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0 | ['MeC', 'Me', 'HOC', 'PdCI2(PPh3)2(5% mol),', 'Ph', 'ph', 'CHO', 'TFE/EtOH 1:1', 'HCO2H (1 eq)', 'NH2', '30C,24 h', 'MeCN/Et3N 1:1', 'tBu-NC', 'BI', '85C,18h', 'MeO', 'OMe', '1 (83%)', 'work up and crystallization', '-', 'Ph', 'PH', 'OHMeCN,DBU', 'TFA/CHCl2', 'OMe', 'r.t., 4 h', '1:2, r.t., 2 h', 'VF', 'OMe', 'ISO-1 (61%,3 steps),1.70 gr', '3', '2 (Z/E 10:1)', 'work up and crystallization', 'work up', 'work up and filtration on celite'] | {'Ugi reaction': [{'substrate': ['MeC', 'Me', 'HOC', 'PdCI2(PPh3)2(5% mol)', 'Ph', 'ph', 'CHO', 'TFE/EtOH 1:1'], 'products': ['NH2', 'HCO2H (1 eq)', 'MeO', 'OMe', '1 (83%)']}], 'Reductive Heck reaction': [{'substrate': ['1 (83%)'], 'products': ['MeCN/Et3N 1:1', 'tBu-NC', 'BI', '85C,18h', '2 (Z/E 10:1)']}], 'Aromatization': [{'substrate': ['2 (Z/E 10:1)'], 'products': ['Ph', 'PH', 'OHMeCN,DBU', 'TFA/CHCl2', 'OMe', 'r.t., 4 h', '1:2, r.t., 2 h', 'VF', 'OMe', 'ISO-1 (61%,3 steps),1.70 gr', '3']}]} | |
1 | ['2 mol%Pd(OAc)2', '4 mol% SPhos', 'Ar(Het-X', 'ZnI*LiCI', 'THF.25C,16 h', '(Het)Ar', 'X=I,BrCI', '4a', '5a-l:73-98%[a]', '1.0 equiv', '1.2 equiv', 'OMe', 'COE', '5a:98%X=Br', '5b95%X=I', '5c83%,X=I', '5d97%X=l', '5e85%X=', '5f:83%X=Br', '5g:95%X=CI', '5h90%,X=Br', '4 mol% Pd(PPh3)4', 'ZnI*LiCI', 'THF.25C or 50C.16 h', '4a', '5i-I73-87%[a]', '1.0 equiv', '1.2 equiv', 'OMe', '5i:87%', '5j:82%', '5k73%', '51:83%'] | {'Pd(OAc)2': [{'substrate': ['Ar(Het-X', 'ZnI*LiCI'], 'products': ['5a-l:73-98%[a]']}], 'SPhos': [{'substrate': ['Ar(Het-X', 'ZnI*LiCI'], 'products': ['5a-l:73-98%[a]']}], 'Pd(PPh3)4': [{'substrate': ['ZnI*LiCI'], 'products': ['5i-I73-87%[a]']}]} | |
2 | ['ZnI LiCl', '2 mol% Pd(OAc)2', 'Ar-X', '4 mol%SPhos', 'THF,25C,16 h', 'X=BrI', '4b-e', '6-9:75-99%[a]', '1.0 equiv', '1.2 equiv', 'Me', 'Me', 'Me', 'OMe', 'COMe', '(S-6a 83%,>95% ee', 'R)-6b 86%,98% ee', 'R)-6c 91%98% ee', 'M', 'OMe', 'NH', '(S)-6d 99%99%ee', 'S)-7a 93%,99% ee', '(S)-7b 89%,99%ee', '-', 'CHO', 'S)-7c 92%,99% ee', 'S)-7d 88%,99% ee', 'S)-7e 93%,99% ee', 'OMe', 'CHO', 'COE', 'S)-8a 84%,99% ee', 'S-8b 91%99% ee', 'S-8c 96%,99% ee', 'Ph', 'OMe', 'NH2', '(S)-8d 95%,99% ee', '(R)-9a 75%,99% ee', '(R)-9b 75%,99% ee', 'Ph', 'CHO', 'CN', 'R-9c 80%99% ee', 'R-9d 92%99%ee', 'R-9e 85%.99%ee'] | {'ZnI LiCl': [{'substrate': ['Ar-X', '4b-e'], 'products': ['6-9:75-99%[a]']}], '2 mol% Pd(OAc)2': [{'substrate': ['Ar-X', '4b-e'], 'products': ['6-9:75-99%[a]']}], '4 mol%SPhos': [{'substrate': ['Ar-X', '4b-e'], 'products': ['6-9:75-99%[a]']}], 'THF,25C,16 h': [{'substrate': ['Ar-X', '4b-e'], 'products': ['6-9:75-99%[a]']}], 'X=BrI': [{'substrate': ['Ar-X', '4b-e'], 'products': ['6-9:75-99%[a]']}]} | |
3 | ['[a] 4 moI% Pd(PPh3)4', 'ZnI-LiCl', 'THF,25or 50C,16 h', '[b] 10 mol% Cul', '4b-e', 'THF,0-25C16h', '6-9:66-86%[c]', '1.0 equiv', '1.2 equiv', 'R)-6e 73%[bl,99% ee', 'R)-6f 67%[b],99% ee', 'R)-6g 79%lb),99% ee', 'OMe', 'Me', 'R)-6h 59%bl,99% ee', 'S-7f85%[a],99%ee', 'S)-7g 80%(b], 99% ee', 'OEt', '(S)-7h 70%(bl, 99% ee', 'S)-7i 72%a],99% ee', '(S)-7j 66%[al, 99% ee', 'OMe', 'S)-8e 86%al,99% ee', 'S-8f85%[a99% ee', 'R-8f 82%a),99% ee', 'COEt', '(S)-8g 84%a],99% ee', '(S)-8h 70%[a],99% ee', 'S)-9f 80%[b],99%ee'] | {'Pd(PPh3)4': [{'substrate': ['4b-e', 'R)-6e', 'R)-6f', 'R)-6g', 'R)-6h', 'S-7f', 'S)-7g', 'S)-7h', 'S)-7i', 'S)-7j', 'S)-8e', 'S-8f', 'R-8f', 'S)-8g', 'S)-8h', 'S)-9f'], 'products': ['OMe', 'Me', 'OEt', 'COEt']}], 'CuI': [{'substrate': ['4b-e', 'R)-6e', 'R)-6f', 'R)-6g', 'R)-6h', 'S-7f', 'S)-7g', 'S)-7h', 'S)-7i', 'S)-7j', 'S)-8e', 'S-8f', 'R-8f', 'S)-8g', 'S)-8h', 'S)-9f'], 'products': ['OMe', 'Me', 'OEt', 'COEt']}]} | |
4 | ['MeO', 'OMe', 'Mel 3 equiv)', 'NaBH4', 'OH', 'NaOAc', 'KOH(3 equiv', '1.5 equiv', 'L-tyrosine', 'DCE/HO/AcOH', 'DMF,0-25C', 'EtOH,0-25C', 'MeO', '90C,16 h', '24 h', '4 h', 'S)-2g:40%,3 steps', 'PPh3,limidazole1.1 equiv', 'DCM,0-25C,3h', 'Zn (1.5 equiv)', 'ZnI LiCl', 'LiCi (1.0 equiv)', 'MeO', 'MeO', 'R-X', 'MeO', 'THF,25C', '1.2 equiv', 'X=I,CI', 'S-3g95%', '15 min', '(S)-4g:99%', 'THF,16 h', 'S11a-f:75-96%', '92%ee', 'COMe', 'Me', 'MeC', 'MeO', 'MeC', 'Me', 'CN', 'S)-11a:95% yiela[a]', 'S)-11b:96% yield[a]', 'S)-11c: 93%yiela[a]', 'X=I92%ee', 'X=I.92%ee', 'X=I92%ee', 'Br', 'MeC', 'Mec', 'S)-11d:78% yield[b]', 'S)-11e:84% yiela[c]', 'S)-11f: 75%yield[c]', 'X=CI,92%ee', 'X=CI,92%ee', 'X=CI,92% ee', '[a]2 mol% Pd(OAc)2.4 mol% SPhos,25C', '[b] 4 mol% PdPPh)4.25C', '[c]10 mol% Cul,0-25C'] | {'NaBH4': [{'substrate': ['MeO'], 'products': ['OH']}], 'NaOAc': [{'substrate': ['OH'], 'products': ['MeO']}], 'KOH': [{'substrate': ['MeO'], 'products': ['MeC']}], 'PPh3/limidazole': [{'substrate': ['MeC'], 'products': ['MeO']}], 'Zn': [{'substrate': ['MeO'], 'products': ['S-3g']}], 'LiCl': [{'substrate': ['S-3g'], 'products': ['S-4g']}], 'Pd(OAc)2/SPhos': [{'substrate': ['S-4g'], 'products': ['S-11a']}], 'PdPPh3': [{'substrate': ['S-4g'], 'products': ['S-11d']}], 'CuI': [{'substrate': ['S-4g'], 'products': ['S-11e', 'S-11f']}]} | |
5 | ['Eriodictyol', 'Naringenin', "3'-Me-E", "3'4'-DiMe-E", 'Product 3', '7-Me-N', 'Product2', '100', '100', '75', '75', 'Area1%', '50', '25', '25', 'leOMTT133M', 'T133M T133M T133M T133M T133M T133M', 'leOMTT133M', 'T133M T133M T133M T133M T133M T133M', 'L322H L322N L322M Y326H Y326R Y326L', 'L322HL322NL322M Y326H Y326RY326L', 'Luteolin', 'Quercetin', "3'-Me-L", "3',4'-DiMe-L", "3'-Me-Q", "3'4'-DiMe-Q", 'Product 3', '100', '100', '75', '75', 'Area%', '50', '25', '25', 'leOMTT133M', 'leOMTT133M', 'T133M T133M T133M T133M T133M T133M', 'L322H', 'L322NL322M Y326H Y326RY326L', 'L322H', 'L322N', 'L322M', 'Y326HY326R', 'Y326L', 'Genistein', '7-Me-G', "4'-Me-G", 'Product 3', '100', '75', '25', 'leOMT', 'T133M', 'T133M T133M T133M T133M T133M T133M', 'L322H', 'L322N L322M Y326H Y326R Y326L'] | {'IeOMT': [{'substrate': ['Eriodictyol', 'Naringenin'], 'products': ["3'-Me-E", "3'4'-DiMe-E", '7-Me-N']}, {'substrate': ['Luteolin'], 'products': ["3'-Me-L", "3',4'-DiMe-L"]}, {'substrate': ['Quercetin'], 'products': ["3'-Me-Q", "3'4'-DiMe-Q"]}, {'substrate': ['Genistein'], 'products': ['7-Me-G', "4'-Me-G"]}], 'IeOMT T133M': [{'substrate': ['Eriodictyol', 'Naringenin'], 'products': ["3'-Me-E", "3'4'-DiMe-E", '7-Me-N']}, {'substrate': ['Luteolin'], 'products': ["3'-Me-L", "3',4'-DiMe-L"]}, {'substrate': ['Quercetin'], 'products': ["3'-Me-Q", "3'4'-DiMe-Q"]}, {'substrate': ['Genistein'], 'products': ['7-Me-G', "4'-Me-G"]}], 'IeOMT L322H': [{'substrate': ['Eriodictyol', 'Naringenin'], 'products': ["3'-Me-E", "3'4'-DiMe-E", '7-Me-N']}, {'substrate': ['Luteolin'], 'products': ["3'-Me-L", "3',4'-DiMe-L"]}, {'substrate': ['Quercetin'], 'products': ["3'-Me-Q", "3'4'-DiMe-Q"]}, {'substrate': ['Genistein'], 'products': ['7-Me-G', "4'-Me-G"]}], 'IeOMT L322N': [{'substrate': ['Eriodictyol', 'Naringenin'], 'products': ["3'-Me-E", "3'4'-DiMe-E", '7-Me-N']}, {'substrate': ['Luteolin'], 'products': ["3'-Me-L", "3',4'-DiMe-L"]}, {'substrate': ['Quercetin'], 'products': ["3'-Me-Q", "3'4'-DiMe-Q"]}, {'substrate': ['Genistein'], 'products': ['7-Me-G', "4'-Me-G"]}], 'IeOMT L322M': [{'substrate': ['Eriodictyol', 'Naringenin'], 'products': ["3'-Me-E", "3'4'-DiMe-E", '7-Me-N']}, {'substrate': ['Luteolin'], 'products': ["3'-Me-L", "3',4'-DiMe-L"]}, {'substrate': ['Quercetin'], 'products': ["3'-Me-Q", "3'4'-DiMe-Q"]}, {'substrate': ['Genistein'], 'products': ['7-Me-G', "4'-Me-G"]}], 'IeOMT Y326H': [{'substrate': ['Eriodictyol', 'Naringenin'], 'products': ["3'-Me-E", "3'4'-DiMe-E", '7-Me-N']}, {'substrate': ['Luteolin'], 'products': ["3'-Me-L", "3',4'-DiMe-L"]}, {'substrate': ['Quercetin'], 'products': ["3'-Me-Q", "3'4'-DiMe-Q"]}, {'substrate': ['Genistein'], 'products': ['7-Me-G', "4'-Me-G"]}], 'IeOMT Y326R': [{'substrate': ['Eriodictyol', 'Naringenin'], 'products': ["3'-Me-E", "3'4'-DiMe-E", '7-Me-N']}, {'substrate': ['Luteolin'], 'products': ["3'-Me-L", "3',4'-DiMe-L"]}, {'substrate': ['Quercetin'], 'products': ["3'-Me-Q", "3'4'-DiMe-Q"]}, {'substrate': ['Genistein'], 'products': ['7-Me-G', "4'-Me-G"]}], 'IeOMT Y326L': [{'substrate': ['Eriodictyol', 'Naringenin'], 'products': ["3'-Me-E", "3'4'-DiMe-E", '7-Me-N']}, {'substrate': ['Luteolin'], 'products': ["3'-Me-L", "3',4'-DiMe-L"]}, {'substrate': ['Quercetin'], 'products': ["3'-Me-Q", "3'4'-DiMe-Q"]}, {'substrate': ['Genistein'], 'products': ['7-Me-G', "4'-Me-G"]}]} | |
