prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Grik1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Grik1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Grik1 (glutamate receptor, ionotropic, kainate 1)
Type: protein-coding
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: L-glutamate transmembrane transport, adult behavior, behavioral response to pain, calcium-mediated signaling, establishment of localization in cell, excitatory postsynaptic potential, inhibitory postsynaptic potential, ionotropic glutamate receptor signaling pathway, membrane depolarization, modulation of chemical synaptic transmission, modulation of excitatory postsynaptic potential, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of synaptic transmission, GABAergic, negative regulation of synaptic transmission, glutamatergic, nervous system development, positive regulation of gamma-aminobutyric acid secretion, positive regulation of synaptic transmission, GABAergic, presynaptic modulation of chemical synaptic transmission, regulation of long-term neuronal synaptic plasticity, regulation of membrane potential, regulation of short-term neuronal synaptic plasticity, synaptic transmission, glutamatergic; MF: L-glutamate transmembrane transporter activity, SNARE binding, extracellularly glutamate-gated ion channel activity, glutamate binding, glutamate-gated calcium ion channel activity, glutamate-gated receptor activity, heterocyclic compound binding, identical protein binding, kainate selective glutamate receptor activity, ligand-gated monoatomic cation channel activity, ligand-gated monoatomic ion channel activity, ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, monoatomic ion channel activity, protein binding, scaffold protein binding, signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: dendrite, glutamatergic synapse, ionotropic glutamate receptor complex, kainate selective glutamate receptor complex, membrane, neuron to neuron synapse, neuronal cell body, plasma membrane, postsynapse, postsynaptic density, postsynaptic density membrane, postsynaptic membrane, presynaptic membrane, receptor complex, synapse, terminal bouton
Pathways: Glutamatergic synapse - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse)
UniProt: Q8BRT2, Q3UZT1, A0A2I3BQM2, A0A2I3BPT2, F6Z3M4, A0A1B0GSI4, F6QF13, Q8C825, Q8BQZ0, A0A2I3BRJ1, E9Q2Y1
Entrez ID: 14805
|
Does Knockout of Med8 in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Med8
|
response to virus
|
Microglial Cell Line
|
Gene: Med8 (mediator complex subunit 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, regulation of transcription by RNA polymerase II; MF: RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, transcription coregulator activity, ubiquitin protein ligase activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways:
UniProt: Q9D7W5
Entrez ID: 80509
|
Does Knockout of Tmem53 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Tmem53
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tmem53 (transmembrane protein 53)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, negative regulation of BMP signaling pathway, negative regulation of ossification, negative regulation of osteoblast differentiation, regulation of nucleocytoplasmic transport; CC: membrane, nuclear membrane, nuclear outer membrane, nucleus
Pathways:
UniProt: Q9D0Z3
Entrez ID: 68777
|
Does Knockout of Mfsd4b5 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Mfsd4b5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mfsd4b5 (major facilitator superfamily domain containing 4B5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-glucose import across plasma membrane, monoatomic ion transport, sodium ion transport, transmembrane transport; MF: symporter activity, transmembrane transporter activity; CC: apical plasma membrane, brush border membrane, cellular_component, membrane
Pathways:
UniProt: Q8C3P4, Q3TN71, E9PYY6, E9Q694, F6YK23
Entrez ID: 215928
|
Does Knockout of Add2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Add2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Add2 (adducin 2)
Type: protein-coding
Summary: This gene encodes the beta subunit of the adducin family. Adducins, encoded by alpha, beta and gamma genes, are heteromeric proteins that crosslink actin filaments with spectrin at the cytoskeletal membrane. This protein, primarily found in the brain and hematopoietic cells, is regulated by phosphorylation and calmodulin interactions as it promotes spectrin assembly onto actin filaments, bundles actin and caps barbed ends of actin filaments. In mouse, deficiency of this gene can lead to mild hemolytic anemia and impaired synaptic plasticity. Mutations of this gene in mouse serve as a pathophysiological model for hereditary spherocytosis and hereditary elliptocytosis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: actin cytoskeleton organization, actin filament bundle assembly, barbed-end actin filament capping, hemopoiesis, leukocyte migration, leukocyte tethering or rolling, monoatomic ion transport, protein-containing complex assembly, synapse assembly; MF: actin binding, actin filament binding, calmodulin binding, cytoskeletal anchor activity, protein dimerization activity, protein heterodimerization activity, protein homodimerization activity, protein kinase binding, spectrin binding, structural constituent of cytoskeleton; CC: F-actin capping protein complex, cytoplasm, cytoplasmic vesicle, cytoskeleton, glutamatergic synapse, membrane, plasma membrane, plasma membrane raft, postsynapse, postsynaptic density
Pathways: Miscellaneous transport and binding events, Transport of small molecules
UniProt: Q9QYB8
Entrez ID: 11519
|
Does Knockout of Mir467c in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Mir467c
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Mir467c (microRNA 467c)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100124487
|
Does Knockout of Elk4 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Elk4
|
cell cycle progression
|
breast epithelium
|
Gene: Elk4 (ELK4, member of ETS oncogene family)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; and retina. Orthologous to human ELK4 (ETS transcription factor ELK4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: cytosol, nucleoplasm, nucleus
Pathways: Human T-cell leukemia virus 1 infection - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: P41158
Entrez ID: 13714
|
Does Knockout of Fbxo33 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Fbxo33
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Fbxo33 (F-box protein 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of protein ubiquitination, protein ubiquitination
Pathways:
UniProt: Q8VE08
Entrez ID: 70611
|
Does Knockout of Pou1f1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 163
|
Knockout
|
Pou1f1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Pou1f1 (POU domain, class 1, transcription factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, adenohypophysis development, cell fate specification, determination of adult lifespan, negative regulation of transcription by RNA polymerase II, pituitary gland development, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of inositol trisphosphate biosynthetic process, positive regulation of macromolecule biosynthetic process, positive regulation of multicellular organism growth, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of gene expression, regulation of insulin-like growth factor receptor signaling pathway, regulation of transcription by RNA polymerase II, somatotropin secreting cell development, somatotropin secreting cell differentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, lncRNA binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, cytosol, nucleoplasm, nucleus, transcription regulator complex
Pathways: Growth hormone synthesis, secretion and action - Mus musculus (mouse)
UniProt: Q00286
Entrez ID: 18736
|
Does Knockout of Rnaseh2c in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Rnaseh2c
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Rnaseh2c (ribonuclease H2, subunit C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA catabolic process, mismatch repair; CC: nucleus, ribonuclease H2 complex
Pathways: DNA replication - Mus musculus (mouse)
UniProt: Q9CQ18
Entrez ID: 68209
|
Does Knockout of Prmt3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Prmt3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Prmt3 (protein arginine N-methyltransferase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, dendritic spine morphogenesis, methylation, negative regulation of protein ubiquitination, negative regulation of retinoic acid biosynthetic process, positive regulation of osteoblast differentiation, regulation of DNA-templated transcription, transcription initiation-coupled chromatin remodeling; MF: histone H4R3 methyltransferase activity, histone methyltransferase activity, metal ion binding, methyltransferase activity, modified amino acid binding, protein-arginine N-methyltransferase activity, protein-arginine omega-N asymmetric methyltransferase activity, protein-arginine omega-N monomethyltransferase activity, transferase activity, zinc ion binding; CC: cytoplasm, cytosol, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Metabolism of proteins, Post-translational protein modification, Protein methylation, RMTs methylate histone arginines
UniProt: Q922H1
Entrez ID: 71974
|
Does Knockout of Gab2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Gab2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gab2 (growth factor receptor bound protein 2-associated protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, cell surface receptor protein tyrosine kinase signaling pathway, integrin-mediated signaling pathway, intracellular signal transduction, osteoclast differentiation, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of cell population proliferation, positive regulation of epithelial cell migration, positive regulation of mast cell degranulation, signal transduction; MF: phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding, protein binding, protein domain specific binding, protein phosphatase binding, transmembrane receptor protein tyrosine kinase adaptor activity; CC: cytoplasm, cytosol, membrane, membrane raft, plasma membrane, protein-containing complex
Pathways: Chronic myeloid leukemia - Mus musculus (mouse), Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse)
UniProt: Q3ZB57, Q3ZB59
Entrez ID: 14389
|
Does Knockout of Ppm1d in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Ppm1d
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ppm1d (protein phosphatase 1D magnesium-dependent, delta isoform)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, signal transduction by p53 class mediator, DNA methylation-dependent constitutive heterochromatin formation, G2/M transition of mitotic cell cycle, cellular response to starvation, negative regulation of gene expression, epigenetic, regulation of intracellular signal transduction, response to bacterium; MF: cation binding, hydrolase activity, metal ion binding, mitogen-activated protein kinase binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity; CC: cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Transcriptional regulation by RUNX2, p53 signaling pathway - Mus musculus (mouse)
UniProt: Q9QZ67
Entrez ID: 53892
|
Does Knockout of Prr5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Prr5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Prr5 (proline rich 5 (renal))
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and positive regulation of protein phosphorylation. Predicted to be part of TORC2 complex. Orthologous to human PRR5 (proline rich 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: TORC2 signaling, actin cytoskeleton organization, cellular response to nutrient levels, cytoskeleton organization, negative regulation of apoptotic process, positive regulation of cell growth, positive regulation of cell migration, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; CC: TORC2 complex
