prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Akirin2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Akirin2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Akirin2 (akirin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, cerebral cortex development, defense response to bacterium, embryo development ending in birth or egg hatching, immune system process, innate immune response, negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, nuclear protein quality control by the ubiquitin-proteasome system, positive regulation of B cell activation, positive regulation of adaptive immune response, positive regulation of cell population proliferation, positive regulation of innate immune response, positive regulation of interleukin-6 production, positive regulation of transcription by RNA polymerase II, proteasomal protein catabolic process, proteasome localization, protein import into nucleus, protein transport, regulation of muscle cell differentiation, response to lipopolysaccharide; MF: enzyme binding, identical protein binding, protein binding, protein-macromolecule adaptor activity, transcription coregulator activity; CC: chromatin, cytoplasm, membrane, nucleoplasm, nucleus, transcription repressor complex
Pathways:
UniProt: B1AXD8
Entrez ID: 433693
|
Does Knockout of Fmr1nb in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Fmr1nb
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Fmr1nb (Fmr1 neighbor)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q80ZA7
Entrez ID: 207854
|
Does Knockout of Canx in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Canx
|
cell cycle progression
|
breast epithelium
|
Gene: Canx (calnexin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, clathrin-dependent endocytosis, protein folding, synaptic vesicle endocytosis; MF: apolipoprotein binding, calcium ion binding, carbohydrate binding, ionotropic glutamate receptor binding, metal ion binding, protein binding, unfolded protein binding; CC: axon, dendrite cytoplasm, dendritic spine, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum quality control compartment, glutamatergic synapse, lumenal side of endoplasmic reticulum membrane, melanosome membrane, membrane, mitochondria-associated endoplasmic reticulum membrane contact site, mitochondrial membrane, mitochondrion, myelin sheath, neuronal cell body, nuclear envelope, nuclear membrane, postsynaptic membrane, presynapse, presynaptic active zone membrane, protein-containing complex, ribosome, smooth endoplasmic reticulum
Pathways: Adaptive Immune System, Adherens junctions interactions, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Mus musculus (mouse), Asparagine N-linked glycosylation, Calnexin/calreticulin cycle, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Interleukin-12 family signaling, Interleukin-27 signaling, Interleukin-35 Signalling, MHC class II antigen presentation, Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Phagosome - Mus musculus (mouse), Post-translational protein modification, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Signaling by Interleukins, Thyroid hormone synthesis - Mus musculus (mouse)
UniProt: P35564
Entrez ID: 12330
|
Does Knockout of Unc50 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Unc50
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Unc50 (unc-50 homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein localization to cell surface; MF: RNA binding; CC: Golgi apparatus, Golgi membrane, membrane, nuclear inner membrane, nucleus
Pathways:
UniProt: Q9CQ61
Entrez ID: 67387
|
Does Knockout of H2-DMb1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
H2-DMb1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: H2-DMb1 (histocompatibility 2, class II, locus Mb1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MHC class II protein complex assembly, adaptive immune response, antigen processing and presentation, antigen processing and presentation of exogenous peptide antigen via MHC class II, antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, immune response, immune system process, peptide antigen assembly with MHC class II protein complex, positive regulation of T cell activation, positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell, positive regulation of T cell proliferation, positive regulation of immune response, protein folding; MF: MHC class II protein complex binding, peptide antigen binding; CC: MHC class II protein complex, endosome, late endosome membrane, lysosomal membrane, lysosome, membrane
Pathways: Allograft rejection - Mus musculus (mouse), Antigen processing and presentation - Mus musculus (mouse), Asthma - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Graft-versus-host disease - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Inflammatory bowel disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Intestinal immune network for IgA production - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Rheumatoid arthritis - Mus musculus (mouse), Staphylococcus aureus infection - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse)
UniProt: Q31094
Entrez ID: 14999
|
Does Knockout of Cdh23 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,175
|
Knockout
|
Cdh23
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Cdh23 (cadherin related 23 (otocadherin))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: auditory receptor cell stereocilium organization, calcium ion transport, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell migration, cell-cell adhesion via plasma-membrane adhesion molecules, cochlea development, equilibrioception, homophilic cell adhesion via plasma membrane adhesion molecules, inner ear auditory receptor cell differentiation, inner ear development, inner ear morphogenesis, inner ear receptor cell stereocilium organization, locomotory behavior, neuron projection development, photoreceptor cell maintenance, regulation of cytosolic calcium ion concentration, sensory perception of light stimulus, sensory perception of sound; MF: beta-catenin binding, cadherin binding, calcium ion binding, metal ion binding, protein binding; CC: apical part of cell, catenin complex, centrosome, cochlear hair cell ribbon synapse, kinocilium, membrane, photoreceptor inner segment, photoreceptor ribbon synapse, plasma membrane, stereocilium, stereocilium tip, synapse
Pathways:
UniProt: Q99PF4
Entrez ID: 22295
|
Does Knockout of Serpinb6d in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Serpinb6d
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Serpinb6d (serine (or cysteine) peptidase inhibitor, clade B, member 6d)
Type: protein-coding
Summary: This gene is a member of the large Serpin gene family. Many members of this family act as protease inhibitors, and have a conserved structure including a reactive center loop (RCL) that can act as a bait for protease targets. Unlike some members of this large gene family, the protein encoded by this gene is an intracellular protein, and lacks an N-terminal signal peptide sequence. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 13. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: cellular response to osmotic stress, sensory perception of sound; MF: peptidase inhibitor activity, protease binding, serine-type endopeptidase inhibitor activity; CC: cytoplasm, extracellular space, serine protease inhibitor complex
Pathways:
UniProt: Q3UWK8
Entrez ID: 238568
|
Does Knockout of Rnf113a1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Rnf113a1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rnf113a1 (ring finger protein 113A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA splicing, via spliceosome, negative regulation of chemokine-mediated signaling pathway, protein ubiquitination, snoRNA splicing; MF: metal ion binding, ubiquitin protein ligase activity, zinc ion binding; CC: U2-type precatalytic spliceosome, U2-type spliceosomal complex, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8R3P8
Entrez ID: 69942
|
Does Knockout of Tbc1d10c in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 2,188
|
Knockout
|
Tbc1d10c
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: Tbc1d10c (TBC1 domain family, member 10c)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of B cell activation, negative regulation of ERK1 and ERK2 cascade, negative regulation of calcineurin-NFAT signaling cascade, retrograde transport, endosome to Golgi; MF: GTPase activator activity; CC: cytosol, filopodium membrane, plasma membrane
Pathways: Immune System, Innate Immune System, Membrane Trafficking, Neutrophil degranulation, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: Q8C9V1
Entrez ID: 108995
|
Does Knockout of Dpf1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Dpf1
|
phagocytosis
|
macrophage
|
Gene: Dpf1 (double PHD fingers 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, nervous system development, positive regulation of cell differentiation, positive regulation of double-strand break repair, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II; MF: metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: chromatin, cytoplasm, nBAF complex, nucleoplasm, nucleus
Pathways: Hepatocellular carcinoma - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse)
UniProt: Q9QX66
Entrez ID: 29861
|
Does Knockout of Dhx40 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Dhx40
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Dhx40 (DEAH-box helicase 40)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: 3'-5' RNA helicase activity, ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding
Pathways:
UniProt: Q6PE54
Entrez ID: 67487
|
Does Knockout of Nhlrc1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Nhlrc1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Nhlrc1 (NHL repeat containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, glycogen biosynthetic process, glycogen metabolic process, positive regulation of protein ubiquitination, proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination, protein ubiquitination, regulation of gene expression, regulation of protein localization to plasma membrane, regulation of protein ubiquitination, response to endoplasmic reticulum stress, ubiquitin-dependent protein catabolic process; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytosol, endoplasmic reticulum, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q8BR37
Entrez ID: 105193
|
Does Knockout of Pou3f3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Pou3f3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pou3f3 (POU domain, class 3, transcription factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, cerebral cortex radially oriented cell migration, chemical homeostasis, forebrain ventricular zone progenitor cell division, kidney development, metanephric DCT cell differentiation, metanephric ascending thin limb development, metanephric loop of Henle development, metanephric macula densa development, metanephric thick ascending limb development, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of transcription by RNA polymerase II, nervous system development, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, urea transmembrane transport; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, HMG box domain binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, protein homodimerization activity, sequence-specific DNA binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: P31361
Entrez ID: 18993
|
Does Knockout of St8sia4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
St8sia4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: St8sia4 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: N-glycan processing, ganglioside biosynthetic process, oligosaccharide metabolic process, protein glycosylation, sialylation; MF: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity, glycosyltransferase activity, sialyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, extracellular region, membrane
