prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Pcdhga6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Pcdhga6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pcdhga6 (protocadherin gamma subfamily A, 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, molecular_function; CC: membrane, plasma membrane
Pathways:
UniProt: Q91XY2
Entrez ID: 93714
|
Does Knockout of Rnf170 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Rnf170
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rnf170 (ring finger protein 170)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult walking behavior, biological_process, gene expression, innate immune response, proprioception, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein catabolic process, protein polyubiquitination, protein ubiquitination, response to activity, response to temperature stimulus, sensory perception of pain, toll-like receptor 3 signaling pathway, walking behavior; MF: metal ion binding, molecular_function, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: cellular_component, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q8CBG9
Entrez ID: 77733
|
Does Knockout of Oas1f in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Oas1f
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Oas1f (2'-5' oligoadenylate synthetase 1F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, cellular response to exogenous dsRNA, cellular response to interferon-alpha, cellular response to interferon-beta, defense response to bacterium, defense response to virus, glucose homeostasis, glucose metabolic process, immune system process, innate immune response, interleukin-27-mediated signaling pathway, negative regulation of IP-10 production, negative regulation of chemokine (C-X-C motif) ligand 2 production, negative regulation of type I interferon-mediated signaling pathway, negative regulation of viral genome replication, positive regulation of cellular respiration, positive regulation of interferon-beta production, positive regulation of monocyte chemotactic protein-1 production, positive regulation of tumor necrosis factor production, protein complex oligomerization, response to virus, surfactant homeostasis, toll-like receptor 3 signaling pathway, toll-like receptor 4 signaling pathway, type I interferon-mediated signaling pathway; MF: 2'-5'-oligoadenylate synthetase activity, RNA binding, double-stranded RNA binding, nucleotidyltransferase activity; CC: cytoplasm, cytosol, membrane, mitochondrion, nucleoplasm, nucleus, ribosome
Pathways:
UniProt: F7AC31, Q14AZ4
Entrez ID: 243262
|
Does Knockout of Krt16 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Krt16
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Krt16 (keratin 16)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The encoded protein is a cytokeratin and acts as an innate immune system effector, promoting the inflammatory response upon breach of the skin barrier. Defects in this gene are a cause of pachyonychia congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: establishment of skin barrier, hair cycle, immune system process, inflammatory response, innate immune response, intermediate filament cytoskeleton organization, intermediate filament organization, keratinization, keratinocyte differentiation, keratinocyte migration, morphogenesis of an epithelium, negative regulation of cell migration; MF: protein binding, structural constituent of cytoskeleton, structural constituent of skin epidermis, structural molecule activity; CC: cornified envelope, cytoskeleton, intermediate filament, keratin filament
Pathways: Developmental Biology, Estrogen signaling pathway - Mus musculus (mouse), Formation of the cornified envelope, Keratinization, Staphylococcus aureus infection - Mus musculus (mouse)
UniProt: Q9Z2K1
Entrez ID: 16666
|
Does Knockout of Srebf2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Srebf2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Srebf2 (sterol regulatory element binding factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SREBP signaling pathway, cellular response to low-density lipoprotein particle stimulus, cellular response to starvation, cholesterol homeostasis, cholesterol metabolic process, lipid metabolic process, negative regulation of amyloid-beta clearance, negative regulation of cholesterol efflux, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of cholesterol biosynthetic process, positive regulation of cholesterol storage, positive regulation of miRNA transcription, positive regulation of myelination, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of Notch signaling pathway, regulation of transcription by RNA polymerase II, response to hormone, steroid metabolic process; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, protein binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, SREBP-SCAP-Insig complex, cytoplasm, cytoplasmic vesicle, dendrite, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleoplasm, nucleus
Pathways: Cholesterol biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroids, Regulation of cholesterol biosynthesis by SREBP (SREBF)
UniProt: Q3U1N2
Entrez ID: 20788
|
Does Knockout of Nedd1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,268
|
Knockout
|
Nedd1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Nedd1 (neural precursor cell expressed, developmentally down-regulated gene 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, microtubule depolymerization, microtubule nucleation, microtubule polymerization or depolymerization, mitotic cell cycle, regulation of establishment of protein localization; CC: apical part of cell, centriole, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, fibrillar center, gamma-tubulin ring complex, nucleoplasm, pericentriolar material, spindle pole
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: P33215
Entrez ID: 17997
|
Does Knockout of Srpk3 in Microglial Cell Line causally result in phagocytosis?
| 0
| 1,587
|
Knockout
|
Srpk3
|
phagocytosis
|
Microglial Cell Line
|
Gene: Srpk3 (serine/arginine-rich protein specific kinase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, intracellular signal transduction, muscle organ development, muscle tissue development, regulation of mRNA processing, skeletal muscle tissue development, spliceosomal complex assembly; MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9Z0G2
Entrez ID: 56504
|
Does Knockout of Psmd8 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Psmd8
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Psmd8 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis; CC: nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, proteasome regulatory particle, lid subcomplex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9CX56
Entrez ID: 57296
|
Does Knockout of Lhx5 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Lhx5
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Lhx5 (LIM homeobox protein 5)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of DNA-templated transcription and spinal cord association neuron differentiation. Acts upstream of or within cerebellar Purkinje cell-granule cell precursor cell signaling; nervous system development; and regulation of neural precursor cell proliferation. Predicted to be active in nucleus. Is expressed in several structures, including future brain; limb; nervous system; sensory organ; and urinary system. Orthologous to human LHX5 (LIM homeobox 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell proliferation in forebrain, cell-cell signaling, cerebellar Purkinje cell differentiation, cerebellar Purkinje cell-granule cell precursor cell signaling, cerebellum development, forebrain neuron differentiation, hippocampus development, neuroblast proliferation, neuron differentiation, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of cerebellar granule cell precursor proliferation, regulation of neuroblast proliferation, regulation of transcription by RNA polymerase II, spinal cord association neuron differentiation; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways: Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse)
UniProt: P61375
Entrez ID: 16873
|
Does Knockout of Eva1c in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Eva1c
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Eva1c (eva-1 homolog C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: carbohydrate binding, heparin binding, molecular_function; CC: extracellular region, membrane, plasma membrane
Pathways:
UniProt: P58659
Entrez ID: 70967
|
Does Knockout of Klc3 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Klc3
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Klc3 (kinesin light chain 3)
Type: protein-coding
Summary: Enables kinesin binding activity and microtubule binding activity. Involved in sperm mitochondrial sheath assembly. Acts upstream of or within axo-dendritic transport. Located in several cellular components, including ciliary rootlet; mitochondrion; and motile cilium. Is expressed in deep cerebellar nucleus; retina; and vestibular nucleus. Orthologous to human KLC3 (kinesin light chain 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: axo-dendritic transport, cell differentiation, intraciliary transport, microtubule-based movement, sperm mitochondrial sheath assembly, spermatid development, spermatogenesis; MF: kinesin binding, microtubule binding, protein binding; CC: ciliary rootlet, cytoplasm, cytoskeleton, kinesin complex, microtubule, mitochondrion, motile cilium, neuron projection
Pathways: Adaptive Immune System, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Huntington disease - Mus musculus (mouse), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, MHC class II antigen presentation, Membrane Trafficking, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases activate KTN1, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport
UniProt: Q91W40
Entrez ID: 232943
|
Does Knockout of Bard1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Bard1
|
cell proliferation
|
Regulatory T cell
|
Gene: Bard1 (BRCA1 associated RING domain 1)
Type: protein-coding
Summary: Predicted to enable RNA binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including negative regulation of protein export from nucleus; protein K6-linked ubiquitination; and regulation of apoptotic process. Located in nucleus. Is expressed in central nervous system; genitourinary system; limb; and spleen. Used to study breast cancer. Human ortholog(s) of this gene implicated in breast cancer and ovarian cancer. Orthologous to human BARD1 (BRCA1 associated RING domain 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA repair, DNA strand resection involved in replication fork processing, cellular response to ionizing radiation, homologous recombination, mitotic G2/M transition checkpoint, negative regulation of apoptotic process, negative regulation of protein export from nucleus, positive regulation of apoptotic process, positive regulation of cell cycle, protein K6-linked ubiquitination, protein ubiquitination, regulation of DNA damage checkpoint, regulation of DNA repair, regulation of phosphorylation; MF: RNA binding, metal ion binding, protein heterodimerization activity, protein homodimerization activity, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: BRCA1-A complex, BRCA1-B complex, BRCA1-BARD1 complex, BRCA1-C complex, cytoplasm, cytoplasmic ribonucleoprotein granule, nuclear speck, nuclear ubiquitin ligase complex, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Deubiquitination, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Metabolism of proteins, Metalloprotease DUBs, Nonhomologous End-Joining (NHEJ), Post-translational protein modification, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Transcriptional Regulation by TP53, UCH proteinases
UniProt: O70445
Entrez ID: 12021
|
Does Knockout of Phactr3 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Phactr3
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Phactr3 (phosphatase and actin regulator 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: actin binding, protein phosphatase inhibitor activity; CC: nuclear matrix, nucleoplasm, nucleus
Pathways:
UniProt: Q8BYK5
Entrez ID: 74189
|
Does Knockout of Tardbp in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,261
|
Knockout
|
Tardbp
