prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Cdk2ap2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Cdk2ap2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cdk2ap2 (cyclin dependent kinase 2 associated protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of G1/S transition of mitotic cell cycle, regulation of microtubule cytoskeleton organization, regulation of stem cell division; CC: NuRD complex, cytoplasm, microtubule, nucleus
Pathways:
UniProt: Q9CPY4
Entrez ID: 52004
|
Does Knockout of Ecscr in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Ecscr
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ecscr (endothelial cell surface expressed chemotaxis and apoptosis regulator)
Type: protein-coding
Summary: Acts upstream of or within negative regulation of angiogenesis. Located in cytosol and plasma membrane. Is expressed in several structures, including cardiovascular system; gut; hemolymphoid system gland; male reproductive gland or organ; and respiratory system. Orthologous to human ECSCR (endothelial cell surface expressed chemotaxis and apoptosis regulator). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: angiogenesis, apoptotic process, cell differentiation, chemotaxis, negative regulation of angiogenesis, positive regulation of endothelial cell apoptotic process, positive regulation of proteasomal protein catabolic process; CC: cytoplasm, cytosol, membrane, nucleoplasm, plasma membrane
Pathways:
UniProt: Q3TZW0
Entrez ID: 68545
|
Does Knockout of Racgap1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,263
|
Knockout
|
Racgap1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Racgap1 (Rac GTPase-activating protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, actomyosin contractile ring assembly, cell differentiation, cell division, erythrocyte differentiation, mitotic cytokinesis, mitotic spindle midzone assembly, monoatomic ion transport, neuroblast proliferation, positive regulation of cytokinesis, regulation of attachment of spindle microtubules to kinetochore, regulation of embryonic development, signal transduction, spermatogenesis, sulfate transmembrane transport; MF: GTPase activator activity, alpha-tubulin binding, beta-tubulin binding, gamma-tubulin binding, lipid binding, metal ion binding, microtubule binding, phosphatidylinositol-3,4,5-trisphosphate binding, protein kinase binding, protein-macromolecule adaptor activity, zinc ion binding; CC: Flemming body, acrosomal vesicle, centralspindlin complex, cleavage furrow, cytoplasm, cytoplasmic side of plasma membrane, cytoplasmic vesicle, cytoskeleton, membrane, midbody, mitotic spindle, nucleoplasm, nucleus, plasma membrane, spindle, spindle midzone
Pathways: Adaptive Immune System, CDC42 GTPase cycle, COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, MHC class II antigen presentation, Membrane Trafficking, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport
UniProt: Q9WVM1
Entrez ID: 26934
|
Does Knockout of Adhfe1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,279
|
Knockout
|
Adhfe1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Adhfe1 (alcohol dehydrogenase, iron containing, 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-glutamate catabolic process via 2-hydroxyglutarate, lipid metabolic process; MF: alcohol dehydrogenase (NAD+) activity, hydroxyacid-oxoacid transhydrogenase activity, metal ion binding, oxidoreductase activity; CC: mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Interconversion of 2-oxoglutarate and 2-hydroxyglutarate, Metabolism
UniProt: Q8R0N6
Entrez ID: 76187
|
Does Knockout of Zfp617 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Zfp617
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Zfp617 (zinc finger protein 617)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: D3Z0X4, Q91WM0
Entrez ID: 170938
|
Does Knockout of Magee2 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Magee2
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Magee2 (MAGE family member E2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, brain morphogenesis, negative regulation of transcription by RNA polymerase II
Pathways:
UniProt: Q8CBC3, Q52KG3
Entrez ID: 272790
|
Does Knockout of Plekhj1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Plekhj1
|
cell proliferation
|
Regulatory T cell
|
Gene: Plekhj1 (pleckstrin homology domain containing, family J member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endosome organization, receptor recycling, retrograde transport, endosome to Golgi; CC: cytosol, early endosome, recycling endosome, trans-Golgi network
Pathways:
UniProt: Q9D240
Entrez ID: 78670
|
Does Knockout of Fhit in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Fhit
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Fhit (fragile histidine triad gene)
Type: protein-coding
Summary: This gene encodes a member of the HIT family of proteins that are characterized by the presence of a histidine triad sequence. The encoded protein is a diadenosine triphosphate hydrolase enzyme that cleaves the P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. This locus is very fragile and has been found to be altered in different types of cancers. Mice lacking the encoded protein display increased susceptibility to spontaneous and induced tumors. Ectopic expression of the encoded protein in such knockout mice inhibits tumor development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: DNA replication, apoptotic process, diadenosine triphosphate catabolic process, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, purine nucleotide metabolic process; MF: adenosine 5'-monophosphoramidase activity, adenylylsulfatase activity, adenylylsulfate-ammonia adenylyltransferase activity, bis(5'-adenosyl)-triphosphatase activity, catalytic activity, hydrolase activity, identical protein binding, nickel cation binding, nucleotide binding, transferase activity, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, fibrillar center, mitochondrion, nucleus, plasma membrane
Pathways: Non-small cell lung cancer - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse)
UniProt: O89106
Entrez ID: 14198
|
Does Knockout of Dmd in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Dmd
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Dmd (dystrophin, muscular dystrophy)
Type: protein-coding
Summary: This gene encodes a large, rod-like cytoskeletal protein which is found at the inner surface of muscle fibers in skeletal and cardiac muscles. The encoded protein, dystrophin, is part of the dystrophin-glycoprotein complex, which bridges the inner cytoskeleton (F-actin) and the extra-cellular matrix. This protein is required for proper development and organization of myofibers as contractile units in striated muscles. Mutations in the human gene cause Duchenne and Becker Muscular Dystrophies and a form of heart disease called DMD-associated dilated cardiomyopathy. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: apoptotic process, bone development, cardiac muscle cell action potential, cardiac muscle contraction, cell differentiation, cerebral cortex development, connective tissue development, determination of adult lifespan, establishment of blood-nerve barrier, establishment of glial blood-brain barrier, gene expression, inflammatory response, intracellular protein localization, limb development, multicellular organism growth, muscle cell cellular homeostasis, muscle cell development, muscle cell differentiation, muscle organ development, myotube cell development, negative regulation of ERK1 and ERK2 cascade, negative regulation of neuron differentiation, neuron development, neuron differentiation, neuron projection morphogenesis, nucleus localization, olfactory nerve structural organization, peptide biosynthetic process, positive regulation of cell population proliferation, positive regulation of cell-matrix adhesion, positive regulation of neuron differentiation, positive regulation of neuron projection development, protein-containing complex assembly, reactive oxygen species biosynthetic process, regulation of DNA-templated transcription, regulation of calcium ion transmembrane transport, regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, regulation of cellular response to growth factor stimulus, regulation of gene expression, regulation of heart rate, regulation of membrane potential, regulation of muscle system process, regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, regulation of skeletal muscle contraction, regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion, regulation of sodium ion transmembrane transport, response to denervation involved in regulation of muscle adaptation, response to muscle stretch, response to xenobiotic stimulus, skeletal muscle tissue development, skeletal muscle tissue regeneration, striated muscle cell development, striated muscle contraction, synaptic signaling, synaptic transmission, cholinergic, walking behavior; MF: PDZ domain binding, actin binding, dystroglycan binding, integrin binding, lamin binding, metal ion binding, myosin binding, nitric-oxide synthase binding, protein binding, protein-containing complex binding, structural constituent of muscle, vinculin binding, zinc ion binding; CC: GABA-ergic synapse, Z disc, astrocyte projection, axon, cell junction, cell projection, cell surface, cell-substrate junction, costamere, cytoplasm, cytoskeleton, dystrophin-associated glycoprotein complex, filopodium, filopodium membrane, lamellipodium, matrix side of mitochondrial inner membrane, membrane, membrane raft, mitochondrial outer membrane, myofibril, neurofilament, neuron projection terminus, neuronal cell body, nucleus, perinuclear region of cytoplasm, plasma membrane, plasma membrane bounded cell projection, postsynapse, postsynaptic density, postsynaptic membrane, postsynaptic specialization, protein-containing complex, ribosome, sarcolemma, secretory granule, synapse, synaptic vesicle membrane
Pathways: Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Extracellular matrix organization, Formation of the dystrophin-glycoprotein complex (DGC), Hypertrophic cardiomyopathy - Mus musculus (mouse), Muscle contraction, Non-integrin membrane-ECM interactions, Striated Muscle Contraction, Viral myocarditis - Mus musculus (mouse)
UniProt: P11531
Entrez ID: 13405
|
Does Knockout of Sh2d2a in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Sh2d2a
|
phagocytosis
|
macrophage
|
Gene: Sh2d2a (SH2 domain containing 2A)
Type: protein-coding
Summary: Predicted to enable protein-macromolecule adaptor activity. Acts upstream of or within T cell proliferation. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in juvenile rheumatoid arthritis and multiple sclerosis. Orthologous to human SH2D2A (SH2 domain containing 2A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: SH3 domain binding, protein binding; CC: cytoplasm, membrane, plasma membrane
Pathways: Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, VEGF signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway
UniProt: Q9QXK9
Entrez ID: 27371
|
Does Knockout of 1700013G24Rik in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
1700013G24Rik
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: 1700013G24Rik (RIKEN cDNA 1700013G24 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9DAC6
Entrez ID: 69380
|
Does Knockout of Pabpn1l in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Pabpn1l
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Pabpn1l (poly(A)binding protein nuclear 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maternal-to-zygotic transition of gene expression, negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process, negative regulation of protein ubiquitination, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; MF: RNA binding, nucleic acid binding, poly(A) binding, protein binding; CC: cytoplasm, cytosol, nucleus
Pathways: Influenza A - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q5XFR0
Entrez ID: 382035
|
Does Knockout of Aamp in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Aamp
|
cell cycle progression
|
breast epithelium
|
Gene: Aamp (angio-associated migratory protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cell surface, cytoplasm, intercellular bridge, microtubule cytoskeleton, plasma membrane
Pathways: Hemostasis, Immune System, Innate Immune System, NOD1/2 Signaling Pathway, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Platelet activation, signaling and aggregation, Signal Transduction, Signal amplification, Signaling by EGFR, Signaling by Receptor Tyrosine Kinases, Thromboxane signalling through TP receptor
UniProt: J3QN89, Q3TJ22, A0A087WR11, A0A087WNM5
Entrez ID: 227290
|
Does Knockout of Flii in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Flii
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Flii (flightless I actin binding protein)
Type: protein-coding
Summary: This gene encodes a protein with gelsolin-like repeats and an N-terminal leucine-rich repeat domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. This protein may act as an actin-remodelling protein as well as a transcriptional coactivator. Homozygous knockout mice show embryonic lethality. This protein may act to regulate wound repair. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: actin cytoskeleton organization, actin filament severing, actin polymerization or depolymerization, barbed-end actin filament capping, myofibril assembly, sarcomere organization; MF: actin binding, actin filament binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding; CC: actin cytoskeleton, anchoring junction, brush border, cell projection, centriolar satellite, centrosome, cytoplasm, cytoskeleton, cytosol, focal adhesion, nucleoplasm, nucleus, podosome