Pathways: Asparagine N-linked glycosylation, Axon guidance, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Developmental Biology, Metabolism of proteins, NCAM signaling for neurite out-growth, NCAM1 interactions, Nervous system development, Post-translational protein modification, Sialic acid metabolism, Synthesis of substrates in N-glycan biosythesis
UniProt: Q64692
Entrez ID: 20452
|
Does Knockout of Psd in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Psd
|
response to bacteria
|
macrophage
|
Gene: Psd (pleckstrin and Sec7 domain containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maintenance of postsynaptic density structure, neuron projection development, regulation of ARF protein signal transduction, regulation of postsynapse assembly; MF: guanyl-nucleotide exchange factor activity, phospholipid binding, protein binding; CC: cell junction, cell projection, cleavage furrow, dendritic spine, glutamatergic synapse, membrane, plasma membrane, postsynaptic density, postsynaptic density, intracellular component, ruffle, ruffle membrane
Pathways: Endocytosis - Mus musculus (mouse)
UniProt: Q5DTT2
Entrez ID: 73728
|
Does Knockout of Asf1a in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,546
|
Knockout
|
Asf1a
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Asf1a (anti-silencing function 1A histone chaperone)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, DNA replication-dependent chromatin assembly, chromatin organization, double-strand break repair via homologous recombination, muscle cell differentiation, nucleosome assembly, osteoblast differentiation, protein localization to chromatin, replication fork processing; MF: chromatin binding, histone binding, histone chaperone activity; CC: chromatin, chromosome, nucleoplasm, nucleus, protein-containing complex, site of double-strand break
Pathways: Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, DNA Damage/Telomere Stress Induced Senescence, Formation of Senescence-Associated Heterochromatin Foci (SAHF)
UniProt: Q9CQE6
Entrez ID: 66403
|
Does Knockout of Phox2b in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Phox2b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Phox2b (paired-like homeobox 2b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autonomic nervous system development, brainstem development, cell development, cell differentiation in hindbrain, cellular response to BMP stimulus, cellular response to carbon dioxide, dopaminergic neuron differentiation, efferent axon development in a lateral line nerve, enteric nervous system development, glial cell differentiation, hindbrain tangential cell migration, inner ear development, medullary reticular formation development, membrane depolarization, motor neuron migration, negative regulation of neuron differentiation, negative regulation of type B pancreatic cell proliferation, neural crest cell migration involved in autonomic nervous system development, neural nucleus development, neuron development, neuron differentiation, noradrenergic neuron development, noradrenergic neuron differentiation, parasympathetic nervous system development, positive regulation of cold-induced thermogenesis, positive regulation of neuron differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of gene expression, regulation of respiratory gaseous exchange, regulation of respiratory gaseous exchange by nervous system process, regulation of transcription by RNA polymerase II, respiratory system development, response to activity, retrotrapezoid nucleus neuron differentiation, skeletal muscle cell differentiation, sympathetic ganglion development, sympathetic nervous system development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleoplasm, nucleus
Pathways:
UniProt: O35690
Entrez ID: 18935
|
Does Knockout of Fabp5 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Fabp5
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Fabp5 (fatty acid binding protein 5, epidermal)
Type: protein-coding
Summary: The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. In humans this gene has been associated with psoriasis and type 2 diabetes. In mouse deficiency of this gene in combination with a deficiency in Fabp4 confers protection against atherosclerosis, diet-induced obesity, insulin resistance and experimental autoimmune encephalomyelitis (the mouse model for multiple sclerosis). Alternative splicing results in multiple transcript variants that encode different protein isoforms. The mouse genome contains many pseudogenes similar to this locus. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: fatty acid transport, glucose homeostasis, glucose metabolic process, lipid metabolic process, lipid transport, lipid transport across blood-brain barrier, long-chain fatty acid transport, negative regulation of D-glucose transmembrane transport, phosphatidylcholine biosynthetic process, positive regulation of cold-induced thermogenesis, positive regulation of peroxisome proliferator activated receptor signaling pathway, regulation of prostaglandin biosynthetic process, regulation of retrograde trans-synaptic signaling by endocanabinoid, regulation of sensory perception of pain, retrograde trans-synaptic signaling by endocannabinoid; MF: fatty acid binding, identical protein binding, lipid binding, long-chain fatty acid transmembrane transporter activity, retinoic acid binding; CC: cytoplasm, cytosol, extracellular region, extracellular space, glutamatergic synapse, nucleus, postsynaptic cytosol, postsynaptic density, postsynaptic density, intracellular component, synapse
Pathways: Immune System, Innate Immune System, Metabolism, Metabolism of lipids, Neutrophil degranulation, PPAR signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid, Triglyceride catabolism, Triglyceride metabolism
UniProt: Q05816
Entrez ID: 16592
|
Does Knockout of Pkn2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Pkn2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pkn2 (protein kinase N2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apical junction assembly, apoptotic process, cell adhesion, cell division, cell projection organization, epithelial cell migration, intracellular signal transduction, positive regulation of cytokinesis, positive regulation of mitotic cell cycle, positive regulation of viral genome replication, protein phosphorylation, regulation of cell motility, signal transduction; MF: ATP binding, RNA polymerase binding, diacylglycerol-dependent serine/threonine kinase activity, histone deacetylase binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, small GTPase binding, transferase activity; CC: anchoring junction, apical junction complex, cell projection, centrosome, cleavage furrow, cytoplasm, cytoskeleton, cytosol, intermediate filament cytoskeleton, lamellipodium, membrane, midbody, nuclear body, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, protein-containing complex
Pathways: Cellular responses to mechanical stimuli, Cellular responses to stimuli, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, NOD-like receptor signaling pathway - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), RAC1 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases activate PKNs, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, Response of endothelial cells to shear stress, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Yersinia infection - Mus musculus (mouse)
UniProt: Q8BWW9
Entrez ID: 109333
|
Does Knockout of Jrkl in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Jrkl
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Jrkl (Jrk-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, molecular_function, nucleic acid binding; CC: nucleus
Pathways:
UniProt: B2RRL2
Entrez ID: 77532
|
Does Knockout of Map10 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Map10
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Map10 (microtubule-associated protein 10)
Type: protein-coding
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization; positive regulation of cytokinesis; and regulation of microtubule-based process. Predicted to be active in microtubule cytoskeleton and midbody. Orthologous to human MAP10 (microtubule associated protein 10). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cell division, cytoplasmic microtubule organization, microtubule cytoskeleton organization, mitotic spindle midzone assembly, positive regulation of cytokinesis, regulation of microtubule-based process; MF: microtubule binding; CC: centrosome, cytoplasm, cytoplasmic microtubule, cytoskeleton, midbody, mitotic spindle midzone, mitotic spindle pole, spindle pole
Pathways:
UniProt: Q8BJS7
Entrez ID: 74393
|
Does Knockout of Egr1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Egr1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Egr1 (early growth response 1)
Type: protein-coding
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and enzyme binding activity. Involved in several processes, including cellular response to gamma radiation; circadian temperature homeostasis; and regulation of biosynthetic process. Acts upstream of or within several processes, including BMP signaling pathway; cellular response to hypoxia; and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including brain; embryo mesenchyme; eye; genitourinary system; and jaw. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in asthma. Orthologous to human EGR1 (early growth response 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: BMP signaling pathway, T cell differentiation, cellular response to gamma radiation, cellular response to heparin, cellular response to hypoxia, cellular response to interleukin-8, cellular response to mycophenolic acid, circadian regulation of gene expression, circadian temperature homeostasis, estrous cycle, glomerular mesangial cell proliferation, interleukin-1-mediated signaling pathway, learning or memory, locomotor rhythm, long-term memory, negative regulation of canonical Wnt signaling pathway, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of chemokine production, positive regulation of gene expression, positive regulation of gene expression via chromosomal CpG island demethylation, positive regulation of glomerular metanephric mesangial cell proliferation, positive regulation of hormone biosynthetic process, positive regulation of interleukin-1 beta production, positive regulation of miRNA transcription, positive regulation of neuron apoptotic process, positive regulation of post-translational protein modification, positive regulation of smooth muscle cell migration, positive regulation of smooth muscle cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of long-term neuronal synaptic plasticity, regulation of neuron apoptotic process, regulation of progesterone biosynthetic process, regulation of protein sumoylation, regulation of transcription by RNA polymerase II, response to glucose, response to hypoxia, response to insulin, response to ischemia, rhythmic process, skeletal muscle cell differentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, double-stranded DNA binding, double-stranded methylated DNA binding, enzyme binding, hemi-methylated DNA-binding, histone acetyltransferase binding, metal ion binding, promoter-specific chromatin binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, zinc ion binding; CC: chromatin, cytoplasm, nucleoplasm, nucleus
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Prion disease - Mus musculus (mouse)
UniProt: P08046
Entrez ID: 13653
|
Does Knockout of Tbc1d10c in Non-Small Cell Lung Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,189
|
Knockout
|
Tbc1d10c
|
tumorigenicity
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: Tbc1d10c (TBC1 domain family, member 10c)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of B cell activation, negative regulation of ERK1 and ERK2 cascade, negative regulation of calcineurin-NFAT signaling cascade, retrograde transport, endosome to Golgi; MF: GTPase activator activity; CC: cytosol, filopodium membrane, plasma membrane
