prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Vmn1r201 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Vmn1r201
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Vmn1r201 (vomeronasal 1 receptor 201)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8R262
Entrez ID: 171255
|
Does Knockout of Ush1g in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Ush1g
|
cell cycle progression
|
breast epithelium
|
Gene: Ush1g (USH1 protein network component sans)
Type: protein-coding
Summary: This gene encodes a protein that contains three ankyrin domains, a class I PDZ-binding motif and a sterile alpha motif. The encoded protein interacts with harmonin, which is associated with Usher syndrome type 1C. This protein plays a role in the development and maintenance of the auditory and visual systems and functions in the cohesion of hair bundles formed by inner ear sensory cells. Mutations in this gene are associated with combined auditory and vision loss. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: equilibrioception, inner ear morphogenesis, inner ear receptor cell differentiation, inner ear receptor cell stereocilium organization, photoreceptor cell maintenance, regulation of clathrin-dependent endocytosis, sensory perception of light stimulus, sensory perception of sound; MF: identical protein binding, protein binding, spectrin binding; CC: Cajal body, actin cytoskeleton, cell projection, centrosome, ciliary basal body, ciliary base, cilium, cytoplasm, cytoskeleton, cytosol, membrane, nuclear speck, nucleus, photoreceptor cell cilium, photoreceptor connecting cilium, photoreceptor inner segment, plasma membrane, plasma membrane bounded cell projection
Pathways:
UniProt: Q80T11
Entrez ID: 16470
|
Does Knockout of Aqp9 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Aqp9
|
cell cycle progression
|
breast epithelium
|
Gene: Aqp9 (aquaporin 9)
Type: protein-coding
Summary: This gene encodes a member of the aquaglyceroporin subfamily of aquaporins. This protein transports water, glycerol, urea, purines and pyrimidines and plays a role in glycerol metabolism and osteoclast differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: amine transport, canalicular bile acid transport, cellular response to cAMP, detoxification of arsenic-containing substance, glycerol transmembrane transport, hydrogen peroxide transmembrane transport, polyol transmembrane transport, purine nucleobase transmembrane transport, purine nucleobase transport, pyrimidine nucleobase transport, pyrimidine-containing compound transmembrane transport, response to pain, transmembrane transport, urea transmembrane transport, water transport; MF: channel activity, glycerol channel activity, hydrogen peroxide channel activity, polyol transmembrane transporter activity, purine nucleobase transmembrane transporter activity, pyrimidine nucleobase transmembrane transporter activity, urea channel activity, urea transmembrane transporter activity, water channel activity; CC: basolateral plasma membrane, membrane, plasma membrane
Pathways: Aquaporin-mediated transport, Bile secretion - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Passive transport by Aquaporins, Transport of glycerol from adipocytes to the liver by Aquaporins, Transport of small molecules
UniProt: Q9JJJ3
Entrez ID: 64008
|
Does Knockout of Mgarp in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Mgarp
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mgarp (mitochondria localized glutamic acid rich protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterograde axonal transport, axon development, axonal transport of mitochondrion, cellular response to gonadotropin-releasing hormone, cellular response to hypoxia, cellular response to steroid hormone stimulus, cerebral cortex development, negative regulation of dendrite development, protein targeting to mitochondrion, regulation of mitochondrion organization, retrograde axonal transport; CC: axon cytoplasm, membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrion
Pathways:
UniProt: Q8VI64
Entrez ID: 67749
|
Does Knockout of D430041D05Rik in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
D430041D05Rik
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: D430041D05Rik (RIKEN cDNA D430041D05 gene)
Type: protein-coding
Summary: Is expressed in nervous system; neural retina; thymus; and upper jaw molar. Orthologous to human KIAA1549L (KIAA1549 like). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: A0A2R8VHF1, F6ZGR6, D3YZ21, A0A2R8VKG2
Entrez ID: 241589
|
Does Knockout of Dnm2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Dnm2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Dnm2 (dynamin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor internalization, Golgi to plasma membrane transport, actin filament bundle organization, aorta development, autophagy, cellular response to dopamine, centrosome cycle, coronary vasculature development, endocytosis, macropinocytosis, membrane tubulation, negative regulation of membrane tubulation, negative regulation of non-motile cilium assembly, negative regulation of transforming growth factor beta receptor signaling pathway, neuron projection morphogenesis, phagocytosis, positive regulation of clathrin-dependent endocytosis, positive regulation of endocytosis, positive regulation of lamellipodium assembly, positive regulation of nitric oxide biosynthetic process, positive regulation of phagocytosis, positive regulation of substrate adhesion-dependent cell spreading, postsynaptic endocytosis, protein polymerization, receptor internalization, receptor-mediated endocytosis, regulation of Golgi organization, regulation of Rac protein signal transduction, regulation of axon extension, stress fiber assembly, synaptic vesicle budding from presynaptic endocytic zone membrane, synaptic vesicle endocytosis, transferrin transport, ventricular septum development, vesicle scission; MF: D2 dopamine receptor binding, GTP binding, GTPase activity, SH3 domain binding, WW domain binding, hydrolase activity, microtubule binding, nitric-oxide synthase binding, nucleotide binding, phosphatidylinositol 3-kinase regulatory subunit binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding, protein kinase binding, protein serine/threonine kinase binding, protein-containing complex binding; CC: Golgi apparatus, Golgi membrane, anchoring junction, cell junction, cell projection, centriole, centrosome, clathrin-coated endocytic vesicle, clathrin-coated pit, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, endosome, glutamatergic synapse, growth cone, lamellipodium, membrane, microtubule, midbody, neuron projection, perinuclear region of cytoplasm, phagocytic cup, phagocytic vesicle membrane, photoreceptor inner segment, plasma membrane, podosome, postsynaptic density, postsynaptic density, intracellular component, postsynaptic endocytic zone, postsynaptic membrane, presynapse, protein-containing complex, recycling endosome, ruffle membrane, synapse, trans-Golgi network, uropod
Pathways: Adaptive Immune System, Adherens junctions interactions, Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Clathrin-mediated endocytosis, Degradation of CDH1, Developmental Biology, Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Endocytosis - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Formation of annular gap junctions, Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, Golgi Associated Vesicle Biogenesis, Immune System, Innate Immune System, L1CAM interactions, Lysosome Vesicle Biogenesis, MHC class II antigen presentation, Membrane Trafficking, Metabolism, Metabolism of nitric oxide: NOS3 activation and regulation, NOSTRIN mediated eNOS trafficking, Nervous system development, Phospholipase D signaling pathway - Mus musculus (mouse), Recycling pathway of L1, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Salmonella infection - Mus musculus (mouse), Synaptic vesicle cycle - Mus musculus (mouse), Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades, Vesicle-mediated transport, cyclic AMP biosynthesis, trans-Golgi Network Vesicle Budding
UniProt: P39054
Entrez ID: 13430
|
Does Knockout of Arhgap1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Arhgap1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Arhgap1 (Rho GTPase activating protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endosomal transport, negative regulation of endocytic recycling, signal transduction, small GTPase-mediated signal transduction, transferrin transport; MF: GTPase activator activity, SH3 domain binding, protein binding, small GTPase binding; CC: cell leading edge, cilium, cytoplasm, cytosol, endosome membrane, membrane, perinuclear region of cytoplasm, plasma membrane, plasma membrane bounded cell projection, ruffle, sorting endosome
Pathways: CDC42 GTPase cycle, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, RHOG GTPase cycle, RHOJ GTPase cycle, RHOQ GTPase cycle, RND2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q5FWK3
Entrez ID: 228359
|
Does Knockout of Arhgap25 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Arhgap25
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Arhgap25 (Rho GTPase activating protein 25)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament organization, negative regulation of small GTPase mediated signal transduction, phagocytosis, engulfment, regulation of small GTPase mediated signal transduction, signal transduction; MF: GTPase activator activity; CC: phagocytic cup
Pathways: RAC1 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8BYW1
Entrez ID: 232201
|
Does Knockout of Atg16l1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Atg16l1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Atg16l1 (autophagy related 16 like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagy, axonal transport, corpus callosum development, defense response to virus, dendrite arborization, hippocampus development, macroautophagy, microautophagy, negative regulation of dendrite extension, negative stranded viral RNA replication, positive regulation of autophagy, protein localization to phagophore assembly site, protein transport, xenophagy; MF: GTPase binding, identical protein binding, protein binding, protein-membrane adaptor activity; CC: Atg12-Atg5-Atg16 complex, autophagosome, autophagosome membrane, axon, axoneme, cytoplasm, cytosol, endolysosome membrane, endosome, endosome membrane, glutamatergic synapse, lysosomal membrane, lysosome, membrane, phagophore assembly site membrane, sperm midpiece, synapse, vacuole-isolation membrane contact site
Pathways: Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse)
UniProt: Q8C0J2
Entrez ID: 77040
|
Does Knockout of Pcnx2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Pcnx2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pcnx2 (pecanex homolog 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q5DU28
Entrez ID: 270109
|
Does Knockout of Jak1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Jak1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Jak1 (Janus kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cell surface receptor signaling pathway via JAK-STAT, cellular response to interleukin-3, cellular response to interleukin-7, cytokine-mediated signaling pathway, enzyme-linked receptor protein signaling pathway, growth hormone receptor signaling pathway via JAK-STAT, interleukin-10-mediated signaling pathway, interleukin-11-mediated signaling pathway, interleukin-15-mediated signaling pathway, interleukin-2-mediated signaling pathway, interleukin-4-mediated signaling pathway, interleukin-6-mediated signaling pathway, interleukin-7-mediated signaling pathway, interleukin-9-mediated signaling pathway, intracellular signal transduction, positive regulation of homotypic cell-cell adhesion, positive regulation of protein localization to nucleus, positive regulation of receptor signaling pathway via STAT, positive regulation of sprouting angiogenesis, protein localization to cell-cell junction, regulation of transcription by RNA polymerase II, response to antibiotic, type I interferon-mediated signaling pathway, type II interferon-mediated signaling pathway; MF: ATP binding, CCR5 chemokine receptor binding, growth hormone receptor binding, kinase activity, metal ion binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein binding, protein kinase activity, protein phosphatase binding, protein tyrosine kinase activity, transferase activity, ubiquitin protein ligase binding; CC: cytoplasm, cytoplasmic side of plasma membrane, cytosol, endomembrane system, extrinsic component of cytoplasmic side of plasma membrane, membrane, nucleus, receptor complex
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Influenza A - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q3U8P8, Q3URU8, B1ASP2, B1ASP3
Entrez ID: 16451
|
Does Knockout of Etv1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Etv1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Etv1 (ets variant 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, cell differentiation, mechanosensory behavior, muscle organ development, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: nucleus
Pathways: Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: P41164
Entrez ID: 14009
|
Does Knockout of Kdm6b in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Kdm6b
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Kdm6b (KDM1 lysine (K)-specific demethylase 6B)
Type: protein-coding
