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Bioinformatics Scientist 2 . Oncology bioinformatics to support CDx development . Responsibilities include data analysis and pipeline development . . I am a bioinformatics scientist with a background in human genetics . I posses strong communication skills and operate with a high level of accountability to deliver high quality analysis and tools . Specialties : human genetic data analysis , bioinformatics , population evolutionary genomics , clinical genomics , clinical variant curation and reporting , variant calling , denovo long gread genome assembly , RNA seq analysis , epitope prediction , Bayesian networks , Python , Unix , R , Rshiny , Matlab , MongoDB , Docker , AWS EC2 , Apache Spark . Technologies :

Bioinformatics Scientist . . . Technologies :

Senior Scientist . . 1 Filed and published over 50 patents and papers in small molecule drug discovery 2 Devised strategies to solve difficult problems and accelerate drug discovery projects 3 Designed and synthesized DNA encoded libraries 4 Strong communication , interpersonal and project management skills . Technologies :

small molecules;screening

Scientist . Department of Microbiology and Molecular Medicine MIMOL Ultrastructural characterization of Toxoplasma gondii parasite at different stages during the life cycle Cyst wall ultrastructure of bradyzoites stage in infected mouse brain Serial sections TEM Correlative light and electron microscopy of the brain tissue FIB SEM microscopy Electron tomography 3D reconstruction . I am electron microscopy specialist with more than 25 years hands on experience with broad range of skills and expertise especially in transmission electron microscopy TEM , in both sample preparation and results analysis . fixation glutaraldehyde , paraformaldehyde , osmium tetroxide , vitrification embedding Epon , Spurr , LR White , LR Gold , Lowicryls ultrathin sectioning plastic and cryo contrasting with uranyl acetate and lead citrate negative staining conventional and sandwich techniques quick freezing freeze drying and or fracturing metal shadowing ; glycerol spraying and low angle metal shadowing sputter coating and vacuum evaporation of C , Pt , Ta W , and Au immuno labeling both pre and post embedded colloidal gold preparation and coupling with antibody ; stereological evaluation of immuno labeled samples immunocytochemistry GraFix gradient fixation method preparation of support films for EM grid formvar , parlodion , and holey carbon film for cryo EM conventional EM and cryo EM single particle analysis and or tomography advanced user of different types of TEMs : EFTEM Omega EM912 , JEOL 1200 , 1011 , and 2010 , Phillips EM 400 , Morgagni 268 D , Tecnai T12 , F30 , and Spirit BioTWIN operation of SEMs : XLFF30 FEG FEI , Zeiss Merlin , Zeiss Nvision 40 FIBSEM data acquisition : iTEM , DigitalMicrograph , and FEI TIA image processing and visualisation : EMAN , EMAN2 , SPIDER , IMOD , FIJI , Photoshop , UCSF Chimera , ilastik , Blender Specialties : Electron microscopy techniques Immunogold labeling techniques Image acquisition and processing 2D averaging and 3D reconstruction , single particle analysis , tomography Biochemical methods SDS PAGE , Western blotting , ultracentrifugation sucrose cushion , analytical sucrose gradient , enzyme activity assay , ... Cell fractionation Cell culture macrophage RAW264.7 , fibroblast BHK 23 Mass spectrometry in gel trypsin digestion , peptide mass finger printing by MALDI TOF MS . Technologies : CryoEM;AUC

antibodies;structure

Senior Staff Scientist in CryoEM Structural Biology . . 4 years of cryo electron microscopy cryoEM experience Negative staining and cryoEM with CM120 , CM200 , JEOL 2200FS , Arctica , and Krios 10 years of experience in protein biochemistry , biophysics , and structural biology Protein antibody expression techniques : prokaryotic expression , eukaryotic expression yeast , 293 cell line , and sf9 insect cell line Protein antibody purification techniques : affinity chromatography protein A G , Ni , GST , and MBP , ion exchange , gel filtration , etc . Protein structure determination from either X ray diffraction data or cryoEM data Crystallization of membrane proteins and protein complexes protein protein , protein peptide , protein drug , protein antibody Crystallization techniques : batch method , microbatch method , hanging or sitting drop vapor diffusion method , and seeding Biophysical and biochemical techniques : PCR , gene clone , Western blot , Native PAGE by GE PhastSystem , Dynamic Light Scattering DLS , Circular Dichroism CD , Isothermal Calorimetry ITC , BioLayer Interferometry BLI , and Analytical Ultracentrifugation AUC Anaerobic operation in COY and MBraun chamber . Technologies : Xray;CryoEM;ITC;SLS DLS;BLI;AUC;CD

antibodies;membrane proteins;peptides;proteins;characterization;interaction;structure

Division Director , Division of Mathematical Sciences . . Administrative As DMS director , I administer a portfolio of programs with an annual budget in excess of 230 million for a division whose mission is to fund groundbreaking research in mathematics and statistics , and support education and training in the mathematical sciences . Prior to my NSF appointment , I was the Dean and primary executive officer for UC Merced 's School of Natural Sciences . Managed annual balanced budgets of over 21 million , oversaw distribution of 30 M in graduate student support , and supervised staff of 54 . Academic R D in computational sciences and mathematics . Specialties : computational mathematics , computational sciences , high performance computing , parallel programming , systems architectures , nonlinear optimization , machine learning . Technologies :

Tenure Track Scientist . . I am a structural biologist with my research focus to elucidate the structures of novel c di GMP and ppGpp receptors and c di GMP controlled Histidine kinases . I am employing various biochemical and biophysical techniques for functional characterization of signaling proteins in Bacteria . The investigations will contribute to the biological basis for the novel therapeutics and drug discovery . Specialties : Molecular Biology , Biophysics , Protein Biochemistry , Recombinant Protein Expression , and Purification , Protein Crystallisation , Structure Solution by X ray Crystallography , Small angle X ray scattering SAXS , Negative staining and Cryo EM . . Technologies : Xray;CryoEM

proteins;characterization;interaction;structure

Vice President , Clinical Development . . . Technologies :

. . MPhil candidate in Biochemistry . Passionate and self motivating in learning more knowledge about cryo electron microscopy cryo EM and Cryo ET . Interested in structural biology and relate protein functions to cellular events .. Technologies : CryoEM

proteins;structure

Computational Biologist . . I am currently pursuing my PhD in chemistry from Stanford University . I am working on MS based proteomics research in the Snyder Lab . I have extensive experience in the technical aspects of research project development , but I am also interested in the organizational and managerial elements involved in transforming cutting edge research into successful biotechnology companies . I am particularly interested in the work carried out by biotech incubators , consulting firms and venture capital firms ; all of which sustain the ecosystem for biotechnology firms to thrive . Given my background and interest , I was further motivated to join oSTEM and SBG during my time at Stanford . oSTEM , short for Out in STEM , supports the personal and professional development of LGBTQ students pursuing careers in STEM fields . More broadly , Stanford Biotechnology Group SBG , seeks to provide professional development opportunities beyond research for the graduate community at Stanford . I am very enthusiastic about the promise of biotech and work to bring others into this exciting industry .. Technologies :

Cryo Electron Tomography Specialist . . . Technologies : CryoEM

Biochemical technician . . During my bachelor 's thesis project , I have experienced production and purification of proteins causing amyloidosis 2 microglobulin and neuroserpin from E. coli and LEXSY expression system . During purification I used different chromatographic methods and SDS PAGE to analyse the efficacy of purification . I also performed circular dichroism analysis and activity tests to ensure the correct folding of proteins . I worked on my master thesis project , which consisted in purifying POMT1 2 enzyme from membranes of HEK293F cells , creating nanodiscs in order to reconstitute a physiological environment for enzyme , followed by biochemical analysis and Cryo EM in presence and absence of ligands . I also gave help in the lab 's project related to the purification of HCN2 channel , applying the same techniques as for POMT1 2 . Currently , I am working at Dia . Pro Diagnostic BioProbes s.r.l . as a lab technician in Strategic Materials section , in order to produce tracers and antigens and purifying antibodies for kit production ELISA , CLIA .. Technologies : CryoEM;CD

interaction;stability;structure

Nottingham Research Fellow . . Bachelor and Master in Chemistry , and PhD in Biophysics and 5 years of postdoc training in modelling and simulations of biomolecules , focusing on the folding of protein and RNA . Broad knowledge of different techniques in numerical simulations and biochemistry . Skilled in Molecular Dynamics and Modeling , Programming Python , Fortran , C C , High Performance Computing using MPI and OpenMP , Data analyses .. Technologies :

Computational Biologist . . . Technologies :