Pathways:
UniProt: Q9JJ28
Entrez ID: 14248
|
Does Knockout of Efcab5 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Efcab5
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Efcab5 (EF-hand calcium binding domain 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: calcium ion binding, metal ion binding, molecular_function
Pathways:
UniProt: A0JP43
Entrez ID: 319634
|
Does Knockout of Arsa in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Arsa
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Arsa (arylsulfatase A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, binding of sperm to zona pellucida, lipid metabolic process, response to estrogen, response to ethanol, response to methylmercury, response to nutrient, response to pH; MF: arylsulfatase activity, calcium ion binding, cerebroside-sulfatase activity, hydrolase activity, metal ion binding, sulfuric ester hydrolase activity; CC: acrosomal vesicle, endoplasmic reticulum, endosome, extracellular space, extrinsic component of external side of plasma membrane, lysosome, membrane, plasma membrane
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Glycosphingolipid catabolism, Glycosphingolipid metabolism, Immune System, Innate Immune System, Lysosome - Mus musculus (mouse), Metabolism, Metabolism of lipids, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse), The activation of arylsulfatases
UniProt: P50428
Entrez ID: 11883
|
Does Knockout of Zc3hc1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Zc3hc1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Zc3hc1 (zinc finger, C3HC type 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, protein ubiquitination; MF: metal ion binding, protein kinase binding, zinc ion binding; CC: nuclear envelope, nuclear membrane, nuclear pore nuclear basket, nucleoplasm, nucleus
Pathways:
UniProt: Q80YV2
Entrez ID: 232679
|
Does Knockout of Yrdc in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Yrdc
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Yrdc (yrdC domain containing (E.coli))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transport, regulation of translational fidelity, tRNA threonylcarbamoyladenosine modification; MF: L-threonylcarbamoyladenylate synthase, double-stranded RNA binding, nucleotidyltransferase activity, protein binding, tRNA binding, transferase activity; CC: cytoplasm, membrane, mitochondrion, plasma membrane
Pathways: Metabolism of RNA, tRNA modification in the mitochondrion, tRNA processing
UniProt: Q3U5F4
Entrez ID: 230734
|
Does Knockout of Rasef in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Rasef
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rasef (RAS and EF hand domain containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: vesicle-mediated transport, zymogen granule exocytosis; MF: GDP binding, GTP binding, GTPase activity, identical protein binding, nucleotide binding; CC: Golgi apparatus, cytoplasm, cytosol, early endosome, endolysosome, perinuclear region of cytoplasm
Pathways:
UniProt: Q5RI75
Entrez ID: 242505
|
Does Knockout of 2300009A05Rik in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
2300009A05Rik
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: 2300009A05Rik (RIKEN cDNA 2300009A05 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, extracellular region
Pathways:
UniProt: Q0VG49
Entrez ID: 69478
|
Does Knockout of Mtfmt in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Mtfmt
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mtfmt (mitochondrial methionyl-tRNA formyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: conversion of methionyl-tRNA to N-formyl-methionyl-tRNA, translation, translational initiation; MF: methionyl-tRNA formyltransferase activity, transferase activity; CC: mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), One carbon pool by folate - Mus musculus (mouse)
UniProt: Q9D799
Entrez ID: 69606
|
Does Knockout of Cdkn2b in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Cdkn2b
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Cdkn2b (cyclin dependent kinase inhibitor 2B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to cell-matrix adhesion, cellular response to nutrient, cellular senescence, megakaryocyte differentiation, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of cell cycle, negative regulation of cell cycle G1/S phase transition, negative regulation of cell population proliferation, negative regulation of epithelial cell proliferation, negative regulation of glial cell proliferation, positive regulation of transforming growth factor beta receptor signaling pathway, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, spleen development, transforming growth factor beta receptor signaling pathway; MF: MDM2/MDM4 family protein binding, NF-kappaB binding, RNA polymerase II-specific DNA-binding transcription factor binding, SUMO transferase activity, cyclin-dependent protein serine/threonine kinase inhibitor activity, disordered domain specific binding, ligase inhibitor activity, p53 binding, protein kinase binding, ubiquitin ligase inhibitor activity; CC: cytoplasm, mitochondrion, nuclear body, nucleolus, nucleoplasm, nucleus, protein-containing complex, senescence-associated heterochromatin focus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Cyclin D associated events in G1, FoxO signaling pathway - Mus musculus (mouse), G1 Phase, Gastric cancer - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Mitotic G1 phase and G1/S transition, Oncogene Induced Senescence, Oxidative Stress Induced Senescence, Pathways in cancer - Mus musculus (mouse), Senescence-Associated Secretory Phenotype (SASP), Small cell lung cancer - Mus musculus (mouse), TGF-beta signaling pathway - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: P55271
Entrez ID: 12579
|
Does Knockout of Ndufaf8 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Ndufaf8
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ndufaf8 (NADH:ubiquinone oxidoreductase complex assembly factor 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial respiratory chain complex I assembly; CC: mitochondrial matrix, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, Respiratory electron transport, Thermogenesis - Mus musculus (mouse)
UniProt: A2AMZ4
Entrez ID: 208501
|
Does Knockout of Gfra2 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Gfra2
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Gfra2 (glial cell line derived neurotrophic factor family receptor alpha 2)
Type: protein-coding
Summary: The protein encoded by this gene is part of the receptor complex that transduces glial cell-derived neurotrophic factor and neurturin signals by mediating autophosphorylation and activation of the RET receptor. Mice lacking this protein are viable and fertile but display growth retardation attributed to impaired salivary and pancreatic secretion and innervation deficits in the intestinal tract. In addition, knockout mice display neural defects including a failure to initiate outgrowth of dorsal ganglion root neurons, demonstrating a requirement in neuronal differentiation of these cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: cell surface receptor protein tyrosine kinase signaling pathway, glial cell-derived neurotrophic factor receptor signaling pathway, nervous system development, positive regulation of receptor signaling pathway via STAT; MF: glial cell-derived neurotrophic factor receptor activity, heparan sulfate binding, signaling receptor activity; CC: external side of plasma membrane, membrane, plasma membrane, receptor complex, side of membrane
Pathways: Axon guidance, Developmental Biology, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Nervous system development, RAF/MAP kinase cascade, RET signaling, Signal Transduction
UniProt: O08842
Entrez ID: 14586
|
Does Knockout of Lrrc4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Lrrc4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Lrrc4 (leucine rich repeat containing 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: excitatory synapse assembly, modulation of chemical synaptic transmission, postsynaptic density protein 95 clustering, synapse organization, synaptic membrane adhesion; MF: cell-cell adhesion mediator activity, protein binding; CC: Schaffer collateral - CA1 synapse, dendritic spine, excitatory synapse, glutamatergic synapse, membrane, neuron spine, plasma membrane, postsynaptic density membrane, postsynaptic membrane, synapse
Pathways: Axon guidance - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse)
UniProt: Q99PH1
Entrez ID: 192198
|
Does Knockout of Nphs1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Nphs1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Nphs1 (nephrosis 1, nephrin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: JNK cascade, MAPK cascade, cell adhesion, cell-cell adhesion, gene expression, glomerular basement membrane development, muscle organ development, myoblast fusion, podocyte development, positive regulation of actin filament polymerization, protein localization to synapse, skeletal muscle tissue development, slit diaphragm assembly; MF: alpha-actinin binding, cell adhesion molecule binding, myosin binding, protein binding, protein domain specific binding, spectrin binding; CC: basement membrane, cell periphery, cell projection, cell-cell junction, focal adhesion, membrane, plasma membrane, protein-containing complex, slit diaphragm
Pathways: Cell-Cell communication, Nephrin family interactions
UniProt: Q9QZS7
Entrez ID: 54631
|
Does Knockout of Zeb2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Zeb2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Zeb2 (zinc finger E-box binding homeobox 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: astrocyte activation, cell proliferation in forebrain, central nervous system development, collateral sprouting, corpus callosum morphogenesis, corticospinal tract morphogenesis, developmental pigmentation, embryonic morphogenesis, endothelial cell migration, endothelial cell proliferation, fibroblast activation, hippocampus development, mammillary axonal complex development, melanocyte migration, myofibroblast differentiation, negative regulation of fibroblast migration, negative regulation of transcription by RNA polymerase II, neural crest cell migration, neural tube closure, positive regulation of Wnt signaling pathway, positive regulation of axonogenesis, positive regulation of canonical Wnt signaling pathway, positive regulation of lens fiber cell differentiation, positive regulation of melanin biosynthetic process, positive regulation of melanocyte differentiation, positive regulation of myofibroblast contraction, positive regulation of transcription by RNA polymerase II, positive regulation of transforming growth factor beta receptor signaling pathway, pyroptotic inflammatory response, regulation of blood-brain barrier permeability, regulation of melanosome organization, regulation of myofibroblast cell apoptotic process, regulation of transcription by RNA polymerase II, response to oxygen-glucose deprivation, somitogenesis, stress fiber assembly; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, R-SMAD binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: chromatin, chromosome, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, MicroRNAs in cancer - Mus musculus (mouse), Regulation of CDH11 Expression and Function, Regulation of CDH11 gene transcription, Regulation of Expression and Function of Type II Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion
UniProt: Q9R0G7
Entrez ID: 24136
|
Does Knockout of Kcnb1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Kcnb1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Kcnb1 (potassium voltage gated channel, Shab-related subfamily, member 1)
Type: protein-coding
Summary: Enables delayed rectifier potassium channel activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of insulin secretion; and positive regulation of long-term synaptic depression. Located in dendrite and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is expressed in several structures, including adipose tissue; brain; cardiovascular system; genitourinary system; and gut. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 26 and epilepsy. Orthologous to human KCNB1 (potassium voltage-gated channel subfamily B member 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: action potential, cellular response to calcium ion, cellular response to glucose stimulus, cellular response to nutrient levels, clustering of voltage-gated potassium channels, exocytosis, glucose homeostasis, glutamate receptor signaling pathway, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of insulin secretion, positive regulation of calcium ion-dependent exocytosis, positive regulation of catecholamine secretion, positive regulation of long-term synaptic depression, positive regulation of norepinephrine secretion, positive regulation of protein targeting to membrane, potassium ion export across plasma membrane, potassium ion transmembrane transport, potassium ion transport, protein homooligomerization, protein localization to plasma membrane, regulation of action potential, regulation of motor neuron apoptotic process, response to L-glutamate, response to axon injury, transmembrane transport, vesicle docking involved in exocytosis; MF: SNARE binding, delayed rectifier potassium channel activity, monoatomic ion channel activity, outward rectifier potassium channel activity, potassium channel activity, potassium channel regulator activity, protein binding, protein heterodimerization activity, transmembrane transporter binding, voltage-gated potassium channel activity; CC: apical plasma membrane, axon, cell projection, cell surface, cholinergic synapse, dendrite, dendrite membrane, lateral plasma membrane, membrane, monoatomic ion channel complex, neuron projection, neuronal cell body, neuronal cell body membrane, perikaryon, perinuclear region of cytoplasm, plasma membrane, postsynaptic membrane, postsynaptic specialization membrane, proximal dendrite, sarcolemma, synapse, voltage-gated potassium channel complex