Pathways: Adaptive Immune System, CD28 dependent PI3K/Akt signaling, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Co-stimulation by CD28, Gene expression (Transcription), Generic Transcription Pathway, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Immune System, Intracellular signaling by second messengers, PIP3 activates AKT signaling, RNA Polymerase II Transcription, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Response of endothelial cells to shear stress, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, Transcriptional Regulation by TP53, VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q812A5
Entrez ID: 109270
|
Does Knockout of Pigv in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Pigv
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pigv (phosphatidylinositol glycan anchor biosynthesis, class V)
Type: protein-coding
Summary: Predicted to enable mannosyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be part of mannosyltransferase complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 1. Orthologous to human PIGV (phosphatidylinositol glycan anchor biosynthesis class V). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: GPI anchor biosynthetic process; MF: GPI mannosyltransferase activity, alpha-1,6-mannosyltransferase activity, glycosyltransferase activity, mannosyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, mannosyltransferase complex, membrane
Pathways: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Mus musculus (mouse), Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification, Synthesis of glycosylphosphatidylinositol (GPI)
UniProt: Q7TPN3
Entrez ID: 230801
|
Does Knockout of Gpr139 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Gpr139
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Gpr139 (G protein-coupled receptor 139)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, neuropeptide signaling pathway, phospholipase C-activating G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity, identical protein binding, neuropeptide receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q80UC8
Entrez ID: 209776
|
Does Knockout of Terf2ip in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,541
|
Knockout
|
Terf2ip
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Terf2ip (telomeric repeat binding factor 2, interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction, negative regulation of DNA recombination at telomere, negative regulation of telomere maintenance, positive regulation of NF-kappaB transcription factor activity, positive regulation of canonical NF-kappaB signal transduction, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of telomere maintenance, protection from non-homologous end joining at telomere, protein localization to chromosome, telomeric region, regulation of DNA-templated transcription, regulation of double-strand break repair via homologous recombination, regulation of telomere maintenance, telomere capping, telomere maintenance, telomere maintenance via telomere lengthening, telomeric loop formation; MF: G-rich strand telomeric DNA binding, phosphatase binding, protein binding, telomeric DNA binding; CC: chromosome, chromosome, telomeric region, cytoplasm, male germ cell nucleus, nuclear body, nuclear telomere cap complex, nucleoplasm, nucleus, shelterin complex
Pathways: Base Excision Repair, Base-Excision Repair, AP Site Formation, Cell Cycle, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Chromosome Maintenance, Cleavage of the damaged purine, DNA Damage/Telomere Stress Induced Senescence, DNA Repair, Depurination, Extension of Telomeres, Inhibition of DNA recombination at telomere, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Recognition and association of DNA glycosylase with site containing an affected purine, Removal of the Flap Intermediate from the C-strand, Telomere C-strand (Lagging Strand) Synthesis, Telomere C-strand synthesis initiation, Telomere Extension By Telomerase, Telomere Maintenance
UniProt: Q91VL8
Entrez ID: 57321
|
Does Knockout of Slc7a7 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Slc7a7
|
response to bacteria
|
renal medulla cell line
|
Gene: Slc7a7 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-arginine transmembrane transport, L-leucine transport, amino acid transmembrane transport, amino acid transport, regulation of arginine metabolic process, transmembrane transport; MF: L-amino acid transmembrane transporter activity, L-arginine transmembrane transporter activity, basic amino acid transmembrane transporter activity, transmembrane transporter activity; CC: basolateral plasma membrane, membrane, plasma membrane
Pathways: Amino acid transport across the plasma membrane, Basigin interactions, Cell surface interactions at the vascular wall, Hemostasis, Protein digestion and absorption - Mus musculus (mouse), SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Transport of small molecules
UniProt: Q9Z1K8
Entrez ID: 20540
|
Does Knockout of Echdc1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Echdc1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Echdc1 (enoyl Coenzyme A hydratase domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carboxy-lyase activity, catalytic activity, lyase activity, methyl/ethyl malonyl-CoA decarboxylase activity; CC: cytoplasm, cytosol
Pathways: Propanoate metabolism - Mus musculus (mouse)
UniProt: Q9D9V3
Entrez ID: 52665
|
Does Knockout of Agtr2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Agtr2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Agtr2 (angiotensin II receptor, type 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger, angiotensin-activated signaling pathway, angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure, blood vessel diameter maintenance, brain renin-angiotensin system, cell growth involved in cardiac muscle cell development, cell surface receptor signaling pathway, cellular response to dexamethasone stimulus, cerebellar cortex development, dopamine biosynthetic process, exploration behavior, inflammatory response, intracellular sodium ion homeostasis, kidney morphogenesis, negative regulation of fibroblast proliferation, negative regulation of heart rate, negative regulation of icosanoid secretion, negative regulation of neurotrophin TRK receptor signaling pathway, negative regulation of norepinephrine secretion, nitric oxide-cGMP-mediated signaling, positive regulation of DNA-templated transcription, positive regulation of branching involved in ureteric bud morphogenesis, positive regulation of cell population proliferation, positive regulation of cytokine production, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of metanephric glomerulus development, regulation of apoptotic process, regulation of blood volume by renin-angiotensin, regulation of metanephros size, regulation of protein import into nucleus, regulation of systemic arterial blood pressure by circulatory renin-angiotensin, renal system process involved in regulation of systemic arterial blood pressure, renin-angiotensin regulation of aldosterone production, signal transduction, vasodilation; MF: G protein-coupled receptor activity, angiotensin type II receptor activity; CC: membrane, perinuclear region of cytoplasm, plasma membrane
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Renin-angiotensin system - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: P35374
Entrez ID: 11609
|
Does Knockout of Yaf2 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Yaf2
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Yaf2 (YY1 associated factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription; MF: DNA binding, metal ion binding, protein binding, transcription coactivator activity, transcription coregulator activity, transcription corepressor activity, zinc ion binding; CC: cytosol, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, Transcriptional Regulation by E2F6, Transcriptional regulation by RUNX1
UniProt: Q99LW6
Entrez ID: 67057
|
Does Knockout of Mrpl14 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Mrpl14
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Mrpl14 (mitochondrial ribosomal protein L14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9D1I6
Entrez ID: 68463
|
Does Knockout of A130010J15Rik in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
A130010J15Rik
|
protein/peptide distribution
|
myoblast cell line
|
Gene: A130010J15Rik (RIKEN cDNA A130010J15 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9DAE8
Entrez ID: 319266
|
Does Knockout of Laptm5 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Laptm5
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Laptm5 (lysosomal-associated protein transmembrane 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to lysosome transport, cellular response to leukemia inhibitory factor, defense response to tumor cell, induction of programmed cell death, intracellular protein transport, intrinsic apoptotic signaling pathway, negative regulation of B cell activation, negative regulation of T cell activation, negative regulation of T cell receptor signaling pathway, negative regulation of activated T cell proliferation, negative regulation of autophagic cell death, negative regulation of interleukin-2 production, negative regulation of pre-B cell receptor expression, negative regulation of type II interferon production, positive regulation of MAPK cascade, positive regulation of cytokine production involved in immune response, positive regulation of interleukin-12 production, positive regulation of interleukin-6 production, positive regulation of lysosomal membrane permeability, positive regulation of macrophage cytokine production, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of protein ubiquitination, positive regulation of proteolysis involved in protein catabolic process, positive regulation of receptor catabolic process, positive regulation of tumor necrosis factor-mediated signaling pathway, positive regulation of ubiquitin-dependent protein catabolic process, protein localization to lysosome, protein targeting to lysosome; MF: enzyme binding, protein binding, protein sequestering activity, ubiquitin protein ligase binding; CC: cytoplasmic vesicle, cytosol, lysosomal membrane, lysosome, membrane, perinuclear region of cytoplasm, plasma membrane, protein-containing complex, transport vesicle
Pathways: Lysosome - Mus musculus (mouse)
UniProt: Q61168
Entrez ID: 16792
|
Does Knockout of Mamld1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Mamld1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Mamld1 (mastermind-like domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: male gonad development, regulation of transcription by RNA polymerase II, spermatid differentiation, spermatogenesis; CC: Golgi apparatus, centrosome, nuclear body, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, NOTCH1 Intracellular Domain Regulates Transcription, Notch-HLH transcription pathway, RNA Polymerase II Transcription, RUNX3 regulates NOTCH signaling, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH1, Transcriptional regulation by RUNX3
UniProt: P0C6A2
Entrez ID: 333639
|
Does Knockout of Ptprf in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Ptprf
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ptprf (protein tyrosine phosphatase receptor type F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell migration, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of cell population proliferation, negative regulation of cell projection organization, negative regulation of cytokine-mediated signaling pathway, negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of insulin receptor signaling pathway, negative regulation of neurotrophin TRK receptor signaling pathway, negative regulation of receptor binding, nervous system development, neuron projection regeneration, peptidyl-tyrosine dephosphorylation, positive regulation of apoptotic process, positive regulation of dendrite morphogenesis, positive regulation of neuron apoptotic process, regulation of axon regeneration, regulation of neuron projection development, regulation of postsynapse organization, regulation of synapse structure or activity, signal transduction, synaptic membrane adhesion; MF: cell adhesion molecule binding, chondroitin sulfate proteoglycan binding, glycosaminoglycan binding, heparin binding, hydrolase activity, insulin receptor binding, phosphate ion binding, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity, protein-containing complex binding, receptor tyrosine kinase binding, sulfur compound binding, transmembrane receptor protein tyrosine phosphatase activity; CC: endosome, excitatory synapse, growth cone, membrane, neuron projection, neuronal cell body, postsynaptic density membrane
