Conversation: The conversation between human and AI assistant.
[|Human|] Dear Doctor, If Parkinson s disease is due to diminishing dopamine production in brain then it should be compensated by external supply by medicines. Then why these medicines are not useful after some time. I assume the problem is not only the reduced supply of dopamine but there exist some other faults in the mechanism of utilization of dopamine. Can you let me know some detail or inform me about the web page where I can read about it. Thanks. Iqbal : Email : YYYY@YYYY
[|AI|]  Hi, Thank you for posting your query. Dopamine depletion is a part if the problem in Parkinson's disease. The problem with giving external dopamine is that it does not fully go to the brain, it remains in the blood and goes to other organs as well, leading to various side effects. Also, the natural dopamine is available round the clock, which can not be achieved with external dopamine supplements. Best wishes, Chat Doctor.