Pathways: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Integration of energy metabolism, Metabolism, Neuronal System, Potassium Channels, Regulation of insulin secretion, Voltage gated Potassium channels
UniProt: Q03717
Entrez ID: 16500
|
Does Knockout of Krtap19-4 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Krtap19-4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Krtap19-4 (keratin associated protein 19-4)
Type: protein-coding
Summary: Predicted to be located in cytosol and intermediate filament. Orthologous to human KRTAP19-3 (keratin associated protein 19-3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, cytosol, intermediate filament
Pathways: Developmental Biology, Keratinization
UniProt: Q925H7
Entrez ID: 170654
|
Does Knockout of Fgf15 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Fgf15
|
cell proliferation
|
Regulatory T cell
|
Gene: Fgf15 (fibroblast growth factor 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fibroblast growth factor receptor signaling pathway, heart development, negative regulation of bile acid biosynthetic process, negative regulation of gene expression, neural crest cell migration, neurogenesis, positive regulation of D-glucose import, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of MAPK cascade, positive regulation of cell population proliferation, regulation of cell migration, response to bacterium, response to ethanol; MF: fibroblast growth factor receptor binding, growth factor activity, protein binding; CC: cytoplasm, extracellular region, extracellular space
Pathways: Breast cancer - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Downstream signaling of activated FGFR4, FGFR4 ligand binding and activation, FRS-mediated FGFR4 signaling, Gastric cancer - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, Melanoma - Mus musculus (mouse), Negative regulation of FGFR4 signaling, Negative regulation of the PI3K/AKT network, PI-3K cascade:FGFR4, PI3K Cascade, PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pathways in cancer - Mus musculus (mouse), Phospholipase C-mediated cascade; FGFR4, RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), SHC-mediated cascade:FGFR4, Signal Transduction, Signaling by FGFR, Signaling by FGFR4, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), betaKlotho-mediated ligand binding
UniProt: O35622
Entrez ID: 14170
|
Does Knockout of 2310057J18Rik in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
2310057J18Rik
|
response to virus
|
Microglial Cell Line
|
Gene: 2310057J18Rik (RIKEN cDNA 2310057J18 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: extracellular region, extracellular space
Pathways:
UniProt: Q8C6C9
Entrez ID: 67719
|
Does Knockout of Bckdha in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Bckdha
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Bckdha (branched chain ketoacid dehydrogenase E1, alpha polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA, branched-chain amino acid catabolic process; MF: branched-chain 2-oxo acid dehydrogenase activity, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, protein-containing complex binding; CC: branched-chain alpha-ketoacid dehydrogenase complex, mitochondrial matrix, mitochondrion
Pathways: Leucine Catabolism, Propanoate metabolism - Mus musculus (mouse), Valine, leucine and isoleucine degradation - Mus musculus (mouse), branched-chain α-keto acid dehydrogenase complex, isoleucine degradation, valine degradation
UniProt: A0A0U1RPK5, Q3U3J1
Entrez ID: 12039
|
Does Knockout of Rnf182 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Rnf182
|
response to virus
|
Microglial Cell Line
|
Gene: Rnf182 (ring finger protein 182)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein ubiquitination; MF: metal ion binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, membrane
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q8C432
Entrez ID: 328234
|
Does Knockout of Tshb in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Tshb
|
response to bacteria
|
renal medulla cell line
|
Gene: Tshb (thyroid stimulating hormone, beta subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, extracellular region, extracellular space
Pathways: Autoimmune thyroid disease - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Regulation of lipolysis in adipocytes - Mus musculus (mouse), Thyroid hormone synthesis - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: E9Q4F3
Entrez ID: 22094
|
Does Knockout of Zfp449 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Zfp449
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Zfp449 (zinc finger protein 449)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of transcription by RNA polymerase II, spermatogonial cell division; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding
Pathways:
UniProt: Q8CB76
Entrez ID: 78619
|
Does Knockout of Prl8a2 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Prl8a2
|
phagocytosis
|
macrophage
|
Gene: Prl8a2 (prolactin family 8, subfamily a, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway, female pregnancy, mammary gland development, maternal process involved in female pregnancy, positive regulation of lactation, positive regulation of receptor signaling pathway via JAK-STAT, response to hypoxia, response to nutrient levels; MF: hormone activity, prolactin receptor binding; CC: extracellular region, extracellular space
Pathways:
UniProt: O54832, O35258, A0A286YDW1
Entrez ID: 13529
|
Does Knockout of Ccna1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Ccna1
|
phagocytosis
|
macrophage
|
Gene: Ccna1 (cyclin A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, cell differentiation, cell division, meiotic cell cycle, spermatogenesis; MF: cyclin-dependent protein serine/threonine kinase regulator activity, protein binding; CC: cyclin A1-CDK2 complex, cyclin A2-CDK2 complex, cytoplasm, cytoskeleton, microtubule cytoskeleton, microtubule organizing center, nucleus, spindle
Pathways: AMPK signaling pathway - Mus musculus (mouse), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of mitotic proteins, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Acute myeloid leukemia - Mus musculus (mouse), CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, Chromosome Maintenance, Cyclin A/B1/B2 associated events during G2/M transition, Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , DNA Damage/Telomere Stress Induced Senescence, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, Deubiquitination, Epstein-Barr virus infection - Mus musculus (mouse), Extension of Telomeres, G0 and Early G1, G1/S DNA Damage Checkpoints, G1/S Transition, G2 Phase, G2/M Checkpoints, G2/M DNA damage checkpoint, G2/M DNA replication checkpoint, G2/M Transition, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Hepatitis B - Mus musculus (mouse), Homology Directed Repair, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Metabolism of proteins, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Orc1 removal from chromatin, Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Processing of DNA double-strand break ends, Progesterone-mediated oocyte maturation - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Regulation of mitotic cell cycle, S Phase, SCF(Skp2)-mediated degradation of p27/p21, Senescence-Associated Secretory Phenotype (SASP), Switching of origins to a post-replicative state, Synthesis of DNA, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest, Telomere Extension By Telomerase, Telomere Maintenance, Transcriptional Regulation by TP53, Transcriptional misregulation in cancer - Mus musculus (mouse), Ub-specific processing proteases, Viral carcinogenesis - Mus musculus (mouse), p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint
UniProt: Q61456
Entrez ID: 12427
|
Does Knockout of Spata2 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Spata2
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Spata2 (spermatogenesis associated 2)
Type: protein-coding
Summary: Predicted to enable signaling receptor complex adaptor activity and ubiquitin-specific protease binding activity. Involved in protein linear deubiquitination; regulation of necroptotic process; and regulation of tumor necrosis factor-mediated signaling pathway. Acts upstream of or within seminiferous tubule development and spermatogenesis. Located in cytoplasm. Is expressed in several structures, including alimentary system; eye; genitourinary system; immune system; and nervous system. Orthologous to human SPATA2 (spermatogenesis associated 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: necroptotic process, programmed cell death, protein K63-linked deubiquitination, protein linear deubiquitination, regulation of inflammatory response, regulation of necroptotic process, regulation of tumor necrosis factor-mediated signaling pathway, seminiferous tubule development, spermatogenesis; MF: protein-containing complex binding, signaling receptor complex adaptor activity, ubiquitin-specific protease binding; CC: cytoplasm, fibrillar center, nucleoplasm, nucleus
Pathways: Necroptosis - Mus musculus (mouse)
UniProt: Q8K004
Entrez ID: 263876
|
Does Knockout of Slc6a6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Slc6a6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slc6a6 (solute carrier family 6 (neurotransmitter transporter, taurine), member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alanine transport, amino acid import across plasma membrane, amino acid transport, gamma-aminobutyric acid import, gamma-aminobutyric acid transport, import across plasma membrane, modulation of chemical synaptic transmission, neurotransmitter transport, positive regulation of cell differentiation, sodium ion transmembrane transport, taurine transmembrane transport; MF: alanine transmembrane transporter activity, amino acid transmembrane transporter activity, amino acid:sodium symporter activity, gamma-aminobutyric acid transmembrane transporter activity, gamma-aminobutyric acid:sodium:chloride symporter activity, symporter activity, taurine binding, taurine:sodium symporter activity; CC: GABA-ergic synapse, apical plasma membrane, basolateral plasma membrane, cell projection, dendrite, membrane, microvillus membrane, neuronal cell body, plasma membrane, plasma membrane protein complex, postsynaptic membrane
Pathways: Amino acid transport across the plasma membrane, SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Transport of small molecules
UniProt: O35316
Entrez ID: 21366
|
Does Knockout of Metrnl in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Metrnl
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Metrnl (meteorin, glial cell differentiation regulator-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brown fat cell differentiation, energy homeostasis, fat cell differentiation, negative regulation of inflammatory response, positive regulation of brown fat cell differentiation, response to cold, response to muscle activity, signal transduction; MF: hormone activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q8VE43
Entrez ID: 210029
|
Does Knockout of Rpl32 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Rpl32
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Rpl32 (ribosomal protein L32)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to dexamethasone stimulus, cytoplasmic translation, liver regeneration, translation, translation at postsynapse, translation at presynapse; MF: structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62911
Entrez ID: 19951
|
Does Knockout of Gtpbp3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 84
|
Knockout
|
Gtpbp3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gtpbp3 (GTP binding protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial tRNA wobble uridine modification, tRNA methylation, tRNA modification, tRNA processing, tRNA wobble uridine modification; MF: GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, tRNA 5-taurinomethyluridine synthase activity; CC: cytoplasm, mitochondrion, nucleus, transferase complex
Pathways:
UniProt: Q923K4
Entrez ID: 70359
|
Does Knockout of Zcchc13 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Zcchc13
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Zcchc13 (zinc finger, CCHC domain containing 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, mRNA binding, metal ion binding, nucleic acid binding, single-stranded RNA binding, translation regulator activity, zinc ion binding; CC: cytoplasm, endoplasmic reticulum, nucleus
Pathways:
UniProt: Q9D548
Entrez ID: 75064
|
Does Knockout of Snap29 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Snap29
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Snap29 (synaptosomal-associated protein 29)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome maturation, autophagosome membrane docking, autophagy, cell projection organization, cilium assembly, exocytosis, protein transport, regulation of synaptic vesicle cycle, regulation of synaptic vesicle exocytosis, synaptic vesicle fusion to presynaptic active zone membrane, synaptic vesicle priming; MF: SNAP receptor activity, syntaxin binding; CC: Golgi apparatus, Golgi membrane, SNARE complex, autophagosome, autophagosome membrane, cell projection, centrosome, ciliary membrane, ciliary pocket membrane, cilium, cytoplasm, cytoplasmic vesicle, cytosol, extrinsic component of synaptic vesicle membrane, membrane, plasma membrane, presynapse, synaptic vesicle
