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Digital Dialogue-How Youth Are Interacting With Chatbots

Abstract: This Viewpoint describes the use of large language model chatbots in social, educational, and therapeutic settings and the need to assess when children are developmentally ready to engage with them.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

A unificationist approach to wrongful pure risking

Abstract: What makes cases of pure risking sometimes wrong? There is a strong intuition that the wrongness of pure risking stands in an explanatory relationship with the wrongness of the non-risky act. Yet, we cannot simply take this for granted insofar as in cases of wrongful pure risking, the risked outcome fails to materialize. To this end, I motivate and develop an under explored approach in the literature that I call Unificationism. According to the Unificationist account that I defend, the fact that pure risking phi is pro tanto wrong is grounded by a general moral fact that phi-ing is pro tanto or all-things-considered wrong, other things being equal. This relationship holds even if and when an agent's risky conduct fails to transpire or culminate into phi-ing ex post. I argue that this Unificationist account captures our explanatory intuition, avoids problems of extensional and explanatory inadequacy that existing alternative faces, and most importantly, renders Unificationism as a plausible view within the ethics of pure risking.

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Potential scale of industrial outputs of the bronze bell casting industry in 500 BCE China

Abstract: The potential scale of industrial outputs in the ancient world is often underestimated in current archaeological studies due to the lack of surviving artifacts for validation of the production scale. However, production traces left on extant artifacts can help us reconstruct production methods, and thus reveal the potential scale of production outputs of certain industries, even although there may not be a sufficient number of existing artifacts to demonstrate such volumes. The bronze bell casting industry operating in around 500 BCE in Xinzheng in Henan province, China, can be used as an example to demonstrate the then use by bell casters of the pattern-block method to efficiently create multiple bells sharing identical components. With their strong focus on efficiency, production speed, and low production costs, these casters intelligently designed assembly lines and assembled identical components replicated from models to prepare molds for casting. Knowledge of their production methods and currently preserved bells can provide evidence that the bell casting industry produced industrial outputs on a massive scale that was rare in the ancient world. This article also shows how innovative methods such as 3D model superimposition can be used to validate these hypotheses.

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Path planning algorithm for percutaneous puncture lung mass biopsy procedure based on the multi-objective constraints and fuzzy optimization

Abstract: Objective. The percutaneous puncture lung mass biopsy procedure, which relies on preoperative CT (Computed Tomography) images, is considered the gold standard for determining the benign or malignant nature of lung masses. However, the traditional lung puncture procedure has several issues, including long operation times, a high probability of complications, and high exposure to CT radiation for the patient, as it relies heavily on the surgeon's clinical experience. Approach. To address these problems, a multi-constrained objective optimization model based on clinical criteria for the percutaneous puncture lung mass biopsy procedure has been proposed. Additionally, based on fuzzy optimization, a multidimensional spatial Pareto front algorithm has been developed for optimal path selection. The algorithm finds optimal paths, which are displayed on 3D images, and provides reference points for clinicians' surgical path planning. Main results. To evaluate the algorithm's performance, 25 data sets collected from the Second People's Hospital of Zigong were used for prospective and retrospective experiments. The results demonstrate that 92% of the optimal paths generated by the algorithm meet the clinicians' surgical needs. Significance. The algorithm proposed in this paper is innovative in the selection of mass target point, the integration of constraints based on clinical standards, and the utilization of multi-objective optimization algorithm. Comparison experiments have validated the better performance of the proposed algorithm. From a clinical standpoint, the algorithm proposed in this paper has a higher clinical feasibility of the proposed pathway than related studies, which reduces the dependency of the physician's expertise and clinical experience on pathway planning during the percutaneous puncture lung mass biopsy procedure.

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The politics of allyship: Multiethnic coalitions and mass attitudes toward protest.

Abstract: Recent work finds that nonviolent resistance by ethnic minorities is perceived as more violent and requiring more policing than identical resistance by ethnic majorities, reducing its impact and effectiveness. We ask whether allies-advantaged group participants in disadvantaged group movements-can mitigate these barriers. On the one hand, allies can counter negative stereotypes and defuse threat perceptions among advantaged group members, while raising expectations of success and lowering expected risks among disadvantaged group members. On the other hand, allies can entail significant costs, carrying risks of cooptation, replication of power hierarchies, and marginalization of core constituencies. To shed light on this question we draw on the case of the Black Lives Matter (BLM) movement, which, in 2020, attracted unprecedented White participation. Employing a national survey experiment, we find that sizeable White presence at racial justice protests increases protest approval, reduces perceptions of violence, and raises the likelihood of participation among White audiences, while not causing significant backlash among Black audiences. Black respondents mostly see White presence as useful for advancing the movement's goals, and predominant White presence reduces expectations that protests will be forcefully repressed. We complement these results with analysis of tens of thousands of images shared on social media during the 2020 BLM protests, finding a significant association between the presence of Whites in the images and user engagement and amplification. The findings suggest that allyship can be a powerful tool for promoting sociopolitical change amid deep structural inequality.

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Strength Training Perceptions Amongst Vocational Circus and Dance Students.

Abstract: Introduction: The aim of this study was to analyze perceptions of strength training in vocational circus and dance students. It was hypothesized that due to the higher relative strength demands and associated risks of working at height in some aerial and acrobatic disciplines that circus students would be more open to strength training than dancers. Methods: Eighty students completed the Training Information Survey (TIS) (Mean age=20.74±2.71); 39 circus students and 41 dance students. 97% of circus students and 69% of dance participants reported that strength training was a required part of their training with students participating in strength training 4.24±0.98 and 3.05±1.42day per week respectively. Results: Perceptions of strength training amongst vocational circus and dance students appear to be favorable, with both sets of students strongly agreeing with the statements Strength training is essential to my overall development as a dancer/circus artist (5.00 (IQR 1.00) and 5.00 (IQR 1.00) respectively). Following Bonferonni correction only one statement returned statistically significant results with dance students agreeing more strongly with the statement Strength training increases muscle size, U=473.00, P=.001. Students also agreed that strength training helped them to feel better mentally and physically, that strength training is beneficial for both men and women and that it should not be designated as specific to either sex. Conclusion: Results support earlier studies that suggest a cultural shift in perceptions of strength training and ideal esthetic in dance, particularly amongst students and that they are keen to incorporate strength training into their practice. Educational establishments should note students' interest in participating in strength training, reviewing how to embed effective strength training education, more coaching and time allowance for these activities within their timetable. Further research with a greater sample size is recommended to further substantiate these indications of a shift in perceptions.

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Palaeogenomic insights into the origins of early settlers on the island of Cyprus.

Abstract: Archaeological evidence supports sporadic seafaring visits to the Eastern Mediterranean island of Cyprus by Epipaleolithic hunter-gatherers over 12,000 years ago, followed by permanent settlements during the early Neolithic. The geographical origins of these early seafarers have so far remained elusive. By systematically analysing all available genomes from the late Pleistocene to early Holocene Near East (c. 14,000-7000 cal BCE), we provide a comprehensive overview of the genetic landscape of the early Neolithic Fertile Crescent and Anatolia and infer the likely origins of three recently published genomes from Kissonerga-Mylouthkia (Cypriot Late Pre-Pottery Neolithic B, c. 7600-6800 cal BCE). These appear to derive roughly 80% of their ancestry from Aceramic Neolithic Central Anatolians residing in or near the Konya plain, and the remainder from a genetically basal Levantine population. Based on genome-wide weighted ancestry covariance analysis, we infer that this admixture event took place roughly between 14,000 and 10,000 BCE, coinciding with the transition from the Cypriot late Epipaleolithic to the Pre-Pottery Neolithic A (PPNA). Additionally, we identify strong genetic affinities between the examined Cypro-LPPNB individuals and later northwestern Anatolians and the earliest European Neolithic farmers. Our results inform archaeological evidence on prehistoric demographic processes in the Eastern Mediterranean, providing important insights into early seafaring, maritime connections, and insular settlement.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

The politics of allyship: Multiethnic coalitions and mass attitudes toward protest.

