Conversation: The conversation between human and AI assistant.
[|Human|] Hello Dr and thankyou for taking this query. I am currently on chemotherapy for Multiple myeloma which was diagnosed before sympoms appeared - I  55 ys of age,  female and under good care for my condition. I am taking lots of different drugs in conjunction with my velcade + cycolphosmide(?)  treatment  and just wanted to know what each is for as - particularly enteclovir and barachlude, (not sure of spelling) - can you help?many thanksOriana
[|AI|]  Hello, Welcome to Chat Doctor. Thanks for your query. I have gone through your query and understand your concern. Velcade contains Bortezomib. It is proteasome inhibitor. In normal cells, the proteasome regulates protein expression and function by degradation of ubiquitylated proteins, and also cleanses the cell of abnormal or misfolded proteins. In myeloma cells, Bortezomib proteasome inhibition may prevent degradation of pro-apoptotic factors, permitting activation of programmed cell death in neoplastic cells dependent upon suppression of pro-apoptotic pathways. Cyclophosphomideis a nitrogen mustard alkylating agent. The main effect of cyclophosphamide is due to its metabolite phosphor amide mustard. This metabolite is only formed in cells that have low levels of ALDO. Phosphoramide mustard forms DNA cross links both between and within DNA strands at guanine N-7 positions (known as interstrand and intrastate cross linkages, respectively). This is irreversible and leads to cell death. Entecavir is a Arcade. Entecavir is an oral antiviral Chat Doctor. Hope this helps. Please reply for further queries. Wishing you good health.