Associate Principal Scientist . Lead Chemist for several projects in early and late phase of drug discovery ; Medicinal Chemisty Department , Respiratory , Inflammation Autoimmunity RIA Kinase inhibitors , PPI Small molecules , PROTACs , New Modalities Using AI in drug discovery . . Technologies :

molecular glues;small molecules;developing;screening

Clinical Research Scientist . . . Technologies :

Research Leader Information Systems . . I 'm passionate about developing scientific software in the area of plant genetic resources , genetics and breeding . My group develops great tools ranging from the collection of experimental data in the field through to data visualization . I 'm a principal investigator for a number of open source biological database and visualization projects including the generic plant resources database Germinate and Helium for visualizing plant pedigrees . I work on a load of great projects with collaborators and funders around the world . Its great that we have excellent bioinformatics tools developed here in Scotland that are now used worldwide Looking at new tech at the moment so getting to grips with graph databases , R and Go . Always excited about what 's coming next and how we can develop my groups tools and resources to answer interesting questions or applying them to new challenges .. Technologies :

Scientist . Optimization of mouse lead antibodies for human therapeutics , assay development , design and implementation of automation , evaluation of new technologies , management of research operations . . I have extensive experience in design , validation and implementation of biochemical and cellular screening assays . My strengths include the utilization of binding assays and functional assays for target validation and profiling of novel small molecule and biotherapeutic agents . I am also proficient in mammalian cell culture and molecular cloning as additional support for research activities . Specialties : ELISA , HTRF , Antibody Optimization , Radioligand Binding , Cell Signaling Assays , Reporter Assays , Riboswitch In Line Probe Assays , Transcription Mediated Gel Based Assays , Lipid Metabolism Assays . Transient Stable Transfection , Creation Characterization of Clonal Cell Lines , Cultivation of Endogenous Recombinant Cell Lines . Southern , Northern , Western Blots , PCR , Primer Construction , Colony Hybridization , Site Directed Mutagenesis , DNA and RNA Purification , DNA Sequencing and Analysis , Plasmid Cloning , Bacterial Transformations .. Technologies :

antibodies;biologics;small molecules;expression;interaction;screening

Scientist Group Leader . . Lead a growing team at the Amgen Thousand Oaks site to determine macromolecular structures and provide structural insights into the development of innovative therapeutics . Amgen Cryo EM administrator and superuser ; oversee the Amgen Krios and Glacios microscopes operation , Cryo EM computing data storage platforms , and Cryo EM user training . A proven protein biochemist and structural biologist with 10 years of experience in biochemistry , X ray crystallography , and 7 years of hands on experience in Cryo EM , both single particle analysis and Cryo ET . Self motivated , humble , and highly productive with a strong publication record nine 1st author papers in high profile journals ; more than 20 high impact papers in total .. Technologies : Xray;CryoEM

proteins;structure

Co Founder Managing Director at ATEM Structural Discovery . ATEM Structural Discovery provides innovative cryo EM solutions to pharmaceutical and biotechnological industries . We support the most challenging discovery and quality control efforts and allows the structural elucidation of previously unfeasible drug targets . . Delivering solutions that leverage the power of next gen cryo EM structure based drug design . Success : delivering software enabled solutions in fast paced enterprise markets Vision : To ensure ATEM is recognised as a leading provider of cryo EM structural determination services . Service : Tailor solutions using ATEM s high resolution cryo EM platform to accelerate successful drug development pipelines for the pharmaceutical industry . As a Managing Director of ATEM , my goal is to provide strategies to the pharmaceutical biotechnological companies to fast track their rational drug design projects . We do this by providing the highest resolution 3D model of even the most challenging drug targets under the fastest turnaround time . ATEM is at the forefront of the cryo EM revolution in structural biology . Our unique and completely integrated platform incorporates cryo EM optimised biochemical processes with high end data acquisition hardware and data processing augmented by continuous machine learning enhancements . Our next gen proprietary software suite allows us to deliver more detailed , high resolution 3D structural models with higher accuracy and faster turnaround times . To find out more about ATEM , visit our website at : www.atem.bio or contact me at daniel.winkler atem.bio . Technologies : CryoEM

characterization;structure

RA Scientist . . I am a Biologist with a PhD degree in Health and Medical Sciences . In various university positions , I have been working with cell biology and biochemistry in topics related to oncology , toxicology , and neurodegeneration . My published research include investigations of teratogens and other toxins , drugs with anti cancer and memory preserving properties , and the design , and characterization of biologically active synthetic peptides . After leaving the university , I have been working with medical devices . In CooperSurgical I have been working with medical devices for in vitro fertilization IVF treatment ; primarily various media for storage , handling , and culture of gametes and embryos . As a Regulatory Affairs Officer I have been working with registrations in the EU CE marking , Australia TGA , USA FDA , and China NMPA . More recently , as a Senior Scientist , my work includes the preparation of various technical documents supporting registrations in China , and the preparation and update of biological evaluation reports , biological risk documentation , and design history documentation for registrations in the EU under the Medical Device Regulation MDR . CURRENT POSITION Senior Scientist at Technical Operations , Life Sciences , CooperSurgical Inc. CONTACT 45 2614 6036 or pswalmod hotmail.com . Technologies : Xray;SPR;CD;NMR

Electron Microscopy Research Core Lead Research Scientist IV . Lead research scientist , team supervisor , grad student post doc mentor , and primary contact for projects involving electron microscopy at the University of Washington Institute for Protein Design . Research focus involves the structural electron microscopy and biophysical biolayer interferometry characterization of novel de novo protein nano materials , next generation vaccines , and antibody antigen interactions . Professional focuses involve the development and implementation of a high throughput training pipeline and workflow at an institution of 100 researchers requiring electron microscopy data collection , computational processing , and interpretation . . I am a lead research scientist with extensive experience in cryo electron microscopy , biolayer interferometry , and glycoproteomics . My PhD research focused on the structural , biochemical , and biophysical characterization of antibody antigen interactions , ion channels , and various other membrane proteins . At the Institute for Protein Design , I am currently the Electron Microscopy Core Leader , where I lead and supervise a team focused on the development and implementation of a high throughput electron microscopy research pipeline . My team is also heavily involved in high resolution characterization of next generation protein nano materials , protein based therapeutics , computationally designed nano particle vaccines , and epitope mapping of antibody antigen protein complexes .. Technologies : CryoEM;BLI

antibodies;proteins;characterization;interaction;structure

Senior Bioinformatics Data Engineer . Led , designed , and constructed internal data request system and analytical visualization tools to serve multiple departments Led , designed and developed MySQL database , docker , and API to consolidate project data from multiple departments , and setup periodic updates from files to database . . Experienced bioinformatician with 10 years working experience in Data Engineer BI Analyst with interest in application development using database , server side , and client side visualization to bridge bioinformaticians , biologists , geneticists , engineers , and various teams , to increase company wide productivity and efficiency . A self starter , fast learner , detail oriented , strong problem solver using automation platform with a combination of bioinformatics tools , scripts , and R Shiny Apps .. Technologies :

Postdoctoral Researcher . . Structural biologist with experience in drug discovery projects Expert in cloning , protein expression and purification biochemical and biophysical characterization structure determination using X ray crystallography and cryo EM Interpersonal skills : Experience in managing students capacity to build alliances outstanding coaching skills excellent written and verbal communication skills . Collaboration in A ParaDDisE Anti Parasitic Drug Discovery in Epigenetics consortium a European commission s funded project X ray crystallography : Enormous experience in solving structures using X ray crystallography expert in crystallization , soaking , on site data collection and structure determination . Technologies : Xray;CryoEM

proteins;characterization;expression;structure

Bioinformatics Analyst Engineer . . My principal research interests lie in the systems biology modeling of metabolic and cellular signaling pathways , particularly bottom up biophysical approaches using statistical mechanics and non equilibrium thermodynamics , as well as integration of various transcriptomics , proteomics , metabolomics , and fluxomics datasets via machine learning to improve model predictive abilities . Other interests include genome assembly and annotations , genome scale network modeling , bioinformatics algorithm development and software engineering of integrative system biology tools . . Technologies :

