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5a032693-e7d9-4789-97a8-bd884b75c1b1
GPCR that does not act through opening of potassium channels is?
Muscarinic M2 receptor
Dopamine D2 receptor
Serotonin 5 HT1 receptor
Angiotensin 1 receptor
3d
single
Ans. D. Angiotensin 1 receptor* Four G protein gated inwardly-rectifying potassium (GIRK) channel subunits have been identified in mammals: GIRK1, GIRK2, GIRK3, and GIRK4. The GIRK subunits come together to form GIRK ion channels.* Activation of the IKACh channels begins with release of acetylcholine (ACh) from the vagus nerve onto pacemaker cells in the hea.* ACh binds to the M2 muscarinic acetylcholine receptors, which interact with G proteins.
Pharmacology
null
3af11fb3-6d3b-4542-9de0-5f4decd77160
what does not occur in 5'- 3'direction?
DNA repair
DNA replication
RNA editing
Transcription
2c
single
Ans -C- RNA editingIn rna editing editosome can edit only in 3- 5 direction, along with primary rna transcript.DNA replication goes in the 5' to 3' direction because DNA polymerase acts on the 3'-OH of the existing strand for adding free nucleotides.In transcription the complementary RNA is created in the opposite direction, in the 5' - 3' direction, matching the sequence of the sense strand with the exception of switching uracil for thymine.When the strand containing the mis-match is identified, an endonuclease nicks the strand and the mis-matched nucleotide(s) is/are removed by an exonuclease.
Biochemistry
null
8be0f11a-fb38-4996-95b7-b3fcf36de7c4
Which of the following diseases is NOT transmitted by it?
Kala Azar
Chandipura encephalitis
Babesiosis
Carrion's Disease
2c
single
The image is of SANDFLY, identifiable by the long, slender legs, lanceolate wings, branching of the second longitudinal vein, densely hairy antennae, legs, body and wings. Diseases transmitted: Kala Azar Sandfly fever Oriental sore Oroya fever Carrion's disease Chandipura virus Babesiosis is transmitted by the Hard Tick.
Social & Preventive Medicine
AIIMS 2019
358a3866-8fc2-405e-b7e6-383904748d15
A 56-year-old female presents with nocturnal pain in the right thumb, index and middle finger for the past 3 months. All of the following provocative tests can be performed for the diagnosis of the condition except :
Phalen's test
Finkelstein test
Tinel's sign
Tourniquet test
1b
multi
Ans. b. Finkelstein test (Ref. Maheshwuri 3/eNocturnal pain in the right thumb, index and middle finger for the past 3 months in a 56-year old female is highly suggestive of Carpal tunnel syndrome. Finkelstein test is used to diagnose DeQuervain's tenosynovitis, not the carpal tunnel syndrome.
Surgery
null
c254e7c1-e9d0-4cfc-8a9f-2a69b48961d4
An avulsed tooth which is replanted shows loss of lamina dura radiographically, high sound on percussion. The type of resorption is
Internal resorpton
External resorption
Replacement resorption
Cervical resorption
2c
multi
null
Dental
null
33b23fe7-afeb-4475-af4c-a9e250c82578
Which of the following is not a content of mesorectal fascia?
Inferior rectal vein
Superior rectal vein
Pararectal lymph node
Inferior mesenteric plexus
0a
single
Ans: A. Inferior rectal veinMesorectum is enclosed by mesorectal fascia, which is derived from the visceral peritoneum.Known as visceral fascia of mesorectum, fascia propria of rectum or presacral wing of hypogastric sheath.Upper rectum is derived from the embryological hind gut, it is surrounded by mesorectumdeg. Contents of Mesorectal fasciaSuperior rectal aery and its branchesSuperior rectal vein and tributariesLymphatic vessels and nodes along superior rectal aeries.Branches from inferior mesenteric plexus to innervate rectum.Loose adipose connective tissue down to the level of levator ani (pelvic floor).
Anatomy
null
b6960906-d735-47a0-b71b-aa8af6cd26b3
Which of the following is a false statement?
Acetaminophen does not have anti-inflammatory action
NSAIDs with least cardiovascular risk in Naproxen
Gastric irritation is more severe with NSAIDs compared to aspirin
Non selective COX-2 inhibitors are contraindicated in postoperative patients
2c
multi
Gastric irritation is most severe with aspirin. It can cause gastric mucosal erosion and ulceration leading to bleeding and perforation.
Medicine
AIIMS 2017
ccec60b1-80b6-4130-b1ab-8631cac2fa14
FNAC can not diagnose
Papillary carcinoma of thyroid
Follicular carcinoma of thyroid
Anaplastic carcinoma of thyroid
Medullary carcinoma of thyroid
1b
single
FNAC helps in diagnosis of- Papillary carcinoma Medullary carcinoma Anaplastic carcinoma Colloid nodules Thyroiditis FNAC cannot diagnose follicular carcinoma and Hurthle carcinoma
Surgery
null
4f393b71-3955-4db3-a376-99af5015b825
A couple comes for evaluation of infeility. The HSG was normal but semen analysis revealed azoospermia. What is the diagnostic test to differentiate between testicular failure and vas deferens obstruction?
Serum FSH
Karyotyping
Testosterone levels
Testicular FNAC
0a
single
Ans: A. Serum FSH(Ref. Ganong 25Ie p419, 425, 24Ie p427)Prior to initiating treatment for a couple, in whom the man has azoospermia, it is impoant to distinguish whether the lack of sperm in the ejaculate is from an obstructive or non-obstructive process.The presence of normal volume testes with bilaterally indurated epididymis and/or absent vas deferens will point to an obstructive etiology for azoospermia.A history of cryptorchidism in the presence of small or soft testes suggests non-obstructive azoospermia, especially if associated with an elevated serum (FSH) level.A decreased spermatogenesis leads to decrease in production of inhibin, which causes an elevation in FSH.
Physiology
null
dac67e00-7708-4533-a6da-38c259fe8403
Which Bone does not form the wrist joint
Radius
Triquetrum
Scaphoid
Ulna
3d
single
* Bones forming the wrist joint are: radius, scaphoid, lunate, triquetrum and other carpal bones.* The wrist joint is a synol joint between the distal end of radius and the aicular disc overlying the distal end of ulna and the scaphoid, lunate and triquetrum.* Ulna is not pa of wrist joint, only the overlying aicular disc is pa of the wrist joint.
Orthopaedics
AIIMS 2018
5d7ae586-3ecd-41a4-a172-d32ab3dc4f6a
Mass Drug Administration is not helpful for
Lymphatic Filariasis
Vitamin A Deficiency
Worm infestation
Scabies
3d
single
- Lymphatic Filariasis is treated with Diethyl carbamazine (DEC) (Or) a combination of DEC + Albendazole/ Ivermectin - Vitamin A deficiency - Prophylaxis- 2 lakhs IU to 1-6 years of age - Worm infestation - Ascariasis once every 2-3 months; it does not interrupt transmission but useful in reduction of worm load in community - Scabies - No mass drug administration done along with patient his/her family members should be treated not the whole community.
