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[|Human|] 36 year old female, 131 lbs., 5 5 expiereincing chest pressure, shortness of breath, lost nearly 15 lbs in past 8 weeks without trying, fatigued, pain in neck, shoulder, and back. all test have come back normal except an ANA test. been to the er twice and frustrated with how i m being treated! just need an answer
[|AI|]  Hello thanks for posting at Chat Doctor. Your symptoms like shortness of breath, loss of weight, chest pressure, fatigue can be symptoms of anemia. But since you have worked up, I guess hemoglobin levels would have been checked and found normal. Another possibility is chest infection. You have mentioned that tests are normal, but not which tests have been done. I want to know whether a chest x-ray and a CT of the chest has been done. If not please get a CT chest done. It will show if you have some infection patches in the lungs. If infection patches are present, samples from those areas can be taken by bronchoscopy for testing. Possibility of tuberculosis should also be considered here. Since your ANA is positive then the symptoms can be due to autoimmune disease also. But again it depends on the intensity of ANA, its final dilution and its pattern. Please share information about the full ANA report. ANA positivity can affect lungs, kidneys and other organs also. Please do a urine routine and creatinine (if not already done) to see if kidney functions are affected. Please revert with the above findings. Wishing you good healthRegards