Abstract: Recent work finds that nonviolent resistance by ethnic minorities is perceived as more violent and requiring more policing than identical resistance by ethnic majorities, reducing its impact and effectiveness. We ask whether allies-advantaged group participants in disadvantaged group movements-can mitigate these barriers. On the one hand, allies can counter negative stereotypes and defuse threat perceptions among advantaged group members, while raising expectations of success and lowering expected risks among disadvantaged group members. On the other hand, allies can entail significant costs, carrying risks of cooptation, replication of power hierarchies, and marginalization of core constituencies. To shed light on this question we draw on the case of the Black Lives Matter (BLM) movement, which, in 2020, attracted unprecedented White participation. Employing a national survey experiment, we find that sizeable White presence at racial justice protests increases protest approval, reduces perceptions of violence, and raises the likelihood of participation among White audiences, while not causing significant backlash among Black audiences. Black respondents mostly see White presence as useful for advancing the movement's goals, and predominant White presence reduces expectations that protests will be forcefully repressed. We complement these results with analysis of tens of thousands of images shared on social media during the 2020 BLM protests, finding a significant association between the presence of Whites in the images and user engagement and amplification. The findings suggest that allyship can be a powerful tool for promoting sociopolitical change amid deep structural inequality.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Comparative analysis of Cochrane and non-Cochrane reviews over three decades.

Abstract: BACKGROUND: Systematic reviews are viewed as the best study design to guide clinical decision-making as they are the least biased publications assuming they are well-conducted and include well-designed studies. Cochrane was initiated in 1993 with an aim of conducting high-quality systematic reviews. We aimed to examine the publication rates of non-Cochrane systematic reviews (henceforth referred to simply as systematic reviews) and Cochrane reviews produced throughout Cochrane's existence and characterize changes throughout the period.METHODS: This observational study collected data on systematic reviews published between 1993 and 2022 in PubMed. Identified Cochrane reviews were linked to data from the Cochrane Database of Systematic Reviews via their Digital Object Identifier. Systematic reviews and Cochrane reviews were analyzed separately. Two authors screened a random sample of records to validate the overall sample, providing a precision of 98%.RESULTS: We identified 231,602 (94%) systematic reviews and 15,038 (6%) Cochrane reviews. Publication of systematic reviews has continuously increased with a median yearly increase rate of 26%, while publication of Cochrane reviews has decreased since 2015. From 1993 to 2002, Cochrane reviews constituted 35% of all systematic reviews in PubMed compared with 3.5% in 2013-2022. Systematic reviews consistently had fewer authors than Cochrane reviews, but the number of authors increased over time for both. Chinese first authors conducted 15% and 4% of systematic reviews published from 2013-2022 and 2003-2012, respectively. Most Cochrane reviews had first authors from the UK (36%). The native English-speaking countries the USA, the UK, Canada, and Australia produced a large share of systematic reviews (42%) and Cochrane reviews (62%). The largest publishers of systematic reviews in the last 10years were gold open access journals.CONCLUSIONS: Publication of systematic reviews is increasing rapidly, while fewer Cochrane reviews have been published through the last decade. Native English-speaking countries produced a large proportion of both types of systematic reviews. Gold open access journals and Chinese first authors dominated the publication of systematic reviews for the past 10years. More research is warranted examining why fewer Cochrane reviews are being published. Additionally, examining these systematic reviews for research waste metrics may provide a clearer picture of their utility.

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Threaten, Distract, and Discredit: Cannabis Industry Rhetoric to Defeat Regulation of High-THC Cannabis Products in Washington State.

Abstract: OBJECTIVE: Washington State legislators have attempted to regulate high delta-9-tetrahydrocannabinol (THC) cannabis to reduce cannabis-related harms. Historically, industry actors of other health-compromising products have influenced governments' adoption of evidence-based regulation policies. A better understanding of the industry rhetoric can be used by public health advocates to develop counterarguments and disseminate alternative narratives that protect the public's health. We analyzed the arguments used by cannabis industry actors opposing regulations to de-incentivize the availability and use of high-THC products in Washington State.METHOD: We analyzed 41 testimonies transcribed from 33 cannabis industry actors in 3 public bill hearings and one legislative work session that occurred between 2020 and 2023. Using a deductive thematic analysis, informed by industry actors' arguments opposing regulation of alcohol, tobacco, and high-sugar beverages, we developed a codebook to analyze and identify themes within cannabis industry rhetorical strategies.RESULTS: We identified three main rhetorical strategies used by cannabis industry actors to oppose THC content regulation: threaten, distract, discredit. The most frequently used rhetorical strategy was threats to economic benefits, public health, and the will of the people. The other two most apparent strategies were distracting from the bill's focus by introducing a tangential topic and discrediting the science that supported regulation of cannabis products with high THC concentration or its advocates.CONCLUSIONS: Cannabis industry actors have leveraged several arguments used by industry actors of other health-compromising products to undermine initiatives to advance public health. They have also adapted rhetoric from other industries to the unique conditions of the cannabis regulatory landscape.

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Frans de Waal (1948-2024).

Abstract: Primatologist who brought animals and humans a little closer.

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Refutations and Proofs in the Paraconsistent Modal Logics: KN4 and KN4.D

Abstract: Axiomatic proof/refutation systems for the paraconsistent modal logics: KN4 and KN4.D are presented. The completeness proofs boil down to showing that every sequent is either provable or refutable. By constructing finite tree-type countermodels from refutations, the refined characterizations of these logics by classes of finite tree-type frames are established. The axiom systems also provide decision procedures for these logics.

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Rules of Explosion and Excluded Middle: Constructing a Unified Single-Succedent Gentzen-Style Framework for Classical, Paradefinite, Paraconsistent, and Paracomplete Logics

Abstract: A unified and modular falsification-aware single-succedent Gentzen-style framework is introduced for classical, paradefinite, paraconsistent, and paracomplete logics. This framework is composed of two special inference rules, referred to as the rules of explosion and excluded middle, which correspond to the principle of explosion and the law of excluded middle, respectively. Similar to the cut rule in Gentzen's LK for classical logic, these rules are admissible in cut-free LK. A falsification-aware single-succedent Gentzen-style sequent calculus fsCL for classical logic is formalized based on the proposed framework. The calculus fsCL is obtained from the existing falsification-aware single-succedent Gentzen-style sequent calculus GN4 for Nelson's paradefinite (or paraconsistent) four-valued logic N4 by adding the rules of explosion and excluded middle. A falsification-aware single-succedent Gentzen-style sequent calculus GN3 for Nelson's paracomplete three-valued logic N3 is also obtained from GN4 by adding the rule of explosion. The cut-elimination theorems for fsCL, GN3, and some of their neighbors as well as the Glivenko theorem for fsCL are proved.

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Improving clinical reasoning and communication during handover: An intervention study of the BRIEF-C tool.

Abstract: BACKGROUND: Existing handover communication tools often lack a clear theoretical foundation, have limited psychometric evidence, and overlook effective communication strategies for enhancing diagnostic reasoning. This oversight becomes critical as communication breakdowns during handovers have been implicated in poor patient care. To address these issues, we developed a structured communication tool: Background, Responsible diagnosis, Included differential diagnosis, Excluded differential diagnosis, Follow-up, and Communication (BRIEF-C). It is informed by cognitive bias theory, shows evidence of reliability and validity of its scores, and includes strategies for actively sending and receiving information in medical handovers.DESIGN: A pre-test post-test intervention study.SETTING: Inpatient internal medicine and orthopaedic surgery units at one tertiary care hospital.INTERVENTION: The BRIEF-C tool was presented to internal medicine and orthopaedic surgery faculty and residents who participated in an in-person educational session, followed by a 2-week period where they practised using it with feedback.MEASUREMENTS: Clinical handovers were audiorecorded over 1week for the pre- and again for the post-periods, then transcribed for analysis. Two faculty raters from internal medicine and orthopaedic surgery scored the transcripts of handovers using the BRIEF-C framework. The two raters were blinded to the time periods.RESULTS: A principal component analysis identified two subscales on the BRIEF-C: diagnostic clinical reasoning and communication, with high interitem consistency (Cronbach's alpha of 0.82 and 0.99, respectively). One sample t-test indicated significant improvement in diagnostic clinical reasoning (pre-test: M=0.97, SD=0.50; post-test: M=1.31, SD=0.64; t(64)=4.26, p<0.05, medium to large Cohen's d=0.63) and communication (pre-test: M=0.02, SD=0.16; post-test: M=0.48, SD=0.83); t(64)=4.52, p<0.05, large Cohen's d=0.83).CONCLUSION: This study demonstrates evidence supporting the reliability and validity of scores on the BRIEF-C as good indicators of diagnostic clinical reasoning and communication shared during handovers.

