of double-strand break, protein poly-ADP-ribosylation, regulation of circadian rhythm, regulation of double-strand break repair via homologous recombination, regulation of lipid catabolic process, regulation of lipid metabolic process, regulation of protein export from nucleus, regulation of protein localization to plasma membrane, regulation of protein secretion, response to UV, response to nutrient levels, subtelomeric heterochromatin formation, transcription pausing by RNA polymerase II, transposable element silencing; MF: DNA binding, DNA damage sensor activity, NAD+ binding, NAD+-protein mono-ADP-ribosyltransferase activity, NAD+-protein-arginine ADP-ribosyltransferase activity, NAD+-protein-lysine ADP-ribosyltransferase activity, NAD-dependent protein demyristoylase activity, NAD-dependent protein depalmitoylase activity, NAD-dependent protein lysine deacetylase activity, RNA binding, TORC2 complex binding, acyltransferase activity, chromatin DNA binding, chromatin binding, damaged DNA binding, enzyme regulator activity, glycosyltransferase activity, histone H3K18 deacetylase activity, NAD-dependent, histone H3K56 deacetylase activity, NAD-dependent, histone H3K9 deacetylase activity, NAD-dependent, histone H3K9 deacetylase activity, hydrolytic mechanism, histone deacetylase activity, NAD-dependent, histone deacetylase regulator activity, lncRNA binding, metal ion binding, nucleosome binding, nucleotidyltransferase activity, protein homodimerization activity, protein lysine deacetylase activity, transcription corepressor activity, transferase activity, zinc ion binding; CC: chromatin, chromosome, chromosome, subtelomeric region, chromosome, telomeric region, endoplasmic reticulum, nucleolus, nucleoplasm, nucleus, pericentric heterochromatin, site of DNA damage, site of double-strand break
Pathways: Central carbon metabolism in cancer - Mus musculus (mouse), DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Processing of DNA double-strand break ends, Thermogenesis - Mus musculus (mouse)
UniProt: P59941
Entrez ID: 50721
|
Does Knockout of Bcl6 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Bcl6
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Bcl6 (B cell leukemia/lymphoma 6)
Type: protein-coding
Summary: Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of lymphocyte activation. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Human ortholog(s) of this gene implicated in B-cell lymphoma and diffuse large B-cell lymphoma. Orthologous to human BCL6 (BCL6 transcription repressor). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: B cell differentiation, DNA damage response, Rho protein signal transduction, actin cytoskeleton organization, cell morphogenesis, erythrocyte development, germinal center formation, heterochromatin formation, immune system process, inflammatory response, intracellular protein localization, memory T cell proliferation, negative regulation of DNA-templated transcription, negative regulation of Notch signaling pathway, negative regulation of Rho protein signal transduction, negative regulation of T-helper 2 cell differentiation, negative regulation of apoptotic process, negative regulation of cell growth, negative regulation of cell-matrix adhesion, negative regulation of cellular senescence, negative regulation of isotype switching to IgE isotypes, negative regulation of mast cell cytokine production, negative regulation of mononuclear cell proliferation, negative regulation of plasma cell differentiation, negative regulation of transcription by RNA polymerase II, negative regulation of type 2 immune response, positive regulation of B cell proliferation, positive regulation of apoptotic process, positive regulation of cell differentiation, positive regulation of cell motility, positive regulation of lymphocyte activation, positive regulation of neuron differentiation, positive regulation of regulatory T cell differentiation, pyramidal neuron differentiation, regulation of T cell differentiation, regulation of T cell proliferation, regulation of apoptotic process, regulation of cell differentiation, regulation of cell population proliferation, regulation of cytokine production, regulation of immune system process, regulation of inflammatory response, regulation of leukocyte cell-cell adhesion, regulation of memory T cell differentiation, regulation of transcription by RNA polymerase II, spermatogenesis, type 2 immune response; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding, identical protein binding, intronic transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription corepressor binding, zinc ion binding; CC: Golgi apparatus, nucleolus, nucleoplasm, nucleus, paraspeckles, replication fork
Pathways: Chemical carcinogenesis - receptor activation - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: P41183
Entrez ID: 12053
|
Does Knockout of Scgb1b7 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Scgb1b7
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Scgb1b7 (secretoglobin, family 1B, member 7)
Type: protein-coding
Summary: Predicted to enable steroid binding activity. Predicted to be active in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: molecular_function, steroid binding; CC: extracellular region
Pathways:
UniProt: D2XZ31
Entrez ID: 626305
|
Does Knockout of Ctxn3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Ctxn3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Ctxn3 (cortexin 3)
Type: protein-coding
Summary: Predicted to be located in membrane. Is expressed in genitourinary system and otocyst. Orthologous to human CTXN3 (cortexin 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8BXZ0
Entrez ID: 629147
|
Does Knockout of Gns in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Gns
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Gns (glucosamine (N-acetyl)-6-sulfatase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glycosaminoglycan metabolic process, heparan sulfate proteoglycan catabolic process, keratan sulfate proteoglycan catabolic process; MF: N-acetylglucosamine-6-sulfatase activity, glycosaminoglycan binding, hydrolase activity, metal ion binding, sulfate binding, sulfuric ester hydrolase activity; CC: azurophil granule, lysosome
Pathways: Glycosaminoglycan degradation - Mus musculus (mouse), Glycosaminoglycan metabolism, Immune System, Innate Immune System, Keratan sulfate degradation, Keratan sulfate/keratin metabolism, Lysosome - Mus musculus (mouse), Lysosome Vesicle Biogenesis, Membrane Trafficking, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Neutrophil degranulation, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q8BFR4
Entrez ID: 75612
|
Does Knockout of Dnaja1 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Dnaja1
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Dnaja1 (DnaJ heat shock protein family (Hsp40) member A1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the DnaJ family, whose members act as cochaperones of heat shock protein 70. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. Mice deficient for this gene display reduced levels of activation‐induced deaminase, an enzyme that deaminates deoxycytidine at the immunoglobulin genes during immune responses. In addition, mice lacking this gene exhibit severe defects in spermatogenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: androgen receptor signaling pathway, flagellated sperm motility, negative regulation of JUN kinase activity, negative regulation of apoptotic process, negative regulation of establishment of protein localization to mitochondrion, negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway, negative regulation of protein ubiquitination, positive regulation of apoptotic process, protein folding, protein localization to mitochondrion, protein refolding, regulation of protein transport, response to heat, spermatogenesis; MF: ATP binding, ATPase activator activity, C3HC4-type RING finger domain binding, G protein-coupled receptor binding, Hsp70 protein binding, Tat protein binding, heat shock protein binding, low-density lipoprotein particle receptor binding, metal ion binding, protein binding, protein-folding chaperone binding, ubiquitin protein ligase binding, unfolded protein binding, zinc ion binding; CC: cytoplasm, cytosol, endoplasmic reticulum, membrane, microtubule cytoskeleton, mitochondrion, nucleus, perinuclear region of cytoplasm
Pathways: Cellular responses to stimuli, Cellular responses to stress, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Mitochondrial unfolded protein response (UPRmt), Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: P63037
Entrez ID: 15502
|
Does Knockout of Was in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Was
|
response to bacteria
|
renal medulla cell line
|
Gene: Was (Wiskott-Aldrich syndrome)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Cdc42 protein signal transduction, T cell activation, actin filament organization, actin filament polymerization, actin filament-based movement, actin polymerization or depolymerization, cellular response to type II interferon, defense response, endosomal transport, immune response, negative regulation of cell motility, negative regulation of stress fiber assembly, positive regulation of double-strand break repair via homologous recombination, positive regulation of transcription by RNA polymerase II, regulation of T cell antigen processing and presentation, regulation of actin polymerization or depolymerization, regulation of double-strand break repair via nonhomologous end joining, regulation of lamellipodium assembly, regulation of stress fiber assembly; MF: SH3 domain binding, actin binding, identical protein binding, phospholipase binding, protein binding, protein kinase binding, small GTPase binding; CC: actin filament, cell-cell junction, cytoplasm, cytoskeleton, cytosol, membrane, nucleus, phagocytic vesicle, plasma membrane, site of double-strand break, vesicle membrane
Pathways: Adherens junction - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse)
UniProt: P70315
Entrez ID: 22376
|
Does Knockout of Rxfp2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Rxfp2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rxfp2 (relaxin/insulin-like family peptide receptor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, hormone-mediated signaling pathway, male gonad development, negative regulation of apoptotic process, negative regulation of cell population proliferation, oocyte maturation, signal transduction; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, peptide hormone binding, protein-hormone receptor activity; CC: membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Relaxin receptors, Relaxin signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q91ZZ5
Entrez ID: 140498
|
