Conversation: The conversation between human and AI assistant.
[|Human|] our son is 7 months old, he is having enlarged liver and spleen as per the ultrasound scan. he is having jaundice from last 1.5 months. Tourch test was done and everything came as non reactive. since the cause is not know, liver biopsy is done and we were asked to consult after one week. What can be the causes of jaundice, liver and spleen enlargement?
[|AI|]  Hello,1) Enlargement of liver + spleen may be due to portal hypertension.2) It is a condition in which pressure in portal vein (supply blood from intestine to liver) increase. Because of increased pressure in portal vein, blood flow to liver decrease and blood divert to spleen which cause enlargement of spleen.3) Generally, if blockage into portal vein before it enter liver cause portal hypertension but without liver enlargement.4) Lesion of liver or blockage of portal vein inside liver cause portal hypertension with liver enlargement. And this also develop jaundice5) In such cases, biopsy of liver is mandatory to find out exact cause, but upper GI endoscopy is also essential as portal hypertension cause enlargement of veins at lower part of esophagus (which might cause blood containing vomiting if rupture).