Pathways: Immune System, Innate Immune System, Membrane Trafficking, Neutrophil degranulation, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: Q8C9V1
Entrez ID: 108995
|
Does Knockout of Cd22 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Cd22
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Cd22 (CD22 antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, cell adhesion, cell surface receptor signaling pathway, negative regulation of B cell receptor signaling pathway, negative regulation of calcium-mediated signaling, negative regulation of immune system process, negative regulation of immunoglobulin production, negative regulation of signal transduction, regulation of B cell proliferation, regulation of endocytosis, regulation of immune response; MF: CD4 receptor binding, carbohydrate binding, coreceptor activity, protein binding, protein phosphatase binding, sialic acid binding, signaling receptor binding; CC: cell surface, early endosome, external side of plasma membrane, membrane, neuronal cell body membrane, plasma membrane, recycling endosome
Pathways: Adaptive Immune System, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, B cell receptor signaling pathway - Mus musculus (mouse), CD22 mediated BCR regulation, Cell adhesion molecules - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Signaling by the B Cell Receptor (BCR)
UniProt: P35329
Entrez ID: 12483
|
Does Knockout of Trpc1 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Trpc1
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Trpc1 (transient receptor potential cation channel, subfamily C, member 1)
Type: protein-coding
Summary: Enables store-operated calcium channel activity. Acts upstream of or within saliva secretion. Located in basolateral plasma membrane; membrane raft; and myofibril. Part of protein-containing complex. Is expressed in cochlea; dorsal root ganglion; skeletal muscle; spinal cord; and vagus ganglion. Orthologous to human TRPC1 (transient receptor potential cation channel subfamily C member 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, ligand-gated ion channel signaling pathway, melanin biosynthetic process, modulation of chemical synaptic transmission, monoatomic ion transmembrane transport, monoatomic ion transport, phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of insulin secretion, positive regulation of release of sequestered calcium ion into cytosol, regulation of cytosolic calcium ion concentration, response to calcium ion, saliva secretion, transmembrane transport; MF: ATPase binding, calcium channel activity, inositol 1,4,5 trisphosphate binding, metal ion binding, monoatomic cation channel activity, monoatomic ion channel activity, protein binding, signaling receptor binding, store-operated calcium channel activity, transmembrane transporter binding; CC: basolateral plasma membrane, cation channel complex, costamere, cytoplasm, membrane, membrane raft, plasma membrane, postsynaptic membrane, presynaptic membrane, protein-containing complex, receptor complex, sarcomere, synapse
Pathways: Adaptive Immune System, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, Axon guidance - Mus musculus (mouse), Cardiac conduction, Glutamatergic synapse - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), Immune System, Ion channel transport, Ion homeostasis, Muscle contraction, Pancreatic secretion - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Signaling by the B Cell Receptor (BCR), Stimuli-sensing channels, TRP channels, Transport of small molecules
UniProt: Q61056
Entrez ID: 22063
|
Does Knockout of Kcns1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Kcns1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Kcns1 (K+ voltage-gated channel, subfamily S, 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: action potential, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, protein homooligomerization, regulation of potassium ion transmembrane transport, transmembrane transport; MF: monoatomic ion channel activity, potassium channel activity, potassium channel regulator activity, voltage-gated potassium channel activity; CC: membrane, monoatomic ion channel complex, nucleoplasm, perinuclear region of cytoplasm, plasma membrane, voltage-gated potassium channel complex
Pathways: Neuronal System, Potassium Channels, Voltage gated Potassium channels
UniProt: O35173
Entrez ID: 16538
|
Does Knockout of Lonrf1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Lonrf1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Lonrf1 (LON peptidase N-terminal domain and ring finger 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, zinc ion binding
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: D3YY23
Entrez ID: 244421
|
Does Knockout of Zcchc2 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Zcchc2
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Zcchc2 (zinc finger, CCHC domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, nucleic acid binding, phosphatidylinositol binding, zinc ion binding; CC: cytoplasm
Pathways:
UniProt: Q69ZB8
Entrez ID: 227449
|
Does Knockout of Numb in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Numb
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Numb (NUMB endocytic adaptor protein)
Type: protein-coding
Summary: This gene encodes a conserved protein that is distributed asymmetrically during cell division in the developing embryo. The encoded protein participates in cell fate decisions by interacting with the Notch receptor. Loss of function of this gene results in severe defects in neural development and loss of viability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: adherens junction organization, axonogenesis, forebrain development, lateral ventricle development, negative regulation of protein localization to plasma membrane, nervous system development, neuroblast division in subventricular zone, neuroblast proliferation, positive regulation of cell migration, positive regulation of dendrite morphogenesis, positive regulation of neurogenesis, regulation of neuron differentiation, regulation of postsynapse assembly, regulation of postsynaptic neurotransmitter receptor internalization; MF: alpha-catenin binding, beta-catenin binding, cadherin binding, phospholipid binding, protein binding; CC: apical part of cell, basolateral plasma membrane, clathrin-coated pit, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, dendritic spine, early endosome, endosome, endosome membrane, glutamatergic synapse, membrane, nucleus, plasma membrane, postsynaptic density
Pathways: Notch signaling pathway - Mus musculus (mouse)
UniProt: Q9QZS3
Entrez ID: 18222
|
Does Knockout of Cep83 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Cep83
|
phagocytosis
|
macrophage
|
Gene: Cep83 (centrosomal protein 83)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cilium assembly, establishment of centrosome localization, protein localization to centrosome, vesicle docking; CC: Golgi apparatus, centriole, centrosome, ciliary transition fiber, cytoplasm, cytoskeleton
Pathways: Anchoring of the basal body to the plasma membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: Q9D5R3
Entrez ID: 77048
|
Does Knockout of Caprin2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Caprin2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Caprin2 (caprin family member 2)
Type: protein-coding
Summary: This gene encodes a member of the caprin family. The encoded protein may function as an RNA-binding protein that induces the formation of RNA granules and plays an important role in brain function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014].
Gene Ontology: BP: cell differentiation, negative regulation of cell growth, negative regulation of translation, positive regulation of canonical Wnt signaling pathway, positive regulation of dendrite morphogenesis, positive regulation of dendritic spine morphogenesis, positive regulation of transcription by RNA polymerase II; MF: RNA binding, metal ion binding, signaling receptor binding; CC: centrosome, cytoplasm, cytosol, membrane, mitochondrion, nucleoplasm, plasma membrane, receptor complex
Pathways:
UniProt: Q05A80
Entrez ID: 232560
|
Does Knockout of Mturn in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Mturn
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mturn (maturin, neural progenitor differentiation regulator homolog (Xenopus))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of NF-kappaB transcription factor activity, neuron development, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of megakaryocyte differentiation, regulation of signaling; CC: cytoplasm
Pathways:
UniProt: Q8CGA4
Entrez ID: 68235
|
Does Knockout of Stat1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,283
|
Knockout
|
Stat1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Stat1 (signal transducer and activator of transcription 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, blood circulation, cell population proliferation, cell surface receptor signaling pathway via JAK-STAT, cell surface receptor signaling pathway via STAT, cellular response to cytokine stimulus, cellular response to interferon-beta, cellular response to lipopolysaccharide, cellular response to type II interferon, cytokine-mediated signaling pathway, defense response, defense response to virus, interleukin-27-mediated signaling pathway, interleukin-7-mediated signaling pathway, interleukin-9-mediated signaling pathway, lipopolysaccharide-mediated signaling pathway, metanephric mesenchymal cell differentiation, metanephric mesenchymal cell proliferation involved in metanephros development, negative regulation by virus of viral protein levels in host cell, negative regulation of angiogenesis, negative regulation of canonical NF-kappaB signal transduction, negative regulation of developmental process, negative regulation of endothelial cell proliferation, negative regulation of macrophage fusion, negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis, negative regulation of metanephric nephron tubule epithelial cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of defense response to virus by host, positive regulation of erythrocyte differentiation, positive regulation of interferon-alpha production, positive regulation of mesenchymal cell proliferation, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of smooth muscle cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell population proliferation, regulation of transcription by RNA polymerase II, renal tubule development, response to bacterium, response to cAMP, response to cytokine, response to exogenous dsRNA, response to interferon-beta, response to lipopolysaccharide, response to peptide hormone, response to type I interferon, response to type II interferon, signal transduction, tumor necrosis factor-mediated signaling pathway, type I interferon-mediated signaling pathway, type II interferon-mediated signaling pathway; MF: CCR5 chemokine receptor binding, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, double-stranded DNA binding, enzyme binding, histone acetyltransferase binding, histone binding, identical protein binding, promoter-specific chromatin binding, protein binding, protein homodimerization activity, protein phosphatase 2A binding, sequence-specific DNA binding, transcription coactivator binding, transcription corepressor binding, tumor necrosis factor receptor binding, ubiquitin-like protein ligase binding; CC: ISGF3 complex, RNA polymerase II transcription regulator complex, axon, chromatin, cytoplasm, cytosol, dendrite, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Inflammatory bowel disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Toll-like receptor signaling pathway - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q8C3V4, Q99K94, Q8CFQ1, Q8C8M3, Q8C497, A0A087WSP5, A0A087WRI1, A0A087WSQ5