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Density functional theory for doped TiO2: current research strategies and advancements

Abstract: Since the inception of the density functional theory (DFT) by Hohenberg and Kohn in 1964, it rapidly became an indispensable theoretical tool across various disciplines, such as chemistry, biology, and materials science, among others. This theory has ushered in a new era of computational research, paving the way for substantial advancements in fundamental understanding. Today, DFT is routinely employed for a diverse range of applications, such as probing new material properties and providing a profound understanding of the mechanisms underlying physical, chemical, and biological processes. Even after decades of active utilization, the improvement of DFT principles has never been slowed down, meaning that more accurate theoretical results are continuously generated with time. This work highlights the latest achievements acquired by DFT in the specific research field, namely the theoretical investigations of doped TiO2 systems, which have not been comprehensively reviewed and summarized yet. Successful progress in this niche is currently hard to imagine without the support by DFT. It can accurately reveal new TiO2 properties after introducing the desired dopant and help to find the optimal system design for a specific application prior to proceeding to more time-consuming and expensive experimental research. Hence, by evaluating a selection of the most recent research studies, we aim to highlight the pertinent aspects of DFT as they relate to the study of doped TiO2 systems. We also aim to shed light on the strengths and weaknesses of DFT and present the primary strategies employed thus far to predict the properties of various doped TiO2 systems reliably.

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The evolution of Pemphigus publications: A bibliometric analysis with research trends and global productivity.

Abstract: Despite an increase in global research on the subject of Pemphigus, which seriously affects patient health and quality of life, there is no bibliometric research on this subject in literature to date. The aim of this study was to conduct a holistic analysis of scientific articles published on Pemphigus, using bibliometric methods. Articles published on the subject of Pemphigus between 1980 and 2021 were downloaded from the web of science (WoS) database and analyzed using various statistical methods. To determine trend subjects, collaboration between countries, and the most effective studies with citation analyses, visual network maps were obtained with bibliometric analyses. A total of 3034 articles were analyzed. The 3 countries making the greatest contribution to literature were the USA (n:831, 27.3%), Japan (n:402, 13.2%), and Germany (n:221, 7.2%). The 3 most active institutions were Keio University (n:163, 5.3%), Kurume University (n:130, 4.2%) and Tel Aviv University (n:107, 3.5%). The 3 journals publishing the most articles were the British Journal of Dermatology (n: 88), Journal of the American Academy of Dermatology (n:171) and the Journal of Investigative Dermatology (n:143). The 3 leading journals according to the mean number of citations (NC) per article (citation count: CC) were the New England Journal of Medicine (CC:246), the Lancet (CC:143) and the Journal of Cell Biology (CC:133). The author with the most articles published was Hashimoto Takashi (n.168, 5.5%). As a result of cluster analysis, it was seen that 9 different main clusters had been studied on Pemphigus subjects to date (1: desmoglein, 2: paraneoplastic Pemphigus (PNP) - Pemphigus types-desmosome, 3: desmoglein 1 ve 3-autoimmunity, 4: treatment-rituximab, 5: acantholysis-apoptosis, 6: quality of life-remission-relapse, 7: autoantibodies, 8: epidemiology-mortality, 9: corticosteroids). The most commonly studied subjects were determined to be pemphigus vulgaris (PV), pemphigus foliaceus (PF), autoimmunity, rituximab, PNP, desmoglein (desmoglein3-desmoglein1), autoantibodies, acantholysis, autoantibody, treatment, autoimmune disease, desmosome, ELISA, and immunofluorescence. The primary trending topic was rituximab drug, which is used in the treatment of Pemphigus. The other most studied trend topics were azathioprine drug used in treatment, intravenous immunoglobulin treatment, quality of life, mortality rates, Pemphigus herpetiformis, and wound healing.

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Economic Burden of Acute Gastroenteritis among Members of Integrated Healthcare Delivery System, United States, 2014-2016.

Abstract: We conducted a large surveillance study among members of an integrated healthcare delivery system in Pacific Northwest of the United States to estimate medical costs attributable to medically attended acute gastroenteritis (MAAGE) on the day care was sought and during 30-day follow-up. We used multivariable regression to compare costs of MAAGE and non-MAAGE cases matched on age, gender, and index time. Differences accounted for confounders, including race, ethnicity, and history of chronic underlying conditions. Analyses included 73,140 MAAGE episodes from adults and 18,617 from children who were Kaiser Permanente Northwest members during 2014-2016. Total costs were higher for MAAGE cases relative to non-MAAGE comparators as were costs on the day care was sought and costs during follow-up. Costs of MAAGE are substantial relative to the cost of usual-care medical services, and much of the burden accrues during short-term follow-up.

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An Adaptive Extended Kalman Filter With Passivity-Based Control for DC-DC Converter in DC Microgrids Supplying Constant Power Loads

Abstract: This article proposes an adaptive nonlinear control strategy to eliminate the instability problem of buck converters in dc microgrids (DCMG) considering constant power load (CPL). The strategy includes an Adaptive Passivity-Based Controller (PBC) and an Adaptive Extended Kalman Filter (AEKF). The proposed AEKF performs faster and more accurately than the conventional EKF and adjusts the covariance matrices adaptively. Furthermore, this AEKF directly estimates the unknown CPL power supplied by the converter and prevents the number of measurement sensors from increasing. Hence, PBC ensures system stability alongside AEKF. The controller guarantees Lyapunov stability and fast dynamic response in the presence of uncertainties and perturbations compared to other nonlinear methods. MATLAB simulations and laboratory implementation are provided to confirm the performance and robustness of the proposed control strategy and validate the analysis.

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Technical and economic history of western Han dynasty revealed by bronze mirrors from Zonglvcheng cemetery, Linzi, China

Abstract: In this study bronze mirrors from the Zonglvcheng cemetery in Linzi city, the unique bronze mirror production centre of the Western Han dynasty (WHD, 202 BCE-8 CE), were subjected to scientific examinations. Compositional and lead isotope ratio analyses on 41 bronze mirrors from different periods of WHD were conducted. For the first time, a mirror made of pure lead and another one made with highly radiogenic lead were identified. The compositional analysis revealed a roughly stable copper-tin-lead ratio of 14:5:1 for mirrors, providing insights into the standardised mirror production. The interpretation of isotope ratios was done by combining characteristic parameters and kernel density estimate methods, compiling a wide range of published data for comparison to mitigate the detrimental effects of the overlap effect. The results indicate that the majority of mirrors were produced within Linzi city, but their lead sources were likely from the Xiaoqinling metallogenic belt controlled by the Han Empire rather than local to Shandong province. This study demonstrates that changes in the alloy compositions and ore sources for bronze mirrors and other objects with time were influenced by state-intervention economic policies, providing a new perspective for the study of technical and economic history during the WHD.

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New horizon in improving ageing with improvisational theatre.

Abstract: Cognitive decline, mental health and mindset factors can all affect the autonomy and well-being of older adults. As the number of older adults across the globe increases, interventions to improve well-being are urgently needed. Improvisational theatre (improv) and improv-based interventions are well-suited to address this need. Studies have shown that participation in improv-based interventions has a positive impact on mental health indicators, including depressive symptoms, well-being and social connectedness, as well as cognitive skills such as attention and memory. In addition, improv-based interventions have been beneficial for people with dementia, improving positive affect, self-esteem and communication. In this article, we describe improvisational theatre, or improv, and the reasons it has emerged from a form of spontaneous theatre that involves playfulness and creativity to an important tool to effect behavioural change in individuals and groups. We then review the literature on the effects of improv in ageing populations, with a focus on social, emotional and cognitive functioning. Finally, we make recommendations on designing improv-based interventions so that future research, using rigorous quantitative methods, larger sample sizes and randomised controlled trials, can expand the use of improv in addressing important factors related to autonomy and well-being in older adults.

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Physician Perspectives on Private Equity Investment in Health Care

Abstract: This survey study examines physician views toward private equity investment in health care.

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Perceptions of undergraduate medical students on artificial intelligence in medicine: mixed-methods survey study from Palestine.