Summary: Enables beta-catenin binding activity; histone H3K27me2/H3K27me3 demethylase activity; and sequence-specific DNA binding activity. Involved in several processes, including cardiac muscle cell differentiation; mesodermal cell differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within cell fate commitment; cellular response to hydrogen peroxide; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including 1st branchial arch ectoderm; brain; genitourinary system; olfactory epithelium; and palatal shelf. Human ortholog(s) of this gene implicated in Stolerman neurodevelopmental syndrome. Orthologous to human KDM6B (lysine demethylase 6B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cardiac muscle cell differentiation, cell fate commitment, cellular response to hydrogen peroxide, chromatin organization, chromatin remodeling, endothelial cell differentiation, heart development, hippocampus development, inflammatory response, inflammatory response to antigenic stimulus, mesodermal cell differentiation, positive regulation of cold-induced thermogenesis, positive regulation of transcription by RNA polymerase II, regulation of gene expression, response to activity, response to fungicide; MF: RNA polymerase II cis-regulatory region sequence-specific DNA binding, beta-catenin binding, chromatin DNA binding, chromatin binding, dioxygenase activity, histone H3K27me2/H3K27me3 demethylase activity, metal ion binding, oxidoreductase activity, protein binding, sequence-specific DNA binding; CC: MLL3/4 complex, nucleoplasm, nucleus
Pathways: Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones, Oxidative Stress Induced Senescence
UniProt: Q5NCY0
Entrez ID: 216850
|
Does Knockout of Taf6l in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Taf6l
|
cell proliferation
|
Regulatory T cell
|
Gene: Taf6l (TATA-box binding protein associated factor 6 like)
Type: protein-coding
Summary: Predicted to enable transcription coactivator activity. Involved in regulation of DNA-templated transcription and regulation of somatic stem cell population maintenance. Located in nucleus. Is expressed in tail. Orthologous to human TAF6L (TATA-box binding protein associated factor 6 like). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of somatic stem cell population maintenance, transcription initiation at RNA polymerase II promoter; MF: RNA polymerase II general transcription initiation factor activity, protein heterodimerization activity, transcription coactivator activity; CC: SAGA complex, SLIK (SAGA-like) complex, nucleoplasm, nucleus, transcription factor TFIID complex
Pathways: Basal transcription factors - Mus musculus (mouse)
UniProt: Q8R2K4
Entrez ID: 225895
|
Does Knockout of Cep170 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Cep170
|
response to bacteria
|
renal medulla cell line
|
Gene: Cep170 (centrosomal protein 170)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, protein binding; CC: centriolar subdistal appendage, centriole, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, microtubule, spindle
Pathways:
UniProt: Q6A065
Entrez ID: 545389
|
Does Knockout of Pim2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Pim2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pim2 (proviral integration site 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, apoptotic mitochondrial changes, apoptotic process, negative regulation of apoptotic process, negative regulation of cell population proliferation, positive regulation of DNA-templated transcription, positive regulation of autophagy, positive regulation of canonical NF-kappaB signal transduction, positive regulation of macroautophagy, protein phosphorylation, protein stabilization, regulation of mitotic cell cycle, response to virus; MF: ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse)
UniProt: Q62070
Entrez ID: 18715
|
Does Knockout of Sost in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Sost
|
phagocytosis
|
macrophage
|
Gene: Sost (sclerostin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, cellular response to parathyroid hormone stimulus, negative regulation of BMP signaling pathway, negative regulation of Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, negative regulation of ossification, negative regulation of protein-containing complex assembly, ossification, positive regulation of DNA-templated transcription, response to mechanical stimulus; MF: BMP binding, DNA-binding transcription factor binding, carbohydrate binding, heparin binding, molecular function inhibitor activity, protein binding; CC: Golgi apparatus, extracellular region, extracellular space, protein-containing complex
Pathways: Negative regulation of TCF-dependent signaling by WNT ligand antagonists, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q99P68
Entrez ID: 74499
|
Does Knockout of Mettl2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Mettl2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mettl2 (methyltransferase 2, methylcytidine)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, tRNA methylation, tRNA processing; MF: RNA methyltransferase activity, S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, tRNA (cytidine) methyltransferase activity, tRNA (cytidine-3-)-methyltransferase activity, transferase activity; CC: cytoplasm
Pathways:
UniProt: Q8BMK1
Entrez ID: 52686
|
Does Knockout of Serpina1f in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Serpina1f
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Serpina1f (serine (or cysteine) peptidase inhibitor, clade A, member 1F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: endoplasmic reticulum, extracellular region, extracellular space
Pathways:
UniProt: Q9DCQ7
Entrez ID: 68348
|
Does Knockout of Hsf2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Hsf2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Hsf2 (heat shock factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, spermatogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, identical protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: cytoplasm, nucleoplasm, nucleus
Pathways:
UniProt: P38533
Entrez ID: 15500
|
Does Knockout of Vwa2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Vwa2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Vwa2 (von Willebrand factor A domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium-independent cell-matrix adhesion, regulation of insulin receptor signaling pathway; MF: calcium ion binding, identical protein binding; CC: basement membrane, extracellular matrix, extracellular region, extracellular space
Pathways:
UniProt: Q70UZ7
Entrez ID: 240675
|
Does Knockout of Nup85 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Nup85
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Nup85 (nucleoporin 85)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chemotaxis, cytokine-mediated signaling pathway, lamellipodium assembly, mRNA export from nucleus, mRNA transport, macrophage chemotaxis, nephron development, nucleocytoplasmic transport, positive regulation of DNA-templated transcription, protein import into nucleus, protein transport; MF: CCR2 chemokine receptor binding, structural constituent of nuclear pore; CC: actin cytoskeleton, chromosome, chromosome, centromeric region, ciliary basal body, cytoplasm, cytoskeleton, cytosol, kinetochore, membrane, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore outer ring, nucleoplasm, nucleus, plasma membrane, spindle
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, EML4 and NUDC in mitotic spindle formation, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q8R480
Entrez ID: 445007
|
Does Knockout of B4galt4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
B4galt4
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: B4galt4 (UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, glycosylation, keratan sulfate proteoglycan biosynthetic process, lactosylceramide biosynthetic process, lipid metabolic process, protein glycosylation; MF: N-acetyllactosamine synthase activity, UDP-galactosyltransferase activity, galactosyltransferase activity, glycosyltransferase activity, metal ion binding, transferase activity; CC: Golgi apparatus, Golgi membrane, extracellular region, membrane
Pathways: Asparagine N-linked glycosylation, Glycosaminoglycan biosynthesis - keratan sulfate - Mus musculus (mouse), Glycosaminoglycan metabolism, Glycosphingolipid biosynthesis - lacto and neolacto series - Mus musculus (mouse), Keratan sulfate biosynthesis, Keratan sulfate/keratin metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of proteins, N-Glycan antennae elongation, N-glycan antennae elongation in the medial/trans-Golgi, Post-translational protein modification, Transport to the Golgi and subsequent modification
UniProt: Q9JJ04
Entrez ID: 56375
|
Does Knockout of Ncdn in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Ncdn
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ncdn (neurochondrin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone resorption, neuron projection development, regulation of neuronal synaptic plasticity, regulation of postsynaptic neurotransmitter receptor internalization; CC: axon, cell projection, cytoplasm, cytosol, dendrite, endosome, endosome membrane, glutamatergic synapse, membrane, neuron projection, neuronal cell body, nucleus, perikaryon, postsynapse, synapse
Pathways:
UniProt: Q9Z0E0
Entrez ID: 26562
|
Does Knockout of Tmem232 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Tmem232
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tmem232 (transmembrane protein 232)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell projection organization, flagellated sperm motility, maintenance of protein complex location, spermatid cytoplasm removal during spermiation of flagellated sperm, spermatogenesis; MF: molecular_function, protein binding; CC: cellular_component, membrane, outer dense fiber
Pathways:
UniProt: Q5K6N0
Entrez ID: 381107
|
Does Knockout of Lrrc37a in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Lrrc37a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Lrrc37a (leucine rich repeat containing 37A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt:
Entrez ID: 237954
|
Does Knockout of Col4a3 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Col4a3
|
response to virus
|
Microglial Cell Line
|
Gene: Col4a3 (collagen, type IV, alpha 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell surface receptor signaling pathway, collagen-activated tyrosine kinase receptor signaling pathway, endothelial cell apoptotic process, glomerular basement membrane development, negative regulation of angiogenesis, negative regulation of vascular endothelial cell proliferation; MF: extracellular matrix structural constituent, extracellular matrix structural constituent conferring tensile strength, integrin binding; CC: basement membrane, collagen trimer, collagen type IV trimer, endoplasmic reticulum, extracellular matrix, extracellular region
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Assembly of collagen fibrils and other multimeric structures, Axon guidance, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen degradation, Collagen formation, Crosslinking of collagen fibrils, Degradation of the extracellular matrix, Developmental Biology, ECM-receptor interaction - Mus musculus (mouse), Extracellular matrix organization, Fibronectin matrix formation, Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Integrin cell surface interactions, Laminin interactions, NCAM signaling for neurite out-growth, NCAM1 interactions, Nervous system development, Non-integrin membrane-ECM interactions, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Small cell lung cancer - Mus musculus (mouse)
UniProt: Q9QZS0
Entrez ID: 12828
|
Does Knockout of Fabp9 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Fabp9
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Fabp9 (fatty acid binding protein 9, testis)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: lipid binding, long-chain fatty acid binding; CC: acrosomal vesicle, cytoplasm, cytosol, nucleus
Pathways: Metabolism, Metabolism of lipids, Triglyceride catabolism, Triglyceride metabolism
UniProt: O08716
Entrez ID: 21884
|
Does Knockout of Il16 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
Il16
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Il16 (interleukin 16)
Type: protein-coding
Summary: Enables cytokine activity. Involved in cytokine-mediated signaling pathway. Acts upstream of or within several processes, including induction of positive chemotaxis; positive regulation of chemokine production; and positive regulation of neutrophil activation. Located in collagen-containing extracellular matrix. Is expressed in several structures, including foregut; jaw; limb; respiratory system; and vibrissa. Human ortholog(s) of this gene implicated in asthma; colorectal adenocarcinoma; and prostate cancer. Orthologous to human IL16 (interleukin 16). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: chemotaxis, cytokine-mediated signaling pathway, immune system process, induction of positive chemotaxis, leukocyte chemotaxis, positive regulation of chemokine production, positive regulation of gene expression, positive regulation of inflammatory response, positive regulation of interleukin-1 alpha production, positive regulation of interleukin-12 production, positive regulation of interleukin-6 production, positive regulation of neutrophil activation, regulation of calcium ion transport; MF: CD4 receptor binding, cytokine activity, protein binding, signaling receptor binding; CC: Flemming body, cytoplasm, cytosol, extracellular matrix, extracellular region, extracellular space, focal adhesion, nuclear speck, nucleus, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Other interleukin signaling, Signaling by Interleukins
UniProt: O54824
Entrez ID: 16170
|
Does Knockout of Tfg in Cytotoxic T-lymphocyte (CD8+ T cells) causally result in cell proliferation?