Expert Scientist Project Chemistry Team Leader . . Current responsibilities : Project medicinal chemistry team leader . Key strengths : . More than 20 years experience as research medicinal chemist team leader , covering all stages of drug discovery on a wide array of biochemical target types and mechanisms : enzymes Bace1 , COMT , ATX , ion channels NMDA , GPCRs Orexin , Vasopressin , M1 , transporters GlyT1 , splicing modifier SMN2 addressing high unmet disorders . Strong drug hunting skills : direct or indirect contribution to the discovery of 8 clinical molecules including Bitopertin reached PhIII , GlyT1 inh . for Schizophrenia , Risdiplam in PhIII , SMN2 splicing modifier for SMA , Balovaptan in PhIII , V1a antagonist for autism , recognized by the 2017 Swiss Chemical Society , Senior Industrial Investigator Award . Successfull experience in the discovery of PET ligands for CNS targets : Discovery of 11C RO5013853 , . validated PET tracer for GlyT1 . . Strong experience in running external research collaboration projects . Passions : multi dimensional optimization , driving projects forwards together with multidisciplinary research teams , coaching junior scientists and project leaders . 73 published patent applications . 48 publications 18 as corresponding author . 15 invited lectures at major medicinal chemistry conferences . Technologies :

proteins;small molecules;screening

Scientific Advisor . At LIPOSOMA research we manufacture and provide liposomal formulations , specifically clodronate liposomes , control empty liposomes and fluorescent liposomes . Our team of specialists and support staff has successfully served thousands of research groups worldwide . www . LiposomaTechnology . com , www . liposoma . org . Since the early seventies , Nico van Rooijen has been involved in studies on the role of various lymphoid and non lymphoid cells in the induction of ' in situ ' immune reactions against different types of antigen in the spleen . Given the idea that new scientific developments are often preceded by new technology , it was decided to develop new techniques , if answering of the main questions in this research project was hindered by the absence of suitable methodology . So , double radioisotope autoradiography techniques were developed for the simultaneous detection of various lymphoid cells and antigens . A double immuno enzyme technique was developed that allowed the in situ localisation of specific antibody forming cells in combination with their further characterisation . The ' Liposome mediated macrophage suicide approach ' has been developed to reveal macrophage functions and is now widely used for studying the many roles of these multifunctional and evolutionary ancient cells . For publications , see . the Google scholar account of Nico van Rooijen . You tube : https : youtube . com c Clodronate . Technologies :

carriers;formulation

Principal Scientist . Here at AstraZeneca I currently have a very cool job : I find and implement new ways to engineer novel nanomedicines . Nanomedicines are important because they will allow us to treat previously undruggable diseases , cure diseases and create medicines such as vaccines more quickly . I work at the interface between cell biology and nanotechnology , using high throughput screening , automated rapid prototyping , robotic microscopy and artificial intelligence . I also lead platform and capability initiatives within image based cytometry and intracellular delivery and participate in many collaborative efforts , both internally and externally . Happily , this also includes supervision of projects up to the post doc level . . Hi Welcome to my LinkedIn profile I am an enthusiastic , innovative and passionate scientist with broad and extensive experience from industry and academia . I have worked with many different pathologies including asthma , neurodegeneration and pain , heart failure , diabetes and metabolic syndromes and , chronic kidney disease . Naturally this has included work with many target classes and techniques , but my focus is currently on cell biology and robotic microscopy in the context of nanomedicine engineering please see more below . Specialties : Image analysis cytometic and histological , multivariate statistics , high content screening , automation , assay development and technologies , target validation , regenerative medicine , neurobiology , inflammation , bioactive lipids , metabolism , Alzheimer 's , pain , GPCRs and receptor biology , enzymology and enzymes , ion channels , antibodies . . Technologies :

antibodies;idps;membrane proteins;proteins;engineering

Researcher PHD Student . Currently investigating substrate selectivity and protein protein interactions concerning the mammalian family of SLC26 membrane transporter under the supervision of Raimund Dutzler . . I have graduated from the University of Nottingham with a first class MSci degree in Neuroscience , during which I completed a one year studentship with the biotechnology company Heptares Therapeutics that specialise in structure based drug discovery . I am currently undertaking my PhD at UZH under the supervision of Professor Raimund Dutzler within the Biomolecular Structure and Mechanism group . During my PhD I have become learned wide range of techniques in both soluble and membrane protein biochemistry . Furthermore I have advanced my skills in alternative areas , such as molecular biology and assay development techniques in order to better understand membrane transport processes . I also have gained experience in processing Cryo EM data for structural determination of challenging membrane proteins . Outside of my research , I teach regularly to groups of 10 15 students in practical classes to aid their understanding of key scientific concepts . Additionally , I have also supervised masters students undertaking research alongside my day to day tasks .. Technologies : CryoEM

membrane proteins;proteins;small molecules;interaction

Sr Scientist . DNA encoded Library selection Target selection . Enthusiastic and self motivated researcher with 10 years of experience in managing multiple scientific projects using strong analytical and problem solving skills . Excellent communication skill demonstrated by 10 publications in peer reviewed journals , 9 conferences and 8 invited talks . Advance level biochemical and membrane protein biochemistry skills along with experience in Cryo Electron Microscopy , single particle reconstruction resulted in high resolution structure of a challenging immature ribosomal particles , helped our group in securing 1.3 million funding in the form of R01 grant . Excellent interpersonal and leadership skill developed by interdisciplinary collaborations across 3 different countries , worked closely with 5 cross functional experts .. Technologies : CryoEM

membrane proteins;small molecules;interaction;structure

Research Fellow . . Physics PhD with 8 years experience creating mathematical and computational models of various biophysical systems using differential equations and Monte Carlo simulations . Strong analytical skills : Extensive experience performing Bayesian statistical analysis , programming in MATLAB 9 years , Python , Mathematica . Strong verbal and written communication skills : Extensive experience teaching courses to scientists and non scientists and explaining modeling concepts findings to teams of biologists . Wrote research manuscripts . Designed and taught high school and college science curricula , tying in current research and the scientific method , amazing experiments and jokes . Technologies :

Clinical Bioinformatics Director . Biomarker discovery , extended indication , and patient selection related to Niraparib PARP Inhibitor Characterization of NGS based genomic signatures for homologous recombination deficiency HRD and DNA damage response and CDx development Machine learning based expression subtype and clustering and immune profiling , and its application to a biomarker discovery and a single sample subtype classifier predictive for clinical response Leader in the pre conference workshop of PARP and DDR inhibitors summit 2020 Title Computational Techniques for DDR Therapeutic Development . Scientific professional with comprehensive research and project experiences in cancer genome analysis and industrial experience in drug development . Expert in computational and statistical analysis and data mining of next gen sequencing data . . Technologies :

PHD . Solving membrane protein structure using Cryo EM . . Technologies : CryoEM

membrane proteins;structure

. . Researcher in computational biophysics . Interest in simulations of membranes , membrane proteins , ion channels . Specialties : Molecular modeling , statistical modeling , structure function relationship . Technologies :

Principal Scientist . Creating genetic tools for the research and diagnostics markets . . Bioinformatics and Computational biology Phd with extensive background in genomics , algorithm development , data analysis and software development . Proven ability to create and implement novel methods for genome interpretation , spanning multiple genomic assays and next generation sequencing methods . Experience working with diverse research teams and engaging in cross functional collaborations with engineering , marketing , business development and product teams . . Technologies :

Senior Scientist . . I 'm a leading computational methods developer in cryo electron microscopy and in situ structural biology .. Technologies : CryoEM

Postdoctoral Researcher . After finishing my PhD , I am working at Max Planck institute for Multidisciplinary sciences as a Postdoctoral Researcher on High Resolution structure determination of Protein using X ray Crystallography technique . I am also involved in the development of techniques and technology for this high resolution data acquisition . My curiosity is pushing me to understand how much information can be extracted from Protein structures at high resolution and how much information is correct without bias . . . Technologies : Xray;CryoEM

Sr BioAnalytical Scientist . Management and troubleshooting of pre clinincal and clinical PK and immunogenicity assays and of bio assays related to CMC for the development of Antibody Drug Conjugates ADCs . 1988 2002 : Experience in Cell Biology and Immunology areas , both fundamental and applied , as PhD Postdoc . . 2002 2005 : Experience in and scientifically responsible for two human antibody programs in industry as Scientist at Genmab . . 2004 2009 : Responsible for the development , qualification and transfers to CMOs CROs of all CMC related binding and potency assays and all pre clinical related PK and immunogenicity assays related to antibody programs . 2010 present : Responsible for the development , qualification and transfers to CMOs CROs of CMC related molecular and biological assays related to antibody and vaccine programs . . Technologies :

antibodies;developing;stability

Senior Principal Scientist . Process development and structural characterization of polysaccharide , proteins , glycoconjugate and other bio molecules . . Researcher with experience in process development for clinical drug manufacturing : Antibody drug conjugates Oncology , glyco protein conjugates Vaccines and Nanoparticles . Managed and contributed to structural biology and protein chemistry projects , including drug development . Expertise in protein chemistry , molecular biology , small molecule fragment based screening , and protein purification downstream and characterization . Six years of research experience in polymer organic chemistry . Expertise in process development using NMR spectroscopy as analytical tool . Key contributor to synthesis and structure function studies of macromolecules such as proteins , polysaccharides protein ligand complexes , peptides , drug screening and polymers using NMR Spectroscopy , bioinformatics and other bio analytical techniques . Adept at identifying scientific problems , forming hypotheses , designing experiments , conducting scientific studies , analyzing data and communicating results . Expertise in usage and maintenance of high field NMR spectrometers equipped with cryoprobes . Able to manage and contribute to high performance teams that achieve organizational objectives . Forge strong relationships with internal external stakeholders . Published 60 peer reviewed papers , H index : 24 ; 1469 citations , many related to project accomplishments . Gifted mentor and coach . Specialties : Process development , Tech Transfer , Drug manufacturing , Bioconjugation , Structural Biology , Protein Chemistry , Nanoparticals , Polymer characterization , High Throughput small molecule screening , NMR spectroscopy . Chromatography : affinity , HIC , IEX , SEC , AUC , CD , Fluorescence Spectroscopy , SPR and BioLayer Interferrometry .. Technologies : SPR;AUC;NMR

antibodies;biologics;carriers;proteins;small molecules;characterization;developing;screening;structure