Social & Preventive Medicine
AIIMS 2019
90c375a2-63de-4f16-940c-5f8a08df0d8d
Ideal denture base material should not have
Sufficient strength
Dense and non-irritating surface
High specific gravity
Esthetically acceptable
2c
multi
null
Dental
null
41b7f0c0-744e-41fd-ae2b-13fc6a741347
In a patient with heart disease, which of the following should not be used to control PPH:
Methylergometrine
Oxytocin
Misoprostol
Carboprost
0a
single
null
Gynaecology & Obstetrics
null
1f9e0b7b-8eab-4fb0-a1c7-9ff074f3e1d8
Which of the following is not a feature of anaphylaxis?
Delayed reaction
Immediate reaction
Passive transfer by serum
None of the above
0a
multi
null
Microbiology
null
f94eef30-d8f9-4d40-866e-a89c7fbb7c7f
Drug not requiring dose adjustment in renal disease is
Aminoglycoside
Vancomycin
Calcium channel blocker
Metronidazole
2c
single
null
Pharmacology
null
9dbe9f17-d9ee-46fe-b3d3-8c6c19758be6
A research was undeaken by a group of psychiatrists and obstetricians to assess postpaum depression in mothers giving bih to male versus female children according to the Edinburgh depression scale (EPDS). What test should be used to compare the outcomes?
Student's t-test
Paired t-test
Chi-square test
Pearson's correlation coefficient
2c
single
Answer- C. Chi-square test Chi-square test- Comparison of two independent qualitative variablesA 'non-parametric test' of significanceUsed to 'test significance of association between 2 or more qualitative characteristicsUsed to compare propoions in 2 or more groupsUsed for non-Normal (non-Gaussian) distributions
Social & Preventive Medicine
null
863c894a-fa96-4875-bf3d-dd8d2460a21a
true is all except regarding intrafusal fibres
Nuclear bag fibres are lesser
Nuclear chain fibres are shorter and thinner
Secondary endings excited by chain fibres only
Primary endings excited by bag fibres only
3d
multi
null
Physiology
null
83cbb1ff-e31f-4eec-b198-b39874f05c2a
About zinc oxide eugenol all are true except
ZnO is converted to Zn(OH)2
Reaction is autocatalytic
Water is the byproduct of reaction
Dehydrated ZnO reacts with dehydrated eugenol
3d
multi
null
Dental
null
26124571-60c3-4509-9c33-981bc3b40054
Maculopapular rash is not seen in ?
Dengue
Rubella
measles
Zoster
3d
single
Ans. D. ZosterMaculopapular rashes are seen in:* Rubella* Dengue(febrile phase)* Measles* Chikungunya (acute infectious phase)* Erythema infectiosum* Zika virus* West nile virus* Infectious mononucleosis
Skin
null
d6e82b03-66cb-479a-950a-3f75ab8e99d6
A 6 weeks old baby presents with cough and cold for the last three days. Respiratory rate is 48/min. Patient is febrile, there are no chest retractions but wheezing is present. Which of the following statement is not true?
Antibiotics are not required
Child is suffering from pneumonia
Treat only wheezing
Treat only fever
1b
multi
Answer- B. Child is suffering from pneumoniaPneumonia:The World Health Organization has defined pneumonia in children clinically based on either a cough or difficulty breathing and a rapid respiratory rate, chest indrawing, or a decreased level of consciousness.A rapid respiratory rate is defined as >60 breaths/minute in children <2 months old, 50 breaths/minute in children 2 months to 1 year old, or >40 breaths/minute in children 1 to 5 years old.
Pediatrics
null
cf3f103b-e4d8-4f34-86aa-b69f3b31fe55
On laboratory investigations in a patient, LDL was highly elevated but the level of LDL receptors was normal. Which of the following is most probable cause?
Phosphorylation of LDL receptors
Lipoprotein lipase deficiency
Apo B-100 mutation
Cholesterol Acyl Co-A transferase deficiency
2c
single
Ans: C. Apo B-100 mutationIn Type Ila Familial hypercholesterolemia:Highly elevated levels of LDL with normal level of LDL receptors.Characterized mutation in ligand region of apoB-100.Differential diagnosis:"Familial Defective apoB-100 (FDB)"/"Autosomal dominant hypercholesterolemia (ADH) type 2":Dominantly inherited disorder.Clinically resembles heterozygous familial hypercholesterolemia (FH) with elevated LDL-C levels and normal TGs.FDB - Caused by mutations in gene encoding apoB-100, specifically in LDL receptor-binding domain of apoB-100.Ref (Harrison 19/e p2438-2447, 18/e p3148)
Biochemistry
null
09ce3345-10ca-4ade-91b7-8b1361c55c99
Morphine should not be used in the treatment of:
Ischemic pain
Biliary colic
Cancer pain
Post operative pain
1b
single
Morphine (an opioid) is a strong analgesic. It is used in treatment of all types of pain like Crush injury, Fracture, MI, cancer pain, post-operative pain etc. However in Biliary colic (e.g. due to any stone blocking bile duct), morphine constricts sphincter of Oddi and increase the intrabiliary pressure. This increases the chances of rupture of bile duct. Therefore opioids like morphine are contra-indicated in biliary colic.
Pharmacology
AIIMS 2018
0ef0297d-91cb-4320-9d3e-6d04ae3e9c07
Which of the following is not required for protein synthesis of eukaryotes:
RNA polymerase
Ribosomes
Peptidyl transferase
Amino acyl tRNA synthetase
0a
single
Ans. a. RNA polymerase (Ref Harper 28/e p362) RNA polymerase enzyme is involved in transcription process, not in translation.The a-amino group of the new aminoacyl-tRNA in the A site carries out a nucleophilic attach on the esterified carboxyl group of the peptidyl-tRNA occupying the P site (peptidyl or polypeptide site).Peptidyl transferase: Catalyses two reactions, peptide bond formation between amino acids and together with release factor, peptide release.
Biochemistry
null
876a5607-e467-4745-b315-13812c405904
A 16 years old girl came for evaluation of primary amenorrhea. She was having hirsutism, irregular bleeding and infeility, diagnosed as PCOS. Which of the following drugs should not be given?
Spironolactone
Tamoxifen
OCPs
Clomiphene citrate
1b
single
Answer- B. TamoxifenMedical Treatment of PCOSEstrogen best given with progesterone (combined OCPs) with no androgenic propeiesHirsutism is treated with cyproterone acetate or spironolactone.Infeility is treated with Clomiphene, 80% ovulate and 40% conceive.In Clomiphene failed group, ovulation can be induced with FSH or GnRH analogues.Metformin treats the root cause of PCOS, rectifies endocrine and metabolic functions and improves feility and isdrug of choice.
Gynaecology & Obstetrics
null
2719953f-15c7-4003-83ed-0baf2654d35a
A pregnant lady had no complaints but mild cervical lymphadenopathy in first trimester. She was prescribed spiramycin but she was noncompliant. Baby was born with hydrocephalus and intracerebral calcification. Which of these is likely cause ?