| 1
| 2,411
|
Knockout
|
Tfg
|
cell proliferation
|
Cytotoxic T-lymphocyte (CD8+ T cells)
|
Gene: Tfg (Trk-fused gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPII vesicle coating, endoplasmic reticulum to Golgi vesicle-mediated transport; MF: identical protein binding; CC: cytosol, endoplasmic reticulum exit site
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Thyroid cancer - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q8C2C6, Q9Z1A1, B8JJG8, F6QJV5, B8JJG9, B8JJG7
Entrez ID: 21787
|
Does Knockout of Efna1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Efna1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Efna1 (ephrin A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, aortic valve morphogenesis, axon guidance, cell migration, central nervous system neuron differentiation, endocardial cushion to mesenchymal transition involved in heart valve formation, ephrin receptor signaling pathway, mitral valve morphogenesis, negative regulation of MAPK cascade, negative regulation of dendritic spine morphogenesis, negative regulation of epithelial to mesenchymal transition, negative regulation of macromolecule metabolic process, negative regulation of proteolysis involved in protein catabolic process, negative regulation of thymocyte apoptotic process, negative regulation of transcription by RNA polymerase II, notochord formation, positive regulation of MAPK cascade, positive regulation of amyloid precursor protein catabolic process, positive regulation of amyloid-beta formation, positive regulation of intracellular signal transduction, protein stabilization, regulation of angiogenesis, regulation of axonogenesis, regulation of biological quality, regulation of blood vessel endothelial cell migration, regulation of cell adhesion mediated by integrin, regulation of peptidyl-tyrosine phosphorylation, substrate adhesion-dependent cell spreading; MF: ephrin receptor binding, protein binding; CC: extracellular region, membrane, plasma membrane, side of membrane
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Developmental Biology, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHA-mediated growth cone collapse, MAPK signaling pathway - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Nervous system development, PI3K-Akt signaling pathway - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse)
UniProt: P52793
Entrez ID: 13636
|
Does Knockout of Tmc1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Tmc1
|
phagocytosis
|
macrophage
|
Gene: Tmc1 (transmembrane channel-like gene family 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: auditory receptor cell development, calcium ion transmembrane transport, detection of mechanical stimulus involved in sensory perception of sound, monoatomic ion transmembrane transport, monoatomic ion transport, regulation of calcium ion transmembrane transport, sensory perception of sound, vestibular reflex; MF: calcium channel activity, mechanosensitive monoatomic ion channel activity, protein binding, voltage-gated calcium channel activity; CC: external side of plasma membrane, membrane, plasma membrane, stereocilium, stereocilium tip
Pathways:
UniProt: Q8R4P5
Entrez ID: 13409
|
Does Knockout of Ralb in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Ralb
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ralb (v-ral simian leukemia viral oncogene B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, apoptotic process, cell division, positive regulation of autophagosome assembly, positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of innate immune response, receptor internalization, regulation of exocyst assembly, regulation of exocyst localization, signal transduction; MF: ATPase binding, G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, nucleotide binding, ubiquitin protein ligase binding; CC: membrane, midbody, plasma membrane
Pathways: Colorectal cancer - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse)
UniProt: Q9JIW9
Entrez ID: 64143
|
Does Knockout of Ttll5 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 163
|
Knockout
|
Ttll5
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ttll5 (tubulin tyrosine ligase-like family, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fertilization, flagellated sperm motility, retina development in camera-type eye, sperm axoneme assembly, spermatogenesis; MF: ATP binding, ligase activity, metal ion binding, nucleotide binding, protein-glutamic acid ligase activity, elongating, protein-glutamic acid ligase activity, initiating, tubulin binding, tubulin-glutamic acid ligase activity; CC: 9+0 non-motile cilium, cell projection, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, microtubule, nucleus, plasma membrane
Pathways: Carboxyterminal post-translational modifications of tubulin, Metabolism of proteins, Post-translational protein modification
UniProt: Q8CHB8
Entrez ID: 320244
|
Does Knockout of Pbrm1 in Pancreatic Cell Line causally result in cell proliferation?
| 1
| 2,191
|
Knockout
|
Pbrm1
|
cell proliferation
|
Pancreatic Cell Line
|
Gene: Pbrm1 (polybromo 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst formation, blood vessel remodeling, cardiac vascular smooth muscle cell development, chromatin organization, chromatin remodeling, epicardium-derived cardiac endothelial cell differentiation, heart development, heart morphogenesis, negative regulation of cell population proliferation, placenta development, positive regulation of DNA-templated transcription, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of dendritic spine development, positive regulation of double-strand break repair, positive regulation of myoblast differentiation, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II, transcription elongation by RNA polymerase II, vasculogenesis involved in coronary vascular morphogenesis; MF: DNA binding, chromatin binding, protein binding; CC: RSC-type complex, SWI/SNF complex, chromatin, chromosome, kinetochore, nuclear matrix, nucleoplasm, nucleus
Pathways: Hepatocellular carcinoma - Mus musculus (mouse)
UniProt: Q8BSQ9
Entrez ID: 66923
|
Does Knockout of Scn3a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Scn3a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Scn3a (sodium channel, voltage-gated, type III, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: behavioral response to pain, cellular response to antibiotic, membrane depolarization during action potential, monoatomic ion transmembrane transport, monoatomic ion transport, neuronal action potential, response to pyrethroid, sensory perception of pain, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: calmodulin binding, monoatomic cation channel activity, monoatomic ion channel activity, sodium channel activity, voltage-gated sodium channel activity; CC: axon, basal plasma membrane, membrane, monoatomic ion channel complex, neuronal cell body, plasma membrane, sarcoplasm, voltage-gated sodium channel complex
Pathways: Taste transduction - Mus musculus (mouse)
UniProt: A2ASI5
Entrez ID: 20269
|
Does Knockout of Gab1 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Gab1
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Gab1 (growth factor receptor bound protein 2-associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cellular response to vascular endothelial growth factor stimulus, endothelial cell chemotaxis, epidermal growth factor receptor signaling pathway, epidermis development, heart development, interleukin-6-mediated signaling pathway, intracellular signal transduction, labyrinthine layer development, myoblast migration, platelet-derived growth factor receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of angiogenesis, positive regulation of blood vessel endothelial cell migration, regulation of cell migration, response to hepatocyte growth factor, response to oxidative stress, signal transduction, vascular endothelial growth factor signaling pathway; MF: protein binding, signaling adaptor activity; CC: cell cortex, cell-cell junction, cytoplasm, cytosol
Pathways: Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Developmental Biology, Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, ErbB signaling pathway - Mus musculus (mouse), Erythropoietin activates Phosphoinositide-3-kinase (PI3K), GAB1 signalosome, Gastric cancer - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, MET activates PI3K/AKT signaling, MET activates PTPN11, MET activates RAP1 and RAC1, MET promotes cell motility, MET receptor recycling, Negative regulation of the PI3K/AKT network, Nervous system development, Neurotrophin signaling pathway - Mus musculus (mouse), PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI3K events in ERBB2 signaling, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Phospholipase D signaling pathway - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RET signaling, Ras signaling pathway - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), Signal Transduction, Signaling by EGFR, Signaling by ERBB2, Signaling by Erythropoietin, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Insulin receptor, Signaling by MET, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
UniProt: Q9QYY0
Entrez ID: 14388
|
Does Knockout of Prn in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Prn
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Prn (prion protein readthrough transcript)
Type: protein-coding
Summary: This locus represents naturally occurring readthrough transcription between the neighboring Prnp (major prion protein) and Prnd (prion-like protein doppel) genes on chromosome 2. The readthrough transcript encodes a protein that shares sequence identity with the downstream gene product but its N-terminal region is distinct due to the presence of an in-frame, upstream AUG compared to the downstream gene. [provided by RefSeq, May 2013].