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tardbp (TAR DNA binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, 3'-UTR-mediated mRNA stabilization, RNA splicing, amyloid fibril formation, gene expression, host-mediated suppression of viral transcription, mRNA processing, negative regulation of gene expression, nuclear inner membrane organization, positive regulation of insulin secretion, positive regulation of protein import into nucleus, regulation of apoptotic process, regulation of cell cycle, regulation of circadian rhythm, regulation of gene expression, regulation of protein stability, response to endoplasmic reticulum stress, rhythmic process; MF: DNA binding, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, double-stranded DNA binding, identical protein binding, lipid binding, mRNA 3'-UTR binding, molecular condensate scaffold activity, nucleic acid binding, pre-mRNA intronic binding, protein binding; CC: chromatin, cytoplasm, cytoplasmic stress granule, interchromatin granule, mitochondrion, nuclear speck, nucleoplasm, nucleus, perichromatin fibrils
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q921F2
Entrez ID: 230908
|
Does Knockout of Slc35g2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Slc35g2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Slc35g2 (solute carrier family 35, member G2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, cytoplasmic vesicle, membrane, plasma membrane, synapse, synaptic vesicle membrane
Pathways:
UniProt: D3YVE8
Entrez ID: 245020
|
Does Knockout of Fez1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Fez1
|
phagocytosis
|
macrophage
|
Gene: Fez1 (fasciculation and elongation protein zeta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to growth factor stimulus, establishment of cell polarity, establishment of mitochondrion localization, hippocampus development, mitochondrion organization, negative regulation of autophagosome assembly, positive regulation of anterograde axonal transport of mitochondrion, positive regulation of neuron projection development; MF: gamma-tubulin binding, protein binding, protein kinase C binding; CC: Golgi apparatus, axon, cell projection, centrosome, cytoplasm, cytoskeleton, dendrite, growth cone, membrane, microtubule, neuronal cell body, plasma membrane
Pathways:
UniProt: Q8K0X8
Entrez ID: 235180
|
Does Knockout of Cox5b in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Cox5b
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Cox5b (cytochrome c oxidase subunit 5B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial electron transport, cytochrome c to oxygen, oxidative phosphorylation; CC: membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, myelin sheath, respiratory chain complex IV
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: A0A0A6YVR0, Q9D881, F7C106
Entrez ID: 12859
|
Does Knockout of Tdrkh in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Tdrkh
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Tdrkh (tudor and KH domain containing protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: P granule organization, cell differentiation, fertilization, male meiotic nuclear division, piRNA processing, regulatory ncRNA-mediated gene silencing, spermatogenesis; MF: RNA binding, nucleic acid binding, protein binding; CC: P granule, cytoplasm, cytosol, mitochondrion, pi-body, piP-body
Pathways:
UniProt: Q80VL1
Entrez ID: 72634
|
Does Knockout of Fbxw18 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Fbxw18
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Fbxw18 (F-box and WD-40 domain protein 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, cytoplasm
Pathways:
UniProt: Q3TSA9
Entrez ID: 546161
|
Does Knockout of Ccdc33 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Ccdc33
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ccdc33 (coiled-coil domain containing 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: peroxisome
Pathways:
UniProt: Q3ULW6
Entrez ID: 382077
|
Does Knockout of Zc3h8 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Zc3h8
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zc3h8 (zinc finger CCCH type containing 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell homeostasis, apoptotic process, negative regulation of DNA-templated transcription, negative regulation of T cell differentiation in thymus, negative regulation of transcription by RNA polymerase II, positive regulation of thymocyte apoptotic process, positive regulation of transcription by RNA polymerase III, response to antibiotic, snRNA transcription by RNA polymerase II, snRNA transcription by RNA polymerase III; MF: DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA binding, RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: Cajal body, euchromatin, histone locus body, nuclear body, nucleoplasm, nucleus, transcription elongation factor complex
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q9JJ48
Entrez ID: 57432
|
Does Knockout of Timm22 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 1
| 345
|
Knockout
|
Timm22
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Timm22 (translocase of inner mitochondrial membrane 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein insertion into mitochondrial inner membrane, protein transmembrane transport, protein transport; MF: mitochondrion targeting sequence binding, protein binding, protein transmembrane transporter activity, protein transporter activity; CC: TIM22 mitochondrial import inner membrane insertion complex, membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q9CQ85
Entrez ID: 56322
|
Does Knockout of Ppp1r3g in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Ppp1r3g
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ppp1r3g (protein phosphatase 1, regulatory subunit 3G)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glucose homeostasis, positive regulation of glycogen biosynthetic process, regulation of glycogen biosynthetic process; MF: glycogen binding, protein binding, protein phosphatase 1 binding, protein phosphatase binding; CC: cytoplasm, protein phosphatase type 1 complex
Pathways:
UniProt: Q9CW07
Entrez ID: 76487
|
Does Knockout of Dach2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Dach2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Dach2 (dachshund family transcription factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: development of primary female sexual characteristics, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding; CC: nucleus, transcription regulator complex
Pathways:
UniProt: Q925Q8
Entrez ID: 93837
|
Does Knockout of Prkag2 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Prkag2
|
cell cycle progression
|
breast epithelium
|
Gene: Prkag2 (protein kinase, AMP-activated, gamma 2 non-catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to glucose starvation, cellular response to nutrient levels, fatty acid biosynthetic process, fatty acid metabolic process, glycogen metabolic process, intracellular signal transduction, lipid metabolic process, positive regulation of gluconeogenesis, regulation of carbon utilization, regulation of fatty acid metabolic process, regulation of glycolytic process; MF: ADP binding, AMP binding, AMP-activated protein kinase activity, ATP binding, cAMP-dependent protein kinase inhibitor activity, cAMP-dependent protein kinase regulator activity, nucleotide binding, phosphorylase kinase regulator activity, protein kinase activator activity, protein kinase binding, protein kinase regulator activity; CC: cytoplasm, cytosol, nucleoplasm, nucleotide-activated protein kinase complex, nucleus
Pathways: AMPK inhibits chREBP transcriptional activation activity, AMPK signaling pathway - Mus musculus (mouse), AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), Adaptive Immune System, Adipocytokine signaling pathway - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Autophagy, Carnitine shuttle, Circadian rhythm - Mus musculus (mouse), Co-inhibition by PD-1, Energy dependent regulation of mTOR by LKB1-AMPK, Fatty acid metabolism, FoxO signaling pathway - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Glucagon signaling pathway - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Immune System, Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Integration of energy metabolism, Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MTOR signalling, Macroautophagy, Metabolism, Metabolism of lipids, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Signal Transduction, TP53 Regulates Metabolic Genes, Thermogenesis - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Transcriptional Regulation by TP53
UniProt: Q91WG5
Entrez ID: 108099
|
Does Knockout of Stra6 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Stra6
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Stra6 (stimulated by retinoic acid gene 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adrenal gland development, alveolar primary septum development, artery morphogenesis, blood vessel development, camera-type eye development, cognition, developmental growth, diaphragm development, digestive tract morphogenesis, ductus arteriosus closure, ear development, embryonic camera-type eye formation, embryonic digestive tract development, establishment of localization in cell, eyelid development in camera-type eye, face morphogenesis, feeding behavior, female genitalia development, head development, head morphogenesis, heart development, kidney development, learning, lung alveolus development, lung development, lung vasculature development, neuromuscular process, nose morphogenesis, paramesonephric duct development, positive regulation of behavior, positive regulation of receptor signaling pathway via JAK-STAT, pulmonary artery morphogenesis, pulmonary valve morphogenesis, retinol transport, smooth muscle tissue development, uterus morphogenesis, ventricular septum development, vitamin A import into cell, vocal learning; MF: protein binding, retinal binding, retinol binding, retinol transmembrane transporter activity, signaling receptor activity; CC: membrane, plasma membrane, protein-containing complex
Pathways: Sensory Perception, The canonical retinoid cycle in rods (twilight vision), Visual phototransduction
UniProt: O70491
Entrez ID: 20897
|
Does Knockout of Vmn1r160 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Vmn1r160
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Vmn1r160 (vomeronasal 1 receptor 160)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: E9Q346
Entrez ID: 620758
|
Does Knockout of Pbxip1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Pbxip1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Pbxip1 (pre B cell leukemia transcription factor interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: articular cartilage development, cell adhesion, cell migration, extracellular matrix disassembly, gene expression, gene expression involved in extracellular matrix organization, hemopoiesis, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, positive regulation of Wnt signaling pathway, positive regulation of chondrocyte proliferation, production of molecular mediator involved in inflammatory response, regulation of DNA-templated transcription; MF: DNA-binding transcription factor binding, protein binding, transcription coactivator activity, transcription coregulator activity, transcription corepressor activity; CC: chromatin, cytoplasm, cytoskeleton, cytosol, microtubule, nucleoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: Q3TVI8
Entrez ID: 229534
|
Does Knockout of Mlph in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Mlph
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Mlph (melanophilin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, melanocyte differentiation, melanosome localization, pigmentation, protein targeting; MF: actin binding, metal ion binding, microtubule plus-end binding, molecular adaptor activity, myosin V binding, myosin binding, protein binding, protein-macromolecule adaptor activity, small GTPase binding, zinc ion binding; CC: actin cytoskeleton, cortical actin cytoskeleton, cytoplasm, dendrite, melanosome, microtubule organizing center, perinuclear region of cytoplasm, stress fiber, unconventional myosin complex
Pathways: Developmental Biology, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Regulation of MITF-M-dependent genes involved in pigmentation
UniProt: Q91V27
Entrez ID: 171531
|
Does Knockout of Notch2 in Pancreatic Cell Line causally result in protein/peptide accumulation?