Postdoctoral Research Fellow . . After PhD training in stem cell biology and cryo EM , I 'm moving onto the neuroscience field and working on mechanisms of mechanosensation in physiology .. Technologies : CryoEM

Bioinformatics Scientist . . Bioinformatics researcher at Massachusetts General Hospital and the Broad Institute . Developing computational pipelines to resolve structural variants from next generation sequencing data with a focus on populations suffering from neurological developmental disorders .. Technologies :

Principal Scientist Translational Science , Oncology . Translational clinical biomarker lead for Nuvation 's oncology portfolio small molecules . A versatile , articulate and solutions focused translational scientist adept in defining and conceptualizing action plans , aligning diverse scientific research teams and resources to achieve project goals . A team player with excellent time management skills , high degree of motivation and multi tasking ability with substantial contributions towards multiple scientific projects and manuscripts . Accomplished cellular , molecular biologist with additional expertise in computational biology , biochemistry and functional genomics . Successful translational science experiences include biomarker strategy , biomarker assay development validation and implementation to support various phases of oncology immuno oncology clinical development and patient stratification . Successful scientific experiences include using ML mathematical modeling to deduce and validate signaling pathways , GWAS and sequencing to identify hepatic PK PD and microgravity responsive genes . Technologies :

Principal Investigator . . Cryo EM structural biologist , who dedicates to solve disease related protein structures down to atomic level .. Technologies : CryoEM

proteins;structure

PhD Student . . Engaging protein chemist with excellent experimental skills spanning broadly within Protein Chemistry . I am currently looking for new projects that will allow me to unleash my passion for proteins , be it academia or industry . I am self motivated , structured and independent . I am also a devoted mother , an excellent baker of cakes and newly discovered gardening enthusiast , unsurprisingly springing from a deep appreciation of nature , both the macro and microscopic . I enjoy a good puzzle , both in private but also in my professional life . I have a long track record of working in research labs going back 12 years . I started my scientific career as a research technician inducing in me a love of the wet lab and an appreciation for traceability in my research and lab safety that has stayed with me throughout my academic endeavors . During my studies of biochemistry at University of Copenhagen and Imperial College London , I have learned that working hard in general pays off . Becoming a parent has taught me to also work smarter to accommodate the new set of priorities . Both BSc and MSc projects were carried out in the lab of Jakob Winther , resulting in a minor and a major co authorship . The projects and the following research assistant work focused on protein design , enzymology and a general application of protein structure function relationship . It gave me competences within basic molecular biology USER cloning and transformation techniques , recombinant protein expression and protein purification FPLC , SEC , refolding , precipitation techniques that I was missing from my previous job in application research . It introduced me to biophysical characterization techniques fluorescence , CD spectroscopy , calorimetry , 1D NMR , thermostability and allowed me to continue with assay development bioluminescence in vivo and ex vivo . I commenced on a PhD within structural biology , shifting to mammalian protein expression of membrane proteins . I have acquired valuable transferrable skills such as academic communication and project management . Being in a newly started lab allowed me to be involved in deciding on consumables needed for my research and establish good protocols for lab work including GLP and safety . I did also acquire a sizeable set of new specialist skills , none the least a large PhD course within Electron Microscopy EM and very good skills within Negative Stain EM and some experience with cryo EM . I am very partial to coffee and would love to get a cup if you have an interesting project for me . Technologies : CryoEM;NMR

membrane proteins;stability;structure

Scientist . . Driven by fundamental questions in cell biology , I gained broad expertise covering areas of glycobiology , lipid protein interactions , functional studies of transmembrane proteins . In my research , I combine the innovative approaches from molecular biology , biochemistry and surface chemistry with a range of unconventional biophysical techniques . Where possible , I watch the behavior of single molecules in action using high resolution microscopy . . Technologies :

proteins;interaction

Head Bioinformatician , Glasgow Molecular Pathology Node . . . Technologies :

Professor of computer science . . I am a professor of computer science at King 's College London , working in user centric data science and AI . I am also a Fellow of the British Computer Society FBCS and a former Turing Fellow . Before joining King 's in 2020 , I held positions at Southampton , Karlsruhe Institute of Technology KIT , Germany Semantic Technologies Institute STI Innsbruck , Austria . I 've contributed to more than 20 research projects , often as principal investigator or project lead . Currently I am the PI of two grants : the EPSRC funded Data Stories , which works on methods and tools to make data more engaging , and the EU funded ACTION , which develops social computing methods for participatory science communities . I authored more than 100 papers in semantic technologies , knowledge graphs , human and social computation . I was also the chair of the European and International Semantic Web Conference and of the European Data Forum , and I 'm chairing the AAAI on human computation and crowdsourcing HCOMP in 2020 .. Technologies :

Senior Scientist Gene Therapy Process Development . . Highly productive Gene Therapy and Biologics Process Development Scientist with experience in upstream process development , cell line development , high concentrated mAb formulation development , downstream purification , tech transfer , cGMP , and eight years of experience in genomics , molecular cell biology , and neuroscience with the strong background in pharmacology and technical proficiency . Authored several manuscripts and fellowships . Able to multitask with excellent interpersonal , collaboration and leadership skills .. Technologies :

biologics;developing

Associate Computational Biologist . . My skills are in the area of computer science , mathematics , and physics . I 'm currently working on applying techniques from computational biology to better understand the gut microbiome . Experience in machine learning , statistics , single cell RNA sequencing , spatial transcriptomics .. Technologies :

Scientist . Reducing Cap Ex of the patented technology for the recovery of critical metals . I am identifying cheaper material , optimizing chemical conditions and column operations . So far , I have been able to reduce Cap Ex by 4 times . . Biotechnologist with strong background and passion for antibody research . My research tool kit include MnAb , scFv , nanobody , and artificial protein . I have expertise in phage surface display library construction , selection , characterization , production and functionalization of antibody constructs and finally their application in material science as well as cancer therapy cancer diagnostic .. Technologies :

antibodies;characterization;engineering

Associate Principal Scientist . . Extensive theoretical and practical experience in the field of enzyme kinetics , including interaction kinetics using Surface Plasmon Resonance SPR focusing on protein small molecule interactions . Skilled in assay development optimization , data analysis and interpretation as well as visualization and presentation of interaction kinetic data . Also experienced in running FBS using SPR . Specialties : Enzyme kinetics , Interaction kinetics , Surface Plasmon Resonance , Protein Small molecule interactions , FBS , Protein expression purification . Technologies : Xray;CryoEM;SPR

molecular glues;small molecules;developing;interaction

Lead Scientist . Lead Scientist on the Kymata Atlas , a database characterising the information processing pathways of the brain and human nervous system , maintained by the University of Cambridge and MRC Cognition and Brian Sciences Unit . . Computational neuroscientist and mathematician working on human brain mapping .. Technologies :

Director , Computational Biology . . Skilled in machine learning on large datasets , data visualization and software design Fluent in Python , R , Java , C , C , Perl on multiple high performance computing platforms . Technologies :

Research Technician . Working on time resolved cryo Electron Microscopy with microfluidics , image and data analysis . . Technologies : CryoEM

proteins;structure

Associate Computational Biologist . . . Technologies :