Gene Ontology:
Pathways:
UniProt: A0A075B668
Entrez ID: 111368
|
Does Knockout of Sox11 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Sox11
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Sox11 (SRY (sex determining region Y)-box 11)
Type: protein-coding
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including camera-type eye development; nervous system development; and regulation of gene expression. Acts upstream of or within skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 9. Orthologous to human SOX11 (SRY-box transcription factor 11). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: brain development, camera-type eye morphogenesis, cell differentiation, central nervous system development, closure of optic fissure, cornea development in camera-type eye, embryonic digestive tract morphogenesis, embryonic skeletal system morphogenesis, eyelid development in camera-type eye, glial cell development, glial cell proliferation, hard palate development, kidney development, lens morphogenesis in camera-type eye, lung morphogenesis, negative regulation of gene expression, negative regulation of glial cell proliferation, negative regulation of lymphocyte proliferation, negative regulation of transcription by RNA polymerase II, negative regulation of transcription regulatory region DNA binding, nervous system development, neuroepithelial cell differentiation, neuron differentiation, noradrenergic neuron differentiation, oligodendrocyte development, outflow tract morphogenesis, positive regulation of BMP signaling pathway, positive regulation of DNA-templated transcription, positive regulation of cell development, positive regulation of gene expression, positive regulation of hippo signaling, positive regulation of hormone secretion, positive regulation of lens epithelial cell proliferation, positive regulation of neurogenesis, positive regulation of neuron differentiation, positive regulation of ossification, positive regulation of osteoblast differentiation, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of transforming growth factor beta receptor signaling pathway, skeletal muscle cell differentiation, soft palate development, spinal cord development, sympathetic nervous system development, ventricular septum morphogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, transcription cis-regulatory region binding; CC: nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: Q7M6Y2
Entrez ID: 20666
|
Does Knockout of Mettl18 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Mettl18
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Mettl18 (methyltransferase like 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, peptidyl-lysine monomethylation, regulation of rRNA processing, regulation of ribosome biogenesis, regulation of translation, regulation of translational elongation; MF: heat shock protein binding, methyltransferase activity, protein methyltransferase activity, protein-L-histidine N-tele-methyltransferase activity, transferase activity; CC: cytoplasm, cytosol, nucleolus, nucleus, protein-containing complex
Pathways:
UniProt: Q9CZ09
Entrez ID: 69962
|
Does Knockout of Prag1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Prag1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Prag1 (PEAK1 related kinase activating pseudokinase 1)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity and protein kinase activity. Involved in regulation of Notch signaling pathway. Located in nucleus. Is expressed in forebrain; spinal cord; telencephalon; and vibrissa. Orthologous to human PRAG1 (PEAK1 related, kinase-activating pseudokinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell migration, negative regulation of neuron projection development, positive regulation of Rho protein signal transduction, regulation of Notch signaling pathway, regulation of cell motility, regulation of cell shape; MF: ATP binding, identical protein binding, protein binding, protein kinase activity; CC: anchoring junction, cytoplasm, focal adhesion, nucleus
Pathways: RHO GTPase cycle, RND2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q571I4
Entrez ID: 244418
|
Does Knockout of Cd80 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 2,176
|
Knockout
|
Cd80
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cd80 (CD80 antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation, T cell costimulation, cell surface receptor signaling pathway, cellular response to lipopolysaccharide, immune response, immune system process, negative regulation of T cell mediated immunity, negative regulation of T cell proliferation, positive regulation of T cell proliferation, positive regulation of alpha-beta T cell proliferation, regulation of immune system process; MF: coreceptor activity, protein binding, receptor ligand activity; CC: cell surface, external side of plasma membrane, membrane, plasma membrane, protein complex involved in cell adhesion
Pathways: Adaptive Immune System, Allograft rejection - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), CD28 dependent PI3K/Akt signaling, CD28 dependent Vav1 pathway, Cell adhesion molecules - Mus musculus (mouse), Co-inhibition by CTLA4, Co-stimulation by CD28, Graft-versus-host disease - Mus musculus (mouse), Immune System, Intestinal immune network for IgA production - Mus musculus (mouse), Intracellular signaling by second messengers, Negative regulation of the PI3K/AKT network, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Regulation of T cell activation by CD28 family, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Systemic lupus erythematosus - Mus musculus (mouse), Toll-like receptor signaling pathway - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse)
UniProt: Q00609
Entrez ID: 12519
|
Does Knockout of Sat1 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Sat1
|
response to virus
|
Microglial Cell Line
|
Gene: Sat1 (spermidine/spermine N1-acetyl transferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, polyamine biosynthetic process, polyamine catabolic process, polyamine metabolic process, putrescine catabolic process, regulation of cell population proliferation, spermidine acetylation, spermine catabolic process; MF: N-acetyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, diamine N-acetyltransferase activity, identical protein binding, spermidine binding, transferase activity; CC: cytoplasm, cytosol
Pathways: Arginine and proline metabolism - Mus musculus (mouse), Ferroptosis - Mus musculus (mouse), Interconversion of polyamines, Metabolism, Metabolism of amino acids and derivatives, Metabolism of polyamines
UniProt: P48026
Entrez ID: 20229
|
Does Knockout of Clic4 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Clic4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Clic4 (chloride intracellular channel 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, branching morphogenesis of an epithelial tube, cellular response to calcium ion, chloride transmembrane transport, chloride transport, endothelial cell morphogenesis, epidermal cell differentiation, fertilization, keratinocyte differentiation, monoatomic ion transmembrane transport, monoatomic ion transport, multicellular organism growth, negative regulation of cell migration, retina vasculature morphogenesis in camera-type eye, vacuolar acidification; MF: chloride channel activity, oxidoreductase activity, protein binding, protein-containing complex binding; CC: anchoring junction, apical part of cell, cell surface, cell-cell junction, centrosome, chloride channel complex, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytoskeleton, cytosol, membrane, microtubule cytoskeleton, microvillus, midbody, mitochondrial outer membrane, mitochondrion, monoatomic ion channel complex, nuclear matrix, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q9QYB1
Entrez ID: 29876
|
Does Knockout of S100a2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
S100a2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: S100a2 (S100 calcium binding protein A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endothelial cell migration; MF: calcium ion binding, calcium-dependent protein binding, identical protein binding
Pathways:
UniProt: J3QMC7
Entrez ID: 628324
|
Does Knockout of Pcdhga7 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Pcdhga7
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Pcdhga7 (protocadherin gamma subfamily A, 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, molecular_function; CC: membrane, plasma membrane
Pathways:
UniProt: A0A0A6YXT1, Q6DD96
Entrez ID: 93715
|
Does Knockout of Styxl1 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Styxl1
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Styxl1 (serine/threonine/tyrosine interacting-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of stress granule assembly, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of neuron projection development, regulation of intrinsic apoptotic signaling pathway; MF: phosphatase inhibitor activity, protein phosphatase binding, protein serine/threonine phosphatase activity, pseudophosphatase activity; CC: mitochondrion
Pathways:
UniProt: Q9DAG7, Q9DAR2, D3YZ02, J3QNW1, J3QK74
Entrez ID: 76571
|
Does Knockout of Cables2 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Cables2
|
phagocytosis
|
macrophage
|
Gene: Cables2 (CDK5 and Abl enzyme substrate 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell division, regulation of cell cycle; CC: cellular_component, cytosol
Pathways:
UniProt: Q8K3M5
Entrez ID: 252966
|
Does Knockout of Serpina9 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Serpina9
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Serpina9 (serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q9D7D2
Entrez ID: 71907
|
Does Knockout of Dlst in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Dlst
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dlst (dihydrolipoamide S-succinyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 2-oxoglutarate decarboxylation to succinyl-CoA, 2-oxoglutarate metabolic process, L-lysine catabolic process to acetyl-CoA via saccharopine, succinyl-CoA metabolic process, tricarboxylic acid cycle; MF: acyltransferase activity, dihydrolipoyllysine-residue succinyltransferase activity, heat shock protein binding, protein binding, protein-folding chaperone binding, transferase activity; CC: cytosol, mitochondrial matrix, mitochondrion, myelin sheath, nucleoplasm, nucleus, oxoadipate dehydrogenase complex, oxoglutarate dehydrogenase complex, sarcolemma
Pathways: 2-ketoglutarate dehydrogenase complex, Aerobic respiration and respiratory electron transport, Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Glycine degradation, Glyoxylate metabolism and glycine degradation, Lysine catabolism, Lysine degradation - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Metabolism of proteins, OADH complex synthesizes glutaryl-CoA from 2-OA, OGDH complex synthesizes succinyl-CoA from 2-OG, Post-translational protein modification, Protein lipoylation, Tryptophan metabolism - Mus musculus (mouse)
UniProt: Q9D2G2
Entrez ID: 78920
|
Does Knockout of Gbp7 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Gbp7
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gbp7 (guanylate binding protein 7)
Type: protein-coding
Summary: Enables GTP binding activity and GTPase activity. Involved in several processes, including cellular response to interferon-beta; cytolysis in another organism; and defense response to other organism. Acts upstream of or within adhesion of symbiont to host and defense response to other organism. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Is expressed in thymus primordium. Orthologous to human GBP4 (guanylate binding protein 4) and GBP7 (guanylate binding protein 7). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: activation of innate immune response, adhesion of symbiont to host, cellular response to interferon-beta, cellular response to type II interferon, cytolysis in another organism, defense response to Gram-positive bacterium, defense response to bacterium, defense response to protozoan, defense response to virus, immune system process, innate immune response, negative regulation of cytokine production, negative regulation of receptor signaling pathway via JAK-STAT, negative regulation of type I interferon production, negative regulation of type III interferon production, positive regulation of viral genome replication, regulation of canonical NF-kappaB signal transduction, regulation of defense response; MF: GTP binding, GTPase activity, hydrolase activity, identical protein binding, nucleotide binding, protein binding, protein homodimerization activity; CC: Golgi apparatus, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, membrane, nucleus, perinuclear region of cytoplasm, plasma membrane, symbiont-containing vacuole membrane
Pathways: NOD-like receptor signaling pathway - Mus musculus (mouse)
UniProt: Q91Z40
Entrez ID: 229900
|
Does Knockout of Klhl15 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Klhl15
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Klhl15 (kelch-like 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of double-strand break repair via homologous recombination, nuclear protein quality control by the ubiquitin-proteasome system, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: ubiquitin-like ligase-substrate adaptor activity; CC: Cul3-RING ubiquitin ligase complex, nucleus
Pathways:
UniProt: A2AAX3
Entrez ID: 236904
|
Does Knockout of Sfxn2 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Sfxn2
|
response to virus
|
Microglial Cell Line
|
Gene: Sfxn2 (sideroflexin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid transport, mitochondrial transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, serine import into mitochondrion, transmembrane transport; MF: monoatomic ion transmembrane transporter activity, transmembrane transporter activity; CC: membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrion
Pathways:
UniProt: Q925N2
Entrez ID: 94279
|
Does Knockout of Nop53 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Nop53
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Nop53 (NOP53 ribosome biogenesis factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, cellular response to hypoxia, mitotic G2 DNA damage checkpoint signaling, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of protein-containing complex assembly, negative regulation of signal transduction by p53 class mediator, negative regulation of transcription by RNA polymerase II, negative regulation of transcription of nucleolar large rRNA by RNA polymerase I, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein K63-linked deubiquitination, protein localization to nucleolus, protein localization to nucleoplasm, protein stabilization, rRNA processing, regulation of RIG-I signaling pathway, regulation of aerobic respiration, regulation of apoptotic process, regulation of cell cycle, regulation of protein phosphorylation, regulation of signal transduction by p53 class mediator, ribosomal large subunit assembly, ribosome biogenesis; MF: 5S rRNA binding, identical protein binding, p53 binding, protein binding; CC: cytosol, fibrillar center, nucleolus, nucleoplasm, nucleus, rDNA heterochromatin