Pathways: Autophagy - animal - Mus musculus (mouse), Immune System, Innate Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Neutrophil degranulation, SNARE interactions in vesicular transport - Mus musculus (mouse), Vesicle-mediated transport
UniProt: Q9ERB0
Entrez ID: 67474
|
Does Knockout of Corin in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Corin
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Corin (corin, serine peptidase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: female pregnancy, neuron differentiation, peptide hormone processing, proteolysis, regulation of blood pressure, regulation of renal sodium excretion, regulation of systemic arterial blood pressure by atrial natriuretic peptide; MF: endopeptidase activity, hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: actin cytoskeleton, cell surface, cytoplasmic vesicle, extracellular region, membrane, nuclear body, plasma membrane
Pathways: Cardiac conduction, Muscle contraction, Physiological factors
UniProt: Q9Z319
Entrez ID: 53419
|
Does Knockout of Mtx1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,268
|
Knockout
|
Mtx1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Mtx1 (metaxin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrion organization, protein transport; CC: SAM complex, membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrion
Pathways:
UniProt: D3Z3F4, Q8R5C0, A0A6I8MWZ8, D3YVW0, G3UYJ5, G3UXB5, G3UXX9, G3UXP6, G3XA66, G3XA75
Entrez ID: 17827
|
Does Knockout of Fbln5 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Fbln5
|
cell cycle progression
|
breast epithelium
|
Gene: Fbln5 (fibulin 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, elastic fiber assembly, extracellular matrix organization, intramembranous bone growth, negative regulation of angiogenesis, negative regulation of transcription by RNA polymerase II, positive regulation of osteoblast proliferation, positive regulation of transcription by RNA polymerase II, protein localization to cell surface, regulation of removal of superoxide radicals, secretion; MF: calcium ion binding, extracellular matrix constituent conferring elasticity, integrin binding, protein binding, protein homodimerization activity; CC: elastic fiber, extracellular matrix, extracellular region, extracellular space
Pathways: Elastic fibre formation, Extracellular matrix organization, Molecules associated with elastic fibres
UniProt: Q9WVH9
Entrez ID: 23876
|
Does Knockout of 4933430I17Rik in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
4933430I17Rik
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: 4933430I17Rik (RIKEN cDNA 4933430I17 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BHW4, F6UZS4, Q14AX1
Entrez ID: 214106
|
Does Knockout of Cel in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Cel
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Cel (carboxyl ester lipase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide catabolic process, intestinal cholesterol absorption, lipid catabolic process, lipid metabolic process, pancreatic juice secretion, retinol metabolic process; MF: acetylesterase activity, carboxylic ester hydrolase activity, glycosphingolipid binding, hydrolase activity, phosphatidylcholine lysophospholipase activity, protein-containing complex binding, retinyl-palmitate esterase activity, sterol ester esterase activity, triacylglycerol lipase activity; CC: cytoplasm, extracellular region, extracellular space, membrane, protein-containing complex, zymogen granule
Pathways: Digestion, Digestion and absorption, Digestion of dietary lipid, Fat digestion and absorption - Mus musculus (mouse), Glycerolipid metabolism - Mus musculus (mouse), Pancreatic secretion - Mus musculus (mouse), Steroid biosynthesis - Mus musculus (mouse), triacylglycerol degradation
UniProt: Q64285
Entrez ID: 12613
|
Does Knockout of Rack1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Rack1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rack1 (receptor for activated C kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cellular response to glucose stimulus, cellular response to growth factor stimulus, gastrulation, intracellular protein localization, intracellular signal transduction, negative regulation of Wnt signaling pathway, negative regulation of cell growth, negative regulation of gene expression, negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide, negative regulation of phagocytosis, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of smoothened signaling pathway, negative regulation of translation, negative regulation of translational frameshifting, pigmentation, positive regulation of GTPase activity, positive regulation of Golgi to plasma membrane protein transport, positive regulation of amide metabolic process, positive regulation of apoptotic process, positive regulation of cell migration, positive regulation of gastrulation, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of lipid metabolic process, positive regulation of mitochondrial depolarization, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein phosphorylation, positive regulation of protein-containing complex assembly, protein ubiquitination, regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, regulation of cell cycle, regulation of cell division, regulation of establishment of cell polarity, regulation of membrane lipid metabolic process, regulation of protein localization, regulation of protein localization to plasma membrane, regulation of translation, rescue of stalled ribosome, rhythmic process, translation, tumor necrosis factor-mediated signaling pathway; MF: BH3 domain binding, SH2 domain binding, cyclin binding, cysteine-type endopeptidase activator activity involved in apoptotic process, enzyme activator activity, enzyme binding, identical protein binding, ion channel inhibitor activity, protein binding, protein homodimerization activity, protein kinase C binding, protein phosphatase binding, protein serine/threonine kinase inhibitor activity, protein tyrosine kinase inhibitor activity, receptor tyrosine kinase binding, ribosome binding, signaling adaptor activity, signaling receptor activity, translation regulator activity; CC: IRE1-RACK1-PP2A complex, cell body, cell projection, cytoplasm, cytosol, dendrite, membrane, midbody, mitochondrion, neuron projection, neuronal cell body, nucleoplasm, nucleus, perikaryon, perinuclear region of cytoplasm, phagocytic cup, plasma membrane, ribonucleoprotein complex, ribosome, small ribosomal subunit
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Death Receptor Signaling, Degradation of CDH1, Measles - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of TNFR1 signaling, Signal Transduction, TNF signaling, TNFR1-induced NF-kappa-B signaling pathway, TNFR1-mediated ceramide production
UniProt: P68040
Entrez ID: 14694
|
Does Knockout of Cox8a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Cox8a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cox8a (cytochrome c oxidase subunit 8A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial electron transport, cytochrome c to oxygen, oxidative phosphorylation; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, respiratory chain complex IV
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex IV assembly, Cytoprotection by HMOX1, Diabetic cardiomyopathy - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Mus musculus (mouse), Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), RNA Polymerase II Transcription, Respiratory electron transport, TP53 Regulates Metabolic Genes, Thermogenesis - Mus musculus (mouse), Transcriptional Regulation by TP53, aerobic respiration -- electron donor II
UniProt: Q64445
Entrez ID: 12868
|
Does Knockout of Nfyc in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Nfyc
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Nfyc (nuclear transcription factor-Y gamma)
Type: protein-coding
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Contributes to transcription cis-regulatory region binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; limb; molar; and nervous system. Orthologous to human NFYC (nuclear transcription factor Y subunit gamma). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein heterodimerization activity, transcription cis-regulatory region binding; CC: CCAAT-binding factor complex, RNA polymerase II transcription regulator complex, nucleoplasm, nucleus, protein-DNA complex, transcription regulator complex
Pathways: Antigen processing and presentation - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: P70353
Entrez ID: 18046
|
Does Knockout of Trim30a in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Trim30a
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Trim30a (tripartite motif-containing 30A)
Type: protein-coding
Summary: Predicted to enable several functions, including protein homodimerization activity; transcription coactivator activity; and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of cytokine production; protein autoubiquitination; and regulation of pattern recognition receptor signaling pathway. Acts upstream of or within response to bacterium. Located in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; heart; and limb. Orthologous to human TRIM5 (tripartite motif containing 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: activation of innate immune response, autophagy, host-mediated suppression of symbiont invasion, innate immune response, negative regulation of NLRP3 inflammasome complex assembly, negative regulation of interleukin-6 production, negative regulation of reactive oxygen species metabolic process, negative regulation of toll-like receptor signaling pathway, negative regulation of tumor necrosis factor production, positive regulation of MAPK cascade, positive regulation of canonical NF-kappaB signal transduction, positive regulation of protein catabolic process, positive regulation of viral entry into host cell, protein K63-linked ubiquitination, protein autoubiquitination, regulation of gene expression, regulation of lipopolysaccharide-mediated signaling pathway, regulation of protein localization, regulation of viral entry into host cell, response to bacterium, suppression of viral release by host; MF: DNA binding, identical protein binding, metal ion binding, pattern recognition receptor activity, protein homodimerization activity, protein kinase binding, protein-macromolecule adaptor activity, transcription coactivator activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: P-body, cytoplasm, nucleus, omegasome
Pathways:
UniProt: P15533
Entrez ID: 20128
|
Does Knockout of Pla2g12b in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Pla2g12b
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Pla2g12b (phospholipase A2, group XIIB)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate secretion, cholesterol homeostasis, lipid catabolic process, low-density lipoprotein particle remodeling, phospholipid metabolic process, triglyceride homeostasis; MF: calcium ion binding, metal ion binding, molecular_function, phospholipase A2 activity; CC: cellular_component, extracellular region
Pathways: Arachidonic acid metabolism - Mus musculus (mouse), Ether lipid metabolism - Mus musculus (mouse), Fat digestion and absorption - Mus musculus (mouse), Glycerophospholipid metabolism - Mus musculus (mouse), Linoleic acid metabolism - Mus musculus (mouse), Pancreatic secretion - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), alpha-Linolenic acid metabolism - Mus musculus (mouse), phospholipases
UniProt: F6UTM6, Q8VC81
Entrez ID: 69836
|
Does Knockout of Pim1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Pim1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Pim1 (proviral integration site 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cellular detoxification, cellular response to amino acid starvation, cellular response to nutrient levels, cellular response to type II interferon, cytolysis in another organism, defense response to bacterium, negative regulation of TORC1 signaling, negative regulation of apoptotic process, negative regulation of innate immune response, non-canonical inflammasome complex assembly, positive regulation of DNA-templated transcription, positive regulation of TORC1 signaling, positive regulation of brown fat cell differentiation, positive regulation of cardiac muscle cell proliferation, positive regulation of cardioblast proliferation, protein phosphorylation, protein stabilization, regulation of hematopoietic stem cell proliferation, regulation of mitotic cell cycle, regulation of transmembrane transporter activity, vitamin D receptor signaling pathway; MF: ATP binding, kinase activity, manganese ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity, ribosomal small subunit binding, transferase activity; CC: cytoplasm, cytosol, membrane, nucleolus, nucleoplasm, nucleus, plasma membrane
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Acute myeloid leukemia - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse)
UniProt: P06803
Entrez ID: 18712
|
Does Knockout of Cep135 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Cep135
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Cep135 (centrosomal protein 135)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: centriole replication, centriole-centriole cohesion, positive regulation of establishment of protein localization, positive regulation of non-motile cilium assembly; MF: identical protein binding, microtubule binding, protein homodimerization activity, tubulin binding; CC: centriole, centrosome, cytoplasm, cytoskeleton