| 1
| 2,198
|
Knockout
|
Notch2
|
protein/peptide accumulation
|
Pancreatic Cell Line
|
Gene: Notch2 (notch 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, animal organ morphogenesis, apoptotic process, atrial septum morphogenesis, bone remodeling, camera-type eye morphogenesis, cell differentiation, cell fate determination, cellular response to tumor cell, cholangiocyte proliferation, ciliary body morphogenesis, defense response to bacterium, determination of left/right symmetry, developmental growth, embryonic limb morphogenesis, epithelial cell development, epithelial cell differentiation involved in kidney development, glomerular capillary formation, heart looping, hemopoiesis, hepatocyte proliferation, humoral immune response, in utero embryonic development, inflammatory response to antigenic stimulus, intracellular signal transduction, intrahepatic bile duct development, left/right axis specification, liver development, liver morphogenesis, marginal zone B cell differentiation, morphogenesis of an epithelial sheet, multicellular organism growth, myeloid dendritic cell differentiation, negative regulation of gene expression, negative regulation of macromolecule biosynthetic process, negative regulation of transcription by RNA polymerase II, nephron tubule development, placenta blood vessel development, placenta development, podocyte development, positive regulation of BMP signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of Ras protein signal transduction, positive regulation of apoptotic process, positive regulation of cell development, positive regulation of cell population proliferation, positive regulation of keratinocyte proliferation, positive regulation of miRNA transcription, positive regulation of osteoclast differentiation, positive regulation of smooth muscle cell differentiation, positive regulation of transcription by RNA polymerase II, proximal tubule development, pulmonary valve morphogenesis, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of developmental process, regulation of hemopoiesis, regulation of osteoclast development, regulation of transcription by RNA polymerase II, wound healing; MF: NF-kappaB binding, calcium ion binding, enzyme binding, protein binding, signaling receptor activity, transcription coactivator activity; CC: Golgi apparatus, cell surface, cilium, cytoplasm, cytosol, extracellular region, glutamatergic synapse, membrane, nucleoplasm, nucleus, plasma membrane, postsynaptic density membrane, receptor complex
Pathways: Breast cancer - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), Notch signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse)
UniProt: O35516
Entrez ID: 18129
|
Does Knockout of Chek2 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Chek2
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Chek2 (checkpoint kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA repair, G2/M transition of mitotic cell cycle, apoptotic process, autophagosome assembly, cell division, cellular response to bisphenol A, cellular response to gamma radiation, cellular response to stress, cellular response to xenobiotic stimulus, double-strand break repair, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, mitotic DNA damage checkpoint signaling, mitotic intra-S DNA damage checkpoint signaling, mitotic spindle assembly, negative regulation of DNA damage checkpoint, positive regulation of DNA-templated transcription, positive regulation of anoikis, positive regulation of autophagosome assembly, protein K63-linked ubiquitination, protein autophosphorylation, protein catabolic process, protein stabilization, regulation of DNA-templated transcription, regulation of autophagosome assembly, regulation of protein catabolic process, response to gamma radiation, response to glycoside, response to oxidative stress, response to starvation, signal transduction in response to DNA damage, thymocyte apoptotic process; MF: ATP binding, identical protein binding, kinase activity, metal ion binding, nucleotide binding, protein homodimerization activity, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity, ubiquitin protein ligase binding; CC: Golgi apparatus, PML body, chromosome, telomeric region, cytoplasm, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle Checkpoints, Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, G1/S DNA Damage Checkpoints, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of TP53 Activity, Regulation of TP53 Activity through Methylation, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Stabilization of p53, Transcriptional Regulation by TP53, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, p53 signaling pathway - Mus musculus (mouse), p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9Z265
Entrez ID: 50883
|
Does Knockout of Pigu in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,308
|
Knockout
|
Pigu
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Pigu (phosphatidylinositol glycan anchor biosynthesis, class U)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GPI anchor biosynthetic process, GPI anchored protein biosynthesis, attachment of GPI anchor to protein, regulation of receptor signaling pathway via JAK-STAT; MF: GPI anchor binding, GPI-anchor transamidase activity; CC: GPI-anchor transamidase complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Mus musculus (mouse)
UniProt: Q8K358
Entrez ID: 228812
|
Does Knockout of Pla2g4e in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Pla2g4e
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Pla2g4e (phospholipase A2, group IVE)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: N-acylphosphatidylethanolamine metabolic process, glycerophospholipid catabolic process, lipid catabolic process, lipid metabolic process, phospholipid catabolic process, positive regulation of endocytic recycling; MF: N-acyltransferase activity, calcium ion binding, calcium-dependent phospholipase A2 activity, calcium-dependent phospholipid binding, hydrolase activity, metal ion binding, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding, phosphatidylinositol-4,5-bisphosphate binding, phosphatidylinositol-4-phosphate binding, phosphatidylinositol-5-phosphate binding, phospholipase A2 activity, phospholipase activity, transferase activity; CC: cytoplasm, cytosol, early endosome membrane, endosome, lysosomal membrane, lysosome, membrane, plasma membrane
Pathways: Acyl chain remodelling of PC, Acyl chain remodelling of PE, Acyl chain remodelling of PI, Acyl chain remodelling of PS, Arachidonic acid metabolism - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Ether lipid metabolism - Mus musculus (mouse), Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Glutamatergic synapse - Mus musculus (mouse), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Hydrolysis of LPC, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Linoleic acid metabolism - Mus musculus (mouse), Long-term depression - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of lipids, Necroptosis - Mus musculus (mouse), Ovarian steroidogenesis - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Phospholipid metabolism, Platelet activation - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), VEGF signaling pathway - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), alpha-Linolenic acid metabolism - Mus musculus (mouse), phospholipases
UniProt: Q50L42
Entrez ID: 329502
|
Does Knockout of Tmem185b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Tmem185b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tmem185b (transmembrane protein 185B)
Type: protein-coding
Summary: Predicted to be located in membrane. Orthologous to human TMEM185B (transmembrane protein 185B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8R3R5
Entrez ID: 226351
|
Does Knockout of Zfhx3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Zfhx3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Zfhx3 (zinc finger homeobox 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: circadian regulation of gene expression, muscle organ development, negative regulation of myoblast differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of cell adhesion, positive regulation of myoblast differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of locomotor rhythm, regulation of neuron differentiation, regulation of transcription by RNA polymerase II, response to transforming growth factor beta; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, enzyme binding, metal ion binding, nucleic acid binding, transcription cis-regulatory region binding, zinc ion binding; CC: cytoplasm, mitochondrion, nuclear body, nucleoplasm, nucleus, transcription regulator complex
Pathways: Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse)
UniProt: A0A087WQ36, E9QMD3
Entrez ID: 11906
|
Does Knockout of Cyp27b1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Cyp27b1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cyp27b1 (cytochrome P450, family 27, subfamily b, polypeptide 1)
Type: protein-coding
Summary: Enables calcidiol 1-monooxygenase activity. Involved in calcitriol biosynthetic process from calciol; response to vitamin D; and vitamin D catabolic process. Acts upstream of or within calcium ion transport. Located in mitochondrion. Is expressed in several structures, including extraembryonic component; lower jaw molar; metanephros; and reproductive system. Used to study rickets. Human ortholog(s) of this gene implicated in hepatitis B; obesity; rickets; type 1 diabetes mellitus; and vitamin D-dependent rickets type 1A. Orthologous to human CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: G1 to G0 transition, bone mineralization, calcitriol biosynthetic process from calciol, calcium ion homeostasis, calcium ion transport, cellular response to vitamin D, decidualization, lipid metabolic process, negative regulation of bone trabecula formation, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of ossification, positive regulation of keratinocyte differentiation, positive regulation of parathyroid hormone secretion, positive regulation of vitamin D receptor signaling pathway, regulation of bone mineralization, response to cAMP, response to copper ion, response to estrogen, response to insulin, response to lipopolysaccharide, response to prostaglandin E, response to type II interferon, response to vitamin D, response to xenobiotic stimulus, vitamin D biosynthetic process, vitamin D catabolic process, vitamin D metabolic process; MF: calcidiol 1-monooxygenase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, secalciferol 1-monooxygenase activity; CC: cytoplasm, membrane, mitochondrial membrane, mitochondrion
Pathways: 1,25-dihydroxyvitamin D<sub>3</sub> biosynthesis, Biological oxidations, Cytochrome P450 - arranged by substrate type, Metabolism, Metabolism of lipids, Metabolism of steroids, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Phase I - Functionalization of compounds, Steroid biosynthesis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Vitamin D (calciferol) metabolism, Vitamins
UniProt: O35084
Entrez ID: 13115
|
Does Knockout of Cntnap5c in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Cntnap5c
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Cntnap5c (contactin associated protein-like 5C)
Type: protein-coding
Summary: Predicted to be involved in cell adhesion. Predicted to be located in cell junction and membrane. Is expressed in CA1 pyramidal cell layer; brain; central nervous system; and hippocampus CA3. Orthologous to human CNTNAP5 (contactin associated protein family member 5). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cell adhesion, retina homeostasis; CC: membrane, synapse
Pathways:
UniProt: Q0V8T7
Entrez ID: 620292
|
Does Knockout of Slc32a1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Slc32a1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Slc32a1 (solute carrier family 32 (GABA vesicular transporter), member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: beta-alanine transport, gamma-aminobutyric acid import, gamma-aminobutyric acid transport, glycine transport, hippocampus development, neurotransmitter loading into synaptic vesicle, neurotransmitter transport, proton transmembrane transport; MF: gamma-aminobutyric acid transmembrane transporter activity, gamma-aminobutyric acid:proton antiporter activity, glycine transmembrane transporter activity, glycine:proton antiporter activity; CC: GABA-ergic synapse, cell projection, cell surface, cell tip, cone cell pedicle, cytoplasmic vesicle, cytoplasmic vesicle membrane, dendrite, dendrite terminus, inhibitory synapse, membrane, neuron projection, neuron projection terminus, plasma membrane, presynapse, presynaptic active zone, synapse, synaptic vesicle, synaptic vesicle membrane
Pathways: GABA synthesis, release, reuptake and degradation, GABAergic synapse - Mus musculus (mouse), Morphine addiction - Mus musculus (mouse), Neuronal System, Neurotransmitter release cycle, Nicotine addiction - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), SLC-mediated transmembrane transport, SLC-mediated transport of neurotransmitters, Synaptic vesicle cycle - Mus musculus (mouse), Transmission across Chemical Synapses, Transport of small molecules
UniProt: O35633
Entrez ID: 22348
|
Does Knockout of Prr12 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Prr12
|
cell proliferation
|
Regulatory T cell
|
Gene: Prr12 (proline rich 12)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Predicted to be located in neuron projection; nucleus; and postsynaptic density. Is expressed in central nervous system and retina. Orthologous to human PRR12 (proline rich 12). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, intracellular protein localization; MF: DNA binding, molecular_function; CC: cellular_component, neuron projection, nucleus, postsynaptic density, synapse
Pathways:
UniProt: E9PYL2
Entrez ID: 233210
|
Does Knockout of Gbx1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Gbx1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Gbx1 (gastrulation brain homeobox 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult walking behavior, neuron fate commitment, proprioception, regulation of DNA-templated transcription, regulation of nervous system development, regulation of transcription by RNA polymerase II, sensory neuron axon guidance, spinal cord motor neuron differentiation; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding; CC: nucleus
Pathways:
UniProt: P82976
Entrez ID: 231044
|
Does Knockout of Pik3ca in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Pik3ca
