COGNANO/AVIDa-SARS-CoV-2

AVIDa-SARS-CoV-2

AVIDa-SARS-CoV-2 is a dataset featuring the antigen-variable domain of heavy chain of heavy chain antibody (VHH) interactions obtained from two alpacas immunized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins. AVIDa-SARS-CoV-2 includes binary labels indicating the binding or non-binding of diverse VHH sequences to 12 SARS-CoV-2 mutants, such as the Delta and Omicron variants. Further details on AVIDa-SARS-CoV-2 are described in our paper "A SARS-CoV-2 Interaction Dataset and VHH Sequence Corpus for Antibody Language Models.”

Columns

AVIDa-SARS-CoV-2.csv / train.csv / test.csv

Column	Description
VHH_sequence	Amino acid sequence of VHH
Ag_label	Antigen Type
label	Binary label represented by 1 for the binding pair and 0 for the non-binding pair
subject_species	Species of the subject from which VHH was collected
subject_name	Name of the subject from which VHH was collected
subject_sex	Sex of the subject from which VHH was collected

antigen_sequences.csv

Column	Description
Ag_label	Antigen Type
Ag_sequence	Amino acid sequence of antigen

Links

• Project Page: https://avida-sars-cov-2.cognanous.com
• Code: https://github.com/cognano/AVIDa-SARS-CoV-2
• Paper: https://arxiv.org/abs/2405.18749

Citation

If you use AVIDa-SARS-CoV-2 in your research, please cite the following paper.

@inproceedings{tsuruta2024sars,
  title={A {SARS}-{C}o{V}-2 Interaction Dataset and {VHH} Sequence Corpus for Antibody Language Models},
  author={Hirofumi Tsuruta and Hiroyuki Yamazaki and Ryota Maeda and Ryotaro Tamura and Akihiro Imura},
  booktitle={Advances in Neural Information Processing Systems 37},
  year={2024}
}