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Q:Pancreatic islets were isolated from a healthy, non-diabetic donor to perform an experiment to look at insulin secretion inhibition. Compounds would be added to separate wells containing the islets bathed in a high glucose solution for one hour. After one hour, the supernatant would be collected, and the insulin content would be measured with an enzyme-linked immunosorbent assay (ELISA). Which of the following compounds would result in the least insulin secretion when added to the islets??
{'A': 'Dobutamine', 'B': 'Isoproterenol', 'C': 'Tolbutamide', 'D': 'Clonidine', 'E': 'Glyburide'}, | urgent |
Mate is the most consumed beverage in South America. There is interest in expanding yerba mate sales into the old and new markets by promoting its health properties and energizing effects. The research study aims to explore Argentinian and Italian purchasing and consumption behavior and perception of yerba mate. The exploration includes agro-food chain stakeholders' views, and consumers' habits, perception, knowledge of yerba mate in relation to other market positioning caffeine-containing products. Data collection includes qualitative method, such as interviews with agro-food chain stakeholders, that is producers, processors, consumers, and quantitative consumer survey. Data collection was carried out in Argentina and in Italy. Results show that in Argentina yerba mate consumption is driven by habit and tradition, and in Italy yerba mate is mostly unknown. Consumers tend to drink yerba mate in Argentina and other caffeine-containing beverages in Italy to socialize, and as source of energy. Consumers have little awareness of yerba mate antioxidant properties. Yerba mate provides the energy of coffee drinking, and the taste and pleasure of tea drinking. Italian consumers' key challenge to yerba mate drinking is the longer time it takes, compared to the usual espresso. Italians perceive it as an energetic or relaxing beverage, with a consumption experience similar to tea and infusions. There is need to update commercialization strategy of yerba mate in Italy. | non-urgent |
INTRODUCTION: This study was undertaken to estimate the burden of morbidity associated with laboratory-confirmed influenza in children below 15 years of age. PATIENTS AND METHODS: Children presenting with acute respiratory infection and/or isolated fever at the Basurto University Hospital, Bilbao, Spain between November 2010 and May 2011 were included in this study (NCT01592799). Two nasopharyngeal secretion samples were taken from each; one for a rapid influenza diagnostic test in the emergency department, and the second for laboratory analysis using real-time polymerase chain reaction and viral culture. RESULTS: A total of 501 children were recruited, of whom 91 were hospitalized. Influenza diagnosis was confirmed in 131 children (26.1%); 120 of 410 (29.3%) treated as outpatients and 11 of 91 (12.1%) hospitalized children. A total of 370 of 501 children (73.9%) had no laboratory test positive for influenza. The proportion of subjects with other respiratory viruses was 145/501 (28.9%) cases and co-infection with the influenza virus plus another respiratory virus was detected in 7/501 (1.4%) cases. Influenza virus types were: A (H1N1 and H3N2) 53.2% (67/126); B (Victoria and Yamagata) 46.0% (58/126); A + B 0.8% (1/126). The median direct medical costs associated with each case of laboratory-confirmed influenza was €177.00 (N = 131). No significant differences were observed between the medical costs associated with influenza A and B. CONCLUSION: Almost half of the cases were influenza virus B type. The administration of a vaccine containing influenza A and B types to children below 15 years of age might reduce the overall burden of the illness. | non-urgent |
PURPOSE: Optimization of CT scan practices can help achieve and maintain optimal radiation protection. The aim was to assess centering, scan length, and positioning of patients undergoing chest CT for suspected or known COVID-19 pneumonia and to investigate their effect on associated radiation doses. METHODS: With respective approvals from institutional review boards, we compiled CT imaging and radiation dose data from four hospitals belonging to four countries (Brazil, Iran, Italy, and USA) on 400 adult patients who underwent chest CT for suspected or known COVID-19 pneumonia between April 2020 and August 2020. We recorded patient demographics and volume CT dose index (CTDI(vol)) and dose length product (DLP). From thin-section CT images of each patient, we estimated the scan length and recorded the first and last vertebral bodies at the scan start and end locations. Patient mis-centering and arm position were recorded. Data were analyzed with analysis of variance (ANOVA). RESULTS: The extent and frequency of patient mis-centering did not differ across the four CT facilities (>0.09). The frequency of patients scanned with arms by their side (11–40% relative to those with arms up) had greater mis-centering and higher CTDI(vol) and DLP at 2/4 facilities (p = 0.027–0.05). Despite lack of variations in effective diameters (p = 0.14), there were significantly variations in scan lengths, CTDI(vol) and DLP across the four facilities (p < 0.001). CONCLUSIONS: Mis-centering, over-scanning, and arms by the side are frequent issues with use of chest CT in COVID-19 pneumonia and are associated with higher radiation doses. | non-urgent |
How to reduce SGOT and SGPT enzymes , i have gone through the LFT and found SGOT are 109 and SGPT are 140. How to reduce them...what is the diet and what are the medicines as i have less money to consult a doctor in delhi who are charging more than 500 consultation fee as Gastro experts. | non-urgent |
In the management of a burn patient, what is the initial step? | urgent |
Will valium become more effective over time? I know it is supposed to work instantly, yet I have been going up and down on doses for a few weeks now as I dont want to be on them. I do ok taking 5mg at night for a week, and then try to stop, or lower the dose, and end up a few days later needing 20mg just to stop a night time anxiety attack. Then I drop back to the 5mg for awhile do ok for a week, and again try to lower or stop...and the cycle continues. Is it better to just keep taking it at 5mg daily no matter what and leave it alone for awhile...husband and some web sites say that valium will become more effective if I take it daily to build up the same level in my body. | urgent |
What is the recommended treatment for menopausal hot flashes? | non-urgent |
Hi, I feel i might have a penile yeast infection. The symptoms i have now are, 1. Dry skin that peels off near the penis head (looks flaky) and an itching sensation. 2. A couple more itching areas on the inner side of the thighs close to the groin area that is white and turns red sometimes on rubbing it incase of an itch. Could i take the ketaconazole medicine suggested all over the internet (diflucan). Please advise me on what steps should i follow next. | non-urgent |