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Pik3ca (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC2 signaling, actin cytoskeleton organization, adipose tissue development, angiogenesis, autosome genomic imprinting, cardiac muscle cell contraction, cell migration, cellular response to glucose stimulus, cellular response to hydrostatic pressure, cellular response to insulin stimulus, energy homeostasis, glucose metabolic process, insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, liver development, negative regulation of actin filament depolymerization, negative regulation of anoikis, negative regulation of fibroblast apoptotic process, negative regulation of gene expression, negative regulation of neuron apoptotic process, phagocytosis, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol-mediated signaling, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein localization to membrane, positive regulation of smooth muscle cell proliferation, regulation of actin filament organization, regulation of cellular respiration, regulation of gene expression, regulation of multicellular organism growth, relaxation of cardiac muscle, response to L-leucine, response to activity, response to butyrate, response to dexamethasone, response to hormone, response to muscle inactivity, response to muscle stretch, vascular endothelial growth factor signaling pathway; MF: 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding, insulin receptor substrate binding, kinase activity, nucleotide binding, protein binding, protein kinase activator activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, intercalated disc, lamellipodium, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex, class IA, phosphatidylinositol 3-kinase complex, class IB, plasma membrane
Pathways: 3-phosphoinositide biosynthesis, AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), AMPK signaling pathway - Mus musculus (mouse), Acute myeloid leukemia - Mus musculus (mouse), Adaptive Immune System, Aldosterone-regulated sodium reabsorption - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Axon guidance, Axon guidance - Mus musculus (mouse), B cell receptor signaling pathway - Mus musculus (mouse), Bacterial invasion of epithelial cells - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), CD28 dependent PI3K/Akt signaling, Carbohydrate digestion and absorption - Mus musculus (mouse), Cell surface interactions at the vascular wall, Cellular senescence - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Co-stimulation by CD28, Co-stimulation by ICOS, Colorectal cancer - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, DAP12 interactions, DAP12 signaling, Developmental Biology, Diabetic cardiomyopathy - Mus musculus (mouse), Downstream TCR signaling, Downstream signal transduction, Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, ESR-mediated signaling, Endometrial cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Estrogen signaling pathway - Mus musculus (mouse), Extra-nuclear estrogen signaling, FLT3 Signaling, Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc epsilon receptor (FCERI) signaling, Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), G alpha (q) signalling events, GAB1 signalosome, GPCR downstream signalling, GPVI-mediated activation cascade, Gastric cancer - Mus musculus (mouse), Glioma - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hemostasis, Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Innate Immune System, Inositol phosphate metabolism - Mus musculus (mouse), Insulin receptor signalling cascade, Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Interleukin receptor SHC signaling, Interleukin-2 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Intracellular signaling by second messengers, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, MET activates PI3K/AKT signaling, Measles - Mus musculus (mouse), Melanoma - Mus musculus (mouse), Metabolism, Metabolism of lipids, MicroRNAs in cancer - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Negative regulation of the PI3K/AKT network, Nervous system development, Neurotrophin signaling pathway - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Non-small cell lung cancer - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI Metabolism, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI3K events in ERBB2 signaling, PI3K events in ERBB4 signaling, PI3K-Akt signaling pathway - Mus musculus (mouse), PI3K/AKT activation, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP metabolism, PIP3 activates AKT signaling, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Phospholipid metabolism, Platelet activation - Mus musculus (mouse), Platelet activation, signaling and aggregation, Prion disease - Mus musculus (mouse), Progesterone-mediated oocyte maturation - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RAF/MAP kinase cascade, RET signaling, RHO GTPase cycle, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of T cell activation by CD28 family, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of lipolysis in adipocytes - Mus musculus (mouse), Regulation of signaling by CBL, Relaxin signaling pathway - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), Role of LAT2/NTAL/LAB on calcium mobilization, Role of phospholipids in phagocytosis, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by ALK, Signaling by EGFR, Signaling by ERBB2, Signaling by ERBB4, Signaling by Erythropoietin, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by GPCR, Signaling by Insulin receptor, Signaling by Interleukins, Signaling by LTK, Signaling by MET, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Nuclear Receptors, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by SCF-KIT, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling by VEGF, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), Synthesis of PIPs at the plasma membrane, T cell receptor signaling pathway - Mus musculus (mouse), TCR signaling, TNF signaling pathway - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Tie2 Signaling, Toll-like receptor signaling pathway - Mus musculus (mouse), Type II diabetes mellitus - Mus musculus (mouse), VEGF signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, Viral carcinogenesis - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: P42337
Entrez ID: 18706
|
Does Knockout of Nudt1 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,549
|
Knockout
|
Nudt1
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Nudt1 (nudix hydrolase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA protection, purine nucleoside catabolic process; MF: 2-hydroxy-ATP hydrolase activity, 2-hydroxy-dATP hydrolase activity, 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity, 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity, 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity, ATP diphosphatase activity, N6-methyl-(d)ATP hydrolase activity, O6-methyl-dGTP hydrolase activity, RNA binding, dATP diphosphatase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, metal ion binding, snoRNA binding; CC: acrosomal vesicle, cytoplasm, cytoplasmic vesicle, cytosol, extracellular space, membrane, mitochondrial matrix, mitochondrion, nuclear membrane, nucleus
Pathways: Metabolism, Metabolism of nucleotides, Nucleotide catabolism, Phosphate bond hydrolysis by NUDT proteins, Purine catabolism
UniProt: P53368
Entrez ID: 17766
|
Does Knockout of Pdzd11 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Pdzd11
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Pdzd11 (PDZ domain containing 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biotin metabolic process, neurotransmitter secretion, pore complex assembly, regulation of synaptic assembly at neuromuscular junction, synaptic vesicle transport; MF: enzyme activator activity, protein binding, protein-macromolecule adaptor activity, transporter activator activity; CC: adherens junction, anchoring junction, basolateral plasma membrane, cell-cell junction, cytoplasm, cytosol, membrane, plasma membrane, pore complex, presynapse
Pathways: Antimicrobial peptides, Biotin transport and metabolism, Immune System, Innate Immune System, Ion channel transport, Ion influx/efflux at host-pathogen interface, Ion transport by P-type ATPases, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, SLC-mediated transmembrane transport, Transport of small molecules, Transport of vitamins, nucleosides, and related molecules, Vitamin B5 (pantothenate) metabolism
UniProt: Q9CZG9
Entrez ID: 72621
|
Does Knockout of Dynlt1b in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Dynlt1b
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dynlt1b (dynein light chain Tctex-type 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon development, cardiac muscle cell apoptotic process, cell division, dendrite development, establishment of mitotic spindle orientation, intracellular transport of viral protein in host cell, microtubule-based movement, negative regulation of ERK1 and ERK2 cascade, negative regulation of mitochondrial membrane permeability, negative regulation of neurogenesis, nervous system development, neuron projection morphogenesis, positive regulation of Rac protein signal transduction, positive regulation of neuron projection development, regulation of G protein-coupled receptor signaling pathway, regulation of cytoskeleton organization; MF: G-protein beta-subunit binding, GTP-dependent protein binding, dynein intermediate chain binding, identical protein binding, protein binding, transmembrane transporter binding; CC: Golgi apparatus, axonal growth cone, cytoplasm, cytoplasmic dynein complex, cytoskeleton, dynein complex, growth cone, lamellipodium, microtubule, neuronal cell body, photoreceptor inner segment, spindle
Pathways: Immune System, Innate Immune System, Neutrophil degranulation, Salmonella infection - Mus musculus (mouse)
UniProt: P51807
Entrez ID: 21648
|
Does Knockout of Pde6h in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Pde6h
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Pde6h (phosphodiesterase 6H, cGMP-specific, cone, gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of G protein-coupled receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of epidermal growth factor receptor signaling pathway, visual perception; MF: 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, cGMP binding, hydrolase activity
Pathways: Purine metabolism - Mus musculus (mouse)
UniProt: P61249
Entrez ID: 78600
|
Does Knockout of Nat1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Nat1
|
cell cycle progression
|
breast epithelium
|
Gene: Nat1 (N-acetyl transferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: N-hydroxyarylamine O-acetyltransferase activity, acetyltransferase activity, acyltransferase activity, arylamine N-acetyltransferase activity, transferase activity
Pathways: Acetylation, Biological oxidations, Caffeine metabolism - Mus musculus (mouse), Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Drug ADME, Drug metabolism - other enzymes - Mus musculus (mouse), Metabolism, Paracetamol ADME, Phase II - Conjugation of compounds
UniProt: P50294
Entrez ID: 17960
|
Does Knockout of Pcdh18 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Pcdh18
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pcdh18 (protocadherin 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, protein binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q8VHR0
Entrez ID: 73173
|
Does Knockout of Cryba2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,663
|
Knockout
|
Cryba2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cryba2 (crystallin, beta A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: eye development, lens development in camera-type eye, visual perception; MF: identical protein binding, structural constituent of eye lens
Pathways:
UniProt: Q9JJV1
Entrez ID: 12958
|
Does Knockout of Map2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Map2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Map2 (microtubule-associated protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axonogenesis, dendrite development, establishment of cell polarity, microtubule bundle formation, microtubule cytoskeleton organization, negative regulation of axon extension, negative regulation of microtubule depolymerization, negative regulation of microtubule polymerization, neuron projection development, positive regulation of anterograde dense core granule transport, positive regulation of anterograde synaptic vesicle transport, regulation of neurofibrillary tangle assembly, regulation of organelle transport along microtubule, regulation of protein localization; MF: SH2 domain binding, actin binding, calmodulin binding, cytoskeletal regulatory protein binding, dystroglycan binding, microtubule binding, protein binding, protein kinase binding, tubulin binding; CC: CA3 pyramidal cell dendrite, actin cytoskeleton, apical dendrite, apical distal dendrite, axon hillock, axon initial segment, basal dendrite, cell body, cell projection, cilium, cytoplasm, cytoskeleton, cytosol, dendrite, dendrite cytoplasm, dendritic branch, dendritic filopodium, dendritic growth cone, dendritic shaft, distal dendrite, glutamatergic synapse, microtubule, microtubule associated complex, microtubule cytoskeleton, neuron projection, neuronal cell body, nuclear periphery, plasma membrane, postsynapse, postsynaptic density, primary dendrite, protein-containing complex, proximal dendrite, proximal neuron projection, ruffle membrane
Pathways:
UniProt: P20357
Entrez ID: 17756
|
Does Knockout of 4931400O07Rik in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,268
|
Knockout
|
4931400O07Rik
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: 4931400O07Rik (RIKEN cDNA 4931400O07 gene)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 70936
|
Does Knockout of Rab33a in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Rab33a
|
cell cycle progression
|
breast epithelium
|
Gene: Rab33a (RAB33A, member RAS oncogene family)
Type: protein-coding
Summary: This gene encodes a member of the Ras-related small GTPases, which regulate membrane trafficking in organelles and transport vesicles. This protein has been reported to be expressed in lymphocytes and in regions of the mouse brain, specifically the cortex, hippocampus and also the olfactory bulb. The ortholog of this protein in rat has been characterized and may participate in anterograde trafficking of synaptophysin-positive vesicles to the plasma membrane. [provided by RefSeq, Jun 2013].
