In the early 20th century, this controversy was resolved when it became understood that complement can act in combination with specific antibodies, or on its own in a non-specific way.
20. sajandi alguses sai see vaidlus lahenduse, kui mõisteti, et komplement võib käituda nii spetsiifiliste antikehadega kombineerudes kui ka omal mittespetsiifilisel viisil seondudes.