My 5yo son has been having very loose stools every time he poops. He was in to see his pediatrician last Thursday & again this Monday. Xray revealed foreign object 2mm in size in his stomach last Thursday. On Monday, they did a follw up xray & saw that it passed. Bloodwork done & came back normal, one level indicating he s getting over a virus. Doctor has him off dairy, he s drinking lactaid for about a week to see if that helps w/ his belly aches. But he still has a white Puss, & yellow, loose stool every time he goes. If his bloodwork & xray are normal, this rules out anything cancer related? What should I keep watch for & report to doctor? Should I get sample? | non-urgent |
Hi ! I am a 40 year old lady with a history of lymphedemea {sp?) and cellulitis in my feet and legs, I have rexcntly been treated at a local vein and vascular clinic. They have been wrapping my legs in compressions until I can get compression stockings, On my right leg I am having pain with burning and stinging sensations. The area this is occurring in has been red and dark colored for sometime, I was wondering what is causing the pain and burning sensations | non-urgent |
What are the symptoms of Hyperlipidemia? | non-urgent |
I had a Hida scan where the nuclear tracer stayed in my gallbladder and didn't release into my intestines. I have upper right quadrant pressure and extremes nausea. Does the Hida scan mean my gallbladder is not functioning ? I have all the symptoms associated with biliary dyskinesia.....no stones have been detected. | non-urgent |
I have had a cold, mainly a cough since November. It was a cold, went away and came right back. I am not sure the cough ever really stopped. Now I have pain in the right side and back when I cough. I have no fever (I did during the main part of the cold) and my energy level is okay -not great but not terrible. I have to sleep sitting up even with Nyquil. Is there really anything I need to be concerned with? | non-urgent |
Whenever I cosume alcohol, even if it is just one drink at the most. I wake up with a quarter size lump above my left eyebrow. It happens every time I cosume any alcohol, and the lump is always in the same place. I m worried that it could be a sign of cancer or a tumor . I do not have the lump on my head on a normal basis, only after alcohol is in my system | non-urgent |
Hi think I got a virus that was going around office 3 weeks ago but am unable to shake it. I have moments of pain any where, bottom of my foot, in my eye brow, back of leg, in my ribs. Feel better when I rest apart from feeling occasionally sick. But as soon as I exert myself I feel really hot, start to sweat lots and feel really drained and ill. Is this still a virus? | non-urgent |
Hi I am Naz and I have a problem on skin just above left elbow. When I scratch on that portion or any cold cloth is kept I have no sensation, but when a needle is punched I can feel the sensation. Occasionally there is itching feeling also Doctors had carried out biopsy and the result was Section shows stratified squamous epithelium keratinising type with mild atrophy. Basal layer is normal. Dermis shows a few lymphocytes. No histiocytes seen. No granulomas noted. Could you please brief me what is the exact problem. Apart from this from couple of days I am suffering from severe neck pain, left shoulder, elbow and fingers are also paining. My height is 5 4 and my wirht is 63kgs. Please provide me the details what exactly happened with my skin | urgent |
I have been to a physio and have been given exercises to do as I suffer from lower back & buttock pain. She did sports massage & gave me exercises but my pain is worse. should i stop the exercises. I have degeneration of my lumbar spine and left sacriolliac joint overstrain, | non-urgent |
PURPOSE: Study associations between frailty, illness severity and post-discharge survival in older adults admitted to medical wards with acute clinical conditions. METHODS: Prospective cohort study of 195 individuals (mean age 86; 63% females) admitted to two medical wards with acute illness, followed up for all-cause mortality for 20 months after discharge. Ward physicians screened for frailty and quantified its degree from one to eight using Clinical Frailty Scale (CFS), while clinical illness severity was estimated by New Early Warning Score 2 (NEWS2) and laboratory illness severity was calculated by a frailty index (FI-lab) using routine blood tests. RESULTS: CFS, NEWS2 and FI-lab scores were independently associated with post-discharge survival in an adjusted Cox proportional hazards model with age, ward category (acute geriatric and general medical) and comorbidity as covariates. Adjusted hazard ratios and 95% confidence intervals were 1.54 (1.24–1.91) for CFS, 1.12 (1.03–1.23) for NEWS2, and 1.02 (1.00–1.05) for FI-lab. A frailty × illness severity category interaction effect (p = 0.003), suggested that the impact of frailty on survival was greater in those experiencing higher levels of illness severity. Among patients with at least moderate frailty (CFS six to eight) and high illness severity according to both NEWS2 and FI-lab, two (13%) were alive at follow-up. CONCLUSION: Frailty screening aided prognostication of survival following discharge in older acutely ill persons admitted to medical wards. The prognostic value of frailty increased when combined with readily available illness severity markers acquired during admission. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s41999-021-00555-8. | non-urgent |
Just recently yesterday morning i noticed a slight bump on my penis close to my pelvis and was concerned that it was something serious. i first noticed it when it bled slightly, but after that it just remained a little swollen and had a small entrance mark resembling a cut. Up until now the swelling has gone down a little, i wasnt sure if it was a bug bite or maybe something more serious, what are your thoughts on this? | non-urgent |
The COVID-19 pandemic has created unprecedented challenges worldwide. Strained healthcare providers make difficult decisions on patient triage, treatment and care management on a daily basis. Policy makers have imposed social distancing measures to slow the disease, at a steep economic price. We design analytical tools to support these decisions and combat the pandemic. Specifically, we propose a comprehensive data-driven approach to understand the clinical characteristics of COVID-19, predict its mortality, forecast its evolution, and ultimately alleviate its impact. By leveraging cohort-level clinical data, patient-level hospital data, and census-level epidemiological data, we develop an integrated four-step approach, combining descriptive, predictive and prescriptive analytics. First, we aggregate hundreds of clinical studies into the most comprehensive database on COVID-19 to paint a new macroscopic picture of the disease. Second, we build personalized calculators to predict the risk of infection and mortality as a function of demographics, symptoms, comorbidities, and lab values. Third, we develop a novel epidemiological model to project the pandemic's spread and inform social distancing policies. Fourth, we propose an optimization model to re-allocate ventilators and alleviate shortages. Our results have been used at the clinical level by several hospitals to triage patients, guide care management, plan ICU capacity, and re-distribute ventilators. At the policy level, they are currently supporting safe back-to-work policies at a major institution and vaccine trial location planning at Janssen Pharmaceuticals, and have been integrated into the US Center for Disease Control's pandemic forecast. | non-urgent |