Entrez ID: 20846
|
Does Knockout of Vmn1r101 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Vmn1r101
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vmn1r101 (vomeronasal 1 receptor 101)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: E9Q365
Entrez ID: 100042968
|
Does Knockout of Fam174b in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Fam174b
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Fam174b (family with sequence similarity 174, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization; CC: Golgi apparatus, membrane, plasma membrane
Pathways:
UniProt: Q8K064
Entrez ID: 100038347
|
Does Knockout of Prickle4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Prickle4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Prickle4 (prickle planar cell polarity protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, heart development, muscle structure development; MF: actin binding, muscle alpha-actinin binding; CC: Z disc, adherens junction, filamentous actin, stress fiber
Pathways: Wnt signaling pathway - Mus musculus (mouse)
UniProt: F6R2T0, D3Z6Q6, F6ZPB0
Entrez ID: 381104
|
Does Knockout of Sele in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Sele
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Sele (selectin, endothelial cell)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament-based process, cell adhesion, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, leukocyte cell-cell adhesion, leukocyte tethering or rolling, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of leukocyte migration, positive regulation of leukocyte tethering or rolling, positive regulation of receptor internalization, response to cytokine, response to interleukin-1; MF: calcium ion binding, carbohydrate binding, metal ion binding, oligosaccharide binding, phospholipase binding, sialic acid binding, transmembrane signaling receptor activity; CC: caveola, clathrin-coated pit, cortical cytoskeleton, external side of plasma membrane, extracellular space, membrane, membrane raft, perinuclear region of cytoplasm, plasma membrane
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), African trypanosomiasis - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Cell surface interactions at the vascular wall, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Hemostasis, Lipid and atherosclerosis - Mus musculus (mouse), Malaria - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse)
UniProt: Q00690
Entrez ID: 20339
|
Does Knockout of Tnfrsf17 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Tnfrsf17
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tnfrsf17 (tumor necrosis factor receptor superfamily, member 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, immune system process, lymphocyte homeostasis, tumor necrosis factor-mediated signaling pathway
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Intestinal immune network for IgA production - Mus musculus (mouse), TNFR2 non-canonical NF-kB pathway, TNFs bind their physiological receptors
UniProt: O88472
Entrez ID: 21935
|
Does Knockout of Prorsd1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Prorsd1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Prorsd1 (prolyl-tRNA synthetase domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aminoacyl-tRNA metabolism involved in translational fidelity, biological_process, tRNA metabolic process; MF: aminoacyl-tRNA deacylase activity, molecular_function
Pathways:
UniProt: Q9D820
Entrez ID: 67939
|
Does Knockout of Camk2d in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,663
|
Knockout
|
Camk2d
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Camk2d (calcium/calmodulin-dependent protein kinase II, delta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, calcium ion transport, cardiac muscle cell contraction, cardiac muscle contraction, cell growth involved in cardiac muscle cell development, endoplasmic reticulum calcium ion homeostasis, establishment of localization in cell, intracellular potassium ion homeostasis, negative regulation of sodium ion transmembrane transport, positive regulation of DNA biosynthetic process, positive regulation of ERK1 and ERK2 cascade, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of Rac protein signal transduction, positive regulation of cardiac muscle cell apoptotic process, positive regulation of cardiac muscle hypertrophy, positive regulation of smooth muscle cell migration, positive regulation of vascular associated smooth muscle cell proliferation, protein phosphorylation, regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, regulation of cardiac muscle cell action potential, regulation of cell communication by electrical coupling, regulation of cellular localization, regulation of membrane depolarization, regulation of neuronal synaptic plasticity, regulation of protein localization to plasma membrane, regulation of relaxation of cardiac muscle, regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, regulation of sodium ion transport, relaxation of cardiac muscle, response to hypoxia; MF: ATP binding, calcium/calmodulin-dependent protein kinase activity, calmodulin binding, identical protein binding, kinase activity, nitric-oxide synthase binding, nucleotide binding, protein binding, protein homodimerization activity, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, sodium channel inhibitor activity, titin binding, transferase activity, transmembrane transporter binding; CC: T-tubule, axon initial segment, calcium- and calmodulin-dependent protein kinase complex, cochlear hair cell ribbon synapse, cytoplasm, intercalated disc, membrane, neuromuscular junction, neuron projection, neuronal cell body, nucleus, organelle, perinuclear region of cytoplasm, plasma membrane, postsynaptic cytosol, postsynaptic density, protein-containing complex, sarcolemma, sarcoplasmic reticulum, sarcoplasmic reticulum membrane
Pathways: Activation of NMDA receptors and postsynaptic events, Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Axon guidance - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cardiac conduction, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cholinergic synapse - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Cytokine Signaling in Immune system, Diabetic cardiomyopathy - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Glioma - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glutamate binding, activation of AMPA receptors and synaptic plasticity, GnRH signaling pathway - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), HSF1-dependent transactivation, Immune System, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Insulin secretion - Mus musculus (mouse), Interferon Signaling, Interferon gamma signaling, Ion channel transport, Ion homeostasis, Ion transport by P-type ATPases, Lipid and atherosclerosis - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, Melanogenesis - Mus musculus (mouse), Muscle contraction, Necroptosis - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Neurotrophin signaling pathway - Mus musculus (mouse), Olfactory transduction - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RAF activation, RAF/MAP kinase cascade, Signal Transduction, Trafficking of AMPA receptors, Transmission across Chemical Synapses, Transport of small molecules, Tuberculosis - Mus musculus (mouse), Unblocking of NMDA receptors, glutamate binding and activation, Wnt signaling pathway - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q6PHZ2
Entrez ID: 108058
|
Does Knockout of Krt8 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Krt8
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Krt8 (keratin 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation involved in embryonic placenta development, extrinsic apoptotic signaling pathway, hepatocyte apoptotic process, response to hydrostatic pressure, response to other organism, sarcomere organization, tumor necrosis factor-mediated signaling pathway; MF: protein binding, protein-containing complex binding, scaffold protein binding; CC: Z disc, apicolateral plasma membrane, cell periphery, cell-cell junction, costamere, cytoplasm, dystrophin-associated glycoprotein complex, intermediate filament, intermediate filament cytoskeleton, keratin filament, nuclear matrix, nucleoplasm, nucleus, sarcolemma
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: P11679
Entrez ID: 16691
|
Does Knockout of Parva in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Parva
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Parva (parvin, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin filament-based process, actin-mediated cell contraction, angiogenesis, cell adhesion, cell projection organization, chemotaxis, cilium assembly, establishment or maintenance of cell polarity, establishment or maintenance of cell polarity regulating cell shape, heterotypic cell-cell adhesion, outflow tract septum morphogenesis, regulation of cell shape, smooth muscle cell chemotaxis, sprouting angiogenesis, substrate adhesion-dependent cell spreading; MF: actin binding, protein binding, protein kinase inhibitor activity, protein-containing complex binding; CC: Z disc, actin cytoskeleton, anchoring junction, cytoplasm, cytoskeleton, cytosol, focal adhesion, lamellipodium, membrane, nucleus, plasma membrane, protein-containing complex
Pathways: Cell junction organization, Cell-Cell communication, Cell-extracellular matrix interactions, Focal adhesion - Mus musculus (mouse), Localization of the PINCH-ILK-PARVIN complex to focal adhesions, Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
UniProt: Q9EPC1
Entrez ID: 57342
|
Does Knockout of Rps19bp1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Rps19bp1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Rps19bp1 (ribosomal protein S19 binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, ribosomal small subunit biogenesis; MF: enzyme binding, protein binding; CC: cytosol, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Regulation of HSF1-mediated heat shock response
UniProt: Q8C6B9
Entrez ID: 66538
|
Does Knockout of Vmn1r65 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Vmn1r65
|
cell proliferation
|
Regulatory T cell
|
Gene: Vmn1r65 (vomeronasal 1 receptor 65)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: Q9EPS7
Entrez ID: 81013
|
Does Knockout of Zfp458 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Zfp458
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Zfp458 (zinc finger protein 458)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: metal ion binding, sequence-specific DNA binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q6P5C7
Entrez ID: 238690
|
Does Knockout of Nxph2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Nxph2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nxph2 (neurexophilin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: signaling receptor binding
Pathways:
UniProt: Q61199
Entrez ID: 18232
|
Does Knockout of Zfp457 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Zfp457
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Zfp457 (zinc finger protein 457)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, metal ion binding, sequence-specific DNA binding, zinc ion binding; CC: membrane, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q7M6X7, L7N1X4, A0A286YD33, A0A286YD11
Entrez ID: 431706
|
Does Knockout of Zbtb14 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Zbtb14
|
response to virus
|
Microglial Cell Line
|
Gene: Zbtb14 (zinc finger and BTB domain containing 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac septum development, coronary vasculature development, heart valve development, kidney development, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, zinc ion binding; CC: aggresome, cytosol, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q08376