Pathways: Adherens junction - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Insulin receptor recycling, Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Neuronal System, Protein-protein interactions at synapses, Receptor-type tyrosine-protein phosphatases, Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic adhesion-like molecules
UniProt: A2A8L5
Entrez ID: 19268
|
Does Knockout of Rpe65 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Rpe65
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Rpe65 (retinal pigment epithelium 65)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: camera-type eye development, circadian rhythm, detection of light stimulus involved in visual perception, lipid metabolic process, neural retina development, response to light stimulus, retina homeostasis, retinal metabolic process, retinoid metabolic process, retinol metabolic process, visual perception, zeaxanthin biosynthetic process; MF: all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity, all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity, beta-carotene 15,15'-dioxygenase activity, cardiolipin binding, hydrolase activity, isomerase activity, metal ion binding, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, phosphatidylcholine binding, phosphatidylserine binding, protein binding, retinol isomerase activity; CC: cell body, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus, plasma membrane
Pathways: Retinol metabolism - Mus musculus (mouse), Sensory Perception, The canonical retinoid cycle in rods (twilight vision), Visual phototransduction
UniProt: Q91ZQ5
Entrez ID: 19892
|
Does Knockout of Lrrc4b in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Lrrc4b
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Lrrc4b (leucine rich repeat containing 4B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of synapse assembly, regulation of postsynaptic density assembly, regulation of presynapse assembly, synaptic membrane adhesion; MF: cell-cell adhesion mediator activity, protein binding, signaling receptor binding; CC: cell projection, cerebellar mossy fiber, glutamatergic synapse, membrane, plasma membrane, postsynaptic density membrane, presynaptic membrane, synapse
Pathways: Cell adhesion molecules - Mus musculus (mouse), Neuronal System, Protein-protein interactions at synapses, Receptor-type tyrosine-protein phosphatases
UniProt: P0C192
Entrez ID: 272381
|
Does Knockout of Oplah in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Oplah
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Oplah (5-oxoprolinase (ATP-hydrolysing))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glutathione metabolic process; MF: 5-oxoprolinase (ATP-hydrolyzing) activity, ATP binding, catalytic activity, hydrolase activity, identical protein binding, nucleotide binding; CC: cytoplasm, cytosol
Pathways: γ-glutamyl cycle, Biological oxidations, Glutathione conjugation, Glutathione metabolism - Mus musculus (mouse), Glutathione synthesis and recycling, Metabolism, Phase II - Conjugation of compounds
UniProt: Q8K010
Entrez ID: 75475
|
Does Knockout of Lag3 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
Lag3
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Lag3 (lymphocyte-activation gene 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, cell surface receptor signaling pathway, immune system process, innate immune response, negative regulation of T cell activation, negative regulation of interleukin-2 production, negative regulation of regulatory T cell differentiation, plasmacytoid dendritic cell activation, positive regulation of natural killer cell mediated cytotoxicity, regulation of immune response; MF: MHC class II protein binding, protein binding, transmembrane signaling receptor activity; CC: cell surface, external side of plasma membrane, extracellular region, membrane, plasma membrane
Pathways: Adaptive Immune System, Immune System, MHC class II antigen presentation
UniProt: Q61790
Entrez ID: 16768
|
Does Knockout of Cd300a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Cd300a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cd300a (CD300A molecule)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment of localization in cell, immune system process, intracellular signal transduction, negative regulation of B cell proliferation, negative regulation of B cell receptor signaling pathway, negative regulation of MyD88-dependent toll-like receptor signaling pathway, negative regulation of NK T cell activation, negative regulation of eosinophil activation, negative regulation of eosinophil migration, negative regulation of fibroblast proliferation, negative regulation of mast cell activation involved in immune response, negative regulation of mast cell degranulation, negative regulation of neutrophil activation, negative regulation of phagocytosis, engulfment, negative regulation of serotonin secretion, receptor-mediated endocytosis, regulation of T cell receptor signaling pathway, regulation of innate immune response, serotonin secretion by mast cell, signal transduction; MF: phosphatase binding, phosphatidylethanolamine binding, phosphatidylserine binding, protein binding, signaling receptor activity, transmembrane signaling receptor activity; CC: membrane, plasma membrane
Pathways: Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
UniProt: Q6SJQ0
Entrez ID: 217303
|
Does Knockout of Scn4a in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Scn4a
|
phagocytosis
|
macrophage
|
Gene: Scn4a (sodium channel, voltage-gated, type IV, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: choline transport, membrane depolarization during action potential, monoatomic cation transport, monoatomic ion transmembrane transport, monoatomic ion transport, neuronal action potential, potassium ion transport, regulation of skeletal muscle contraction by action potential, sensory perception of pain, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: monoatomic cation channel activity, monoatomic ion channel activity, sodium channel activity, voltage-gated sodium channel activity; CC: axon, membrane, monoatomic ion channel complex, plasma membrane, voltage-gated sodium channel complex
Pathways:
UniProt: Q9ER60
Entrez ID: 110880
|
Does Knockout of Zfp13 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Zfp13
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zfp13 (zinc finger protein 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, positive regulation of hydrogen peroxide biosynthetic process, positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: mitochondrion, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: P10754
Entrez ID: 22654
|
Does Knockout of Rai14 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Rai14
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rai14 (retinoic acid induced 14)
Type: protein-coding
Summary: Predicted to enable actin binding activity. Predicted to be involved in cell differentiation and spermatogenesis. Located in mitochondrion. Is expressed in several structures, including brain; genitourinary system; jaw; neural ectoderm; and retina. Orthologous to human RAI14 (retinoic acid induced 14). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, spermatogenesis; CC: anchoring junction, cell cortex, cytoplasm, cytoskeleton, cytosol, fibrillar center, mitochondrion, nucleoplasm, nucleus, stress fiber
Pathways:
UniProt: Q9EP71
Entrez ID: 75646
|
Does Knockout of Ikzf3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Ikzf3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ikzf3 (IKAROS family zinc finger 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, B cell differentiation, T cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of B cell differentiation, regulation of B cell proliferation, regulation of apoptotic process, regulation of lymphocyte differentiation, regulation of transcription by RNA polymerase II, response to bacterium; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, histone deacetylase binding, identical protein binding, metal ion binding, promoter-specific chromatin binding, protein binding, protein heterodimerization activity, protein homodimerization activity, sequence-specific DNA binding, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: O08900
Entrez ID: 22780
|
Does Knockout of Arl6ip6 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Arl6ip6
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Arl6ip6 (ADP-ribosylation factor-like 6 interacting protein 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, nuclear inner membrane, nucleus
Pathways:
UniProt: Q8BH07
Entrez ID: 65103
|
Does Knockout of Cpne8 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Cpne8
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cpne8 (copine VIII)
Type: protein-coding
Summary: This gene encodes a member of the copine family of highly conserved, calcium-dependent phospholipid binding proteins. The encoded protein has two characteristic C2 domains and a VWFA domain and may play a role in membrane trafficking. A related pseudogene is found on chromosome 8. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: calcium-dependent phospholipid binding, metal ion binding
Pathways: RHO GTPase cycle, RHOD GTPase cycle, RHOQ GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9DC53
Entrez ID: 66871
|
Does Knockout of Uts2r in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,175
|
Knockout
|
Uts2r
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Uts2r (urotensin 2 receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, blood circulation, blood vessel diameter maintenance, negative regulation of blood pressure, negative regulation of glomerular filtration, negative regulation of urine volume, neuropeptide signaling pathway, positive regulation of angiogenesis, positive regulation of blood pressure, positive regulation of cell growth, positive regulation of circadian sleep/wake cycle, REM sleep, positive regulation of circadian sleep/wake cycle, wakefulness, positive regulation of cytosolic calcium ion concentration, positive regulation of fibroblast proliferation, positive regulation of vasoconstriction, regulation of blood pressure, signal transduction; MF: G protein-coupled receptor activity, urotensin II receptor activity; CC: early endosome, membrane, plasma membrane, recycling endosome
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q8VIH9
Entrez ID: 217369
|
Does Knockout of Tbc1d5 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Tbc1d5
|
cell proliferation
|
Regulatory T cell
|
Gene: Tbc1d5 (TBC1 domain family, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, macroautophagy, positive regulation of receptor internalization, protein transport, response to starvation, retrograde transport, endosome to Golgi; MF: AP-2 adaptor complex binding, GTPase activator activity, retromer complex binding; CC: AP-2 adaptor complex, Atg1/ULK1 kinase complex, Golgi apparatus, autophagosome, cytoplasm, cytoplasmic vesicle, cytosol, endosome, endosome membrane, membrane, retromer complex
Pathways:
UniProt: Q80XQ2
Entrez ID: 72238
|
Does Knockout of Prpf38b in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Prpf38b
|
cell proliferation
|
Regulatory T cell
|
Gene: Prpf38b (PRP38 pre-mRNA processing factor 38 (yeast) domain containing B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, biological_process, mRNA processing; CC: nucleus, precatalytic spliceosome, spliceosomal complex
Pathways: Spliceosome - Mus musculus (mouse)
UniProt: Q80SY5
Entrez ID: 66921
|
Does Knockout of Selp in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,179
|
Knockout
|
Selp
