Greek-speaking communities of the Hellenized East were instrumental in the spread of early Christianity in the 2nd and 3rd centuries, and Christianity's early leaders and writers (notably Saint Paul) were generally Greek-speaking, though none were from Greece.
Kuigi kreekakeelsed asundused hellenistlikus idas olid kandva tähtsusega varase kristluse levimisel 2. ja 3. sajandil ning mitmed varased kristlikud juhid ja kirjutajad (eelkõige Püha Paulus) olid kreeka keele kõnelejad, ei pärinenud keegi neist Kreekast.