Respected Sir , Does azithral 500 mg good for skin acne ? & how long should I take ? Doxynor & folcicrom can help for remove the patches on face ? & how long I should take it? | non-urgent |
Hi, my lower right wisdom tooth was removed 9 hours ago. I feel well with no pain just a tingling on the root. My tooth was so big and dentist took 1 hour to take it of the roots was like crabs arms around the bone. The neighbouring tooths root was also involved because of the sticking to the wisdom tooth.Is it a possibility to get infected? | non-urgent |
hi i had a tooth out and it would not clot and had to have it stitched. i was advised to go to my dr for blood tests - they foned today and said the coagulants were fine and i was to go back for some more blood tests - what else could they be looking for | non-urgent |
Hi Doctor,I want to speak to a gynaecologist I had my last period on 24th May 2014, and lasted till 29th. Me and my husband had sex on 30th and every alternate day we do have sex.I felt like vomitting a week later. I was tired all day. So took a pregnancy test but it was negative.We are planning to have a child.We have tried for 2 months but the result is negative Please suggest | non-urgent |
What to expect if I have Drug dependence (Outlook/Prognosis)? | non-urgent |
Hi my 3 month old daughter has been pooing 5/6 times a day since 48hrs ago. The colour is yellow which i m told is normal and its not excessively runny but is there anything to worry about. She is sucking her hands a lot which might be her starting to teeth. Should we be concerned yet. We also have been giving her water in between feeds to keep her de-hydrated. | non-urgent |
Hello, I m having a bad day. Last night I started to sneeze, I thought it was normal. But I guess wrong. When I went to school my throat was hurting me and my stomach, also I had a bad running nose. I told my dad, but he said it s just a cold. To be honest I don t even know if I have a cold or not. Please help. Thank you, doc. | non-urgent |
My wife 50 years old wakes up with stiffens entire back pain lower back right and left throbbing and occasionally lower left back sharp pain. The only thing that relieves pain is heat spray.stretching , yoga , heating pad chiropractor just seems to make it worse. | non-urgent |
I am a 70 year old (in 2 days) single male. Lately my hormones are raging. I have a persistent urge to masterbate. These sensations and feelings are constant and do not even need a sexual stimulus. I am a catholic and masterbation is forbidden...I have slipped due to the overwhelming need for release...and that causes me deep spiritual problems. I have tried cold showers..thought stopping techniques..exercise. What can I do? Please do not publish my name or email address publicly. Thank you. | non-urgent |
Hi, me & my husband is 32 & we both are trying for baby since 14 months......... complete hormonal profile is done, Ovulation studies and follicular monitoring is done, my husband's semen analysis is done &Also HSG, Hysteroscopy and laparoscopy is done.........and doctor said everything is absolutly normal..........try on every alternate day from 8 day to 26 day...........can we take Fertisure F for me & Fertisure M for my husband. | non-urgent |
Squashed my right leg big toe, while playing soccer a few times, redish black strait ions become a little yellow, twisted my ankle 2 weeks back and tied a creap bandage for couple of days, toe was numb on and off when I where shoes, now wAs swollen after a short 2 hrs flight, and numb | non-urgent |
I have had an MRI on my back and have a deteriorated disk between the L5 and S1 and am having problems with siatica. I have gotten my first epideral injection but it was administered at the S5. Shouldn t this have been given at the site of my problem instead? | non-urgent |
What are the symptoms of Granulomatosis with polyangiitis ? | non-urgent |
What is the name of the medication that acts as a melatonin receptor agonist, and what condition is it commonly used to treat? | non-urgent |
I am 40 years old, in very good health with no real medical problems. All my life, I have never been able to pull my foreskin back to expose the glans. I have always been self concious of it - knowing that it is not normal. I have had an ok sex life so far- but have not known any different so I wonder if this problem is detracting from pleasure during sexual intercourse. Also my current partner, although understanding - finds it a little odd. I would like to get something done so I can be "normal" but not sure what my options are. Have always been too ashamed to show my doctor - please help!! | non-urgent |
Who may be more sensitive to the side effects of benzodiazepines, and what are some examples of these side effects? | non-urgent |
hi... i m geting treated for infertilty... my doctor suggested me to take ovacare...i using the medician from last three months not still dint conceive....but my periods are regular now as i am suffering from overian cyst....please help me by gudeing | non-urgent |
What is the location and presentation of the sporadic form of renal cell carcinoma? | non-urgent |
Hi - i split the piece of gum between #20 and #21. i saw my prosthodontist yesterday, and he told me to use Chlorhexidine twice a day. He said not to rinse or brush afterwards (as he did in the past cause it can cause tooth discoloration. My concern is with the tooth discoloration. Is there an alternative solution of any kind so i heal the area without using Chlorhexidine? I greatly appreciate your help and wish you a happy holiday season. Many Thanks,Priscilla | non-urgent |
Hi Doctor, There is a deep tear on the inside of my mouth at the end of the jaw where the upper & lower jaw meet. It has some discomfort to offer me on opening the jaw. My mouth doesnt open fully. Please tell me if there is anything to worry. My age is 49yrs. I am 5 ft 5 inches tall. My weight is about 75kgs. I am otherewise fine having no concerns. Regards, Mamta | urgent |
I am 51, weight 125 lbs, and have the first sypmtoms of Rheumatoid Arthritis, mostly in the heels of my feet. The last couple of days, my knees are not to the touch. I can feel the heat radiating from them but I have no pain, redness or swelling. My hot knees occur several times of the day and last for an hour or so, sometimes longer. Is this more RA symptoms? What is my body (knees) telling me? | non-urgent |
Q:A 25-year-old woman with a history of moderate persistent asthma presents to the emergency department with tachypnea, shortness of breath, and cough. She also mentions that she has recently started to notice red flecks in the sputum that she coughs up. The vital signs include: temperature 36.7°C (98.0°F), blood pressure 126/74 mm Hg, heart rate 74/min, and respiratory rate 26/min. Her physical examination is significant for moderate bilateral wheezes and poor air movement. The forced expiratory volume-1 (FEV-1) is less than 50% of the predicted value, and she is found to have a concurrent upper respiratory tract infection. She is given oxygen, albuterol, and corticosteroids for her exacerbation, and she starts to feel better after a few hours of monitoring in the emergency department. She is ultimately discharged home on a 14-day prednisone taper. Which of the following is a side effect she could experience on this short course of steroids??
