Conversation: The conversation between human and AI assistant.
[|Human|] Hi. I am a 49 yr old female & have been taking Prozac (20 mg daily) for about a year. Lately, Ive noticed an increase in my depression (lethargic, sad, suicidal thoughts).It was a tremendous help to me until recently, could it be that I have developed a tolerance or should possibly be on a higher dose?
[|AI|]  Hi, I can understand your concern regarding the re-emergence of your depressive symptoms, especially while you are still on anti-depressants. It is not due to any development of tolerance to Prozac (Fluoxetine). It is a known phenomenon and occurs quite commonly in depression. Furthermore, it is termed as breakthrough depression. You should consult your psychiatrist regarding the same. The first step will be to hike the dose of Fluoxetine further up initially to 40 mg/day and more if required (can be tried up to 80 mg/day). If you attain no response on hiking the dose, another anti-depressant like venlafaxine can be tried. I do hope that I was able to answer your query. Best wishes for a speedy recovery.