Accordingly, a decision was taken that combina tions of Oestrogens and Progestins may be continued for pregnancy test but a warning to the following effect was 474 asked to be put on the package as also in any other promo tional literature regarding the drugs: "Warning: There is some evidence to show that hormonal preparations when used during preg nancy may lead to foetal abnormalities and as such these should not be used during pregnancy or for pregnancy diagnosis." The Director General of India Council of Medical Research communicated the following recommendations: "Fixed dose combinations of oestrogens and progesterone may be totally banned in the country even for the treatment of secondary amenorrhoea as other, substitutes are avail able in the market for management of secondary amenorrhoea. ' ' On the basis of same the Ministry of Health took a decision to ban fixed dose combinations of these medicines in the country and cut off dates for manufacture and sale were fixed as 31st December 1982 and 30th of June 1983, respec tively.