6 | ['SeO', 've', 'Br', 'Me', '1,4-dioxane', "100 'C,56 h", '18g', '76%', '24', 'MeO?', '(CO,Me)CH,ZnBr', 'Me', 'THF', 'rt, 1 h', '19g', '99%', '25', 'MeS', 'RuCl3 NaIO4', 'MeC', 'MeCN,CCI4 H2O', 'rt, 75 min', '19g', '26', '92%'] | {'SeO2': [{'substrate': ['18g'], 'products': ['24']}], '(CO,Me)CH,ZnBr': [{'substrate': ['19g'], 'products': ['25']}], 'RuCl3 NaIO4': [{'substrate': ['19g'], 'products': ['26']}]} | |
7 | ['5 mol-% 8/Ti(OiPr)4', 'TMSCN', 'NC', 'OBn', 'OBn', 'CHCl2,-20C', 'OTMS', '.', '75% yield,80% ee', '10', '1HCI in EtOH,89% yield', '2)MeONHMe.HCI', 'MeO', 'iPrMgCI,84% yield', 'OBn', 'Amphidinolides', '3)DMSO,AcOH', 'G and H', 'OTMS', 'AcO60% yield', '11'] | {'8/Ti(OiPr)4': [{'substrate': ['TMSCN', 'NC', 'OBn', 'OBn', 'CHCl2', 'OTMS'], 'products': ['OBn', 'Amphidinolides', 'G and H', 'OTMS']}], 'MeONHMe.HCI': [{'substrate': ['OBn'], 'products': ['1HCI in EtOH']}], 'iPrMgCI': [{'substrate': ['1HCI in EtOH'], 'products': ['MeO', 'OBn']}], 'DMSO,AcOH': [{'substrate': ['MeO', 'OBn'], 'products': ['AcO']}]} | |
8 | ['R-YLB10 mol-%', 'HO(30 mol-%).nBuLi(10 mol-%', 'OCOEt', '[2,6-CHOCgH3]3PO10mol-%)', 'CN', '62', 'THF.-78C.5h', '63', '92% yield,87% ee', '1.2,4-CICgH3', 'OCOEt', 'CN', '190C,6 h', 'OH', '64', '(+)-patulolideC'] | {'R-YLB': [{'substrate': ['HO', '[2,6-CHOCgH3]3PO', 'nBuLi'], 'products': ['OCOEt', 'CN', '62']}], 'nBuLi': [{'substrate': ['62'], 'products': ['THF.-78C.5h', '63']}], '[2,6-CHOCgH3]3PO': [{'substrate': ['63'], 'products': ['92% yield,87% ee', '1.2,4-CICgH3', 'OCOEt']}], 'CN': [{'substrate': ['1.2,4-CICgH3'], 'products': ['CN', '190C,6 h', 'OH', '64']}], 'OH': [{'substrate': ['64'], 'products': ['(+)-patulolideC']}]} | |
9 | ['[MCI4]2', '+MCInHO', '2-Propanol/HCI', '60 min,110', 'CI', 'M=Cu,Co,Mnx=0.25,0.50,0.75', 'Monometallic:M=Cu,Co.Mn', 'Ma1-/Mbx', 'Bimetallic:', 'Trimetallic:', 'M0.33/Mb0.33/M0.33'] | {'MCI4': [{'substrate': ['2-Propanol/HCI'], 'products': ['Monometallic:M=Cu,Co.Mn', 'Bimetallic:', 'Trimetallic:', 'M0.33/Mb0.33/M0.33']}]} | |
10 | ['NH3*', 'NH3*', 'HO', '+ 2H++ 2e', 'Serotonin', 'Tryptamine-4,5-dione'] | {'NH3*': [{'substrate': ['Serotonin'], 'products': ['Tryptamine-4,5-dione', 'HO']}], '+ 2H++ 2e': [{'substrate': ['Serotonin'], 'products': ['Tryptamine-4,5-dione', 'NH3*']}]} | |
11 | ['DOPA', 'L-Tyrosine', 'Tyrosine', 'Dihydroxyphenylalanine', 'Doapamine', 'hydroxylase', '(DOPA)', 'decarboxylase', '(DA)', 'Phenylethanolamine-N-', 'Dopamine -hydroxylase', 'Epinephrine (EP)', 'Norepinephrine (NE)', 'methyltransferase'] | {'Dopamine-β-hydroxylase': [{'substrate': ['DOPA', 'Dihydroxyphenylalanine', 'Doapamine'], 'products': ['Norepinephrine (NE)']}], 'Phenylethanolamine-N-methyltransferase': [{'substrate': ['Norepinephrine (NE)'], 'products': ['Epinephrine (EP)']}], 'DOPA decarboxylase': [{'substrate': ['L-Tyrosine', 'Tyrosine'], 'products': ['DOPA', 'Dihydroxyphenylalanine', 'Doapamine']}]} | |
12 | ['NH2', '-4H+,-4e', 'H', 'H', 'Histamine', '2-(1H-Imidazol-4-yl)acetonitrile'] | {'NH2': [{'substrate': ['Histamine'], 'products': ['2-(1H-Imidazol-4-yl)acetonitrile']}], '-4H+,-4e': [{'substrate': ['Histamine'], 'products': ['2-(1H-Imidazol-4-yl)acetonitrile']}]} | |
13 | ['HC', 'HC', 'CH', '+HO', '+ CHCOOH', 'H3', 'HC', 'CH3', 'CH3', 'ACh', 'Choline'] | {'Acetylcholine Esterase': [{'substrate': ['Acetylcholine'], 'products': ['Choline', 'Acetic Acid']}], 'Choline Oxidase': [{'substrate': ['Choline'], 'products': ['Acetic Acid']}]} | |
14 | ['a', 'UV light', 'NF', 'b)', ':m', 'UV light', 'peel off', 'm m', 'm m', 'MOF', 'monomer', 'photoinitiator', '0', 'mould', 'MOF', 'stand-alone', 'monomer', 'peel off', 'UV light'] | {'Postsynthetic polymerisation (PSP)': [{'substrate': ['UiO-66-NH2', 'methacrylic anhydride', 'butyl methacrylate (BMA)', 'phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide'], 'products': ['square shaped polymer']}]} | |
15 | ['a)', 'Toluene', 'NR', '60C/7d', 'O-Zr', 'R=H,Me,Ph', '(c', 'O-Zr', 'CuBr/DMF', 'RT/19h'] | {'Diels–Alder cycloaddition': [{'substrate': ['Toluene'], 'products': ['NR']}], 'Cu-catalysed azide-alkyne cycloaddition': [{'substrate': ['O-Zr', 'CuBr/DMF'], 'products': ['R=H,Me,Ph']}]} | |
16 | ['(q', 'a)', 'Zr', 'Zr', 'Zr', 'Zr', '9', 'cm"\'K)', '3.5', 'E=0.32eV', 'SOH', '2.8', 'In(T/S', '0.02M', '2.1', 'SH', 'HSO4', 'HOS', '1.4', '2.8', '3.0', '3.2', '3.4', 'Zr', 'Zr', 'Zr', 'Zr', '1000T/K'] | {'HSO4': [{'substrate': ['SH'], 'products': ['HOS']}]} | |
17 | ['a', 'Open', 'Closed', 'Heating', 'Cooling', 'Coil', 'Globule', 'PNIPAM-modified MOF', 'Thermoresponsive', 'ZrO4(OHcluster', 'Guest molecule', 'polymer', 'q', 'NH', 'NH2-HBDC', 'PNIPAM-NHS', '+', 'DMF', 'CHCI3', 'ZrCI4', '120C,24 h', '60C,48 h', 'UiO-66-NH2', 'UiO-66-PNIPAM'] | {'NH2-HBDC': [{'substrate': ['ZrO4(OHcluster'], 'products': ['UiO-66-NH2']}], 'PNIPAM-NHS': [{'substrate': ['UiO-66-NH2'], 'products': ['UiO-66-PNIPAM']}]} | |
18 | ['a', 'Nano-MOF', 'UiO-66-N.', '+', 'DBCO-DNA', 'MOF-DNA-Conjugate', '(q', 'ONA'] | {'SPAAC': [{'substrate': ['UiO-66-N3', 'DBCO-DNA'], 'products': ['MOF-DNA-Conjugate']}]} | |
19 | ['0.2 mol% cat', '1 atm CO2', 'nBu4NBr', '60h/25C', '~62%'] | {'FJI-H6(Cu)': [{'substrate': ['CO2', 'chloropropylene oxide'], 'products': ['cyclic carbonate']}]} | |
20 | ['a', 'NH2-bdc', 'HO/5days/85C', 'NH2', '76% exchange', 'Zr', 'T', 'TiCl4(THF)2', 'DMF /5days/85C', '38% exchange'] | {'NH2-bdc': [{'substrate': ['Br-bdc'], 'products': ['NH2-bdc']}], 'TiCl4(THF)2': [{'substrate': ['Zr'], 'products': ['Ti']}]} | |
21 | ['Zr', 'a)', 'Zr', '10', 'co', 'Co', 'UiO-66-[FeFe](dcbdt)(CO)6', '3-', 'umol', '2', '2', 'T', '30', '60', '06', '120', '150', 'Time/minutes', 'Background', '[FeFe](dcbdt)(CO)e', 'UiO-66', 'UiO-66-[FeFe](dcbdt)(CO)e'] | {'UiO-66-[FeFe](dcbdt)(CO)6': [{'substrate': ['CO'], 'products': ['H2']}]} | |
22 | ['DES (R2)4NX / HBD', 'R,COOH', 'R,COOR2', '2 h, 140C', 'R = alkyl, aryl', '42%-81%'] | {'DES (R2)4NX / HBD': [{'substrate': ['R,COOH', 'R = alkyl, aryl'], 'products': ['R,COOR2']}]} | |
23 | ['OH', 'OH', 'OH', 'Candida antarctica lipase', 'HO', 'OH', 'HO', 'OH'] | {'Candida antarctica lipase': [{'substrate': ['vinyl decanoate', 'choline:urea', 'choline:glucose'], 'products': ['glucose monodecanoate']}]} | |
24 | ['Et', 'OH', 'DES', 'N-Et', 'OH', 'Ultrasound', '0', 'anthracen-9-ylmethanol', '1-ethyl-1H-pyrrole-2,5-dione'] | {'DES': [{'substrate': ['N-ethylmaleimide', 'anthracen-9-ylmethanol'], 'products': ['1-ethyl-1H-pyrrole-2,5-dione', 'EtOH']}]} | |
25 | ['Ar', 'DES', 'R2OC', 'NH', 'H2N', 'NH2', 'R', 'X=O,s'] | {'Biginelli reaction': [{'substrate': ['aldehyde', 'ß-ketoester', 'urea'], 'products': ['3,4-dihydropyrimidin-2(1H)-one', 'thiones derivatives']}]} | |
26 | ['H', 'Choline chloride-based', 'COOH', 'CHO', 'DES', 'R-NC', 'R', '0'] | {'Passerini reaction': [{'substrate': ['benzaldehyde', 'benzoic acid', 'cyclohexyl isocyanide'], 'products': ['α-acyloxycarboxamide']}]} | |
27 | ['MT', 'OPP', 'OPP', 'SAM', 'MIBS', 'H', 'GPP', '2-Me-GPP', 'OPP', 'SodC', 'SAM', 'SodD', 'OPP', 'FPP', 'Lon22,DMAPP', 'OPP', 'R', 'IPP (R=H)', 'Lon23,SAM', 'dmGGPP', '(Z)-4-Me-IPP (R=Me)', 'OPP', 'SBS', '(2Z,6Z)-FPP', '5', '6'] | {'MIBS': [{'substrate': ['GPP', '2-Me-GPP'], 'products': ['1']}], 'SodC': [{'substrate': ['FPP'], 'products': ['2']}], 'SodD': [{'substrate': ['2'], 'products': ['3']}], 'Lon22': [{'substrate': ['DMAPP'], 'products': ['dmGGPP']}], 'Lon23': [{'substrate': ['IPP'], 'products': ['(Z)-4-Me-IPP']}], 'SBS': [{'substrate': ['(2Z,6Z)-FPP'], 'products': ['4', '5', '6']}]} | |