Rubella
Toxoplasmosis
CMV
Herpes
1b
single
Hydrocephalus and intracerebral calcification can occur in all the four options either commonly (Toxoplasma, CIVIV) or uncommonly (HSV, rubella). See previous explanation. However, spiramycin in pregnancy is given for toxoplasmosis. Acute maternal toxoplasmosis is usually asymptomatic, some patients may present with posterior cervical lymphadenopathy, fatigue, lassitude and maculopapular rash. Spiramycin reduces the risk of congenital infection in acute toxoplasmosis during pregnancy. As the patient was not compliant with spiramycin, baby developed congenital toxoplasmosis.
Pediatrics
null
53060ead-48de-44e0-8b8d-047e1071b424
Which of the following is not a small round cell tumor?
Neuroblastoma
Retinoblastoma
Ewing's sarcoma
Hemangiosarcoma
3d
multi
Ans. is 'd' i.e., hemangiosarcomaSmall round blue cell tumors:* Histologically many of the malignant paediatric neoplasms are unique.* They tend to have a more primitive (embryonal) rather than pleomorphic anaplastic microscopic appearance.* Often characterized by sheets of cells with small round nuclei.* Frequently exhibit features of organogenesis specific to the site of tumour origin (therefore these tumours are frequently designated by suffix - blastoma).* Owing to their primitive histological appearance many childhood tumours have been collectively referred to as small round blue cell tumourThe differential diagnosis of small round blue cell tumours includesNeuroblastomaRhabdomyosarcomaRetinoblastomaWilms tumoursEwings sarcomaMedulloblastomaLymphomaPrimitive neuroectodermal tumoursBurkitt lymphoma
Pathology
null
a36b6f9e-f19b-48b1-9d33-4845fffe975f
Which of the following is not a vitamin K dependent procoagulant?
Factor II
Factor VII
Factor IX
Factor XI
3d
single
null
Physiology
null
82b0de7a-8e54-4c49-a872-9170f2d7b599
Which of the following defines the pressure in the vascular system in the absence of blood flow?
Pulse pressure
Critical closing pressure
Mean circulatory filling pressure
Perfusion pressure
2c
single
Answer- C. Mean circulatory filling pressureMean Circulatory Filling pressure (MCFP) is equilibrium pressure that is reached throughout the cardiovascular system when cardiac output is stopped completely. MCFP can be measured by stopping blood flow (e.g., by stopping hea pumping by giving shock to hea with electricity) and allowing the pressure throughout the circulatory system to reach equilibrium. MCFP is equilibrium pressure everywhere in circulation.
Physiology
null
52d643b9-6455-43f0-a04e-a838bf1ba1c8
Pure left sided failure may be seen with –a) ASDb) Aortic stenosisc) Patent ductus arteriosusd) Pulmonary valvular obstruction
a
c
bc
ad
2c
single
ASD usually does not cause HF. AS & PDA increase the strain on left ventricle -> LVF. PS increases the strain on right ventricular failure ---> RVF.
Pediatrics
null
60522ee9-d25d-4890-a184-59a47df07377
Not included in the human poverty index is:
% of population not surviving up to 40 yrs age
Occupation
Underweight for age
% population not using safe water supply
1b
single
null
Social & Preventive Medicine
null
93899801-2aa6-4bd0-b20f-ca5835a0721f
In a patient of oral & maxillofacial trauma, cervical injury is not ruled out, intubation of preference will be:
LMA
Combitube
Normal laryngoscopy & endotracheal intubation
Fiberoptic intubation
3d
single
null
Surgery
null
4d936cfe-6c83-463a-944c-0069a8f5f11c
Fine needle aspiration cytology (FNAC) is not enough to diagnose:
Papillary carcinoma of thyroid
Follicular carcinoma of thyroid
Carcinoma breast
Adenocarcinoma lung
1b
single
Ans: B. Follicular carcinoma of the thyroid(Ref: Robbin's 9/e p1094, 8/e p1123).FNAC:Not enough to diagnose follicular carcinoma.Since follicular carcinoma is differentiated from follicular adenoma based on capsular invasion & vascular invasion (not diagnosed by FNAC).Limitations of FNAC in Thyroid Diseases:Not able to distinguish follicular adenoma from follicular carcinoma.Not able to distinguish Huhle cell adenoma from Huhle cell carcinomaUseless in Reidel's thyroiditis (Biopsy is preferred).FNAC is less reliable in patients who have a history of head & neck irradiation or family history of thyroid cancer due to the higher likelihood of multifocal lesions & occult cancer.
Surgery
null
35a8a5f6-b1f9-43ce-9d49-6dfd21e6951e
Animal test to check the biocompatibility of dental material are all except
Buehler test
Implantation test
Ame's test
Sensitization test
2c
multi
null
Dental
null
7801e0bc-129a-47f5-a8f2-5c78981b28d8
A 16-year-old girl comes to a doctor with fractured forearm. She told she tripped and fell but cigarette burns were observed on her forearm. What will be your Next step?
To inform higher authorities
To do a complete physical examination
To tell or discuss with colleagues that she is a case of abuse
To call local social worker for help
1b
multi
Ans: B. To do a complete physical examinationThe first step after suspecting s case of abuse is to do a complete detailed history taking & physical examination of the patient to see any other injuries which can confirm the findings.Concluding just by seeing a burn that looks like a cigarette burn on the forearm can be misleading at times so a thorough examination of the whole body is mandatory to confirm the above finding to child abuse.after confirmation According to the POSCO Act, every crime of child sexual abuse should be repoed. If a person who has information about any abuse fails to repo, they may face imprisonment up to six months or maybe fined or both
Forensic Medicine
null
25dc40da-7399-4011-b617-3b9c42d88277
Which of the following Is not an etiological agent for gingival recession
Gingival abrasion
Gingival ablation
Gingival inflammation
TFO
3d
single
null
Dental
null
69b97752-ee1c-4234-b3d1-0402e1235986
All of the following can be used to decrease IOP in glaucoma except
Mannitol
Carbonic anhydrase inhibitor
Apraclonidine
Dexamethasone
3d
multi
Answer: D. DexamethasoneSteroids cannot be given in glaucoma as they can themselves lead to increase in intraocular pressure
Ophthalmology
null
acf13a25-349e-4480-bc59-50c9f8e752fd
A patient taking which of the following drug should not eat cheese, etc:
Tetracycline
Amoxycillin
Doxycycline
Triamterene
0a
single
null
Pharmacology
null
cf86437d-6450-4196-9f54-8f69c84e89ba
Stress breakers are not used in partial denture construction because:
They are expensive
Increase the vertical dimension
They are difficult to design and fabricate
Harmful effect on the abutment
2c
single
null
Dental
null
29915e72-87a0-4dad-a365-6e3337e36ebe
Which is not a feature of HELLP syndrome:
Thrombocytopenia
Eosinophilia
Raised liver enzyme
Hemolytic anemia
1b
single
null
Gynaecology & Obstetrics
null
d6a8de08-5a4c-404b-8622-217e17e5751b
Which of the following complications of stroke need not to be treated?