Pathways:
UniProt: Q8BK35
Entrez ID: 68077
|
Does Knockout of Stab1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Stab1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Stab1 (stabilin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-cell signaling, defense response to bacterium, endocytosis, inflammatory response, negative regulation of angiogenesis; MF: calcium ion binding, hyaluronic acid binding, low-density lipoprotein particle binding, low-density lipoprotein particle receptor activity, scavenger receptor activity; CC: cytoplasm, membrane, plasma membrane
Pathways:
UniProt: F7CT68, G3X973, F7BK35
Entrez ID: 192187
|
Does Knockout of Sorbs3 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Sorbs3
|
cell cycle progression
|
breast epithelium
|
Gene: Sorbs3 (sorbin and SH3 domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-substrate adhesion, negative regulation of transcription by RNA polymerase II, positive regulation of MAPK cascade, positive regulation of stress fiber assembly; MF: vinculin binding; CC: anchoring junction, cell-substrate junction, cytoplasm, cytoskeleton, focal adhesion, nucleus
Pathways: Muscle contraction, Smooth Muscle Contraction
UniProt: Q9R1Z8
Entrez ID: 20410
|
Does Knockout of Pign in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Pign
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pign (phosphatidylinositol glycan anchor biosynthesis, class N)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GPI anchor biosynthetic process; MF: mannose-ethanolamine phosphotransferase activity, transferase activity; CC: cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Mus musculus (mouse)
UniProt: A0A087WQ32, G3X9F1, A0A087WS03, A0A087WNT9
Entrez ID: 27392
|
Does Knockout of Timd4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Timd4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Timd4 (T cell immunoglobulin and mucin domain containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic cell clearance, cytoskeletal rearrangement involved in phagocytosis, engulfment; MF: phosphatidylserine binding, protein binding
Pathways:
UniProt: Q6U7R4
Entrez ID: 276891
|
Does Knockout of Src in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Src
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Src (Rous sarcoma oncogene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, TORC1 signaling, angiotensin-activated signaling pathway, bone resorption, branching involved in mammary gland duct morphogenesis, canonical glycolysis, cell adhesion, cell differentiation, cell migration, cellular response to angiotensin, cellular response to fluid shear stress, cellular response to hydrogen peroxide, cellular response to nutrient levels, cellular response to peptide hormone stimulus, cellular response to platelet-derived growth factor stimulus, cellular response to progesterone stimulus, cellular response to reactive oxygen species, cellular response to transforming growth factor beta stimulus, epidermal growth factor receptor signaling pathway, focal adhesion assembly, forebrain development, gamete generation, immune system process, integrin-mediated signaling pathway, interleukin-6-mediated signaling pathway, intestinal epithelial cell development, intracellular signal transduction, lactation, negative regulation of TORC1 signaling, negative regulation of anoikis, negative regulation of apoptotic process, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of focal adhesion assembly, negative regulation of gene expression, negative regulation of hippo signaling, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of mitochondrial depolarization, negative regulation of neutrophil activation, negative regulation of protein-containing complex assembly, negative regulation of telomere maintenance, negative regulation of transcription by RNA polymerase II, neurotrophin TRK receptor signaling pathway, odontogenesis, oogenesis, osteoclast development, positive regulation of ERK1 and ERK2 cascade, positive regulation of Notch signaling pathway, positive regulation of Ras protein signal transduction, positive regulation of TORC1 signaling, positive regulation of apoptotic process, positive regulation of bone resorption, positive regulation of canonical Wnt signaling pathway, positive regulation of carbohydrate metabolic process, positive regulation of cell adhesion, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cell size, positive regulation of cytokine production, positive regulation of dephosphorylation, positive regulation of epithelial cell migration, positive regulation of gene expression, positive regulation of glucose metabolic process, positive regulation of glycolytic process, positive regulation of insulin receptor signaling pathway, positive regulation of intracellular signal transduction, positive regulation of lamellipodium morphogenesis, positive regulation of male germ cell proliferation, positive regulation of neural precursor cell proliferation, positive regulation of ovarian follicle development, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of platelet-derived growth factor receptor-beta signaling pathway, positive regulation of podosome assembly, positive regulation of protein localization, positive regulation of protein localization to nucleus, positive regulation of protein processing, positive regulation of protein transport, positive regulation of small GTPase mediated signal transduction, positive regulation of small molecule metabolic process, positive regulation of smooth muscle cell migration, positive regulation of vascular associated smooth muscle cell proliferation, positive regulation of wound healing, primary ovarian follicle growth, progesterone receptor signaling pathway, proteasome-mediated ubiquitin-dependent protein catabolic process, protein destabilization, protein deubiquitination, regulation of caveolin-mediated endocytosis, regulation of cell projection assembly, regulation of cell-cell adhesion, regulation of early endosome to late endosome transport, regulation of epithelial cell migration, regulation of heart rate by cardiac conduction, regulation of intracellular estrogen receptor signaling pathway, regulation of toll-like receptor 3 signaling pathway, response to interleukin-1, stress fiber assembly, substrate adhesion-dependent cell spreading, toll-like receptor 3 signaling pathway, transcytosis, transforming growth factor beta receptor signaling pathway, uterus development, vasodilation; MF: ATP binding, BMP receptor binding, SH2 domain binding, cell adhesion molecule binding, connexin binding, enzyme binding, ephrin receptor binding, heme binding, insulin receptor binding, integrin binding, ionotropic glutamate receptor binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, nuclear estrogen receptor binding, nucleotide binding, phospholipase activator activity, phospholipase binding, phosphoprotein binding, protein binding, protein domain specific binding, protein kinase C binding, protein kinase activity, protein kinase binding, protein tyrosine kinase activity, protein-containing complex binding, scaffold protein binding, signaling receptor activator activity, signaling receptor binding, transferase activity, transmembrane transporter binding; CC: actin filament, anchoring junction, axon, caveola, cell junction, cell-cell junction, cytoplasm, cytoskeleton, cytosol, dendritic filopodium, dendritic growth cone, focal adhesion, glutamatergic synapse, late endosome, lysosome, membrane, mitochondrial inner membrane, mitochondrion, mitochondrion-derived vesicle, neuron to neuron synapse, neuronal cell body, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, podosome, postsynaptic specialization, intracellular component, ruffle membrane, synaptic membrane
Pathways: ADP signalling through P2Y purinoceptor 1, Activated NTRK3 signals through PI3K, Adaptive Immune System, Adherens junction - Mus musculus (mouse), Adherens junctions interactions, Autophagy, Axon guidance, Axon guidance - Mus musculus (mouse), Bacterial invasion of epithelial cells - Mus musculus (mouse), Bladder cancer - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Cell Cycle, Cell Cycle, Mitotic, Cell junction organization, Cell surface interactions at the vascular wall, Cell-Cell communication, Cell-cell junction organization, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Co-inhibition by CTLA4, Co-stimulation by CD28, Cyclin D associated events in G1, DCC mediated attractive signaling, Degradation of CDH1, Developmental Biology, Downregulation of ERBB4 signaling, Downstream signal transduction, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHA-mediated growth cone collapse, EPHB-mediated forward signaling, ESR-mediated signaling, Endocytosis - Mus musculus (mouse), Ephrin signaling, ErbB signaling pathway - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), Extra-nuclear estrogen signaling, FCGR activation, Fcgamma receptor (FCGR) dependent phagocytosis, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), G alpha (i) signalling events, G1 Phase, GAB1 signalosome, GABAergic synapse - Mus musculus (mouse), GP1b-IX-V activation signalling, GPCR downstream signalling, GRB2:SOS provides linkage to MAPK signaling for Integrins , Gap junction - Mus musculus (mouse), Gap junction trafficking and regulation, Gene expression (Transcription), Generic Transcription Pathway, GnRH signaling pathway - Mus musculus (mouse), Hemostasis, Hepatitis B - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Immune System, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Innate Immune System, Integrin signaling, Intracellular signaling by second messengers, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), L1CAM interactions, Lipid and atherosclerosis - Mus musculus (mouse), MAP2K and MAPK activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MET activates PTK2 signaling, MET promotes cell motility, Macroautophagy, Membrane Trafficking, Mitophagy, Mitophagy - animal - Mus musculus (mouse), Mitotic G1 phase and G1/S transition, Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of the PI3K/AKT network, Nervous system development, Netrin-1 signaling, Neutrophil extracellular trap formation - Mus musculus (mouse), Nuclear signaling by ERBB4, Oxytocin signaling pathway - Mus musculus (mouse), PECAM1 interactions, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Platelet Aggregation (Plug Formation), Platelet activation - Mus musculus (mouse), Platelet activation, signaling and aggregation, Prolactin signaling pathway - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RAF activation, RAF/MAP kinase cascade, RET signaling, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA Polymerase II Transcription, Rap1 signaling pathway - Mus musculus (mouse), Receptor Mediated Mitophagy, Recycling pathway of L1, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of KIT signaling, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of gap junction activity, Relaxin signaling pathway - Mus musculus (mouse), Selective autophagy, Signal Transduction, Signal amplification, Signaling by EGFR, Signaling by ERBB2, Signaling by ERBB4, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by GPCR, Signaling by MET, Signaling by NTRK3 (TRKC), Signaling by NTRKs, Signaling by Nuclear Receptors, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by SCF-KIT, Signaling by VEGF, Spry regulation of FGF signaling, Thrombin signalling through proteinase activated receptors (PARs), Thyroid hormone signaling pathway - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Transcriptional regulation by RUNX3, Tuberculosis - Mus musculus (mouse), VEGF signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, VEGFR2 mediated cell proliferation, Vesicle-mediated transport, Viral carcinogenesis - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), p130Cas linkage to MAPK signaling for integrins
UniProt: P05480
Entrez ID: 20779
|
Does Knockout of Pmp22 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Pmp22
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pmp22 (peripheral myelin protein 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Schwann cell development, Schwann cell differentiation, Schwann cell migration, actin cytoskeleton organization, adult locomotory behavior, adult walking behavior, aggresome assembly, apoptotic process, autophagy, axon development, basement membrane organization, bleb assembly, cell adhesion, cell differentiation, cellular response to heat, cellular response to unfolded protein, cholesterol metabolic process, fibroblast migration, gliogenesis, immune response, lamellipodium assembly, lipid metabolic process, mating, membrane raft organization, motor behavior, multicellular organism growth, muscle cell development, myelin assembly, myelination, myelination in peripheral nervous system, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of neuron projection development, nervous system development, neuromuscular junction development, skeletal muscle fiber, neuromuscular process, neuronal action potential, neuronal action potential propagation, neuronal ion channel clustering, paranodal junction assembly, peripheral nervous system development, peripheral nervous system neuron axonogenesis, positive regulation of gene expression, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of Schwann cell proliferation, regulation of apoptotic signaling pathway, regulation of cell cycle, regulation of gene expression, regulation of glial cell apoptotic process, regulation of inflammatory response, response to bacterium, response to endoplasmic reticulum stress, striated muscle cell differentiation, transmission of nerve impulse, vestibular reflex; MF: cytoskeletal motor activity, protein binding, protein serine/threonine kinase inhibitor activity; CC: bicellular tight junction, cell surface, compact myelin, integrin complex, laminin complex, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: P16646
Entrez ID: 18858
|
Does Knockout of Syt2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Syt2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Syt2 (synaptotagmin II)
Type: protein-coding
Summary: This gene encodes a member of the synaptotagmin protein family. Synaptotagmin proteins are involved in membrane trafficking and are characterized by an N-terminal transmembrane region as well as tandem calcium binding domains. The encoded protein is able to bind inositol polyphosphate and is thought to be involved in synaptic function and neurotransmitter release. [provided by RefSeq, Sep 2017].