28 | ['1,2-H~', 'OPP', 'FPP', 'B2', 'HcS', 'a)1,6-cy', '1.6-H', '1,11-cy', '2-H', '(R)-NPP', 'D2', 'C2', 'b) 1,11-cy', '1,6-cy', "1,3-H'~", 'A1', 'B1', 'B)', 'BbS', '1,6-cy', 'OPP', 'FPP', '(R)-NPP', '(S)-A3', 'SmTS6', '1,10-cy', 'OPP', 'FPP', 'A4'] | {'HcS': [{'substrate': ['1,2-H~', 'OPP', 'FPP'], 'products': ['B2', '(1,6-H)', '(1,11-cy)']}], 'BbS': [{'substrate': ['(R)-NPP', 'D2', 'C2'], 'products': ['B1', '(1,6-cy)', '(1,3-H~)']}], 'SmTS6': [{'substrate': ['OPP', 'FPP'], 'products': ['A4', '(1,10-cy)']}]} | |
29 | ['OPP', 'PP', '10', '10', '11 (R = CH2)', '11', '12 (R = O)', 'OPP', '13', 'B)', 'n-BuLi', 'OTBDPS', '14', '15', 'PIFA', 'OTBDPS', 'OTBDPS', '16', '17', 'TBAF', 'OH', 'PBr3', '13', '(NBu4)3HP2O7', '18'] | {'BbS': [{'substrate': ['PP analogue 10'], 'products': ['acyclic products']}, {'substrate': ['PP analogue 11'], 'products': ['1,6-cyclisation']}, {'substrate': ['PP analogue 12'], 'products': ['1,6-cyclisation']}, {'substrate': ['PP analogue 13'], 'products': ['new reaction paths']}], 'SmTS6': [{'substrate': ['PP analogue 10'], 'products': ['acyclic products']}, {'substrate': ['PP analogue 11'], 'products': ['new reaction paths']}, {'substrate': ['PP analogue 12'], 'products': ['new reaction paths']}, {'substrate': ['PP analogue 13'], 'products': ['1,10-cyclisation']}], 'HcS': [{'substrate': ['PP analogue 11'], 'products': ['new reaction paths']}, {'substrate': ['PP analogue 12'], 'products': ['new reaction paths']}, {'substrate': ['PP analogue 13'], 'products': ['1,6-cyclisation or 1,11-cyclisation']}]} | |
30 | ['Compound 3', 'Compound 5', 'Compound 6', '0000', '0000', '0000', 'Oh', '1h', 'Y', '5h', 'Y', 'O.N.', 'Y', 'Oh', 'Y', '1h', 'Y', '5h', 'Y', 'O.N.', 'Oh', '1h', '5h', 'O.N.', 'Compound 7', 'Compound 8', 'Compound 9', '0000', '0000', '0000', 'Oh', '1h', '5h', 'O.N.', 'Oh', '1h', '5h', 'O.N.', 'Oh', '1h', '5h', 'O.N.', 'Compound 10', 'Compound 11', 'U', '0000', '0000', 'N+', 'Oh', '1h', '5h', 'O.N.', 'Oh', '1h', '5h', 'O.N.', 'OH', 'X', 'Compound 12', 'Compound 13', 'N+/OH', '0000', 'N+/C=C', '20H', 'HO', 'Oh', '1h', '5h', 'O.N.', 'Oh', '1h', '5h', 'O.N.'] | {'Hydroxylation': [{'substrate': ['Compound 3', 'Compound 5', 'Compound 6', 'Compound 7', 'Compound 8', 'Compound 9', 'Compound 10', 'Compound 11', 'Compound 12', 'Compound 13'], 'products': ['OH', '2OH']}]} | |
31 | ['(b)', '(a)', 'CHzOH (C)', '3-0 bile acid', 'Bile acid', 'HCO3->CH2O2->CH2O', 'PAH', 'CH3OH', 'NAD(H)', 'HSD', 'FDH', 'FaldDH', 'ADH', 'W', '0', 'NADH', 'CO2', 'W', 'Enzymes', 'NAD', 'NADH NAD', 'NADH NAD', 'NADH NAD', 'NAD(H)', 'GDH', 'DCPIP(blue', 'Reduced DCPIP', '(colorless)', 'a-ketoglutaric acid', 'Glutamic acid'] | {'3α-hydroxysteroid dehydrogenase (HSD)': [{'substrate': ['Bile acid'], 'products': ['3-0 bile acid']}], 'Diaphorase (DP)': [{'substrate': ['HCO3->CH2O2->CH2O'], 'products': ['CHzOH (C)']}], 'FaldDH': [{'substrate': ['NADH NAD'], 'products': ['NADH NAD']}], 'ADH': [{'substrate': ['NADH NAD'], 'products': ['NADH NAD']}], 'GDH': [{'substrate': ['NADH NAD'], 'products': ['NADH NAD']}], 'DCPIP': [{'substrate': ['Reduced DCPIP (colorless)'], 'products': ['DCPIP(blue)']}], 'FDH': [{'substrate': ['a-ketoglutaric acid'], 'products': ['Glutamic acid']}]} | |
32 | ['Inner Channel', '(a)', '(b)', 'PVP', 'CoAc):PVP', '2000', 'BP-Co,O-NTs', 'Outer Channel', '0.27:1', 'CoAc', 'AP-CoO-NTs', '(mAh', '600', 'PVP', 'Co(Ac) : PVP', 'AP-CoO-NTs', 'Calcining', '0.54 :1', '1200', 'CP-Co,O-NTs', 'BP-Co,O,-NTs', '800', '0.3 A g-1', 'High', 'Voltage', 'Co(Ac) : PVP', '0.67:1', '00', 'Nu', '0', '20', '40', '60', '80', '100', 'CP-CoO-NTs', 'Cycle number'] | {'PHBH': [{'substrate': ['NADPH', 'FAD', 'COC', 'R', 'HO'], 'products': ['FADHOOH', 'H2O', 'COO', 'NF', 'COO', 'OH', 'COO', 'HO', 'OH', 'V', 'HO', 'HO', 'OH']}]} | |
33 | ['(b)', '(a)', '(c)', 'SAN', 'Burnt out SAN:pores & hollowness', 'Thermal', 'processes', 'PAN', 'Carbonized PAN', '1n', '100nm', '(d)', '250', '600', 'H2/N2', 'H2/N2', 'HCI', '(f', 'Ni(Ac)2', 'Oil=', 'PAN/PVP Composite', 'Ni', 'Amorphous Carbon', 'O Hollow Graphitic Carbon Nanosphere', '100nm', '00nm', 'O Ni Encapsulated in Graphitic Carbon Nanosphere'] | {'Thermal Processes': [{'substrate': ['SAN', 'PAN'], 'products': ['Burnt out SAN:pores & hollowness', 'Carbonized PAN']}], 'H2/N2': [{'substrate': ['PAN/PVP Composite'], 'products': ['Amorphous Carbon']}], 'HCI': [{'substrate': ['Ni', 'Amorphous Carbon'], 'products': ['O Hollow Graphitic Carbon Nanosphere']}], 'Ni(Ac)2': [{'substrate': ['Oil='], 'products': ['O Ni Encapsulated in Graphitic Carbon Nanosphere']}]} | |
34 | ['lithiation', 'lithiation', 'delithiation', 'many cycles', '(a)', '(c)', '200nm', 'GeOx@C core-shell fiber', 'd)', 'GeOx', 'Li4.4Ge', 'Li2O', 'Carbon shell', 'SEI', '(b)', '1400', 'GeOx@C', '1200', '--charge', 'Specific capacity (mAh', '1000', '80mA/g', '--discharge', '320mA/g', '800', '800mAg', '600', '1600mA/g', '400', '4800mA/g', '200', '8000mA/g', '0', '0.5m', '0', '20', '40', '60', '80', '200', '300', '400', '500', 'Cycle number'] | {'Lithiation': [{'substrate': ['Li4.4Ge', 'Li2O'], 'products': ['GeOx']}], 'Delithiation': [{'substrate': ['GeOx'], 'products': ['Li4.4Ge', 'Li2O']}]} | |
35 | ['(b) 7', '(a)', 'Specific activity, [U mg-"]', '3.0', '-MES', 'Specific activity, [U mg"]', 'TRIS', '6', '2.5', 'HEPES', 'Carbonate', '2.0', '1.5', '1.0', '2', '0.5', '0.0', '5', '6', '7', '8', '9', '10', '11', '20 30 40 50 60 70 80', 'pH-value, []', "Temperature, ['C]"] | {'TR/Trx1': [{'substrate': ['DTT', 'NADP+'], 'products': ['TR', 'Trx1']}]} | |
36 | ['(a)', '30', 'Yield [%]', 'Selectivity [%]', ' 100', '120', 'c(1-PEA) [mM]', '25', '80', ' 100', 'c(1-PEA) [mM]', '20', '-80', '60', '15', '-60', '40', '10', '40', '20', '5.', '-20', '0', '0', '3', '8', '24', 'Time [h]', '(b)', '12', 'Yield [%]', 'Selectivity [%]', '100', '- 120', 'c(ECL)[mM]', '10', '80', ' 100', 'c(ECL) [mM]', '8', '80', '60', '6', '-60', '40', '4', '40', '2.', '20', '- 20', '0', '0', '-0', '3', '5', '8', '24', 'Time [h]'] | {'TR/Trx1': [{'substrate': ['ACP', 'DTT', 'CHO'], 'products': ['1-PEA', 'ECL']}], 'ADH': [{'substrate': ['ACP'], 'products': ['1-PEA']}], 'CHMO': [{'substrate': ['CHO'], 'products': ['ECL']}]} | |
37 | ['cathode', 'MV2+', 'MV+', 'E. coli', 'periplasm', 'MV2+', 'MV+', 'MtrA', 'STC', 'CymA', 'i2e"', '2e', 'cytoplasm', 'NADP++H+', 'NADPH', 'LbADH', 'HO', 'acetophenone', '(R)-1-phenylethanol'] | {'LbADH': [{'substrate': ['acetophenone'], 'products': ['(R)-1-phenylethanol']}], 'MtrA': [{'substrate': ['MV2+'], 'products': ['MV+']}], 'STC': [{'substrate': ['MV2+'], 'products': ['MV+']}], 'CymA': [{'substrate': ['MV2+'], 'products': ['MV+']}]} | |
38 | ['HO', '17', '12', '18', 'furanoflavonols', '19', 'furanoisoflavones', 'OH', '.', 'OH', 'm', '11', 'furanochalcones', '8', 'OEt', 'OH', '10', 'OH', 'R', 'furanocoumarins', 'OH', '2', '3', 'OH', '6', 'OF', 'H2N', '16', '15', '14', 'furanoisoquinolinones', 'furanoflavones'] | {'KOH': [{'substrate': ['ethyl 2-chloroacetoacetate', 'H2O/MeOH (6:1)'], 'products': ['≈65\u2009%']}, {'substrate': ['H2O/MeOH (1:2.5)'], 'products': ['>90\u2009%']}], 'Cu': [{'substrate': ['pyridine', 'DEG'], 'products': ['≈85\u2009%']}], 'NaH': [{'substrate': ['ethyl formate', 'PhMe'], 'products': ['10\u2005h']}, {'substrate': ['ethyl acetate', 'DME'], 'products': ['4.5\u2005h']}, {'substrate': ['dimethyl carbonate', 'DME'], 'products': ['4.5\u2005h']}], 'DDQ': [{'substrate': ['PhMe'], 'products': ['≈75\u2009% (d+g)', '≈70\u2009% (e+h)', '≈75\u2009% (f+i)']}], 'DMF-DMA': [{'substrate': ['DMF'], 'products': ['99\u2009%']}], 'I2': [{'substrate': ['CHCl3'], 'products': ['90\u2009%']}], 'arylboronic acid': [{'substrate': ['Na2CO3', 'Pd(OAc)2', 'PEG\u200510\u2009000', 'MeOH'], 'products': ['50\u2009°C', '4\u2005h']}], 'benzaldehyde': [{'substrate': ['NaH', 'THF'], 'products': ['RT', '2\u2005h']}, {'substrate': ['piperidine', 'PhMe'], 'products': ['120\u2009°C', '3\u2005h']}, {'substrate': ['piperidine', 'PhMe'], 'products': ['120\u2009°C', '12\u2005h']}], 'NaOH': [{'substrate': ['30\u2009% aq H2O2', 'THF/MeOH (3:5)'], 'products': ['0\u2009°C–RT', '48\u2005h']}], 'reactive methylene compound': [{'substrate': ['piperidine', 'EtOH'], 'products': ['80\u2009°C', '4\u2005h']}], 'DMSO': [{'substrate': ['NaH', 'PhMe'], 'products': ['80\u2009°C', '2\u2005h', '95\u2009%']}], 'MeOH': [{'substrate': ['NH3'], 'products': ['65\u2009°C', '24\u2005h', '100\u2009%']}]} | |