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q6P5D4
Entrez ID: 381644
|
Does Knockout of Epcam in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Epcam
|
cell cycle progression
|
breast epithelium
|
Gene: Epcam (epithelial cell adhesion molecule)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell-cell adhesion, cell-cell adhesion via plasma-membrane adhesion molecules, negative regulation of apoptotic process, negative regulation of cell-cell adhesion mediated by cadherin, positive regulation of cell motility, positive regulation of cell population proliferation, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, signal transduction involved in regulation of gene expression, stem cell differentiation, ureteric bud development; MF: cadherin binding involved in cell-cell adhesion, protein-containing complex binding; CC: anchoring junction, apical plasma membrane, basolateral plasma membrane, bicellular tight junction, cell surface, lateral plasma membrane, membrane, plasma membrane
Pathways: Cell surface interactions at the vascular wall, Hemostasis
UniProt: Q99JW5
Entrez ID: 17075
|
Does Knockout of Mif in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Mif
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Mif (macrophage migration inhibitory factor (glycosylation-inhibiting factor))
Type: protein-coding
Summary: Enables cytokine activity; phenylpyruvate tautomerase activity; and protease binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of icosanoid secretion; and regulation of signal transduction. Acts upstream of or within DNA damage response, signal transduction by p53 class mediator; cellular senescence; and regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, signal transduction by p53 class mediator, carboxylic acid metabolic process, cell surface receptor signaling pathway, cellular senescence, immune system process, inflammatory response, innate immune response, negative regulation of DNA damage response, signal transduction by p53 class mediator, negative regulation of apoptotic process, negative regulation of cell migration, negative regulation of cellular senescence, negative regulation of gene expression, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of macrophage chemotaxis, negative regulation of mature B cell apoptotic process, negative regulation of myeloid cell apoptotic process, negative regulation of protein metabolic process, positive chemotaxis, positive regulation of B cell proliferation, positive regulation of ERK1 and ERK2 cascade, positive regulation of adaptive immune response, positive regulation of arachidonate secretion, positive regulation of cAMP/PKA signal transduction, positive regulation of cell population proliferation, positive regulation of chemokine (C-X-C motif) ligand 2 production, positive regulation of cytokine production, positive regulation of fibroblast proliferation, positive regulation of lipopolysaccharide-mediated signaling pathway, positive regulation of myeloid leukocyte cytokine production involved in immune response, positive regulation of phosphorylation, positive regulation of prostaglandin secretion involved in immune response, positive regulation of tumor necrosis factor production, prostaglandin biosynthetic process, protein homotrimerization, regulation of cell population proliferation, regulation of cellular response to stress; MF: chemoattractant activity, cytokine activity, cytokine receptor binding, dopachrome isomerase activity, identical protein binding, isomerase activity, phenylpyruvate tautomerase activity, protease binding, protein-containing complex binding; CC: cell surface, cytoplasm, cytosol, extracellular region, extracellular space, myelin sheath, nucleoplasm, plasma membrane
Pathways: Cell surface interactions at the vascular wall, Hemostasis, Immune System, Innate Immune System, Neutrophil degranulation, Phenylalanine metabolism - Mus musculus (mouse), Tyrosine metabolism - Mus musculus (mouse)
UniProt: P34884
Entrez ID: 17319
|
Does Knockout of Atg16l1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Atg16l1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Atg16l1 (autophagy related 16 like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagy, axonal transport, corpus callosum development, defense response to virus, dendrite arborization, hippocampus development, macroautophagy, microautophagy, negative regulation of dendrite extension, negative stranded viral RNA replication, positive regulation of autophagy, protein localization to phagophore assembly site, protein transport, xenophagy; MF: GTPase binding, identical protein binding, protein binding, protein-membrane adaptor activity; CC: Atg12-Atg5-Atg16 complex, autophagosome, autophagosome membrane, axon, axoneme, cytoplasm, cytosol, endolysosome membrane, endosome, endosome membrane, glutamatergic synapse, lysosomal membrane, lysosome, membrane, phagophore assembly site membrane, sperm midpiece, synapse, vacuole-isolation membrane contact site
Pathways: Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse)
UniProt: Q8C0J2
Entrez ID: 77040
|
Does Knockout of Col4a2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Col4a2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Col4a2 (collagen, type IV, alpha 2)
Type: protein-coding
Summary: This gene encodes the alpha-2 subunit of the type IV collagens, an essential component of basement membranes. The encoded protein forms a triple helical heterotrimer comprised of alpha-1 and alpha-2 subunits that assembles into a type IV collagen network. Canstatin, a peptide derived fom the C-terminus of the collagen chain, is a matrikine that has been shown to inhibit angiogenesis. Homozygous knockout mice for this gene exhibit impaired basement membrane integrity and embryonic lethality. This gene shares a bi-directional promoter with a related gene on chromosome 8. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: DNA-templated transcription, angiogenesis, cellular response to transforming growth factor beta stimulus, collagen-activated tyrosine kinase receptor signaling pathway, endodermal cell differentiation, negative regulation of angiogenesis, response to activity; MF: extracellular matrix structural constituent, extracellular matrix structural constituent conferring tensile strength, molecular adaptor activity; CC: basement membrane, collagen trimer, collagen type IV trimer, extracellular matrix, extracellular region, extracellular space
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Assembly of collagen fibrils and other multimeric structures, Axon guidance, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen degradation, Collagen formation, Crosslinking of collagen fibrils, Degradation of the extracellular matrix, Developmental Biology, ECM-receptor interaction - Mus musculus (mouse), Extracellular matrix organization, Fibronectin matrix formation, Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Integrin cell surface interactions, Laminin interactions, NCAM signaling for neurite out-growth, NCAM1 interactions, Nervous system development, Non-integrin membrane-ECM interactions, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Small cell lung cancer - Mus musculus (mouse)
UniProt: P08122
Entrez ID: 12827
|
Does Knockout of Tcirg1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Tcirg1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tcirg1 (T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, T cell differentiation, T cell homeostasis, T-helper 1 cell activation, apoptotic process, autophagosome assembly, autophagy, bone resorption, cellular response to cytokine stimulus, dentin mineralization, enamel mineralization, establishment of cell polarity, establishment of vesicle localization, gene expression, hematopoietic stem cell homeostasis, homeostasis of number of cells, immunoglobulin mediated immune response, inflammatory response, intracellular calcium ion homeostasis, intracellular pH reduction, macroautophagy, memory T cell activation, monoatomic ion transport, myeloid cell differentiation, odontogenesis, optic nerve development, ossification, osteoclast differentiation, osteoclast proliferation, pH reduction, phagosome acidification, protein catabolic process in the vacuole, proton transmembrane transport, regulation of gene expression, regulation of insulin secretion, regulation of osteoblast differentiation, regulation of proton transport, response to silver ion, retina development in camera-type eye, ruffle organization, tooth eruption, vacuolar acidification; MF: ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism; CC: apical plasma membrane, late endosome, lysosome, membrane, mitochondrion, nucleus, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane, proton-transporting V-type ATPase, V0 domain, secretory granule membrane, vacuolar proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V0 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Lysosome - Mus musculus (mouse), Neutrophil degranulation, Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, Tuberculosis - Mus musculus (mouse)
UniProt: F6ZFB8, Q9JHF5, F6XRE6, D6RFN1, A0A494B9E3
Entrez ID: 27060
|
Does Knockout of Mmp9 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Mmp9
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Mmp9 (matrix metallopeptidase 9)
Type: protein-coding
Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades collagens of type IV, V and XI, and elastin. Mice lacking the encoded protein exhibit an abnormal pattern of skeletal growth plate vascularization and ossification, reduced keratinocyte hyperproliferation at all neoplastic stages, a decreased incidence of invasive tumors, and resistance to experimental autoimmune encephalomyelitis. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: cell migration, cellular response to UV-A, cellular response to cell-matrix adhesion, collagen catabolic process, embryo implantation, endodermal cell differentiation, extracellular matrix organization, heart development, macrophage chemotaxis, modification of synaptic structure, modulating synaptic transmission, negative regulation of apoptotic process, negative regulation of cation transmembrane transport, negative regulation of epithelial cell differentiation involved in kidney development, negative regulation of fibroblast proliferation, negative regulation of intrinsic apoptotic signaling pathway, positive regulation of angiogenesis, positive regulation of apoptotic process, positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of keratinocyte migration, positive regulation of leukocyte migration, positive regulation of release of cytochrome c from mitochondria, positive regulation of synaptic plasticity, positive regulation of vascular associated smooth muscle cell proliferation, protein catabolic process, proteolysis, regulation of multicellular organismal process, regulation of postsynaptic neurotransmitter receptor diffusion trapping, response to amyloid-beta, response to oxidative stress, response to xenobiotic stimulus, skeletal system development, tissue remodeling; MF: endopeptidase activity, fibronectin binding, hydrolase activity, identical protein binding, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, protein-containing complex binding, serine-type endopeptidase activity, zinc ion binding; CC: Schaffer collateral - CA1 synapse, extracellular matrix, extracellular matrix of synaptic cleft, extracellular region, extracellular space, glutamatergic synapse, postsynaptic density, intracellular component, protein-containing complex
Pathways: Activation of Matrix Metalloproteinases, Assembly of collagen fibrils and other multimeric structures, Axon guidance, Bladder cancer - Mus musculus (mouse), Collagen degradation, Collagen formation, Degradation of the extracellular matrix, Developmental Biology, Diabetic cardiomyopathy - Mus musculus (mouse), EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, ESR-mediated signaling, Estrogen signaling pathway - Mus musculus (mouse), Extra-nuclear estrogen signaling, Extracellular matrix organization, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Innate Immune System, Leukocyte transendothelial migration - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Nervous system development, Neutrophil degranulation, Pathways in cancer - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, TNF signaling pathway - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: P41245
Entrez ID: 17395
|
Does Knockout of Gps2 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Gps2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Gps2 (G protein pathway suppressor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, negative regulation of B cell receptor signaling pathway, negative regulation of JNK cascade, negative regulation of fat cell differentiation, negative regulation of inflammatory response, negative regulation of protein K63-linked ubiquitination, negative regulation of toll-like receptor signaling pathway, negative regulation of transcription by RNA polymerase II, negative regulation of tumor necrosis factor-mediated signaling pathway, positive regulation of cholesterol efflux, positive regulation of peroxisome proliferator activated receptor signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of fat cell differentiation, regulation of lipid metabolic process, regulation of transcription by RNA polymerase II, response to mitochondrial depolarisation; MF: cyclin binding, protein binding, transcription coactivator activity, transcription coregulator activity, transcription corepressor activity; CC: cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus, transcription regulator complex, transcription repressor complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), HDACs deacetylate histones, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, NR1H2 and NR1H3-mediated signaling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Signal Transduction, Signaling by Nuclear Receptors