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Selp (selectin, platelet)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell-cell adhesion, cellular response to interleukin-6, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, inflammatory response, leukocyte cell-cell adhesion, leukocyte migration, leukocyte tethering or rolling, positive regulation of cell adhesion, positive regulation of leukocyte migration, positive regulation of leukocyte tethering or rolling, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of platelet activation, regulation of cellular extravasation, regulation of integrin activation, response to cytokine; MF: calcium ion binding, calcium-dependent protein binding, carbohydrate binding, fucose binding, heparin binding, integrin binding, lipopolysaccharide binding, metal ion binding, oligosaccharide binding, protein binding, sialic acid binding; CC: external side of plasma membrane, extracellular space, membrane, plasma membrane, platelet alpha granule membrane
Pathways: Cell adhesion molecules - Mus musculus (mouse), Cell surface interactions at the vascular wall, Coronavirus disease - COVID-19 - Mus musculus (mouse), Hemostasis, Lipid and atherosclerosis - Mus musculus (mouse), Malaria - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+, Staphylococcus aureus infection - Mus musculus (mouse)
UniProt: Q01102
Entrez ID: 20344
|
Does Knockout of Slc22a8 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Slc22a8
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slc22a8 (solute carrier family 22 (organic anion transporter), member 8)
Type: protein-coding
Summary: Enables antiporter activity and organic anion transmembrane transporter activity. Predicted to be involved in glutathione transport; prostaglandin transport; and quaternary ammonium group transport. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; liver; spleen; and thyroid gland. Orthologous to human SLC22A8 (solute carrier family 22 member 8). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: glutathione transport, inorganic anion transport, lipid transport, monoatomic ion transport, organic anion transport, prostaglandin transport, quaternary ammonium group transport, response to toxic substance, transmembrane transport, xenobiotic transport; MF: antiporter activity, organic anion transmembrane transporter activity, prostaglandin transmembrane transporter activity, protein kinase C binding, quaternary ammonium group transmembrane transporter activity, solute:inorganic anion antiporter activity, transmembrane transporter activity, xenobiotic transmembrane transporter activity; CC: apical plasma membrane, basolateral plasma membrane, membrane, plasma membrane
Pathways: Bile secretion - Mus musculus (mouse), Organic anion transport by SLC22 transporters, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Transport of small molecules
UniProt: O88909
Entrez ID: 19879
|
Does Knockout of Zyg11b in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Zyg11b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zyg11b (zyg-ll family member B, cell cycle regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein quality control for misfolded or incompletely synthesized proteins; CC: Cul2-RING ubiquitin ligase complex
Pathways:
UniProt: Q3UFS0
Entrez ID: 414872
|
Does Knockout of Pdcd6ip in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Pdcd6ip
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pdcd6ip (programmed cell death 6 interacting protein)
Type: protein-coding
Summary: Enables identical protein binding activity and protein dimerization activity. Involved in several processes, including actomyosin contractile ring assembly; bicellular tight junction assembly; and maintenance of epithelial cell apical/basal polarity. Located in actomyosin; cytosol; and extracellular exosome. Is expressed in several structures, including branchial arch; facial prominence; gut; limb bud; and neural fold. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 29. Orthologous to human PDCD6IP (programmed cell death 6 interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: actomyosin contractile ring assembly, apoptotic process, bicellular tight junction assembly, cell division, extracellular exosome biogenesis, macroautophagy, maintenance of epithelial cell apical/basal polarity, midbody abscission, mitotic cytokinesis, positive regulation of exosomal secretion, positive regulation of extracellular exosome assembly, protein homooligomerization, protein transport, regulation of centrosome duplication, regulation of extracellular exosome assembly, regulation of membrane permeability, ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway, viral budding, viral budding via host ESCRT complex; MF: SH3 domain binding, calcium-dependent protein binding, identical protein binding, protein binding, protein dimerization activity, protein homodimerization activity, proteinase activated receptor binding; CC: Flemming body, actomyosin, anchoring junction, bicellular tight junction, centrosome, cytoplasm, cytoskeleton, cytosol, endoplasmic reticulum exit site, endosome, extracellular exosome, extracellular region, immunological synapse, melanosome, myelin sheath, neuronal cell body, perinuclear region of cytoplasm
Pathways: Endocytosis - Mus musculus (mouse)
UniProt: Q9WU78
Entrez ID: 18571
|
Does Knockout of 1700029H14Rik in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
1700029H14Rik
|
protein/peptide distribution
|
myoblast cell line
|
Gene: 1700029H14Rik (RIKEN cDNA 1700029H14 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D9Y4, G3X906, E9PY36
Entrez ID: 66501
|
Does Knockout of Rpl35a in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Rpl35a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rpl35a (ribosomal protein L35A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, rRNA processing, ribosomal large subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: ribonucleoprotein complex binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, mitochondrion, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: O55142
Entrez ID: 57808
|
Does Knockout of Pcdh9 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Pcdh9
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pcdh9 (protocadherin 9)
Type: protein-coding
Summary: This gene encodes a member of the protocadherin family, and cadherin superfamily, of transmembrane proteins containing cadherin domains. These proteins mediate cell adhesion in neural tissues in the presence of calcium. The encoded protein may be involved in signaling at neuronal synaptic junctions. Sharing a characteristic with other protocadherin genes, this gene has a notably large exon that encodes multiple cadherin domains and a transmembrane region. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, protein binding; CC: cell-cell contact zone, glutamatergic synapse, growth cone, membrane, plasma membrane, synaptic membrane
Pathways:
UniProt: A0A0A6YWY8, F8VPK8, A0A0A6YY37, A0A0A6YY09, A0A0A6YWM0, A0A0A6YVP5
Entrez ID: 211712
|
Does Knockout of Numbl in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Numbl
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Numbl (numb-like)
Type: protein-coding
Summary: Involved in lateral ventricle development; neuroblast division in subventricular zone; and positive regulation of neurogenesis. Acts upstream of or within adherens junction organization and nervous system development. Located in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; peripheral nervous system ganglion; and sensory organ. Orthologous to human NUMBL (NUMB like endocytic adaptor protein). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: adherens junction organization, axonogenesis, cytokine-mediated signaling pathway, forebrain development, lateral ventricle development, nervous system development, neuroblast division in subventricular zone, neuroblast proliferation, positive regulation of dendrite morphogenesis, positive regulation of neurogenesis, protein metabolic process, regulation of postsynapse assembly; CC: cytoplasm, glutamatergic synapse
Pathways: Notch signaling pathway - Mus musculus (mouse)
UniProt: O08919
Entrez ID: 18223
|
Does Knockout of Arxes1 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Arxes1
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Arxes1 (adipocyte-related X-chromosome expressed sequence 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fat cell differentiation, protein targeting to ER, signal peptide processing; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, signal peptidase complex
Pathways: Protein export - Mus musculus (mouse)
UniProt: C0HK79
Entrez ID: 76219
|
Does Knockout of Rgs8 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Rgs8
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rgs8 (regulator of G-protein signaling 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled acetylcholine receptor signaling pathway, G protein-coupled receptor signaling pathway, negative regulation of signal transduction, positive regulation of GTPase activity, regulation of dopamine receptor signaling pathway; MF: G-protein alpha-subunit binding, GTPase activator activity; CC: cell projection, cytoplasmic side of plasma membrane, dendrite, membrane, neuronal cell body membrane, nucleus, perikaryon, plasma membrane, synapse
Pathways: G alpha (i) signalling events, GPCR downstream signalling, Signal Transduction, Signaling by GPCR
UniProt: Q8BXT1
Entrez ID: 67792
|
Does Knockout of Actn3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Actn3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Actn3 (actinin alpha 3)
Type: protein-coding
Summary: This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: actin cytoskeleton organization, bone morphogenesis, focal adhesion assembly, muscle cell development, muscle contraction, negative regulation of calcineurin-NFAT signaling cascade, negative regulation of cold-induced thermogenesis, negative regulation of glycolytic process, negative regulation of oxidative phosphorylation, negative regulation of relaxation of muscle, osteoblast differentiation, positive regulation of bone mineralization involved in bone maturation, positive regulation of fast-twitch skeletal muscle fiber contraction, positive regulation of glucose catabolic process to lactate via pyruvate, positive regulation of skeletal muscle fiber development, positive regulation of skeletal muscle tissue growth, regulation of aerobic respiration, regulation of muscle system process, regulation of the force of skeletal muscle contraction, response to denervation involved in regulation of muscle adaptation, skeletal muscle atrophy, transition between fast and slow fiber; MF: actin binding, actin filament binding, calcium ion binding, identical protein binding, metal ion binding, protein binding, protein-macromolecule adaptor activity, transmembrane transporter binding; CC: Z disc, actin cytoskeleton, brush border, cell junction, cell projection, cortical actin cytoskeleton, focal adhesion, plasma membrane, sarcomere, striated muscle thin filament
Pathways: Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Muscle contraction, Striated Muscle Contraction
UniProt: O88990
Entrez ID: 11474
|
Does Knockout of Gfra3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Gfra3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Gfra3 (glial cell line derived neurotrophic factor family receptor alpha 3)
Type: protein-coding
Summary: This gene encodes a cell surface glycoprotein and member of the glial cell line-derived neurotrophic receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein mediates binding of the ligand artemin to the ret receptor tyrosine kinase, and this interaction may regulate thermal pain and axon regeneration. Homozygous knockout mice for this gene exhibit impaired proliferation of cultured neuroblasts and impaired development of the superior cervical ganglion. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: axon guidance, cell surface receptor protein tyrosine kinase signaling pathway, glial cell-derived neurotrophic factor receptor signaling pathway, nervous system development, neuron development, neuron migration, sympathetic nervous system development; MF: axon guidance receptor activity, coreceptor activity, glial cell-derived neurotrophic factor receptor activity, protein binding, signaling receptor activity, transmembrane signaling receptor activity; CC: cytosol, external side of plasma membrane, membrane, plasma membrane, receptor complex, side of membrane
Pathways: Axon guidance, Developmental Biology, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Nervous system development, RAF/MAP kinase cascade, RET signaling, Signal Transduction
UniProt: O35118
Entrez ID: 14587
|