Entrez ID: 22666
|
Does Knockout of Alg9 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Alg9
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Alg9 (ALG9 alpha-1,2-mannosyltransferase)
Type: protein-coding
Summary: Predicted to enable dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity and dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in cortical plate. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Il. Orthologous to human ALG9 (ALG9 alpha-1,2-mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation, protein glycosylation; MF: alpha-1,2-mannosyltransferase activity, dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity, dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity, glycosyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, N-Glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification, Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: Q8VDI9
Entrez ID: 102580
|
Does Knockout of Gde1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Gde1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gde1 (glycerophosphodiester phosphodiesterase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, N-acylethanolamine metabolic process, ethanolamine metabolic process, lipid metabolic process, phospholipid metabolic process; MF: glycerophosphodiester phosphodiesterase activity, glycerophosphoinositol glycerophosphodiesterase activity, hydrolase activity, metal ion binding, phosphatidylcholine lysophospholipase activity, phosphoric diester hydrolase activity; CC: cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane, plasma membrane
Pathways: Glycerophospholipid catabolism, Metabolism, Metabolism of lipids, PI Metabolism, Phospholipid metabolism
UniProt: Q9JL56
Entrez ID: 56209
|
Does Knockout of Arpc3 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Arpc3
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Arpc3 (actin related protein 2/3 complex, subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation, regulation of actin filament polymerization, regulation of synaptic vesicle endocytosis; MF: actin binding, actin filament binding, protein binding, structural constituent of cytoskeleton; CC: Arp2/3 protein complex, cell leading edge, cell projection, cytoplasm, cytoskeleton, filamentous actin, growth cone leading edge, lamellipodium, nucleus, site of double-strand break
Pathways: Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Clathrin-mediated endocytosis, Developmental Biology, EPH-Ephrin signaling, EPHB-mediated forward signaling, Endocytosis - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, Membrane Trafficking, Nervous system development, RHO GTPase Effectors, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Mus musculus (mouse), Vesicle-mediated transport, Yersinia infection - Mus musculus (mouse)
UniProt: Q9JM76
Entrez ID: 56378
|
Does Knockout of Borcs5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Borcs5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Borcs5 (BLOC-1 related complex subunit 5)
Type: protein-coding
Summary: Acts upstream of or within nervous system development and organelle transport along microtubule. Is active in axon and lysosome. Is expressed in brain; heart; lung; and metanephros. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human BORCS5 (BLOC-1 related complex subunit 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: lysosome localization, nervous system development, organelle transport along microtubule, positive regulation of anterograde synaptic vesicle transport, regulation of endosome size, regulation of lysosome size; CC: BORC complex, axon, cytoplasmic side of lysosomal membrane, lysosomal membrane, lysosome, membrane, plasma membrane, plus-end kinesin complex, synaptic vesicle membrane
Pathways:
UniProt: Q9D920
Entrez ID: 67774
|
Does Knockout of 2310061I04Rik in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
2310061I04Rik
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: 2310061I04Rik (RIKEN cDNA 2310061I04 gene)
Type: protein-coding
Summary: Located in mitochondrion. Is expressed in several structures, including adrenal gland; gonad; liver; lung; and spleen. Orthologous to human C6orf136 (chromosome 6 open reading frame 136). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: B8JJ69, B8JJ66, F6X1P1, B8JJ67, B8JJ68, F6W3U3
Entrez ID: 69662
|
Does Knockout of 6030469F06Rik in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
6030469F06Rik
|
cell proliferation
|
Melanoma Cell Line
|
Gene: 6030469F06Rik (RIKEN cDNA 6030469F06 gene)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100043065
|
Does Knockout of Ebf4 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Ebf4
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Ebf4 (early B cell factor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell apoptotic process, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: chromatin, nucleus
Pathways:
UniProt: Q8K4J2
Entrez ID: 228598
|
Does Knockout of Cetn2 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,523
|
Knockout
|
Cetn2
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Cetn2 (centrin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, cell division, centriole replication, mRNA transport, microtubule cytoskeleton organization, nucleotide-excision repair, protein transport, regulation of cytokinesis, spermatogenesis; MF: G-protein beta/gamma-subunit complex binding, calcium ion binding, heterotrimeric G-protein binding, metal ion binding, microtubule binding; CC: 9+2 motile cilium, XPC complex, apical part of cell, centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, glial cell projection, microtubule organizing center, nuclear envelope, nuclear pore, nuclear pore nuclear basket, nucleus, photoreceptor connecting cilium, transcription export complex 2
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, DNA Damage Recognition in GG-NER, DNA Repair, Formation of Incision Complex in GG-NER, G2/M Transition, Global Genome Nucleotide Excision Repair (GG-NER), Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Metabolism of proteins, Mitotic G2-G2/M phases, Mitotic Prometaphase, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), Organelle biogenesis and maintenance, Post-translational protein modification, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins
UniProt: Q9R1K9
Entrez ID: 26370
|
Does Knockout of Foxo6 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Foxo6
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Foxo6 (forkhead box O6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: memory, positive regulation of dendritic spine development, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding; CC: cytoplasm, nucleoplasm, nucleus
Pathways: AKT phosphorylates targets in the nucleus, FOXO-mediated transcription, FoxO signaling pathway - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Intracellular signaling by second messengers, PIP3 activates AKT signaling, RNA Polymerase II Transcription, Regulation of localization of FOXO transcription factors, Signal Transduction
UniProt: Q70KY4
Entrez ID: 329934
|
Does Knockout of Dlx2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Dlx2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dlx2 (distal-less homeobox 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GABAergic neuron differentiation, branching morphogenesis of a nerve, cartilage development, cell differentiation, cerebral cortex GABAergic interneuron differentiation, cerebral cortex GABAergic interneuron fate commitment, embryonic cranial skeleton morphogenesis, embryonic skeletal system development, forebrain neuron differentiation, forebrain neuron fate commitment, hippocampus development, negative regulation of Notch signaling pathway, negative regulation of oligodendrocyte differentiation, negative regulation of photoreceptor cell differentiation, negative regulation of transcription by RNA polymerase II, neuroblast differentiation, odontogenesis of dentin-containing tooth, olfactory bulb development, positive regulation of amacrine cell differentiation, positive regulation of cell differentiation, positive regulation of transcription by RNA polymerase II, proximal/distal pattern formation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, subpallium development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, protein binding, sequence-specific double-stranded DNA binding, single-stranded RNA binding, transcription cis-regulatory region binding; CC: nucleus
Pathways:
UniProt: P40764
Entrez ID: 13392
|
Does Knockout of Inpp4b in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Inpp4b
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Inpp4b (inositol polyphosphate-4-phosphatase, type II)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular calcium ion homeostasis, lipid metabolic process, negative regulation of osteoclast differentiation, phosphatidylinositol dephosphorylation, phosphatidylinositol-3-phosphate biosynthetic process, regulation of bone remodeling, regulation of nucleocytoplasmic transport, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; MF: hydrolase activity, inositol-1,3,4-trisphosphate 4-phosphatase activity, inositol-3,4-bisphosphate 4-phosphatase activity, lipid binding, phosphatase activity, phosphatidylinositol bisphosphate phosphatase activity, phosphatidylinositol trisphosphate phosphatase activity, phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
Pathways: Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, PI Metabolism, PIP metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, Synthesis of IP2, IP, and Ins in the cytosol, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the plasma membrane
UniProt: Q6P1Y8
Entrez ID: 234515
|
Does Knockout of Fbxw25 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Fbxw25
|
phagocytosis
|
macrophage
|
Gene: Fbxw25 (F-box and WD-40 domain protein 25)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, cytoplasm
Pathways:
UniProt: F7C9P2
Entrez ID: 546160
|
Does Knockout of Ccnb1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Ccnb1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ccnb1 (cyclin B1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, cell division, cellular response to fatty acid, cellular response to hypoxia, cellular response to iron(III) ion, digestive tract development, in utero embryonic development, mitotic cell cycle phase transition, mitotic metaphase chromosome alignment, mitotic spindle organization, negative regulation of gene expression, oocyte maturation, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of attachment of spindle microtubules to kinetochore, positive regulation of cardiac muscle cell proliferation, positive regulation of cell cycle, positive regulation of fibroblast proliferation, positive regulation of mRNA 3'-end processing, positive regulation of mitochondrial ATP synthesis coupled electron transport, positive regulation of mitotic cell cycle, protein-containing complex assembly, regulation of chromosome condensation, regulation of mitotic cell cycle spindle assembly checkpoint, response to DDT, response to mechanical stimulus, response to toxic substance, response to xenobiotic stimulus, spermatogenesis, tissue regeneration, ventricular cardiac muscle cell development; MF: cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase regulator activity, patched binding, protein binding, protein kinase binding, protein-containing complex binding, ubiquitin-like protein ligase binding; CC: centrosome, cyclin B1-CDK1 complex, cytoplasm, cytoskeleton, cytosol, membrane, microtubule organizing center, mitochondrial matrix, nucleus, outer kinetochore, spindle pole
