Newsgroup: it.discussioni.animali.cani
Titolo: Ricerca Cornell Mono-Criptorchidismo

Ricerca della Cornell University sul criptorchidismo:  si cercano
campioni da analizzare.
I laboratori del Baker Insitute for  Animal Health presso la Cornell
University, Usa stanno affrontando una ricerca sul monorchidisno e il
criptorchidismo nel cane. L'obiettivo della ricerca è individuare i
geni responsabili dell'anomalia al fine da poter mettere a punto test
per individuare i portatori. I geni implicati sembrano essere  circa
due-tre,  ricercatori chiedono a proprietari e allevatori di inviare
campioni di sangue di cani monorchidi o criptorchidi e dei parenti
(genitori, fratelli, sorelle…) anche se "normali". Per maggiori
informazioni è possibile contattare la dottoressa Dr. Meyers-Wallen
all'indirizzo e-mail 
vn...@cornell.edu
 .
Segue il testo dell'articolo completo in inglese.  (messaggio
inoltrabile, anzi più lo si inoltra meglio è...)
  In the laboratories at the Baker Institute for Animal Health,
Cornell
  University, Dr. Vicki Meyers-Wallen focuses upon inherited disorders
that
  affect canine reproduction. Our goal is to identify genes that have
a
  negative impact upon reproduction, with the final goal of producing
  practical tests to identify those carrying harmful mutations. The
long term
  goals are to reduce, and eventually remove, such deleterious genes
from
  purebred dog populations, thus improving the reproductive soundness
of
  purebred dogs.
  We are asking for breeders and owners to participate in our study by
  allowing us to collect blood samples from their dogs and related
dogs.
  Those interested can e-mail Dr. Meyers-Wallen at 
vn...@cornell.edu
 .
We are
  studying the DNA to find the gene mutations that cause
cryptorchidism
  (undescended testicles). Since this is the most prevalent inherited
disorder
  of the canine reproductive system, it would be very helpful to have
a test
  to detect carriers of these genes. Then breeders could plan matings
in which
  no cryptorchid offspring would be produced, while allowing the
offspring to
  receive other desirable genes that such carriers may have.
  To this end, we have recently initiated studies of canine
cryptorchidism,
  which is the failure of one or both testes to descend into the
scrotum.
  Unilaterally cryptorchid dogs have only one testis in the scrotum.
  Bilaterally cryptorchid dogs have no testes in the scrotum. The
undescended
  testes may lie within the inguinal area or within the abdomen. This
is an
  inherited disorder, and is inherited as a recessive trait. In the
dog, both
  testes normally descend into the scrotum by 2 weeks after birth
(even though
  one can not really feel them there at the time), but should be
detectable in
  the scrotum by 6 weeks of age.
  Based on the few pedigree studies in dogs and experimental studies
in other
  animals, testis descent in the dog is thought to be controlled by at
least 3
  genes, the identity of which are unknown. Recessive mutations in
such genes
  result in cryptorchidism. Delayed descent of the testes may be a
similarly
  inherited trait, as there is evidence in mice that mutations in 1 or
2 of
  the genes controlling testis descent in that species can result in
delayed
  testis descent. It has been shown in other animals, such as pigs and
goats,
  that the prevalence of cryptorchidism in herds can be reduced over
time by
  selecting against this trait. That is, cryptorchid animals and male
and
  female parents of cryptorchid animals were not used as breeding
stock. This
  approach has not been used extensively in purebred dogs. However, if
both
  male and female carriers could be identified by a practical test,
then
  matings of carriers could be more easily avoided.
  The recently published canine genome sequence allows us to study dog
genes
  more effectively. Using this information, we and our collaborators
studying
  human and mouse cryptorchidism, have performed pilot studies in
dogs. We
  have not yet found mutations causing cryptorchidism, but we need to
examine
  many more dogs, their related family members, and dogs of several
breeds. In
  further studies, we plan to include dogs from family lines that have
this
  problem, as well as a few lines that do not. All participants are
purebred
  dogs, but their identity and that of their owners is held in
confidence.
  That is, the identity of dogs and owners will be not be revealed by
the
  researchers at any time. Using DNA markers and linkage analysis
techniques,
  as we have in other projects, we plan to examine DNA for markers
that allow
  us to identify the chromosome location of genes responsible for
  cryptorchidism. Once the locations are identified, the DNA sequence
of those
  regions is examined more closely to find specific genes and their
mutations.
  An example of another project in our lab in which this type of
analysis is
  being used is our studies of inherited hermaphroditism (Sry-negative
XX sex
  reversal, visit our website at
 
http://bakerinstitute.vet.cornell.edu/research/meyers_wallen/meyers_wallen.htm
  Our final goal in this project will be to produce practical tests to
easily
  identify male and female carriers of this trait. In the end, it
would be
  very helpful to have a test to detect carriers of these genes so
that the
  breeder could plan matings in which no cryptorchid dogs would be
produced,
  and still have the benefit of other desirable genes that such
carriers may
  have. We hope that our research will benefit purebred dogs by
facilitating
  the production of reproductively sound lines of all breeds.
Cryptorchid dogs
  with a single testis descended, while of lower fertility, can
reproduce.
  However, like begets like. The use of affected dogs as breeding
stock will
  eventually lead to increasing numbers of unilaterally and
bilaterally
  cryptorchid dogs. The American Veterinary Medical Association states
that it
  is unethical for a veterinarian to surgically correct this condition
without
  also neutering the animal, to prevent treated cryptorchid dogs from
being
  deceptively presented as reproductively normal. Although medical
treatments
  have been proposed for this condition in the dog, there is no
evidence that
  any are efficacious. Neither surgery nor medical treatment will
alter the
  affected dog's genetic makeup. Thus, reproduction from affected dogs
and
  treatment of affected dogs may not be in the long term best interest
of the
  breeder, or the breed. Breeding of animals with late descending
testes is
  likely to produce more animals with this condition, and worse, dogs
in which
  the testes fail to descend at all. In the end, a test to detect
carriers of
  these genes should lead to fewer cryptorchid dogs and improve
reproductive
  soundness in all breeds
--
Nonostante abbia un setter 
e assomigli a un setter (bianco e arancio)... 
Non sono un setter, sono un drahthaar
e vi faccio fare la fine della nutria :-)
http://www.redsocks.it
 

 campioni da analizzare.
Fortunatamente non mi sono ancora mai capitati cucciolini senza le
palline... ^__^
Segnalo la cosa ai vet dove vado a far pratica.
ciao :o)
-- 
 Brina
http://mongioie.blogspot.com/
il sito ufficiale di idac: 
http://www.millenniumdogs.net/

palline... ^__^
Non sia mai che non possano fare almeno trenta figli ciascuno, eh?
:PPPPPPPPPP ;)
---
Ciao! | I miei cani online
Nicola| 
http://www.nikosystems.com

 :PPPPPPPPPP ;)
:oPPPPPPPPRRRRRRRRRRRRR!!!


ciao :o)
sě sě tu spamma :-)
rossella