Does Knockout of Ubl4b in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Ubl4b
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ubl4b (ubiquitin-like 4B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, cytoplasm
Pathways:
UniProt: Q9CQ84
Entrez ID: 67591
|
Does Knockout of Zc3hc1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Zc3hc1
|
phagocytosis
|
macrophage
|
Gene: Zc3hc1 (zinc finger, C3HC type 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, protein ubiquitination; MF: metal ion binding, protein kinase binding, zinc ion binding; CC: nuclear envelope, nuclear membrane, nuclear pore nuclear basket, nucleoplasm, nucleus
Pathways:
UniProt: Q80YV2
Entrez ID: 232679
|
Does Knockout of Zfp821 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Zfp821
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Zfp821 (zinc finger protein 821)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding
Pathways:
UniProt: Q6PD05
Entrez ID: 75871
|
Does Knockout of Ctsm in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Ctsm
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Ctsm (cathepsin M)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: collagen catabolic process, fusion of virus membrane with host endosome membrane, fusion of virus membrane with host plasma membrane, protein autoprocessing, proteolysis, proteolysis involved in protein catabolic process, receptor-mediated endocytosis of virus by host cell, symbiont entry into host cell, zymogen activation; MF: collagen binding, cysteine-type endopeptidase activity, cysteine-type peptidase activity, fibronectin binding, histone binding, hydrolase activity, peptidase activity, proteoglycan binding, serpin family protein binding; CC: Golgi apparatus, extracellular space, lysosome, multivesicular body, plasma membrane
Pathways: Lysosome - Mus musculus (mouse)
UniProt: Q9JL96
Entrez ID: 64139
|
Does Knockout of Ep400 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Ep400
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ep400 (E1A binding protein p400)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, chromatin organization, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair; MF: ATP binding, DNA binding, chromatin binding, helicase activity, hydrolase activity, nucleotide binding, protein antigen binding, protein binding; CC: NuA4 histone acetyltransferase complex, Swr1 complex, nuclear speck, nucleoplasm, nucleosome, nucleus
Pathways: Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, DNA Damage/Telomere Stress Induced Senescence, Formation of Senescence-Associated Heterochromatin Foci (SAHF)
UniProt: Q8CHI8
Entrez ID: 75560
|
Does Knockout of Tor4a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Tor4a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tor4a (torsin family 4, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, ATP hydrolysis activity, molecular_function, nucleotide binding; CC: cytoplasm, endomembrane system, endoplasmic reticulum lumen, membrane, nuclear envelope
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: Q8BH02
Entrez ID: 227612
|
Does Knockout of Lnpep in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Lnpep
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Lnpep (leucyl/cystinyl aminopeptidase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cold-induced thermogenesis, neuropeptide catabolic process, peptide catabolic process, positive regulation of blood pressure, protein catabolic process, proteolysis, regulation of blood pressure, regulation of long-term neuronal synaptic plasticity, response to hormone; MF: aminopeptidase activity, hydrolase activity, metal ion binding, metalloaminopeptidase activity, metallopeptidase activity, peptidase activity, protein binding, zinc ion binding; CC: cell surface, cytoplasmic vesicle, cytoplasmic vesicle membrane, endomembrane system, insulin-responsive compartment, membrane, neuronal cell body, perinuclear region of cytoplasm, plasma membrane, vesicle
Pathways: Adaptive Immune System, Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Endosomal/Vacuolar pathway, Immune System, Renin-angiotensin system - Mus musculus (mouse)
UniProt: Q8C129
Entrez ID: 240028
|
Does Knockout of Epm2a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Epm2a
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Epm2a (epilepsy, progressive myoclonic epilepsy, type 2 gene alpha)
Type: protein-coding
Summary: Enables several functions, including alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity; phosphatase activity; and starch binding activity. Involved in carbohydrate phosphorylation and glycogen biosynthetic process. Acts upstream of or within several processes, including habituation; regulation of protein localization; and regulation of protein metabolic process. Located in several cellular components, including cytoplasmic side of endoplasmic reticulum membrane; dendrite; and perikaryon. Is active in cytosol. Is expressed in several structures, including brain. Used to study Lafora disease and lymphoma. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy. Orthologous to human EPM2A (EPM2A glucan phosphatase, laforin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: L-glutamate transmembrane transport, Wnt signaling pathway, autophagosome assembly, autophagy, calcium ion transport, carbohydrate phosphorylation, glial cell proliferation, glycogen biosynthetic process, glycogen metabolic process, habituation, mitochondrion organization, negative regulation of TOR signaling, negative regulation of cell cycle, negative regulation of dephosphorylation, negative regulation of gene expression, negative regulation of metabolic process, nervous system development, phosphate-containing compound metabolic process, positive regulation of macroautophagy, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of cell growth, regulation of gene expression, regulation of proteasomal protein catabolic process, regulation of protein import into nucleus, regulation of protein localization to plasma membrane, regulation of protein ubiquitination; MF: carbohydrate binding, carbohydrate phosphatase activity, glycogen binding, hydrolase activity, identical protein binding, phosphatase activity, phosphoprotein phosphatase activity, polysaccharide binding, protein binding, protein dimerization activity, protein homodimerization activity, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity, starch binding; CC: cytoplasm, cytoplasmic side of endoplasmic reticulum membrane, cytoplasmic side of rough endoplasmic reticulum membrane, cytosol, dendrite, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleoplasm, nucleus, perikaryon, plasma membrane
Pathways:
UniProt: Q9WUA5
Entrez ID: 13853
|
Does Knockout of Itpkb in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Itpkb
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Itpkb (inositol 1,4,5-trisphosphate 3-kinase B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, T cell differentiation, cell surface receptor signaling pathway, cellular response to calcium ion, common myeloid progenitor cell proliferation, inositol phosphate biosynthetic process, inositol trisphosphate metabolic process, myeloid cell homeostasis, negative regulation of myeloid cell differentiation, negative regulation of neutrophil apoptotic process, phosphatidylinositol phosphate biosynthetic process, positive regulation of Ras protein signal transduction, positive regulation of alpha-beta T cell differentiation, positive thymic T cell selection, thymic T cell selection; MF: ATP binding, calmodulin binding, inositol hexakisphosphate kinase activity, inositol-1,4,5-trisphosphate 3-kinase activity, kinase activity, metal ion binding, nucleotide binding, transferase activity; CC: cytoplasm, cytoskeleton, cytosol, endoplasmic reticulum, membrane, nucleus
Pathways: 1D-<i>myo</i>-inositol hexakisphosphate biosynthesis II (mammalian), Calcium signaling pathway - Mus musculus (mouse), D-<i>myo</i>-inositol (1,3,4)-trisphosphate biosynthesis, Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Synthesis of IP3 and IP4 in the cytosol, superpathway of D-<i>myo</i>-inositol (1,4,5)-trisphosphate metabolism
UniProt: B2RXC2
Entrez ID: 320404
|
Does Knockout of C1qtnf7 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
C1qtnf7
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: C1qtnf7 (C1q and tumor necrosis factor related protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, protein binding; CC: collagen trimer, extracellular region, extracellular space
Pathways:
UniProt: Q8BVD7
Entrez ID: 109323
|
Does Knockout of Anxa7 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Anxa7
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Anxa7 (annexin A7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, establishment of localization in cell, glial cell proliferation, hemostasis, intracellular calcium ion homeostasis, intracellular water homeostasis, ligand-gated ion channel signaling pathway, membrane fusion, negative regulation of gene expression, phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway, positive regulation of insulin secretion, regulation of cell shape, response to calcium ion, response to phorbol 13-acetate 12-myristate, response to salt stress; MF: GTPase-dependent fusogenic activity, calcium ion binding, calcium-dependent phospholipid binding, calcium-dependent protein binding, integrin binding, phosphatidylserine binding, protein binding; CC: chromaffin granule membrane, cytoplasm, cytosol, endoplasmic reticulum membrane, extracellular matrix, nuclear envelope, nucleus, plasma membrane, synapse, vesicle, vesicle membrane
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse)
UniProt: Q07076
Entrez ID: 11750
|
Does Knockout of Cct8l1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Cct8l1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cct8l1 (chaperonin containing TCP1 subunit 8-like 1)
Type: protein-coding
Summary: Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be part of chaperonin-containing T-complex. Orthologous to human CCT8L1P (chaperonin containing TCP1 subunit 8 like 1, pseudogene) and CCT8L2 (chaperonin containing TCP1 subunit 8 like 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: protein folding; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, nucleotide binding, unfolded protein binding
Pathways:
UniProt: Q80YT3
Entrez ID: 242891
|
Does Knockout of Rnf166 in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Rnf166
|
response to virus
|
Microglial Cell Line
|
Gene: Rnf166 (ring finger protein 166)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, immune system process, innate immune response, protein polyubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: metal ion binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding
Pathways:
UniProt: Q3U9F6
Entrez ID: 68718
|
Does Knockout of Ccdc146 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Ccdc146
|
cell cycle progression
|
breast epithelium
|
Gene: Ccdc146 (coiled-coil domain containing 146)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell differentiation, cell morphogenesis, cell population proliferation, cilium organization, flagellated sperm motility, gene expression, manchette assembly, nucleus organization, single fertilization, sperm axoneme assembly, sperm flagellum assembly, spermatid development, spermatogenesis; MF: molecular_function, protein binding, protein-containing complex binding; CC: axoneme, cell projection, centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, midbody, motile cilium, sperm flagellum, sperm head-tail coupling apparatus
Pathways:
UniProt: E9Q9F7
Entrez ID: 75172
|
Does Knockout of Klk1b3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Klk1b3
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Klk1b3 (kallikrein 1-related peptidase b3)
Type: protein-coding
Summary: This gene encodes the gamma subunit of the 7S nerve growth factor (NGF) complex that is essential for the differentiation and survival of distinct populations of neurons in both the central and the peripheral nervous systems. The encoded protein is a glandular kallikrein-type serine protease that processes the beta subunit of NGF. This gene is present in a cluster of multiple related kallikrein-type protease genes on chromosome 7. [provided by RefSeq, Jul 2015].
