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[|Human|] for nephrologist respected dr ,i am renal transplant recipient 3yr ago,my Hb is 10.2 gm/dl ,creatinine 1.4 .i am on mycophenolate 360mg tds and tacrolimus 1mg/1.5mg no steroid /earlier my creatinine remained around 1/1.2 mg my tacro level came out to be 15.7 today earlier 6 month back it was 6.0 / i m gonna get it repeated kindly advise thanx
[|AI|]  Hi, It is necessary to know first what the range of normal levels for Tacrolimus (Macro) for the laboratory that tested your blood is to know whether the 15.7 is considered significant or not.  Some authors would say that limits for tacrolimus are 5-10 while others allow the upper limit to ride out to 15.  Therefore, if the lab range is the former you would be approximately 50% above normal and this could signal too much tacrolimus in your system.  If the lab range is the latter then, the result of 15.7 is not significantly higher than normal... unless you are feeling some sort of symptom or experiencing some sort of organ insufficiency or failure over the past 6 months making it a significant number.  Remember, in medicine often it's not the absolute number of a particular lab that is as important as the amount of change or even the rate of change of a parameter or chemical substance which determines the significance of that number.  Your doctor who ordered the test would be best able to tell you if everything is fine or if adjustments need to be made to your medication. Hope I have answered your query. Let me know if I can assist you further.