{'A': 'Emotional instability', 'B': 'Fat deposits in the face', 'C': 'Impaired wound healing', 'D': 'Cushing’s syndrome', 'E': 'Amenorrhea'}, | urgent |
What are the symptoms of Child physical abuse? | urgent |
SARS-CoV-2 is the seventh member of the family of coronaviruses that can cause infections in humans, termed as COVID-19, which is now a global pandemic Because it is a novel virus, considerable efforts and extensive studies are needed to fully understand its characteristics Its symptoms and severity range from mild to critical, depending on several factors, such as host susceptibility to the virus and their immune system, with the most common symptoms being fever, fatigue, sore throat and runny nose There is no clear treatment available yet, though several options are being explored, with research for vaccines being at the forefront Traditional Chinese Medicine may also be used as a treatment option Since this virus is similar to the SARS-CoV and MERS viruses, considerable insight can be gained from previous studies Although many patients recover completely, there are several factors that lead to poor prognosis This review summarizes the research carried out so far in terms of treatment options and prognosis factors associated with COVID-19 | non-urgent |
Hi. My 4 year old son was just diagnosed with a Coronary Artery Fistula. It is 1.3 millimeters in size. My doctor is awaiting other opinions at the moment since this is a rare condition. My son has had a full blood panel, blood gasses, chest x-ray and evaluated by an ENT for tonsils or adenoid abnormality. All the tests showed everything was good and within normal limits. However, his temperature seems to drop significantly at night time. It drops to 95 degrees. Tonight, I noticed 1 ear was 95 and was ear was 96 degrees. It was probably because the way he was sleeping. Although, it is still really low at night. A few times, his coloration looked off, almost a bluish color. His coronary doctor said the discoloration wouldn t be because of his heart since the blood pumping in that area was good and not blue. I was wondering why his temperature drops so significantly at night and also if surgery is needed for a fistula so small in size? | urgent |
My 37 year old daughter was first diagnosed with Bells Palsy, which she was given Veltrax and Prednisone for. That seems to have abated but she is extremely fatigued and her arms, legs feel heavy. She has had multiple blood tests, with her white blood count somewhat elevated. She just received a parvo virus test result that was positive. What treatment does she need, and does the extreme fatigue fit into . | non-urgent |
My husband was in the ER a week ago with a jaundice and phantom off and on fever. His bilirubin was 3.9 at that time, his ammonia level was also elevated (47.0). We left the er with antibiotics (Cipro) and lactolose. We have not been able to get him in to see anyone for a follow up until this coming Friday. My question is... he s having bouts of diarrhea 8 or more movements in a day. Can I cut back on the Lactolose? | urgent |
With the emergence of effective vaccines against SARS-CoV-2, the need to find the determinants for its correct distribution is created, with health personnel being an essential group where coverage must be ensured. MATERIALS AND METHODS: A cross-sectional study was conducted through an electronic survey that was distributed to health personnel in the state of Nuevo Leon, Mexico. Potential determinants for vaccine hesitancy were covered including their intention to be vaccinated against SARS-CoV-2. RESULTS: A total of 543 responses were collected from health professionals, which 30 (5.5%) of the subjects stated that they would reject SARS-CoV-2 vaccination. How well informed the subjects were was the most determining factor, where misinformation related to vaccination and COVID-19 was the most important cause of vaccine rejection. CONCLUSION: The implementation of educational strategies for health personnel are required. | non-urgent |
BEFORE MY MOTHER DIED. WE TOOK HER TO ER FOR LEFT LEG PAIN WHICH HAD BOTHERED HER FOR A WEEK. THINKING IT WAS JUST A CRAMP. I MASSAGED HER LEG AT ALL HOURS. AFTER TALKING WITH FAMILY DOCTOR. HE TOLD US TO TAKE HER TO ER. AT ER THEY FOUND THAT HER BLOOD COUNT WAS LOW 5 AND THAT HER PLATELETT LEVELS WERE CRITICALLY LOW ALSO. SO THE HOSPITAL ADMITTED HER. A FEW DAYS LATER I WAS CALLED TO THE HOSPITAL. THE HOSPITAL STAFF HAD GIVEN MY MOTHER TOO MUCH FLUIDS IN HER IV AND SHE WAS COMPLETELY SWOLLEN AND STRUGGLING TO BREATH. THEY SAID SHE HAD ASPIRATED PNEUMONIA. EVEN HER EYES HAD A FILM ACROSS IT FROM THE SWELLING. SHE WAS NOW ON OXYGEN, DIURETICS AND ANTIBIOTICS. PRIOR TO ENTERING HOSPITAL. MY MOTHER COULD TALK, LAUGH, SIT UP, SING, MOVE HER ARMS AND LEGS AND WAS TOTALLY AWARE. AFTER THE ASPIRATED PNEUMONIA, SHE NO LONGER COULD DO THESE THINGS. SHE WENT DOWN HILL FROM THERE. THEY TRIED BLOOD AND PLATELETT TRANSFUSIONS NUMEROUS TIMES AND SUBJECTED HER TO NUMEROUS SCANS. AT ONE POINT KNOWING OF HER RADIATION TREATMENT PASS. I ASKED DOCTOR IF SHE HAD LEUKEMIA. HE SAID NO. ABOUT ALMOST A MONTH IN THE HOSPITAL, THEY COULD NOT LOCATE PROBLEM, WOULD NOT TRANSFER HER, WOULD NOT CALL IN OTHER DOCTORS, TOLD ME, IT DOES NOT MATTER IF SHE HAD 5 MILLION DOLLARS WE STILL WOULD NOT DO THESE THINGS. THEY SENT HER HOME AFTER NOT BEING ABLE TO LOCATE PROBLEM. SHE WAS SENT HOME IN HOSPICE. WITH INSTRUCTIONS, NOT TO PROLONG LIFE AND NOT TO FEED HER. I WAS NOT TOLD THIS TILL RIGHT BEFORE SHE DIED. BY THEN IT WAS TOO LATE. SHE DIED 4 DAYS AFTER COMING HOME. THE DAY BEFORE SHE DIED, I FAILED TO RECOGNIZE THE SYMPTOMS OF DEHYDRATION. THE DOCTOR DID NOT ORDER A CHECK TO SEE IF THERE WAS BLOOD IN MY MOTHERS STOOL, EVEN THO SHE WAS APPARENTLY BLEEDING INTERNALLY FOR 3 WEEKS. THE DOCTORS WITH NO ANSWER SAID THAT ALL SYMPTOMS POINTED TO LEUKEMIA. THE SAME ILLNESS THE DOCTOR HAD SAID MY MOTHER DID NOT HAVE 2 WEEKS EARLIER. IN FACT WAS DEFINATELY SURE SHE DID NOT HAVE. HE REFUSED TO DO PROCEDURES ON MY MOTHER BECAUSE SHE IN HIS WORDS WAS THAT SHE WAS TOO OLD AT THE TIME 76 YRS AND THAT HER LOW PLATELETT COUNT MADE ANY INVASIVE PROCEDURES DANGEROUS.NEVEN THO IN CHECKING I HD FOUND SURGERY ON A PATIENT AS OLD AS 84 AND THE PATIENT IS OKAY NOW. I AM LEFT WITH SO MANY QUESTIONS. I NO LONGER TRUST THE DOCTORS OR THE HOSPITAL. I AM LEFT WITHOUT A MOTHER AND MANY UNANSWERED QUESTIONS. ( that is okay, no need to answer question. don`t have credit card ) $15.00 is a cheap price for advice from a doctor, but it does not matter. my mother will still be dead, no matter what you say. the question was for me, because I was not sure I did everything possible. I have been depressed and am contemplating punishing myself by killing myself. I failed to protect my mother. therefore I need to be punish. I just needed to know, if I did everything possible. sorry to have bothered you. ) | non-urgent |