Gene Ontology: BP: calcium-dependent activation of synaptic vesicle fusion, cell differentiation, positive regulation of dendrite extension, regulation of calcium ion-dependent exocytosis, regulation of synaptic vesicle exocytosis, vesicle-mediated transport; MF: SNARE binding, calcium ion binding, calcium ion sensor activity, calcium-dependent phospholipid binding, inositol 1,3,4,5 tetrakisphosphate binding, metal ion binding, phosphatidylserine binding, protein binding, syntaxin binding; CC: axon, chromaffin granule membrane, cytoplasm, cytoplasmic vesicle, dense core granule, exocytic vesicle, membrane, neuromuscular junction, plasma membrane, synapse, synaptic vesicle membrane
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Membrane Trafficking, Vesicle-mediated transport
UniProt: P46097
Entrez ID: 20980
|
Does Knockout of Abhd14a in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Abhd14a
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Abhd14a (abhydrolase domain containing 14A)
Type: protein-coding
Summary: Predicted to enable hydrolase activity. Located in cytoplasm. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and retina nuclear layer. Orthologous to human ABHD14A (abhydrolase domain containing 14A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cytoplasm, membrane
Pathways:
UniProt: E9PW22, E9Q136, A0A087WSL4, A0A087WS50, A0A087WQ50
Entrez ID: 68644
|
Does Knockout of Dync1li1 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Dync1li1
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Dync1li1 (dynein cytoplasmic 1 light intermediate chain 1)
Type: protein-coding
Summary: Predicted to enable several functions, including GDP binding activity; dynein heavy chain binding activity; and identical protein binding activity. Predicted to be involved in several processes, including cellular response to nerve growth factor stimulus; early endosome to recycling endosome transport; and regulation of cell cycle process. Predicted to be located in cytoplasmic vesicle; kinetochore; and spindle pole. Predicted to be part of cytoplasmic dynein complex. Predicted to colocalize with centrosome. Orthologous to human DYNC1LI1 (dynein cytoplasmic 1 light intermediate chain 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell division, cellular response to nerve growth factor stimulus, early endosome to recycling endosome transport, microtubule cytoskeleton organization, microtubule-based movement, positive regulation of mitotic cell cycle spindle assembly checkpoint, regulation of centrosome cycle, regulation of vesicle-mediated transport; MF: ATP binding, GDP binding, dynein heavy chain binding, identical protein binding, microtubule motor activity, molecular adaptor activity, nucleotide binding, protein-macromolecule adaptor activity; CC: centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoplasmic dynein complex, cytoskeleton, dynein complex, endocytic vesicle membrane, endosome, kinetochore, late endosome, membrane, microtubule, recycling endosome membrane, spindle pole
Pathways: Adaptive Immune System, Aggrephagy, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Asparagine N-linked glycosylation, Autophagy, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, EML4 and NUDC in mitotic spindle formation, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Immune System, Innate Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, M Phase, MHC class II antigen presentation, Macroautophagy, Membrane Trafficking, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Neutrophil degranulation, Phagosome - Mus musculus (mouse), Post-translational protein modification, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Salmonella infection - Mus musculus (mouse), Selective autophagy, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transport to the Golgi and subsequent modification, Vasopressin-regulated water reabsorption - Mus musculus (mouse), Vesicle-mediated transport
UniProt: Q8R1Q8
Entrez ID: 235661
|
Does Knockout of Mipol1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Mipol1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mipol1 (mirror-image polydactyly 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, molecular_function
Pathways:
UniProt: E9PZ24, G3UVV8
Entrez ID: 73490
|
Does Knockout of Herc1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Herc1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Herc1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone mineralization, bone remodeling, brain development, cerebellar Purkinje cell differentiation, corpus callosum development, gene expression, negative regulation of autophagy, neuromuscular process controlling balance, neuron projection development; MF: molecular_function, transferase activity, ubiquitin-protein transferase activity; CC: cellular_component, cytoplasm
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: F6RXM1, E9PZP8
Entrez ID: 235439
|
Does Knockout of Acot6 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Acot6
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Acot6 (acyl-CoA thioesterase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acyl-CoA metabolic process, fatty acid metabolic process, lipid metabolic process; MF: carboxylic ester hydrolase activity, fatty acyl-CoA hydrolase activity, hydrolase activity, thiolester hydrolase activity; CC: cytosol, peroxisome
Pathways: acyl-CoA hydrolysis
UniProt: Q32Q92
Entrez ID: 217700
|
Does Knockout of Acbd7 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Acbd7
|
phagocytosis
|
macrophage
|
Gene: Acbd7 (acyl-Coenzyme A binding domain containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, energy homeostasis, fatty acid metabolic process, gene expression, leptin-mediated signaling pathway, response to food; MF: fatty-acyl-CoA binding, lipid binding
Pathways: Fatty acid metabolism, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation
UniProt: Q9D258
Entrez ID: 78245
|
Does Knockout of Gzmk in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Gzmk
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gzmk (granzyme K)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of membrane attack complex, complement activation, complement activation, GZMK pathway, granzyme-mediated programmed cell death signaling pathway, killing of cells of another organism, leukocyte chemotaxis involved in immune response, opsonization, positive regulation of inflammatory response, positive regulation of release of cytochrome c from mitochondria, protein maturation, proteolysis, zymogen activation; MF: glycosaminoglycan binding, hydrolase activity, pattern recognition receptor activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular space, symbiont cell surface
Pathways:
UniProt: O35205
Entrez ID: 14945
|
Does Knockout of Tmem126b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Tmem126b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tmem126b (transmembrane protein 126B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial respiratory chain complex I assembly, mitochondrion organization, response to food; CC: membrane, mitochondrial membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, Respiratory electron transport
UniProt: Q9D1R1
Entrez ID: 68472
|
Does Knockout of Cldnd2 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Cldnd2
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Cldnd2 (claudin domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q9D9H2
Entrez ID: 74276
|
Does Knockout of Haus7 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,308
|
Knockout
|
Haus7
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Haus7 (HAUS augmin-like complex, subunit 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, centrosome cycle, microtubule organizing center organization, spindle assembly; MF: microtubule minus-end binding, thioesterase binding; CC: HAUS complex, centrosome, ciliary basal body, cytoplasm, cytoskeleton, microtubule, mitotic spindle microtubule, nucleolus, plasma membrane, spindle
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q8BKT8
Entrez ID: 73738
|
Does Knockout of Pld5 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Pld5
|
phagocytosis
|
macrophage
|
Gene: Pld5 (phospholipase D family member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: catalytic activity, hydrolase activity, acting on ester bonds, molecular_function; CC: cellular_component, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q3UNN8
Entrez ID: 319455
|
Does Knockout of Atp7b in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Atp7b
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Atp7b (ATPase, copper transporting, beta polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to copper ion, copper ion export, copper ion import, copper ion transport, establishment of localization in cell, intracellular copper ion homeostasis, intracellular zinc ion homeostasis, lactation, monoatomic cation transport, monoatomic ion transport, protein maturation, response to copper ion, sequestering of calcium ion; MF: ATP binding, ATP hydrolysis activity, ATPase-coupled monoatomic cation transmembrane transporter activity, P-type divalent copper transporter activity, P-type monovalent copper transporter activity, copper ion binding, copper ion transmembrane transporter activity, metal ion binding, nucleotide binding, zinc ion binding; CC: Golgi apparatus, apical part of cell, basolateral plasma membrane, bicellular tight junction, cytoplasmic vesicle, endosome, late endosome, membrane, perinuclear region of cytoplasm, plasma membrane, tight junction, trans-Golgi network, trans-Golgi network membrane
Pathways: Ion channel transport, Ion transport by P-type ATPases, Mineral absorption - Mus musculus (mouse), Transport of small molecules, copper transport II
UniProt: Q64446
Entrez ID: 11979
|
Does Knockout of Dnajb12 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Dnajb12
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Dnajb12 (DnaJ heat shock protein family (Hsp40) member B12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, cellular response to misfolded protein, protein folding, protein-containing complex assembly; MF: Hsp70 protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear membrane, nucleus
Pathways: Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: Q9QYI4
Entrez ID: 56709
|
Does Knockout of Pi15 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Pi15
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pi15 (peptidase inhibitor 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: extracellular region, extracellular space
Pathways:
UniProt: Q8BS03
Entrez ID: 94227
|
Does Knockout of Rnf11 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Rnf11
|
cell cycle progression
|
breast epithelium
|
Gene: Rnf11 (ring finger protein 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein autoubiquitination, ubiquitin-dependent protein catabolic process; MF: metal ion binding, protein binding, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, early endosome, endosome, nucleus, recycling endosome, ubiquitin ligase complex
Pathways:
UniProt: Q9QYK7
Entrez ID: 29864
|
Does Knockout of Fam170b in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Fam170b
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Fam170b (family with sequence similarity 170, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fertilization, positive regulation of acrosome reaction, regulation of fertilization; CC: acrosomal vesicle, cytoplasmic vesicle, membrane, outer acrosomal membrane
Pathways:
UniProt: E9PXT9
Entrez ID: 105511
|
Does Knockout of Prlhr in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Prlhr
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Prlhr (prolactin releasing hormone receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, feeding behavior, hormone metabolic process, neuropeptide signaling pathway, signal transduction; MF: G protein-coupled receptor activity, neuropeptide Y receptor activity, neuropeptide binding, neuropeptide receptor activity, peptide hormone binding; CC: cilium, membrane, neuron projection, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q6VMN6
Entrez ID: 226278
|
Does Knockout of Sult5a1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Sult5a1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Sult5a1 (sulfotransferase family 5A, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: sulfotransferase activity, transferase activity; CC: cytoplasm
Pathways:
UniProt: Q3UQP7, Q91X36, D6RH78, D3Z6D1
Entrez ID: 57429
|
Does Knockout of Cdx2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Cdx2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cdx2 (caudal type homeobox 2)
Type: protein-coding
Summary: Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in intestinal epithelial cell differentiation; positive regulation of transcription by RNA polymerase II; and regulation of somitogenesis. Acts upstream of or within several processes, including endosome to lysosome transport; in utero embryonic development; and negative regulation of transcription by RNA polymerase II. Located in condensed nuclear chromosome. Part of transcription repressor complex. Is expressed in several structures, including central nervous system; early conceptus; embryo mesoderm; genitourinary system; and gut. Orthologous to human CDX2 (caudal type homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: anterior/posterior axis specification, anterior/posterior pattern specification, blastocyst development, blood vessel development, cell differentiation, digestive tract development, embryonic pattern specification, endosome to lysosome transport, establishment or maintenance of epithelial cell apical/basal polarity, intestinal epithelial cell differentiation, labyrinthine layer development, negative regulation of transcription by RNA polymerase II, pattern specification process, placenta development, positive regulation of DNA-templated transcription, positive regulation of cell differentiation, positive regulation of cell population proliferation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of somitogenesis, regulation of transcription by RNA polymerase II, somatic stem cell population maintenance, stem cell differentiation, trophectodermal cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, double-stranded DNA binding, methyl-CpG binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: condensed nuclear chromosome, nucleoplasm, nucleus, protein-containing complex, transcription repressor complex
Pathways: Gastric cancer - Mus musculus (mouse)
UniProt: P43241
Entrez ID: 12591
|
Does Knockout of Poln in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Poln
|
response to virus
|
Microglial Cell Line
|