Does Knockout of Pstpip2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Pstpip2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Pstpip2 (proline-serine-threonine phosphatase-interacting protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: actin binding, protein binding; CC: cytoplasm, cytoskeleton, cytosol, membrane, plasma membrane
Pathways:
UniProt: Q99M15
Entrez ID: 19201
|
Does Knockout of Asb2 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Asb2
|
response to virus
|
Microglial Cell Line
|
Gene: Asb2 (ankyrin repeat and SOCS box-containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, cardiac muscle cell development, cardiac muscle cell differentiation, dendritic cell migration, heart development, heart looping, intracellular signal transduction, myoblast differentiation, podosome assembly, proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination, protein ubiquitination, skeletal muscle atrophy, skeletal muscle cell differentiation, ubiquitin-dependent protein catabolic process; MF: cullin family protein binding, protein binding, ubiquitin protein ligase activity; CC: Cul5-RING ubiquitin ligase complex, Z disc, cytoplasm, cytoskeleton, stress fiber, ubiquitin ligase complex
Pathways:
UniProt: Q8K0L0
Entrez ID: 65256
|
Does Knockout of Cdk9 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Cdk9
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Cdk9 (cyclin dependent kinase 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, cellular response to cytokine stimulus, host-mediated activation of viral transcription, negative regulation of protein localization to chromatin, negative regulation of transcription elongation by RNA polymerase II, nucleus localization, positive regulation of cardiac muscle hypertrophy, positive regulation of protein localization to chromatin, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of DNA repair, regulation of cell cycle, regulation of mRNA 3'-end processing, regulation of muscle cell differentiation, replication fork processing, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, transcription elongation-coupled chromatin remodeling, transcription pausing by RNA polymerase II; MF: 7SK snRNA binding, ATP binding, DNA binding, RNA polymerase II CTD heptapeptide repeat kinase activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, snRNA binding, transcription cis-regulatory region binding, transcription coactivator binding, transcription elongation factor activity, transferase activity; CC: P-TEFb complex, PML body, cyclin/CDK positive transcription elongation factor complex, cytoplasm, cytoplasmic ribonucleoprotein granule, nucleoplasm, nucleus, transcription elongation factor complex
Pathways: ESR-mediated signaling, Estrogen-dependent gene expression, Formation of RNA Pol II elongation complex , Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA polymerase II transcribes snRNA genes, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Signal Transduction, Signaling by Nuclear Receptors, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q99J95
Entrez ID: 107951
|
Does Knockout of 4931400O07Rik in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
4931400O07Rik
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: 4931400O07Rik (RIKEN cDNA 4931400O07 gene)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 70936
|
Does Knockout of Utp4 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Utp4
|
cell proliferation
|
Regulatory T cell
|
Gene: Utp4 (UTP4 small subunit processome component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of SSU-rRNA, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, regulation of DNA-templated transcription, ribosomal small subunit biogenesis, ribosome biogenesis; CC: 90S preribosome, chromosome, fibrillar center, nucleolus, nucleus, small-subunit processome, t-UTP complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8R2N2
Entrez ID: 21771
|
Does Knockout of Dph7 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Dph7
|
cell proliferation
|
Regulatory T cell
|
Gene: Dph7 (diphthamine biosynethesis 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein histidyl modification to diphthamide; MF: diphthine methylesterase activity, hydrolase activity, molecular_function, protein methylesterase activity; CC: cellular_component, cytoplasm
Pathways:
UniProt: Q9CYU6
Entrez ID: 67228
|
Does Knockout of Mfn1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Mfn1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Mfn1 (mitofusin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GTP metabolic process, intracellular distribution of mitochondria, mitochondrial fusion, mitochondrion localization, mitochondrion organization, negative regulation of mitochondrial fission, positive regulation of dendritic spine morphogenesis, positive regulation of mitochondrial fusion, positive regulation of mitochondrial membrane potential; MF: GTP binding, GTPase activity, hydrolase activity, identical protein binding, nucleotide binding, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrion, outer mitochondrial membrane protein complex
Pathways: Autophagy, Factors involved in megakaryocyte development and platelet production, Hemostasis, Macroautophagy, Miro GTPase Cycle, Mitophagy, Mitophagy - animal - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), PINK1-PRKN Mediated Mitophagy, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), RHOT2 GTPase cycle, Selective autophagy, Signal Transduction, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q811U4
Entrez ID: 67414
|
Does Knockout of Pex12 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,286
|
Knockout
|
Pex12
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pex12 (peroxisomal biogenesis factor 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to reactive oxygen species, peroxisome organization, pexophagy, protein import into peroxisome matrix, protein import into peroxisome matrix, receptor recycling, protein import into peroxisome matrix, substrate release, protein monoubiquitination, protein polyubiquitination, protein transport, protein ubiquitination, protein unfolding; MF: metal ion binding, ubiquitin ligase activator activity, ubiquitin-protein transferase activity, zinc ion binding; CC: membrane, peroxisomal importomer complex, peroxisomal membrane, peroxisome
Pathways: Class I peroxisomal membrane protein import, E3 ubiquitin ligases ubiquitinate target proteins, Metabolism of proteins, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Post-translational protein modification, Protein localization, Protein ubiquitination
UniProt: Q8VC48
Entrez ID: 103737
|
Does Knockout of Wdfy1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Wdfy1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Wdfy1 (WD repeat and FYVE domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of toll-like receptor 3 signaling pathway, positive regulation of toll-like receptor 4 signaling pathway; MF: 1-phosphatidylinositol binding, metal ion binding, protein binding, zinc ion binding; CC: Golgi apparatus, cell junction, cytosol, early endosome, endosome, nucleolus, nucleus
Pathways:
UniProt: E9Q4P1
Entrez ID: 69368
|
Does Knockout of Card10 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Card10
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Card10 (caspase recruitment domain family, member 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of NF-kappaB-inducing kinase activity, negative regulation of cell migration involved in sprouting angiogenesis, positive regulation of canonical NF-kappaB signal transduction, positive regulation of protein localization to nucleus, regulation of apoptotic process, regulation of immune response
Pathways: NF-kappa B signaling pathway - Mus musculus (mouse)
UniProt: P58660
Entrez ID: 105844
|
Does Knockout of Rorb in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Rorb
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rorb (RAR-related orphan receptor beta)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, amacrine cell differentiation, cellular response to retinoic acid, eye photoreceptor cell development, intracellular receptor signaling pathway, negative regulation of DNA-templated transcription, negative regulation of osteoblast differentiation, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of circadian rhythm, regulation of gene expression, regulation of transcription by RNA polymerase II, retina development in camera-type eye, retinal cone cell development, retinal rod cell development, retinal rod cell differentiation, rhythmic process, visual perception; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, melatonin receptor activity, metal ion binding, nuclear receptor activity, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways: Circadian rhythm - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Nuclear Receptor transcription pathway, RNA Polymerase II Transcription
UniProt: Q8R1B8
Entrez ID: 225998
|
Does Knockout of Dnase1l2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Dnase1l2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Dnase1l2 (deoxyribonuclease 1-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA catabolic process, corneocyte development, hair follicle development; MF: DNA binding, DNA nuclease activity, catalytic activity, deoxyribonuclease I activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity; CC: cytoplasm, extracellular region, nucleus
Pathways:
UniProt: Q9D1G0
Entrez ID: 66705
|
Does Knockout of Slc2a5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Slc2a5
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Slc2a5 (solute carrier family 2 (facilitated glucose transporter), member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-glucose import, D-glucose transmembrane transport, cellular response to fructose stimulus, dehydroascorbic acid transport, fructose import across plasma membrane, fructose transmembrane transport, regulation of systemic arterial blood pressure mediated by a chemical signal, response to fructose, transmembrane transport; MF: D-glucose transmembrane transporter activity, fructose binding, fructose transmembrane transporter activity, transmembrane transporter activity; CC: apical plasma membrane, membrane, plasma membrane, sarcolemma
Pathways: Carbohydrate digestion and absorption - Mus musculus (mouse), Digestion and absorption, Immune System, Innate Immune System, Intestinal absorption, Intestinal hexose absorption, Neutrophil degranulation
UniProt: Q9WV38
Entrez ID: 56485
|
Does Knockout of Glis3 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Glis3
|
phagocytosis
|
macrophage
|
Gene: Glis3 (GLIS family zinc finger 3)
Type: protein-coding
Summary: This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein which contains multiple C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the transcriptional regulation of insulin. It is thought to enhance GLI-RE-dependent transcription by binding to the GLI-RE consensus sequence (GACCACCCAC). Mutations in a similar gene in human have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015].