Hello gd morning my wife she had black spot on the surface layer of tongue for almost 8 - 9 months treatment done but no cure. when she eat food it pain and that black portion has become little thin as compare to other part of tongue. Size of black spot is 1 cm round. please suggest me what to do? | non-urgent |
I saw a specialist about my kidneys after my GFR came back low after routine blood work. The specialist took my off one medication saying he was sure it was bringing my GFR levels down. Today I got a summary of my visit in the mail and he diagnosed me with Stage 3 chronic kidney disease. I ve had no other tests other than blood work and no ultra sound. Can he be wrong | non-urgent |
Dear Dr., my name is babu, 41y, i have been suffering with neck pain and later the pain expanded to right shoulder. I have taken little spicy food last two days, could it gastric pain, now no pain at neck, but little pain around the shoulder. This is the first time of this problem. Please could you suggest what is the reason and how to control? | non-urgent |
Autophagy is dependent upon lysosomes, which fuse with the autophagosome to complete the autophagic process and whose acidic interior permits the activity of their intraluminal degradative enzymes. Chloroquine (CQ) and bafilomycin A1 (BafA) each cause alkalinisation of the lumen and thus impair lysosomal function, although by distinct mechanisms. CQ diffuses into lysosomes and undergoes protonation, while BafA inhibits the ability of the vacuolar type H(+)-ATPase (v-ATPase) to transfer protons into the lysosome. In the present study, we examine the impact of CQ and BafA on the activity of mammalian target of rapamycin complex 1 (mTORC1), inhibition of which is an early step in promoting autophagy. We find each compound inhibits mTORC1 signalling, without affecting levels of protein components of the mTORC1 signalling pathway. Furthermore, these effects are not related to these agents’ capacity to inhibit autophagy or the reduction in amino acid supply from lysosomal proteolysis. Instead, our data indicate that the reduction in mTORC1 signalling appears to be due to the accumulation of lysosomal storage material. However, there are differences in responses to these agents, for instance, in their abilities to up-regulate direct targets of transcription factor EB (TFEB), a substrate of mTORC1 that drives transcription of many lysosomal and autophagy-related genes. Nonetheless, our data imply that widely used agents that alkalinise intralysosomal pH are mimetics of acute lysosomal storage disorders (LSDs) and emphasise the importance of considering the result of CQ and BafA on mTORC1 signalling when interpreting the effects of these agents on cellular physiology. | non-urgent |
My husband is under the care of 3 doctors and is being treated with 15mg of prednisone for over a week for polymyalgia rheumatica. His symptoms have only improved a little and I m very concerned. He has extreme bone pain in his knee area, extreme night sweats, low grade fever always, had a trunkal rash and has had a dry hacking cough. His sed rate is high, neutro s high, lymphos low WBC high Rbc low neut absolute high and will be seeing his rheumatologist again tomorrow. He saw PC today. With the rash and cough sounds more like Giant Cell and if so his dose seems low to me. Also could this be leukemia and what tests should we make sure he gets? Thank you....this has been a very long month and a very slow process for us....Jo | urgent |
hi madam/ sir, my wife aged 34 yr is old and suffering from negative thoughts. she is always thinking to loss her life by the means in which she do not want to bear any pain. earlier she was fully healthy person and this syptom has came in her life since last two years after an incidence of father heart attack kindly guid me for treatment in kolkata area. | non-urgent |
I'm taking cephalexin, going to have a tooth pulled in a few days. My dentist suggested breaking open a Benadryl capsule, making a paste to put on my tooth for the pain. It is helping the pain. My concern is this: Will the Benadryl interact badly with the nitrous oxide or laughing gas that he will give me when he pulls my tooth? & will Benadryl interact with the injections he'll give me in my gums to numb them? Also, can I take my antibiotics & Benadryl the day that he pulls my tooth? | non-urgent |
Hello doctor,I am trying to conceive but my husband and I did cocaine a week ago. How long should my husband and I wait to safely continue to try to get pregnant? How long until it is out of our system? How long does cocaine stay in sperm? Thanks in advance. | urgent |
The COVID-19 pandemic and its containment strategies have presented unique challenges to India's healthcare infrastructure. While a national lockdown initially resulted in the closure of all licensed liquor shops, it also made healthcare facilities dedicated to the treatment of substance use disorders challenging to access. Addiction treatment services have been functioning at limited capacity with a lack of consensus on operating procedures. In this article, we present actual case scenarios where lockdown affected substance use and the treatment process, and discuss the policy implications and considerations for both. | non-urgent |
Hi! I was told I have an enlarged spleen and elevated liver enzymes. I am a 26 year old male, 5 7 215 pounds. I also have low testosterone levels which I have been getting testosterone injection for for the past year. My AST is 62 and my ALT is 137. I was wondering what the causes of this could be and what treatments I could pursue. I am seeing a gastroenterologist tomorrow. Other than these, I am in good health. Could injections of Testosterone Cypionate cause this? | non-urgent |
Hi doctor, I am suffering from a chronic allergy. I have a frequent cough and cold. I am using Montelukast sodium and Levocetirizine. It prevents the symptoms. But when I stop taking it, the cough gets increased. | non-urgent |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is spreading worldwide with different clinical manifestations. Age and comorbidities may explain severity in critical cases and people living with human immunodeficiency virus (HIV) might be at particularly high risk for severe progression. Nonetheless, current data, although sometimes contradictory, do not confirm higher morbidity, risk of more severe COVID-19 or higher mortality in HIV-infected people with complete access to antiretroviral therapy (ART). A possible protective role of ART has been hypothesized to explain these observations. Anti-viral drugs used to treat HIV infection have been repurposed for COVID-19 treatment;this is also based on previous studies on severe acute respiratory syndrome virus (SARS-CoV) and Middle East respiratory syndrome virus (MERS-CoV). Among them, lopinavir/ritonavir, an inhibitor of viral protease, was extensively used early in the pandemic but it was soon abandoned due to lack of effectiveness in clinical trials. However, remdesivir, a nucleotide analog that acts as reverse-transcriptase inhibitor, which was tested early during the pandemic because of its wide range of antiviral activity against several RNA viruses and its safety profile, is currently the only antiviral medication approved for COVID-19. Tenofovir, another nucleotide analog used extensively for HIV treatment and pre-exposure prophylaxis (PrEP), has also been hypothesized as effective in COVID-19. No data on tenofovir’s efficacy in coronavirus infections other than COVID-19 are currently available, although information relating to SARS-CoV-2 infection is starting to come out. Here, we review the currently available evidence on tenofovir’s efficacy against SARS-CoV-2. | non-urgent |