Pathways: APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NIMA Kinases NEK9, NEK6, NEK7, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, Condensation of Prophase Chromosomes, Cyclin A/B1/B2 associated events during G2/M transition, Depolymerization of the Nuclear Lamina, FoxO signaling pathway - Mus musculus (mouse), G2/M Checkpoints, G2/M DNA damage checkpoint, G2/M DNA replication checkpoint, G2/M Transition, Gene expression (Transcription), Generic Transcription Pathway, Human immunodeficiency virus 1 infection - Mus musculus (mouse), Initiation of Nuclear Envelope (NE) Reformation, M Phase, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Oocyte meiosis - Mus musculus (mouse), Phosphorylation of Emi1, Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of PLK1 Activity at G2/M Transition, Regulation of mitotic cell cycle, Resolution of Sister Chromatid Cohesion, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional Regulation by TP53, Transcriptional regulation by RUNX2, p53 signaling pathway - Mus musculus (mouse)
UniProt: P24860
Entrez ID: 268697
|
Does Knockout of Armcx6 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Armcx6
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Armcx6 (armadillo repeat containing, X-linked 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, mitochondrial outer membrane, mitochondrion
Pathways:
UniProt: Q8K3A6
Entrez ID: 278097
|
Does Knockout of Pptc7 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Pptc7
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Pptc7 (PTC7 protein phosphatase homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitophagy, negative regulation of mitophagy, positive regulation of ubiquinone biosynthetic process, regulation of ubiquinone biosynthetic process; MF: hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity, protein-macromolecule adaptor activity; CC: mitochondrial matrix, mitochondrial outer membrane, mitochondrion
Pathways:
UniProt: Q6NVE9
Entrez ID: 320717
|
Does Knockout of Junb in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,663
|
Knockout
|
Junb
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Junb (jun B proto-oncogene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to calcium ion, decidualization, embryonic process involved in female pregnancy, in utero embryonic development, labyrinthine layer blood vessel development, osteoblast differentiation, osteoblast proliferation, osteoclast differentiation, osteoclast proliferation, positive regulation of cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell population proliferation, response to steroid hormone, transcription by RNA polymerase II, trophectodermal cell differentiation, vasculogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, double-stranded DNA binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription regulator complex, nucleoplasm, nucleus, transcription factor AP-1 complex, transcription regulator complex
Pathways: Growth hormone synthesis, secretion and action - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse)
UniProt: P09450
Entrez ID: 16477
|
Does Knockout of Gpr85 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Gpr85
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gpr85 (G protein-coupled receptor 85)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: endoplasmic reticulum, membrane, plasma membrane
Pathways:
UniProt: P60894
Entrez ID: 64450
|
Does Knockout of Cntn3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Cntn3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cntn3 (contactin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, neuron projection development; CC: membrane, neuron projection, plasma membrane, side of membrane
Pathways: Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q07409
Entrez ID: 18488
|
Does Knockout of Osgepl1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Osgepl1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Osgepl1 (O-sialoglycoprotein endopeptidase-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: tRNA processing, tRNA threonylcarbamoyladenosine modification; MF: acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, metal ion binding, tRNA N(6)-L-threonylcarbamoyladenine synthase activity, transferase activity; CC: mitochondrion
Pathways:
UniProt: Q6PEB4
Entrez ID: 72085
|
Does Knockout of Spata31 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Spata31
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Spata31 (spermatogenesis associated 31)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell differentiation, spermatogenesis; MF: actin binding, molecular_function; CC: acrosomal lumen, acrosomal membrane, acrosomal vesicle, cytoplasmic vesicle, membrane
Pathways:
UniProt: E9QAF0
Entrez ID: 78124
|
Does Knockout of Sbpl in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Sbpl
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Sbpl (spermine binding protein-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell migration; MF: carbohydrate binding, molecular_function; CC: apicolateral plasma membrane, cytoplasm, extracellular region, extracellular space, plasma membrane
Pathways:
UniProt: Q3TUY3, Q9CPP2
Entrez ID: 638345
|
Does Knockout of Nlrp4e in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Nlrp4e
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Nlrp4e (NLR family, pyrin domain containing 4E)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, biological_process, inflammatory response, negative regulation of innate immune response, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K33-linked deubiquitination, protein K48-linked ubiquitination, regulation of inflammatory response; MF: ATP binding, molecular adaptor activity, molecular_function, nucleotide binding; CC: cytoplasm
Pathways:
UniProt: Q66X19
Entrez ID: 446099
|
Does Knockout of Naif1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Naif1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Naif1 (nuclear apoptosis inducing factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, negative regulation of cell growth, regulation of mitochondrial membrane permeability involved in apoptotic process; CC: cytosol, mitochondrion, nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: Q6PFD7
Entrez ID: 71254
|
Does Knockout of Rec8 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,527
|
Knockout
|
Rec8
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Rec8 (REC8 meiotic recombination protein)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity. Acts upstream of or within several processes, including germ cell development; meiosis I; and seminiferous tubule development. Located in kinetochore; lateral element; and male germ cell nucleus. Part of meiotic cohesin complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human REC8 (REC8 meiotic recombination protein). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chromosome segregation, double-strand break repair, double-strand break repair via homologous recombination, fertilization, homologous chromosome pairing at meiosis, male meiosis I, meiotic cell cycle, meiotic sister chromatid cohesion, oocyte maturation, seminiferous tubule development, sister chromatid cohesion, spermatid development, synaptonemal complex assembly; MF: chromatin binding, protein binding; CC: chromosome, chromosome, centromeric region, cohesin complex, condensed chromosome, condensed chromosome, centromeric region, condensed nuclear chromosome, kinetochore, lateral element, male germ cell nucleus, meiotic cohesin complex, nucleoplasm, nucleus, synaptonemal complex
Pathways: Oocyte meiosis - Mus musculus (mouse)
UniProt: Q8C5S7
Entrez ID: 56739
|
Does Knockout of Cdcp2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Cdcp2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cdcp2 (CUB domain containing protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8BQH6
Entrez ID: 242603
|
Does Knockout of Chchd3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Chchd3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Chchd3 (coiled-coil-helix-coiled-coil-helix domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cristae formation, inner mitochondrial membrane organization, mitochondrial fusion; MF: molecular adaptor activity, phosphatase binding, protein binding; CC: MICOS complex, cytoplasm, membrane, mitochondrial inner membrane, mitochondrion, nucleus
Pathways:
UniProt: Q9CRB9
Entrez ID: 66075
|
Does Knockout of Dlg2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Dlg2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Dlg2 (discs large MAGUK scaffold protein 2)
Type: protein-coding
Summary: A structural constituent of postsynaptic density. Involved in several processes, including axo-dendritic protein transport; clustering of voltage-gated potassium channels; and neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within chemical synaptic transmission and sensory perception of pain. Located in several cellular components, including juxtaparanode region of axon; postsynaptic membrane; and synaptic vesicle membrane. Is active in axon initial segment and glutamatergic synapse. Is expressed in jaw bone; nervous system; and retina. Orthologous to human DLG2 (discs large MAGUK scaffold protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: anterograde axonal protein transport, cell-cell adhesion, cellular response to potassium ion, chemical synaptic transmission, clustering of voltage-gated potassium channels, establishment or maintenance of epithelial cell apical/basal polarity, maintenance of postsynaptic density structure, nervous system development, neuronal ion channel clustering, neurotransmitter receptor localization to postsynaptic specialization membrane, protein localization to synapse, receptor clustering, receptor localization to synapse, regulation of postsynaptic membrane neurotransmitter receptor levels, retrograde axonal protein transport, sensory perception of pain; MF: PDZ domain binding, ionotropic glutamate receptor binding, kinase binding, protein binding, protein kinase binding, protein phosphatase binding, protein-containing complex binding, structural constituent of postsynaptic density; CC: axon, axon cytoplasm, axon initial segment, basolateral plasma membrane, cell junction, cell projection, cytoplasm, dendrite, glutamatergic synapse, juxtaparanode region of axon, membrane, neuromuscular junction, neuron projection, neuronal cell body, nucleus, perikaryon, plasma membrane, postsynaptic density, postsynaptic density membrane, postsynaptic membrane, synapse, synaptic vesicle membrane, voltage-gated potassium channel complex
Pathways: Activation of NMDA receptors and postsynaptic events, Hippo signaling pathway - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, Neurexins and neuroligins, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Protein-protein interactions at synapses, RAF/MAP kinase cascade, Signal Transduction, Tight junction - Mus musculus (mouse), Transmission across Chemical Synapses, Unblocking of NMDA receptors, glutamate binding and activation
UniProt: Q91XM9
Entrez ID: 23859
|
Does Knockout of Vti1b in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Vti1b
|
response to virus
|
Microglial Cell Line
|
Gene: Vti1b (vesicle transport through interaction with t-SNAREs 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to vacuole transport, intra-Golgi vesicle-mediated transport, intracellular protein transport, macroautophagy, protein transport, regulation of protein localization to plasma membrane, retrograde transport, endosome to Golgi, vesicle fusion with Golgi apparatus, vesicle-mediated transport; MF: SNAP receptor activity, SNARE binding, chloride channel inhibitor activity, protein binding; CC: ER to Golgi transport vesicle membrane, Golgi apparatus, SNARE complex, cytoplasm, cytosol, early endosome membrane, endomembrane system, endoplasmic reticulum membrane, endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, neuronal cell body, perinuclear region of cytoplasm, presynaptic endosome membrane, recycling endosome, recycling endosome membrane, synaptic vesicle, vesicle
Pathways: SNARE interactions in vesicular transport - Mus musculus (mouse)
