Conversation: The conversation between human and AI assistant.
[|Human|] Hai sir,I am sunitha,25 years from Hyderabad.I have ichthyosis since my childhood but i am unable to mingle with the society because of my problem. Can it be cured at least in future days?As of now i came to know there is no permanent solution for this being a by birth problem.Please suggest me how to keep moisture in my body.I get sweat only to my face.Can it be possible to get sweat all over the body by any of the alternatives?Suggest me any creams or solutions.
[|AI|]  Hello. Thank you for writing to us. Ichthyosis literally means fish like, and it refers to the type of scaling seen in ichthyosis. Ichthyosis can be genetic or acquired. Genetic ichthyosis is due to a gene mutation that impairs the normal function of epidermal barrier. The inheritance of this defective gene mutation may be autosomal dominant or recessive. Icthyosis vulgarism(IV) e.g. is caused by autosomal dominant flagging gene mutation and X- linked recessive ichthyosis(LRI) by X linked recessive steroid sulfate mutation. These are the two most common types of ichthyosis. Apart from these other types of ichthyosis like Patellar ichthyosis(LI), Congenital ichthyosiform erythroderma(CIE), Non-bullous ichthyosiform erythroderma(NBIC) are rarer but more severe. Goal of treatment in genetic ichthyosis is to keep the disease severity under control i.e. it is palliative. There is no permanent cure for genetic ichthyosis. Treatment includes topical urea, lactic acid, salicylic acid based moisturizers. Oral treatment is with Oral retinoids e.g. accretion for thick keratitis involvement of skin. There is a lot of research particularly gene based research that is going on and it may be possible in future to correct the genetic defect responsible in ichthyosis. Regards