Gene Ontology: BP: proteolysis, regulation of systemic arterial blood pressure, signal transduction, zymogen activation; MF: endopeptidase activity, growth factor activity, hydrolase activity, metal ion binding, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: acrosomal vesicle, apical part of cell, extracellular space, nucleus, secretory granule
Pathways: Activation of Matrix Metalloproteinases, Degradation of the extracellular matrix, Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Extracellular matrix organization, Renin-angiotensin system - Mus musculus (mouse)
UniProt: P00756
Entrez ID: 18050
|
Does Knockout of Atp10a in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Atp10a
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Atp10a (ATPase, class V, type 10A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid transport, phospholipid translocation, phospholipid transport, positive regulation of membrane tubulation; MF: ATP binding, ATP hydrolysis activity, ATPase-coupled intramembrane lipid transporter activity, glycosylceramide flippase activity, magnesium ion binding, metal ion binding, nucleotide binding, phosphatidylcholine flippase activity, phosphatidylcholine floppase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, phospholipid-translocating ATPase complex, plasma membrane
Pathways: Ion channel transport, Ion transport by P-type ATPases, Transport of small molecules
UniProt: O54827
Entrez ID: 11982
|
Does Knockout of Arl4a in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Arl4a
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Arl4a (ADP-ribosylation factor-like 4A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brown fat cell differentiation, intracellular protein transport, vesicle-mediated transport; MF: GTP binding, GTPase activity, nucleotide binding; CC: cytoplasm, cytosol, membrane, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: P61213
Entrez ID: 11861
|
Does Knockout of Tnfsf12 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Tnfsf12
|
response to virus
|
Microglial Cell Line
|
Gene: Tnfsf12 (tumor necrosis factor (ligand) superfamily, member 12)
Type: protein-coding
Summary: Predicted to enable receptor ligand activity. Acts upstream of or within extrinsic apoptotic signaling pathway. Located in extracellular region. Is expressed in Meckel's cartilage; limb; skeleton; and superior cervical ganglion. Orthologous to several human genes including TNFSF12 (TNF superfamily member 12). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: angiogenesis, apoptotic process, cell differentiation, extrinsic apoptotic signaling pathway, immune response, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of protein catabolic process, signal transduction; MF: cytokine activity, tumor necrosis factor receptor binding; CC: extracellular region, extracellular space, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway, TNFR2 non-canonical NF-kB pathway
UniProt: O54907
Entrez ID: 21944
|
Does Knockout of Vtcn1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Vtcn1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Vtcn1 (V-set domain containing T cell activation inhibitor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell receptor signaling pathway, adaptive immune response, immune system process, negative regulation of T cell activation, negative regulation of T cell proliferation, negative regulation of apoptotic process, positive regulation of T cell proliferation, positive regulation of interleukin-2 production, regulation of T cell proliferation, regulation of cytokine production, response to protozoan; MF: signaling receptor binding; CC: external side of plasma membrane, membrane, plasma membrane, side of membrane
Pathways: Cell adhesion molecules - Mus musculus (mouse)
UniProt: Q7TSP5
Entrez ID: 242122
|
Does Knockout of Mertk in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Mertk
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Mertk (MER proto-oncogene tyrosine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic cell clearance, cell migration, cell surface receptor protein tyrosine kinase signaling pathway, establishment of localization in cell, gamete generation, natural killer cell differentiation, negative regulation of cytokine production, negative regulation of leukocyte apoptotic process, negative regulation of lymphocyte activation, nervous system development, neutrophil clearance, phagocytosis, platelet activation, positive regulation of phagocytosis, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, retina development in camera-type eye, secretion by cell, spermatogenesis, substrate adhesion-dependent cell spreading, vagina development; MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein tyrosine kinase activity, transferase activity, transmembrane receptor protein tyrosine kinase activity; CC: cytoplasm, extracellular space, membrane, photoreceptor outer segment, plasma membrane, receptor complex
Pathways: Cell surface interactions at the vascular wall, Hemostasis
UniProt: Q60805
Entrez ID: 17289
|
Does Knockout of Fbn2 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Fbn2
|
cell proliferation
|
Regulatory T cell
|
Gene: Fbn2 (fibrillin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, bone trabecula formation, camera-type eye development, embryonic eye morphogenesis, embryonic limb morphogenesis, embryonic morphogenesis, glucose homeostasis, glucose metabolic process, limb morphogenesis, placenta development, positive regulation of bone mineralization, positive regulation of osteoblast differentiation, regulation of trophoblast cell migration, sequestering of TGFbeta in extracellular matrix, signal transduction, system development; MF: calcium ion binding, extracellular matrix structural constituent, hormone activity, protein binding; CC: extracellular matrix, extracellular region, extracellular space, microfibril
Pathways: Degradation of the extracellular matrix, Elastic fibre formation, Extracellular matrix organization, Molecules associated with elastic fibres
UniProt: Q61555
Entrez ID: 14119
|
Does Knockout of Cetn4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Cetn4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cetn4 (centrin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: centriole replication, microtubule cytoskeleton organization; MF: G-protein beta/gamma-subunit complex binding, calcium ion binding, heterotrimeric G-protein binding, metal ion binding; CC: centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, microtubule organizing center, nucleus
Pathways:
UniProt: Q8K4K1
Entrez ID: 207175
|
Does Knockout of Tmem196 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Tmem196
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tmem196 (transmembrane protein 196)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: D3YWQ9
Entrez ID: 217951
|
Does Knockout of Ggh in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Ggh
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ggh (gamma-glutamyl hydrolase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: response to ethanol, response to insulin, response to xenobiotic stimulus, response to zinc ion, tetrahydrofolylpolyglutamate metabolic process; MF: gamma-glutamyl-peptidase activity, hydrolase activity, omega peptidase activity; CC: extracellular region, extracellular space, lysosome, melanosome, vacuole
Pathways: Folate biosynthesis - Mus musculus (mouse), Immune System, Innate Immune System, Neutrophil degranulation, glutamate removal from folates, glutathione-mediated detoxification
UniProt: Q9Z0L8
Entrez ID: 14590
|
Does Knockout of Zfp934 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Zfp934
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Zfp934 (zinc finger protein 934)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: fibrillar center, microtubule cytoskeleton, nucleus
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins
UniProt: K7N6H3, A0A1Y7VKB4, A0A1Y7VJM8, Q8BSR1, A0A1Y7VM11, A0A1Y7VMB8, A0A1Y7VN06
Entrez ID: 77117
|
Does Knockout of Fam184a in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Fam184a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Fam184a (family with sequence similarity 184, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: P-body, centriolar satellite, ciliary basal body, cytosol
Pathways:
UniProt: E9QAL2, E9PW83, F6R487, A0A1W2P7N4, A0A1W2P6N4, F6ZCT9, F6RSY8, A0A1W2P6K1, F6TU77, A0A1W2P7W6
Entrez ID: 75906
|
Does Knockout of Tubg1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Tubg1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tubg1 (tubulin, gamma 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic microtubule organization, meiotic spindle organization, microtubule nucleation, microtubule-based process, mitotic cell cycle, mitotic sister chromatid segregation, mitotic spindle organization, regulation of mitotic nuclear division; MF: GTP binding, identical protein binding, microtubule nucleator activity, nucleotide binding, protein binding, structural constituent of cytoskeleton; CC: apical part of cell, cell leading edge, centriole, centrosome, ciliary basal body, cilium, condensed nuclear chromosome, cytoplasm, cytoplasmic microtubule, cytoskeleton, gamma-tubulin complex, gamma-tubulin ring complex, microtubule, microtubule organizing center, mitotic spindle microtubule, neuron projection, non-motile cilium, nucleus, pericentriolar material, polar microtubule, recycling endosome, spindle, spindle microtubule, spindle pole
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Human papillomavirus infection - Mus musculus (mouse), Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: P83887
Entrez ID: 103733
|
Does Knockout of Tmprss13 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Tmprss13
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tmprss13 (transmembrane protease, serine 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment of skin barrier, proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: cytoplasm, extracellular region, membrane, plasma membrane
Pathways:
UniProt: E9QPR6
Entrez ID: 214531
|
Does Knockout of Aspa in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Aspa
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Aspa (aspartoacylase)
Type: protein-coding
Summary: This gene encodes an enzyme that deacteylates N-acetyl-L-aspartic acid (NAA) in the brain to yield acetate and L-aspartate. In humans, alterations in neuronal NAA concentration are associated with many neurodegenerative diseases (decrease associated with epilepsy, multiple sclerosis, myotrophic lateral sclerosis, and Alzheimer's disease; increase associated with Canavan disease). In mouse, mutations in this gene, which cause accumulation of NAA, result in demyelination and spongy degeneration in the CNS and serve as a pathophysiological model for Canavan disease. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: acetate metabolic process, aspartate metabolic process, positive regulation of oligodendrocyte differentiation; MF: aminoacylase activity, aspartoacylase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, hydrolase activity, acting on ester bonds, identical protein binding, metal ion binding, protein binding; CC: cytoplasm, cytosol, nucleus
Pathways: Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Aspartate and asparagine metabolism, Histidine metabolism - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives
UniProt: Q8R3P0
Entrez ID: 11484
|
Does Knockout of Ctu2 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Ctu2
|
response to bacteria
|
renal medulla cell line
|
Gene: Ctu2 (cytosolic thiouridylase subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein urmylation, tRNA processing, tRNA thio-modification, tRNA wobble position uridine thiolation, tRNA wobble uridine modification; MF: nucleotidyltransferase activity, sulfurtransferase activity, tRNA binding; CC: cytoplasm, cytosol, protein-containing complex
Pathways: Sulfur relay system - Mus musculus (mouse)
UniProt: Q3U308
Entrez ID: 66965
|
Does Knockout of Tekt5 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Tekt5
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Tekt5 (tektin 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cilium assembly, cilium movement involved in cell motility, flagellated sperm motility; CC: axonemal A tubule inner sheath, cell projection, cilium, cytoplasm, cytoskeleton, microtubule cytoskeleton, motile cilium, sperm flagellum
Pathways:
UniProt: G5E8A8
Entrez ID: 70426
|
Does Knockout of Foxd3 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Foxd3
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Foxd3 (forkhead box D3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, anatomical structure morphogenesis, cell differentiation, cellular response to leukemia inhibitory factor, embryonic placenta development, in utero embryonic development, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, trophectodermal cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, double-stranded DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: chromatin, nucleus, transcription regulator complex
Pathways:
UniProt: Q61060
Entrez ID: 15221
|
Does Knockout of Ccs in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Ccs
|
cell proliferation
|
Regulatory T cell
|
Gene: Ccs (copper chaperone for superoxide dismutase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: removal of superoxide radicals, superoxide metabolic process; MF: copper ion binding, enzyme binding, metal ion binding, superoxide dismutase copper chaperone activity; CC: cytoplasm, mitochondrial intermembrane space, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Detoxification of Reactive Oxygen Species, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse)
UniProt: Q9WU84
Entrez ID: 12460
|
Does Knockout of Unc79 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Unc79
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Unc79 (unc-79 homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult behavior, behavioral response to ethanol, multicellular organism growth, suckling behavior; CC: membrane, plasma membrane
Pathways: Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q0KK59
Entrez ID: 217843
|
Does Knockout of Samm50 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Samm50
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Samm50 (SAMM50 sorting and assembly machinery component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cristae formation, protein import into mitochondrial matrix, protein insertion into mitochondrial outer membrane; CC: SAM complex, cytoplasm, membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrion, outer membrane
Pathways: RAC2 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8BGH2
Entrez ID: 68653
|
Does Knockout of 2410002F23Rik in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
2410002F23Rik
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: 2410002F23Rik (RIKEN cDNA 2410002F23 gene)
Type: protein-coding
Summary: Predicted to be involved in response to virus. Predicted to be active in Golgi apparatus. Is expressed in central nervous system and retina. Orthologous to human C19orf48P (chromosome 19 open reading frame 48, pseudogene). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, response to virus; CC: Golgi apparatus, cellular_component
Pathways:
UniProt: Q9CWW9, Q3TE80, A0A087WSJ7, A0A087WPT9, D3Z7R5, D3Z276, D3Z520, A0A087WQ29
Entrez ID: 668661
|
Does Knockout of Tas2r135 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Tas2r135
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Tas2r135 (taste receptor, type 2, member 135)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sensory perception of taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity, taste receptor activity; CC: membrane
Pathways: Class C/3 (Metabotropic glutamate/pheromone receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Signal Transduction, Signaling by GPCR, Taste transduction - Mus musculus (mouse)
UniProt: Q7TQA9
Entrez ID: 387512
|
Does Knockout of Mgst1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Mgst1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Mgst1 (microsomal glutathione S-transferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to lipid hydroperoxide, glutathione metabolic process, glutathione transport, response to lipopolysaccharide, response to xenobiotic stimulus; MF: glutathione binding, glutathione peroxidase activity, glutathione transferase activity, identical protein binding, transferase activity; CC: apical part of cell, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrion, peroxisomal membrane
Pathways: Aflatoxin activation and detoxification, Biological oxidations, Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Drug metabolism - cytochrome P450 - Mus musculus (mouse), Drug metabolism - other enzymes - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Glutathione conjugation, Glutathione metabolism - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Immune System, Innate Immune System, Metabolism, Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Neutrophil degranulation, Pathways in cancer - Mus musculus (mouse), Phase II - Conjugation of compounds, glutathione-mediated detoxification
UniProt: Q91VS7
Entrez ID: 56615
|
Does Knockout of Sumo3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Sumo3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Sumo3 (small ubiquitin-like modifier 3)
Type: protein-coding
Summary: This gene encodes a member of the small ubiquitin-like modifier family. The encoded protein may regulate a variety of proteins in many pathways via a post-translational modification, known as SUMOylation. This activity may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Disruption of some of these processes has been associated with cerebral ischemia, neural dysfunction, and heart disease. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014].