39 | ['GOase', 'KRED119', '1a', 'OH', 'HO', '1c', '30C,3h', '30C,24 h', 'M-1b 50%', '(P)-1b 67%', '99% ', '89% '] | {'GOase': [{'substrate': ['1a', 'OH'], 'products': ['HO', '1c']}], 'KRED119': [{'substrate': ['1c'], 'products': ['M-1b', '(P)-1b']}]} | |
40 | ['Me', 'OMe', 'OMe', 'Kfast', 'Kelow', 'M-5b', 'B', 'GOase M35', 'GOase M35', 'OMe', 'C', 'Kslow', '5a', 'B', 'Atast', '5c', 'HO', 'P)-5b'] | {'GOase M35': [{'substrate': ['M-5b', 'B'], 'products': ['5a', 'B']}, {'substrate': ['5a', 'B'], 'products': ['5c', 'HO']}], 'Kfast': [{'substrate': ['5c', 'HO'], 'products': ['P)-5b']}], 'Kslow': [{'substrate': ['P)-5b'], 'products': ['Me', 'OMe']}]} | |
41 | ['100', '90', '-ee of 5b', '80', '70', '5a', '60', '% 50', '5b', '40', '-5c', '30', '20', '10', '0', '0', '50', '100', '150', '200', '250', '300', '350', '400', 'time/min'] | {'GOase M3-5': [{'substrate': ['5a'], 'products': ['5b', '5c']}]} | |
42 | ['Ru-BINAP', 'OH', 'H2', 'n=1:4', 'n =2: 5', 'OH', '2. NaCIO2', 'n=1:6', 'methyl-2-butene', 'n = 2: 7', 'R-OH', 'EDC', 'n = 1: 8a', 'n = 2: 9a', 'n =1: 8', 'n = 2: 9', 'I:R=', 'f: R', 'i:R =', 'n:R', 'j: R ='] | {'Ru-BINAP': [{'substrate': ['OH', 'H2'], 'products': ['n=1:4', 'n=2:5']}], 'NaCIO2': [{'substrate': ['OH'], 'products': ['n=1:6']}], 'EDC': [{'substrate': ['methyl-2-butene', 'n=2:7', 'R-OH'], 'products': ['n=1:8a', 'n=2:9a']}, {'substrate': ['n=1:8', 'n=2:9', 'I:R=', 'f:R', 'i:R=', 'n:R', 'j:R='], 'products': ['n=1:8a', 'n=2:9a']}]} | |
43 | ['hydrolysis', 'elimination', 'hydrogenation', 'phosphatase', 'oxidation', 'GPP', 'FPP', '8a', 'GGPP', '53', '9a', 'GFPP', '58', '14a', 'FFPP', '3', '30', '15a', '28', 'GGFPP', 'OH', '63'] | {'Hydrolysis': [{'substrate': ['GPP', 'FPP', 'GGPP', 'GFPP', 'FFPP', 'GGFPP'], 'products': ['53', '9a', '58', '14a', '3', '30', '15a', '28', 'OH', '63']}], 'Elimination': [{'substrate': ['GPP', 'FPP', 'GGPP', 'GFPP', 'FFPP', 'GGFPP'], 'products': ['α- and β-terpene hydrocarbons']}], 'Hydrogenation': [{'substrate': ['4', '8a'], 'products': ['15a']}], 'Phosphatase': [{'substrate': ['4'], 'products': ['OH']}], 'Oxidation': [{'substrate': ['4', '8a'], 'products': ['15a']}]} | |
44 | ['HRP', 'A', 'IH', 'Hi', 'ECM', 'HN', 'NH', 'N', 'HRP', 'Streptavidin', 'Biotin', 'HRP Horseradish', 'Peroxidase', 'B', '250', '***', '*', '200', 'Rel. Absorbance [%]', '150', '100', '50', '8888', '0', 'CoECM', 'BeocECM', 'PeocECM', 'HeocECM', 'CpECM'] | {'HRP': [{'substrate': ['Biotin'], 'products': ['TMB']}], 'Streptavidin': [{'substrate': ['HRP'], 'products': ['HRP-linked streptavidin']}]} | |
45 | ['B', 'A', 'Microscale', 'reaction mixture in DMSO', 'Bound', 'Coupling', 'FR1-FR2', 'reagents', 'FR1', 'FR1', 'FR2', 'Enzyme', 'preincubation', 'Enzyme', 'FR2', 'ENZYME', 'NO EFFECT', 'INHIBITION', '100', '100', '% of Inhibition', '% of Inhibition', 'FR1-FR2', '-', 'I Activity', 'FR1 FR2', 'FR1', 'FR2', 'i bound', '-', 'unbound', '50', 'Window of I', '50', 'shift', 'test', '-', "concentration'", '-', '-', '-', 'nM', 'M', 'mM', 'M', 'nM', 'M', 'mM', 'M', 'Log Dose', 'Log Dose', 'FR1', 'Fragment 1; FR2', 'Fragment 2;', 'and', 'coupling reagents'] | {'FXIIa': [{'substrate': ['FR1', 'FR2'], 'products': ['FR1-FR2']}], 'Thrombin': [{'substrate': ['FR1', 'FR2'], 'products': ['FR1-FR2']}]} | |
46 | ['EDCI,DMAP', 'DMSO-d6', '8', '13a', 'A', 'Microscale reaction mixture(H NMR', 'DMAP', 'EDCI/EDU', 'DMAP', 'EDU', 'Water', '9.0', '8.5', '8.0', '7.5', '7.0', '6.5', '6.0', '5.5', '5.0', '4.5', '4.0', '3.5', '3.0', '2.5', '2.0', '1.5', '1.0', '0.5', '0.0', '-', 'ppm', 'B', '-', '13a', '13a', '13a', '1.00 1.81', '1.96', '8.9', '88', '8.7', '8.6', '8.5', '8.4', '8.3', '8.2', '8.1', '8.0', '7.9', '7.8', '7.7', '7.6', '7.5', '7.4', '7.3', 'c', 'ppm', '13a', '8.9', '8.8', '8.7', '8.6', '8.5', '8.4', '8.3', '8.2', '8.1', '8.0', '7.9', '7.8', '7.7', '7.6', '7.5', '7.4', '7.3', 'ppm'] | {'EDCI/DMAP': [{'substrate': ['Aminotriazole 7'], 'products': ['13a']}]} | |
47 | ['Ar-I (3 equiv.), AgOAc (2 equiv.)', 'AQ', 'Pd(OAc)2 (5 mol-%), no solvent', '110C,24 h', '0.50 mmol', '.', '2', 'OMe', 'C', '2a', '2b', '2c', '2d', '78%(rac)', '83%', '78%', '81%', '86% (88% ee)'] | {'Pd(OAc)2': [{'substrate': ['Ar-I', 'AgOAc'], 'products': ['2a', '2b', '2c', '2d']}]} | |
48 | ['Ar-I3 equiv.),AgCO1 equiv.)', 'AQ', 'PivOH (0.3 equiv.),Pd(OAc)2(10 mol-%)', 'Boc', 'toluene (0.3 M,110C,72 h', 'Boc', '5', 'scale:0.50 mmol', '6', 'OMe', 'CI', 'CI', 'Boc', 'Boc', 'Boc', 'O', 'Boc', 'O', '6a', '6b', '6c', '6d', '53% (>98% ee)', '59%', '41%', '38%', 'ent-6a 52%'] | {'AgCO1': [{'substrate': ['Ar-I3', 'PivOH'], 'products': ['6a', '6b', '6c', '6d']}], 'Pd(OAc)2': [{'substrate': ['Boc-5', 'toluene'], 'products': ['6a', '6b', '6c', '6d']}]} | |
49 | ['Ar-I (3 equiv.),AgCO1 equiv.)', 'AQF', 'PivOH (30 mol-%), Pd(OAc)2 (5 mol-%)', 'AQ', 'N', 'no solvent,110 C,24 h', 'Boc', 'N', 'Boc', '9', '10', 'OMe', 'AQ', 'AQ', 'AQ', 'AQ', 'Boc', 'Boc', 'N', 'Boc', 'Boc', '10a', '10b', '10c', '10d', '78%', '82% (83% 2.8 mmol)[a]', '89%', '52%', 'CN', 'cOMe', 'OEt', 'AQ', 'AQ', 'AC', 'AQ', 'Boc', 'Boc', 'Boc', 'Boc', '10e', '10f', '10g', '10h', '46%', '64%', '66%', '73%'] | {'Ar-I': [{'substrate': ['N-Boc-piperidinecarboxamide 9'], 'products': ['10a', '10b', '10c', '10d', '10e', '10f', '10g', '10h']}], 'AgCO3': [{'substrate': ['N-Boc-piperidinecarboxamide 9'], 'products': ['10a', '10b', '10c', '10d', '10e', '10f', '10g', '10h']}], 'PivOH': [{'substrate': ['N-Boc-piperidinecarboxamide 9'], 'products': ['10a', '10b', '10c', '10d', '10e', '10f', '10g', '10h']}], 'Pd(OAc)2': [{'substrate': ['N-Boc-piperidinecarboxamide 9'], 'products': ['10a', '10b', '10c', '10d', '10e', '10f', '10g', '10h']}]} | |
50 | ['SMe', '14a', '15a', '16a', 'combined yield:', '78%', '68%', '<5%', 'dr:', '83:17', '80:20', 'oreferred conditions:', 'AgCO3,PivOH', 'Ag2CO3,PivOH', 'Pd(OAc)2', 'Pd(OAc)2', 'tert-amyl-OH (0.2 M)', 'tert-amyl-OH (0.5 M)'] | {'AgCO3': [{'substrate': ['SMe', '14a', '15a', '16a'], 'products': ['14a', '15a', '16a']}], 'Ag2CO3': [{'substrate': ['SMe', '14a', '15a', '16a'], 'products': ['14a', '15a', '16a']}], 'Pd(OAc)2': [{'substrate': ['SMe', '14a', '15a', '16a'], 'products': ['14a', '15a', '16a']}], 'tert-amyl-OH': [{'substrate': ['SMe', '14a', '15a', '16a'], 'products': ['14a', '15a', '16a']}]} | |
51 | ['I3 equiv.),Ag2CO31 equiv.)', 'Ar', 'Pd(OAc)2 (5 mol-%),', 'AQ', 'tert-amyl-OH (0.2 M)', '.', '110C,24h', '13', '14', 'scale: 0.50 mmol', 'OMe', 'CI', 'AQ', 'AQ', 'AQ', 'AQ', '14a', '14b', '14c', '14d', '90%', '92%', '78%', '67%', 'dr 80:20', 'dr 83:17', 'dr 82:18', 'dr.72:28'] | {'Pd(OAc)2': [{'substrate': ['I3', 'Ar', 'tert-amyl-OH'], 'products': ['13', '14']}], 'Ag2CO3': [{'substrate': ['OMe', 'CI'], 'products': ['14a', '14b', '14c', '14d']}]} | |
52 | ['a)', 'pTolSCI', '22(0.9 equiv', '230.8 equiv)', 'pTolSCI', '(1 equiv)', 'TTBP1 equiv', 'TTBP (1 equiv)', '0.9 equiv)', '71% yield', '211 equiv', 'A', 'Y', 'Y', 'A', 'for the three', 'AgOTf (4 equiv', '5 min120min', '15 min5 min120 min', 'step one', '-78', '-10', '-78', '-10', 'pot reactions', 'b)', 'pTolSCI', '170.9 equiv', '280.8 equiv', 'pTolSCI', '1 equiv)', 'TTBP1 equiv', 'TTBP(1 equiv', '(0.9 equiv)', '50% yield', '271 equiv', 'Y', 'for the three', 'AgOTf (4 equiv)', '26', '5min|120 min15 min5min120 minl', 'step one', '-78', '-10', '-78', '-10', 'pot reactions', 'OBn', 'OLev', 'OLev', 'OBn', 'OBn', 'O', 'OBn', 'OBn', 'OLev', 'TBSO', 'N3', 'BnO', 'N3', 'BnO', 'Nal', 'BnO', 'BzO', 'OBn', 'BzO', '26', 'OEt', 'OLev', 'OBn', 'OLev', 'BzO', 'OBn', 'OBn STol', 'O', 'OBn OEt', 'TBSO', 'N3', 'OH', 'N', 'BnO', 'BnO', '27', 'BzO', '28', 'BzO'] | {'pTolSCI': [{'substrate': ['TTBP', 'TTBP'], 'products': ['OLev', 'OBn']}, {'substrate': ['TTBP'], 'products': ['OLev', 'OBn']}], 'AgOTf': [{'substrate': ['OLev', 'OBn'], 'products': ['TBSO', 'N3']}, {'substrate': ['OLev'], 'products': ['BnO', 'Nal']}], 'OEt': [{'substrate': ['BzO'], 'products': ['OBn', 'STol']}], 'OH': [{'substrate': ['BnO'], 'products': ['BzO', 'OEt']}]} | |