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q6XP49
Entrez ID: 226075
|
Does Knockout of Zfp472 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Zfp472
|
phagocytosis
|
macrophage
|
Gene: Zfp472 (zinc finger protein 472)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: B0V2W5, Q3UQI7, A0A3Q4EC37
Entrez ID: 224691
|
Does Knockout of Pde4c in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Pde4c
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pde4c (phosphodiesterase 4C, cAMP specific)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cAMP catabolic process, negative regulation of cAMP/PKA signal transduction, negative regulation of insulin secretion involved in cellular response to glucose stimulus, signal transduction; MF: 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, hydrolase activity, metal ion binding, phosphoric diester hydrolase activity; CC: cell projection, cilium
Pathways: DARPP-32 events, G alpha (i) signalling events, G alpha (s) signalling events, GPCR downstream signalling, Morphine addiction - Mus musculus (mouse), Opioid Signalling, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q3UEI1
Entrez ID: 110385
|
Does Knockout of Ell2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Ell2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ell2 (elongation factor for RNA polymerase II 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription elongation by RNA polymerase II, snRNA transcription by RNA polymerase II, transcription elongation by RNA polymerase II; CC: nucleoplasm, nucleus, transcription elongation factor complex
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q3UKU1
Entrez ID: 192657
|
Does Knockout of 4930558K02Rik in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
4930558K02Rik
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: 4930558K02Rik (RIKEN cDNA 4930558K02 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: E0CXC6
Entrez ID: 75368
|
Does Knockout of Slc5a11 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Slc5a11
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Slc5a11 (solute carrier family 5 (sodium/glucose cotransporter), member 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, carbohydrate transmembrane transport, hexose transmembrane transport, monoatomic ion transport, myo-inositol transport, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: D-glucose:sodium symporter activity, myo-inositol transmembrane transporter activity, symporter activity, transmembrane transporter activity; CC: apical plasma membrane, membrane, plasma membrane
Pathways: Inositol transporters, SLC-mediated transmembrane transport, Transport of small molecules
UniProt: Q8K0E3
Entrez ID: 233836
|
Does Knockout of Cep104 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Cep104
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cep104 (centrosomal protein 104)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: glutamate binding, glycine binding, molecular_function, protein binding, thienylcyclohexylpiperidine binding; CC: cell projection, centriole, centrosome, cilium, cytoplasm, cytoskeleton, spindle pole
Pathways:
UniProt: Q80V31
Entrez ID: 230967
|
Does Knockout of Pqbp1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Pqbp1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pqbp1 (polyglutamine binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, activation of innate immune response, alternative mRNA splicing, via spliceosome, cellular response to exogenous dsRNA, defense response to virus, immune system process, innate immune response, mRNA processing, neuron projection development, positive regulation of defense response to virus by host, positive regulation of non-motile cilium assembly, positive regulation of type I interferon production, regulation of RNA splicing, regulation of dendrite morphogenesis; MF: GTPase binding, double-stranded DNA binding, ribonucleoprotein complex binding; CC: centrosome, ciliary basal body, ciliary base, cilium, cytoplasm, cytoplasmic stress granule, cytosol, microtubule cytoskeleton, neuronal ribonucleoprotein granule, nuclear body, nuclear speck, nucleoplasm, nucleus, plasma membrane bounded cell projection
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q91VJ5
Entrez ID: 54633
|
Does Knockout of Rhobtb1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Rhobtb1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rhobtb1 (Rho-related BTB domain containing 1)
Type: protein-coding
Summary: Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; regulation of actin cytoskeleton organization; and regulation of cell shape. Predicted to be active in several cellular components, including cytoplasmic vesicle; cytoskeleton; and plasma membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and stomach. Orthologous to human RHOBTB1 (Rho related BTB domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: actin filament organization, cortical cytoskeleton organization, establishment or maintenance of cell polarity, regulation of actin cytoskeleton organization, regulation of cell shape, signal transduction, small GTPase-mediated signal transduction; MF: GTP binding, GTPase activity, nucleotide binding, protein binding, protein kinase binding; CC: cell projection, cytoplasmic vesicle, cytoskeleton, endosome membrane, plasma membrane
Pathways: RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB1 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9DAK3
Entrez ID: 69288
|
Does Knockout of Rasgrp3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Rasgrp3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rasgrp3 (RAS, guanyl releasing protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, immune response, small GTPase-mediated signal transduction; MF: GTPase activator activity, calcium ion binding, guanyl-nucleotide exchange factor activity, kinase binding, metal ion binding, small GTPase binding, zinc ion binding; CC: cytoplasm, cytosol, guanyl-nucleotide exchange factor complex, perinuclear region of cytoplasm, plasma membrane
Pathways: Activation of RAS in B cells, Adaptive Immune System, B cell receptor signaling pathway - Mus musculus (mouse), Downstream signaling events of B Cell Receptor (BCR), Immune System, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, Pathways in cancer - Mus musculus (mouse), RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by the B Cell Receptor (BCR)
UniProt: A0A3Q4EC09, Q6NZH9, A0A3Q4EG32
Entrez ID: 240168
|
Does Knockout of Krtap6-1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Krtap6-1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Krtap6-1 (keratin associated protein 6-1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, keratinization; MF: identical protein binding, molecular_function; CC: cellular_component, intermediate filament
Pathways: Developmental Biology, Keratinization
UniProt: O09048
Entrez ID: 16700
|
Does Knockout of Fkbp14 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Fkbp14
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fkbp14 (FK506 binding protein 14)
Type: protein-coding
Summary: Predicted to enable RNA polymerase II CTD heptapeptide repeat P3 isomerase activity; RNA polymerase II CTD heptapeptide repeat P6 isomerase activity; and calcium ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in endoplasmic reticulum lumen. Is expressed in cerebral cortex ventricular layer; cranium; jaw; and thoracic segment skeleton. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 2. Orthologous to human FKBP14 (FKBP prolyl isomerase 14). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: MF: calcium ion binding, isomerase activity, metal ion binding, peptidyl-prolyl cis-trans isomerase activity; CC: endoplasmic reticulum, endoplasmic reticulum lumen
Pathways:
UniProt: P59024
Entrez ID: 231997
|
Does Knockout of Dstn in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Dstn
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dstn (destrin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament depolymerization, actin filament fragmentation, actin filament severing, cell motility, positive regulation of actin filament depolymerization; MF: actin binding, actin filament binding; CC: actin cytoskeleton, cortical actin cytoskeleton, cytoplasm, glutamatergic synapse, postsynapse, presynapse
Pathways:
UniProt: Q9R0P5
Entrez ID: 56431
|
Does Knockout of Mrps18a in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Mrps18a
|
cell proliferation
|
Regulatory T cell
|
Gene: Mrps18a (mitochondrial ribosomal protein S18A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: small ribosomal subunit rRNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q99N85
Entrez ID: 68565
|
Does Knockout of Sel1l in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Sel1l
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sel1l (sel-1 suppressor of lin-12-like (C. elegans))
Type: protein-coding
Summary: Involved in ERAD pathway; protein secretion; and triglyceride metabolic process. Acts upstream of or within response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum. Predicted to be part of Derlin-1 retrotranslocation complex and Hrd1p ubiquitin ligase ERAD-L complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; liver; neural tube; pancreas; and spleen. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: ERAD pathway, Notch signaling pathway, protein secretion, protein transport, response to endoplasmic reticulum stress, retrograde protein transport, ER to cytosol, triglyceride metabolic process; CC: Derlin-1 retrotranslocation complex, Hrd1p ubiquitin ligase ERAD-L complex, Hrd1p ubiquitin ligase complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), Adaptive Immune System, Co-inhibition by PD-1, Hedgehog ligand biogenesis, Immune System, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Signal Transduction, Signaling by Hedgehog, Transport of small molecules
UniProt: Q9Z2G6
Entrez ID: 20338
|
Does Knockout of H2-M10.5 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
H2-M10.5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: H2-M10.5 (histocompatibility 2, M region locus 10.5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent, antigen processing and presentation of endogenous peptide antigen via MHC class Ib, antigen processing and presentation of peptide antigen via MHC class I, immune response, immune system process, positive regulation of T cell mediated cytotoxicity; MF: peptide antigen binding, signaling receptor binding; CC: MHC class I protein complex, external side of plasma membrane, extracellular space, lumenal side of endoplasmic reticulum membrane, membrane, phagocytic vesicle membrane