Gene Ontology: BP: Rab protein signal transduction, antigen processing and presentation, autophagosome assembly; MF: G protein activity, GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding; CC: Golgi apparatus, endosome, membrane, plasma membrane
Pathways: Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, RAB geranylgeranylation, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: P97950
Entrez ID: 19337
|
Does Knockout of Ulk1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Ulk1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ulk1 (unc-51 like kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, autophagosome assembly, autophagy, axon extension, axon guidance, axonogenesis, cellular response to amino acid starvation, cellular response to nutrient levels, cellular response to stress, cerebellar granule cell differentiation, collateral sprouting, establishment of localization in cell, intracellular protein localization, macroautophagy, mitophagy, negative regulation of cell population proliferation, negative regulation of collateral sprouting, negative regulation of protein-containing complex assembly, neuron migration, neuron projection development, neuron projection regeneration, peptidyl-serine phosphorylation, piecemeal microautophagy of the nucleus, positive regulation of autophagosome assembly, positive regulation of autophagy, protein-containing complex assembly, radial glia guided migration of cerebellar granule cell, receptor internalization, regulation of autophagy, regulation of gene expression, regulation of macroautophagy, regulation of neurotrophin TRK receptor signaling pathway, response to mitochondrial depolarisation, response to starvation, reticulophagy, signal transduction, somatic sensory system development, ubiquitin-dependent protein catabolic process; MF: ATP binding, GTPase binding, Hsp90 protein binding, identical protein binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, small GTPase binding, transferase activity; CC: Atg1/ULK1 kinase complex, autophagosome, autophagosome membrane, axon, cytoplasm, cytoplasmic vesicle membrane, cytosol, membrane, neuron projection, neuronal cell body, omegasome membrane, phagophore assembly site, phagophore assembly site membrane
Pathways: AMPK signaling pathway - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Autophagy, Autophagy - animal - Mus musculus (mouse), Death Receptor Signaling, Huntington disease - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Macroautophagy, Membrane Trafficking, Mitophagy, Mitophagy - animal - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Receptor Mediated Mitophagy, Regulation of TNFR1 signaling, Selective autophagy, Signal Transduction, Spinocerebellar ataxia - Mus musculus (mouse), TBC/RABGAPs, TNF signaling, Vesicle-mediated transport, mTOR signaling pathway - Mus musculus (mouse)
UniProt: O70405
Entrez ID: 22241
|
Does Knockout of Eif3i in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Eif3i
|
response to bacteria
|
macrophage
|
Gene: Eif3i (eukaryotic translation initiation factor 3, subunit I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, translation, translational initiation; MF: RNA binding, protein binding, translation initiation factor activity; CC: cytoplasm, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: Q9QZD9
Entrez ID: 54709
|
Does Knockout of Siglecf in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Siglecf
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Siglecf (sialic acid binding Ig-like lectin F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, regulation of endocytosis; MF: carbohydrate binding, monosaccharide binding, sialic acid binding; CC: cytoplasm, lysosome, membrane, plasma membrane
Pathways: Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
UniProt: Q920G3
Entrez ID: 233186
|
Does Knockout of Pfdn1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Pfdn1
|
cell proliferation
|
Regulatory T cell
|
Gene: Pfdn1 (prefoldin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, actin cytoskeleton organization, cerebellum development, negative regulation of amyloid fibril formation, protein folding, telencephalon development; MF: amyloid-beta binding, protein binding, protein folding chaperone, unfolded protein binding; CC: centrosome, cytoplasm, prefoldin complex
Pathways:
UniProt: A0A494BBK3, Q9CQF7, A0A494BAH5
Entrez ID: 67199
|
Does Knockout of Nox1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Nox1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Nox1 (NADPH oxidase 1)
Type: protein-coding
Summary: This gene encodes a subunit of the NADPH oxidase enzyme, which is a membrane-bound, multisubunit protein. This complex catalyzes the transfer of electrons from NADPH to molecular oxygen to produce superoxide or hydrogen peroxide and may have a role in antimicrobial killing and cell signaling. This protein binds other subunits in order to produce superoxide. In mouse, deficiency of this enzyme may be associated with changes in blood pressure. [provided by RefSeq, Jun 2013].
Gene Ontology: BP: angiogenesis, cell chemotaxis, cell migration, cellular response to hyperoxia, defense response, extracellular matrix organization, glutathione metabolic process, hydrogen peroxide metabolic process, negative regulation of neuron maturation, oxygen metabolic process, positive regulation of JNK cascade, positive regulation of MAPK cascade, positive regulation of cell population proliferation, positive regulation of inclusion body assembly, positive regulation of integrin biosynthetic process, positive regulation of neuron apoptotic process, positive regulation of neuron projection development, positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, positive regulation of reactive oxygen species metabolic process, positive regulation of smooth muscle cell proliferation, positive regulation of superoxide anion generation, positive regulation of vascular associated smooth muscle cell migration, positive regulation of vascular associated smooth muscle cell proliferation, positive regulation of vascular endothelial growth factor production, regulation of systemic arterial blood pressure by renin-angiotensin, response to reactive oxygen species, superoxide anion generation, superoxide metabolic process; MF: NAD(P)H oxidase H2O2-forming activity, metal ion binding, oxidoreductase activity, small GTPase binding, superoxide-generating NAD(P)H oxidase activity, superoxide-generating NADPH oxidase activity; CC: NADPH oxidase complex, anchoring junction, cell projection, cytoplasm, early endosome, endosome, membrane, plasma membrane
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), RAC1 GTPase cycle, RAC3 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate NADPH Oxidases, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8CIZ9
Entrez ID: 237038
|
Does Knockout of Galk1 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Galk1
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Galk1 (galactokinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate phosphorylation, galactitol metabolic process, galactose catabolic process via UDP-galactose, Leloir pathway, galactose metabolic process, glycolytic process from galactose; MF: ATP binding, galactokinase activity, galactose binding, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, protein binding, transferase activity; CC: cytoplasm, cytosol
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Galactose catabolism, Galactose metabolism - Mus musculus (mouse), Leloir pathway, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose), colanic acid building blocks biosynthesis, galactose degradation I (Leloir pathway)
UniProt: Q9R0N0
Entrez ID: 14635
|
Does Knockout of Dysf in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Dysf
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Dysf (dysferlin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T-tubule organization, angiogenesis, cellular response to osmotic stress, fat cell differentiation, glycerol metabolic process, lipid storage, macrophage activation involved in immune response, membrane fusion, monocyte activation involved in immune response, muscle cell development, negative regulation of gene expression, negative regulation of phagocytosis, negative regulation of protein catabolic process, negative regulation of protein polyubiquitination, plasma membrane repair, positive regulation of cell adhesion, positive regulation of endothelial cell proliferation, positive regulation of neutrophil chemotaxis, regulation of calcium ion import, skeletal muscle tissue regeneration, vesicle fusion; MF: alpha-tubulin binding, calcium ion binding, calcium-dependent phospholipid binding, lipid binding, metal ion binding, microtubule binding, phospholipid binding, protein binding; CC: Golgi apparatus, T-tubule, centriolar satellite, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, early endosome, endocytic vesicle, endomembrane system, endosome, lamellipodium, late endosome, late endosome membrane, membrane, membrane microdomain, microtubule, microtubule cytoskeleton, nucleus, plasma membrane, sarcolemma
Pathways:
UniProt: Q9ESD7
Entrez ID: 26903
|
Does Knockout of Tnrc6b in Pancreatic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,196
|
Knockout
|
Tnrc6b
|
protein/peptide accumulation
|
Pancreatic Cell Line
|
Gene: Tnrc6b (trinucleotide repeat containing 6b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: miRNA-mediated gene silencing by inhibition of translation, miRNA-mediated post-transcriptional gene silencing, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, regulation of translation, regulatory ncRNA-mediated gene silencing; MF: RNA binding, nucleic acid binding; CC: P-body, cytoplasm, cytosol, nucleoplasm
Pathways: Gene Silencing by RNA, Gene expression (Transcription), Post-transcriptional silencing by small RNAs
UniProt: Q8BKI2
Entrez ID: 213988
|
Does Knockout of Eng in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Eng
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Eng (endoglin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, artery morphogenesis, atrial cardiac muscle tissue morphogenesis, atrioventricular canal morphogenesis, branching involved in blood vessel morphogenesis, cardiac atrium morphogenesis, cardiac jelly development, cardiac ventricle morphogenesis, cell adhesion, cell chemotaxis, cell migration, cell migration involved in endocardial cushion formation, cell motility, central nervous system vasculogenesis, detection of hypoxia, dorsal aorta morphogenesis, endocardial cushion morphogenesis, endocardial cushion to mesenchymal transition, epithelial to mesenchymal transition involved in endocardial cushion formation, extracellular matrix constituent secretion, extracellular matrix disassembly, heart development, heart looping, negative regulation of SMAD protein signal transduction, negative regulation of cell migration, negative regulation of endothelial cell proliferation, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, outflow tract septum morphogenesis, positive regulation of BMP signaling pathway, positive regulation of SMAD protein signal transduction, positive regulation of angiogenesis, positive regulation of collagen biosynthetic process, positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation, positive regulation of gene expression, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of systemic arterial blood pressure, positive regulation of transcription by RNA polymerase II, positive regulation of vascular associated smooth muscle cell differentiation, regulation of DNA-templated transcription, regulation of cardiac muscle cell apoptotic process, regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis, regulation of cell proliferation involved in heart morphogenesis, regulation of transforming growth factor beta receptor signaling pathway, response to hypoxia, smooth muscle tissue development, sprouting angiogenesis, transforming growth factor beta receptor signaling pathway, vascular associated smooth muscle cell development, vasculogenesis, venous blood vessel morphogenesis, ventricular trabecula myocardium morphogenesis, wound healing; MF: BMP binding, coreceptor activity, galactose binding, glycosaminoglycan binding, identical protein binding, protein binding, protein homodimerization activity, signaling receptor activator activity, transforming growth factor beta binding, type I transforming growth factor beta receptor binding, type II transforming growth factor beta receptor binding; CC: cell surface, endothelial microparticle, external side of plasma membrane, extracellular space, membrane, nuclear body, plasma membrane, receptor complex