53 | ['OH', 'OH', 'L-threonine', 'CO2H', 'aldolase', 'NH2', 'KPi pH 8.0', '2S)-syn-3', '(2S)-anti-3', '200 M PLP', 'OH', 'R1', 'NH2', 'D-threonine', '1', '2', 'aldolase', 'OH', 'HO', 'COH', 'CO2H', 'KPi pH 8.0', 'R', 'NH2', "'NH2", '200M PLP', 'R2', 'R2', '(2R)-syn-3', '(2R)-anti-3'] | {'L-threonine aldolase from Aeromonas jandaei': [{'substrate': ['L-threonine', 'R1'], 'products': ['OH', '(2S)-syn-3', '(2S)-anti-3']}], 'D-threonine aldolase from Pseudomonas sp.': [{'substrate': ['D-threonine', 'R2'], 'products': ['OH', '(2R)-syn-3', '(2R)-anti-3']}]} | |
54 | ['OF', 'C', 'HO', 'OH', 'Glc-1P', 'deoxy-fluoro-D-glucoses 2F-Glc,3F-Glc or 6F-Glc)', 'HEPES', 'CBP', 'pH 7.2', '37', 'B', 'OH', 'OH', 'HO', 'CDP', 'HC', 'HPO42', 'HO', 'HO', 'OH', 'HEPES', 'HO', 'OF', '2F-cellobiose (1)', 'pH 7.2', 'Glc-1P', '37', '2F-EpC (4)', '3F-cellobiose (2)', '3F-EpC (5)', '6F-cellobiose (3)', '6F-EpC6)', '.', 'OH', 'CDP', 'HPO42', 'HO', 'HO', 'OH', 'NaOAc', 'HO', 'HO', 'OH', 'pH5', 'R=F (6F-GIc-1P)', 'cellobiose', '37', 'R =F (multi-6F-EpC, 7)', 'R=OHG|c-1P', 'R=OHEpC,8'] | {'Cellobiose Phosphorylase (CBP)': [{'substrate': ['Glc-1P', '2F-Glc', '3F-Glc', '6F-Glc'], 'products': ['2F-cellobiose (1)', '3F-cellobiose (2)', '6F-cellobiose (3)']}], 'Cellodextrin Phosphorylase (CDP)': [{'substrate': ['2F-cellobiose (1)', '3F-cellobiose (2)', '6F-cellobiose (3)'], 'products': ['2F-EpC (4)', '3F-EpC (5)', '6F-EpC (6)']}, {'substrate': ['6F-Glc-1P', 'Cellobiose'], 'products': ['multi-6F-EpC (7)', 'EpC (8)']}]} | |
55 | ['b)', 'a)', '.', 'Cu/SmO@AIO1.5', '65', '4.0', ' Cu/YO@AIOz(1.5)', 'CO/CO molar ratio in products (-)', ' Cu/ScO@AIO1.5', '60', '3.5', 'Cu/ZrO@AIO1.5', 'selectivity (%)', 'Cu/AIO1.5', '55', '3.0', 'Cu/TaO@AIO1.5', 'Cu/TaO@AIO3.0', '50', '2.5', 'V Cu/TaO@AIO(4.5)', '45', 'Methanol', '2.0', '40', '1.5', '35', '1.0', '30-', '0.5', '25', '2.36', '2.40', '2.44', '2.36', '2.40', '2.44', '2.48', '2.52', '2.56', '2.48', '2.52', '2.56', 'Oxide Lewis acidity,neV)', 'Oxide Lewis acidity, n (eV)'] | {'Cu/MOx@Al2O3': [{'substrate': ['propylene carbonate'], 'products': ['methanol', 'CO', 'CO2']}]} | |
56 | ['Mg(NO)2-6HO', '2,5-dioxidoterephthalate(DOT)', 'solvent exchange', 'activation', 'Mg-MOF-74-DMF', 'Mg-MOF-74'] | {'Mg(NO3)2-6H2O': [{'substrate': ['2,5-dihydroxyterephthalate(DOT)'], 'products': ['Mg-MOF-74']}]} | |
57 | ['SpAS1 H103X', 'A)', 'B)', '5', 'C', '4', 'H', 'Iog[K./K (s" M\')] sulfate 4', 'log[Kk/K (s M)] sulfate 4', "log[K/K (s M')] sulfate 4", '3', '0.', '3', 'M', 'S', '3', 'Q', 'HO', '2', '2', '2', 'DO', 'E', '1', 'N', 'N', '1', 'W', 'KO', 'ne', '1', '2', '-2', '2', '-2', '-1', '0', '1', '2', '3', '5', '-2', '-1', '0', '1', '2', '4', '5', '2', '-1', '0', '1', '2', '4', '5', "og[kKsM'] phosphate 1", 'log[kKsM] phosphate 2b', 'log[k/KsM] phosphonate 3a', 'R/PMH T107X', 'D)', '5', 'E', '5', 'F)', '5', '4', '4', 'Y F', 'LM', 'G', '3', 'IO', 'LV', 'YF', '3', 'N', 'G', 'W', '2', 'WO', '2', 'QO', 'OOWR', '2', '1', '1', '1', '1', '1', '2', '2', '2', '2', '-2', '-1', '0', '4', '5', '-2', '-1', '0', '3', '4', '5', '-2', '-1', '0', '1', '2', '3', '4', '5', "log[k/KsM'] phosphate 1", 'log[k/KsM] phosphate 2b', 'loa[kKsMsulfate4'] | {'SpAS1 H103X': [{'substrate': ['sulfate 4'], 'products': ['phosphate 1', 'phosphate 2b', 'phosphonate 3a']}], 'RlPMH T107X': [{'substrate': ['phosphate 1', 'phosphate 2b'], 'products': ['sulfate 4']}]} | |
58 | ['2.510', '2.0x10-3', '1.510-3', 'obs', '1.010-3', '5.01', '0.0-', '0.00', '0.01', '0.02', '0.03', '0.04', '[nCuO]/mg/mL'] | {'RhCl3*3 H2O': [{'substrate': ['1.)EtO(CH)OH/HO(3:1)', '2.)AgPF6.CH3CN', 'tBu', 'tBu', 'Me', 'Me', 'Bu', 'rac-Rhind', 'KCO3.EtOH,70C,6 h', 'h', '(S)-2', 'tBu', 'tBu', 'Bu', 'tB', '-(S)-3', '-(S)-4'], 'products': ['-(S)-3', '-(S)-4', 'A-RhInd', '-RhInd']}]} | |
59 | ['3.210', '3.010-3', '2.810-3', ' 2.6x10-3', 'bs', '2.410', '2.210-3', '2.010-3', '1.810-3', '0', '10', '20', '30', '40', '50', '60', 'Delay time/min'] | {'CuO nanoparticles': [{'substrate': ['CblNO2', 'Asc'], 'products': ['CblNO']}]} | |
60 | ['a)', 'b)', '7.0104', '8.5104', '6.8104', '8.0104', '6.6104', ' 7.510-4', 'obs', 'sqo', '6.410', '7.0104', '6.2x10-4', '6.5104', '6.0104', '6.0104', '0', '10', '20', '30', '40', '50', '0', '10', '20', '30', '40', '50', 'Delay time / min', 'Delay time / min'] | {'Fe3O4': [{'substrate': ['CblNO2', 'Asc'], 'products': ['CblNO']}], 'Fe3O4 (with stabilizer)': [{'substrate': ['CblNO2', 'Asc'], 'products': ['CblNO']}], 'CuO': [{'substrate': ['CblNO2', 'Asc'], 'products': ['CblNO']}]} | |
61 | ['MWCNT-PDA/GO Mixture Solution', 'MWCNT-PDA/GO', 'Hybrid Aerogel', 'HydrothermalProcess', 'Freeze-drying Process', 'MWCNT-PDA/GO Hybrid Hydrogel', 'HOOC', 'Complexation', 'OH', 'COOH', 'HOOC', 'OH', ':CuII', '0', 'COOH', ':PbII', 'HO', 'Chelation', 'OOH', 'HOOC', 'NH2', 'COOH', 'Hal', 'OH', 'HO', 'OH', 'C=O', 'HOOC', 'COOH', 'HOO', 'HOOC', 'oon', 'HQ', 'HOOC'] | {'MWCNT-PDA/GO Mixture Solution': [], 'MWCNT-PDA/GO Hybrid Aerogel': [], 'Hydrothermal Process': [], 'Freeze-drying Process': [], 'MWCNT-PDA/GO Hybrid Hydrogel': [], 'Complexation': [{'substrate': ['Cu2+'], 'products': ['COOH']}, {'substrate': ['Pb2+'], 'products': ['HO']}], 'Chelation': [{'substrate': ['Cu2+', 'OH'], 'products': ['HOOC']}, {'substrate': ['Pb2+', 'NH2'], 'products': ['COOH']}]} | |
62 | ['TsO', 'a', '18', '[18F]2'] | {'K[18F]F': [{'substrate': ['2-azidoethyl 4-methylbenzenesulfonate'], 'products': ['[18F]-1-azido-2-fluoroethane']}], 'CuSO4': [{'substrate': ['[18F]-1-azido-2-fluoroethane', 'alkyne precursor 18'], 'products': ['[18F]-2']}]} | |
63 | ['Starting material', 'Alkylating agent', 'Product', 'By-product', '(leaving group)', 'prenyl', 'O-P-O-P-OH', 'transferase', '0-P-O-P-OH', 'o', 'o', 'o', 'Prenyl diphosphate', 'Diphosphate', 'NH2', 'methyl', 'HOOC', 'transferase', 'NH2', 'NH', 'HO OH', 'HO OH', 'S-adenosyl-L-methionine', 'S-adenosyl-L-homocysteine', 'OH', 'NH', 'glycosyl', 'COOH', 'HO', 'transferase', 'OF', 'COOH', 'OH', 'HO', 'OH', 'OH', '+', 'HO', 'HO', 'HO OH', 'HO OH', 'Uridine diphosphate glucose', 'Uridine diphosphate'] | {'Prenyltransferase': [{'substrate': ['Prenyl diphosphate', 'Diphosphate'], 'products': ['Starting material', 'Alkylating agent', '(leaving group)']}], 'Methyltransferase': [{'substrate': ['S-adenosyl-L-methionine', 'NH2'], 'products': ['S-adenosyl-L-homocysteine', 'NH', 'HOOC']}], 'Glycosyltransferase': [{'substrate': ['Uridine diphosphate glucose', 'COOH'], 'products': ['COOH', 'OH', 'HO', 'OH', 'OH', '+', 'HO', 'HO', 'HO OH', 'HO OH']}]} | |
64 | ['a)Proposedmechanism for photoenzymatic radical hydroalkylation', 'Glucose', 'Gluconolactone', 'GDF', 'NADPH', 'NADP*', 'FMN', 'FMN', 'Product', 'Substrates', 'HN', 'FMNso', 'FMNno', 'iit', 'yan LED', 'FMNs', 'b)Intramolecular radical hydroalkylation(reductive cyclization)', 'd) Proposed mechanism for redox neutral radical substitution', 'X', 'ERED', 'up to: 98% yield', '>98% e.e.', 'Me', 'hv', 'Me', '84% d.e.', 'FMN', 'R', 'FMN', 'Me', 'Cyan LED', 'ERED', 'up to: 97%yield', '94% e.e.', 'FMN', 'FMNsq', 'hv', 'R', 'tricine', "tricine'", 'FMN', 'FMN', 'c)Intermolecular radical hydroalkylation', 'ERED', 'R4', 'up to: 99% yield', 'R', '99% e.e.', 'Me', 'Me', 'R3', 'hv', 'R2', 'R3', 'e)Intramolecular radical alkylation of aromatic compounds', 'R2', '..', 'R1LCI', 'R1R2', 'R1', 'ERED', 'R1', 'R4', 'up to: 99% yield', 'ERED', 'N', 'up to:', '97% yield', '1', '>98% e..', 'hv', 'hy', 'R3', '96% e.e.', 'R2', 'CI', 'R3', 'R2', 'R3', 'Me', 'Me'] | {'ERED': [{'substrate': ['Glucose', 'Gluconolactone', 'GDF', 'NADPH', 'NADP*', 'FMN', 'X', 'Me', 'R', 'tricine', "tricine'", 'R4', 'R3', 'R2', 'R1LCI', 'R1R2', 'R1', 'N'], 'products': ['FMN', 'FMNso', 'FMNno', 'Product', 'FMNs', 'FMNsq', 'FMN', 'Me', 'R3', 'R2', 'R1', 'R4']}]} | |
