He died at Innsbruck from a stroke in 1765; his wife pledged the rest of her life to mourning him, while co-ruling with her son, and Francis' imperial successor Joseph II.
Ta suri Innsbruckis aastal 1765 insulti; tema naine tõotas teda oma ülejäänud elu leinata, valitsedes samas koos oma poja ja François' keiserliku järglase Joseph II-ga.