Pathways: Adaptive Immune System, Allograft rejection - Mus musculus (mouse), Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Mus musculus (mouse), Antigen processing-Cross presentation, Autoimmune thyroid disease - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Class I MHC mediated antigen processing & presentation, DAP12 interactions, ER-Phagosome pathway, Endocytosis - Mus musculus (mouse), Endosomal/Vacuolar pathway, Epstein-Barr virus infection - Mus musculus (mouse), Graft-versus-host disease - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Innate Immune System, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Neutrophil degranulation, Phagosome - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse)
UniProt: Q860W5, Q85ZW7
Entrez ID: 224761
|
Does Knockout of Eed in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Eed
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Eed (embryonic ectoderm development)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to leukemia inhibitory factor, chromatin organization, facultative heterochromatin formation, genomic imprinting, heterochromatin formation, negative regulation of transcription by RNA polymerase II, oligodendrocyte differentiation, positive regulation of amide metabolic process, positive regulation of lipid metabolic process, regulation of adaxial/abaxial pattern formation, regulation of membrane lipid metabolic process, spinal cord development, tumor necrosis factor-mediated signaling pathway; MF: chromatin binding, enzyme activator activity, identical protein binding, nucleosome binding, protein binding, sphingomyelin phosphodiesterase activator activity, transcription corepressor binding; CC: ESC/E(Z) complex, chromatin silencing complex, chromosome, cytosol, nucleoplasm, nucleus, plasma membrane, pronucleus, sex chromatin
Pathways: Adaptive Immune System, Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Chromatin modifying enzymes, Chromatin organization, Co-inhibition by PD-1, Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, Immune System, Negative Regulation of CDH1 Gene Transcription, Oxidative Stress Induced Senescence, PKMTs methylate histone lysines, PRC2 methylates histones and DNA, RNA Polymerase II Transcription, Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) expression, Regulation of PD-L1(CD274) transcription, Regulation of T cell activation by CD28 family, Transcriptional Regulation by E2F6
UniProt: Q921E6
Entrez ID: 13626
|
Does Knockout of Cyp2d40 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,683
|
Knockout
|
Cyp2d40
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cyp2d40 (cytochrome P450, family 2, subfamily d, polypeptide 40)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: anandamide 11,12 epoxidase activity, anandamide 14,15 epoxidase activity, anandamide 8,9 epoxidase activity, aromatase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrion
Pathways: Serotonergic synapse - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse)
UniProt: Q6P8N9
Entrez ID: 71754
|
Does Knockout of Ankrd61 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Ankrd61
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ankrd61 (ankyrin repeat domain 61)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, molecular_function; CC: nucleoplasm
Pathways:
UniProt: Q9CQM6
Entrez ID: 66729
|
Does Knockout of Shd in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Shd
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Shd (src homology 2 domain-containing transforming protein D)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: O88834
Entrez ID: 20420
|
Does Knockout of Med26 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Med26
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Med26 (mediator complex subunit 26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of gene expression, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: protein binding, transcription coregulator activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus
Pathways:
UniProt: Q7TN02
Entrez ID: 70625
|
Does Knockout of Sptlc3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Sptlc3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sptlc3 (serine palmitoyltransferase, long chain base subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide biosynthetic process, lipid metabolic process, sphingoid biosynthetic process, sphingolipid metabolic process, sphingosine biosynthetic process; MF: acyltransferase activity, pyridoxal phosphate binding, serine C-palmitoyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, serine palmitoyltransferase complex
Pathways: Metabolism, Metabolism of lipids, Sphingolipid de novo biosynthesis, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), ceramide biosynthesis
UniProt: Q8BG54
Entrez ID: 228677
|
Does Knockout of Acer2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Acer2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Acer2 (alkaline ceramidase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, cellular response to xenobiotic stimulus, ceramide catabolic process, ceramide metabolic process, lipid metabolic process, negative regulation of cell adhesion mediated by integrin, negative regulation of cell-matrix adhesion, positive regulation of cell population proliferation, regulation of apoptotic process, regulation of autophagy, regulation of protein glycosylation, response to retinoic acid, sphingolipid metabolic process, sphingosine biosynthetic process; MF: N-acylsphingosine amidohydrolase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, metal ion binding; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Metabolism, Metabolism of lipids, Sphingolipid catabolism, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), sphingosine and sphingosine-1-phosphate metabolism
UniProt: Q8VD53
Entrez ID: 230379
|
Does Knockout of Zfp105 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Zfp105
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Zfp105 (zinc finger protein 105)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: Q80WR2, G3X9I0, D3Z140
Entrez ID: 22646
|
Does Knockout of Slc23a2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Slc23a2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slc23a2 (solute carrier family 23 (nucleobase transporters), member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-ascorbic acid metabolic process, L-ascorbic acid transmembrane transport, blood circulation, cell adhesion, cellular response to ethanol, monoatomic ion transport, positive regulation of dendrite extension, response to oxidative stress, sodium ion transport, transmembrane transport; MF: L-ascorbate:sodium symporter activity, L-ascorbic acid transmembrane transporter activity, symporter activity, transmembrane transporter activity; CC: apical plasma membrane, basal plasma membrane, basolateral plasma membrane, cytoplasm, membrane, plasma membrane
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Vitamin C (ascorbate) metabolism
UniProt: Q9EPR4
Entrez ID: 54338
|
Does Knockout of Sftpc in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Sftpc
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Sftpc (surfactant associated protein C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: alveolar lamellar body, cytoplasm, extracellular region, extracellular space, multivesicular body
Pathways:
UniProt: Q6P8P8
Entrez ID: 20389
|
Does Knockout of Gzmn in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Gzmn
|
cell cycle progression
|
breast epithelium
|
Gene: Gzmn (granzyme N)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein maturation, proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: cytolytic granule, cytoplasm, extracellular space
Pathways:
UniProt: Q920S1, Q76HN3
Entrez ID: 245839
|
Does Knockout of G6pd2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
G6pd2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: G6pd2 (glucose-6-phosphate dehydrogenase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NADP+ metabolic process, NADPH regeneration, cellular response to oxidative stress, cholesterol biosynthetic process, erythrocyte maturation, glucose 6-phosphate metabolic process, glucose metabolic process, glutathione metabolic process, negative regulation of cell growth involved in cardiac muscle cell development, negative regulation of reactive oxygen species metabolic process, pentose biosynthetic process, pentose-phosphate shunt, pentose-phosphate shunt, oxidative branch, positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, regulation of neuron apoptotic process, response to ethanol, ribose phosphate biosynthetic process; MF: D-glucose binding, NADP binding, carbohydrate binding, glucose-6-phosphate dehydrogenase activity, identical protein binding, oxidoreductase activity, oxidoreductase activity, acting on CH-OH group of donors, protein homodimerization activity; CC: centriolar satellite, cytoplasm, cytoplasmic side of plasma membrane, cytosol, membrane
Pathways: Central carbon metabolism in cancer - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Glutathione metabolism - Mus musculus (mouse), Pentose phosphate pathway - Mus musculus (mouse), formaldehyde oxidation I, pentose phosphate pathway, pentose phosphate pathway (oxidative branch)
UniProt: P97324
Entrez ID: 14380
|
Does Knockout of 4930510E17Rik in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
4930510E17Rik
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: 4930510E17Rik (RIKEN cDNA 4930510E17 gene)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Fundc1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Fundc1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Fundc1 (FUN14 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, autophagy of mitochondrion, mitochondrial fusion, mitophagy, response to hypoxia; CC: membrane, mitochondrial outer membrane, mitochondrion
Pathways: Autophagy, Macroautophagy, Mitophagy, Mitophagy - animal - Mus musculus (mouse), Receptor Mediated Mitophagy, Selective autophagy
UniProt: Q9DB70
Entrez ID: 72018
|
Does Knockout of Kctd2 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,177
|
Knockout
|
Kctd2
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Kctd2 (potassium channel tetramerisation domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein homooligomerization; MF: cullin family protein binding, protein-containing complex binding; CC: Cul3-RING ubiquitin ligase complex, cytoplasm
Pathways:
UniProt: A2A9V9, Q4VBE7, F6SH71
Entrez ID: 70382
|
Does Knockout of Scgb2b7 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Scgb2b7