65 | ['a Biocatalytic alkylation with sulfonium intermediates', 'c)Stereoselective methylation reactions', 'MT', 'NuH', 'Nu-R', 'COOH', 'Me', 'MT', 'Mel', 'COOH', 'HMT', 'R', 'NH', 'up to 98% e.e.', '+NH', 'HO OH', 'HO OH', 'NHR2', 'Me', 'SAM-analog', 'SAH', 'MT', 'R10', 'sulfonium intermediate', 'Mel', 'NR', 'HMT', 'H', 'HMT', 'up to 84% yield', '> 99% e.e.', 'X', 'R-X', 'b)Regioselective methylation reactions', 'dRegioselective alkylation reactions', 'OH', 'OH', 'HO', 'OH', 'HO', 'OH', 'MT', 'OH', 'MT', 'Mel', 'HO', 'OH', 'HMT', 'HO', "'OH", 'OHC', 'HMTa', 'OF', 'OHC', 'OH', 'OH', 'Me', '>90%conv.', 'up to 48% conv.', 'Me', 'HO', 'OH', 'R', 'Mel', 'MT', 'HO', 'OH', 'MTa', 'R-X', 'HMT', 'NF', 'HMT', '>90% conv', 'R:Me,Et,Pr', 'up to 62% yield', 'up to 99:1 r.r.', 'regiodivergent'] | {'Halide Methyl Transferase (HMT)': [{'substrate': ['S-adenosyl-l-homocysteine (SAH)', 'Haloalkanes'], 'products': ['S-adenosyl-l-methionine (SAM) analogs', 'Halide']}], 'Methyltransferase (MT)': [{'substrate': ['S-adenosyl-l-methionine (SAM) analogs', 'Proteins', 'DNA', 'Small molecules'], 'products': ['S-adenosyl-l-homocysteine (SAH)', 'Methylated proteins', 'Methylated DNA', 'Methylated small molecules']}, {'substrate': ['S-adenosyl-l-methionine (SAM) analogs', 'Catechols', 'α-Keto acids', 'Amino-methylation of indoles', 'Pyrazoles'], 'products': ['Ethylated catechols', 'Allylated catechols', 'Stereoselective methylation of α-keto acids', 'Amino-methylation of indoles', 'Alkylated pyrazoles']}]} | |
66 | ['a Chemical akylation of N-heterocyclic compounds', 'R', 'RX, X = CI, Br', 'NH', 'N-R', 'K2CO3,MeCN', 'Pyrazoles', '1-Alkylpyrazoles', '2-Alkylpyrazoles', 'R', 'RX, X=CI, Br, I, OTs', 'R', 'HN-N', 'N', '-N', 'N', 'N', 'N', 'NaOH', '1,2,3-Triazole', '1-Alkyltriazole', '2-Alkyltriazole', 'RX,X=CI, Br,I', 'Solvent', 'H', 'R', '2-Pyridone', 'N-Alkyl-2-pyridone', '2-Alkoxypyridine', 'b)MT-catalysed methylation of pyrazoles', 'CH3', 'MTs', 'NH', 'N', 'or', 'CHa', 'Pyrazoles', '1-Methylpyrazoles', '2-Methylpyrazoles', 'NH', 'NH2', 'OOC', 'NH3*', 'OHOH', 'OHOH', 'SAM', 'SAH', 'c)Synthesis of cxSAM and cxSAE', 'NH2', 'NH2', 'R', 'CmoA', 'NH3', 'Prephenate', 'NH3', 'OHOH', 'OHOH', 'SAM (R =H)or SAE (R=CH3)', 'cxSAM(R=Hor cxSAE(R=CH)'] | {'MTs': [{'substrate': ['Pyrazoles', 'CH3'], 'products': ['1-Methylpyrazoles', '2-Methylpyrazoles']}], 'CmoA': [{'substrate': ['Prephenate', 'SAM (R =H)or SAE (R=CH3)'], 'products': ['cxSAM(R=Hor cxSAE(R=CH)']}]} | |
67 | ['Chemoenzymatic synthesis of SAM analogues', 'NH3*', 'Na, NH3, -78C', 'OOC', 'OOC', 'COO', 'CHN', 'NH3', 'R-Br', 'Br', 'Homocystine', 'Methionine analogue', 'NH2', 'NH2', 'OOC', '0', '0', 'MAT', 'HO', 'NH3', 'OH', 'OH', 'OH', 'NH3', 'P; + PPi', 'Methionine analogue', 'OHOH', 'OHOH', 'ATP', 'SAM analogue', 'NH2', 'NH2', 'Halogenase', '000', 'NH3', 'NH3', 'X', 'Methionine analogue', 'OHOH', 'OHOH', "5'-Chloro-5'-deoxyadenosine(X=CI)", 'SAM analogue', "or 5'-fluoro-5'-deoxyadenosine (X=F)", 'NH', 'bChemical synthesis of SAM analogues', 'NH2', 'NH2', 'RX, X=Br or', 'R', 'OSOCF3', 'OO', '000', 'NH3', 'HCOH,AcCOH', 'NH3*', 'NH3', 'OHOH', 'OHOH', 'HOHO', 'SAH', '(S,S)-SAM analogue', '(R,S)-SAM analogue', '(Biologically active)', '(Potent MT inhibitor)'] | {'Methionine Adenosyltransferase (MAT)': [{'substrate': ['Methionine Analogue', 'ATP'], 'products': ['SAM Analogue', 'AMP']}], 'Halogenase': [{'substrate': ['Methionine Analogue', "5'-Chloro-5'-deoxyadenosine (X=CI)"], 'products': ['SAM Analogue']}, {'substrate': ['Methionine Analogue', "5'-Fluoro-5'-deoxyadenosine (X=F)"], 'products': ['SAM Analogue']}], 'Alkyl Triflate/Bromide': [{'substrate': ['SAH', 'Alkyl Triflate/Bromide'], 'products': ['(S,S)-SAM Analogue', '(R,S)-SAM Analogue']}]} | |
68 | ['aHMT-MT cascade reactions', 'MT', 'Alkylated', 'Substrate', 'product', 'NH2', 'NH2', 'R', '000', 'NH3', 'NH3', 'HOHO', 'HOHO', 'SAM analogue', 'SAH', 'R-I', 'HMT', 'b)Methylated products', 'OH', 'NH', 'HO', 'OH', 'CH3', 'CH3', 'CH2', 'CH3', 'HO', 'OH', 'HO', "'OH", 'N-CH3', 'H3C', 'R', 'OH', 'N', 'OH', 'CH3', 'CH3', 'Ononitol', 'N-Trimethylhistidine', 'N,N-Dimethylputrescine', 'B-Methyl-a-keto acids', '2.7-Dihydroxy-1-', 'methyinaphthalene', 'c) Alkylated products', 'OH', 'CH', 'HO', 'H', 'HO', 'HO', '1-Ethyl-5-cyclo-', '1-Propyl-5-cyclo-', '4-Allyloxy-3-hydroxy-', "4'-O-Ethylluteolin", 'propylpyrazole', 'propylpyrazole', 'benzaldehyde'] | {'Halide Methyltransferase (HMT)': [{'substrate': ['Methyl Iodide', 'SAH'], 'products': ['SAM', 'Iodide']}], 'Methyltransferase (MT)': [{'substrate': ['SAM'], 'products': ['Methylated Products']}], 'Alkyl-Promiscuous MTs': [{'substrate': ['SAH'], 'products': ['Alkylated Products']}]} | |
69 | ['3a', '77%', '88%', '4a', '8a', 'late', 'early', '80%', 'metalation', 'metalation', '80%', '15', '10a', 'a)', 'b', '13%', '67%', 'R=CgF', '17', 'NHFmoc', 'HO', '18', 'NHFmoc', 'H', 'OPfp'] | {'Mn(OAc)2\u2009×\u20094 H2O, NaOAc, EtOH, r.t.': [{'substrate': ['3a'], 'products': ['4a']}], 'NαFmoc-lysine, Hünig base, DMF/water, 2:1, 80\u2009%': [{'substrate': ['4a'], 'products': ['8a']}], 'PfpOH, EDC, CH2Cl2, EtOAc, yield 80\u2009%': [{'substrate': ['8a'], 'products': ['10a']}], 'Manganese acetate': [{'substrate': ['15'], 'products': ['17']}], 'Pfp ester': [{'substrate': ['17'], 'products': ['18']}]} | |
70 | ['cycle', 'R', 'cycle', 'R', 'R2', 'R3', '4a-g', 'R3', '1a-s', 'R3', '3a-n'] | {'Montmorillonite K-10': [{'substrate': ['five- or six-membered cycle', 'benzaldehyde'], 'products': ['Bis-arylidene derivatives 1\u2009a–s']}], 'HCl(g)': [{'substrate': ['five- or six-membered cycle', 'benzaldehyde'], 'products': ['Bis-arylidene derivatives 1\u2009a–s']}], 'CH3CO2H': [{'substrate': ['five- or six-membered cycle', 'benzaldehyde'], 'products': ['Bis-arylidene derivatives 1\u2009a–s']}], 'LiAlH4': [{'substrate': ['RC56'], 'products': ['2\u2009a']}], 'Suzuki coupling reaction': [{'substrate': ['3\u2009d', '3\u2009f'], 'products': ['3\u2009f']}]} | |
71 | ['R-H', 'R', "'PC-H", 'P('] | {'PC*': [{'substrate': ['R-H'], 'products': ['R', "'PC-H"]}, {'substrate': ["P('"], 'products': ['R-H']}]} | |
72 | ['N', 'C6H13', '16', 'PrOiOC', '17', '215W', 'household', 'COOH', 'bulbs,2 h', '0.1 equiv.)', 'OOP', 'HN', '18', 'COO/Pr', 'r.t.', 'NH2OH-HCI', '20 h', 'EtoN', 'OH', 'H', '19,95%', '20,89%'] | {'Phenylglyoxylic acid': [{'substrate': ['C6H13', '16'], 'products': ['18']}], 'Diisopropyl azodicarboxylate': [{'substrate': ['17'], 'products': ['18']}], 'Ethanolamine': [{'substrate': ['18'], 'products': ['19']}], 'Hydroxylamine hydrochloride': [{'substrate': ['18'], 'products': ['20']}]} | |
73 | ['C5H1', '33: 65%', 'cis/trans=65:35', 'COOEt', 'PTFE tubing', 'V=10mL', 'NaBH4', 'in EtOH', 'H', 'COOEt', 'COOEt', 'CgH13', 'COOEt', 'COOEt', "31'", '32', 'Et000', '[HW1oO32]4', '[W10O32]4', 'EtOOC', '125W', 'Hg lamp', '[W10O32', '30', 'C6H13', 'PTFE tubing', '16', 'V=12 mL', '0.1 mLmin-1'] | {'TBADT': [{'substrate': ['Heptanealdehyde (16)', 'Diethyl maleate'], 'products': ['Radical adduct 31·', 'Hydroacylated derivative 32']}], 'NaBH4': [{'substrate': ['Hydroacylated derivative 32'], 'products': ['γ-lactones (33)']}], 'Sunlight': [{'substrate': ['Dimethyl(phenyl)silane (43)', 'Phenyl vinyl sulfone (44)'], 'products': ['Adduct 45']}]} | |