Assistant Professor . . Experienced researcher with a demonstrated history of working in the field of pharmacology and structural virology . Skilled in cryo EM , X ray crystallography , structure based drug design and lead optimization , pharmacokinetics pharmacodynamics , viral vector transfection production transduction , protein biochemistry , and enzyme kinetics .. Technologies : Xray;CryoEM

proteins;interaction;structure

NEST project SME lead engineer . . I build tools and technologies for data scientist and machine learning researchers . Before joining Roche , I worked as a research associate at the Oxford Big Data Institute , at where my job mainly focused on malaria parasite genomes and statistical genomic researches using a lot of coalescent theory . On the side , I also worked as a research consultant at the BGI , where I was focusing on developing methods for data storage using DNA . I love programming Check out some of the open source tools at https : shajoezhu.github.io software .. Technologies :

Manufacturing Supervisor . . Radiologisch medewerker 5B. Biodistribution study of Somatostatin radiofarmaca , building html intranet site , rewriting and checking correctness of SOP 's for thin layer chromatography of radiofarmaca . Technician , fermentation at BioTech Operations , SDS PAGE analysis of product at QC , Pharmaceutical Development Manufacturing amp ; Sciences Active Product Ingredients Large Molecules LEIDEN , Cell culture fermentation , Tangential Flow Filtration and UF DF , Kation Anion Chromatography , Affinity Chromatography Prot A , Spectrophotometry , HPLC , Column Packing , Technology Transfer , Process Excellence , Lean Manufacturing . Specialties : MS Office , antibody fermentation and purification , Lean manufacturing . Technologies :

biologics;quality

Kempe postdoctoral fellowship . Targeting tumor stroma interactions in 3D organoid co culture systems . This cover letter and attached resume contain my previous and most recent research and teaching activities before joining the Translational Research Centre at the Umea Universitet Sweden . I completed my PhD degree in Cancer and Genetics in 2012 at the University of Barcelona Spain and initiated my postdoctoral training at Northwestern University Chicago , U.S. where I contributed to the identification of MED12 as a novel cancer driver gene in uterine leiomyoma . After moving to UK , I gained extensive experience in drug discovery and preclinical assessment of first in class apoptotic targeted therapeutics at both Institute of Cancer Research 2014 2016 and Centre for Cancer Research and Cell Biology Queen s University of Belfast 2016 2019 . In 2020 , I joined the Hematology and Regenerative Medicine HERM at Karolinska Institutet as a senior researcher specialist to therapeutically targeting undruggable transcription factors using a proof of concept proteolysis targeting chimera PROTAC and CRISPR Cas9 models in AML cells . Most recently , I accepted a Kempe fellowship at Umea Universitet to contribute to the screening of a SciLifeLab compound library in mouse and human PDAC organoids and preclinical KPC mouse models . The most relevant results have been published in peer reviewed journals such as Cell Death and Differentiation , FEBS , Modern Pathology , or Endocrinology allowing me to achieve a successful although still modest track record in projects and publications . Besides my strong background in academia and life sciences , working within multi disciplinary research teams in close collaboration with clinicians and industry i.e. Sprint Bioscience , Domainex have triggered an increasing interest in bringing innovation even closer to my most immediate career goals with special focus in the area of next generation therapeutics and identification of novel biomarkers for early detection in precision medicine . Finally , just to express my commitment to undertake supervision and managerial responsibilities to strength my current leadership skills , and to be an active and supportive member to the team . Yours sincerely , M Espona Fiedler , PhD , FHEA . Technologies :

molecular glues;developing;screening

Senior Laboratory Tecnician . Target Discovery Automation Team Screening . . Technologies :

Associate Director , Lead Data Architect . . . Technologies :

Scientific Community Engagement Manager . . Microbiome scientist with a computational background and experience communicating science to a wide variety of constituencies . Experience with public policy and science outreach . Passionate about advancing the democratization of science and equitable research .. Technologies :

Manager , Bioinformatics . Leading a team that finds meaning in the largest genomics datasets in the world . The bigger the better . . Technologies :

Senior Manager , Commercial Bioinformatics . In this multidisciplinary cross organisational role I focus on coaching and developing my team which thrives on collaboration , whilst continuing to maintain the highest level of customer success . I lead a team of scientists with diverse skill set solution architects , developers , trainers working within commercial bioinformatics division . My team provides : Second level support to internal and external customers in EMEA . bio informatics professional services and implementation of best in class bioinformatics solutions to key clients . Ecosystem strategy development management for Illumina informatics portfolio . Pre sales subject matter expert consultations as well as advanced bioinformatics training for external and internal customers . Project management for new product releases within Illumina bioinformatics product portfolio , including documentation delivery , staff allocation and readiness . Driving Commercial Bioinformatics team to comply with ISO13485 certification requirements . Key subjects of team engagement include large scale genomics projects , proof of concept studies for clinical and pharma clients , sample to answer deployments , rare and undiagnosed genetic diseases RUGD discovery , metagenomics , COVID surveillance , and other key applications of Illumina NGS technology . . I am a team leader and research scientist with over 25 years of experience in biotechnology , genomics , bioinformatics , pharmaceutical industry , evolutionary biology , and ecology . I can offer a unique mixture of skills : strong leadership skills , long experience of business and commercial work and programme management with great interest in driving any enterprise to a success backed by independent inquisitive mind of a competent scientist . Specialties Interests : scientific team management , bioinformatics , clinical scientific data management , molecular genetics , environmental marine research . Long experience of customer driven environment : client support , commercial programme management , professional services , marketing , training . Finally , I can offer three languages and a track record of excellent presentation and communication skills at international level events . . Technologies :

Director , High Performance Scientific Computing . Director , High Performance and Scientific Computing group responsible for delivery of Pfizer s enterprise high performance and scientific computing strategy , platforms , and services utilizing on premise and cloud computing infrastructure . . Strong technical leadership and hands on experience in architecting , designing , and implementing high performance computing systems in a life sciences biotech environment . Specialties : HPC Linux Clusters Cloud Services Hyper converged Infrastructure Storage Data Backups EMC SAN , NAS , NetWorker , Isilon Scale out NAS , DDN , GPFS , Lustre , Weka Enterprise Project Management Linux , UNIX , and Windows Systems Administration Virtualization VMware ESXi VSphere Data Center Operations Systems Integration Vendor Relations Technology Transfer . Technologies :

Scientist . . Masters in bioinformatics with strong background in biotechnology and biostatistics . Programming proficiency in Python , R , UNIX , AWS cloud computing . Research experience with NGS data analysis , cheminformatics and biotechnology : Proposed and developed a computational approach using python to analyze mass spectral data from non targeted analysis for detection of potential pollutants . Automated data collection from GC x GC TOF MS . Developed algorithmic and machine learning models in python to classify the spectral match . Improved the analysis time to 10 seconds for a job which took 3 months of manual effort . Demonstrated the significant impacts that microbiota from patients and staff have on the evolution of microbiome on ICU surfaces . Analysed 16S rRNA gene sequences using QIIME2 Performed quality filtering , dereplicating , and chimera filtering using the DADA2 . Performed taxonomy classification and produced alpha and beta diversity metrics . Assessed differential abundance at genus level and alpha diversity comparisons . . Technologies :

Postdoctoral Research Fellow . . My long term dedication to the field of structural biology endowed me to build up a deep understanding on protein structures and a profound expertise in a wide spectrum of major biophysical tools including EPR , X ray crystallography , and even cryo electron microscopy . The main theme of the projects that I have carried out throughout my research career is the structural basis of protein protein and protein ligand complex formation , which I believe can be my key strength in elucidating drug target interactions and their assessment . Furthermore , 7 years of my previous industrial experience in Korea provided me a good chance to learn an efficient way of communicating with coworkers and managing projects . As a matter of fact , I could experience a huge success in one of my projects that lead to the development of functional ingredients for a dairy product , which marked annual sales of 200 million at the opening year . As are described in my resume , the key strengths that I possess for success in this position include : Extensive experiences with a wide range of protein expression systems from bacteria to mammalian cells , and large scale purification techniques for both soluble and membrane proteins Expertise in X ray crystallography , EPR , and even in cryo EM study of membrane proteins Long term industrial experience with a history of a success in the product development of a functional dairy products Excellence in scientific communication , teamwork , and writing skills developed through the previous industrial experiences and project managements . Technologies : Xray;CryoEM

membrane proteins;proteins;expression;interaction;structure

Senior Bioinformatics Data Scientist . . I currently work as a Senior Bioinformatics Scientist at GRAIL Inc , developing bioinformatic approaches to deliver insights for early cancer detection from targeted methylation sequencing data . Previously , I was a Computational Biologist at AncestryDNA , where I developed and applied genome scale methods to understand the genetic basis of human relevant traits . I have a strong background and working knowledge in Computational Biology , Genomics , Statistics , and Machine Learning . I am experienced at quickly learning and leveraging computational methodologies to analyze large scale data . I completed my PhD in the Joint University of Pittsburgh Carnegie Mellon PhD program in Computational Biology . I primarily worked on developing computational tools , in R and Python , based on molecular evolution to associate genotypes to phenotypes . I am interested in learning about and developing Machine Learning approaches aimed at expanding our current understanding of gene regulation . Google Scholar : https : scholar.google.com citations user B5pIfJcAAAAJ hl en Publons profile : https : publons.com researcher 1685048 raghavendran partha peer review . Technologies :