Gene Ontology: BP: positive regulation of ubiquitin-dependent protein catabolic process, protein localization to nucleus, protein sumoylation, regulation of protein localization to nucleus; MF: SUMO transferase activity, protein tag activity, ubiquitin-like protein ligase binding; CC: PML body, cytoplasm, glutamatergic synapse, nuclear body, nucleoplasm, nucleus, postsynaptic cytosol, presynaptic cytosol
Pathways: DNA Repair, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Formation of Incision Complex in GG-NER, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of proteins, Nucleocytoplasmic transport - Mus musculus (mouse), Nucleotide Excision Repair, Post-translational protein modification, Processing and activation of SUMO, SUMO E3 ligases SUMOylate target proteins, SUMO is proteolytically processed, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of chromatin organization proteins, SUMOylation of immune response proteins, SUMOylation of intracellular receptors, SUMOylation of transcription cofactors, SUMOylation of transcription factors
UniProt: Q9Z172
Entrez ID: 20610
|
Does Knockout of Copz1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Copz1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Copz1 (coatomer protein complex, subunit zeta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intra-Golgi vesicle-mediated transport, intracellular protein transport, protein transport, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle-mediated transport; CC: COPI vesicle coat, COPI-coated vesicle membrane, Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, membrane, membrane coat
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: P61924
Entrez ID: 56447
|
Does Knockout of Ctnnb1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Ctnnb1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ctnnb1 (catenin beta 1)
Type: protein-coding
Summary: This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth and differentiation during both normal development and tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins; meanwhile, it also binds alpha-catenin, which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Another key function of this protein is to mediate the canonical Wnt signaling pathway and regulate gene transcription. Without Wnt signal, cytoplasmic beta-catenin that is not associated with the cadherin complex is quickly phosphorylated at the N-terminal Ser/Thr residues by the so called degradation complex containing axin, adenomatous polyposis coli (APC), casein kinase I, and GSK3B, then ubiquitylated by beta-TrCP, and degraded by the proteasome. However, in the presence of Wnt signal, the degradation complex is disrupted and the stabilized cytoplasmic beta-catenin translocates into the nucleus, where it binds various transcription factors and, together with these factors, regulates the transcription of many downstream genes. Mutations of this gene have been linked with various types of tumors. Alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: Schwann cell proliferation, T cell differentiation, T cell differentiation in thymus, Wnt signaling pathway, acinar cell differentiation, adherens junction assembly, adherens junction organization, angiogenesis, animal organ development, anterior/posterior axis specification, astrocyte-dopaminergic neuron signaling, bone resorption, branching involved in blood vessel morphogenesis, branching involved in ureteric bud morphogenesis, canonical Wnt signaling pathway, canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation, cardiac muscle cell proliferation, cardiac vascular smooth muscle cell differentiation, cell adhesion, cell fate specification, cell maturation, cell morphogenesis, cell population proliferation, cell-cell adhesion, cell-cell adhesion mediated by cadherin, cell-cell junction organization, cell-matrix adhesion, cellular response to growth factor stimulus, cellular response to indole-3-methanol, cellular response to insulin-like growth factor stimulus, cellular response to mechanical stimulus, central nervous system vasculogenesis, chemical synaptic transmission, coronary artery morphogenesis, cranial ganglion development, cranial skeletal system development, cytokine-mediated signaling pathway, dorsal root ganglion development, dorsal/ventral axis specification, dorsal/ventral pattern formation, ectoderm development, embryonic axis specification, embryonic brain development, embryonic digit morphogenesis, embryonic foregut morphogenesis, embryonic forelimb morphogenesis, embryonic heart tube development, embryonic hindlimb morphogenesis, embryonic organ development, embryonic skeletal limb joint morphogenesis, endoderm formation, endodermal cell fate commitment, endothelial tube morphogenesis, epicardium-derived cardiac vascular smooth muscle cell differentiation, epidermal growth factor receptor signaling pathway, epithelial cell development, epithelial cell differentiation, epithelial cell differentiation involved in prostate gland development, epithelial tube branching involved in lung morphogenesis, establishment of blood-brain barrier, establishment of blood-retinal barrier, forebrain development, fungiform papilla formation, gastrulation with mouth forming second, gene expression, genitalia morphogenesis, glial cell fate determination, hair cycle process, hair follicle morphogenesis, hair follicle placode formation, heart development, hemopoiesis, hindbrain development, hypothalamus development, in utero embryonic development, intracellular protein localization, kidney development, layer formation in cerebral cortex, lens morphogenesis in camera-type eye, limb development, lung cell differentiation, lung development, lung epithelial cell differentiation, lung induction, lung-associated mesenchyme development, male genitalia development, mesenchymal cell proliferation involved in lung development, mesenchymal stem cell differentiation, mesenchymal to epithelial transition, mesenchyme development, mesenchyme morphogenesis, metanephros morphogenesis, midbrain development, midbrain dopaminergic neuron differentiation, morphogenesis of embryonic epithelium, myoblast proliferation, negative regulation of DNA-templated transcription, negative regulation of angiogenesis, negative regulation of apoptotic process, negative regulation of apoptotic signaling pathway, negative regulation of canonical Wnt signaling pathway, negative regulation of cell differentiation, negative regulation of cell population proliferation, negative regulation of chondrocyte differentiation, negative regulation of gene expression, negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis, negative regulation of mitotic cell cycle, embryonic, negative regulation of neurogenesis, negative regulation of neuron apoptotic process, negative regulation of oligodendrocyte differentiation, negative regulation of osteoclast differentiation, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, negative regulation of protein sumoylation, negative regulation of transcription by RNA polymerase II, nephron tubule formation, nervous system development, neural plate development, neuron differentiation, neuron fate determination, neuron migration, neuron projection extension, odontogenesis of dentin-containing tooth, oocyte development, osteoblast differentiation, osteoclast differentiation, outflow tract morphogenesis, oviduct development, pancreas development, positive regulation of DNA-templated transcription, positive regulation of MAPK cascade, positive regulation of apoptotic process, positive regulation of blood vessel branching, positive regulation of branching involved in lung morphogenesis, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell differentiation, positive regulation of cell population proliferation, positive regulation of determination of dorsal identity, positive regulation of endothelial cell differentiation, positive regulation of epithelial cell differentiation, positive regulation of epithelial cell proliferation involved in prostate gland development, positive regulation of epithelial to mesenchymal transition, positive regulation of fibroblast growth factor receptor signaling pathway, positive regulation of gene expression, positive regulation of heparan sulfate proteoglycan biosynthetic process, positive regulation of homotypic cell-cell adhesion, positive regulation of mesenchymal cell proliferation, positive regulation of myoblast proliferation, positive regulation of neural precursor cell proliferation, positive regulation of neuroblast proliferation, positive regulation of neuron apoptotic process, positive regulation of odontoblast differentiation, positive regulation of osteoblast differentiation, positive regulation of skeletal muscle tissue development, positive regulation of stem cell proliferation, positive regulation of telomere maintenance via telomerase, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein localization to cell surface, protein polyubiquitination, proximal/distal pattern formation, regulation of T cell proliferation, regulation of apoptotic process, regulation of calcium ion import, regulation of cell differentiation, regulation of cell population proliferation, regulation of centriole-centriole cohesion, regulation of centromeric sister chromatid cohesion, regulation of epithelial cell differentiation, regulation of epithelial to mesenchymal transition, regulation of gene expression, regulation of myelination, regulation of nephron tubule epithelial cell differentiation, regulation of neurogenesis, regulation of osteoblast differentiation, regulation of osteoclast differentiation, regulation of protein localization to cell surface, regulation of protein ubiquitination, regulation of secondary heart field cardioblast proliferation, regulation of smooth muscle cell proliferation, regulation of synapse assembly, regulation of timing of anagen, regulation of transcription by RNA polymerase II, renal inner medulla development, renal outer medulla development, renal vesicle formation, response to cytokine, response to estradiol, response to estrogen, response to xenobiotic stimulus, skeletal system development, skin development, smooth muscle cell differentiation, sympathetic ganglion development, synapse organization, synaptic vesicle clustering, synaptic vesicle transport, thymus development, tissue homeostasis, trachea formation, trachea morphogenesis, vasculature development, vasculogenesis, ventricular compact myocardium morphogenesis; MF: DNA-binding transcription factor binding, I-SMAD binding, RNA polymerase II-specific DNA-binding transcription factor binding, SMAD binding, alpha-catenin binding, cadherin binding, chromatin binding, delta-catenin binding, disordered domain specific binding, enzyme binding, histone methyltransferase binding, ionotropic glutamate receptor binding, kinase binding, molecular function activator activity, nitric-oxide synthase binding, nuclear estrogen receptor binding, nuclear receptor binding, nucleic acid binding, phosphatase binding, protein binding, protein kinase binding, protein phosphatase binding, protein-containing complex binding, signaling receptor binding, transcription coactivator activity, transcription coregulator binding, transcription corepressor binding, transmembrane transporter binding, ubiquitin protein ligase binding; CC: RNA polymerase II transcription regulator complex, Schaffer collateral - CA1 synapse, Scrib-APC-beta-catenin complex, Wnt signalosome, Z disc, adherens junction, anchoring junction, apical junction complex, apical part of cell, apical plasma membrane, apicolateral plasma membrane, basolateral plasma membrane, beta-catenin destruction complex, beta-catenin-ICAT complex, beta-catenin-TCF complex, beta-catenin-TCF7L2 complex, bicellular tight junction, catenin complex, cell cortex, cell junction, cell periphery, cell projection, cell projection membrane, cell-cell junction, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, dendritic shaft, euchromatin, fascia adherens, flotillin complex, glutamatergic synapse, intercalated disc, lamellipodium, lateral plasma membrane, membrane, microvillus membrane, nuclear membrane, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, postsynaptic density, intracellular component, postsynaptic membrane, presynaptic active zone cytoplasmic component, presynaptic membrane, protein-DNA complex, protein-containing complex, spindle pole, synapse, tight junction, transcription regulator complex