Fever
Spasticity
Dysphagia
Numbness
1b
single
Answer- B. SpasticitySpasticity is seen in 20% of hemiplegic paitents. Spasticity per se does not produce weakness and other aspects of motor control Overzealous treatment affects the normal ambulation of patients. Hence, treating spasticity, as a rule is not always preferred, treating it is a double-edged sword. Spasticity as a consequence of a stroke may have a ceain beneficiary compensatory aspect.
Medicine
null
ab1d4d40-0a0f-405d-ac41-100856f75318
Type III gold alloy does not have following features except:
Harder than type IV
Used for small inlays
Easily burnishable than type IV
Less gold than type IV
2c
multi
null
Dental
null
e3c9cee9-73c5-4a89-8633-7ddcdc6adde9
Which of the following is not a provisional entity as per WHO 2016 classification of Acute leukemia?
AML with hyperploidy
B - ALL with BCR - ABL like mutatio
AML with BCR - ABL
Early T - cell precursor leukemia / Lymphoma
0a
multi
In Myeloid/lymphoid neoplasms with eosinophilia nad rearrangement of PDGFRA, PDGFRB, OR FGFR1, or with PCM1-JAK2 Provisional entity: Myeloid/ lymphoid neoplasms with PCM1-JAK2 In MDS Provisional entity: Refractory cytopenia of childhood In AML and related neoplasms Provisional entity: AML with BCR-ABL1 Provisional entity: AML with mutated RUNX1 In B cell lymphoblastic leukemia Provision entity: B-lymphoblastic leukemia/ lymphoma, BCR-ABL1-like Provision entity: B-lymphoblastic leukemia/ lymphoma with iAMP21 In T cell lymphoblastic leukemia Provisional entity: Early T-cell precursor lymphoblatic leukemia Provisional entity: Natural killer (NK) cell lymphoblastic leukemia/ lymphoma
Pathology
AIIMS 2018
8abcdea2-c351-4df7-ab42-8898201f9949
For which of the following, you will not perform pulpectomy?
Primary teeth with sinus tract
Primary teeth without successor
Primary teeth with furcation pathology
Pulpless primary teeth next to the line of a palatal cleft
2c
single
Primary teeth with furcation pathology, pulpectomy is not indicated, rather it requires extraction.
Dental
null
db876ffe-c2d5-4d12-9aa1-6745cac9cb2d
Video based question - AIIMS NICU - neonate shown on O2 with nasal prongs, not intubated, sister shown inseing a tube through the mouth, camera zooms in, 18 (calibration) mark seen, the other (green) end as of now not connected to anything, video ends, what is the procedure that is being done?VIDEO LINK:
Oral suction
Oropharyngeal suction
Nasogastric tube inse
Orogastric tube inseion
3d
single
Ans. D. Orogastric tube inseion
Pediatrics
null
ba0534c9-3275-481d-8130-62a393d57b2a
Cranioveebral joint does not include:
Occipital condyle
Axis
Atlas
Wings of sphenoid
3d
single
Ans: D. Wings of sphenoid(Ref Gray's 40/e p733)Cranioveebral Joint:Consists of occipital condyles, atlas & axis.Aiculation between cranium & veebral column specialized - To provide a wider range of movement.Functions as a universal joint.Permits horizontal & veical scanning movements of head.Adapted for eye-head co-ordination.
Anatomy
null
1d7c2dff-73e6-46d8-8d10-ab6ee7464701
A 10–year old male child was presented to the pediatrician for evaluation of a seizure disorder. On examination a vascular plaque was found along the ophthalmic and maxillary divisions of the trigeminal nerve. The mother informed the pediatrician that the lesion was present since birth and there was no change in morphology. The most likely possibility is –
Sturge Weber syndrome
Infantile hemangioma
Congenital hemangioma
Proteus syndrome
0a
single
This child has : Seizure disorder Vascular plaque along the ophthalmic and maxillary divisions of trigeminal nerve Lesion presenting since birth and not chonging in morphology The diagnosis is sturge weber syndrome. Sturge weber syndrome is a rare congenital vascular disorder characterized by facial capillary malformation (port wine stain) and associated capillary venous malformation affecting the brain and eye. It consists of angiomas involving the leptomeninges and skin of face typically in the ophthalmic and maxillary distributions of trigeminal nerve.
Pediatrics
null
2e82399f-9cef-4ba7-ae0e-9424c0efc321
Which of the following is not a tumor suppressor gene?
pRb
p16
PTCH
c-erbB1
3d
single
null
Pathology
null
bed477a6-5416-4f65-9859-e454fa02adbc
All of the following can cause epidemic in post-disaster period except
Leishmaniasis
Leptospirosis
Rickettsiosis
Acute respiratory infections
0a
multi
Ans. a. LeishmaniasisPost-disaster PeriodAn outbreak of gastroenteritis is the most commonly repoed disease in the post-disaster period. Increased incidence of acute respiratory infections is also common in the displaced population.Vector-borne diseases will not appear immediately but may take several weeks to reach epidemic levels. Displacement of domestic and wild animals increases the risk of transmission of zoonoses. Some of these animals may be reservoirs of infections such as leptospirosis, rickettsiosis, etc.Rickettsial diseases are also seen post-disaster especially in refugee camps.Wild animals are reservoirs of infections, which can be fatal such as equine encephalitis, rabies, and infections still unknown to humans.
Social & Preventive Medicine
null
063acadd-aa14-4684-87cb-ee4ee644da8c
A 10 years old boy came to emergency with complains of severe pain in right scrotum that is not relieved for the past 1 hour. On examination, testicular torsion of the right side is suspected. The surgical intervention should be:
Immediate scrotal exploration of the affected side and operate opposite side if symptomatic
Delay exploration and operate opposite side if symptomatic
Immediate exploration of the affected side and operate opposite side even if asymptomatic
Delayed exploration on the affected side along with the opposite side even if asymptomatic
2c
single
Testicular torsion - It is a surgical emergency - Confirm the diagnosis by decreased vascularity in Doppler (IOC) - Emergency orchidopexy- Within 4 hours - In patients of ischemia - Orchidectomy - During orchidopexy- Contralateral hemiscrotum should be explored and fixed because bell clappers deformity is usually bilateral. - Bilateral orchidopexy is preferred for Testicular torsion
Surgery
AIIMS 2019
b444b8b8-faf7-4a56-be73-c880ad2f2c8f
In which of the following condition, mandibular stabilization is not governed by the facial nerve contraction?
Infantile swallow
Mature swallow
Complex tongue thrusting
Retained infantile swallow
1b
multi
null
Dental
null
362bf8a9-de7e-48dd-aecf-3ecd13b280b8
If during an application of an orthodontic force, the level declines to zero between activations then the force duration is classified as:
Continuous force
Interrupted force
Intermittent force
Differential force
1b
single
null
Dental
null
c31b85f2-e3c3-4122-a330-2d5452dfb836
Counter bevel in tooth should not be given in
Facial surface of premolar
Occlusal surface of premolar
Lingual surface of premolar
Any surface of premolar
0a
single
Direct lines: “A counter bevel is not placed on the facial cusps of maxillary premolars and first molars due to esthetic considerations”.