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Scgb2b7 (secretoglobin, family 2B, member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, extracellular region, extracellular space
Pathways:
UniProt: D3YYY1
Entrez ID: 100043836
|
Does Knockout of Spata7 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Spata7
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Spata7 (spermatogenesis associated 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule cytoskeleton organization, photoreceptor cell maintenance, protein localization to photoreceptor connecting cilium, protein localization to photoreceptor outer segment, visual perception; CC: axoneme, cell projection, ciliary basal body, cytoplasm, cytoskeleton, microtubule cytoskeleton, photoreceptor connecting cilium, photoreceptor distal connecting cilium, photoreceptor outer segment, rod photoreceptor outer segment
Pathways:
UniProt: Q80VP2
Entrez ID: 104871
|
Does Knockout of Iqgap1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Iqgap1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Iqgap1 (IQ motif containing GTPase activating protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, caveola assembly, cell migration, cellular response to calcium ion, cellular response to epidermal growth factor stimulus, cellular response to fibroblast growth factor stimulus, cellular response to platelet-derived growth factor stimulus, epidermal growth factor receptor signaling pathway, fibroblast growth factor receptor signaling pathway, fibroblast migration, mitotic actomyosin contractile ring assembly actin filament organization, negative regulation of dephosphorylation, neuron projection extension, platelet-derived growth factor receptor signaling pathway, podocyte development, positive regulation of MAPK cascade, positive regulation of dendrite development, positive regulation of focal adhesion assembly, positive regulation of protein localization, positive regulation of vascular associated smooth muscle cell migration, regulation of cytokine production, regulation of mitotic cell cycle, regulation of postsynapse assembly, response to angiotensin; MF: GTPase activator activity, MAP-kinase scaffold activity, S100 protein binding, actin filament binding, calcium ion binding, calmodulin binding, mitogen-activated protein kinase binding, molecular adaptor activity, phosphatidylinositol-3,4,5-trisphosphate binding, protein binding, protein domain specific binding, protein kinase binding, protein phosphatase binding, protein serine/threonine kinase activator activity, protein-containing complex binding, small GTPase binding; CC: actin cytoskeleton, apical plasma membrane, axon, basolateral plasma membrane, cell cortex, cell leading edge, cell-cell junction, cortical actin cytoskeleton, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic side of plasma membrane, focal adhesion, growth cone, lateral plasma membrane, membrane, microtubule, microtubule cytoskeleton, midbody, neuron projection, nucleus, plasma membrane, plasma membrane bounded cell projection, postsynapse, protein-containing complex, ribonucleoprotein complex, ruffle, slit diaphragm
Pathways: Adherens junction - Mus musculus (mouse), Cell-Cell communication, Immune System, Innate Immune System, MAP2K and MAPK activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Nephrin family interactions, Neutrophil degranulation, Proteoglycans in cancer - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RAF/MAP kinase cascade, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases activate IQGAPs, RHOA GTPase cycle, RHOC GTPase cycle, RHOQ GTPase cycle, RHOU GTPase cycle, RHOV GTPase cycle, Regulation of actin cytoskeleton - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9JKF1
Entrez ID: 29875
|
Does Knockout of Ifngr2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,276
|
Knockout
|
Ifngr2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ifngr2 (interferon gamma receptor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytokine-mediated signaling pathway, defense response to virus, microglial cell activation, positive regulation of glutamate receptor signaling pathway, type II interferon-mediated signaling pathway, type III interferon-mediated signaling pathway; MF: cytokine receptor activity, type II interferon receptor activity; CC: membrane, plasma membrane
Pathways: Chagas disease - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), IFNG signaling activates MAPKs, Immune System, Inflammatory bowel disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Interferon Signaling, Interferon gamma signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Regulation of IFNG signaling, Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: D6RIP6, Q63953
Entrez ID: 15980
|
Does Knockout of Vmn2r45 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Vmn2r45
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Vmn2r45 (vomeronasal 2, receptor 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: L7N2B5
Entrez ID: 100042810
|
Does Knockout of BC016579 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
BC016579
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: BC016579 (cDNA sequence, BC016579)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways:
UniProt: Q8C5C9
Entrez ID: 212998
|
Does Knockout of Ccnb1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Ccnb1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ccnb1 (cyclin B1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, cell division, cellular response to fatty acid, cellular response to hypoxia, cellular response to iron(III) ion, digestive tract development, in utero embryonic development, mitotic cell cycle phase transition, mitotic metaphase chromosome alignment, mitotic spindle organization, negative regulation of gene expression, oocyte maturation, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of attachment of spindle microtubules to kinetochore, positive regulation of cardiac muscle cell proliferation, positive regulation of cell cycle, positive regulation of fibroblast proliferation, positive regulation of mRNA 3'-end processing, positive regulation of mitochondrial ATP synthesis coupled electron transport, positive regulation of mitotic cell cycle, protein-containing complex assembly, regulation of chromosome condensation, regulation of mitotic cell cycle spindle assembly checkpoint, response to DDT, response to mechanical stimulus, response to toxic substance, response to xenobiotic stimulus, spermatogenesis, tissue regeneration, ventricular cardiac muscle cell development; MF: cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase regulator activity, patched binding, protein binding, protein kinase binding, protein-containing complex binding, ubiquitin-like protein ligase binding; CC: centrosome, cyclin B1-CDK1 complex, cytoplasm, cytoskeleton, cytosol, membrane, microtubule organizing center, mitochondrial matrix, nucleus, outer kinetochore, spindle pole
Pathways: APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NIMA Kinases NEK9, NEK6, NEK7, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, Condensation of Prophase Chromosomes, Cyclin A/B1/B2 associated events during G2/M transition, Depolymerization of the Nuclear Lamina, FoxO signaling pathway - Mus musculus (mouse), G2/M Checkpoints, G2/M DNA damage checkpoint, G2/M DNA replication checkpoint, G2/M Transition, Gene expression (Transcription), Generic Transcription Pathway, Human immunodeficiency virus 1 infection - Mus musculus (mouse), Initiation of Nuclear Envelope (NE) Reformation, M Phase, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Oocyte meiosis - Mus musculus (mouse), Phosphorylation of Emi1, Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of PLK1 Activity at G2/M Transition, Regulation of mitotic cell cycle, Resolution of Sister Chromatid Cohesion, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional Regulation by TP53, Transcriptional regulation by RUNX2, p53 signaling pathway - Mus musculus (mouse)
UniProt: P24860
Entrez ID: 268697
|
Does Knockout of Dcp1b in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Dcp1b
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Dcp1b (decapping mRNA 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to interleukin-17, deadenylation-dependent decapping of nuclear-transcribed mRNA, deadenylation-independent decapping of nuclear-transcribed mRNA, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, protein localization to P-body, protein localization to nucleus; MF: 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity, enzyme activator activity, hydrolase activity, mRNA binding, protein binding; CC: P-body, cytoplasm, cytosol, nucleus
Pathways: RNA degradation - Mus musculus (mouse)
UniProt: Q3U564
Entrez ID: 319618
|
Does Knockout of Col3a1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Col3a1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Col3a1 (collagen, type III, alpha 1)
Type: protein-coding
Summary: This gene encodes the alpha-1 subunit of the fibril-forming type III collagen found in bone, cartilage, dentin, tendon, bone marrow stroma and other connective tissue. The encoded protein forms homotrimeric type III procollagen that undergoes proteolytic processing during fibril formation. A majority of mice lacking the encoded protein die within two days of birth but about 5% of the animals survive to adulthood. The surviving mice exhibit severe cortical malformation and experience significantly shorter lifespan. The mutant mouse named 'tight skin 2' exhibiting systemic sclerosis phenotype was found to harbor a missense point mutation in this gene. A pseudogene of this gene has been defined on chromosome 8. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: aorta development, aorta smooth muscle tissue morphogenesis, basement membrane organization, blood vessel development, cartilage development, cell-matrix adhesion, cellular response to amino acid stimulus, cerebral cortex development, chondrocyte differentiation, collagen fibril organization, digestive tract development, elastic fiber assembly, endochondral bone morphogenesis, extracellular matrix organization, fibroblast proliferation, gene expression, heart development, in utero embryonic development, integrin-mediated signaling pathway, layer formation in cerebral cortex, limb joint morphogenesis, lung development, multicellular organism growth, negative regulation of immune response, negative regulation of neuron migration, neuron migration, positive regulation of Rho protein signal transduction, response to angiotensin, response to cytokine, response to radiation, skeletal system development, skin development, supramolecular fiber organization, tissue homeostasis, transforming growth factor beta receptor signaling pathway, transforming growth factor beta1 production, wound healing; MF: SMAD binding, extracellular matrix structural constituent, extracellular matrix structural constituent conferring tensile strength, integrin binding, metal ion binding, platelet-derived growth factor binding, protease binding; CC: collagen trimer, collagen type III trimer, extracellular matrix, extracellular region, extracellular space