Abstract: BACKGROUND: The current applications of artificial intelligence (AI) in medicine continue to attract the attention of medical students. This study aimed to identify undergraduate medical students' attitudes toward AI in medicine, explore present AI-related training opportunities, investigate the need for AI inclusion in medical curricula, and determine preferred methods for teaching AI curricula.METHODS: This study uses a mixed-method cross-sectional design, including a quantitative study and a qualitative study, targeting Palestinian undergraduate medical students in the academic year 2022-2023. In the quantitative part, we recruited a convenience sample of undergraduate medical students from universities in Palestine from June 15, 2022, to May 30, 2023. We collected data by using an online, well-structured, and self-administered questionnaire with 49 items. In the qualitative part, 15 undergraduate medical students were interviewed by trained researchers. Descriptive statistics and an inductive content analysis approach were used to analyze quantitative and qualitative data, respectively.RESULTS: From a total of 371 invitations sent, 362 responses were received (response rate=97.5%), and 349 were included in the analysis. The mean age of participants was 20.38±1.97, with 40.11% (140) in their second year of medical school. Most participants (268, 76.79%) did not receive formal education on AI before or during medical study. About two-thirds of students strongly agreed or agreed that AI would become common in the future (67.9%, 237) and would revolutionize medical fields (68.7%, 240). Participants stated that they had not previously acquired training in the use of AI in medicine during formal medical education (260, 74.5%), confirming a dire need to include AI training in medical curricula (247, 70.8%). Most participants (264, 75.7%) think that learning opportunities for AI in medicine have not been adequate; therefore, it is very important to study more about employing AI in medicine (228, 65.3%). Male students (3.15±0.87) had higher perception scores than female students (2.81±0.86) (p<0.001). The main themes that resulted from the qualitative analysis of the interview questions were an absence of AI learning opportunities, the necessity of including AI in medical curricula, optimism towards the future of AI in medicine, and expected challenges related to AI in medical fields.CONCLUSION: Medical students lack access to educational opportunities for AI in medicine; therefore, AI should be included in formal medical curricula in Palestine.

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Illumination matters Part II: advanced comparative analysis of flexible ureteroscopes in a kidney model by PEARLS.

Abstract: PURPOSE: The aim of the study was to evaluate illumination properties in an in-vitro kidney calyx model in saline.DESIGN AND METHODS: We evaluated a series of contemporary flexible ureteroscopes including the Storz Flex-Xc and Flex-X2s, Olympus V3 and P7, Pusen 7.5F and 9.2F, as well as OTU WiScope using a 3D-printed closed pink kidney calyx model, submerged in saline. A spectrometer was used for illuminance and color temperature measurements at different openings located at center (direct light), 45° (direct and indirect light) and 90°(indirect light) to the axis of the scope.RESULTS: Maximum illuminance was at the center opening for all scopes (range: 284 to 12,058lx at 50% brightness and 454 to 11,871lx at 100% brightness settings). The scope with the highest center illuminance (Flex-Xc) was 26 times superior to the scope with the lowest illuminance (Pusen 7.5Fr) at 100% brightness setting. For each scope, there was a peripheral illuminance drop ranging from -43 to -92% at 50% brightness and -43% to -88% at 100% brightness settings, respectively (all p<0.01). Highest drop was for the P7 and the Pusen 9.2F. All scopes had illuminance skew, except the V3. All scopes had a warm color temperature.CONCLUSION: Illumination properties vary between ureteroscopes in an enclosed cavity in saline, and differs at center vs 45° and 90° positions within scopes. Peripheral illuminance drop can be as high as -92%, which is undesirable. This may affect the choice of ureteroscope and light brightness settings used in surgery by urologists.

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Survival estimation of oral cancer using fuzzy deep learning.

Abstract: BACKGROUND: Oral cancer is a deadly disease and a major cause of morbidity and mortality worldwide. The purpose of this study was to develop a fuzzy deep learning (FDL)-based model to estimate the survival time based on clinicopathologic data of oral cancer.METHODS: Electronic medical records of 581 oral squamous cell carcinoma (OSCC) patients, treated with surgery with or without radiochemotherapy, were collected retrospectively from the Oral and Maxillofacial Surgery Clinic and the Regional Cancer Center from 2011 to 2019. The deep learning (DL) model was trained to classify survival time classes based on clinicopathologic data. Fuzzy logic was integrated into the DL model and trained to create FDL-based models to estimate the survival time classes.RESULTS: The performance of the models was evaluated on a test dataset. The performance of the DL and FDL models for estimation of survival time achieved an accuracy of 0.74 and 0.97 and an area under the receiver operating characteristic (AUC) curve of 0.84 to 1.00 and 1.00, respectively.CONCLUSIONS: The integration of fuzzy logic into DL models could improve the accuracy to estimate survival time based on clinicopathologic data of oral cancer.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

The National MD-PhD Program Outcomes Study: career paths followed by Black and Hispanic graduates.

Abstract: Previous studies on attrition from MD-PhD programs have shown that students who self-identify as Black are more likely to withdraw before graduating than Hispanic students and students not from groups underrepresented in medicine (non-UIM). Here, we analyzed data collected for the National MD-PhD Program Outcomes Study, a national effort to track the careers of over 10,000 individuals who have graduated from MD-PhD programs over the past 60 years. On average, Black trainees took slightly longer to graduate, were less likely to choose careers in academia, and were more likely to enter nonacademic clinical practice; although, none of these differences were large. Black graduates were also more likely to choose careers in surgery or internal medicine, or entirely forego residency, and less likely to choose pediatrics, pathology, or neurology. Among those in academia, average research effort rates self-reported by Black, Hispanic, and non-UIM alumni were indistinguishable, as were rates of obtaining research grants and mentored training awards. However, the proportion of Black and Hispanic alumni who reported having NIH research grants was lower than that of non-UIM alumni, and the NIH career development to research project grant (K-to-R) conversion rate was lower for Black alumni. We propose that the reasons for these differences reflect experiences before, during, and after training and, therefore, conclude with action items that address each of these stages.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Agricultural resilience and land-use from an Indus settlement in north-western India: Inferences from stable Carbon and Nitrogen isotopes of archaeobotanical remains

Abstract: Stable isotopic compositions of carbon and nitrogen (delta C-13, delta N-15) of archaeological grains/seeds recovered from different cultural layers of an Indus (Harappan) archaeological site 4MSR (29 degrees 12'87.2N; 73 degrees 9'421E; Binjor, western Rajasthan, India) provide insights into the Harappan agriculture between similar to 2900 to similar to 1800 BCE. The delta C-13 values were used to retrieve hydrological status, while delta N-15 values were used to gauge agricultural intensification. Isotopic data of grains/seeds were generated representing three Indus phases (i) Early phase (similar to 2900-2600 BCE), (ii) Transitional phase (similar to 2600-2500 BCE), and (iii) Mature phase (similar to 2500-1800 BCE). We find delta C-13 values of barley grains (winter crop) varied in overlapping ranges for all the three phases -21.34 parts per thousand +/- 1.9; -22.55 parts per thousand +/- 1.6 and -22.75 parts per thousand +/- 1.7 respectively (n=10 for each phase) indicating insignificant changes in hydrology for winter crops. For summer crops like cotton, average delta C-13 values for Transitional phase -23.44 parts per thousand +/- 1.8 were not significantly different from those of Mature phase -22.55 parts per thousand +/- 2.5. The delta N-15(barley) values varied in wider range, however, intra-phase variability appears to have overlapping values but showing overall increase from Early (7.72 parts per thousand +/- 1.8) to Mature phase (11.17 parts per thousand +/- 7.2) indicating a plausible agricultural intensification. We also measured delta C-13 of host soil organic matter (SOM) and sediment delta N-15 to assess regional environmental conditions. In contrast to the trends observed for archaeological grains/seeds, delta C-13(SOM) values showed a statistically significant enriching trend from Early (-23.54 parts per thousand +/- 1.4) to Mature phase (-20.40 parts per thousand +/- 1.9) hinting a growing aridity in the region. We surmise that Harappan farmers of western Rajasthan region might be managing arable hydrological conditions in their fields through agricultural interventions to continue agriculture practices despite growing aridity in the vicinity. The high proportion of water-demanding crop cotton during the Mature phase despite of changing environmental conditions, also corroborate our interpretation, possibly grown for the trade purposes.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

The biomedicalization of pregnancy prevention, neoliberal feminism, and college women's experiences of the contraceptive paradox.