74 | ['1a', '[Ru"] (5 mol-%)', '+', 'TBHP (4 equiv.)', 'MeCN,hv,40 h', 'Ph', 'Ph', 'Ar', '86:64%', '85', 'Ph', '34W', 'tBuOOH', 'hi', 'blue LED', '[Ru"]', 'HO+', 'tBuO', '[Rull', 'HA', '1a', 'tBuOH', 'Ph', "4'a", 'H', '.88', '85', '88', 'HO', 'HO', '86', 'uc', "87'", '[Ru]=Ru"(bpV)3Cl'] | {'RuII(bpy)3Cl2': [{'substrate': ['TBHP', 'THF', 'benzaldehydes', 'styrenes', 'alkynes', 'aldehydes'], 'products': ['tert-butoxyl radical', 'α-oxy radical', 'adduct', 'cation', 'deprotonation', '3-sulfonylated coumarins', 'vinylation', 'α,β-epoxy ketones', 'benzoyl radicals', 'acyl chlorides', 'benzamides']}], 'TBHP': [{'substrate': ['THF', 'alkynoates', 'arylsulfinic acids', 'phenyl propiolates', 'alkynes', 'styrenes', 'benzaldehydes', 'aldehydes'], 'products': ['tert-butoxyl radical', 'α-oxy radical', 'adduct', 'cation', 'deprotonation', '3-sulfonylated coumarins', 'vinylation', 'α,β-epoxy ketones', 'benzoyl radicals', 'acyl chlorides', 'benzamides']}], 'N-chlorosuccinimide': [{'substrate': ['aldehydes'], 'products': ['benzoyl radicals', 'acyl chlorides', 'benzamides']}]} | |
75 | ['Acridine red (2 mol-%', 'TBHP (4 equiv.),4 A MS', 'Acetone,r.t.,12 h', '3 W green LED', '100a: 67%(R =H)', '98', 'b:55%(R=Me)', '99a-c', 'c: 70% (R = CI)'] | {'Acridine red': [{'substrate': ['TBHP', '1,4-dioxane'], 'products': ['99a-c', '100a-c']}], 'TBHP': [{'substrate': ['1,4-dioxane'], 'products': ['99a-c', '100a-c']}], 'MS': [{'substrate': ['1,4-dioxane'], 'products': ['99a-c', '100a-c']}], 'Acetone': [{'substrate': ['1,4-dioxane'], 'products': ['99a-c', '100a-c']}], 'LED': [{'substrate': ['1,4-dioxane'], 'products': ['99a-c', '100a-c']}]} | |
76 | ['OH', 'HO', '5', '2a', '6a-46a', 'R', 'HO', 'HO', 'OH', '2b', '6b-46b', 'R'] | {'Friedel–Crafts acylation': [{'substrate': ['2-bromothiophene', 'glutaric anhydride'], 'products': ['precursor 5']}], 'Suzuki reaction': [{'substrate': ['precursor 5'], 'products': ['2a']}], 'Coupling': [{'substrate': ['2a'], 'products': ['6a-46a']}]} | |
77 | ['H', 'GalOx', 'OH', 'OH', 'HMF', 'FDCA', 'DFF', '02', 'H2O2', 'CalB', 'HOO', 'OH', 'OH'] | {'GalOx': [{'substrate': ['HMF'], 'products': ['DFF', 'H2O2']}], 'CalB': [{'substrate': ['H2O2', 'Ethyl Acetate'], 'products': ['Peracetic Acid']}], 'Peracetic Acid': [{'substrate': ['DFF'], 'products': ['FDCA']}]} | |
78 | ['HzO2', 'HMF', 'Ethyl acetate', 'one phase', 'FDCAL', 'Buffer', 'GalOx + HRP + catalase', 'CalB (peracid-mediated)', 'HO', 'HO', 'OH', 'DFF', 'DFF', 'FDCA', 'HMF'] | {'GalOx + HRP + catalase': [{'substrate': ['HMF'], 'products': ['HO', 'OH']}], 'CalB (peracid-mediated)': [{'substrate': ['DFF'], 'products': ['FDCA']}]} | |
79 | ['Ar', 'Ar_air, KIO30 mol%)', '24 examples', 'HC', 'ethyl lactate,90', '75-85% yield', 'R1=Ar,AIkyl;Ar=4-MePh2-MePh,4-CIPh4-BrPh', 'R2=R3=H.Me,Et,Pr', 'R2=Me,H;R3=4-MePh,3-CIPh', 'Atom economy ', 'E-factor', 'Safety', 'Solvent '] | {'KIO3': [{'substrate': ['enaminones', 'thiophenols'], 'products': ['aminothioalkenes']}]} | |
80 | ['2 mol% AuCl', 'OH', 'MeNO2,65-100C', 'R', 'R1', '-R3 + R4SH', 'R3', 'R2', '2 mol%Pd(OAc)2', '2 mol% AuCI', 'MeNO2,80 C', 'a', 'AlK', 'AI', 'H SAr2', 'H SAr2', 'H SAr', '16 examples', '7 examples', '6examples', '60-97% yield', '62-97% yield', '47-71% yield', '(b)', 'SAr', 'SPh', 'SAIK', 'SAr/AIk', '10 examples', '99%yield', '3examples', '4 examples', '94-99% yield', '80-84% yield', '69-98% yield', '(c)', 'AlK', 'R2S', 'PhS', 'i-Pr', 'PhS Ph', '6 examples', '3 examples', '3examples', '79-94% yield', '64-82% yield', '73-84% yield', 'SPh', 'SPh', 'n=1,2', '58-93% yield', '98% yield', '75% yield', 'Atom economy', 'E-factor', 'Safety', 'Solvent'] | {'AuCl': [{'substrate': ['R', 'R1'], 'products': ['R3', 'R4SH']}], 'Pd(OAc)2': [{'substrate': ['R3'], 'products': ['R2']}, {'substrate': ['R2S'], 'products': ['PhS']}]} | |
81 | ['A', 'iso', 'TE', 'Acyl-', 'CoA DH', 'DS', 'Amt', 'ER', 'FAAL', 'ACP', 'DH', 'AT', 'ACF', 'B', 'Iso2', 'Iso5', 'Iso6', 'Iso9', 'Module 1', 'Module 2', 'Module 3', 'Iso7', 'Module 4', 'Acyl-', 'CoA DH', '*', 'Amt', 'ER', 'FAAL', 'ACP', 'KS', 'AT', 'ACP', 'ACP', 'ACP', 'ACP', 'DH', 'KR', 'ACF', 'TE', 'HO', 'Am', 'Iso4', 'spontaneous,', 'amino', 'SBpaXO HN', 'cyclization', '-H2O', 'trans-', 'Hdomain', 'ferase', 'thioesterase', 'domain', 'c', 'ACP', 'ACP', 'ACP', '1a-4a', 'Amt', 'o', '-NH2', 'Iso4', 'Iso3', 'Iso9', 'amino', 'oxidase', 'NH', 'desaturase', 'trans-', 'ferase', '10', '7a)', 'D', 'ACP', 'ACP', 'ACP', 'ACP', 'ACP', 'ACP', 'Beckmann', 'Iso4', ' spontaneous', 'rearrangement', 'Iso3', 'amino', '-NH2', 'NH2', 'cyclization', '-HzO', '5/6', 'trans-', 'domain', 'ferase', 'OH', 'VH2', 'HO', '(5a/6a)', 'E', 'ACP', 'ACF', 'ACP', 'ACP', 'ACP', 'FAAL:fatty acyl-adenosine monophosphate ligase', 'Amt:aminotransferase', 'DS:Fatty acid desaturase', 'Acyl-CoA DH: acyl-coenzyme A dehydrogenase', 'Ccondensation', 'OxOxidation enzyme', 'ACP:acyl carrier protein', 'DH:dehydratase', 'R1:CH3 or H', 'gene', 'KS: ketosynthase', 'ER:enoyl reductase', 'R2: OH or =O', 'AT:acyl transferase', 'domain', 'KR:ketoreductase', '*possibly act iterative on octanoic', 'TE: thioesterase', 'acid-based precursors'] | {'Iso2': [{'substrate': ['3-oxodecanoic acid', '9-methyl-3-oxodecanoic acid'], 'products': ['acid-adenosine monophosphate (AMP)']}], 'Iso5': [{'substrate': ['decanoic acid', 'malonyl-coenzyme A (CoA)'], 'products': ['acyl chain']}], 'Iso6': [{'substrate': ['acyl chain'], 'products': ['amino group']}], 'Iso4': [{'substrate': ['amino group'], 'products': ['oxime']}, {'substrate': ['second carbonyl', 'third carbonyl'], 'products': ['hydroxy group']}], 'Iso6 C-domain': [{'substrate': ['oxime'], 'products': ['hemiacetal intermediate']}, {'substrate': ['secondary amine'], 'products': ['cyclized five-membered scaffold']}], 'Iso3': [{'substrate': ['oxidized derivative'], 'products': ['myxofacycline 1 or 2', 'myxofacycline 5 or 6']}]} | |
82 | ['{RhcodCI}],NHCI', 'NH', 'tBujosiphos,H2', 'NH.OAc', '98% yield', '95% ee', '92% yield', '>99.95% ee', '(R)-transaminase', 'FC', 'NH2'] | {'Rhodium-catalyst': [{'substrate': ['NHCI', 'tBujosiphos', 'H2'], 'products': ['NH', 'OAc']}], '(R)-transaminase': [{'substrate': ['FC'], 'products': ['NH2']}]} | |
83 | ['Alternating Current Electrolysis', 'R1-S-S-R1', 'oxidation', '10 mA', 'R1-S-S-R2', 'R2-S-S-R2', 'R1-S-S-R3', 'current', 'R3-S-S-R3', '-10 mA', 'R2-S-S-R3', 'reduction', 'etc.', 'time', 'etc.'] | {'Alternating Current Electrolysis': [{'substrate': ['R1-S-S-R1', 'R2-S-S-R2', 'R3-S-S-R3'], 'products': ['R1-S-S-R2', 'R1-S-S-R3', 'R2-S-S-R3']}]} | |
84 | ['Br+2OH', 'A', '2 H2O', 'N', '2e', 'OH', '1', 'H0', '2OH', '2e', 'OH', 'BrC', 'OH', '2Hads', 'glucose', 'CO2H', 'CH2OH', 'H', 'HO', 'H', 'OH', 'HO', 'H', 'HO', '-H', 'H', 'OH', 'H', 'HO', 'H', 'OH', 'H', 'OH', 'gluconic acid', 'CHOH', 'CHOH', 'sorbitol'] | {'Br+2OH': [{'substrate': ['glucose'], 'products': ['gluconic acid', 'sorbitol']}], 'A': [{'substrate': ['glucose'], 'products': ['gluconic acid', 'sorbitol']}], '2 H2O': [{'substrate': ['glucose'], 'products': ['gluconic acid', 'sorbitol']}], 'N': [{'substrate': ['glucose'], 'products': ['gluconic acid', 'sorbitol']}], '2e': [{'substrate': ['glucose'], 'products': ['gluconic acid', 'sorbitol']}], 'OH': [{'substrate': ['glucose'], 'products': ['gluconic acid', 'sorbitol']}], '1': [{'substrate': ['glucose'], 'products': ['gluconic acid', 'sorbitol']}], 'H0': [{'substrate': ['glucose'], 'products': ['gluconic acid', 'sorbitol']}], '2OH': [{'substrate': ['glucose'], 'products': ['gluconic acid', 'sorbitol']}], 'BrC': [{'substrate': ['glucose'], 'products': ['gluconic acid', 'sorbitol']}], '2Hads': [{'substrate': ['glucose'], 'products': ['gluconic acid', 'sorbitol']}], 'CO2H': [{'substrate': ['glucose'], 'products': ['gluconic acid', 'sorbitol']}], 'CH2OH': [{'substrate': ['glucose'], 'products': ['gluconic acid', 'sorbitol']}], 'H': [{'substrate': ['glucose'], 'products': ['gluconic acid', 'sorbitol']}], 'HO': [{'substrate': ['glucose'], 'products': ['gluconic acid', 'sorbitol']}], '-H': [{'substrate': ['glucose'], 'products': ['gluconic acid', 'sorbitol']}], 'CHOH': [{'substrate': ['glucose'], 'products': ['gluconic acid', 'sorbitol']}]} | |