Pathways: Adherens junction - Mus musculus (mouse), Adherens junctions interactions, Alcoholic liver disease - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Apoptosis, Apoptotic cleavage of cell adhesion proteins, Apoptotic cleavage of cellular proteins, Apoptotic execution phase, Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Bacterial invasion of epithelial cells - Mus musculus (mouse), Basal cell carcinoma - Mus musculus (mouse), Beta-catenin independent WNT signaling, Beta-catenin phosphorylation cascade, Breast cancer - Mus musculus (mouse), Ca2+ pathway, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Colorectal cancer - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Cytosolic sensors of pathogen-associated DNA , Deactivation of the beta-catenin transactivating complex, Degradation of CDH1, Degradation of beta-catenin by the destruction complex, Developmental Biology, Disassembly of the destruction complex and recruitment of AXIN to the membrane, Endometrial cancer - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Formation of the beta-catenin:TCF transactivating complex, Gastric cancer - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production, Leukocyte transendothelial migration - Mus musculus (mouse), MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Melanogenesis - Mus musculus (mouse), Myogenesis, Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Programmed Cell Death, Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases activate IQGAPs, RNA Polymerase II Transcription, RUNX3 regulates WNT signaling, Rap1 signaling pathway - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of CDH11 Expression and Function, Regulation of CDH11 function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Expression and Function of Type II Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of MITF-M-dependent genes involved in cell cycle and proliferation, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TCF dependent signaling in response to WNT, Thyroid cancer - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Transcriptional regulation by RUNX3, VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q02248
Entrez ID: 12387
|
Does Knockout of Errfi1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Errfi1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Errfi1 (ERBB receptor feedback inhibitor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, bile acid biosynthetic process, cartilage development, cell migration, cellular hyperosmotic response, cellular response to dexamethasone stimulus, cellular response to epidermal growth factor stimulus, cellular response to insulin stimulus, cellular response to platelet-derived growth factor stimulus, cholesterol homeostasis, cholesterol metabolic process, chondrocyte proliferation, embryo implantation, epidermal growth factor receptor signaling pathway, epithelial cell proliferation, epithelium development, fat pad development, gene expression, glucose metabolic process, limb joint morphogenesis, lipid metabolic process, liver development, lung alveolus development, lung epithelium development, lung vasculature development, negative regulation of ERK1 and ERK2 cascade, negative regulation of cardiac muscle hypertrophy in response to stress, negative regulation of collagen biosynthetic process, negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of epidermal growth factor-activated receptor activity, negative regulation of interleukin-1 beta production, negative regulation of peptidyl-tyrosine phosphorylation, negative regulation of protein autophosphorylation, negative regulation of tumor necrosis factor production, phosphatidylinositol 3-kinase/protein kinase B signal transduction, progesterone receptor signaling pathway, protein localization to plasma membrane, regulation of keratinocyte differentiation, regulation of type B pancreatic cell proliferation, response to 1-oleoyl-sn-glycerol 3-phosphate, response to estradiol, response to insulin, response to progesterone, response to steroid hormone, response to xenobiotic stimulus, skeletal system development, skin development, skin morphogenesis, stress-activated protein kinase signaling cascade, tissue homeostasis, uterine epithelium development, uterus development; MF: SH3 domain binding, kinase binding, protein binding, protein kinase binding, small GTPase binding; CC: cytoplasm, cytosol, membrane, nucleus, plasma membrane
Pathways:
UniProt: Q99JZ7
Entrez ID: 74155
|
Does Knockout of Clpb in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Clpb
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Clpb (ClpB caseinolytic peptidase B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RIG-I signaling pathway, antiviral innate immune response, cellular response to heat, granulocyte differentiation; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein disaggregase activity, hydrolase activity, nucleotide binding; CC: cytoplasm, mitochondrial intermembrane space, mitochondrion
Pathways: Longevity regulating pathway - multiple species - Mus musculus (mouse)
UniProt: Q60649
Entrez ID: 20480
|
Does Knockout of Arglu1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,259
|
Knockout
|
Arglu1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Arglu1 (arginine and glutamate rich 1)
Type: protein-coding
Summary: Enables pre-mRNA binding activity and transcription coactivator activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and leg muscle. Orthologous to human ARGLU1 (arginine and glutamate rich 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, mRNA processing, positive regulation of DNA-templated transcription, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, pre-mRNA binding, transcription coactivator activity; CC: chromosome, cytosol, mitochondrion, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q3UL36
Entrez ID: 234023
|
Does Knockout of Tmem67 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Tmem67
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Tmem67 (transmembrane protein 67)
Type: protein-coding
Summary: Predicted to enable filamin binding activity; misfolded protein binding activity; and unfolded protein binding activity. Involved in several processes, including epithelial tube branching involved in lung morphogenesis; negative regulation of centrosome duplication; and non-canonical Wnt signaling pathway. Acts upstream of or within determination of left/right symmetry; heart development; and kidney development. Located in cytoplasmic vesicle membrane and endoplasmic reticulum membrane. Part of MKS complex. Is expressed in diencephalon; hindbrain lateral wall; metanephros; and organ of Corti. Used to study Joubert syndrome 6; Meckel syndrome; cystic kidney disease; and visceral heterotaxy. Human ortholog(s) of this gene implicated in several diseases, including Bardet-Biedl syndrome (multiple); COACH syndrome; Joubert syndrome 6; Meckel syndrome 3; and nephronophthisis (multiple). Orthologous to human TMEM67 (transmembrane protein 67). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: ERAD pathway, branching morphogenesis of an epithelial tube, cell projection organization, cilium assembly, determination of left/right symmetry, epithelial tube branching involved in lung morphogenesis, head development, heart development, kidney development, negative regulation of centrosome duplication, non-canonical Wnt signaling pathway, photoreceptor cell outer segment organization, positive regulation of ERAD pathway, positive regulation of non-motile cilium assembly; MF: filamin binding, misfolded protein binding, unfolded protein binding; CC: MKS complex, axoneme, cell projection, centrosome, ciliary membrane, ciliary transition zone, cilium, cytoplasm, cytoplasmic vesicle membrane, cytoskeleton, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways: Anchoring of the basal body to the plasma membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: Q8BR76
Entrez ID: 329795
|
Does Knockout of Spata1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Spata1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Spata1 (spermatogenesis associated 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, protein binding; CC: acrosomal vesicle, cytoplasmic vesicle
Pathways:
UniProt: Q9D5R4
Entrez ID: 70951
|
Does Knockout of Tgds in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,175
|
Knockout
|
Tgds
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Tgds (TDP-glucose 4,6-dehydratase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, nucleotide-sugar metabolic process; MF: catalytic activity, dTDP-glucose 4,6-dehydratase activity, lyase activity, molecular_function
Pathways:
UniProt: Q8VDR7
Entrez ID: 76355
|
Does Knockout of Zc3h12d in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Zc3h12d
|
phagocytosis
|
macrophage
|
Gene: Zc3h12d (zinc finger CCCH type containing 12D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, mRNA catabolic process, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of T cell proliferation, negative regulation of cell growth; MF: RNA endonuclease activity, endonuclease activity, hydrolase activity, mRNA binding, metal ion binding, nuclease activity, zinc ion binding; CC: P-body, cytoplasm, cytoplasmic ribonucleoprotein granule, nucleoplasm, nucleus
Pathways:
UniProt: Q8BIY3
Entrez ID: 237256
|
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