Director , Biophysics and Injectable Formulations . I 'm working with a great , dedicated group of scientists and lab techs , heading up a department , which has biophysics of biomolecules and formulation for injectable projects as core tasks . We have access to a wide range of state of the art biophysical instruments , including in house NMR and SAXS capabilities , and we work closely together with scientists within biology and technology internally at Novo Nordisk as well as with both industry and academic partners outside Novo Nordisk . . I 'm working with a great , dedicated group of scientists and lab techs , heading up a department , which has biophysics of biomolecules and formulation for injectable projects as core tasks . We have access to a wide range of state of the art biophysical instruments , including in house NMR and SAXS capabilities , and we work closely together with scientists within biology and technology internally at Novo Nordisk as well as with both industry and academic partners outside Novo Nordisk . On the personal level I am social , flexible , conscientious and I take a pride in delivering the best results possible within a specified time frame . I enjoy and am challenged by the many facets of people management . I work very structured and independently , I am able to keep a cool head under stress and I thrive with having a lot on my plate . I have good interpersonal skills and experience in interdisciplinary teamwork , and I have thee skills to comprehend and acquaint myself with new methods and topics quickly . I speak German B2 , English and Danish fluently , and I enjoy working in an international environment .. Technologies : NMR

biologics;developing;formulation;stability

Director Bioinformatics . . 9 years of pharmaceutical industry experience including biomarker and genomics data analysis of clinical trials , drug target discovery , and NGS based safety liability assessment 6 years of people management experience including managing Senior Scientist Scientist Associate Scientist as direct reports , hiring five PhD level scientists , and promoting three direct reports . Currently managing a team of 10 people . Strong background in bioinformatics with in depth knowledge of genetics , genomics , and molecular biology Extensive experience in single cell genomics Proficient in computer programming including Python and R , and experienced in C C and MATLAB Expertise in next gen sequencing method development and broad experience in molecular biology , mammalian cell culture , and yeast genetics Authored multiple peer reviewed publications , two patents , two patent applications , and research grants fellowships . Technologies :

Senior Vice President , Research Site Head . . With over 20 years drug discovery experience my focus at Boehringer is the discovery of new breakthrough chemical therapeutics for cancer patients . Drugging highly compelling but as yet intractable oncogenes such as KRAS and other Protein Protein Interactions is a major area of my scientific focus . Pushing the boundaries of what constitutes a small molecule therapeutic such as PROTACs is a necessity when pursuing such targets and an exciting part of my work with the BI team . Our philosophy is to always obtain X Ray crystal structures of protein ligand complexes to guide and accelerate drug candidate design . Innovative software development to power in silico drug design is another area of high interest in our research efforts . Design and synthesis are intimately intertwined in drug discovery and hence synthetic organic chemistry aimed to populate novel molecular topologies which complement unprecedented protein pockets is also a key area of my scientific interest . . Technologies : Xray

molecular glues;proteins;small molecules;interaction;structure

Pharmaceutical Technology Development PT D Graduate Associate . The Pharmaceutical Technology Development PT D Graduate Program at AstraZeneca is a two year program consisting of three 8 month placements within different departments of PT D. First placement : Analytical Automation team within Inhalation Product Development Second placement : New modalities clinical formulation team within Advanced Drug Delivery . Currently working as a Pharmaceutical Technology Development PT D Graduate Associate at AstraZeneca . Before that , I ve gained a MSc degree in Biotechnology and a BSc in Bioengineering from Chalmers University of Technology Gothenburg , Sweden . During my MSc , I ve specialized in Biomolecular Science , inflammatory research and bioinformatics . Research experience includes writing a one year MSc thesis regarding GPCR signaling and termination at the Department of Inflammation and Rheumatology at Gothenburg University . It also includes writing my Bachelor thesis on the use of CRISPR Cas9 in metabolic engineering of S. cerevisiae and an internship within mammalian cell line development at ATUM in Newark , CA .. Technologies :

Bioinformatics Scientist III Primer Design . to be completed later . I am highly analytical and accomplished professional offering rich experience in bioinformatics , genetics , mathematics , and programming . I have completed doctorate in Bioinformatics and Computational Biology from Iowa State University , Ames , IA . I am leveraging strong interpersonal communication skills for building and maintaining long term professional relationships with clients and stakeholders alike . I can work well under pressure in a deadline driven environment . Some of my key expertise are : Bioinformatics Analysis Research Development Ecology Computational Biology Complex Solution Development Sequencing Processing Gene Panel Design Throughout my career , I have been instrumental in developing DNA probe sets , developing NAVIFY Mutation Profiler , and creating multiple complex custom panels for numerous genomes for customers . I am experienced in collecting and analyzing NGS data to share insights with management . My meticulous approach guaranteed that routine tasks were always completed on time , whilst enabling me the flexibility to respond to any urgent or unforeseen situations that arose . Trusted by management for improving processes , minimizing product cost , launching KAPA HyperCap target enrichment probes , as well as designing bioinformatics tools and delivering concurrent fast paced projects As a tech savvy professional , I am proficient in Python , Perl , R , Unix Linux , Windows , and Macintosh .. Technologies :

Beamline Scientist . . I am a diverse researcher in the field of structural biology . I have a vast experience on crystallography and mass spectrometry of macromolecules and experience also on many different analytical methods HDX , TLC , NMR , DLS .. and protein production and purification . I 'm always keen to learn new methods and approaches , and broaden my knowledge in studying the structure and function of proteins . I am a great group worker and love to reflect my ideas on my coworkers , but I am also an independent researcher with her own vision . I am a dynamic leader and able to keep projects under control .. Technologies : SLS DLS;NMR

proteins;characterization;expression;structure

Principal Scientist . Lead the Membrane Protein Group , overseeing protein production , structure , research and technology efforts related to membrane protein targets . Enable small and large molecule drug discovery by designing and generating relevant protein reagents , supporting biophysical functional assays and performing structural characterization . Develop novel technologies to improve drug discovery and accelerate structural characterization , with a focus on membrane proteins . . I apply my expertise in biochemistry , biophysics , structural biology and protein engineering to increase our scientific understanding of ligand and protein structure function relationships and enable large and small molecule drug discovery against all target classes , with a particular focus on membrane proteins . My research interests are focused on studying protein complexes at or in the membrane , with the goal to uncover the molecular mechanisms that underlie essential signaling and transport processes in health and disease . I truly enjoy the multidisciplinary and collaborative approach that is required to successfully tackle any research or discovery project in my group .. Technologies :

membrane proteins;small molecules;characterization;expression;structure

Principal Scientist . . Email : arnabde2004 gmail.com open to consulting offers ; experienced consultant for expert networks ; please feel free to consult me directly . Conversation with Nature India : Hard work knows no boundaries http : blogs.nature.com indigenus 2014 02 away from home hard work knows no boundaries.html Inventor Drug Product Lead CMC Regulatory in multiple patents that are in advanced clinical trial Springer These s Award for ' outstanding PhD research ' nominated by Columbia University Young Investigator Award by American Peptide Symposium . Experienced scientist impactful patents and publications with mini MBA Rutgers University . Author of book : Peptide Based Drug Development Springer , foreword by Prof. Martinez Chairman , European Peptide Society Cover article EMBO Reports and Journal of Biomedical Materials Research Skills : Formulation : high concentration protein antibody ; lyophilization , small molecules , hydrogel , liposomes , oligonucleotides aptamers , nanoparticles , parenteral , sustained release ; excipient ; biophysical characterization of biologics monoclonal , bispecific antibodies , antibody drug conjugates ADCs , etc , peptide synthesis solid phase and PEGylation . Analytical : chromatography size exclusion , ion exchange , affinity , reversed phase ; LC MS , HPLC UPLC SEC , IEX , RP , HIC , SEC MALLS , DSC , DSF , ITC , DLS , zeta potential , viscosity , rheometry , injectability , UV spectroscopy , Biacore SPR , ITC , mass spectrometry . DMPK : pharmacokinetics , pharmacodynamics , i.e , PK PD ; MSD ELISA analysis , ligand binding assay , Gyrolab immunoassay , handling biological samples . Drug Delivery : Companion diagnostics , polymer ; freeze drying , transdermal , subcutaneous , microneedle technology . Protein Biochemistry : Protein expression bacterial and mammalian HEK and CHO cell lines , purification ; gel electrophoresis , SDS PAGE , western blots . Molecular Biology : Genome editing BAC based cloning , cell line engineering , transfection , mutagenesis , cell based assays , cell culture . Immunology , Inflammation and Oncology : mouse models , Flow Cytometry FACS ; immunohistochemistry , qPCR , gene expression , biomarkers .. Technologies : ITC;SLS DLS;DSC;SPR;DSF

antibodies;carriers;peptides;small molecules;characterization;formulation;screening;stability

