Conversation: The conversation between human and AI assistant.
[|Human|] 1.a patient suffering from CA cervix treated with radiotherapy landing into uraemia...... is there any relation between radiotherapy and uraemia in CA cervix patient? 2.what are the chances of aggravation of TB in pregnancy? which trimester is more susceptible?
[|AI|]  Hello, Yes, definitely there is. The kidneys are the dose-limiting organs for radiotherapy to upper abdominal cancers and during total body irradiation.  The incidence of radiotherapy-associated kidney injury is likely under-reported owing to its long latency and because the toxicity is often attributed to more common causes of kidney injury.  The pathophysiology of radiation injury is poorly understood. Its presentation can be acute and irreversible or subtle, with a gradual progressive dysfunction over the years.  A variety of dose and volume parameters have been associated with renal toxicity and are reviewed to provide treatment guidelines. Hope I have answered your query. Let me know if I can assist you further. Take care Chat Doctor.