Abstract: Research examining the contraceptive paradox has illuminated how contraception can be a source of empowerment for some and oppression for others. This study advances theorizing of the contraceptive paradox by illustrating how 45 young women experience contraception as both liberating and constraining due to a confluence of biomedicalization processes, gender inequality, and neoliberal feminism. Drawing on focus group data, we find that the biomedicalization of pregnancy prevention and neoliberal feminist discourse, in combination with experiences of social and economic privilege and gender inequality in fertility work, shape participants' interpretation of contraceptive technology as a key resource for individually liberating themselves from undesired pregnancy. At the same time, their experiences indicate prescription contraception plays an oppressive role in their lives. In addition to blaming themselves and their bodies for negative contraceptive side effects, participants take for granted that assuming sole responsibility for contraceptive use in their relationships with men is the price they must pay to feel free. The findings indicate that addressing a social problem using an individualized biomedical solution obscures the power that structural inequalities exert over pregnancy-capable people, including relatively privileged young women. As an expression of biopower, these dynamics prompted participants to emphasize distributive justice over social justice, foreclosing their engagement in collective action.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

A site formation history of Obishir-5, the earliest Neolithic site in the Fergana Valley (Kyrgyzstan)

Abstract: Obsihir-5 holds some of the earliest evidence for the utilization of livestock in the mountainous regions of Central Asia. However, direct evidence of herding is lacking at the site. Geoarchaeological investigations, including textural, geochemical, mineralogical and micromorphological methods, have focused on the reconstruction of site formation and the search for direct evidence of herding activities. The sedimentary sequence at Obishir-5 has been divided into three facies: (1) SU0-SU1 (Bronze Age and Middle Ages), (2) SU2-SU3 (Obishirian), and (3) SU4-SU5 (Mesolithic/Epipaleolithic). SU1 formed through colluvial processes and was reworked by human and human-related activities. It is likely that these activities included herding and burning. Given the presence of herbivore dung and trampling in the sedimentary record, SU1 could include fumier-style accumulation. SU2-SU3 formed from the accumulation of coarse debris and fine particles originating from colluvial processes, physical weathering, aeolian processes and anthropogenic activity, such as burning. The archaeological material, including bones, charcoal and herbivore dung is intermixed with geogenic sediments and shows evidence of reworking. SU4-SU5 formed from colluvial and aeolian processes with low sedimentation rate. Human activity here was of low intensity and sporadic. The study of the sedimentary record has shown evidence of the use of dung and wood as fuel during the Obishirian period. However, it is not clear whether the sediments represent fumier deposits and therefore herding, as they have been heavily reworked. Nevertheless, the study opens up perspectives for the presence of livestock at the site during the Obishirian occupation. The methodology employed has allowed the reconstruction of the site formation history.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Collaborating for Sustainable Access to Digital Art: A Project Overview

Abstract: This paper addresses the preservation approach chosen for a selected group of born-digital artworks connected to the web, here categorized under the term internet art. The three first cases that are part of the project Infrastructuur Duurzame Toegankelijkheid Digitale Kunst (Collaborative Infrastructure for Sustainable Access to Digital Art) researched by LIMA (a platform for media art based in Amsterdam) focused on how to analyse internet artworks. This case study-based research was conducted in collaboration with 16 collecting institutions based in The Netherlands. The growing number of internet artworks in collections has pushed the development of preservation initiatives that consider these works' fleeting nature, a consequence of their technical build and time-sensitive characteristics. The project aims to produce and share knowledge for these artworks' preservation and overall sustainability while making it available for other similar works. This paper addresses the research steps while assessing its rationale and utility. It starts by describing the case study and assesses how the methodology serves conservation standards. The paper documents an overall evaluation of methods and results, pointing out the applicability and practical relevance of this initiative, here evaluated with positive conclusions. This paper fits the project's mission concerning knowledge sharing and raising awareness for the preservation of internet artworks and is authored by a short-term PhD fellow at LIMA.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

The Provenance of Copper Materials for bronze chariot-horses Unearthed from Yang'an Han Tomb in Qionglai, Sichuan Province revealed by the lead isotope analysis and trace elements analysis

Abstract: A collection of bronze chariot-horses was discovered in the Yang'an Han tomb in Qionglai City, Sichuan Province. These bronzes was used as burial objects, symbolizing the high status of the tomb owner during his lifetime. To analyze the samples taken from the bronze chariot-horses, various scientific techniques were employed, including metallographic microscopy, scanning electron microscope energy dispersive (SEM-EDS), multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS), and inductively coupled plasma-atomic emission spectrometer (ICP-AES) were used to analyze samples from the bronze chariot-horses. Unlike most Han bronzes made of leaded tin-bronze, the bronze chariot-horses were crafted using copper and tin, and their metallographic structure revealed that they were cast. The origin of the copper material used for the bronze chariot-horses differed noticeably from that of bronzes excavated in the Sichuan area from the late Warring States period and Western Han period. Historical documents and archaeological findings suggested that the owners of the bronze chariot-horses were possibly vassals. As the Sichuan region was governed by the central government of the Western Han Dynasty through the establishment of prefectures and counties rather than through the enfeoffment system, the presence of the bronze chariot-horses in Yang'an Han tomb may be related to the family of Liu Yue (刘). The analysis of the lead isotope data indicated that the copper material likely originated from the southeastern Hebei and western Shandong, providing strong evidence for the link between the bronze chariot-horses and the family of Liu yue in terms of resource circulation.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

The impact of provider-patient communication skills on primary healthcare quality and patient satisfaction in rural China: insights from a standardized patient study.

Abstract: OBJECTIVES: In middle-income countries, poor physician-patient communication remains a recognized barrier to enhancing healthcare quality and patient satisfaction. This study investigates the influence of provider-patient communication skills on healthcare quality and patient satisfaction in the rural primary healthcare setting in China.METHODS: Data were collected from 504 interactions across 348 rural primary healthcare facilities spanning 21 counties in three provinces. Using the Standardized Patient method, this study measured physician-patient communication behaviors, healthcare quality, and patient satisfaction. Communication skills were assessed using the SEGUE questionnaire framework. Multivariate linear regression models and multivariate logistic regression models, accounting for fixed effects, were employed to evaluate the impact of physicians' communication skills on healthcare quality and patient satisfaction.RESULTS: The findings indicated generally low provider-patient communication skills, with an average total score of 12.2±2.8 (out of 24). Multivariate regression models, which accounted for physicians' knowledge and other factors, demonstrated positive associations between physicians' communication skills and healthcare quality, as well as patient satisfaction (P<0.05). Heterogeneity analysis revealed stronger correlations among primary physicians with lower levels of clinical knowledge or more frequent training.CONCLUSION: This study emphasizes the importance of prioritizing provider-patient communication skills to enhance healthcare quality and patient satisfaction in rural Chinese primary care settings. It recommends that the Chinese government prioritize the enhancement of provider-patient communication skills to improve healthcare quality and patient satisfaction.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Early functional factors for predicting outcome of independence in daily living after stroke: a decision tree analysis.