UniProt: Q921N8
Entrez ID: 56310
|
Does Knockout of Gpm6b in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Gpm6b
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Gpm6b (glycoprotein m6b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon development, central nervous system myelination, extracellular matrix assembly, negative regulation of protein localization to cell surface, negative regulation of serotonin uptake, ossification, positive regulation of bone mineralization, protein transport, regulation of actin cytoskeleton organization, regulation of focal adhesion assembly; CC: membrane, membrane raft, myelin sheath, plasma membrane
Pathways:
UniProt: P35803
Entrez ID: 14758
|
Does Knockout of Hinfp in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Hinfp
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Hinfp (histone H4 transcription factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA repair, DNA-templated transcription, G1/S transition of mitotic cell cycle, cell cycle G1/S phase transition, establishment of protein localization, in utero embryonic development, myoblast differentiation, negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, enzyme binding, histone binding, metal ion binding, transcription cis-regulatory region binding, zinc ion binding; CC: Cajal body, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8K1K9
Entrez ID: 102423
|
Does Knockout of Art2b in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Art2b
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Art2b (ADP-ribosyltransferase 2b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: NAD+ nucleosidase activity, NAD+ poly-ADP-ribosyltransferase activity, NAD+-protein-arginine ADP-ribosyltransferase activity, glycosyltransferase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, nucleotidyltransferase activity, pentosyltransferase activity, transferase activity; CC: external side of plasma membrane, extrinsic component of plasma membrane, membrane, plasma membrane, side of membrane
Pathways: Nicotinate and nicotinamide metabolism - Mus musculus (mouse)
UniProt: O35975
Entrez ID: 11872
|
Does Knockout of Park7 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Park7
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Park7 (Parkinson disease (autosomal recessive, early onset) 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, adult locomotory behavior, androgen receptor signaling pathway, autophagy, cellular detoxification of aldehyde, cellular detoxification of methylglyoxal, cellular response to glyoxal, cellular response to hydrogen peroxide, cellular response to oxidative stress, cellular response to oxygen-containing compound, cellular response to reactive oxygen species, cellular response to stress, detection of oxidative stress, detoxification of copper ion, detoxification of hydrogen peroxide, detoxification of mercury ion, dopamine uptake involved in synaptic transmission, glucose homeostasis, glycolate biosynthetic process, glyoxal catabolic process, glyoxal metabolic process, guanine deglycation, guanine deglycation, glyoxal removal, guanine deglycation, methylglyoxal removal, hydrogen peroxide metabolic process, inflammatory response, insulin secretion, lactate biosynthetic process, membrane depolarization, membrane hyperpolarization, methylglyoxal catabolic process to lactate, methylglyoxal metabolic process, mitochondrion organization, negative regulation of TRAIL-activated apoptotic signaling pathway, negative regulation of death-inducing signaling complex assembly, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of gene expression, negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway, negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide, negative regulation of neuron apoptotic process, negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of protein K48-linked deubiquitination, negative regulation of protein catabolic process, negative regulation of protein export from nucleus, negative regulation of protein sumoylation, negative regulation of protein ubiquitination, negative regulation of reactive oxygen species biosynthetic process, negative regulation of smooth muscle cell migration, negative regulation of vascular associated smooth muscle cell proliferation, positive regulation of L-dopa biosynthetic process, positive regulation of NAD(P)H oxidase activity, positive regulation of acute inflammatory response to antigenic stimulus, positive regulation of dopamine biosynthetic process, positive regulation of fertilization, positive regulation of gene expression, positive regulation of interleukin-8 production, positive regulation of mitochondrial electron transport, NADH to ubiquinone, positive regulation of oxidative phosphorylation uncoupler activity, positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein localization to nucleus, positive regulation of protein-containing complex assembly, positive regulation of reactive oxygen species biosynthetic process, positive regulation of reactive oxygen species metabolic process, positive regulation of transcription by RNA polymerase II, protein repair, protein stabilization, proteolysis, regulation of androgen receptor signaling pathway, regulation of inflammatory response, regulation of mitochondrial membrane potential, regulation of neuron apoptotic process, regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, regulation of synaptic vesicle endocytosis, removal of superoxide radicals, response to hydrogen peroxide, response to oxidative stress, single fertilization, synaptic transmission, dopaminergic; MF: DNA-binding transcription factor binding, L-dopa decarboxylase activator activity, RNA binding, copper ion binding, cupric ion binding, cuprous ion binding, cytokine binding, enzyme activator activity, enzyme binding, glyoxalase (glycolic acid-forming) activity, hydrolase activity, identical protein binding, kinase binding, mRNA binding, mercury ion binding, nuclear androgen receptor binding, oxidoreductase activity, acting on peroxide as acceptor, oxygen sensor activity, peptidase activity, peptidase inhibitor activity, peroxiredoxin activity, protein binding, protein deglycase activity, protein homodimerization activity, scaffold protein binding, signaling receptor activator activity, signaling receptor binding, small protein activating enzyme binding, superoxide dismutase copper chaperone activity, transcription coactivator activity, tyrosine 3-monooxygenase activator activity, ubiquitin-like protein conjugating enzyme binding, ubiquitin-protein transferase inhibitor activity, ubiquitin-specific protease binding; CC: PML body, axon, cell body, chromatin, cytoplasm, cytosol, endoplasmic reticulum, membrane, membrane raft, mitochondrial intermembrane space, mitochondrial matrix, mitochondrion, neuron projection, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, sperm head, synaptic vesicle
Pathways: Aggrephagy, Autophagy, Macroautophagy, Metabolism of proteins, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription cofactors, Selective autophagy
UniProt: Q99LX0
Entrez ID: 57320
|
Does Knockout of Acaa1b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Acaa1b
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Acaa1b (acetyl-Coenzyme A acyltransferase 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alpha-linolenic acid metabolic process, bile acid metabolic process, fatty acid beta-oxidation, fatty acid beta-oxidation using acyl-CoA oxidase, fatty acid derivative biosynthetic process, fatty acid metabolic process, lipid metabolic process, long-chain fatty acid biosynthetic process, phenylacetate catabolic process, unsaturated fatty acid biosynthetic process, very long-chain fatty acid metabolic process; MF: acetate CoA-transferase activity, acetyl-CoA C-acetyltransferase activity, acetyl-CoA C-acyltransferase activity, acetyl-CoA C-myristoyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, transferase activity; CC: mitochondrion, peroxisomal matrix, peroxisome
Pathways: Beta-oxidation of very long chain fatty acids, Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid degradation - Mus musculus (mouse), Fatty acid metabolism, Immune System, Innate Immune System, Metabolism, Metabolism of lipids, Neutrophil degranulation, PPAR signaling pathway - Mus musculus (mouse), Peroxisomal lipid metabolism, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Protein localization, Valine, leucine and isoleucine degradation - Mus musculus (mouse), alpha-Linolenic acid metabolism - Mus musculus (mouse), alpha-linolenic (omega3) and linoleic (omega6) acid metabolism, alpha-linolenic acid (ALA) metabolism
UniProt: Q8VCH0
Entrez ID: 235674
|
Does Knockout of Syt8 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Syt8
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Syt8 (synaptotagmin VIII)
Type: protein-coding
Summary: Enables calcium-dependent protein binding activity. Involved in acrosome reaction. Located in cytoplasm and vesicle. Is expressed in bladder. Orthologous to human SYT8 (synaptotagmin 8). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: acrosome reaction, calcium-dependent activation of synaptic vesicle fusion, regulation of calcium ion-dependent exocytosis, regulation of synaptic vesicle exocytosis, vesicle-mediated transport; MF: SNARE binding, calcium ion sensor activity, calcium-dependent phospholipid binding, calcium-dependent protein binding, clathrin binding; CC: acrosomal vesicle, axon, cytoplasm, cytoplasmic vesicle, dense core granule, exocytic vesicle, membrane, plasma membrane, synaptic vesicle membrane, vesicle
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q9R0N6
Entrez ID: 55925
|
Does Knockout of Slc39a10 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Slc39a10
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slc39a10 (solute carrier family 39 (zinc transporter), member 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bicarbonate transport, epithelial to mesenchymal transition, intracellular monoatomic cation homeostasis, intracellular zinc ion homeostasis, metal ion transport, monoatomic ion transport, negative regulation of B cell apoptotic process, positive regulation of B cell proliferation, positive regulation of B cell receptor signaling pathway, transmembrane transport, zinc ion import across plasma membrane, zinc ion transmembrane transport, zinc ion transport; MF: metal ion transmembrane transporter activity, monoatomic cation:bicarbonate symporter activity, protein binding, protein tyrosine phosphatase activator activity, zinc ion transmembrane transporter activity; CC: apical plasma membrane, membrane, plasma membrane
Pathways: Alzheimer disease - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse)
UniProt: Q6P5F6
Entrez ID: 227059
|
Does Knockout of Tars2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Tars2
|
cell cycle progression
|
breast epithelium
|
Gene: Tars2 (threonyl-tRNA synthetase 2, mitochondrial (putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aminoacyl-tRNA metabolism involved in translational fidelity, tRNA aminoacylation, tRNA aminoacylation for protein translation, threonyl-tRNA aminoacylation, translation; MF: ATP binding, aminoacyl-tRNA deacylase activity, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, protein homodimerization activity, threonine-tRNA ligase activity; CC: cytoplasm, mitochondrial matrix, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q3UQ84
Entrez ID: 71807
|
Does Knockout of Ribc2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Ribc2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ribc2 (RIB43A domain with coiled-coils 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, flagellated sperm motility; CC: axonemal A tubule inner sheath, axonemal microtubule, cell projection, cilium, cytoplasm, cytoskeleton, motile cilium, sperm flagellum
Pathways:
UniProt: Q9D4Q1
Entrez ID: 67747
|
Does Knockout of BC024139 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
BC024139
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: BC024139 (cDNA sequence BC024139)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, cytoskeleton
Pathways:
UniProt: E9PXU3, Q8BVJ3, E9Q3A6
Entrez ID: 271278
|
Does Knockout of Ggcx in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Ggcx
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ggcx (gamma-glutamyl carboxylase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to insulin stimulus, glucose homeostasis, negative regulation of bone development, negative regulation of neurotransmitter secretion, negative regulation of testosterone biosynthetic process, protein maturation, type B pancreatic cell proliferation, vitamin K metabolic process; MF: gamma-glutamyl carboxylase activity, lyase activity, vitamin binding; CC: endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum membrane, membrane
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Gamma-carboxylation of protein precursors, Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, Metabolism of proteins, Post-translational protein modification, Ubiquinone and other terpenoid-quinone biosynthesis - Mus musculus (mouse)
UniProt: Q9QYC7
Entrez ID: 56316
