Conversation: The conversation between human and AI assistant.
[|Human|] In 2010 I was diagnosed with Latent TB. Took the medication that was prescribed to me and completed. Well while taking it, I was always concerned if the 300mg Isoniazid would interfere with my sperm meaning an accidental malformation with it or a malformation should a baby come into the picture. So in short did i have a reason to be worried?
[|AI|]  Hereafter reading of your query I want to tell you that INH is completely absorbed orally and penetrates all body tissues (including prostate and testis), tubercular cavities, placenta (in pregnant woman) & meninges. Metabolized in liver through ACETYLATION. The rate of ACETYLATION shows genetic variation but not interfere in sperms morphology in any way. Half life of INH is t 1/2 of INH 1 hour in fast acetylation, while in slow it is 3 hours. All these I mentioned in detail, so that you understand that only genetic variation take place in acetylation and this is part of metabolism in liver. So in my opinion no genetic modification in sperm or baby. Hope this will be useful and will get rid of worry.