Abstract: OBJECTIVE: This study aimed to investigate the predictive functional factors influencing the acquisition of basic activities of daily living performance abilities during the early stages of stroke rehabilitation using classification and regression analysis trees.METHODS: The clinical data of 289 stroke patients who underwent rehabilitation during hospitalization (164 males; mean age: 62.2±13.9 years) were retrospectively collected and analysed. The follow-up period between admission and discharge was approximately 6 weeks. Medical records, including demographic characteristics and various functional assessments with item scores, were extracted. The modified Barthel Index on discharge served as the target outcome for analysis. A good outcome was defined as a modified Barthel Index score ≥75 on discharge, while a modified Barthel Index score <75 was classified as a poor outcome.RESULTS: Two classification and regression analysis tree models were developed. The first model, predicting activities of daily living outcomes based on early motor functions, achieved an accuracy of 92.4%. Among patients with a good outcome, 70.9% exhibited (i) ≥4 points in the sitting-to-standing category in the motor assessment scale and (ii) 32 points on the Berg Balance Scale score. The second model, predicting activities of daily living outcome based on early cognitive functions, achieved an accuracy of 82.7%. Within the poor outcome group, 52.2% had (i) ≤21 points in the visuomotor organization category of Lowenstein Occupational Therapy Cognitive Assessment, (ii) ≤1 point in the time orientation category of the Mini Mental State Examination.CONCLUSION: The ability to perform sitting-to-standing and visuomotor organization functions at the beginning of rehabilitation emerged as the most significant predictors for achieving successful basic activities of daily living on discharge after stroke.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Do cultural and individual values influence sustainable tourism and pro-environmental behavior? Focusing on Chinese millennials

Abstract: This study investigated the Chinese millennials' perspectives of tourism sustainability using Hofstede's five-dimensional model. It examined the relationship between their environmental attitudes and hedonic/utilitarian values. According to the findings, collectivism had a positive impact on their pro-environmental attitude, evident in both their preferences and behaviors. Large power distance as well as high tolerance for uncertainty, conversely, resulted in a less pro-environmental attitude. Simultaneously, their masculinity, as expressed in their tendency to obtain more profit in advance, was harmful. This research adds to a greater understanding of cultural and individual values and suggests marketing strategies to advocate for environmentally conscious behaviors.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Response to Bryan Mercurio's Caveat Emptor

Abstract: Bryan Mercurio's brief accurately describes the inflection point of the global trading system as world governments retreat from free and fair trade. Chief among them is the United States, whose recent reversal is sending shockwaves throughout the rules-based economic world order. The United States' conflation of trade policy vis-a-vis China and national security, as well as the use of trade policy to garner political support from voters disenfranchised by the global trading system, have given way to industrial subsidies and protectionist tendencies. This article aims to build upon Mercurio's points and identify the underlying causes and long-term consequences of the current US direction. In addition, this piece differs from Dr Mercurio's assertions on three critical aspects of today's trade landscape. Firstly, industrial policy and economic security measures were first undertaken by China, and the United States and allied nations only followed suit. Secondly, the current US economic policy regarding China is severely constrained by today's political landscape, and the Biden administration's approach is moderate given these confines. Lastly, despite challenges, low-income countries can gain from the diversification movement as production shifts away from China.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Health impacts of war: case studies of New Zealand veterans of the First World War.

Abstract: AIM: Armed conflict remains a tragic feature of the modern world and so it is necessary to continue to study its health impacts. Even the study of historical conflicts is relevant given that certain health impacts are common to most wars e.g., post-traumatic stress disorder (PTSD).METHODS: This study built on a previous quantitative analysis of a randomly selected group of 200 New Zealand veterans from the First World War (WWI). From this sample we selected 10 cases that illustrated particular themes around morbidity impacts.RESULTS: The theme of severity of impacts was illustrated with a case who was severely wounded and died from suicide when back in New Zealand, and another case with severe PTSD. The theme of the high frequency of non-fatal conditions was revealed with cases illustrating new diagnoses (a case with n=8 diagnoses), hospitalisations for new conditions (n=6), non-fatal injury events (n=3) and for sexually transmitted infections (n=3). The theme of chronic debility as a consequence of various conditions was illustrated with cases who had suffered from being gassed or having gastroenteritis, malaria or pandemic influenza.CONCLUSION: These 10 selected cases reiterate how severe and extensive the morbidity burden for military personnel in WWI could be. Also illustrated is how the morbidity could contribute to adverse impacts on some of their lives after returning to New Zealand.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Effect of hydrodynamic and ecosystem conditions on persistent organic pollutant temporal-spatial variations in the Yellow Sea.

Abstract: Coastal seas are important pools of persistent organic pollutants (POPs) discharged from land. Considering the complex conditions in coastal seas and various biochemical features of POPs, special temporal-spatial variations in POPs have been reported. To understand these variations, we developed a three-dimensional hydrodynamic-ecosystem-POP coupled model and applied it to the Yellow Sea. We selected two POP species (polychlorinated biphenyl congener 153 (PCB-153) and decabromodiphenyl ether (BDE-209)), which have different biochemical properties, as target materials. The dissolved PCB-153 simulated concentration was high in late spring and low in autumn, whereas that of BDE-209 was high in summer and low in winter. Both PCB-153 and BDE-209 showed high particle-bound concentrations in early spring. In summer, dissolved PCB-153 accumulated at the sea bottom, whereas dissolved BDE-209 accumulated at the sea surface. Seasonal and spatial variation differences in the two POPs are likely caused by greater Henry's Law Constant (H') and bioconcentration factor (BCF) of PCB-153 than that of BDE-209, which leads to higher volatilization and stronger absorption by the particles for PCB-153 than BDE-209. As a component of such differences, the biological pump of PCB-153 in the central Yellow Sea is more apparent than that of BDE-209.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

State laws addressing teen dating violence in US high schools: A difference-in-differences study.

Abstract: OBJECTIVE: Teen dating violence (TDV) is prevalent with lifelong adverse consequences, and strategies to reduce its burden are needed. Many U.S. states have enacted laws to address TDV in schools, but few studies have examined their effectiveness. This study aimed to assess whether state TDV laws were associated with changes in physical TDV victimization among high school students.METHODS: We used repeated cross-sectional data of high school students from the Youth Risk Behavior Survey across 41 states from 1999 to 2019. Using a difference-in-differences approach with an event study design, we compared changes in past-year physical TDV in states that enacted TDV laws (n=21) compared to states with no required laws (n=20). Analyses accounted for clustering at the state-level and state and year-fixed effects. We conducted sensitivity analyses to assess the robustness of our findings.RESULTS: In our sample of 1,240,211 students, the prevalence of past-year physical TDV was 9.2% across all state-years. In 1999, the prevalence of TDV at the state-level ranged from 7.5 to 13.0%; in 2019, the prevalence ranged from 3.7 to 10.5%. There was no significant association between TDV laws and past-year physical TDV. Six or more waves after enactment, we observed a non-significant 1.7% percentage point reduction in TDV in states with TDV laws (95% CI: -3.6 to 0.3 percentage points; p=0.10).CONCLUSIONS: We found no significant association between enactment of TDV laws and physical TDV among high school students. Further research is needed to understand how TDV laws are implemented and components of TDV laws that may influence effectiveness.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Rational representations of uncertainty: a pluralistic approach to bounded rationality

Abstract: An increasingly prevalent approach to studying human cognition is to construe the mind as optimally allocating limited cognitive resources among cognitive processes. Under this bounded rationality approach (Icard in Philos Sci 85(1):79-101, 2018; Simon in Utility and probability, Palgrave Macmillan, 1980), it is common to assume that resource-bounded cognitive agents approximate normative solutions to statistical inference problems, and that much of the bias and variability in human performance can be explained in terms of the approximation strategies we employ. In this paper, we argue that this approach restricts itself to an unnecessarily narrow scope of cognitive models, which limits its ability to explain how humans flexibly adapt their representations to novel environments. We argue that more attention should be paid to how we form our cognitive representations in the first place, and advocate for pluralistic framework which jointly optimizes over both representations and algorithms for manipulating them. We identify several fundamental trade-offs that manifest in this joint optimization, and draw on recent work to motivate a unified formal framework for this analysis. We illustrate a simplified version of this analysis with a case study in social cognition, and outline several new directions for research that this approach suggests.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Introducing: Ulrich J. Lorenz, Radoslav I. Enchev, Clare F. Megarity, Helen Ginn, Patrick Rabe, Alice R. Walker, and Kartik Ayyer.

Abstract: In this Voices article we introduce seven impressive young group leaders who spoke at the recent Ringberg Workshop on Structural Biology organized by Ilme Schlichting from the Max Planck Institute for Medical Research, Heidelberg. We asked them to tell us more about their careers and their exciting research.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Sex-Associated Metabolites and Incident Stroke, Incident Coronary Heart Disease, Hypertension, and Chronic Kidney Disease in the REGARDS Cohort.