|
Does Knockout of Ube2dnl2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Ube2dnl2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ube2dnl2 (ubiquitin-conjugating enzyme E2D N-terminal like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein polyubiquitination, ubiquitin-dependent protein catabolic process; MF: ATP binding, nucleotide binding, transferase activity, ubiquitin conjugating enzyme activity
Pathways: Protein processing in endoplasmic reticulum - Mus musculus (mouse), Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: A2AFH2
Entrez ID: 75097
|
Does Knockout of Ces2h in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Ces2h
|
response to bacteria
|
renal medulla cell line
|
Gene: Ces2h (carboxylesterase 2H)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carboxylesterase activity, carboxylic ester hydrolase activity, hydrolase activity
Pathways: Drug metabolism - other enzymes - Mus musculus (mouse)
UniProt: F6Z9B9
Entrez ID: 436059
|
Does Knockout of Ifne in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Ifne
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ifne (interferon epsilon)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation involved in immune response, T cell activation involved in immune response, adaptive immune response, defense response, defense response to bacterium, defense response to virus, humoral immune response, natural killer cell activation involved in immune response, response to exogenous dsRNA, type I interferon-mediated signaling pathway; MF: cytokine activity, cytokine receptor binding, type I interferon receptor binding; CC: extracellular region, extracellular space
Pathways: Cytokine-cytokine receptor interaction - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse)
UniProt: Q80ZF2
Entrez ID: 230405
|
Does Knockout of Tax1bp3 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Tax1bp3
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Tax1bp3 (Tax1 (human T cell leukemia virus type I) binding protein 3)
Type: protein-coding
Summary: Enables beta-catenin binding activity. Involved in negative regulation of Wnt signaling pathway. Acts upstream of or within negative regulation of cell population proliferation. Located in cytoplasm and nucleus. Is expressed in retina. Orthologous to human TAX1BP3 (Tax1 binding protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Rho protein signal transduction, Wnt signaling pathway, negative regulation of Wnt signaling pathway, negative regulation of cell population proliferation, negative regulation of protein localization to cell surface, regulation of Cdc42 protein signal transduction; MF: beta-catenin binding, protein binding; CC: actin cytoskeleton, cytoplasm, fibrillar center, membrane, nucleus, plasma membrane
Pathways: RHO GTPase Effectors, RHO GTPases Activate Rhotekin and Rhophilins, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9DBG9
Entrez ID: 76281
|
Does Knockout of Asxl2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Asxl2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Asxl2 (ASXL transcriptional regulator 2)
Type: protein-coding
Summary: This gene encodes a homolog of the Drosophila Asx gene, which interacts with genes involved in axial patterning. Mice with mutations in this gene display abnormal patterning of the axial skeleton, suggesting a similar function in mice as in Drosophila. This gene may also be involved in bone mineral density, specifically osteoclastogenesis. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: adult heart development, animal organ morphogenesis, embryonic skeletal system morphogenesis, heart development, heart morphogenesis, negative regulation of transcription by RNA polymerase II, positive regulation of bone mineralization involved in bone maturation, positive regulation of fat cell differentiation, positive regulation of lipid storage, positive regulation of macrophage differentiation, positive regulation of osteoclast differentiation, positive regulation of peroxisome proliferator activated receptor signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription; MF: DNA binding, chromatin binding, metal ion binding, peroxisome proliferator activated receptor binding, protein binding, zinc ion binding; CC: PR-DUB complex, nucleoplasm, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, UCH proteinases
UniProt: Q8BZ32
Entrez ID: 75302
|
Does Knockout of Cog2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Cog2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cog2 (component of oligomeric golgi complex 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, glycosylation, intra-Golgi vesicle-mediated transport, protein transport, retrograde transport, vesicle recycling within Golgi; MF: protein-containing complex binding; CC: Golgi apparatus, Golgi membrane, Golgi stack, Golgi transport complex, membrane
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Retrograde transport at the Trans-Golgi-Network, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q921L5
Entrez ID: 76332
|
Does Knockout of Chga in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Chga
|
phagocytosis
|
macrophage
|
Gene: Chga (chromogranin A)
Type: protein-coding
Summary: This gene encodes a member of the granin family of acidic secretory glycoproteins that are expressed in endocrine cells and neurons. The encoded preproprotein undergoes proteolytic processing to generate multiple functions peptides including pancreastatin, catestatin and serpinin. The encoded protein plays important roles in the neuroendocrine system including regulated secretion of peptide hormones and neurotransmitters. Mice lacking the encoded protein exhibit elevated blood pressure which can be rescued by transgenic expression of the human ortholog. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, mast cell activation, mast cell chemotaxis, mast cell degranulation, negative regulation of catecholamine secretion, negative regulation of insulin secretion, positive regulation of cAMP/PKA signal transduction, positive regulation of cardiac muscle contraction, positive regulation of dense core granule biogenesis, positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of relaxation of cardiac muscle, positive regulation of vasoconstriction, protein localization to secretory granule, regulation of cytosolic calcium ion concentration, regulation of the force of heart contraction; CC: chromaffin granule, cytoplasmic vesicle, extracellular region, extracellular space, neuronal dense core vesicle, perinuclear region of cytoplasm, secretory granule, transport vesicle
Pathways: Antimicrobial peptides, Immune System, Innate Immune System
UniProt: P26339
Entrez ID: 12652
|
Does Knockout of Umod in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Umod
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Umod (uromodulin)
Type: protein-coding
Summary: This gene encodes a glycoprotein that is the most abundant protein in mammalian urine under physiological conditions. It is synthesized in the kidney as a glycosyl-phosphatidylinositol anchored protein and released into urine as a soluble form by proteolytic cleavage. It is thought to regulate water and salt balance in the thick ascending limb of Henle and to protect against urinary tract infection and calcium oxalate crystal formation. In mouse deficiency of this gene is associated with increased susceptibility to bacterial infections and formation of calcium crystals in kidneys. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: ERAD pathway, RNA splicing, antibacterial innate immune response, apoptotic process, apoptotic signaling pathway, autophagy, calcium ion homeostasis, cellular response to stress, cellular response to unfolded protein, chemical homeostasis, chloride ion homeostasis, citric acid secretion, collecting duct development, connective tissue replacement, defense response to Gram-negative bacterium, endoplasmic reticulum organization, gene expression, glomerular filtration, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, immune system process, inflammatory response, innate immune response, intracellular calcium ion homeostasis, intracellular chloride ion homeostasis, intracellular phosphate ion homeostasis, intracellular sodium ion homeostasis, juxtaglomerular apparatus development, kidney development, leukocyte cell-cell adhesion, lipid metabolic process, loop of Henle development, metanephric ascending thin limb development, metanephric distal convoluted tubule development, metanephric thick ascending limb development, micturition, monoatomic ion homeostasis, multicellular organismal response to stress, multicellular organismal-level homeostasis, multicellular organismal-level water homeostasis, neutrophil migration, organ or tissue specific immune response, phosphate ion homeostasis, potassium ion homeostasis, protein folding, protein localization to vacuole, protein transport into plasma membrane raft, regulation of blood pressure, regulation of protein transport, regulation of urine volume, renal sodium ion absorption, renal urate salt excretion, renal water homeostasis, response to endoplasmic reticulum stress, response to lipopolysaccharide, response to unfolded protein, response to water deprivation, response to xenobiotic stimulus, sodium ion homeostasis, tumor necrosis factor-mediated signaling pathway, urate transport, urea transmembrane transport; MF: IgG binding, calcium ion binding, protein binding; CC: apical part of cell, apical plasma membrane, basolateral plasma membrane, cell projection, cell surface, ciliary membrane, cilium, endoplasmic reticulum, extracellular region, extracellular space, membrane, plasma membrane, side of membrane, spindle pole
Pathways: Asparagine N-linked glycosylation, Metabolism of proteins, Post-translational protein modification
UniProt: Q91X17
Entrez ID: 22242
|
Does Knockout of Cep170b in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Cep170b
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cep170b (centrosomal protein 170B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, cytoplasm, cytoskeleton, microtubule
Pathways:
UniProt: Q80U49
Entrez ID: 217882
|
Does Knockout of Apba3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Apba3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Apba3 (amyloid beta precursor protein binding family A member 3)
Type: protein-coding
Summary: Predicted to enable amyloid-beta binding activity; enzyme binding activity; and enzyme inhibitor activity. Acts upstream of or within chemical synaptic transmission; in utero embryonic development; and regulation of gene expression. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm; dendritic spine; and plasma membrane. Orthologous to human APBA3 (amyloid beta precursor protein binding family A member 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chemical synaptic transmission, in utero embryonic development, protein transport, regulation of gene expression; MF: amyloid-beta binding, enzyme binding, enzyme inhibitor activity; CC: cytoplasm, dendritic spine, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: O88888
Entrez ID: 57267
|
Does Knockout of Hepacam2 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Hepacam2
|
cell proliferation
|
Regulatory T cell
|
Gene: Hepacam2 (HEPACAM family member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, centrosome cycle; CC: Golgi apparatus, Golgi membrane, centrosome, cytoplasm, cytoskeleton, membrane, midbody, mitotic spindle, nucleoplasm, spindle
Pathways:
UniProt: Q4VAH7
Entrez ID: 101202
|
Does Knockout of Vmn2r105 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Vmn2r105
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Vmn2r105 (vomeronasal 2, receptor 105)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A3B2WCN5, A0A3B2W8C2, A0A3B2WD24, A0A3B2WCT8, A0A3B2WD54, E9Q3A5, A0A3B2W7M0, A0A3B2W879
Entrez ID: 627743
|
Does Knockout of Vmn2r1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Vmn2r1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Vmn2r1 (vomeronasal 2, receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, neuron differentiation, response to pheromone, signal transduction; MF: G protein-coupled olfactory receptor activity, G protein-coupled receptor activity, olfactory receptor activity; CC: cell cortex, dendrite, membrane, plasma membrane
Pathways:
UniProt: O70410
Entrez ID: 56544
|
Does Knockout of Icos in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Icos
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Icos (inducible T cell co-stimulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell costimulation, T cell tolerance induction, T follicular helper cell differentiation, cell-cell adhesion; MF: protein binding, signaling receptor activity; CC: external side of plasma membrane, membrane, plasma membrane
Pathways: Adaptive Immune System, Cell adhesion molecules - Mus musculus (mouse), Co-stimulation by ICOS, Immune System, Intestinal immune network for IgA production - Mus musculus (mouse), Intracellular signaling by second messengers, Negative regulation of the PI3K/AKT network, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Primary immunodeficiency - Mus musculus (mouse), Regulation of T cell activation by CD28 family, Signal Transduction, T cell receptor signaling pathway - Mus musculus (mouse)
UniProt: Q9WVS0
Entrez ID: 54167
|
Does Knockout of Myo16 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Myo16