UniProt: F6T4B9, Q91XH6, E0CYE5, F6UHS3
Entrez ID: 53612
|
Does Knockout of Arsg in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Arsg
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Arsg (arylsulfatase G)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: gene expression, glial cell differentiation, homeostasis of number of cells, lysosome organization, neuron apoptotic process, retina development in camera-type eye, sulfur compound metabolic process; MF: N-sulfoglucosamine-3-sulfatase activity, arylsulfatase activity, hydrolase activity, metal ion binding; CC: endoplasmic reticulum, extracellular space, lysosome
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Glycosphingolipid catabolism, Glycosphingolipid metabolism, Lysosome - Mus musculus (mouse), Metabolism, Metabolism of lipids, Metabolism of proteins, Post-translational protein modification, Sphingolipid metabolism, The activation of arylsulfatases
UniProt: Q3TYD4
Entrez ID: 74008
|
Does Knockout of Ccar1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Ccar1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ccar1 (cell division cycle and apoptosis regulator 1)
Type: protein-coding
Summary: Enables transcription coactivator activity. Predicted to be involved in positive regulation of cell migration; positive regulation of cell population proliferation; and regulation of DNA-templated transcription. Predicted to act upstream of or within positive regulation of apoptotic process. Predicted to be located in nuclear envelope lumen. Predicted to be active in nucleus. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human CCAR1 (cell division cycle and apoptosis regulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: apoptotic process, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of cell migration, positive regulation of cell population proliferation, regulation of DNA-templated transcription; MF: RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, transcription coactivator activity, transcription corepressor activity; CC: cytoplasm, nuclear envelope lumen, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: Q8CH18
Entrez ID: 67500
|
Does Knockout of Zbed5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Zbed5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zbed5 (zinc finger BED-type containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8CEW7, B2RPU8, D3Z5B1
Entrez ID: 71970
|
Does Knockout of Zfp770 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Zfp770
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Zfp770 (zinc finger protein 770)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q8BIQ8
Entrez ID: 228491
|
Does Knockout of Lck in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Lck
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Lck (lymphocyte protein tyrosine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell receptor signaling pathway, CD27 signaling pathway, Fc-gamma receptor signaling pathway, T cell activation, T cell differentiation, T cell receptor signaling pathway, cell surface receptor protein tyrosine kinase signaling pathway, cell surface receptor signaling pathway, intracellular signal transduction, intracellular zinc ion homeostasis, positive regulation of MAPK cascade, positive regulation of T cell activation, positive regulation of gamma-delta T cell differentiation, positive regulation of gene expression, positive regulation of heterotypic cell-cell adhesion, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of leukocyte cell-cell adhesion, positive regulation of multicellular organismal process, positive regulation of uterine smooth muscle contraction, regulation of T cell receptor signaling pathway, regulation of regulatory T cell differentiation, release of sequestered calcium ion into cytosol, response to hydrogen peroxide, response to mechanical stimulus, response to metal ion, response to xenobiotic stimulus; MF: ATP binding, ATPase binding, CD4 receptor binding, CD8 receptor binding, SH2 domain binding, T cell receptor binding, antigen binding, identical protein binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, phosphatidylinositol 3-kinase binding, phospholipase activator activity, phospholipase binding, phosphotyrosine residue binding, protein antigen binding, protein binding, protein kinase activity, protein kinase binding, protein phosphatase binding, protein serine/threonine phosphatase activity, protein tyrosine kinase activity, protein-containing complex binding, signaling receptor binding, transferase activity; CC: cell-cell junction, cytoplasm, cytosol, endocytic vesicle, glutamatergic synapse, immunological synapse, membrane, membrane raft, pericentriolar material, plasma membrane, postsynaptic specialization, intracellular component
Pathways: Adaptive Immune System, CD28 dependent PI3K/Akt signaling, CD28 dependent Vav1 pathway, Cell surface interactions at the vascular wall, Co-inhibition by CTLA4, Co-inhibition by PD-1, Co-stimulation by CD28, Cytokine Signaling in Immune system, DAP12 interactions, DAP12 signaling, Downstream TCR signaling, FLT3 Signaling, FLT3 signaling through SRC family kinases, GPVI-mediated activation cascade, Generation of second messenger molecules, Hemostasis, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-2 family signaling, Interleukin-2 signaling, Intracellular signaling by second messengers, NF-kappa B signaling pathway - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Negative regulation of the PI3K/AKT network, Osteoclast differentiation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PECAM1 interactions, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Phosphorylation of CD3 and TCR zeta chains, Platelet activation, signaling and aggregation, Primary immunodeficiency - Mus musculus (mouse), RHO GTPase cycle, RHOH GTPase cycle, Regulation of KIT signaling, Regulation of T cell activation by CD28 family, Signal Transduction, Signaling by Interleukins, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by SCF-KIT, T cell receptor signaling pathway - Mus musculus (mouse), TCR signaling, Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Translocation of ZAP-70 to Immunological synapse, Yersinia infection - Mus musculus (mouse)
UniProt: P06240
Entrez ID: 16818
|
Does Knockout of Polr3g in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Polr3g
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Polr3g (polymerase (RNA) III (DNA directed) polypeptide G)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell population proliferation, defense response to virus, epithelial cell proliferation, immune system process, innate immune response, positive regulation of innate immune response, positive regulation of interferon-beta production, transcription by RNA polymerase III; MF: chromatin binding; CC: RNA polymerase III complex, cytoplasm, cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Cytosolic DNA-sensing pathway - Mus musculus (mouse), Gene expression (Transcription), RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase - Mus musculus (mouse)
UniProt: Q6NXY9
Entrez ID: 67486
|
Does Knockout of Ophn1 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Ophn1
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Ophn1 (oligophrenin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, cell junction assembly, cell morphogenesis involved in neuron differentiation, cerebellar granule cell differentiation, cerebral cortex neuron differentiation, endocytosis, establishment of epithelial cell apical/basal polarity, establishment of localization in cell, maintenance of postsynaptic specialization structure, negative regulation of proteasomal protein catabolic process, nervous system development, neuron differentiation, neuron projection development, regulation of Rho protein signal transduction, regulation of endocytosis, regulation of postsynaptic neurotransmitter receptor internalization, regulation of synaptic transmission, glutamatergic, regulation of synaptic vesicle endocytosis, signal transduction, synaptic vesicle endocytosis; MF: GTPase activator activity, actin binding, ionotropic glutamate receptor binding, phospholipid binding, protein binding; CC: actin cytoskeleton, axon, cell projection, cytoplasm, dendrite, dendritic spine, glutamatergic synapse, postsynapse, presynapse, synapse, terminal bouton
Pathways: CDC42 GTPase cycle, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOG GTPase cycle, RHOJ GTPase cycle, RHOQ GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q99J31
Entrez ID: 94190
|
Does Knockout of Nradd in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Nradd
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Nradd (neurotrophin receptor associated death domain)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, apoptotic process, signal transduction; MF: coreceptor activity, death receptor activity, nerve growth factor binding, neurotrophin p75 receptor binding, protein binding; CC: cell body membrane, cell leading edge, cell surface, lamellipodium, membrane, neuron projection membrane, nuclear envelope lumen, nucleus, plasma membrane, plasma membrane bounded cell projection
Pathways:
UniProt: Q8CJ26
Entrez ID: 67169
|
Does Knockout of Slc40a1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Slc40a1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Slc40a1 (solute carrier family 40 (iron-regulated transporter), member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endothelium development, establishment of localization in cell, intracellular iron ion homeostasis, iron ion export across plasma membrane, iron ion transmembrane transport, iron ion transport, lymphocyte homeostasis, monoatomic ion transport, multicellular organismal-level iron ion homeostasis, negative regulation of apoptotic process, positive regulation of transcription by RNA polymerase II, spleen development, spleen trabecula formation, transmembrane transport; MF: ferrous iron transmembrane transporter activity, identical protein binding, iron ion transmembrane transporter activity, metal ion binding, peptide hormone binding, protein binding; CC: basolateral plasma membrane, cytosol, membrane, nucleoplasm, plasma membrane, synaptic vesicle
Pathways: Ferroptosis - Mus musculus (mouse), Iron uptake and transport, Metal ion SLC transporters, Mineral absorption - Mus musculus (mouse), SLC-mediated transmembrane transport, Transport of small molecules
UniProt: Q9JHI9
Entrez ID: 53945
|
Does Knockout of Ifna16 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Ifna16
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ifna16 (interferon alpha 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation involved in immune response, T cell activation involved in immune response, adaptive immune response, defense response, defense response to virus, humoral immune response, natural killer cell activation involved in immune response, response to exogenous dsRNA, type I interferon-mediated signaling pathway; MF: cytokine activity, cytokine receptor binding, type I interferon receptor binding; CC: extracellular region, extracellular space
Pathways: Alcoholic liver disease - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Cytosolic DNA-sensing pathway - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Interferon Signaling, Interferon alpha/beta signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse), Regulation of IFNA/IFNB signaling, Toll-like receptor signaling pathway - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q810G1
Entrez ID: 230398
|
Does Knockout of Satb1 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Satb1