Dental
null
599296cf-99e1-4a99-8322-cc24fef094a7
A Rh-negative mother, who has Indirect Coombs Test (ICT), negative was given Anti-D during 28 weeks of pregnancy. Which of the following is the ideal one?
Give another dose of Anti-D 72 hours postpaum depending on the baby blood group
Give another dose of Anti-D 72 hours postpaum irrespective of baby blood group
No need of additional dose since she is ICT negative
All of the above
0a
multi
Answer- A. Give another dose of Anti-D 72 hours postpaum depending on the baby blood groupACOG (2010) recommends anti-D immune globulin to be given prophylactically to all Rh D-negative, unsensitized women at approximately 28 weeks, and a second dose given after delivery if the infant is Rh D-positive. Before the 28-week dose of anti-D immune globulin, repeat antibocly screening is recommended to identify individuals who have become alloimmunized. Following delivery, anti-D immune globulin should be given within 72 hours.
Gynaecology & Obstetrics
null
cd0df6a2-1e8f-41e9-8304-1b8742ea993d
Anti-epileptic which is not associated with congenital malformation when used in pregnant woman is:
Phenytoin
Phenobarbitone
Carbamazepine
Valproate
1b
single
Phenobarbitone is considered as safest antiepileptic drug in pregnancy.
Medicine
null
77751054-8726-4033-9baa-2e935dba4032
Which of the following is not responsible for endogenous staining of teeth during development?
Tetracycline
Rh incompatibility
Neonatal liver disease
Vitamin-C deficiency
3d
single
null
Dental
null
937dd47d-2d03-4bb7-a36d-d82a58f565d5
A young girl hospitalised with anorexia nervosa is on treatment, Even after taking adequate food according to the recommended diet plan for last 1 week, there is no gain in weight, what is the next step in management:
Increase fluid intake
Observe patient for 2 hours after meal
Increase the do se of anxiolytics
Increase the caloric intake from 1500 kcal to 2000 kcal per day
1b
multi
Ans. B. Observe patient for 2 hours after mealIn this condition because the food is often regurgitated after meals, the staff may be able to control vomiting by making the bathroom inaccessible for at least 2 hours after meals or by having an attendant in the bathroom to prevent the oppounity for vomiting.The hospital staff should give the patients about 500 calories over the amount required to maintain their present weight (usually 1500 to 2000 calories a day).
Psychiatry
null
3728d7be-8279-4b79-a826-e568441ff21a
Which of these amino acids does not enter the Krebs cycle by forming Acetyl-CoA pyruvate?
Glycine
Tyrosine
Hydroxyprolinc
Alanine
1b
single
Ans: B. Tyrosine(Ref: Harper 30Ie p165)Tyrosine enters Krebs cycle fumarate, while all others form pyruvate to enter the Krebs cycle.
Biochemistry
null
31913a50-8459-47c0-b142-7a31df3f16c3
find false statement regarding sensory endings
Annulospiral wrap the ends
Primary ending is annulospiral
Primary ending conduct 1a fibres
Flower spray is secondary
0a
multi
null
Physiology
null
335e8fc5-5039-4876-a07e-42364a9c8cfb
Glycogen synthesis and breakdown takes place in the same cell, having enzymes necessary for both the pathways. Why the glucose-6-phosphate, freshly synthesized during glycogenesis in cytoplasm of hepatocytes, is not immediately degraded by the enzyme glucose!6-phosphatase?
The thermodynamics does not or such a reaction to occur
Glucose-6-phosphatase is present in the endoplasmic reticulum and cannot act on glycogen formed in the cytoplasm
Glycogenesis and glycogenolysis are tightly regulated such that enzymes of only one of those is present at a time.
Steric hindrance due to albumin
1b
multi
Ans: B. Glucose-6-phosphatase is present in the endoplasmic reticulum and cannot act on glycogen formed in the cytoplasm(Ref Harper 30/e p178)Glucose-6-phosphate:Formed in cytoplasm of hepatocytes.Glucose-6-phosphatase:Present in lumen of smooth endoplasmic reticulum of cell.Reaction does not take place until gluconeogenesis is ored.Glucose-6-phosphatase catalyzes hydrolysis of glucose-6-phosphate in liver - Expos glucose a increases blood glucose concentration
Biochemistry
null
25027d40-3f29-40e0-a29b-23bd913f2152
Which of the following is not a branch of external carotid artery
Posterior auricular artery
Occipital artery
Maxillary artery
Ophthalmic artery
3d
single
Branches of ECA:- Anterior - superior thyroid, lingual a., Facial a. Posterior - Occipital a., Posterior auricular a. Medial - Ascending pharyngeal a. Terminal - Maxillary a., Superficial temporal a.
Anatomy
null
4d1e7661-fffc-42d0-8bed-1e4ecc040fe8
A 35 years old female patient present with hearing loss with improvement in hearing in noisy environment. On examination Rinne's is negative and weber's is centralized. Following is the audiometry repo. What is the most likely diagnosis:
Meniere's disease
Perilymph fistula
Stapedial Otosclerosis
Vestibular Schwannoma
2c
single
POINTS OURING STAPEDIAL OTOSCLEROSIS: - Conductive hearing loss. - MC seen in females 20-30 yrs. - hears better in noisy surrounding (Paraacusis willisii) - Audiometry repo a dip at 2000Hz (Carha's notch) Meniere's disease causes SNHL. Perilymph fistula will cause SNHL. Vestibular schwannoma also will cause SNHL.
ENT
AIIMS 2019
643c04b4-2478-4bb6-972d-196073f07322
Myocardial infarction; signs are all except
‘a’ wave elevation
Levine’s sign
Kussmaul’s sign
Bradycardia in case of infarction of anterior portion of heart
3d
multi
Kussmaul sign is a paradoxical rise in jugular venous pressure (JVP) on inspiration, or a failure in the appropriate fall of the JVP with inspiration Levine's sign is a clenched fist held over the chest to describe ischemic chest pain Bradycardia, in case of ischaemia of inferior part of the heart. Tachycardia, in case of ischaemia of anterior portion of heart.
Medicine
null
ac1196e0-224c-4c6c-a6b8-2853a776ade6
Which one of the following is NOT a socio-economic indicator?
Literacy rate
Life expectancy at birth
Housing
Family size
1b
single
Socio-economic indicators: Housing Family size Literacy rate Availability per capitacalorie Per capita GNP Growth rate Level of unEmployment Dependency ratio
Social & Preventive Medicine
null
d4c4bf0d-08ef-47e6-b8e2-e530082fa63a
Which of the following drug should not be given in a patient of narrow angle glaucoma?
Phenylephrine
Timolol
Acetazolamide
Homatropine
3d
single
Answer- D. HomatropineHomatropine is a mydriatic, which can precipitate angle closure glaucoma and contraindicated in angle closure glaucoma.Phenylephrine, Timolol and Acetazolamide are used for the treatment of angle closure glaucoma.'Mydriatic drugs such as atropine, Homatropine, cyclopentolate, tropicamide and phenylephrine are precipitating factorsfor angle closure glaucoma, so contraindicated in angle closure glaucoma.