Analytical Chemist . . More than six years of hands on experience in Analytical Chemistry backed by Synthetic Medicinal Chemistry including establishing experimental strategies and trouble shooting experience . PhD in Synthetic Organic Chemistry from State University of New York at Buffalo , USA . MS in Protein Engineering from The Department of Chemistry and Molecular Biology from Gothenburg University , Sweden . 8 years hands on experience with challenges of Medicinal Chemistry in Lead optimization and Lead generation . Design development of multi step synthesis for natural biological and pharmaceutical materials as well as fine chemicals for over 20 years . International experience : Worked in USA and Sweden Expertise in various analytical and purification techniques including NMR , HPLC , LCMS , GC , GCMS , Karl Fischer Volumetric and Coulometric Titration , FT IR and others . Knowledge in cell culture , in vitro studies , western blot , real time qPCR , protein production , purification . Technical experience includes regular use of Microsoft Office , including Word , Excel , PowerPoint , also ChemDraw . Experience with Laboratory Information Management System LIMS , Bruker Topspin , Empower Chromatography Data System Waters , LabX. Also USPTO , Micropatent , espacenet EPO , SciFinder , Reaxys and other internal company databases . Experience with Electronic Laboratory Notebook ELN . Individual performer and team player Edited scientific publications . Technologies : NMR

Doctoral Researcher . A key feature of future battery generations will be their fast charging capability . Polymer based battery concepts have been increasingly discussed in recent years as an alternative technology with the potential to withstand high charge rates without compromising durability or safety . In my doctoral project , I investigate redox processes in a polymer based battery by in operando Electron Paramagnetic Resonance Spectroscopy . In addition to chemical properties , material specific properties such as the homogeneity of the redox processes during charge discharge cycles and the causes of cell degradation is also investigated . . I grew up in Northern India . After obtaining my B.Sc . Hons . Chemistry from St. Stephen 's College , University of Delhi , I moved to Bonn , Germany to complete my M.Sc . Chemistry degree from University of Bonn . In my master studies , I focused on modules which equipped me with a variety of experimental techniques . The main modules include Biophysical Chemistry , Organometallic Chemistry and Magnetic Resonance Spectroscopy . During my Master thesis , I specialized in Biological High field magnetic resonance , specifically the use of Pulsed Electron Paramagnetic Resonance to measure nanometric distances in proteins . My research interests revolve around structural studies and functional studies using magnetic resonance techniques . In my doctoral project , I am investigating redox processes in polymer batteries using Electron Paramagnetic Resonance techniques . My main focus is on Organic Radical batteries and elucidating the mechanistic features of cell degradation and stability . I intend to use the insights obtained from EPR studies to optimize Organic Radical battery setups .. Technologies :

Bioinformatician . . Bioinformatician with 7 years experience : I graduated from Queen s University Belfast QUB with a BSc Hons in Mathematics and Computer Science . I remained at QUB to undertake an MSc in Bioinformatics and Computational Genomics . As part of my MSc project I worked with Dr Simon McDade and developed a ChIP Seq pipeline with particular focus on analysing p53 and p63 in breast cancer . After graduating from the MSc in 2016 , I spent several years working as a bioinformatician for the Internal Products team and the Commercial Bioinformatics team at Almac Diagnostics . There I developed internal bioinformatics analysis pipelines and provided computational data analysis support for a wide range of biomarker research and customer projects . I was also the lead analyst for the implementation of gene expression signatures for Almac Diagnostics claraT software . In 2019 , I returned to Queen s University Belfast as a bioinformatician in the Genomics Core Technology Unit . Here I am responsible for the development of analysis pipelines and delivering data analysis for customer projects .. Technologies :

Institute Scientist . . Genomic researcher with over 12 years of diverse experience in analysis of fungal pathogens and their interactions with diverse hosts . Wide leadership expertise including of a diverse computational team and of large international multi year collaborations . Deep knowledge of sequencing technologies and analysis methods for investigating genome content using assembly and annotation , identifying genomic variation , and profiling gene expression using RNA Seq . Highly productive multi tasker with a strong history of high profile publications . Exceptionally skilled in leading analysis and interpretation of microbial genomic data and collaborating with diverse teams of biologists and computer scientists .. Technologies :

Professor of Computer Science and DataLab Director of Translational Data Science . . Applied Data Scientist and Manager , with experience in modeling and analyzing Software Engineering , Health Data , Genomics , and Social Networks data . Director of Translational Data Science focus on Health Data research , and Co Director of DECAL , top software engineering research lab . Expertise : Data Science , Software Engineering , Statistical Modeling , Mathematical Modeling , Algorithms , Empirical Studies , Bioinformatics Computational Biology , Complex Networks . Have published more than 110 papers , garnered 7 paper awards , two test of time awards , and have been funded by NSF , USDA , FS , AFOSR , and DOD .. Technologies :

Computational Biologist . . I am a computational biologist with interests in genetics , transcriptomics , and development . I have directed projects studying the functional landscape of neurons Harris et al 2021 and the developmental trajectory of hematopoiesis in preparation . I made significant contributions to a project studying maize meristem development Xu et al 2021 and published software central to all of the above projects Fisher et al 2021 . I specialize in applying traditional statistical and machine learning methods in a robust meta analytic framework . I use skills in parallel , distributed , and GPU computing to process and analyze large scale genomics data .. Technologies :

Principal Scientist . . Since my Ph . D 2000 in the areas of Cell and Molecular Biology at Ume University , I have worked at AstraZeneca in roles such as Principal Scientist , Team Leader , Project Leader for projects in the Lead Generation phase and Process Improvement Project Leader . These roles have helped me to develop a broad understanding of the drug discovery process as well as team dynamics . My scientific interests are cellular assays in general e.g. cell line generation , assay development and compound screening and molecular pharmacology of GPCRs in particular . On a personal level , I am dedicated person with a strong passion to deliver and a team player enjoying to collaborate with colleagues .. Technologies :

membrane proteins;small molecules;interaction;screening

Senior Scientist I GDC . Organic synthesis : Synthesis of heterobifunctional small molecule as proteolytic targeting chimera PROTAC Late Stage Functionalization LSF and total synthesis of Natural Product . Small molecule synthesis SAR of therapeutic interest and as tool compounds MOA . Purification , analysis , characterization Author and coauthor of 3 scientific publications in international science journals . . Synthesis of heterobifunctional small molecule as proteolytic targeting chimera PROTAC Late Stage Functionalization LSF and total synthesis of Natural Product Organic synthesis of small molecule of therapeutic interest SAR and as tool compounds MOA Purification of recombinant proteins monoclonal antibodies characterization Synthesis antibody drug conjugates ADCs , human serum albumin HSA conjugates to therapeutic peptide , purification and characterization Successfully developed propriety technology as applied to site specific PEGylation enzymes and peptides , evaluation of biological activities Inventor of a chemical synthesis strategy for high complexity DNA library preparation Synthesis of non nucleoside NNI small molecules as potent inhibitors of hepatitis C polymerase Synthesis substituted adenine analogs as potent TLR7 agonists DNA , RNA synthesis , purification and characterization Author and co author of 3 international patents and 21 scientific publications Specialties : Organic chemistry , synthesis small molecules and natural product . Medicinal chemistry nucleoside analogs , antiviral immunostimulant . Antibodies proteins and peptides site specific conjugation ADC , rHSA peptide , PEGylation . Protein purification chromatography and characterization IEX , HIC , PRLP , SEC , affinity chromatography , DLS , SDS PAGE LC MS . Protein protein interaction affinity KD determination SPR . DNA , RNA , peptide synthesis . NMR , LC MS MS , SPR , DLS , HPLC IEX , RP , SEC , AKTA UNICORN . Technologies : SLS DLS;SPR;NMR

antibodies;molecular glues;peptides;proteins;characterization;interaction

Senior Principal Scientist , IMED Respiratory , Inflammation and Autoimmunity . . Specialties : Medicinal Chemistry , PROTACs , Peptides , Inhaled delivery , Antivirals , Structure based design , Drug discovery , Management . Technologies :

molecular glues;peptides;developing

Bioinformatician . Human Genome Project . Computational Biologist nearing 50 years of software engineering experience , the most recent fifteen years in bioinformatics . I love to work with new technology and cutting edge science . Specialties : Genome assembly , genome to genome alignments , multiple alignments , cluster computing operation , web site management , MySQL database administration . Technologies :