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Satb1 (special AT-rich sequence binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD4-positive, alpha-beta T cell differentiation, CD8-positive, alpha-beta T cell differentiation, T cell activation, activated T cell proliferation, chromatin organization, chromatin remodeling, epidermis development, negative regulation of transcription by RNA polymerase II, reflex, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, sequence-specific DNA binding; CC: PML body, chromatin, heterochromatin, nuclear body, nuclear lumen, nuclear matrix, nucleoplasm, nucleus
Pathways:
UniProt: Q60611
Entrez ID: 20230
|
Does Knockout of Prss44 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Prss44
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Prss44 (serine protease 44)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: germ cell development, proteolysis, spermatogenesis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: cytoplasm, extracellular space, membrane
Pathways:
UniProt: Q402U7
Entrez ID: 73336
|
Does Knockout of Il4 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Il4
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Il4 (interleukin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, B cell costimulation, T cell activation, T-helper 1 cell lineage commitment, T-helper 2 cell differentiation, autophagy, cell surface receptor signaling pathway via JAK-STAT, cholesterol metabolic process, defense response to protozoan, dendritic cell differentiation, extrinsic apoptotic signaling pathway in absence of ligand, immune response, innate immune response in mucosa, interleukin-4-mediated signaling pathway, leukocyte activation, macrophage activation, microglial cell activation, myeloid dendritic cell differentiation, negative regulation of DNA-templated transcription, negative regulation of T cell activation, negative regulation of T-helper 17 cell differentiation, negative regulation of acute inflammatory response, negative regulation of cellular response to transforming growth factor beta stimulus, negative regulation of chronic inflammatory response, negative regulation of complement-dependent cytotoxicity, negative regulation of endothelial cell apoptotic process, negative regulation of epithelial cell migration, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of inflammatory response, negative regulation of leukocyte activation, negative regulation of macrophage activation, negative regulation of nitric oxide biosynthetic process, negative regulation of osteoclast differentiation, negative regulation of transcription by RNA polymerase II, negative regulation of tumor necrosis factor production, negative regulation of white fat cell proliferation, neuroinflammatory response, positive regulation of ATP biosynthetic process, positive regulation of B cell activation, positive regulation of B cell chemotaxis, positive regulation of B cell proliferation, positive regulation of DNA-templated transcription, positive regulation of MHC class II biosynthetic process, positive regulation of T cell differentiation, positive regulation of T cell proliferation, positive regulation of T-helper 2 cell cytokine production, positive regulation of activated T cell proliferation, positive regulation of amyloid-beta clearance, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cellular respiration, positive regulation of chemokine production, positive regulation of cold-induced thermogenesis, positive regulation of defense response to virus by host, positive regulation of eosinophil chemotaxis, positive regulation of gene expression, positive regulation of immunoglobulin production, positive regulation of interleukin-10 production, positive regulation of interleukin-13 production, positive regulation of isotype switching to IgE isotypes, positive regulation of isotype switching to IgG isotypes, positive regulation of leukocyte chemotaxis, positive regulation of macroautophagy, positive regulation of mast cell degranulation, positive regulation of mononuclear cell migration, positive regulation of myoblast fusion, positive regulation of reactive oxygen species biosynthetic process, positive regulation of receptor-mediated endocytosis, positive regulation of transcription by RNA polymerase II, regulation of immune response, regulation of primary metabolic process, regulation of proton transport, response to nematode, response to selenium ion; MF: cytokine activity, cytokine receptor binding, growth factor activity, interleukin-4 receptor binding; CC: external side of plasma membrane, extracellular region, extracellular space
Pathways: Allograft rejection - Mus musculus (mouse), Asthma - Mus musculus (mouse), Autoimmune thyroid disease - Mus musculus (mouse), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Fc epsilon RI signaling pathway - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Interleukin-4 and Interleukin-13 signaling, Intestinal immune network for IgA production - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Signaling by Interleukins, T cell receptor signaling pathway - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse)
UniProt: P07750
Entrez ID: 16189
|
Does Knockout of Mettl22 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Mettl22
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mettl22 (methyltransferase 22, Kin17 lysine)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: heat shock protein binding, methyltransferase activity, protein methyltransferase activity, protein-lysine N-methyltransferase activity, transferase activity; CC: nucleolus, nucleoplasm, nucleus, protein-containing complex
Pathways: Metabolism of proteins, Post-translational protein modification, Protein methylation
UniProt: Q8R1C6
Entrez ID: 239706
|
Does Knockout of Slc4a4 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Slc4a4
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Slc4a4 (solute carrier family 4 (anion exchanger), member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bicarbonate transport, establishment of localization in cell, inorganic anion transport, monoatomic anion transmembrane transport, monoatomic anion transport, monoatomic ion transport, positive regulation of glycolytic process, regulation of intracellular pH, regulation of membrane potential, regulation of pH, sodium ion export across plasma membrane, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: identical protein binding, monoatomic anion transmembrane transporter activity, protein binding, sodium:bicarbonate symporter activity, solute:inorganic anion antiporter activity, symporter activity; CC: basolateral plasma membrane, cell surface, cytosol, membrane, plasma membrane
Pathways: Bicarbonate transporters, Bile secretion - Mus musculus (mouse), Pancreatic secretion - Mus musculus (mouse), Proximal tubule bicarbonate reclamation - Mus musculus (mouse), SLC-mediated transmembrane transport, SLC-mediated transport of inorganic anions, Transport of small molecules
UniProt: O88343
Entrez ID: 54403
|
Does Knockout of Trap1a in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Trap1a
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Trap1a (tumor rejection antigen P1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: P19473
Entrez ID: 22037
|
Does Knockout of Foxo6 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Foxo6
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Foxo6 (forkhead box O6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: memory, positive regulation of dendritic spine development, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding; CC: cytoplasm, nucleoplasm, nucleus
Pathways: AKT phosphorylates targets in the nucleus, FOXO-mediated transcription, FoxO signaling pathway - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Intracellular signaling by second messengers, PIP3 activates AKT signaling, RNA Polymerase II Transcription, Regulation of localization of FOXO transcription factors, Signal Transduction
UniProt: Q70KY4
Entrez ID: 329934
|
Does Knockout of Mrgprb2 in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Mrgprb2
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Mrgprb2 (MAS-related GPR, member B2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, mast cell activation, mast cell degranulation, positive regulation of chemokine production, positive regulation of cytokine production, positive regulation of cytokinesis, positive regulation of neutrophil migration, response to pain, signal transduction; MF: G protein-coupled receptor activity, mast cell secretagogue receptor activity, neuropeptide binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q3KNA1
Entrez ID: 243979
|
Does Knockout of Ddx42 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 2,170
|
Knockout
|
Ddx42
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ddx42 (DEAD box helicase 42)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: U2-type prespliceosome assembly, intracellular protein localization, regulation of apoptotic process; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: U2-type prespliceosome, cytoplasm, cytosol, nuclear speck, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q810A7
Entrez ID: 72047
|
Does Knockout of Sec14l4 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,170
|
Knockout
|
Sec14l4
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Sec14l4 (SEC14-like lipid binding 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: lipid binding, molecular_function
Pathways:
UniProt: Q8R0F9
Entrez ID: 103655
|
Does Knockout of Cops7a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 167
|
Knockout
|
Cops7a
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Cops7a (COP9 signalosome subunit 7A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COP9 signalosome assembly, protein deneddylation; CC: COP9 signalosome, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, Global Genome Nucleotide Excision Repair (GG-NER), Membrane Trafficking, Metabolism of proteins, Neddylation, Nucleotide Excision Repair, Post-translational protein modification, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Vesicle-mediated transport
UniProt: Q9CZ04
Entrez ID: 26894
|
Does Knockout of Gm14393 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Gm14393
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Gm14393 (predicted gene 14393)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways: Herpes simplex virus 1 infection - Mus musculus (mouse)
UniProt: A2ARV8, A2ARW5
Entrez ID: 664987
|
Does Knockout of Capn5 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Capn5
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Capn5 (calpain 5)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the calpain family of proteins. Unlike many members of the calpain gene family, this gene lacks a calmodulin-like domain, required for calcium binding. Mouse models for Huntington's disease displayed increased levels of the protein encoded by this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: proteolysis; MF: calcium-dependent cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity; CC: cell surface, cytoplasm, synapse
Pathways: Degradation of the extracellular matrix, Extracellular matrix organization
UniProt: O08688
Entrez ID: 12337
|
Does Knockout of Stk38l in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Stk38l
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Stk38l (serine/threonine kinase 38 like)
Type: protein-coding
Summary: Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in regulation of cellular component organization. Located in actin cytoskeleton and cytoplasm. Orthologous to human STK38L (serine/threonine kinase 38 like). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: intracellular signal transduction, negative regulation of autophagy, positive regulation of autophagy, postsynapse organization, protein phosphorylation, regulation of cellular component organization; MF: ATP binding, actin binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: actin cytoskeleton, cytoplasm, cytoskeleton, cytosol, glutamatergic synapse, membrane
Pathways:
UniProt: Q7TSE6
Entrez ID: 232533
|
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