Pathways:
UniProt: Q63961
Entrez ID: 13805
|
Does Knockout of Aktip in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Aktip
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Aktip (AKT interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, early endosome to late endosome transport, endosome organization, endosome to lysosome transport, lysosome organization, postreplication repair, protein K63-linked ubiquitination, protein localization to perinuclear region of cytoplasm, protein transport; CC: FHF complex, HOPS complex, cytoplasm, membrane, nucleus, plasma membrane
Pathways:
UniProt: Q64362
Entrez ID: 14339
|
Does Knockout of Cbx2 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,181
|
Knockout
|
Cbx2
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Cbx2 (chromobox 2)
Type: protein-coding
Summary: This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in results in male-to-female gonadal sex reversal. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: chromatin organization, development of primary sexual characteristics, negative regulation of transcription by RNA polymerase II; MF: DNA binding, chromatin binding, histone H3K9me2/3 reader activity, protein binding; CC: PRC1 complex, PcG protein complex, chromosome, euchromatin, heterochromatin, nuclear speck, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of RNA binding proteins, SUMOylation of chromatin organization proteins, SUMOylation of transcription cofactors, Transcriptional regulation by RUNX1
UniProt: P30658
Entrez ID: 12416
|
Does Knockout of Hes6 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Hes6
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Hes6 (hairy and enhancer of split 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior/posterior pattern specification, cell differentiation, negative regulation of transcription by RNA polymerase II, nervous system development, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of neurogenesis, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, protein dimerization activity, protein heterodimerization activity, protein homodimerization activity, sequence-specific double-stranded DNA binding, transcription regulator inhibitor activity; CC: nucleus, transcription regulator complex
Pathways: Human papillomavirus infection - Mus musculus (mouse)
UniProt: Q9JHE6
Entrez ID: 55927
|
Does Knockout of Pcp4l1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,680
|
Knockout
|
Pcp4l1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pcp4l1 (Purkinje cell protein 4-like 1)
Type: protein-coding
Summary: Is expressed in several structures, including alimentary system; brain; cardiovascular system; future midbrain; and genitourinary system. Orthologous to human PCP4L1 (Purkinje cell protein 4 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q6W8Q3
Entrez ID: 66425
|
Does Knockout of Tecpr1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Tecpr1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Tecpr1 (tectonin beta-propeller repeat containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome maturation, autophagy, macroautophagy, regulation of autophagosome maturation; MF: lipid binding, phosphatidylinositol-3-phosphate binding; CC: autophagosome membrane, bounding membrane of organelle, cytoplasm, cytoplasmic vesicle, lysosomal membrane, lysosome, membrane, nucleoplasm, protein-containing complex
Pathways:
UniProt: Q80VP0
Entrez ID: 70381
|
Does Knockout of Nipsnap3b in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Nipsnap3b
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Nipsnap3b (nipsnap homolog 3B)
Type: protein-coding
Summary: Predicted to be involved in mitophagy. Located in mitochondrion. Is expressed in cortical plate and genitourinary system. Orthologous to several human genes including NIPSNAP3A (nipsnap homolog 3A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: biological_process, mitophagy; CC: cytoplasm, cytosol, mitochondrion
Pathways:
UniProt: Q9CQE1
Entrez ID: 66536
|
Does Knockout of Nap1l2 in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Nap1l2
|
response to virus
|
Microglial Cell Line
|
Gene: Nap1l2 (nucleosome assembly protein 1-like 2)
Type: protein-coding
Summary: Enables chromatin binding activity; histone acetyltransferase regulator activity; and histone binding activity. Acts upstream of or within positive regulation of neuron differentiation and regulation of stem cell division. Predicted to be active in chromatin and nucleus. Is expressed in nervous system. Orthologous to human NAP1L2 (nucleosome assembly protein 1 like 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: nucleosome assembly, positive regulation of neuron differentiation, regulation of stem cell division; MF: chromatin binding, histone acetyltransferase regulator activity, histone binding, protein binding; CC: chromatin, nucleus
Pathways:
UniProt: P51860
Entrez ID: 17954
|
Does Knockout of Cul4a in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Cul4a
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cul4a (cullin 4A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, T cell activation, base-excision repair, AP site formation via deaminated base removal, cellular response to UV, developmental process, hemopoiesis, in utero embryonic development, miRNA-mediated gene silencing by mRNA destabilization, negative regulation of granulocyte differentiation, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of cell population proliferation, positive regulation of protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination, regulation of DNA damage checkpoint, regulation of nucleotide-excision repair, regulation of protein metabolic process, rhythmic process, ribosome biogenesis, somatic stem cell population maintenance, spermatogenesis, type I interferon-mediated signaling pathway, ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process via the C-end degron rule pathway; MF: protein binding, ubiquitin ligase complex scaffold activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding; CC: Cul4-RING E3 ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, cullin-RING ubiquitin ligase complex, cytoplasm, nucleus
Pathways: DNA Damage Bypass, DNA Damage Recognition in GG-NER, DNA Repair, Dual Incision in GG-NER, Dual incision in TC-NER, Formation of Incision Complex in GG-NER, Formation of TC-NER Pre-Incision Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Metabolism of proteins, Neddylation, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), Post-translational protein modification, Recognition of DNA damage by PCNA-containing replication complex, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q3TCH7
Entrez ID: 99375
|
Does Knockout of Foxr1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Foxr1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Foxr1 (forkhead box R1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: cytoplasm, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: Q3UTB7
Entrez ID: 382074
|
Does Knockout of Klc3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Klc3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Klc3 (kinesin light chain 3)
Type: protein-coding
Summary: Enables kinesin binding activity and microtubule binding activity. Involved in sperm mitochondrial sheath assembly. Acts upstream of or within axo-dendritic transport. Located in several cellular components, including ciliary rootlet; mitochondrion; and motile cilium. Is expressed in deep cerebellar nucleus; retina; and vestibular nucleus. Orthologous to human KLC3 (kinesin light chain 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: axo-dendritic transport, cell differentiation, intraciliary transport, microtubule-based movement, sperm mitochondrial sheath assembly, spermatid development, spermatogenesis; MF: kinesin binding, microtubule binding, protein binding; CC: ciliary rootlet, cytoplasm, cytoskeleton, kinesin complex, microtubule, mitochondrion, motile cilium, neuron projection
Pathways: Adaptive Immune System, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Huntington disease - Mus musculus (mouse), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, MHC class II antigen presentation, Membrane Trafficking, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases activate KTN1, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport
UniProt: Q91W40
Entrez ID: 232943
|
Does Knockout of Ipo7 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Ipo7
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Ipo7 (importin 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: innate immune response, intracellular protein transport, negative regulation of osteoblast differentiation, nucleocytoplasmic transport, positive regulation of odontoblast differentiation, positive regulation of protein localization to nucleus, protein import into nucleus, protein transport; MF: SMAD binding, histone binding, protein binding, small GTPase binding; CC: cytoplasm, cytosol, nuclear envelope, nucleoplasm, nucleus
Pathways: Nucleocytoplasmic transport - Mus musculus (mouse)
UniProt: Q9EPL8
Entrez ID: 233726
|
Does Knockout of 2700097O09Rik in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
2700097O09Rik
|
response to virus
|
Microglial Cell Line
|
Gene: 2700097O09Rik (RIKEN cDNA 2700097O09 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9CZH1, Q6PGK3
Entrez ID: 72658
|
Does Knockout of Rgr in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Rgr
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Rgr (retinal G protein coupled receptor)
Type: protein-coding
Summary: The gene is a member of the opsin family of G-protein coupled receptors. The encoded protein is expressed in the retina, and acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Disruption of a similar gene in human is associated with autosomal recessive (arRP) and autosomal dominant retinitis pigmentosa (adRP). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cellular response to light stimulus, detection of visible light, phototransduction, signal transduction, visual perception; MF: G protein-coupled photoreceptor activity, G protein-coupled receptor activity, photoreceptor activity; CC: membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Opsins, Signal Transduction, Signaling by GPCR
UniProt: Q9Z2B3
Entrez ID: 57811
|
Does Knockout of Gm10382 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Gm10382
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gm10382 (predicted gene 10382)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 639281
|
Does Knockout of Acmsd in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Acmsd
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Acmsd (amino carboxymuconate semialdehyde decarboxylase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-tryptophan catabolic process, negative regulation of quinolinate biosynthetic process, quinolinate metabolic process, secondary metabolic process; MF: aminocarboxymuconate-semialdehyde decarboxylase activity, carboxy-lyase activity, hydrolase activity, lyase activity, metal ion binding, zinc ion binding; CC: cytoplasm, cytosol
Pathways: 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA, Tryptophan metabolism - Mus musculus (mouse), tryptophan degradation III (eukaryotic)
UniProt: Q8R519
Entrez ID: 266645
|
Does Knockout of Il1rn in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Il1rn