Manager , Computational Sciences . . A strong critical thinker with proven ability to effectively communicate insights from large , multivariate data sets to biological relevance . Distinct problem solving and innovative perspectives developed from over 20 years of hands on cross discipline experience in biotech research and information technology consulting . Specialties include : Genome assembly and annotation , Next Generation Sequencing NGS , transcriptomics RNA Seq , microarrays , comparative genomics and variant analysis , Big Data , machine learning neural networks , SVM , data visualization , High Performance Computing , Linux , Platform LSF , Perl , R .. Technologies :

SVP , Chief Science Officer . . . Technologies :

Deep Learning Scientist . Leveraging Artificial Intelligence and Molecular Biology to create new Cancer Immunotherapies . . Machine Learning and Computational Biology Biostatistics in Dr. Mona Singh 's research group at Princeton .. Technologies :

Senior Research Scientist . . . Technologies :

Biotechnology Professional , Project Manager , Adviser , Consultant in Life Sciences . LiSOS is a one man business ZZP er owned by Peter Steenbakkers . LiSOS delivers consultancy services in Operations Support and Laboratory Facility Management , especially in the fields of Biotechnology , Biology and Pharmacology research . The owner of LiSOS is also the inventor of a unique antibody technology that generates monoclonal antibodies from antigen selected B cells , using a combination of B cell culture and mini electrofusion J. Immunol . Methods 1983;163:33 40 and https : webdoc . ubn . ru . nl mono s steenbakkers p geneanfua . pdf . He can be hired for advice and support in setting up this technology as well . . Management experience : . More than 25 years supervisory experience managing up to 15 direct reports both in scientific research and in research organisation . Operations lead and staff member of several Biotechnology Departments serving up to 290 scientist . Broad experience in budget control of large departments , building management , capital investments , equipment management , purchasing of materials and equipment , and many other forms of lab support . In other words : the complete housekeeping of large scientific biotech departments . Led or participated in many complex projects including building of new lab facilities , initiating a new research site in Cambridge USA , worldwide Lab Resource Spend Synergy Team , and outsourcing of Asset Management . Led various reorganisations , renovations and removals of lab facilities . Decommissioning of MSD Research Labs in Oss and setting up new organisation for Life Science Park . Scientific experience : . More than 20 years experience in cell biology . Especially B cells , T cells and macrophages . Expert on Antibody Technology and inventor of the proprietary B cell culture mini electrofusion for the generation of hybridomas from antigen selected B cells . 16 publications in peer reviewed journals from which 7 as first author and 9 as a co author . Inventor on 4 patent applications . Specialties : . Organisation and operation of Biotechnology departments . Specialist on antibody technology . Cell biology of B cells , macrophages and T cells . Technologies :

Senior Scientist . . I am an experienced researcher with broad expertise in structural biology , membrane protein biochemistry and biophysics . Specialties : Membrane Protein Structure and Function multi protein complexes , ABC transporters , glycosylation enzymes Cryo Electron Microscopy Cryo EM Image Processing single particles , 2D crystals Cryo EM map interpretation and protein model building Project Management and Teamwork large interdisciplinary projects Communication Skills reports , presentations . Technologies : CryoEM

membrane proteins;characterization;structure

Project Scientist . . . Technologies :

Research Fellow . This BBSRC funded project involves bringing a novel piece of software to a fully fledged state . The software STR MM Synchronised Trace Recording In ImageJ and MicroManager aims to facilitate synchronous and asynchronous multi modal data acquisition for academic and industrial applications . . I am an enthusiastic individual and I feel no problem is too difficult , and I thrive on understanding complex systems . I have experience of several multidisciplinary projects involving scientific research and software engineering . Technologies :

Operating Manager IHC . Daily operation and management of 14 technicians and 6 academic supporters in a ISO13485 regulated environment . Upstream IPQC and performance titration of immunohistochemical IHC retail antibody products . Final QC release of IHC retail products , including Class III FDA medical devices Production , processing , and QC of control cell lines for Class III FDA medical devices Daily planning of QC tests and productions Securing and developing infrastructure that enable : o Continuous project and assignment prioritization within the team and in line with overall business strategy compliance , NPIs and production site transfer o Measurement of KPI for production on time Establish and implement Continuous Improvement culture Performance feedback , and salary conversations Securing individual development plans for employees Stakeholder management throughout the organization Site point off contact to external pharma partner . I enjoy working with people . Developing and coaching is inert to me , and I energize through the success of my employees . My leadership skills are founded on my empathic and logic personality , as well as my strong scientific background that enables me to understand the needs and problems of the organization , the department , and my personnel . By nature , I worked structured and enjoy the framework in a regulated environment . I m result oriented , a strong communicator and I have a positive mindset . I m capable of keeping the overview of highly complex tasks , structures , and requirements , and at the same time ensuring excellent collaboration and an area of trust . Trust , respect , and teamwork are pivotal values to me .. Technologies :

Process Development Scientist . . Highly motivated , flexible and adaptable self starter , with excellent communication skills , I have won numerous awards by competition . My latest project is a stimulating role , identifying food biomarkers in biological samples , novel metabolites , for personalised diets for health . Challenging roles such as my current role and the research project undertaken for my PhD demonstrate excellent problem solving abilities and innovation . A proven track record in vaccine development and fungal genomic and proteomic research , demonstrate technical , bioinformatics and analytical skills . Mastery of molecular methods in cloning , expression and purification of membrane proteins for immunisation of two mammals has been achieved . Systematic approach to very high level mastery of technical skills was demonstrated by development of novel LC MS MS methods as senior IT Tallaght and UM biology department expert . Interdisciplinary communication and liaison with academic and technical personnel necessitated by research project and previous roles in management and training are evidence of excellent communication , team working and team building and skills . . Technologies :

Associate Director Team Leader DMPK . Team leader for DMPK bioanalysis Strategic development of nucleotide therapy bioanalysis ASO , siRNA , conjugates Develop bioanalytical strategies for small molecule drugs , PROTACs , peptide protein drugs , conjugated drugs , advanced delivery systems Drug development for Rare Diseases and for cardiovascular , renal and metabolism Member of DMPK leadership team LT . . Technologies :

molecular glues;nucleic acids;developing;screening

Senior Principal Scientist . . Broad experience in applying protein chemistry , structural biology biophysics and chemical sciences to advance drug discovery programs in the biopharmaceutical industry . Expert knowledge : Structural biology biophysics , biochemistry , biotechnology , protein ligand interaction , NMR spectroscopy , chemistry , fragment based lead discovery , hit generation and validation , protein chemistry , protein expression and purification . Strong background in oncology , infectious diseases and immunology . Proven track record in academic and industry settings . Experience in leading functional area and drug discovery teams . Action oriented and quality focused with a sense of urgency . Experience in initiating , establishing and maintaining productive cross site and external collaborations . Technologies : NMR

proteins;small molecules;expression;interaction;screening;structure

Scientist Structural Biology . . I am a biotechnology professional with longstanding experience in protein biochemistry in both academia and industry . . My area of expertise is the recombinant production and purification of membrane and soluble proteins towards structural biology and drug discovery . I have key skills in setting up a screening and production purification platform for membrane proteins and membrane protein complexes , as well as for Nanobodies as tools in structural biology or as biologics . . I currently work in a medium scale biotech where I lead a team of research associates working in different therapeutics areas with the aim of discovering conformation sensitive nanobodies against GPCRs and GPCR G protein complexes . My main interests are currently project management and team leadership towards the discovery of biologics and the development of protein based tools to aid in SBDD . . Technologies : ITC

antibodies;biologics;membrane proteins;expression;screening;structure

Postdoctoral Research Fellow . Identification of small molecule or affimers that inhibit the formation of insulin receptor IGF1 receptor dimers as potential treatments for type 2 diabetes . I completed my MChem in Medicinal Chemistry at Newcastle University in 2005 before moving to Leeds to do a PhD designing small molecule inhibitors of Mur Ligases as potential antibacterial agents . I then spent four years in the same group 2009 2013 working on an EU funded project identifying modulators of number of different ion channels and membrane transporter proteins . In 2015 , I moved to the Leeds Institute of Cardiovascular and Metabolic Medicine to focus on research identifying modulators of new protein protein interactions involved in diabetes and its cardiovascular complications . I currently supervise 3 PhD students and a Postdoctoral Research Associate .. Technologies :

proteins;small molecules;interaction