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Adaptive Immune System, Amoebiasis - Mus musculus (mouse), Assembly of collagen fibrils and other multimeric structures, Axon guidance, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen degradation, Collagen formation, Degradation of the extracellular matrix, Developmental Biology, Diabetic cardiomyopathy - Mus musculus (mouse), ECM proteoglycans, Extracellular matrix organization, Fibronectin matrix formation, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Integrin cell surface interactions, MET activates PTK2 signaling, MET promotes cell motility, NCAM signaling for neurite out-growth, NCAM1 interactions, Nervous system development, Non-integrin membrane-ECM interactions, Platelet activation - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by MET, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases
UniProt: P08121
Entrez ID: 12825
|
Does Knockout of Foxa2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Foxa2
|
cell cycle progression
|
breast epithelium
|
Gene: Foxa2 (forkhead box A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, adult locomotory behavior, anatomical structure formation involved in morphogenesis, anatomical structure morphogenesis, anterior/posterior pattern specification, cell development, cell differentiation, cell differentiation in hindbrain, cell fate specification, cellular response to cadmium ion, chromatin organization, connective tissue development, dopaminergic neuron differentiation, dorsal/ventral neural tube patterning, dorsal/ventral pattern formation, ectoderm formation, endocrine pancreas development, epithelial tube branching involved in lung morphogenesis, gene expression, glucose homeostasis, glucose mediated signaling pathway, in utero embryonic development, lung development, lung epithelial cell differentiation, mesendoderm development, negative regulation of epithelial to mesenchymal transition, negative regulation of neuron differentiation, negative regulation of transcription by RNA polymerase II, neuron differentiation, neuron fate specification, pattern specification process, positive regulation of DNA-templated transcription, positive regulation of dopaminergic neuron differentiation, positive regulation of embryonic development, positive regulation of gastrulation, positive regulation of neuron differentiation, positive regulation of smoothened signaling pathway, positive regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase III, primitive streak formation, regulation of DNA-templated transcription, regulation of blood coagulation, regulation of gene expression, regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of lipid metabolic process, regulation of steroid metabolic process, regulation of transcription by RNA polymerase II, response to interleukin-6, signal transduction involved in regulation of gene expression, somite rostral/caudal axis specification; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase II-specific DNA-binding transcription factor binding, SMAD binding, chromatin binding, double-stranded DNA binding, kinase binding, nucleic acid binding, protein binding, protein domain specific binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription corepressor activity; CC: cell junction, cytoplasm, nucleoplasm, nucleus, transcription regulator complex
Pathways: Longevity regulating pathway - multiple species - Mus musculus (mouse), Maturity onset diabetes of the young - Mus musculus (mouse)
UniProt: P35583
Entrez ID: 15376
|
Does Knockout of Nxph4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Nxph4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nxph4 (neurexophilin 4)
Type: protein-coding
Summary: Predicted to enable signaling receptor binding activity. Involved in modulation of chemical synaptic transmission. Is active in GABA-ergic synapse. Is expressed in brain and spinal cord lateral wall. Orthologous to human NXPH4 (neurexophilin 4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, modulation of chemical synaptic transmission; MF: signaling receptor binding; CC: GABA-ergic synapse, cellular_component, extracellular region, synapse
Pathways:
UniProt: Q8BTD1, G3X9N5
Entrez ID: 104080
|
Does Knockout of Kif14 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Kif14
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Kif14 (kinesin family member 14)
Type: protein-coding
Summary: Enables several functions, including ATP binding activity; ATP hydrolysis activity; and plus-end-directed microtubule motor activity. Involved in several processes, including brain development; negative regulation of neuron apoptotic process; and regulation of myelination. Predicted to be located in several cellular components, including Flemming body; cytosol; and spindle midzone. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Predicted to colocalize with plasma membrane. Is expressed in heart and retina. Human ortholog(s) of this gene implicated in Meckel syndrome and primary autosomal recessive microcephaly 20. Orthologous to human KIF14 (kinesin family member 14). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, activation of protein kinase activity, cell division, cell proliferation in forebrain, cerebellar Purkinje cell layer structural organization, cerebellar cortex development, cerebellar granular layer structural organization, cerebral cortex development, establishment of protein localization, hippocampus development, microtubule depolymerization, microtubule-based movement, mitotic metaphase chromosome alignment, negative regulation of apoptotic process, negative regulation of integrin activation, negative regulation of neuron apoptotic process, olfactory bulb development, positive regulation of cell population proliferation, positive regulation of cytokinesis, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of G1/S transition of mitotic cell cycle, regulation of G2/M transition of mitotic cell cycle, regulation of Rap protein signal transduction, regulation of cell adhesion, regulation of cell growth, regulation of cell maturation, regulation of cell migration, regulation of myelination, regulation of neuron apoptotic process, substrate adhesion-dependent cell spreading; MF: ATP binding, ATP hydrolysis activity, PDZ domain binding, microtubule binding, microtubule motor activity, nucleotide binding, plus-end-directed microtubule motor activity, protein kinase binding, tubulin binding; CC: Flemming body, cytoplasm, cytoskeleton, cytosol, kinesin complex, membrane, microtubule, midbody, nucleus, plasma membrane, spindle, spindle midzone
Pathways: RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases activate CIT, RND1 GTPase cycle, RND2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: L0N7N1
Entrez ID: 381293
|
Does Knockout of Vrk1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Vrk1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Vrk1 (vaccinia related kinase 1)
Type: protein-coding
Summary: Enables protein serine/threonine kinase activity. Involved in regulation of neuron migration. Acts upstream of or within protein autophosphorylation. Located in nucleus. Is expressed in several structures, including dorsal mesogastrium; hemolymphoid system; liver; metanephros; and yolk sac. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 10 and pontocerebellar hypoplasia type 1A. Orthologous to human VRK1 (VRK serine/threonine kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Cajal body organization, DNA damage response, Golgi disassembly, cell division, chromatin remodeling, neuron projection development, positive regulation of protein localization to chromatin, positive regulation of transcription by RNA polymerase II, regulation of neuron migration, signal transduction; MF: ATP binding, histone H2AX kinase activity, histone H3S10 kinase activity, histone H3T3 kinase activity, histone binding, kinase activity, nucleosomal DNA binding, nucleotide binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Cajal body, Golgi stack, chromatin, cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Initiation of Nuclear Envelope (NE) Reformation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown
UniProt: Q80X41
Entrez ID: 22367
|
Does Knockout of Rpl37a in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 685
|
Knockout
|
Rpl37a
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Rpl37a (ribosomal protein L37a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: large ribosomal subunit rRNA binding, metal ion binding, structural constituent of ribosome, zinc ion binding; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P61514
Entrez ID: 19981
|
Does Knockout of Rreb1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Rreb1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rreb1 (ras responsive element binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of brown fat cell differentiation, positive regulation of developmental process, positive regulation of epithelial cell migration, positive regulation of lamellipodium morphogenesis, positive regulation of mammary gland epithelial cell proliferation, positive regulation of substrate adhesion-dependent cell spreading, positive regulation of transcription by RNA polymerase II, positive regulation of wound healing, spreading of epidermal cells, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: fibrillar center, nuclear speck, nucleus
Pathways:
UniProt: Q3UH06
Entrez ID: 68750
|
Does Knockout of Ppp6r1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Ppp6r1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ppp6r1 (protein phosphatase 6, regulatory subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: protein phosphatase binding, protein phosphatase regulator activity, small GTPase binding; CC: cytoplasm, cytosol, lamellipodium, nucleus
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q7TSI3
Entrez ID: 243819
|
Does Knockout of Cxcl1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Cxcl1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Cxcl1 (C-X-C motif chemokine ligand 1)
Type: protein-coding
Summary: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013].