85 | ['a)', 'pH 3.3', '80', 'pH 4.3', 'pH5.2', 'pH 6.1', '60', 'pH 7.1', 'FI Intensity / a.u', 'pH 8.2', '365nm UV Light', '40', '20', '0', '500', '520', '540', '560', '580', '600', '620', '640', 'b)', 'Wavelength/nm', '7.5', '5U of BL in 10mg of PenG/10mL', '7.0', '5U of BL in 25mg of PenG/10mL', '5U of BL in 50mg of PenG/10mL', '6.5', '5U of BL in 100mg of PenG/10mL', '6.0', '5.5', '5.0', '4.5', '4.0', '0', '1', '2', '3', '4', '5', '6', '7', '8', '9', '10', 'Time/hr'] | {'β-lactamase': [{'substrate': ['penicillin G'], 'products': ['penicilloic acid']}]} | |
86 | ['b)', 'a', '100%', '100%', 'fluorescenceintensity', 'Relative fluorescence intensity', 'FMSNP/PenG', '80%', 'Std BL 0.5U', '80%', 'Std BL0.025U', 'Std BL 6.2510U', '60%', '-Std BL3.1310U', 'Std BL 1.5610U', '60%', 'Std BL 7.8210U', '40%', 'Relative', '40%', 'FMSNP/PenG', 'Wild type-AB(S', '7398-AB(S', '20%', '20%', '78578-KP(S', '25992-E.Coli (S', '0%', '0%', '0', '1', '2', '3', '4', '5', '6', '7', '8', '9', '10', '0', '2', '3', '5', '6', '7', '8', '9', '10', 'Time/hr', 'Time/hr', 'd)', '100%', 'Std BL 0.5U', '100%', 'Std BL0.025U', '7018-AB (R)', 'intensity', '55595-E.coli(R', 'intensity', 'IMP32-AB(R)', '80%', '80%', '55219-E.coli (R', '82385-AB (R', 'fluorescence', '77893-AB (R)', 'fluorescence i', '54113-E.Coli(R', '60%', '60%', '70383-KP (R)', '40%', '40%', 'Relative', 'Relative', '20%', '20%', '0%', '0%', '0', '1.', '5', '6', '1', '0', '2', '3', '4', '5', '6', '7', '8', '10', '8', '6', '10', 'Time/hr', 'Time/hr', 'e)', 'f)', '100%', 'Std BL 7.8210-4', '100%', 'Std BL 7.8210', '77815-AB (R)', ' intensity', '77815-AB (R)', '80%', '80%', 'fluorescence', '60%', '60%', '40%', 'Relative f', '40%', '20%', '20%', '0%', '0', '1', '2', '3', '4', '5', '6', '7', '8', '9', '10', '0%', '0', '1', '2', '3', '4', '5', '6', '7', '8', '9', '10', 'Time/hr', 'Time /hr'] | {'β-lactamase': [{'substrate': ['FSNP/PenG'], 'products': ['fluorescence']}]} | |
87 | ['rtho Substitution', 'OH', '1 BnBr', '3', '2) PhB(OH)2, Pd(PPh)4', 'Piperidine', '1KCO3DMF/CHO,Reflux 1-3 h', 'EtOH,reflux,12 h', 'Br', '2NaCO3,Toluene:EtOH,80C', 'Ph', 'Ph', '79c', '80i', '81i', '81%', 'IC5o=16M', 'Para Substitution', '1R4BnBr', '3', '2) PhBOH)2,Pd(PPh3)4', 'Piperidine', 'HO', '1) KCO3,DMF/(CH3)O,Reflux 1-3 h', 'EtOH, reflux, 12 h', 'Br', '2NaCO3.TolueneEtOH,80C', 'Ph', '82c', '83g-h', '84g R4 = H', '84h R4=p-CF3', '84g-h', '86-90%', 'IC5o=6-9M'] | {'Pd(PPh)4': [{'substrate': ['PhB(OH)2', '1BnBr'], 'products': ['Ph', '79c']}, {'substrate': ['PhB(OH)2', '1R4BnBr'], 'products': ['Ph', '82c']}], 'Pd(PPh3)4': [{'substrate': ['PhB(OH)2', '1R4BnBr'], 'products': ['Ph', '83g-h']}], 'KCO3': [{'substrate': ['1BnBr'], 'products': ['80i']}, {'substrate': ['1R4BnBr'], 'products': ['84g-h']}], '2NaCO3': [{'substrate': ['Br'], 'products': ['84g R4 = H', '84h R4=p-CF3']}]} | |
88 | ['ve', 'NH2', 'cat.DMAP', 'CHCI', '8%', 'MeO', 'MeO', 'OMe', 'TR', 'NH'] | {'cat.DMAP': [{'substrate': ['bis-amine 3', 'methoxyisophthaloyl dichloride'], 'products': ['[2]catenane 4']}], 'TR': [{'substrate': ['bis-amine 3'], 'products': ['[2]catenane 4']}]} | |
89 | ['Ph', 'Ph', 'sophthaloyl dichloride', 'CHCI3/CH3CN (9:1', 'p-xylenediamine', 'NEt3', '97%', 'NH HN', 'Ph', 'Ph', 'NH HN'] | {'p-xylenediamine': [{'substrate': ['isophthaloyl dichloride'], 'products': ['fumaramide axle 8']}], 'NEt3': [{'substrate': ['fumaramide axle 8'], 'products': ['rotaxane 9']}]} | |
90 | ['12X=Bn,n=1', '13X=Bn,n=2', '14X=Ph,n=2', 'isophthaloyldichloride', 'p-xylenediamine', 'CHCl3', 'NEt3', 'NH HN', 'NH HN', 'NH HN', '15X=Bnn=1,8%', '16X=Bnn=2,17%', '17X=Ph.n=2.40%'] | {'NEt3': [{'substrate': ['isophthaloyldichloride', 'p-xylenediamine'], 'products': ['12X=Bn,n=1', '13X=Bn,n=2', '14X=Ph,n=2']}], 'CHCl3': [{'substrate': ['12X=Bn,n=1', '13X=Bn,n=2', '14X=Ph,n=2'], 'products': ['15X=Bnn=1,8%', '16X=Bnn=2,17%', '17X=Ph.n=2.40%']}]} | |
91 | ['+', 'HN', '108', '109', 'tBu', '107', 'CHCI3', '45%', 'Bu', 'tBu', 'HN', '110', 'tBU'] | {'Nitrone-maleimide stoppering reaction': [{'substrate': ['108', '109', '107'], 'products': ['110']}]} | |
92 | ['CF', '117', 'CF3', '90', '118', 'Cu(CH3CN)4BF4', 'CH2Cl2', 'TBTA', 'DIPEA', '47%', 'VH', 'HN', 'F3C', 'NEN', '119', '(b)', 'NH', 'HN', 'F3C', 'N=N', '120'] | {'Cu(CH3CN)4BF4': [{'substrate': ['CF3', '90', '118'], 'products': ['CF', '117', '119']}], 'TBTA': [{'substrate': ['119'], 'products': ['120']}], 'DIPEA': [{'substrate': ['120'], 'products': ['NH', 'HN', 'F3C', 'N=N']}]} | |
93 | ['B', 'Hemiketal Mechanism', 'Hydride-transfer Mechanism', 'Coupled proton-hydride transfer', 'CO2H', 'CO2H', 'HO2C', 'HN', 'HOC', 'HN', 'hydride transfer', 'MeO', 'OMe', 'tBu', 'proton coupled', 'o-Q', 'electron transfer', 'o-Q', 'Asp', 'Asp', 'CO2Me', 'CO2Me', 'CO2Me', 'MeO2C', 'HN', 'MeO2C', 'HN', 'MeO2C', 'HN', '+ EtOH', '+ DBU', 'HO', '-EtOH', 'H', 'MeCHO', '[M(1]2+', '[M(1OEt)]2', '[M(1H2)]2+', 'aNO', '[La(LQQ)(NO3)3]', '[La(LQQH)(NO3)3]', '+2,6-lutidine', 'OH', '- 2,6-lutidine', 'OF', 'La(NO3)3', '[La(LQqH2)(NO3)3]'] | {'Hemiketal Mechanism': [{'substrate': ['EtOH', 'DBU'], 'products': ['MeCHO', 'Acetaldehyde']}], 'Hydride-transfer Mechanism': [{'substrate': ['4-methyl benzyl alcohol'], 'products': ['MeCHO']}], 'Coupled proton-hydride transfer': [{'substrate': ['benzylic alcohol'], 'products': ['MeCHO']}]} | |
94 | ['100', '90', '80-', '70', 'Ba2+', '-09', 'Ca2+', '50-', "'ield", 'La3+', '40', 'Lu3+', '30', '20-', '10-', '0', '0', '200', '400', '600', '800', '1000', '1200', '1400', 'Time (min)'] | {'PQQMe2-1-aza-15-crown-5': [{'substrate': ['4-methyl benzyl alcohol'], 'products': ['4Me-PhCHO']}], 'Ba(OTf)2': [{'substrate': ['4-methyl benzyl alcohol'], 'products': ['4Me-PhCHO']}], 'Ca(OTf)2⋅H2O': [{'substrate': ['4-methyl benzyl alcohol'], 'products': ['4Me-PhCHO']}], 'Ln(OTf)3⋅3\u2009H2O': [{'substrate': ['4-methyl benzyl alcohol'], 'products': ['4Me-PhCHO']}], 'La(NO3)3⋅6\u2009H2O': [{'substrate': ['4-methyl benzyl alcohol'], 'products': ['4Me-PhCHO']}], 'DBU': [{'substrate': ['4-methyl benzyl alcohol'], 'products': ['4Me-PhCHO']}], '2,6-lutidine': [{'substrate': ['4-methyl benzyl alcohol'], 'products': ['4Me-PhCHO']}], 'pyridine': [{'substrate': ['4-methyl benzyl alcohol'], 'products': ['4Me-PhCHO']}]} | |
95 | ['A)', '1143', '1114', '80s', '100ms', '1104', '1800', 'v/cm-', '950', 'B)', 'Mg', 'Lys 16', 'Arg'] | {'GAP': [{'substrate': ['GTP'], 'products': ['GDP', 'Pi']}]} | |
96 | ['CHO', 'COOH', 'H', '-OH', 'H-', '-OH', 'HO', '-H', 'GOx', 'HO', '-H', '+02', 'H', 'OH', 'H', 'OH', 'H', 'OH', 'H', 'OH', 'CH2OH', 'CHOH', 'Glucose', 'Gluconic acid', 'NH2', 'HO2', 'TMB', '+', '?', 'H2N', 'NH2', 'Porphyrin Nanocomposite', 'HO', 'oXTMB'] | {'Glucose Oxidase': [{'substrate': ['Glucose'], 'products': ['Gluconic acid', 'H2O2']}], 'Porphyrin Nanocomposite': [{'substrate': ['H2O2'], 'products': ['TMB', 'oXTMB']}]} | |
97 | ['H2O', 'H', '-OPP-', 'FPP', 'C. intybus', 'ZmEDS', 'JH', 'OH', 'OH', 'HO', '12', '13', 'B)', 'HO', 'H+', 'H', 'OF', '+-', '14', '15', 'OH', '16'] | {'Cichorium intybus': [{'substrate': ['1'], 'products': ['12']}], 'ZmEDS': [{'substrate': ['1'], 'products': ['13']}], 'Acid-catalysed reaction': [{'substrate': ['1'], 'products': ['14', '15', '16']}]} | |
98 | ['H', 'H', 'H', 'OH', 'OH', 'HO', 'OH', 'L1', 'L2', 'L3', 'L4', '0', 'F', 'H+', '10', '(-)-1', 'OH', 'H', 'H', 'OH', 'OH', 'OH', 'OH', 'L5', 'L6', 'L7', 'L8'] | {'H+': [{'substrate': ['Hedycaryol'], 'products': ['L1', 'L2', 'L3', 'L4', 'L5', 'L6', 'L7', 'L8']}]} | |
99 | ['OH', 'SalAI-SalAIX', 'PKS', 'OF', 'Salc', 'OF', 'SalD', '(SalE)', 'OF', 'SalB enzymes', 'OH', 'OH', 'chain', 'chain', 'release', 'release', '3'] | {'SalE': [{'substrate': ['SalAI-SalAIX', 'Salc'], 'products': ['SalD', '3']}], 'PKS': [{'substrate': ['SalAI-SalAIX'], 'products': ['Salc']}], 'SalB': [{'substrate': ['SalD'], 'products': ['OH', 'chain', 'release']}]} |
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