Ophthalmology
null
c848ac2e-6165-47e9-82ac-a59fb2ac705b
A patient complains of numbness of lower lip. There is no history of tooth extraction . It could be:
Infection
Metastatic neoplasia.
Dental menipulation.
CNS disease.
1b
single
null
Pathology
null
8ebdd274-45aa-4055-bc13-746368d44148
False regarding protective co-contraction muscle splinting:
Reduced mouth opening due to infection
Protective co-contraction is not a pathologic condition
There is no pain reported when the muscle is at rest, but use of the muscle will typically result in increased pain.
Altered sensory input or pain, antagonistic muscle groups fire during movement in an attempt to protect the injured part.
0a
multi
Protective Co-contraction (Muscle Splinting) Protective co-contraction is the initial response of a muscle to altered sensory or proprioceptive input or injury (or threat of injury). This response has also been called protective muscle splinting or coactivation. It is not associated with reduced mouth opening due to infection.
Dental
null
0fd8b1cf-309f-4bcd-b1d6-d6a1f07d440f
11 yr female in the school brought to principle by teacher that she is always crying unattentive not taking interest in any activity. On fuher investigation the girl told that she was inappropriately touched by her uncle at private pas at her home. Principle inform to whom ?
Child welfare
Parents
Police
Magistrate
2c
single
THE PROTECTION OF CHILDREN FROM SEXUAL OFFENCES (POCSO) ACT, 2012 * Repoing the offence to the police is mandatory. Failure to repo, attracts punishment with imprisonment of up to 6 months or fine or both. Section 19 of the POCSO Act, 2012 provides mandatory repo of child sexual offences to the Special Juvenile Police Unit or the local police
Forensic Medicine
AIIMS 2019
7ac6c505-a563-4d72-a4c7-8c9681df35b0
Wound that does not involve dermis is
Abrasion
contusion
Laceration
Incision
0a
single
null
Surgery
null
2c4a6f65-70ac-45ad-9bd5-54de396908fd
Which is not a dimorphic fungi?
P. marneffi
Histoplasma capsulatum
Blastomyces dermatitidis
Pneumocystis jirovecii
3d
single
Dimorphic fungi :- They exist as molds in the environment at ambient temperature(250C) and as yeasts in human tissues at body temperature(370C). several medically impoant fungi are thermally dimorphic such as:- Histoplasma capsulatum Blastomyces dermatitidis Coccidiodes immitis Paracoccidiodes brasiliensis Penicillium marneffei Sporothrix schenckii All of the above mentioned dimorphic fungi causes systemic mycoses except sporothrix which is responsible for sub cutaneous infection.
Microbiology
AIIMS 2017
682e030c-c972-45cf-b2d7-3146876acff7
All of the following statements about idiopathic thrombocytopenic purpura are true EXCEPT
It is associated with platelet-specific auto-antibodies
It causes a prolonged bleeding time
It is often controllable by immunosuppressive treatment
It causes more prolonged hemorrhage than hemophilia
3d
multi
null
Pathology
null
cc64f500-28ff-4757-9bef-65e53ea5685f
In a patient of rheumatic heart disease with fever and mitral valve vegetations due to infective endocarditis, the vegetation usually do no embolise to:
Brain
Lungs
Liver
Spleen.
1b
multi
null
Medicine
null
6788f1c9-7377-4903-a8df-21c81f252f7c
A lady delivered a normal vaginal delivery and was discharged. On third day she came back with fever, tachycardia and seizures. Fundus showed papilledema with no focal deficits. What is the most likely diagnosis?
Coical vein thrombosis
Meningitis
Subarachnoid hemorrhage
Acute migraine
0a
single
Answer- A. Coical vein thrombosisCoical Vein Thrombosis (CVT)Incidence of CVT is increased during pregnancy & in puerperiumIncidence appears higher in developing countries.Predisposing Factors:Prothrombotic conditions, OCPs, pregnancy, puerperiumMalignancy, infection & head injuryClinical Features:MC presenting symptom: Headaches (of gradual, acute, or thunderclap onset)Associated features may include focal neurological sings, seizures and coma.Diagnosis:Diagnosis is done with MR venography.Treatment:Anticonvulsants for seizures; heparinization is recommended by most, its efflcacy is controversial.Antimicrobials for septic thrombophlebitisFibrinolytic therapy is reserved for those women failing systemic anticoagulation
Gynaecology & Obstetrics
null
cac444fd-aa7a-4b1d-9940-826b0a6af137
Not responsible for chronic gingival inflammation?
Neutrophil
Macrophages
T-lymphocytes
Plasma cells
0a
single
null
Dental
null
8eb6ddd8-9df1-4280-b1bc-e9b8a289db82
For calculation of sample size for a prevalence study all of the following are necessary except
Prevalence of disease in population
Power of the study
Significance level
Desired precision
3d
multi
Sample size depends upon: The effect size (usually the difference between 2 groups). The population standard deviation (for continuous data). The desired power of the experiment to detect the postulated effect (Power = 1 – b) The significance level.
Dental
null
1146bb08-e590-4323-a743-83bc2d531045
A 10 year old child came to the OPD with pain and mass in right lumbar region with no fever, with right hip flexed. The pain increased on extension and X ray showed spine changes. Most probable diagnosis is:
Psoas abscess
Pyonephrosis
Appendicular lump in retrocecal position
Torsion of Right undescended testis
0a
single
From the given history: No fever Mass in right lumbar region Spine changes - Pyonephrosis, Appendicular lump in retrocecal position, Torsion of Right undescended testis can be ruled out as these conditions wont present with these clinical features Psoas abscess: Psoas Abscesses: The psoas muscle is another location in which abscesses are encountered. Psoas abscesses may arise from a hematogenous source, by contiguous spread from an intra- abdominal or pelvic process, or by contiguous spread from nearby bony structures (e.g., veebral bodies). Associated osteomyelitis due to spread from bone to muscle or from muscle to bone is common in psoas abscesses. When pott's disease was common, Mycobacterium tuberculosis was a frequent cause of psoas abscess. Currently, either S. aureus or a mixture of enteric organisms including aerobic and anaerobic gram-negative bacilli is usually isolated from psoas abscesses in the United States. S. aureus is most likely to be isolated when a psoas abscess arises from hematogenous spread or a contiguous focus of osteomyelitis; a mixed enteric flora is the most likely etiology when the abscess has an intra- abdominal or pelvic source. Patients with psoas abscesses frequently present with fever, lower abdominal or back pain, or pain referred to the hip or knee. CT is the most useful diagnostic technique."- Harrison 19/e p852 "Spinal TB (Pott's disease or tuberculous spondylitis) often involves two or more adjacent veebral bodies. Whereas the upper thoracic spine is the most common site of spinal TB in children, the lower thoracic and upper lumbar veebrae are usually affected in adults. From the anterior superior or inferior angle of the veebral body, the lesion slowly reaches the adjacent body, later affecting the interveebral disk. With advanced disease, collapse of veebral bodies results in kyphosis (gibbus). A paraveebral "cold" abscess may also form. In the upper spine, this abscess may track to and penetrate the chest wall, presenting as a soft tissue mass; in the lower spine, it may reach the inguinal ligaments or present as a psoas abscess. "Harrison 19/e p1110
Surgery
AIIMS 2017
c8c58b43-3a44-4e38-a6b3-245af1dcf2ab
The process by which the amount of a drug in the body decreases after administration, but before entering the systemic circulation is called:
Excretion
First pass effect
First order elimination
Metabolism
1b
multi
Reduction in the amount of drug before it enters the systemic circulation is called first pass metabolism (also known as first pass effect) whereas, if the amount of drug decreases after entry into the systemic circulation, it is called elimination. Latter includes excretion and metabolism.