Gene: Poln (DNA polymerase N)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA-templated DNA replication, double-strand break repair, double-strand break repair via homologous recombination, interstrand cross-link repair, translesion synthesis; MF: DNA binding, DNA polymerase activity, DNA-directed DNA polymerase activity, cyclin binding, nucleic acid binding, nucleotidyltransferase activity, transferase activity; CC: nucleoplasm, nucleus
Pathways: DNA Repair, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse)
UniProt: Q7TQ07
Entrez ID: 272158
|
Does Knockout of Akap7 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Akap7
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Akap7 (A kinase anchor protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: action potential, cAMP/PKA signal transduction, cell surface receptor protein serine/threonine kinase signaling pathway, cellular response to cAMP, intracellular protein localization, modulation of chemical synaptic transmission, positive regulation of potassium ion transmembrane transport, regulation of membrane repolarization; MF: AMP binding, nucleotide binding, protein binding, protein domain specific binding, protein kinase A binding, protein kinase A regulatory subunit binding, protein kinase binding; CC: T-tubule, apical plasma membrane, cytoplasm, cytosol, exocytic vesicle, hippocampal mossy fiber to CA3 synapse, lateral plasma membrane, nucleus, protein-containing complex, sarcoplasmic reticulum
Pathways:
UniProt: Q7TN79, O55074
Entrez ID: 432442
|
Does Knockout of Atrx in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Atrx
|
cell proliferation
|
Regulatory T cell
|
Gene: Atrx (ATRX, chromatin remodeler)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA repair, Sertoli cell development, cellular response to hydroxyurea, chromatin organization, chromatin remodeling, chromosome organization involved in meiotic cell cycle, developmental process involved in reproduction, forebrain development, gamete generation, meiotic spindle organization, multicellular organism growth, negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric, nucleosome assembly, positive regulation of nuclear cell cycle DNA replication, positive regulation of telomere maintenance, positive regulation of transcription by RNA polymerase II, post-embryonic forelimb morphogenesis, protein localization to chromosome, telomeric region, regulation of cell cycle process, regulation of chromosome organization, replication fork processing, seminiferous tubule development, spermatogenesis, subtelomeric heterochromatin formation; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA translocase activity, chromatin DNA binding, chromatin binding, chromo shadow domain binding, helicase activity, histone H3K9me2/3 reader activity, histone binding, hydrolase activity, metal ion binding, nucleotide binding, protein binding, zinc ion binding; CC: PML body, chromosome, chromosome, subtelomeric region, chromosome, telomeric region, condensed chromosome, centromeric region, heterochromatin, nuclear body, nuclear chromosome, nucleoplasm, nucleus, pericentric heterochromatin
Pathways: Cell Cycle, Chromosome Maintenance, Inhibition of DNA recombination at telomere, Telomere Maintenance
UniProt: Q61687
Entrez ID: 22589
|
Does Knockout of Ppp1r37 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Ppp1r37
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Ppp1r37 (protein phosphatase 1, regulatory subunit 37)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BKR5
Entrez ID: 232947
|
Does Knockout of Pus3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Pus3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Pus3 (pseudouridine synthase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA modification, mRNA pseudouridine synthesis, pseudouridine synthesis, tRNA processing, tRNA pseudouridine synthesis; MF: RNA binding, isomerase activity, pseudouridine synthase activity, tRNA pseudouridine(38/39) synthase activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9JI38
Entrez ID: 67049
|
Does Knockout of Rpl10a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Rpl10a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rpl10a (ribosomal protein L10A)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in several structures, including cerebral cortex; heart; immune system; liver; and lung. Orthologous to human RPL10A (ribosomal protein L10a). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, large ribosomal subunit, mitochondrion, postsynapse, postsynaptic density, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Ribosome - Mus musculus (mouse)
UniProt: Q99JL6, Q5XJF6, A0A3B2W820, A0A3B2W824, A0A3B2WCA5, A0A3B2WBL1, D6RE43, A0A3B2WDD2
Entrez ID: 19896
|
Does Knockout of Cecr2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Cecr2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Cecr2 (CECR2, histone acetyl-lysine reader)
Type: protein-coding
Summary: Predicted to enable ATP-dependent chromatin remodeler activity. Acts upstream of or within inner ear development; primary neural tube formation; and single fertilization. Located in euchromatin and nucleus. Part of CERF complex. Is expressed in several structures, including extraembryonic component; genitourinary system; and olfactory epithelium. Used to study anencephaly. Orthologous to human CECR2 (CECR2 histone acetyl-lysine reader). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chromatin organization, chromatin remodeling, cochlea development, execution phase of apoptosis, inner ear receptor cell stereocilium organization, neural fold formation, neural tube closure, neural tube development, single fertilization; MF: ATP-dependent chromatin remodeler activity, protein binding; CC: CERF complex, ISWI-type complex, euchromatin, nucleus
Pathways:
UniProt: E9Q2Z1
Entrez ID: 330409
|
Does Knockout of Gmppa in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Gmppa
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Gmppa (GDP-mannose pyrophosphorylase A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GDP-mannose biosynthetic process, GDP-mannose metabolic process, cognition, glycoprotein metabolic process, motor behavior, muscle organ morphogenesis, negative regulation of biosynthetic process, negative regulation of nucleobase-containing compound metabolic process, negative regulation of phosphate metabolic process, negative regulation of small molecule metabolic process, neuromuscular process, neuron apoptotic process, protein glycosylation, skeletal muscle organ development, telencephalon development; MF: enzyme binding, enzyme inhibitor activity, enzyme regulator activity, molecular sensor activity, molecular_function, transferase activity; CC: GDP-mannose pyrophosphorylase complex, cytoplasm, cytosol
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Fructose and mannose metabolism - Mus musculus (mouse), GDP-mannose biosynthesis, GDP-mannose biosynthesis I, GDP-mannose metabolism, Metabolism of proteins, Post-translational protein modification, Synthesis of GDP-mannose, Synthesis of substrates in N-glycan biosythesis, colanic acid building blocks biosynthesis
UniProt: Q922H4
Entrez ID: 69080
|
Does Knockout of Mapk11 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Mapk11
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mapk11 (mitogen-activated protein kinase 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, NLRP1 inflammasome complex assembly, bone development, cellular response to UV-B, cellular response to interleukin-1, cellular response to virus, intracellular signal transduction, negative regulation of cardiac muscle cell proliferation, osteoblast differentiation, p38MAPK cascade, positive regulation of gene expression, positive regulation of interleukin-12 production, protein maturation, pyroptotic inflammatory response, regulation of cardiac muscle cell proliferation, stress-activated MAPK cascade, stress-activated protein kinase signaling cascade; MF: ATP binding, MAP kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Activation of the AP-1 family of transcription factors, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Developmental Biology, Diabetic cardiomyopathy - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), ERK/MAPK targets, Epstein-Barr virus infection - Mus musculus (mouse), Fc epsilon RI signaling pathway - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), G1/S DNA Damage Checkpoints, Gene expression (Transcription), Generic Transcription Pathway, GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Innate Immune System, Interleukin-17 signaling, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAP kinase activation, MAPK signaling pathway - Mus musculus (mouse), MAPK targets/ Nuclear events mediated by MAP kinases, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Myogenesis, NOD-like receptor signaling pathway - Mus musculus (mouse), NOD1/2 Signaling Pathway, Neurotrophin signaling pathway - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Nuclear Events (kinase and transcription factor activation), Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Oocyte meiosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Oxidative Stress Induced Senescence, PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Progesterone-mediated oocyte maturation - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases Activate NADPH Oxidases, RIG-I-like receptor signaling pathway - Mus musculus (mouse), RNA Polymerase II Transcription, Rap1 signaling pathway - Mus musculus (mouse), Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Relaxin signaling pathway - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Interleukins, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Signalling to ERKs, Signalling to RAS, Sphingolipid signaling pathway - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Transcriptional Regulation by TP53, Tuberculosis - Mus musculus (mouse), Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, VEGF signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, Yersinia infection - Mus musculus (mouse), activated TAK1 mediates p38 MAPK activation, p38MAPK events, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9WUI1
Entrez ID: 19094
|
Does Knockout of Nrtn in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Nrtn
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Nrtn (neurturin)
Type: protein-coding
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. Homozygous knockout mice for this gene exhibit defects in the development of the retina and enteric nervous system, and reduced cholinergic innervation of the heart and lacrimal glands. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: cell surface receptor protein tyrosine kinase signaling pathway, cell surface receptor signaling pathway via STAT, glial cell-derived neurotrophic factor receptor signaling pathway, nerve development, nervous system development, neural crest cell migration, neuron projection development; MF: glial cell-derived neurotrophic factor receptor binding, growth factor activity, heparan sulfate binding, receptor tyrosine kinase binding; CC: axon, extracellular region, extracellular space
Pathways: Axon guidance, Developmental Biology, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Nervous system development, RAF/MAP kinase cascade, RET signaling, Signal Transduction
UniProt: P97463
Entrez ID: 18188
|
Does Knockout of Fads2 in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Fads2
|
response to bacteria
|
macrophage
|
Gene: Fads2 (fatty acid desaturase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alpha-linolenic acid metabolic process, arachidonate metabolite production involved in inflammatory response, fatty acid biosynthetic process, fatty acid derivative biosynthetic process, fatty acid metabolic process, linoleic acid metabolic process, lipid metabolic process, long-chain fatty acid biosynthetic process, positive regulation of cellular response to oxidative stress, unsaturated fatty acid biosynthetic process; MF: acyl-CoA 6-desaturase activity, acyl-CoA desaturase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water, stearoyl-CoA 9-desaturase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid metabolism, Linoleic acid (LA) metabolism, Metabolism, Metabolism of lipids, PPAR signaling pathway - Mus musculus (mouse), alpha-Linolenic acid metabolism - Mus musculus (mouse), alpha-linolenic (omega3) and linoleic (omega6) acid metabolism, alpha-linolenic acid (ALA) metabolism, oleate biosynthesis II (animals)
UniProt: Q9Z0R9
Entrez ID: 56473
|
Does Knockout of Adra2c in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Adra2c
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Adra2c (adrenergic receptor, alpha 2c)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, adrenergic receptor signaling pathway, epidermal growth factor receptor signaling pathway, female pregnancy, negative regulation of norepinephrine secretion, negative regulation of uterine smooth muscle contraction, platelet activation, positive regulation of MAPK cascade, positive regulation of neuron differentiation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of vasoconstriction, regulation of smooth muscle contraction, regulation of vasoconstriction, signal transduction; MF: G protein-coupled receptor activity, adrenergic receptor activity, alpha-2A adrenergic receptor binding, alpha2-adrenergic receptor activity, epinephrine binding, protein heterodimerization activity, protein homodimerization activity; CC: axon, axon terminus, cytoplasm, glutamatergic synapse, membrane, neuronal cell body, plasma membrane, postsynaptic density membrane, postsynaptic membrane
Pathways: Adrenaline signalling through Alpha-2 adrenergic receptor, Adrenaline,noradrenaline inhibits insulin secretion, Adrenoceptors, Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, G alpha (z) signalling events, GPCR downstream signalling, GPCR ligand binding, Hemostasis, Integration of energy metabolism, Metabolism, Metabolism of proteins, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Platelet Aggregation (Plug Formation), Platelet activation, signaling and aggregation, Regulation of insulin secretion, Signal Transduction, Signaling by GPCR, Surfactant metabolism, cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: Q01337
Entrez ID: 11553
|
Does Knockout of Amy1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Amy1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Amy1 (amylase 1, salivary)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, response to bacterium; MF: alpha-amylase activity, amylase activity, calcium ion binding, catalytic activity, cation binding, chloride ion binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, metal ion binding; CC: extracellular region, extracellular space
Pathways: Carbohydrate digestion and absorption - Mus musculus (mouse), Pancreatic secretion - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Starch and sucrose metabolism - Mus musculus (mouse), starch degradation
UniProt: P00687
Entrez ID: 11722
|
Does Knockout of Bnip2 in Microglial Cell Line causally result in response to virus?