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Myo16 (myosin XVI)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cerebellum development, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of cell population proliferation, neuron projection morphogenesis, phosphatidylinositol 3-kinase/protein kinase B signal transduction; MF: ATP binding, actin binding, actin filament binding, cytoskeletal motor activity, nucleotide binding, protein binding, protein phosphatase binding, protein-containing complex binding; CC: cytoplasm, myosin complex, nucleoplasm, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q5DU14
Entrez ID: 244281
|
Does Knockout of Mrpl14 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Mrpl14
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Mrpl14 (mitochondrial ribosomal protein L14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9D1I6
Entrez ID: 68463
|
Does Knockout of Ruvbl2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 163
|
Knockout
|
Ruvbl2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ruvbl2 (RuvB-like AAA ATPase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, box C/D snoRNP assembly, cellular response to UV, cellular response to estradiol stimulus, chromatin organization, chromatin remodeling, establishment of protein localization to chromatin, negative regulation of DNA-templated transcription, negative regulation of canonical Wnt signaling pathway, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, positive regulation of telomere maintenance in response to DNA damage, positive regulation of transcription by RNA polymerase II, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of chromosome organization, regulation of double-strand break repair, regulation of embryonic development, regulation of transcription by RNA polymerase II, telomere maintenance; MF: ADP binding, ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATPase binding, DNA helicase activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, TBP-class protein binding, TFIID-class transcription factor complex binding, beta-catenin binding, chromatin DNA binding, helicase activity, hydrolase activity, identical protein binding, nucleotide binding, promoter-enhancer loop anchoring activity, protein binding, protein homodimerization activity, transcription corepressor activity; CC: Ino80 complex, MLL1 complex, NuA4 histone acetyltransferase complex, R2TP complex, RPAP3/R2TP/prefoldin-like complex, Swr1 complex, centrosome, ciliary basal body, cytoplasm, cytosol, dynein axonemal particle, euchromatin, membrane, nuclear matrix, nucleoplasm, nucleosome, nucleus, protein folding chaperone complex, ribonucleoprotein complex
Pathways:
UniProt: Q9WTM5
Entrez ID: 20174
|
Does Knockout of Slc27a5 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,180
|
Knockout
|
Slc27a5
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Slc27a5 (solute carrier family 27 (fatty acid transporter), member 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bile acid biosynthetic process, bile acid metabolic process, establishment of localization in cell, fatty acid metabolic process, fatty acid transport, ketone body biosynthetic process, lipid metabolic process, lipid transport, long-chain fatty acid import across plasma membrane, long-chain fatty acid import into cell, long-chain fatty acid metabolic process, triglyceride mobilization, very long-chain fatty acid metabolic process; MF: ATP binding, cholate-CoA ligase activity, fatty acid transmembrane transporter activity, ligase activity, long-chain fatty acid transmembrane transporter activity, long-chain fatty acid-CoA ligase activity, nucleotide binding, protein-containing complex binding, very long-chain fatty acid-CoA ligase activity; CC: basal plasma membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane, protein-containing complex
Pathways: Bile acid and bile salt metabolism, Bile secretion - Mus musculus (mouse), Insulin resistance - Mus musculus (mouse), Metabolism, Metabolism of lipids, Metabolism of steroids, PPAR signaling pathway - Mus musculus (mouse), Primary bile acid biosynthesis - Mus musculus (mouse), Recycling of bile acids and salts, Synthesis of bile acids and bile salts, Synthesis of bile acids and bile salts via 24-hydroxycholesterol, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol, fatty acid β-oxidation I, fatty acid β-oxidation II (core pathway)
UniProt: Q4LDG0
Entrez ID: 26459
|
Does Knockout of Ghrh in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Ghrh
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ghrh (growth hormone releasing hormone)
Type: protein-coding
Summary: This gene encodes a hormone that has stimulatory effects on pituitary growth hormone synthesis and release, and somatotrope expansion. The encoded preproprotein undergoes proteolytic processing to generate the mature peptide that is secreted by hypothalamus. Mice lacking the encoded protein are deficient in the growth hormone, live longer and exhibit growth retardation, enhanced insulin sensitivity and increased xenobiotic metabolism. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: adenohypophysis development, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, growth hormone secretion, multicellular organism growth, negative regulation of cardiac muscle cell apoptotic process, positive regulation of DNA-templated transcription, positive regulation of cAMP/PKA signal transduction, positive regulation of cell population proliferation, positive regulation of circadian sleep/wake cycle, non-REM sleep, positive regulation of cytosolic calcium ion concentration, positive regulation of growth hormone secretion, positive regulation of hormone secretion, positive regulation of multicellular organism growth, regulation of protein localization, response to food; MF: growth hormone-releasing hormone activity, growth hormone-releasing hormone receptor binding, hormone activity, neuropeptide hormone activity, peptide hormone receptor binding, protein binding, signaling receptor binding; CC: axon terminus, extracellular region, extracellular space, perikaryon, terminal bouton
Pathways: Class B/2 (Secretin family receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, Glucagon-type ligand receptors, Growth hormone synthesis, secretion and action - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: P16043
Entrez ID: 14601
|
Does Knockout of Prss3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Prss3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Prss3 (serine protease 3)
Type: protein-coding
Summary: Enables serine-type peptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to several human genes including PRSS1 (serine protease 1) and PRSS2 (serine protease 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: proteolysis; MF: calcium ion binding, hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular matrix, extracellular region, extracellular space
Pathways: Activation of Matrix Metalloproteinases, Alpha-defensins, Antimicrobial peptides, Defensins, Degradation of the extracellular matrix, Extracellular matrix organization, Immune System, Influenza A - Mus musculus (mouse), Innate Immune System, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neutrophil degranulation, Pancreatic secretion - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse)
UniProt: Q792Z0
Entrez ID: 22073
|
Does Knockout of Slc5a10 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Slc5a10
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Slc5a10 (solute carrier family 5 (sodium/glucose cotransporter), member 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate transmembrane transport, fructose transmembrane transport, hexose transmembrane transport, mannose transmembrane transport, monoatomic ion transport, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: D-glucose:sodium symporter activity, carbohydrate:monoatomic cation symporter activity, fructose:sodium symporter activity, hexose transmembrane transporter activity, mannose:sodium symporter activity, solute:sodium symporter activity, transmembrane transporter activity; CC: apical plasma membrane, membrane, plasma membrane
Pathways: Cellular hexose transport, SLC-mediated transmembrane transport, Transport of small molecules
UniProt: Q5SWY8
Entrez ID: 109342
|
Does Knockout of Adrm1 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Adrm1
|
phagocytosis
|
macrophage
|
Gene: Adrm1 (adhesion regulating molecule 1 26S proteasome ubiquitin receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Sertoli cell development, adipose tissue development, follicle-stimulating hormone signaling pathway, oogenesis, ovarian follicle development, positive regulation of growth hormone receptor signaling pathway, proteasome assembly, regulation of T cell differentiation in thymus, seminiferous tubule development, spermatid development, thymus development, transcription elongation by RNA polymerase II; MF: endopeptidase activator activity, molecular function inhibitor activity, protease binding, proteasome binding, protein binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus, plasma membrane, proteasome complex, proteasome regulatory particle, lid subcomplex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9JKV1
Entrez ID: 56436
|
Does Knockout of Txnrd1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Txnrd1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Txnrd1 (thioredoxin reductase 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms. [provided by RefSeq, May 2017].
Gene Ontology: BP: benzene-containing compound metabolic process, cell population proliferation, cell redox homeostasis, cellular oxidant detoxification, gastrulation, hydrogen peroxide catabolic process, mesoderm formation, positive regulation of apoptotic process, response to oxidative stress, selenocysteine metabolic process; MF: FAD binding, NAD(P)H oxidase H2O2-forming activity, NADPH peroxidase activity, flavin adenine dinucleotide binding, identical protein binding, mercury ion binding, oxidoreductase activity, oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor, selenate reductase activity, thioredoxin-disulfide reductase (NADPH) activity; CC: cytoplasm, cytosol, fibrillar center, mitochondrion, neuronal cell body, nucleoplasm, nucleus
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Detoxification of Reactive Oxygen Species, Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of amino acids and derivatives, Metabolism of ingested MeSeO2H into MeSeH, Metabolism of nucleotides, Pathways in cancer - Mus musculus (mouse), RNA Polymerase II Transcription, Selenoamino acid metabolism, Selenocompound metabolism - Mus musculus (mouse), TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, thioredoxin pathway
UniProt: Q9JMH6
Entrez ID: 50493
|
Does Knockout of Retnlb in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Retnlb
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Retnlb (resistin like beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: response to bacterium, signal transduction; CC: extracellular region, extracellular space
Pathways:
UniProt: Q99P86
Entrez ID: 57263
|
Does Knockout of Gps2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Gps2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gps2 (G protein pathway suppressor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, negative regulation of B cell receptor signaling pathway, negative regulation of JNK cascade, negative regulation of fat cell differentiation, negative regulation of inflammatory response, negative regulation of protein K63-linked ubiquitination, negative regulation of toll-like receptor signaling pathway, negative regulation of transcription by RNA polymerase II, negative regulation of tumor necrosis factor-mediated signaling pathway, positive regulation of cholesterol efflux, positive regulation of peroxisome proliferator activated receptor signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of fat cell differentiation, regulation of lipid metabolic process, regulation of transcription by RNA polymerase II, response to mitochondrial depolarisation; MF: cyclin binding, protein binding, transcription coactivator activity, transcription coregulator activity, transcription corepressor activity; CC: cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus, transcription regulator complex, transcription repressor complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), HDACs deacetylate histones, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, NR1H2 and NR1H3-mediated signaling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Signal Transduction, Signaling by Nuclear Receptors
UniProt: Q921N8
Entrez ID: 56310
|
Does Knockout of Ndst3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Ndst3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ndst3 (N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3)
Type: protein-coding
Summary: Enables N-acetylglucosamine deacetylase activity and heparan sulfate N-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including exocrine system; future brain; genitourinary system; nervous system; and retina. Orthologous to human NDST3 (N-deacetylase and N-sulfotransferase 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: heparan sulfate proteoglycan biosynthetic process, heparin proteoglycan biosynthetic process; MF: N-acetylglucosamine deacetylase activity, catalytic activity, deacetylase activity, heparan sulfate N-deacetylase activity, heparan sulfate N-sulfotransferase activity, hydrolase activity, sulfotransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Mus musculus (mouse), Glycosaminoglycan metabolism, HS-GAG biosynthesis, Heparan sulfate/heparin (HS-GAG) metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, heparan sulfate biosynthesis, heparan sulfate biosynthesis (late stages)
UniProt: Q9EQH7
Entrez ID: 83398
|
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