Abstract: BACKGROUND: Sex disparities exist in cardiometabolic diseases. Metabolomic profiling offers insight into disease mechanisms, as the metabolome is influenced by environmental and genetic factors. We identified metabolites associated with sex and determined if sex-associated metabolites are associated with incident stoke, incident coronary heart disease, prevalent hypertension, and prevalent chronic kidney disease.METHODS AND RESULTS: Targeted metabolomics was conducted for 357 metabolites in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) case-cohort substudy for incident stroke. Weighted logistic regression models were used to identify metabolites associated with sex in REGARDS. Sex-associated metabolites were replicated in the HyperGEN (Hypertension Genetic Epidemiology Network) and using the literature. Weighted Cox proportional hazard models were used to evaluate associations between metabolites and incident stroke. Cox proportional hazard models were used to evaluate associations between metabolites and incident coronary heart disease. Weighted logistic regression models were used to evaluate associations between metabolites and hypertension and chronic kidney disease. Fifty-one replicated metabolites were associated with sex. Higher levels of 6 phosphatidylethanolamines were associated with incident stroke. No metabolites were associated with incident coronary heart disease. Higher levels of uric acid and leucine and lower levels of a lysophosphatidylcholine were associated with hypertension. Higher levels of indole-3-lactic acid, 7 phosphatidylethanolamines, and uric acid, and lower levels of betaine and bilirubin were associated with chronic kidney disease.CONCLUSIONS: These findings suggest that the sexual dimorphism of the metabolome may contribute to sex differences in stroke, hypertension, and chronic kidney disease.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Resilience Curriculum Improves Skills of Pediatric Fellows in Delivery of Difficult News.

Abstract: BACKGROUND: Delivering difficult news to families is an essential but challenging skill. Pediatric trainees report limited confidence in this skill and perform poorly in simulation. We implemented the American Academy of Pediatrics (AAP) Resilience Curriculum and evaluated performance and self-efficacy in delivering difficult news.METHODS: The AAP Resilience Curriculum, using the SPIKES (Set-up, Perception, Invitation, Knowledge, Empathy, and Summary) framework, was taught to pediatric fellows. Fellows' performance during simulations with standardized patients before and after curriculum implementation was scored with a SPIKES checklist. Pre- and post-test surveys assessed self-efficacy in delivering difficult news.RESULTS: Fellows (n=19) significantly improved their performance in delivering difficult news, increasing the median SPIKES checklist scores from 78% to 90% completion (P<0.001). Pediatric fellows (n=35) reported improved confidence from 3.4/5 to 3.9 (P=0.01).CONCLUSIONS: Pediatric fellows demonstrated significant improvement in their ability to deliver difficult news during a simulated patient encounter and reported increased self-efficacy in delivering difficult news.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Polystyrene microplastics promote intestinal colonization of Aeromonas veronii through inducing intestinal microbiota dysbiosis

Abstract: The premise that pathogen colonized microplastics (MPs) can promote the spread of pathogens has been widely recognized, however, their role in the colonization of pathogens in a host intestine has not been fully elucidated. Here, we investigated the effect of polystyrene MPs (PS-MPs) on the colonization levels of Aeromonas veronii, a typical aquatic pathogen, in the loach (Misgurnus anguillicaudatus) intestine. Multiple types of MPs were observed to promote the intestinal colonization of A. veronii, among which PS-MPs exhibited the most significant stimulating effect (67.18% increase in A. veronii colonization). PS-MPs inflicted serious damage to the intestinal tracts of loaches and induced intestinal microbiota dysbiosis. The abundance of certain intestinal bacteria with resistance against A. veronii colonization decreased, with Lactococcus sp. showing the strongest colonization resistance (73.64% decline in A. veronii colonization). Fecal microbiota transplantation was performed, which revealed that PS-MPs induced intestinal microbiota dysbiosis was responsible for the increased colonization of A. veronii in the intestine. It was determined that PS-MPs reshaped the intestinal microbiota community to attenuate the colonization resistance against A. veronii colonization, resulting in an elevated intestinal colonization levels of A. veronii.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

High SARS-CoV-2 incidence and asymptomatic fraction during Delta and Omicron BA.1 waves in The Gambia.

Abstract: Little is known about SARS-CoV-2 infection risk in African countries with high levels of infection-driven immunity and low vaccine coverage. We conducted a prospective cohort study of 349 participants from 52 households in The Gambia between March 2021 and June 2022, with routine weekly SARS-CoV-2 RT-PCR and 6-monthly SARS-CoV-2 serology. Attack rates of 45% and 57% were seen during Delta and Omicron BA.1 waves respectively. Eighty-four percent of RT-PCR-positive infections were asymptomatic. Children under 5-years had a lower incidence of infection than 18-49-year-olds. One prior SARS-CoV-2 infection reduced infection risk during the Delta wave only, with immunity from ≥2 prior infections required to reduce the risk of infection with early Omicron lineage viruses. In an African population with high levels of infection-driven immunity and low vaccine coverage, we find high attack rates during SARS-CoV-2 waves, with a high proportion of asymptomatic infections and young children remaining relatively protected from infection.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Spotlight on the vertical migration of aged microplastics in coastal waters.

Abstract: Coastal waters are complex and dynamic areas with unique environmental attributes that complicate the vertical migration of microplastics (MPs). The MPs that enter coastal waters from diverse sources, including terrestrial, riverine, oceanic, and shoreline inputs undergo various aging pathways. In this study, the variations in the physiochemical characteristics of MPs undergoing various aging pathways and their vertical migration under dynamic conditions subjected to the effects of different MP characteristics and coastal environmental features were comprehensively explored. Opposite effects of aging on the vertical migration of hydrophobic and hydrophilic MPs were observed, with aging appearing to promote the dispersion of hydrophobic MPs but enhance the vertical migration of hydrophilic ones. The positive role of salinity and the negative role of humic acid (HA) concentrations on MP vertical migration were identified, and the mechanisms driving these effects were analyzed. Notably, intense turbulence not only promoted the floating of positively buoyant MPs but also reversed the migration direction of negatively buoyant MPs from downward to upward. Aging-induced changes in MP characteristics had a limited effect on MP vertical migration. The inherent characteristics of MPs and the surrounding environmental features, however, played major roles in their vertical migration dynamics. ENVIRONMENTAL IMPLICATION: Microplastics (MPs) have emerged as a significant global environmental concern and the coastal zones are the hotspots for MP pollution due to their high population density. This study comprehensively investigated the variations in the physiochemical characteristics of MPs undergoing various aging pathways. Their vertical migration patterns under dynamic conditions subjected to the effects of different MP characteristics and coastal environmental features were revealed. The roles of turbulence and MP density in their migration were identified. The findings of this study have important implications for understanding the transport and determining the ecological risks of MPs in coastal waters.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Roles of beta-catenin in innate immune process and regulating intestinal flora in Qi river crucian carp (Carassius auratus).

Abstract: In mammals, beta-catenin participates in innate immune process through interaction with NF-kappaB signaling pathway. However, its role in teleost immune processes remains largely unknown. We aimed to clarify the function of beta-catenin in the natural defense mechanism of Qi river crucian carp (Carassius auratus). beta-catenin exhibited a ubiquitous expression pattern in adult fish, as indicated by real-time PCR analysis. Following lipopolysaccharide (LPS), Polyinosinic-polycytidylic acid (polyI: C) and Aeromonas hydrophila (A. hydrophila) challenges, beta-catenin increased in gill, intestine, liver and kidney, indicating that beta-catenin likely plays a pivotal role in the immune response against pathogen infiltration. Inhibition of the beta-catenin pathway using FH535, an inhibitor of Wnt/beta-catenin pathway, resulting in pathological damage of the gill, intestine, liver and kidney, significant decrease of innate immune factors (C3, defb3, LYZ-C, INF-gamma), upregulation of inflammatory factors (NF-kappaB, TNF-alpha, IL-1, IL-8), and downregulation of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) activities, increase of Malondialdehyde (MDA) content. Following A. hydrophila invasion, the mortality rate in the FH535 treatment group exceeded that of the control group. In addition, the diversity of intestinal microflora decreased and the community structure was uneven after FH535 treatment. In summary, our findings strongly suggest that beta-catenin plays a vital role in combating pathogen invasion and regulating intestinal flora in Qi river crucian carp.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Philosophical Reflections on Teachers' Ethical Dilemmas in a Global Pandemic

Abstract: The COVID-19 pandemic raised not only overwhelming practical challenges but also deep ethical dilemmas for educators. There have been few efforts to connect these challenges to either ethical dilemmas teachers faced in pre-pandemic times or to philosophical analyses of complex normative terrain of teachers' work. We facilitated eleven discussion groups with 101 educators from seven countries on the dilemmas they faced due to COVID-19. Analysis of these sessions reveals how the pandemic amplified, exacerbated and augmented pre-pandemic educational dilemmas in ways that recalibrated teachers' core values and beliefs, and highlights the importance of engaging teachers in ethical dialogue.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Armed conflict, insecurity, and attitudes toward women's and girls' reproductive autonomy in Nigeria.