| 0
| 1,438
|
Knockout
|
Bnip2
|
response to virus
|
Microglial Cell Line
|
Gene: Bnip2 (BCL2/adenovirus E1B interacting protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, blastocyst development, centrosome cycle, positive regulation of MAPK cascade, positive regulation of neuron differentiation, positive regulation of small GTPase mediated signal transduction, response to oxygen-glucose deprivation, striated muscle cell differentiation; CC: centriole, cytoplasm, cytosol, intracellular membrane-bounded organelle, nuclear envelope, nucleolus, perinuclear region of cytoplasm, spindle pole centrosome
Pathways: Developmental Biology, Myogenesis
UniProt: O54940
Entrez ID: 12175
|
Does Knockout of Ada in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Ada
|
phagocytosis
|
macrophage
|
Gene: Ada (adenosine deaminase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: AMP catabolic process, AMP salvage, GMP salvage, IMP salvage, Peyer's patch development, T cell activation, adenosine catabolic process, adenosine metabolic process, allantoin metabolic process, amide catabolic process, cell adhesion, dAMP catabolic process, dATP catabolic process, deoxyadenosine catabolic process, embryonic digestive tract development, germinal center B cell differentiation, histamine secretion, hypoxanthine biosynthetic process, hypoxanthine salvage, in utero embryonic development, inhibition of non-skeletal tissue mineralization, inosine biosynthetic process, liver development, lung alveolus development, lung development, negative regulation of adenosine receptor signaling pathway, negative regulation of apoptotic process, negative regulation of circadian sleep/wake cycle, non-REM sleep, negative regulation of inflammatory response, negative regulation of leukocyte migration, negative regulation of mature B cell apoptotic process, negative regulation of mucus secretion, negative regulation of penile erection, negative regulation of thymocyte apoptotic process, nucleotide metabolic process, placenta development, positive regulation of B cell proliferation, positive regulation of T cell activation, positive regulation of T cell differentiation, positive regulation of T cell differentiation in thymus, positive regulation of T cell receptor signaling pathway, positive regulation of alpha-beta T cell differentiation, positive regulation of calcium-mediated signaling, positive regulation of germinal center formation, positive regulation of heart rate, positive regulation of smooth muscle contraction, purine nucleotide salvage, purine ribonucleoside monophosphate biosynthetic process, regulation of T cell differentiation, regulation of T cell differentiation in thymus, regulation of cell-cell adhesion mediated by integrin, regulation of circadian sleep/wake cycle, sleep, response to hypoxia, response to purine-containing compound, response to vitamin E, trophectodermal cell differentiation, xanthine biosynthetic process; MF: 2'-deoxyadenosine deaminase activity, adenosine deaminase activity, deaminase activity, hydrolase activity, metal ion binding, purine nucleoside binding, zinc ion binding; CC: anchoring junction, cell surface, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle lumen, cytosol, dendrite cytoplasm, external side of plasma membrane, extracellular space, lysosome, membrane, neuronal cell body, plasma membrane
Pathways: Drug ADME, Metabolism, Metabolism of nucleotides, Nucleotide salvage, Primary immunodeficiency - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Purine salvage, Ribavirin ADME, adenine and adenosine salvage III, adenosine nucleotides degradation II, purine nucleotides degradation II (aerobic), purine ribonucleosides degradation to ribose-1-phosphate
UniProt: P03958
Entrez ID: 11486
|
Does Knockout of Hs1bp3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Hs1bp3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Hs1bp3 (HCLS1 binding protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell differentiation, cell surface receptor signaling pathway, regulation of apoptotic process; MF: phosphatidylinositol binding, protein binding; CC: endoplasmic reticulum, mitochondrion
Pathways:
UniProt: Q3TC93
Entrez ID: 58240
|
Does Knockout of Nsun5 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Nsun5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nsun5 (NOL1/NOP2/Sun domain family, member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA methylation, cerebral cortex development, cognition, corpus callosum development, methylation, oligodendrocyte development, positive regulation of translation, rRNA base methylation, rRNA processing, regulation of myelination; MF: RNA binding, RNA methyltransferase activity, methyltransferase activity, rRNA (cytosine-C5-)-methyltransferase activity, transferase activity; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8K4F6
Entrez ID: 100609
|
Does Knockout of Syna in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Syna
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Syna (syncytin a)
Type: protein-coding
Summary: Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of a mouse endogenous retrovirus provirus on chromosome 5 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: labyrinthine layer development, myoblast fusion, syncytium formation, syncytium formation by plasma membrane fusion; CC: membrane, plasma membrane
Pathways:
UniProt: Q5G5D5
Entrez ID: 214292
|
Does Knockout of Trappc13 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Trappc13
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Trappc13 (trafficking protein particle complex 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle coating, vesicle tethering; CC: TRAPPII protein complex, TRAPPIII protein complex, cytoplasm
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q3TIR1
Entrez ID: 66975
|
Does Knockout of Col6a1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Col6a1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Col6a1 (collagen, type VI, alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 2-oxoglutarate metabolic process, adipose tissue development, anatomical structure morphogenesis, apoptotic nuclear changes, apoptotic process, autophagy, basement membrane organization, bone development, bone mineralization, canonical Wnt signaling pathway, cartilage development, caveola assembly, cell adhesion, cell differentiation, cell morphogenesis, cellular response to amino acid stimulus, circadian rhythm, collagen fibril organization, collagen metabolic process, endodermal cell differentiation, energy homeostasis, energy reserve metabolic process, extracellular matrix assembly, fat cell proliferation, gene expression, glycolytic process, hair follicle development, heart development, homeostasis of number of cells, inflammatory response, insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, limb joint morphogenesis, lung alveolus development, lung development, lung epithelial cell differentiation, lung morphogenesis, mitochondrial depolarization, mitochondrial transmembrane transport, mitochondrion organization, multicellular organismal locomotion, muscle cell apoptotic process, muscle cell development, muscle organ development, muscle structure development, muscle system process, myelination in peripheral nervous system, nervous system process, neuron apoptotic process, ossification, peripheral nervous system development, phosphatidylinositol 3-kinase/protein kinase B signal transduction, protein tetramerization, reactive oxygen species metabolic process, reduction of food intake in response to dietary excess, regulation of cell size, regulation of collagen fibril organization, respiratory system process, response to UV, response to activity, response to bleomycin, response to decreased oxygen levels, response to lipid, response to lipopolysaccharide, response to mechanical stimulus, response to muscle activity, response to pain, response to peptide, response to polyamine macromolecule, response to reactive oxygen species, response to toxic substance, response to wounding, response to xenobiotic stimulus, sensory perception of mechanical stimulus, single fertilization, skeletal muscle fiber development, skeletal muscle fiber differentiation, skeletal muscle organ development, skeletal muscle tissue development, skeletal muscle tissue growth, skeletal muscle tissue regeneration, skin development, tissue development, tissue remodeling, transmission of nerve impulse, tricarboxylic acid cycle, uterus development; MF: collagen binding, extracellular matrix structural constituent conferring tensile strength, platelet-derived growth factor binding, protein binding; CC: basement membrane, collagen trimer, collagen type VI trimer, endoplasmic reticulum, extracellular matrix, extracellular region, extracellular space, intracellular vesicle, lysosome, mitochondrion, myofibril, protein-containing complex, sarcolemma, sarcoplasmic reticulum
Pathways: Assembly of collagen fibrils and other multimeric structures, Axon guidance, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen degradation, Collagen formation, Degradation of the extracellular matrix, Developmental Biology, ECM proteoglycans, ECM-receptor interaction - Mus musculus (mouse), Extracellular matrix organization, Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Integrin cell surface interactions, NCAM signaling for neurite out-growth, NCAM1 interactions, Nervous system development, PI3K-Akt signaling pathway - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse), Signal Transduction, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases
UniProt: Q04857
Entrez ID: 12833
|
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