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Il1rn (interleukin 1 receptor antagonist)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acute-phase response, fever generation, immune response, inflammatory response, insulin secretion, lipid metabolic process, memory, negative regulation of apoptotic process, negative regulation of cell migration, negative regulation of glutamate secretion, negative regulation of heterotypic cell-cell adhesion, negative regulation of interleukin-1-mediated signaling pathway, negative regulation of membrane potential, response to glucocorticoid, signal transduction; MF: cytokine activity, interleukin-1 receptor antagonist activity, interleukin-1 receptor binding, interleukin-1 type I receptor antagonist activity, interleukin-1 type II receptor antagonist activity, interleukin-1, type I receptor binding, interleukin-1, type II receptor binding; CC: centrosome, cytoplasm, cytosol, extracellular region, extracellular space, nucleoplasm, vesicle
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Signaling by Interleukins
UniProt: P25085
Entrez ID: 16181
|
Does Knockout of Mroh1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Mroh1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Mroh1 (maestro heat-like repeat family member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, lysosome fission; MF: membrane destabilizing activity, molecular_function; CC: cytoplasm, lysosomal membrane, lysosome, membrane
Pathways:
UniProt: E0CZ22
Entrez ID: 223658
|
Does Knockout of Wdr24 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Wdr24
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Wdr24 (WD repeat domain 24)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, autophagy, cellular response to amino acid starvation, cellular response to nutrient levels, cytoplasmic translation, negative regulation of TORC1 signaling, negative regulation of translational initiation, positive regulation of TOR signaling, positive regulation of TORC1 signaling, positive regulation of macroautophagy, positive regulation of translational initiation, protein K6-linked ubiquitination, protein localization to lysosome, protein localization to plasma membrane, protein ubiquitination, regulation of autophagy; MF: metal ion binding, molecular_function, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: GATOR2 complex, cytosol, lysosomal membrane, lysosome, membrane, vacuolar membrane
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q8CFJ9
Entrez ID: 268933
|
Does Knockout of Fabp9 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Fabp9
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Fabp9 (fatty acid binding protein 9, testis)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: lipid binding, long-chain fatty acid binding; CC: acrosomal vesicle, cytoplasm, cytosol, nucleus
Pathways: Metabolism, Metabolism of lipids, Triglyceride catabolism, Triglyceride metabolism
UniProt: O08716
Entrez ID: 21884
|
Does Knockout of Gabra1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Gabra1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Gabra1 (gamma-aminobutyric acid type A receptor subunit alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to histamine, chloride transmembrane transport, chloride transport, gamma-aminobutyric acid signaling pathway, inhibitory synapse assembly, monoatomic ion transmembrane transport, monoatomic ion transport, regulation of postsynaptic membrane potential, synaptic transmission, GABAergic; MF: GABA receptor activity, GABA-A receptor activity, GABA-gated chloride ion channel activity, benzodiazepine receptor activity, chloride channel activity, diazepam binding, extracellular ligand-gated monoatomic ion channel activity, ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, monoatomic ion channel activity, protein binding, transmembrane signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: GABA receptor complex, GABA-A receptor complex, GABA-ergic synapse, chloride channel complex, cytoplasmic vesicle, cytoplasmic vesicle membrane, dendrite membrane, dendritic spine, membrane, plasma membrane, postsynapse, postsynaptic membrane, postsynaptic specialization membrane, synapse
Pathways: GABA receptor activation, GABAergic synapse - Mus musculus (mouse), Morphine addiction - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nicotine addiction - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Taste transduction - Mus musculus (mouse), Transmission across Chemical Synapses
UniProt: P62812
Entrez ID: 14394
|
Does Knockout of Pld4 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Pld4
|
phagocytosis
|
macrophage
|
Gene: Pld4 (phospholipase D family member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA metabolic process, establishment of localization in cell, hematopoietic progenitor cell differentiation, immune system process, inflammatory response, innate immune response, lipid metabolic process, phagocytosis, regulation of cytokine production involved in inflammatory response; MF: catalytic activity, exonuclease activity, hydrolase activity, nuclease activity, phospholipase D activity, protein binding, single-stranded DNA 5'-3' DNA exonuclease activity; CC: Golgi apparatus, cytoplasmic vesicle, early endosome, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, lysosome, membrane, nucleus, phagocytic vesicle, trans-Golgi network membrane
Pathways: Ether lipid metabolism - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Glycerophospholipid metabolism - Mus musculus (mouse), Immune System, Innate Immune System, Inositol phosphate metabolism, Metabolism, Role of phospholipids in phagocytosis, Synthesis of IP3 and IP4 in the cytosol, choline biosynthesis III, phospholipases
UniProt: Q8BG07
Entrez ID: 104759
|
Does Knockout of Gdf2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Gdf2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Gdf2 (growth differentiation factor 2)
Type: protein-coding
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Homozygous null mice exhibit malformations of the vasculature and skeleton. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: BMP signaling pathway, activin receptor signaling pathway, angiogenesis, blood vessel morphogenesis, branching involved in blood vessel morphogenesis, cellular response to BMP stimulus, glucose metabolic process, intracellular iron ion homeostasis, negative regulation of cell growth, negative regulation of endothelial cell migration, negative regulation of endothelial cell proliferation, neuron differentiation, ossification, osteoblast differentiation, positive regulation of BMP signaling pathway, positive regulation of DNA-templated transcription, positive regulation of Notch signaling pathway, positive regulation of SMAD protein signal transduction, positive regulation of angiogenesis, positive regulation of bicellular tight junction assembly, positive regulation of cartilage development, positive regulation of endothelial cell differentiation, positive regulation of endothelial cell proliferation, positive regulation of epithelial cell differentiation, positive regulation of gene expression, positive regulation of interleukin-8 production, positive regulation of transcription by RNA polymerase II, positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway, regulation of transforming growth factor beta receptor signaling pathway, vasculogenesis; MF: cytokine activity, growth factor activity, protein binding, protein serine/threonine kinase activator activity; CC: extracellular region, extracellular space
Pathways: Cytokine-cytokine receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by BMP, Signaling by TGFB family members
UniProt: Q9WV56
Entrez ID: 12165
|
Does Knockout of Mocs3 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Mocs3
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Mocs3 (molybdenum cofactor synthesis 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Mo-molybdopterin cofactor biosynthetic process, molybdopterin cofactor biosynthetic process, protein urmylation, tRNA processing, tRNA thio-modification, tRNA wobble position uridine thiolation, tRNA wobble uridine modification; MF: ATP binding, URM1 activating enzyme activity, adenylyltransferase activity, catalytic activity, metal ion binding, molybdopterin-synthase adenylyltransferase activity, molybdopterin-synthase sulfurtransferase activity, nucleotide binding, nucleotidyltransferase activity, sulfurtransferase activity, thiosulfate-cyanide sulfurtransferase activity, transferase activity, ubiquitin-like modifier activating enzyme activity; CC: cytoplasm, cytosol
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Molybdenum cofactor biosynthesis, Sulfur relay system - Mus musculus (mouse)
UniProt: A2BDX3
Entrez ID: 69372
|
Does Knockout of Cwf19l2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Cwf19l2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cwf19l2 (CWF19 like cell cycle control factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8BG79
Entrez ID: 244672
|
Does Knockout of Hltf in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,548
|
Knockout
|
Hltf
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Hltf (helicase-like transcription factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, chromatin organization, mRNA transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, protein polyubiquitination, protein ubiquitination, regulation of neurogenesis, replication fork reversal; MF: ATP binding, ATP-dependent activity, acting on DNA, DNA binding, DNA translocase activity, catalytic activity, helicase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, metal ion binding, nucleic acid binding, nucleotide binding, single-stranded DNA binding, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, zinc ion binding; CC: RNA polymerase II transcription regulator complex, cytoplasm, nuclear matrix, nuclear replication fork, nucleolus, nucleoplasm, nucleus
Pathways: E3 ubiquitin ligases ubiquitinate target proteins, Metabolism of proteins, Post-translational protein modification, Protein ubiquitination
UniProt: Q6PCN7
Entrez ID: 20585
|
Does Knockout of Cyp2b9 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Cyp2b9
|
cell proliferation
|
Regulatory T cell
|
Gene: Cyp2b9 (cytochrome P450, family 2, subfamily b, polypeptide 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epoxygenase P450 pathway, ketone metabolic process, response to stilbenoid, steroid metabolic process, xenobiotic catabolic process, xenobiotic metabolic process; MF: anandamide 11,12 epoxidase activity, anandamide 14,15 epoxidase activity, anandamide 8,9 epoxidase activity, arachidonate epoxygenase activity, estrogen 2-hydroxylase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, testosterone 16-alpha-hydroxylase activity, testosterone 16-beta-hydroxylase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane
Pathways: Arachidonic acid metabolism - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Retinol metabolism - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse), bupropion degradation, nicotine degradation II, nicotine degradation III
UniProt: P12790
Entrez ID: 13094
|
Does Knockout of Hdc in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Hdc
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Hdc (histidine decarboxylase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-histidine catabolic process, L-histidine metabolic process, amino acid metabolic process, carboxylic acid metabolic process, catecholamine biosynthetic process, histamine biosynthetic process, histamine metabolic process; MF: amino acid binding, carbon-carbon lyase activity, carboxy-lyase activity, histidine decarboxylase activity, identical protein binding, lyase activity, pyridoxal phosphate binding; CC: cytoplasm, dendrite, neuronal cell body
Pathways: Histidine catabolism, Histidine metabolism - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, histamine biosynthesis
UniProt: P23738
Entrez ID: 15186
|
Does Knockout of Dennd6b in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Dennd6b
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Dennd6b (DENN domain containing 6B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: guanyl-nucleotide exchange factor activity; CC: cytoplasm, endosome, recycling endosome
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q9D9V7
Entrez ID: 69440
|
Does Knockout of Tmem87a in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Tmem87a
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tmem87a (transmembrane protein 87A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to mechanical stimulus, detection of mechanical stimulus involved in sensory perception of touch, retrograde transport, endosome to Golgi; CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, cell projection, cytosol, membrane, plasma membrane, ruffle
