Conversation: The conversation between human and AI assistant.
[|Human|] Hi there. I was born in 1960...the third of three daughters. My mother is negative blood type...my sisters and I all positive blood type. Her pregnancy with me was non-thriving and suspicious. I was induced a few weeks early as a result. I had a non-thriving look. In later decades it was learned that my mother was RH negative, and each subsequent pregnancy became dangerous to the fetus (me). I know that I did not undergo a blood transfusion after birth. I am 50 years old now, and have been undergoing blood work and endless doctor appointments to find answers to a multitude of symptoms....all pointing to autoimmune disorders. (My mother now has Lupus). My own ANA level has recently starting to elevate. I exhibit symtoms of either Multiple Sclerosis, or Lupus, or anything at all...but nothing conclusive shows in blood work or MRI s from 2009. I was a little anemic in my twenties, but no longer. I am post-menopausal for 6 years already. When I was in my early twenties I contracted three autoimmune illnesses back-to-back within a couple of years....Chicken Pox / Measles / Mononucleosis. My question is this.....I try to connect the dots and arm myself with new theories whenever I go to my Rheumotologist. Is there any such thing as being vulnerable for disease for those babies that were contaminated by the RH factor? Thank you so much.......Randie Lucano
[|AI|]  Dear Randi. I will add Chat Doctor.  Research evidence shows that there is a connection with HLA types that is there maybe a genetic predisposition in some families. Regarding the Rh blood group, inconclusive evidence. Prior to the development of The Rh immunoglobulin Rh negative moms of the 60s and 70s did not receive it. Not all Rh negative moms mounted an immune response so in that case the babies were OK or else they didn't survive or had serious problems. For a diagnosis of lupus we have certain criteria which is a minimum of four criteria called ACR criteria. ANA positivity is one of them. Along with the patient has a rash on the cheeks, joint pain, anemia, kidney problems etc. Lupus has different levels of severity and requires assessment by an immunologist. Sometimes lupus may be associated with other autoimmune diseases. If you were diagnosed with Lupus by an immunologist or rheumatologist, you have to periodically go in for a check-up. There is effective modern therapy for autoimmune diseases if present and the quality of life is generally good with effective medical monitoring. Should you have any further queries please post them here so that I may assist you in interpretation of your medical reports? Best regards