Gene Ontology: BP: cell chemotaxis, cellular response to interleukin-17, chemotaxis, defense response, immune response, inflammatory response, neutrophil chemotaxis, positive regulation of cytosolic calcium ion concentration, positive regulation of hematopoietic stem cell proliferation, positive regulation of neutrophil mediated killing of fungus, positive regulation of potassium ion transport, positive regulation of sodium ion transport, positive regulation of superoxide anion generation, signal transduction; MF: chemokine activity, cytokine activity, growth factor activity; CC: extracellular region, extracellular space
Pathways: Alcoholic liver disease - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Chemokine receptors bind chemokines, Chemokine signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Mus musculus (mouse), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, IL-17 signaling pathway - Mus musculus (mouse), Immune System, Innate Immune System, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Legionellosis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Neutrophil degranulation, Peptide ligand-binding receptors, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, TNF signaling pathway - Mus musculus (mouse), Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: P12850
Entrez ID: 14825
|
Does Knockout of Zfp775 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Zfp775
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Zfp775 (zinc finger protein 775)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q8BI73
Entrez ID: 243372
|
Does Knockout of Sec24b in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Sec24b
|
phagocytosis
|
macrophage
|
Gene: Sec24b (SEC24 homolog B, COPII coat complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPII-coated vesicle cargo loading, aorta morphogenesis, auditory receptor cell morphogenesis, auditory receptor cell stereocilium organization, circulatory system development, cochlear nucleus development, coronary artery morphogenesis, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, lung lobe morphogenesis, lung morphogenesis, neural tube closure, outflow tract morphogenesis, protein transport, pulmonary artery morphogenesis, regulation of cargo loading into COPII-coated vesicle, regulation of establishment of planar polarity involved in neural tube closure, vesicle-mediated transport; MF: SNARE binding, metal ion binding, protein binding, zinc ion binding; CC: COPII vesicle coat, COPII-coated ER to Golgi transport vesicle, ER to Golgi transport vesicle membrane, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum exit site, endoplasmic reticulum membrane, membrane
Pathways: Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Asparagine N-linked glycosylation, COPII-mediated vesicle transport, Cargo concentration in the ER, Class I MHC mediated antigen processing & presentation, ER to Golgi Anterograde Transport, Immune System, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: F6YIN5, Q80ZX0, F6VJC5
Entrez ID: 99683
|
Does Knockout of Nlrc4 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Nlrc4
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Nlrc4 (NLR family, CARD domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of innate immune response, apoptotic process, defense response to bacterium, detection of bacterium, immune system process, inflammatory response, innate immune response, positive regulation of apoptotic process, positive regulation of interleukin-1 beta production, positive regulation of protein processing, protein homooligomerization, pyroptotic inflammatory response, regulation of apoptotic process; MF: ATP binding, caspase binding, endopeptidase activator activity, identical protein binding, nucleotide binding, protein binding, protein homodimerization activity; CC: IPAF inflammasome complex, canonical inflammasome complex, cytoplasm, cytosol, plasma membrane
Pathways: Legionellosis - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse)
UniProt: Q3UP24
Entrez ID: 268973
|
Does Knockout of Rae1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Rae1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Rae1 (ribonucleic acid export 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, cell division, nucleocytoplasmic transport, regulation of mitotic spindle organization, transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; MF: RNA binding, ubiquitin binding; CC: cytoplasm, cytoskeleton, fibrillar center, mitotic spindle pole, nuclear envelope, nuclear pore, nucleoplasm, nucleus, spindle pole
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Influenza A - Mus musculus (mouse), Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q8C570
Entrez ID: 66679
|
Does Knockout of Syde2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Syde2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Syde2 (synapse defective 1, Rho GTPase, homolog 2 (C. elegans))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, regulation of Ras protein signal transduction
Pathways: RAC1 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8BKW6, E9PUP1, A0A1D5RLX6, A0A0G2JEY9
Entrez ID: 214804
|
Does Knockout of Grtp1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Grtp1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Grtp1 (GH regulated TBC protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: GTPase activator activity; CC: cytoplasm, plasma membrane
Pathways:
UniProt: Q9D3N8
Entrez ID: 66790
|
Does Knockout of Chrna7 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Chrna7
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Chrna7 (cholinergic receptor, nicotinic, alpha polypeptide 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, T cell activation, acetylcholine receptor signaling pathway, associative learning, behavioral response to ethanol, behavioral response to nicotine, calcium ion transport, chemical synaptic transmission, dendrite arborization, dendritic spine organization, endocytosis, establishment of localization in cell, excitatory postsynaptic potential, flagellated sperm motility, generation of ovulation cycle rhythm, learning or memory, ligand-gated ion channel signaling pathway, memory, modulation of chemical synaptic transmission, modulation of excitatory postsynaptic potential, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of ERK1 and ERK2 cascade, negative regulation of canonical NF-kappaB signal transduction, negative regulation of cytokine production involved in inflammatory response, negative regulation of inflammatory response, negative regulation of interleukin-1 beta production, negative regulation of interleukin-6 production, negative regulation of intracellular signal transduction, negative regulation of tumor necrosis factor production, neuronal action potential, ovulation cycle, positive regulation of ERK1 and ERK2 cascade, positive regulation of amyloid-beta formation, positive regulation of excitatory postsynaptic potential, positive regulation of gene expression, positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure, positive regulation of long-term synaptic potentiation, positive regulation of protein metabolic process, presynaptic modulation of chemical synaptic transmission, regulation of amyloid fibril formation, regulation of inflammatory response, regulation of membrane potential, regulation of norepinephrine secretion, regulation of postsynaptic membrane potential, regulation of response to drug, regulation of synapse structural plasticity, regulation of synaptic transmission, dopaminergic, response to acetylcholine, response to amyloid-beta, response to cold, response to ethanol, response to food, response to nicotine, sensory processing, synapse organization, synaptic transmission involved in micturition, synaptic transmission, cholinergic; MF: ATPase binding, acetylcholine binding, acetylcholine receptor activity, acetylcholine-gated monoatomic cation-selective channel activity, adenylate cyclase binding, amyloid-beta binding, chloride channel regulator activity, extracellular ligand-gated monoatomic ion channel activity, metal ion binding, monoatomic ion channel activity, protein binding, protein homodimerization activity, protein kinase binding, scaffold protein binding, toxic substance binding, transmembrane signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: acetylcholine-gated channel complex, apical plasma membrane, asymmetric synapse, axolemma, axon, cation channel complex, cholinergic synapse, dendrite, dendritic shaft, dendritic spine, external side of plasma membrane, glycinergic synapse, growth cone, membrane, neuron projection, neuronal cell body, neurotransmitter receptor complex, plasma membrane, plasma membrane raft, postsynaptic membrane, postsynaptic specialization membrane, presynapse, presynaptic membrane, spine apparatus membrane, synapse
Pathways: Acetylcholine binding and downstream events, Alzheimer disease - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Highly calcium permeable postsynaptic nicotinic acetylcholine receptors, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nicotine addiction - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Postsynaptic nicotinic acetylcholine receptors, Transmission across Chemical Synapses
UniProt: P49582
Entrez ID: 11441
|
Does Knockout of Pet100 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Pet100
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pet100 (PET100 homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial cytochrome c oxidase assembly; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: P0DJE0
Entrez ID: 100503890
|
Does Knockout of Dydc2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Dydc2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Dydc2 (DPY30 domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D3X8
Entrez ID: 71200
|
Does Knockout of Adgra3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Adgra3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Adgra3 (adhesion G protein-coupled receptor A3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity, transmembrane signaling receptor activity; CC: external side of plasma membrane, membrane, plasma membrane
Pathways:
UniProt: Q7TT36
Entrez ID: 70693
|
Does Knockout of Atl3 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Atl3
|
cell cycle progression
|
breast epithelium
|
Gene: Atl3 (atlastin GTPase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, cellular response to type II interferon, endoplasmic reticulum membrane fusion, endoplasmic reticulum organization, endoplasmic reticulum tubular network membrane organization, protein homooligomerization; MF: GTP binding, GTPase activity, GTPase-dependent fusogenic activity, hydrolase activity, identical protein binding, metal ion binding, nucleotide binding, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum tubular network, endoplasmic reticulum tubular network membrane, membrane
Pathways:
UniProt: Q91YH5
Entrez ID: 109168
|
Does Knockout of Gm3409 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Gm3409
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Gm3409 (predicted gene 3409)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: guanyl-nucleotide exchange factor activity, molecular_function
Pathways:
UniProt: A0A0G2JE67, L7N464, D3YYA7
Entrez ID: 100041566
|
Does Knockout of Litaf in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Litaf
|
cell proliferation
|
Regulatory T cell
|
Gene: Litaf (LPS-induced TN factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to lipopolysaccharide, negative regulation of non-canonical NF-kappaB signal transduction, positive regulation of canonical NF-kappaB signal transduction, positive regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of macrophage cytokine production, response to lipopolysaccharide; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, WW domain binding, identical protein binding, metal ion binding, protein binding, zinc ion binding; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic side of early endosome membrane, cytoplasmic side of late endosome membrane, cytoplasmic side of lysosomal membrane, cytoplasmic side of plasma membrane, early endosome membrane, endosome, endosome membrane, late endosome membrane, lysosomal membrane, lysosome, membrane, nucleoplasm, nucleus, plasma membrane
Pathways: Lysosome - Mus musculus (mouse)
UniProt: Q9JLJ0
Entrez ID: 56722
|