Pathways: RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8BXN9
Entrez ID: 211499
|
Does Knockout of Ipo4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Ipo4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ipo4 (importin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, nucleocytoplasmic transport, protein import into nucleus, protein localization to nucleus, protein transport, ribosome biogenesis; MF: nuclear import signal receptor activity, nuclear localization sequence binding, protein binding, small GTPase binding; CC: chromatin, cytoplasm, nucleus, protein-containing complex
Pathways: Nucleocytoplasmic transport - Mus musculus (mouse)
UniProt: Q8VI75
Entrez ID: 75751
|
Does Knockout of Pcsk6 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Pcsk6
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Pcsk6 (proprotein convertase subtilisin/kexin type 6)
Type: protein-coding
Summary: Predicted to enable heparin binding activity; nerve growth factor binding activity; and serine-type endopeptidase activity. Acts upstream of or within determination of left/right symmetry; protein processing; and zygotic determination of anterior/posterior axis, embryo. Predicted to be active in several cellular components, including cell surface; collagen-containing extracellular matrix; and extracellular space. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and skeleton. Orthologous to human PCSK6 (proprotein convertase subtilisin/kexin type 6). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: determination of left/right symmetry, glycoprotein metabolic process, nerve growth factor production, peptide hormone processing, protein processing, proteolysis, secretion by cell, zygotic determination of anterior/posterior axis, embryo; MF: endopeptidase activity, heparin binding, hydrolase activity, nerve growth factor binding, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: cell surface, cytoplasmic vesicle, endoplasmic reticulum lumen, extracellular matrix, extracellular space, membrane
Pathways: Adherens junctions interactions, Assembly of active LPL and LIPC lipase complexes, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Expression and Processing of Neurotrophins, NGF processing, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein remodeling, Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Signal Transduction, Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Transport of small molecules
UniProt: E9Q4D0, F6XJP7, H3BJL4, H3BLN2
Entrez ID: 18553
|
Does Knockout of Adamts10 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Adamts10
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Adamts10 (ADAM metallopeptidase with thrombospondin type 1 motif 10)
Type: protein-coding
Summary: This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate a functional, zinc-dependent metallopeptidase enzyme. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: extracellular matrix organization, proteolysis; MF: endopeptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity; CC: extracellular matrix, extracellular region, microfibril
Pathways: Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, Post-translational protein modification
UniProt: P58459
Entrez ID: 224697
|
Does Knockout of Hs3st1 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Hs3st1
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Hs3st1 (heparan sulfate (glucosamine) 3-O-sulfotransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glycosaminoglycan biosynthetic process, heparan sulfate proteoglycan biosynthetic process; MF: [heparan sulfate]-glucosamine 3-sulfotransferase activity, sulfotransferase activity, transferase activity; CC: Golgi apparatus, Golgi lumen
Pathways: Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Mus musculus (mouse), Glycosaminoglycan metabolism, HS-GAG biosynthesis, Heparan sulfate/heparin (HS-GAG) metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, heparan sulfate biosynthesis, heparan sulfate biosynthesis (late stages)
UniProt: O35310
Entrez ID: 15476
|
Does Knockout of Dctn1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Dctn1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Dctn1 (dynactin 1)
Type: protein-coding
Summary: Enables microtubule binding activity. Acts upstream of or within melanosome transport. Located in cell leading edge and microtubule cytoskeleton. Part of protein-containing complex. Is expressed in brain; cerebral cortex ventricular layer; cortical plate; embryo; and head. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and autosomal dominant distal hereditary motor neuronopathy 14. Orthologous to human DCTN1 (dynactin subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell division, centriole-centriole cohesion, cytoplasmic microtubule organization, establishment of mitotic spindle orientation, melanosome transport, microtubule anchoring at centrosome, motor behavior, neuromuscular junction development, neuromuscular process, neuron cellular homeostasis, neuron projection maintenance, non-motile cilium assembly, nuclear membrane disassembly, nuclear migration, positive regulation of intracellular protein transport, positive regulation of microtubule nucleation, positive regulation of microtubule polymerization, positive regulation of neuromuscular junction development, regulation of mitotic spindle organization, retrograde transport, endosome to Golgi, ventral spinal cord development; MF: identical protein binding, microtubule binding, molecular adaptor activity, protein binding, protein kinase binding, tubulin binding; CC: axon, cell cortex, cell cortex region, cell leading edge, centriolar subdistal appendage, centriole, centrosome, ciliary basal body, cilium, cytoplasm, cytoplasmic dynein complex, cytoskeleton, cytosol, dynein complex, intercellular bridge, kinetochore, microtubule, microtubule associated complex, microtubule cytoskeleton, microtubule plus-end, mitotic spindle, neuron projection, neuronal cell body, nuclear envelope, nucleus, protein-containing complex, retromer complex, spindle, spindle pole
Pathways: AURKA Activation by TPX2, Adaptive Immune System, Amyotrophic lateral sclerosis - Mus musculus (mouse), Anchoring of the basal body to the plasma membrane, Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Cilium Assembly, ER to Golgi Anterograde Transport, G2/M Transition, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Huntington disease - Mus musculus (mouse), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Salmonella infection - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vasopressin-regulated water reabsorption - Mus musculus (mouse), Vesicle-mediated transport
UniProt: O08788
Entrez ID: 13191
|
Does Knockout of Tnr in pro-B-lymphocyte causally result in response to chemicals?
| 0
| 1,720
|
Knockout
|
Tnr
|
response to chemicals
|
pro-B-lymphocyte
|
Gene: Tnr (tenascin R)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: associative learning, axon regeneration, cell adhesion, extracellular matrix organization, locomotory exploration behavior, long-term synaptic potentiation, modulation of chemical synaptic transmission, negative regulation of axon extension, negative regulation of axon extension involved in regeneration, negative regulation of cell adhesion, negative regulation of cell-cell adhesion, negative regulation of neuron projection development, negative regulation of synaptic transmission, nervous system development, neuroblast migration, neuromuscular process controlling balance, neuron cell-cell adhesion, positive regulation of synaptic transmission, glutamatergic, positive regulation of transmission of nerve impulse, regulation of cell adhesion, regulation of cell differentiation, regulation of cell migration, synapse organization, telencephalon cell migration; MF: integrin binding, sphingolipid binding; CC: Schaffer collateral - CA1 synapse, cell surface, extracellular matrix, extracellular region, extracellular space, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, membrane raft, perineuronal net, perisynaptic extracellular matrix, tenascin complex
Pathways: ECM proteoglycans, ECM-receptor interaction - Mus musculus (mouse), Extracellular matrix organization, Focal adhesion - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse)
UniProt: Q8BYI9
Entrez ID: 21960
|
Does Knockout of Gp5 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Gp5
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gp5 (glycoprotein 5 platelet)
Type: protein-coding
Summary: Enables collagen binding activity. Involved in blood coagulation and megakaryocyte development. Acts upstream of or within cell-matrix adhesion and negative regulation of platelet activation. Predicted to be located in cell surface. Predicted to be part of glycoprotein Ib-IX-V complex. Is expressed in several structures, including hepatic primordium; liver; mesenchyme derived from splanchnopleure; placenta; and yolk sac. Orthologous to human GP5 (glycoprotein V platelet). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: blood coagulation, blood coagulation, intrinsic pathway, cell adhesion, cell-matrix adhesion, hemostasis, megakaryocyte development, negative regulation of platelet activation, positive regulation of platelet activation, release of sequestered calcium ion into cytosol; CC: cell surface, glycoprotein Ib-IX-V complex, membrane
Pathways: ECM-receptor interaction - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Platelet activation - Mus musculus (mouse)
UniProt: Q9QZU3
Entrez ID: 14729
|
Does Knockout of 1700016H13Rik in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
1700016H13Rik
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: 1700016H13Rik (RIKEN cDNA 1700016H13 gene)
Type: protein-coding
Summary: Orthologous to human C4orf36 (chromosome 4 open reading frame 36). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q9DAA3
Entrez ID: 74218
|
Does Knockout of Sin3b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Sin3b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Sin3b (transcriptional regulator, SIN3B (yeast))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac muscle tissue development, negative regulation of DNA-templated transcription, negative regulation of cell cycle, negative regulation of cell migration, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell cycle, skeletal muscle tissue development; MF: chromatin binding, protein binding, transcription corepressor activity; CC: Sin3-type complex, X chromosome, XY body, Y chromosome, autosome, chromatin, cytoplasm, nucleus
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cytoprotection by HMOX1, Gene expression (Transcription), Generic Transcription Pathway, Metabolism, Metabolism of lipids, RNA Polymerase II Transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Regulation of lipid metabolism by PPARalpha, Transcriptional regulation by RUNX1
UniProt: Q62141
Entrez ID: 20467
|
Does Knockout of Lrwd1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Lrwd1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Lrwd1 (leucine-rich repeats and WD repeat domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, chromatin organization, establishment of protein localization to chromatin; MF: chromatin binding, histone H3K27me3 reader activity, methyl-CpG binding; CC: centrosome, chromosome, chromosome, centromeric region, chromosome, telomeric region, cytoplasm, cytoskeleton, kinetochore, nuclear origin of replication recognition complex, nucleolus, nucleoplasm, nucleus, pericentric heterochromatin
Pathways:
UniProt: Q8BUI3
Entrez ID: 71735
|
Does Knockout of Trim54 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Trim54
|
cell proliferation
|
Regulatory T cell
|
Gene: Trim54 (tripartite motif-containing 54)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, innate immune response, negative regulation of microtubule depolymerization; MF: metal ion binding, microtubule binding, protein binding, ubiquitin protein ligase activity, zinc ion binding; CC: Z disc, cytoplasm, cytoskeleton, microtubule, microtubule associated complex
Pathways:
UniProt: Q9ERP3
Entrez ID: 58522
|
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