Pharmacology
null
97b2703f-bd3b-4791-a000-bc310975d650
The following condition do not create gingival defects necessitating gingivoplasty except
Acute necrotizing ulcerative gingivitis
Desquamative gingivitis
Erosive lichen planus
Acute herpetic gingivostomatitis
0a
multi
null
Dental
null
8692345e-a600-4355-a964-bb514b16d977
Gene not involved in SCID
BTK
ZAP70
IL2RG
JAK3
0a
single
BTK gene is involved in Buon's disease or X linked agammaglobulinemia. Most cases of X linked Severe combined immunodeficiency (SCID) are due to mutations in IL2RG gene. Other mutations are defective enzyme production in Adenosine deaminase and mutations in ZAP -70 which causes defective T cell signalling which causes combined immunodeficiency and mutation occurs in JAK-3.
Microbiology
AIIMS 2019
ea6f0358-ea68-42bc-b72c-d1fcaad7e10e
Lip and mentalis muscle contraction are not seen in:
Mature swallow
Simple tongue thrust
Complex tongue thrust
All of the above
0a
multi
null
Dental
null
519a4ff4-7e05-455a-b8dd-edd85636dccf
Which of the following is not true regarding teeth features and ethnicity?
Upper third molar is most commonly absent in Mongolians
Carabelli cusps are seen in Caucasians
Negros have wide molar cusps and deep, shovel shaped cusps in incisors
Prominent lingual ridge and labial ridge is seen in Mongolians
2c
multi
Answer- C. Negros have wide molar cusps and deep, shovel-shaped cusps in incisors The presence of shovel-shaped incision is a feature of Mongolians, and it is uncommon in Negros.A congenital lack of the third upper molar is most common in Mongolians but can occur in any race. Small nodules on the lingual surface of maxillary molars, called 'Carabelli's cusp', are most common in Caucasian races and rare in the other major racial groups. Negroid races tend to have large teeth and often have more cusps on their molars, even up to eight, with two lingual cusps on the mandibular first premolars as an additional common finding.
Forensic Medicine
null
d8e3d7c2-cf2f-4dad-a3ad-50352f228de4
Not true about NRHM
Appoint ASHA
Strengthen institutional delivery under JSY
Health and family welfare societies
State and district health mission
2c
multi
null
Dental
null
dc020962-d8a1-4790-b268-c6dadb000137
A term neonate with unconjugated hyperbilirubinemia of 18 mg/dl on 20th day. All are common causes except –
Breast rnilk jaundice
Congenital cholangiopathy
G 6PD deficiency
Hypothyroidism
1b
multi
This child has unconjugated hyperbilirubinemia, while congenital cholangiopathy causes conjugated hyperbilirubinemia. reastfeeding jaundice and Breastmilk jaundice There is strong association between exclusive breastfeeding and neonatal jaundice. A few babies who remain on exclusive breast feed develop jaundice in the second week of life and continue well into the third month. This is called breastmilk jaundice. A bilirubin level of over 20 mg/dl may be attained. (It is presumed to be due to inhibitory substances in the breastmilk that interfere with bilirubin conjugation e.g. pregananediol and free fatty acids). Temporary interruption of breastmilk feeds will dramatically reduce the serum levels of bilirubin and there may be slight increase in bilirubin when breast feeding is resumed, but it never reaches the previous levels. Hypothyroidism   Persistent elevation of indirect bilirubin is the first sign of congenital hypothyroidism in neonates. This is due to decreased activity of UDPGT for weeks or months after birth. At least 10% of all infants with congenital hypothyroidism will have jaundice as the presenting symptom. Treatment with thyroxine promptly alleviates jaundice. G-6PD deficiency There is hemolytic anemia that results in increased production of unconjugated bilirubin.
Pediatrics
null
38d19909-c427-44de-9fff-8b43342040ea
Calculate net filtration pressure with the following data: PGC = 42 mm Hg pGC = 12 mm Hg PBC= 16 mm Hg Assume that no proteins were filtered.
34 mm Hg
Data not sufficient
14 mm Hg
28 mm Hg
2c
single
Force oring filtration = Glomerular capillary hydrostatic pressure(PGC = 42mm Hg) Forces opposing filtration = Plasma colloid oncotic pressure (pGC = 12 mm Hg) Bowman's capsule hydrostatic pressure (PSC = 16mm Hg) : Net = PsC + pGC = 12 + 16= 28mm Hg : NET FILTRATION PRESSURE = 42 - 28 mm Hg = 14mm Hg.
Physiology
AIIMS 2018
da743fb8-1db4-4fee-9e20-351d78dc60c9
Presented edema, oliguria and frothy urine. He has no past history of similar complaints. On examination, his urine was positive for 3+ proteinuria, no RBCs/WBCs and no casts. His serum albumin was 2.5 gm/L and serum creatinine was 0.5 mg/dL. The most likely diagnosis is:
Minimal change disease
IgA nephropathy
Interstitial nephritis
Membranous nephropathy
0a
single
Ans: A.Minimal change disease(Ref Harrison 19/e p184, 18/2345)Most likely diagnosis - Minimal change disease.Minimal Change Disease:Peak age of onset = Between 6-8 years of age (usually <10 years)Type of onset = InsidiousTypical presentation = Nephrotic syndromeHallmark of Nephrotic syndrome =Peripheral edema.Occurs when serum albumin levels < 3 gm/dlLaboratory findings = Proteinuria & hypoalbuminemia.
Pediatrics
null
752fa9af-ae3d-444f-aa2a-4d6c2b0b20d2
Which of the following is not attached laterally to thyroid cartilage, or all the following muscles are attached to the oblique line of thyroid cartilage except:
Sternothyroid
Thyrohyoid
Superior constrictor
Inferior constrictor
2c
multi
Larynx is composed of nine cartilage out of which 3 are paired and 3 unpaired. Paired - Arytenoids, corniculates and cuneiforms. Unpaired - Thyroid, cricoids, epiglottis. Thyroid cartilage is the largest cartilage of larynx. On the lateral surface of thyroid cartilage three extrinsic laryngeal muscle are connects to it as: Sternohyoid Thyrohyoid Inferior pharyngeal constrictor.