Hi ..two days ago I was told afyer an x rsy and ct scan that I have lymphoma. ..all my blood tests r normal including hdl..I have no symptom s at all . tumour marker yests r negative....what kind of lymphoma do u thinkI have? I am worried and I can't wait to get your answer. . | urgent |
Gene-based delivery of recombinant antibody genes is a promising therapeutic strategy offering numerous advantages including sustained antibody levels, better safety profile and lower production cost. Here we describe generation of a recombinant antibody Fc-9E2 comprising a fusion protein between human Fc of IgG1 and a single-chain Fv derived from a hybridoma 9E2 secreting a mAb neutralizing West Nile virus (WNV). Fc-9E2 was shown to retain parental mAb's specificity and WNV-neutralizing capacity. Adenovirus-mediated in vivo delivery of the antibody gene resulted in sustained Fc-9E2 serum levels leading to abrogation of lethal WNV infection in an animal model. | non-urgent |
just flew home to ny from california on saturday, while walking outside on sunday night i got dizzy and felt my heart pounding. I do have congestion in my right ear(with ringing), and a history of ear infections as a kid. I continue to have these symptoms today. | non-urgent |
I seem to have been bitten by spider near my elbow last evening that appeared as two welts...now I have about 11 and they are appearing to travel towards my hand. okay never mind. I don t have paypaly or credit card. thanks anyway. have a good day. | urgent |
Several previous studies have described the psychological testing of transsexuals. | non-urgent |
I AM 46. Height 5.3.Weight 63kg. I had some simple problems .ThereafterI take daily rozavel 5, losakind 25 and flutee(flouxetine) daily as per doctors advice for last one yr. i got checked as normal check up. serum creatinine has increased to 1.80. Please suggest me which medicine should i drop which causes most on serum creatinine. | non-urgent |
hi doctor it is for my daughter she get like a gland back of her head on the left near the neck and i want to know if it can go with medicine and what can i give her i am worried about she has 8 yrs.please doctor help me.she don t have any pain just if you press it no additional syntoms. just like a gland | non-urgent |
Hi doctor, During masturbation I just rub the tip of the penis and not the entire penis. Is it a wrong way of doing? I do not get excited during sex and unable to ejaculate. Only, rubbing the tip of the penis gives me excitement. Also, two weeks ago, I have undergone circumcision as my foreskin did not retract. Before circumcision too, I have the same problem. Please help. | non-urgent |
I have been trying for my second baby for almost 20 months , had a miscarrage (blighted ovum) in April 2013, followed by surgical removal, after which my periods have never returned. Scans and blood tests all normal.slight bleed this month for a matter of hours. Have now been prescribed norethisterone to takedown for 7 days from what I believe will be day 21 of my cycle. Should I be using other contraception. Worried that I am taking ovulation tests at the same time and have just picked up an lh surge? | non-urgent |
Over past 5 days I have had sudden onset of vertigo and high blood pressure ranging from 150/98 to 160/100 now just took it in standing and it was 148/108. My Md said the vertigo could be giving me the high BP and gave me exercises for vertigo. Concerned. Have mild anxiety with prn meds, but not so stressed. Female 38. | urgent |
I was diagnosed with Tenosynovitis in my wrist after suffering with pain for 3 months .My Gp gave me a steroid injection which I have had in my other joints before.I have since developed intence itching around the wrist and it s quite red .What is causing this? | urgent |
My 39 year old fiance began injecting Sustanon 250 IM to rebuild muscle tissue in his shoulder which he has repeatedly broken/dislocated over the years. He complained of injection site for days after administration (in his greater glut or quad). He was switched to Decadron with better results as far as injection site pain. Of course, all of these steroids were obtained illegally via internet from an overseas source. He didn t taper his dose when coming off of his last week of injecting the Decadron and is now experiencing night sweats. He claims that these particular types of steroids do no cause roid rage . I beg to differ. I am a nursing student and would like a better understanding of how these steroids work. Is it true that the adrenal glands eventually shut down so that a sudden d/c of this Rx is very dangerous? I m concerned about his Potassium/Sodium levels. | non-urgent |
Hay. Am misan.I currently just noticed that I had wart growing in my private part. This happened about last month. Although I treated it and it fell off in less than three days. And now its back. I asked my doctor and he said it could be because I didn t finish my medication. But I feel otherwise and awful. Please help me | urgent |
In a pulseless patient, what is the preferred diagnostic method to determine ventricular tachycardia? | urgent |
I had all my teeth extracted about 3 weeks ago for dentures. There is a white discharge from one of the sockets and it's still painful-is this infection?I'm 52, 160 lbs, and received antibiotics immediately after extraction because there was some type of infection already. In general I feel better but some of the site is still extremely painful. | non-urgent |
Q:A 45-year-old woman has a 2-week history of increased anxiety, abdominal discomfort, irritability, and difficulty concentrating; she was robbed at knifepoint in a parking lot 3 weeks ago. She takes levothyroxine for hypothyroidism and uses an over-the-counter inhaler as needed for exercise-induced asthma. Her blood pressure is 140/80 mm Hg, and pulse is 100/min. Examination shows dry skin and hair. She is cooperative but appears anxious, glancing around quickly when a loud noise is heard outside the office. Leukocyte count is 12,000/mm3 , and serum thyroid-stimulating hormone concentration is 5.0 μU/mL. An ECG shows sinus tachycardia. Which of the following is the most likely diagnosis??
