Conversation: The conversation between human and AI assistant.
[|Human|] I am a 64 yr old female that was diagnosed three years ago with anti synthase syndrome. I have now been also diagnosed with scleroderma. Wondering if there is some sort of medical info in print that might help me better understand just what part of my symptoms are anti synthetase and what are scleroderma based. Initially the diagnosis was polymyositis and seemed to escalate from there. I trust my doctors but also wondering about 2nd opinions
[|AI|]  Hello, I understand your concern because it is a little difficult to understand exactly from which diagnose some symptoms come. Well at first to know, it is that they both are autoimmune disease, that means that your body attacks his cells (create antibody anti some specific cell in the organism). And the diagnosis it is confirmed from these antibodies, in this case they are called autoantibodies. Antisynthetase has antibody anti Aminoacyl-tRNA synthase (an enzyme), and scleroderma, depending on what kind of, has different antibodies. Both of this disease have some symptoms that can overlapping, or the same, because they both touch lungs and fingers like Ranked phenomena. But just to remember, scleroderma attacks the skin first (so symptoms which are correlated with skin as : redness, swelling, tenderness, itching are due to this) and another thing to remember in scleroderma it is that usually touch the skin of face, neck fingers and foot. Symptoms that are more specific for antisynthtase they are correlated with muscles(weakness) but also you can have arthritis. As they both are autoimmune disease, both of them cause fatigues and weight loss. I hope that my answer is helpful to you! Best regards! Chat Doctor.