Anatomy
null
1dc55cbe-41dc-4dda-9e52-cbc66d59d9b6
Antischkow cells are present in all of the following conditions except
Sickle cell anaemia
Iron deficiency anaemia
Apthous ulcer
herpes simplex
3d
multi
null
Pathology
null
5eb813a6-a84e-4b34-ae56-80e38f5a44b5
Patient on dental chair during extraction becomes unconscious; patient is breathing but not responsive. Your first step will be:
Recline chair and shout for help and give oxygen
Check BP and pulse and intubate
Start CPR immediately
ECG
0a
multi
null
Surgery
null
e356b193-bb0c-4a38-9d5b-e14317c5ec09
Which of the following structures is not present on the internal surface of mandible?
Genial tubercle
Mylohyoid ridge
Lingula
Mental foramen
3d
single
Mental foramen is present on the outer surface of body of mandible between the roots of two premolars
Anatomy
null
38b6ac73-f821-4d98-a15c-f42f59044aac
A mother and her 4 year old son are seated alone in a reception area with the child staring off into space, rocking and constantly twisting a strand of hair about his fingers. Upon entry of another person, the child begins to beat his fist against the side of his face and behaves as though he does not hear his mother speaking to him. This behavior is most characteristic of:
An autistic child
A mentally retarded child
First dental appointment anxieties of a 4 year old child
A child with a chronic seizure disorder
0a
multi
null
Dental
null
d8f1b1c9-0dee-4d4b-9ab1-d0380a4e2502
Which one of the following is not FDA approved
GEM 215
Elyzol
Periochip
Atridox
1b
single
null
Dental
null
3a540909-ac85-4d6b-a7af-be0300a93207
All are features of non paralytic polio except –
Absent deep tendon reflexes
Head drop
Nuchal rigidity
Knee heel test negative
0a
multi
Poliomyelitis The usual age group affected by poliomyelitis is between 6 months to 3 years. Incubation period —> 7-14 days. Clinical manifestations Clinical course of Poliomyelitis has following stages. 1. Inapparent (subclinical) infection Occurs in 95% of infected individuals. Patient is asymptomatic 2. Minor (abortive) illness 1114-8% of infection. Fever, sore throat, headache adn malaise. Associated with phase of viremia. Lasts for 1 to 5 days ​ 3. Aseptic meningitis In 1% of infected cases. Signs of menigitis —> Neck rigidity, vomiting etc. 4. Paralytic polio In less than 1% of infections. Note : First 3 stages are non-paralytic polio.
Pediatrics
null
36535f13-db82-4771-afd8-3f210207b234
Which of the following conversions does not require Biotin as a cofactor?
Gamma carboxylation of glutamate
Acetyl Co-A to Malonyl Co-A
Propionyl Co-A to methyl malonyl Co-A
Pyruvate to oxaloacetate
0a
single
Ans: A. Gamma carboxylation of glutamate(Ref: Harrison 19/e p96e-5; Harper 30/e p550, 561)Gamma carboxylation of glutamate:Carried out by Gamma-glutamyl carboxylase.Gamma-glutamyl carboxylase:Vitamin-K dependent enzyme.Catalyzes post-translational modification of vitamin K-dependent proteins.Biotin:Transfers carbon dioxide in reactions like acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase & methylcrotonyl-CoA carboxylase.Biotin functions to transfer carbon dioxide in reactionsPyruvate carboxylasePyruvate (3C) to oxaloacetate (4C) in gluconeogenesisdegAcetyl-CoA carboxylaseAcetyl-CoA (2C) to malonyl-CoA (3C) in lipid synthesis.Propionyl-CoA carboxylasePropionyl-Co A (3C) to methylmalonyl-CoA (4C) inMethylmalonyl CoA carboxyl Propionic acid synthesis in bacteriaMethylcrotonyl-CoA carboxylaseLeucine catabolism
Biochemistry
null
ca435de5-729e-4d62-8d92-116f5afb5a48
The concentration of a negative ion is 100 mMoUL extracellular and 10 mMo1/1 intracellular. What will be the Nernst potential for this ion?
--10 mV
+10 mV
--61 mV
+61 mV
2c
single
Ans: C. --61 mVRef: Ganong 25Ie p9, p24Ie p9-10; Guyton 13Ie p61Ek = 61.5 log Ci/CeIntracellular concentration Ci = 100Extracellular concentration Ce = 10EK = 61 C log100/10 = -61 mV.
Physiology
null
515dde1e-02e3-41d5-a88f-3d2a99421bde
The enamel has no capacity of self —repair because
It has only a small percent of organic content
Its formative cells are lost once it is completely formed
It is essentially a keratin tissue and has no blood vessels
It has no direct connection with the active cells of the dental pulp
1b
multi
null
Dental
null
4babb6af-7f56-4e4b-a5b5-df775b7928c5
All parasites are in hepatocytes Except ?
Toxoplasma
P. falciparium
Leishmania
Babesia
3d
multi
Answer- D. Babesia* Babesia is an parasite which parasitizes RBCs like Plasmodium* visceral leishmaniasis is an infection in hepatocytes ,* Malaria especially with Plasmodium falciparum hepatomegaly can develop early and subsides with treatment.
Microbiology
null
c392ae6f-bcce-4129-9357-c99cf10dbafa
Which of the following is not true regarding iron supplementation in iron deficiency anemia?
Administer a small diluted dose first prior to infusion to look for any allergy to iron preparation
Oral iron therapy should be stopped once the patient achieves a hemoglobin of >12 mg/dL
If gastric intolerance to oral iron therapy occurs, all patients should be administered parenteral forms
Parenteral iron supplementation is required in a patient with Hb of less then 7 mg/dL
1b
multi
Ans: B. Oral iron therapy should be stopped once the patient achieves a hemoglobin of >12 mg/dL(Ref: Harrison 19/e p629. 18/e p849)Iron-deficiency anemia - Goal of therapy:Not only repair anemia.Provide stores of at least 0.5-1 g of iron.Sustained treatment for period of 6-12 months after anemia correction necessary to achieve stores.
Medicine
null
33a771be-dfbc-4cdd-bb77-09b838ffea2a
Which of the following is not the diagnostic feature of Apert syndrome:
Bicoronal craniosynostosis
Midface hypoplasia
Mandibular hypoplasia
Complex syndactyly
2c
single
null
Dental
null
94f8a4d4-c1b9-4c3e-a71a-dd4658d92dd7
Which of the following is not an obstructive cause of mouth breathing:
Deviated nasal septum.
Short lip.
Narrow maxilla.
Obstructive adenoids.
1b
single
Short lip is an anatomic cause.
Dental
null
2374ffe7-dc10-4f81-9ec7-0c883fb64c55
All are true about use of articaine in a child except
It's an amide which is metabolised in both plasma and liver
Plasma half-life is 90 min
Infiltration produces adequate anaesthesia in primary molar so need for block anesthesia is eliminated
More breakdown cause less toxicity
1b
multi
null
Surgery
null
525c0f64-0789-4991-9192-e8e8b7e65f43
Good contacts in primary teeth with lack of spacing predicts?
Normal occlusion in permanent teeth
Crowding in permanent teeth
Anterior cross bite
Spaced permanent dentition
1b
single
null
Dental
null