Does Knockout of Ttf2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Ttf2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ttf2 (transcription termination factor, RNA polymerase II)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, DNA-templated transcription termination, RNA splicing, biological_process, mRNA processing; MF: ATP binding, ATP-dependent activity, acting on DNA, DNA binding, helicase activity, hydrolase activity, metal ion binding, molecular_function, nucleotide binding, zinc ion binding; CC: cytoplasm, cytosol, nucleus, spliceosomal complex
Pathways: Thyroid hormone synthesis - Mus musculus (mouse)
UniProt: Q5NC05
Entrez ID: 74044
|
Does Knockout of Saa4 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Saa4
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Saa4 (serum amyloid A 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: extracellular region, high-density lipoprotein particle
Pathways:
UniProt: P31532
Entrez ID: 20211
|
Does Knockout of Pcdh17 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Pcdh17
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pcdh17 (protocadherin 17)
Type: protein-coding
Summary: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: adult behavior, cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of synaptic transmission, presynaptic active zone assembly, regulation of synaptic vesicle clustering, synaptic membrane adhesion; MF: calcium ion binding, cell adhesion molecule binding; CC: GABA-ergic synapse, glutamatergic synapse, membrane, plasma membrane, postsynaptic membrane, presynaptic membrane
Pathways:
UniProt: Q5HZI5, Q3UTP0, E9PXF0
Entrez ID: 219228
|
Does Knockout of Trip10 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Trip10
|
phagocytosis
|
macrophage
|
Gene: Trip10 (thyroid hormone receptor interactor 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endocytosis, epithelial to mesenchymal transition, negative regulation of cardiac muscle cell apoptotic process, positive regulation of cell growth involved in cardiac muscle cell development, signal transduction; MF: identical protein binding, lipid binding, protein binding; CC: Golgi apparatus, cell cortex, cell projection, cytoplasm, cytoskeleton, lysosome, membrane, microtubule, nucleoplasm, phagocytic cup, plasma membrane
Pathways: Clathrin-mediated endocytosis, Insulin signaling pathway - Mus musculus (mouse), Membrane Trafficking, RHO GTPase cycle, RHOQ GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport
UniProt: Q8CJ53
Entrez ID: 106628
|
Does Knockout of Cstl1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Cstl1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Cstl1 (cystatin-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled opioid receptor signaling pathway, signaling receptor ligand precursor processing, transmission of nerve impulse; MF: cysteine-type endopeptidase inhibitor activity, cysteine-type peptidase activity, peptidase inhibitor activity
Pathways:
UniProt: Q80Y72
Entrez ID: 228756
|
Does Knockout of Vps9d1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Vps9d1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Vps9d1 (VPS9 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, vesicle-mediated transport; MF: guanyl-nucleotide exchange factor activity, identical protein binding, molecular_function, small GTPase binding; CC: cytosol, endocytic vesicle
Pathways:
UniProt: Q8C190
Entrez ID: 72325
|
Does Knockout of Alg6 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Alg6
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Alg6 (ALG6 alpha-1,3-glucosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation, protein glycosylation; MF: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity, glucosyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, N-Glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification, dolichyl-diphosphooligosaccharide biosynthesis
UniProt: Q3TAE8
Entrez ID: 320438
|
Does Knockout of Wfdc12 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Wfdc12
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Wfdc12 (WAP four-disulfide core domain 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, defense response to bacterium, innate immune response; MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q9JHY3
Entrez ID: 192200
|
Does Knockout of Gps1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Gps1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gps1 (G protein pathway suppressor 1)
Type: protein-coding
Summary: Predicted to be involved in protein deneddylation. Part of COP9 signalosome. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; hemolymphoid system gland; and retina. Orthologous to human GPS1 (G protein pathway suppressor 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: COP9 signalosome, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: A0A140LJB7, Q3MIA8, B1ATU4, G3UXW9, D6RCV3
Entrez ID: 209318
|
Does Knockout of Kcnc1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Kcnc1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Kcnc1 (potassium voltage gated channel, Shaw-related subfamily, member 1)
Type: protein-coding
Summary: Enables kinesin binding activity and transmembrane transporter binding activity. Predicted to be involved in several processes, including positive regulation of potassium ion transmembrane transport; potassium ion transmembrane transport; and protein tetramerization. Located in axolemma; dendrite membrane; and neuronal cell body membrane. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; hindlimb muscle; and liver. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 7. Orthologous to human KCNC1 (potassium voltage-gated channel subfamily C member 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: action potential, cellular response to xenobiotic stimulus, cerebellum development, corpus callosum development, globus pallidus development, monoatomic ion transmembrane transport, monoatomic ion transport, optic nerve development, positive regulation of monoatomic ion transmembrane transport, positive regulation of potassium ion transmembrane transport, potassium ion transmembrane transport, potassium ion transport, protein homooligomerization, protein tetramerization, regulation of monoatomic ion transmembrane transport, regulation of potassium ion transmembrane transport, regulation of presynaptic membrane potential, response to amine, response to auditory stimulus, response to fibroblast growth factor, response to light intensity, response to nerve growth factor, response to potassium ion, response to toxic substance, transmembrane transport; MF: delayed rectifier potassium channel activity, kinesin binding, metal ion binding, monoatomic ion channel activity, potassium channel activity, protein binding, transmembrane transporter binding, voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, voltage-gated potassium channel activity; CC: axolemma, axon, axon terminus, calyx of Held, cell projection, cell surface, dendrite, dendrite membrane, membrane, monoatomic ion channel complex, neuron projection membrane, neuronal cell body, neuronal cell body membrane, plasma membrane, postsynaptic membrane, presynaptic membrane, synapse, voltage-gated potassium channel complex
Pathways: Neuronal System, Potassium Channels, Voltage gated Potassium channels
UniProt: P15388
Entrez ID: 16502
|
Does Knockout of Rimbp2 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Rimbp2
|
response to virus
|
Microglial Cell Line
|
Gene: Rimbp2 (RIMS binding protein 2)
Type: protein-coding
Summary: Enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. A structural constituent of presynaptic active zone. Involved in regulation of calcium-dependent activation of synaptic vesicle fusion and regulation of presynaptic membrane potential. Is active in calyx of Held; glutamatergic synapse; and presynaptic active zone cytoplasmic component. Orthologous to human RIMBP2 (RIMS binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: maintenance of presynaptic active zone structure, neuromuscular synaptic transmission, regulation of calcium-dependent activation of synaptic vesicle fusion, regulation of presynaptic cytosolic calcium ion concentration, regulation of presynaptic membrane potential; MF: protein-macromolecule adaptor activity, structural constituent of presynaptic active zone, voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels, voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; CC: calyx of Held, glutamatergic synapse, membrane, plasma membrane, presynaptic active zone cytoplasmic component, synapse, synaptic ribbon
Pathways:
UniProt: Q80U40
Entrez ID: 231760
|
Does Knockout of Ppcs in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,170
|
Knockout
|
Ppcs
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ppcs (phosphopantothenoylcysteine synthetase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetyl-CoA biosynthetic process, coenzyme A biosynthetic process, heart process; MF: ATP binding, identical protein binding, ligase activity, nucleotide binding, phosphopantothenate--cysteine ligase activity, protein homodimerization activity; CC: cytoplasm, nucleus
Pathways: Coenzyme A biosynthesis, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Pantothenate and CoA biosynthesis - Mus musculus (mouse), Vitamin B5 (pantothenate) metabolism, coenzyme A biosynthesis
UniProt: Q8VDG5
Entrez ID: 106564
|
Does Knockout of Slc1a7 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Slc1a7
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Slc1a7 (solute carrier family 1 (glutamate transporter), member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-glutamate transmembrane transport, chloride transmembrane transport, excitatory postsynaptic potential, monoatomic anion transmembrane transport, neurotransmitter uptake, neutral amino acid transport; MF: L-glutamate transmembrane transporter activity, extracellularly glutamate-gated chloride channel activity, glutamate:sodium symporter activity, monoatomic anion transmembrane transporter activity, neutral L-amino acid transmembrane transporter activity, symporter activity; CC: axon terminus, glutamatergic synapse, membrane, photoreceptor cell terminal bouton, plasma membrane, postsynaptic membrane, presynaptic membrane, synapse, synaptic membrane
Pathways: Glutamate Neurotransmitter Release Cycle, Glutamatergic synapse - Mus musculus (mouse), Neuronal System, Neurotransmitter release cycle, SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Synaptic vesicle cycle - Mus musculus (mouse), Transmission across Chemical Synapses, Transport of small molecules
UniProt: Q8JZR4
Entrez ID: 242607
|
Does Knockout of Zdhhc20 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Zdhhc20
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zdhhc20 (zinc finger, DHHC domain containing 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: host-mediated activation of viral process, peptidyl-L-cysteine S-palmitoylation, protein palmitoylation, protein targeting to membrane, synaptic vesicle maturation, virion attachment to host cell; MF: acyltransferase activity, metal ion binding, palmitoyltransferase activity, protein-cysteine S-myristoyltransferase activity, protein-cysteine S-palmitoyltransferase activity, protein-cysteine S-stearoyltransferase activity, transferase activity, zinc ion binding; CC: Golgi apparatus, Golgi membrane, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q5Y5T1
Entrez ID: 75965
|
Does Knockout of Trmt112 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Trmt112
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Trmt112 (tRNA methyltransferase 11-2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of LSU-rRNA, maturation of SSU-rRNA, peptidyl-glutamine methylation, positive regulation of rRNA processing, rRNA (guanine-N7)-methylation, rRNA methylation, tRNA methylation, transcription initiation-coupled chromatin remodeling; MF: protein binding, protein heterodimerization activity, protein methyltransferase activity, tRNA methyltransferase activator activity; CC: cytoplasm, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex, tRNA (m2G10) methyltransferase complex
Pathways: Biological oxidations, Eukaryotic Translation Termination, Metabolism, Metabolism of proteins, Methylation, Phase II - Conjugation of compounds, Translation
UniProt: Q9DCG9
Entrez ID: 67674
|
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