Conversation: The conversation between human and AI assistant.
[|Human|] My wife is suffering from mild scleroderma, now the skin of face and neck have become very supple. she was treated with Methotrexate for 2 weeks.Now she has fibromyalgia symptoms with neuritic pain left leg and anaesthesia in left foot. Sural nerve biopsy was done which showed polyneuritis.She cant walk , becomes breathless.She has reflux oesophagitis, proved by endoscopy. Angiogram was done it is normal.She is on pregabalin 75 mg BD. She has mild pedal oedema. She has sleeplessness also.It is bizarre of symptoms.I will be glad if you can throw some light
[|AI|]  Hi, Scleroderma is a chronic systemic autoimmune disease (primarily of the skin -"dermal") characterized by fibrosis (or hardening -"sclera"), vascular alterations, and autoantibodies. There are two major forms:Limited systemic sclerosis/scleroderma involves cutaneous manifestations that mainly affect the hands, arms, and face. It was previously called CREST syn Chat Doctor.  Additionally, pulmonary arterial hypertension may occur in up to one-third of patients and is the most serious complication for this form of scleroderma. Diffuse systemic sclerosis/scleroderma is rapidly progressing and affects a large area of the skin and one or more internal organs, frequently the kidneys, esophagus, heart, and lungs. This form of scleroderma can be quite disabling. There are no treatments for scleroderma itself, but individual organ system complications are treated. Immunosuppressants like steroids' methotrexate, except, azathioprine are used to suppress the immune mechanism. Since the disease also cause vasculitis of small vessels supplying nerves hence they can also have poly neuritis which in turn produce pedal edemaContinue with Pregabalin and along with it, she also requires methylcobal supplements prognosis is generally good for limited cutaneous scleroderma patients who escape pulmonary complications, but is worse for those with the diffuse cutaneous disease, particularly in older age, and for males. Regards