A:Acute stress disorder;B:Agoraphobia;C:Generalized anxiety disorder;D:Hypothyroidism | non-urgent |
I have a rash on my bottom, has been for 5 or 6 months now, comes and goes, a friend told me it might be herpes, I dont have the blisters but i do itch every once in a while?Im 53, 137 pds, 35 yrs of age, am healthy as of 6 months ago when checked by wight cat scan, etc.. | non-urgent |
Patient age nine years girl. patient suffering fromUrine burning and blood drops came since Five days I consulted urologist he given cefodoxim proxiletMedicin. Not responsible please give me Doctor.Impression=small urinary bladder diverticulumUrine albumin=2+Leucocytes 14-16/HPF | urgent |
Hi, Yesterday a hard lump appeared under my skin where the edge ofy nose meeting my cheek is supposed to be. It leaks clear fluid but doesn t exactly hurt unless pressed. It wasn t there when I washed my face yesterday morning and wasn t there when I left for work at 1215 but was there when I got home at 530 . it goes roughly half an inch high grow my skin and is roughly an inch and a half long. What is it? | non-urgent |
What is a Bartholin cyst? | non-urgent |
Individuals engage in a variety of behavioral responses to cope with the COVID-19 pandemic, from complying with or transgressing against physical distancing regulations, to stockpiling or prosocial behavior. We predicted that particularly descriptive social norms are important in driving pandemic-related behavior as they offer guidelines in times of insecurity and crisis. To investigate this assumption, we conducted a longitudinal survey with two measurement points (n = 1,907) in Germany during the spring of 2020. Results show that descriptive norms (perceived behavior of close others) positively predicted future transgression against distancing regulations, stockpiling, and prosocial behavior over time. In our analysis, we account for previous behavior as well as other potential predictors (subjective threat, personality). In sum, our findings highlight the power of descriptive norms in increasing compliance with pandemic-related regulations and promoting future prosocial behavior. [ABSTRACT FROM AUTHOR] Copyright of Group Processes & Intergroup Relations is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | non-urgent |
Background: This study assesses the diagnostic accuracy of antigen testing compared to RT-PCR in asymptomatic collegiate athletes and describes outcomes of a surveillance testing program.Methods: Quidel Sofia-2 SARS-CoV-2 Antigen Tests were performed daily prior to sport participation for high-risk of transmission (HROT) sports from September 29, 2020-February 28, 2021. Paired RT-PCR and antigen tests were performed at least once a week. Positive antigen tests were reflexed to RT-PCR.Findings: There were 1,931 athletes in 6 HROT sports. A total of 81,175 antigen and 42,187 RT-PCR tests were performed (including 23,463 paired antigen/RT-PCR surveillance tests). There were 346 athletes (17·9%) with a positive RT-PCR test during the study period. Of the positive RT-PCRs, 83 (4·4%) occurred on paired testing days. The clinical sensitivity of antigen tests varied with the frequency of RT-PCR testing and prevalence of COVID-19. With once-a-week PCR testing, the clinical sensitivity of antigen testing was 35·7% (95% CI: 17%, 60%) and specificity 99·8% (95% CI: 99·7%, 99·9%), after adjusting for school prevalence. Daily antigen testing was similar to PCR testing 2-3 times a week in identifying infection, however, antigen testing identified infection prior to the next scheduled PCR on 89 occasions. This resulted in a 234 days where potentially infectious athletes were isolated prior to when they would have been isolated with RT-PCR testing alone. Among athletes who had RT-PCR testing 4 times a week, daily antigen testing did not increase sensitivity. Two (14%) athletic-related outbreaks occurred but 86% of infections were community-acquired.Interpretation: Screening for asymptomatic SARS-CoV-2 can be successful using different strategies. Physical mitigation is important even with frequent screening.Funding Statement: This study was funded by Quidel Corporation. Declaration of Interests: Kimberly G. Harmon declares grants from American Medical Society for Sports Medicine for Outcomes Registry for Cardiac Outcomes in Athletes;grants from Pac-12 Conference as Research Development Director, she is also the President of the American Medical Society for Sports Medicine Foundation Board. All other authors have nothing to declare. Ethics Approval Statement: The study was considered exempt by the University of Washington Institutional Review Board. Data sharing agreements for data in the Pac 12 HAP were in place for all institutions. | non-urgent |
Hello doctor, I had an MRI performed on my brain due to my visual perception being off and not seeing and understanding my location correctly while driving.I did hit someone and almost got into a larger accident. The right side of my head feels like there is a cyst or something there. My skull on the upper back right side would feel sore, bruised when touching it. It felt like a cyst, or something was inside the brain beyond the skull. After the MRI, it felt like a large bubble has got released from that area bursting into my skull. After the bubble burst, about an hour after the MRI, the bruising feeling in my skull started disappearing. There is a feeling like something is in my head in the upper back right side radiating up and down into my neck. On the right side of my neck, sometimes I feel a pinch or swelling but mostly feels like a lymph node is swollen. The MRI showed that I have a meningioma and localized frontal atrophy. The atrophy looks horrendous to me, and I found a lightened area where I have pain but it is not on the right but left side. My questions are: Can you tell me whether a lightened area on an MRI could be an infection and not a tumor? As far as the atrophy is concerned, I have felt like my brain cannot create its energy for about 1 to 2 years. I was drinking a lot of sugar to provide energy but then started using supplements like acetyl carnitine which changes fat to fuel. I was under a lot of stress for several years and also was using a lot of anticholinergics like allergy medicine and antidepressants. I read that the brain will cannibalize itself for Choline. I take Choline now, but do you think my brain shrunk due to stress, not enough Choline, low blood pressure (not enough nutrients)? Would acetyl carnitine which helps utilize fat for fuel cannibalize my brain for fuel if I do not have enough glucose or ketones? Currently, I am on Lexapro 20 mg, Wellbutrin 75 mg and Spironolactone 25 mg. | urgent |
