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[|Human|] I have had about of optic neuritis and my MRI was normal with only 1 hyperintensity lesion. Neurologist has ruled out MS and optic neuritis probably viral. I am now on Prednisone and I have severe tingling in my hands and feet. Could the Prednisone be doing it or could I have MS.
[|AI|]  Hi, Thanks for writing in. Numbness, burning, or tingling in the face, arms, legs, feet or hands can be due to serious side effect of taking prednisone. This is considered one of the serious side effects and must be communicated to your doctor urgently. MS is a condition that can have any of the neurological symptoms, but the diagnosis is based on a criterion found on MRI imaging. This is the McDonald criteria and MS is suspected only if there is appearance of new lesions on follow-up MRI with spatial and temporal reference and the lesions showing certain characteristics in pattern and distribution. If your doctor has seen your MRI and said there are no features of MS then you probably do not have the condition. However, you can observe and express your symptoms in the coming months to your doctor and discuss if repeat imaging by MRI might be required after few months, depending on the progress of symptoms.