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[|Human|] My husband has polycystic kidney disease (the dominant type) I am curious if we could have a child with the recessive type. I know the genetic mutation is on two different genes. So would it be possible for our child to have the recessive type which is more severe or would they only be able to inherit the dominant type?
[|AI|]  Hi, Thanks for writing in. Autosomal dominant PKD is the most common inherited disorder of the kidneys. The phrase "autosomal dominant" means that if one parent has the disease, there is a 50 percent chance that the disease gene will pass to a child. Autosomal recessive PKD is caused by a mutation in the autosomal recessive PKD gene, called PKHD1. Other genes for the disease might exist but have not yet been discovered by scientists. It is not possible for autosomal dominant polycystic kidney disease father to have autosomal recessive polycystic child. So your child might have risk of autosomal dominant but never autosomal recessive polycystic kidney disease.