Conversation: The conversation between human and AI assistant.
[|Human|] I had the cancer Rhabdomysarcoma and underwent treatment when I was 21.  I am no 26 and cancer free.  I recently got married and am curious if the chemo or radiation I had could have made me sterile.  The tumor was in my sinus and so the radiation was focused on the head and neck regions.  The chemos I took were, Etoposide, Ifosfamide and Vincristine and Doxorubicin.  Thanks.
[|AI|]  Hi, Thanks for writing in. Etoposide can cause reduced ovarian reserve in females and infertility in males. Males appear more susceptible than females to ifosfamide genotoxicity. There may be a dose in males below which the risk of subfertility is low. In females there is preliminary evidence of reduction in ovarian reserve, which may potentially lead to an early menopause and a reduction in the window of fertility. Vincristine is typically less likely to harm fertility. Some of these Chat Doctor. In females of reproductive potential, Doxorubicin may cause infertility and result in amenorrhea. Premature menopause can occur. Recovery of menses and ovulation is related to age at treatment. Doxorubicin may result in oligospermia, azoospermia, and permanent loss of fertility. Sperm counts have been reported to return to normal levels in some men. This may occur several years after the end of therapy