Conversation: The conversation between human and AI assistant.
[|Human|] I was taking methotrexate once a week then Humira pen every other week then my doctor took me off the methotrexate changed my humria to every 3 weeks for 3 months course and now humira once monthly now m y psoriasis has returned why would he do this I was doing great before the changes started I have been on these drugs for about 8 years
[|AI|]  Hello. Thank you for writing to Samira Or golimumab is a human monoclonal antibody that targets the inflammatory pathway that is involved in psoriasis. Adalimumab is generally administered every 2 weeks. Though it is very effective in controlling and improving psoriasis scores, but it can be associated with serious side effects like re-activation of Tuberculosis, hepatitis and increased risk of opportunistic infections (bacterial, viral and fungal). Therefore, attempt should always be made to taper it off once psoriasis is under good control. I think your physician did try to do the same. However, since psoriasis is recurrent disease and can recur even while the patient is on golimumab. This is known as secondary failure i.e. recurrence in spite of being on treatment. In this scenario I would suggest reverting to once weekly dose for 2 weeks and then maintain with once every 2 weeks doses. I suggest that you talk to your doctor for the needful. Regards