Conversation: The conversation between human and AI assistant.
[|Human|] Hi Doctor, I have diagnosed with iga nephropathy & now i am having methylprednisolone 48mg/day since 24th Sep. But two days ago i have got a severe knee pain in the middle of the night & it was terrible. Kindly advise why this has happened & is it becoz of the pred? Also my legs & face got swollen as well. B Rgds, Lalindra.
[|AI|]  Hi there, IgA nephropathy is associated with protein leak in urine. If protein leak is too much or associated with increase salt and water intake it can lead to rapid increase in swelling. Also if patient develops kidney dysfunction with rise in serum creatinine levels it can lead to decrease in urine and sudden increase in swelling. IGA nephropathy can be associated with HSP, a condition which can have progressive disease with knee pain. Paient on steroids can develop infection which may present with knee pain. All these possibilities are there but a good examination by nephrologist and investigations will give the answer. Contact your doctor as soon as possible