My nephew is suffering from TB & is admitted in hospital but not improving healt wise i feel that the docotrs are just trying different medicines he has pain in ribs evertime new medicine & new r&d on him please help me to go to the professional docotr who can solve that child problem 23 years age | urgent |
Objetiva-se com esta pesquisa compreender como a pandemia de COVID19 influenciou na vivência de atividades do lazer por meio da propagação de memes, nos seus temas e tipos, em páginas futebolísticas no Instagram. Trata-se de uma pesquisa de campo que teve como técnica de coleta de dados o diário de bordo, sendo delimitado como tempo de coleta os trinta dias anteriores e posteriores à nota de 16 de março de 2020 publicada pela Confederação Brasileira de Futebol, que suspendeu os campeonatos de futebol por tempo indeterminado, como medida de combate à COVID-19 no Brasil. Conclui-se que a pandemia de COVID-19 influenciou no aumento de veiculação de memes futebolísticos, redirecionando seus temas para outras manifestações da cultura brasileira e também alterou a propagação por seus tipos, com ênfase para os memes verbo visual e verbo audiovisual. | non-urgent |
My 5 yr old son woke up with red blotches on skin. It s almost all over his face and some of those areas look slightly swollen. There are also areas on his torso, arms, neck, and on one leg. They are slightly itchy, but do not have any bumps. thinking of trying a benadryll type cream to see if it is an allergic reaction to something. | non-urgent |
Hi I am just wondering is it safe to breastfeed while have severe case of fungal toenails. All toes are affected. I m hoping to breastfeed for 6 weeks and then try laser therapy. Is it safe to breastfeed or is there anyway it could pass to the baby through my system | non-urgent |
I was hit by a car in Aug. 2012 ,and which the end results was a broken leg. I had to have surgery,and now I no longer own my own bone,cause now it s titanium,from my knee to my ankle. My doctor told me that it may take me a year to walk again. What happened instead by the middle of September they emoved he cast ,and I was walking before Halloween .I am truly blessed for that ,because I have children. I have been doing fine and taking it easy trying to abou my regular activities ,but I still get discomfort in my leg, it has been almost three years now and now I feel my leg mus les squeezing against it really tight as I walk and again thats not safe,and now its starting to affect my other leg,do you think they removed the cast to early,or can pain medicine help. Thank you -Ouch :( | non-urgent |
hi my name is cryasta 23 im diaberic but im not that bad on September to a ten pound cutting borad fell on my right foot my foot is always hurting i have numbness tingling and throbbing on my foot and this happen at work i thought i was seeing at foot doctor but i was not i was seeing a orthopedics doctor he did an xray and an mri he said there is nothing wrong but before the mri he showed me a dark shadow covering half of my 4th toe but i still am in pain and hes making go back to work idk what else to do | non-urgent |
Hi, I hv just brought melacare forte cream and still not applied as i was sacred , my face skin colour has become very dark and lot of marks are there but if I m using this now and if I stop using after a month then will it darken my skin the same or worse, and the other thing how am I suppose to apply this on my face, and after how many minutes should I wash my face, i am 27yr old with a five year old kid | non-urgent |
Hi, I had a Root Canal treatment (1st Sitting) done. Doctor advised to take Ciplox-Tz along with IMOL Plus. From the start of the medicine course, I have been experiencing dizziness and discomfort. Online research suggest that Ciploz-tz (Ciprolfloxin) and should be not taken with and NSAIDs like Imol plus. Please suggest if this is correct.ThanksAnil | non-urgent |
Hi, may I answer your health queries right now ? Please type your query here...i have a girl baby .she is one and half year old she doesnt eat properly ..and frm 6 days she is not taking solid food .she is only on milk .plz advice me what should i do | non-urgent |
Hello doctor, Around a year ago, some red pimples started appearing around my mouth, chin, forehead, and my nose. These small red pimples create a red area when seen from far away because they are very small and inflamed. It never disappears. My skin always feels stuck and not flexible and with a mildly itchy or burning sensation. No matter how much moisturizer I apply, it does not help. I am using Eucerin atopic control moisturizer and a gel cleanser with Hyaluronan. I even tried using Metronidazole and tea oil, but again it did not help. I have also tried to stop using anything on my face for some days, but it stayed the same. I am 24 years old now, and I never had acne tendencies when I was a teenager, and my skin always looked very smooth. My birth control pill is still the same as it was when I first started taking it, which wad around ten years ago. I do not use steroid creams nor fluoride toothpaste. How can I get rid of this? It was not there before a year. I am attaching a picture of my face. Thanks. | non-urgent |
about a week ago i was walking up my stairs to get to my apt door when i hit my hand against the railling and my pinky went back,the next day i went to the clinic to get it x-rated and he told me it was not broken,so he tapered my two fingers together and told me to take tylinol for the pain and to put ice on it,i have done that plus i even put splinter on my pinky and also put a bandaged and still it does not help,also the pain worsen's alot more when i ether try to do a fist or even just pick something up as little a cup,can u tell me if it broken,fractured or sprained | non-urgent |
Hi doctor, I had sex for the first time. After that, I did not get my periods yet. I went to a gynecologist. She had taken my blood sample and it was negative. But, still I have not gotten my periods and it has been a week ahead. What could be the reason for my late periods? | non-urgent |
I got scratch on my face by nail , and the outer skin layer got removed.And then blood comes. Is there any way to treat it soon as i have some photography party after two days? I m from India, suggest me a fast treatment procedure. | non-urgent |
my alt is 62 and I have been drinking one shot of vodka every day. I have a fatty liver according to the sonogram. I take no medication. The Alt level was in the teens before I started taking voda. I stopped all alcohol. Should I expect the alt to go down? | non-urgent |
What is the recommended treatment for croup, also known as laryngotracheobronchitis? | non-urgent |