Abstract: BACKGROUND: Armed conflict and insecurity have been linked to deteriorations in reproductive health and rights globally. In Nigeria, armed violence has taken a significant toll on women's and girls' health and safety. However, knowledge is limited about how conflict shapes attitudes surrounding their ability to make autonomous decisions on relationships and childbearing. Drawing on a socioecological framework and terror management theory, we aimed to investigate the association between conflict, insecurity, and attitudes toward women's and girls' reproductive autonomy in Nigeria.METHODS: We conducted a cross-sectional study using data from two sources: the World Values Survey (WVS) and the Uppsala Conflict Data Program-Georeferenced Event Dataset (UCDP-GED). Nationally representative data on attitudes of 559 men and 534 women was collected by WVS in 2017-2018. Linear probability models estimated the association between attitudes toward five dimensions of women and girl's reproductive autonomy (contraception, safe abortion, marital decision-making, delayed childbearing, early marriage), respondents' perceptions of neighborhood insecurity using WVS data, and geospatial measures of conflict exposure drawn from UCDP-GED.RESULTS: Exposure to armed conflict and perceived neighborhood insecurity were associated with more supportive attitudes toward access to safe abortion among both men and women. Among women, conflict exposure was associated with higher support for contraception and the perception that early marriage can provide girls with security. Conflict-affected men were more likely to support a delay in girls' childbearing.CONCLUSION: Our findings suggest that conflict and insecurity pose a threat to, but also facilitate opportunities for, women's and girls' reproductive autonomy. Contraception, abortion, early marriage, and postponement or childbearing may be perceived as risk-aversion strategies in response to mortality threats, livelihood losses, and conflict-driven sexual violence. Our findings foreshadow changes in fertility and relationship patterns in conflict-affected Nigeria and highlight the need for health programming to ensure access to contraception and safe abortion services.

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Study on fracture characteristics and mechanisms of red sandstone under high-voltage pulse discharge

Abstract: To investigate the influences of geometrical size and discharge voltage of the pulse discharge equipment on the fracture characteristics and mechanisms of sandstone under high-voltage pulses, a series of experiments was conducted using a high-voltage pulse discharge device on sandstone circular disc specimens of sandstone with a thickness of 10 mm. These experiments covered a range of disc diameters ranging from 50 mm to 142 mm and discharge voltages from 15 kV to 40 kV. Through these experiments, the fracture characteristics of sandstone at both macroscopic and microscopic levels were investigated. In the experiments, a quantitative analysis of surface fracture was undertaken based on fracture density and fractal damage. Additionally, using the principle of energy equivalence, numerical simulation methods were used to study the damage evolution process in sandstone. The research results indicate that the formation and distribution of fractures in the sandstone specimens are significantly affected by geometrical size and discharge voltage. By analyzing the interaction between stress waves and fracture propagation, combined with indoor experimental results, the fracture mechanism was revealed. The high temperature and shock wave generated by the plasma channel leads to the crushing zone near the electrode, while the circumferential tensile component of the stress wave can result in radial fractures, and the reflected tensile wave leads to circumferential and radial fractures near the boundary.

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Prevailing of HPV-16 and 52 genotype in 2022-2023 in Sanandaj, Iran.

Abstract: INTRODUCTION: Human papillomavirus (HPV) presents a potential threat to the onset of carcinogenesis in the cervix, anogenital regions, and oropharynx. HPV encompasses over 200 types, with at least 12 having the potential to cause cancer, impacting the majority of sexually active individuals. In this current research, we explore the occurrence and spread of HPV genotypes.MATERIAL AND METHODS: During this cross-sectional study conducted in Sanandaj, Iran from Feb 2022 to Aug 2023, diverse samples including oral, vaginal, and genital were collected from individuals referred to private laboratories in Sanandaj, Iran. After sample collection and DNA extraction (FAVORGEN, Taiwan), they were subjected to PCR and genotyping (MehrViru, Iran). The subsequent statistical analysis unveiled infection rates across different demographics and age groups. STATA (version 17) were used for statistical analysis. We examined infection rates across demographics using t-tests and Odds Ratio.RESULTS: Overall, 26% (249) out of 950 cases tested positive for HPV, with 69% of these classified as high-risk. Among the examined population, 98% (933) were female, and 2% (17) were male. Females aged 31-40 exhibited the highest percentage of HPV prevalence (115/460) in the study with the majority of positive cases belonging to HR genotypes. The overall most frequent genotypes identified were 6, 16, 52, 53, 51, 58, and 56. HPV-16 exhibited the highest frequency among HR genotypes, accounting for 42 (17%) occurrences, followed by HPV-52 with a frequency of 32 (13%).CONCLUSION: Our findings emphasize the significant prevalence of HPV among females, particularly in the 21-30 age group. The identification of high-risk genotypes, underscores the importance of targeted interventions for specific age cohorts. The age-stratified analysis highlights a consistent predominance of high-risk HPV across age groups, indicating the need for age-specific preventive measures. These results contribute valuable information for designing effective screening and vaccination strategies, to alleviate the impact of diseases associated with HPV.

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Association of diabetic retinopathy on all-cause and cause-specific mortality in older adults with diabetes: National Health and Nutrition Examination Survey, 2005-2008.

Abstract: To evaluate the effect of diabetic retinopathy (DR) status or severity on all-cause and cause-specific mortality among diabetic older adults in the United States using the most recent National Health and Nutrition Examination Survey (NHANES) follow-up mortality data. The severity of DR was graded according to the Early Treatment Diabetic Retinopathy Study (ETDRS) grading scale. Multiple covariate-adjusted Cox proportional hazards regression models, Fine and Gray competing risk regression models, and propensity score matching (PSM) methods were used to assess the risk of all-cause and cause-specific mortality in individuals with diabetes. All analyses adopted the weighted data and complex stratified design approach proposed by the NHANES guidelines. Time to death was calculated based on the time between baseline and date of death or December 31, 2019, whichever came first. Ultimately 1077 participants, representing 3,025,316 US non-hospitalized individuals with diabetes, were included in the final analysis. After a median follow-up of 12.24years (IQR, 11.16-13.49), 379 participants were considered deceased from all-causes, with 43.90% suffering from DR, including mild DR (41.50%), moderate to severe DR (46.77%), and proliferative DR (PDR) (67.21%). DR was associated with increased all-cause, cardiovascular disease (CVD) and diabetes mellitus (DM)-specific mortality, which remained consistent after propensity score matching (PSM). Results of DR grading assessment suggested that the presence of mild, moderate to severe NPDR was significantly associated with increased risk of all-cause and CVD-specific mortality, while the presence and severity of any DR was associated with increased DM-specific mortality, with a positive trend. The presence of DR in elderly individuals with diabetes is significantly associated with the elevated all-cause and CVD mortality. The grading or severity of DR may reflect the severity of cardiovascular disease status and overall mortality risk in patients with diabetes.

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Child torture victimization: Review of criminal statutes and medico-legal issues.

Abstract: A renowned group of pediatricians and an attorney with expertise in child abuse matters proposed a medical definition of intrafamilial child torture perpetrated by a caretaker in a landmark 2014 publication in the health sciences literature. Representing one of the most widely cited publications on non-politically motivated child torture to date, this medical definition encompassing physical abuse, psychological abuse, deprivation, and neglect characterizing child torture has been broadly recognized and accepted by multidisciplinary professionals across medical, child welfare, and criminal justice sectors. While the medical community's efforts aimed to compel legislative changes, including adoption of explicit torture-specific statutes that would enable criminal justice system responses reflective of abuse severity, subsequent legal analyses have revealed tremendous variability in criminal investigations, prosecution, sentencing, and case outcomes. In this discussion piece, medico-legal issues relevant to intrafamilial child torture case prosecution are reviewed. The impact of the established medical definition on jurisdictional legal approaches and unique case challenges related to longitudinal nature of abuse, frequent psychological injury, and victim-perpetrator dynamics are explored in depth. Utilizing available legal research platforms, investigative information, health sciences literature, and prosecutor self-report, existing child torture statutes and case outcomes were compared with focus on perpetrator, victim, socio-environmental, and community influence on legal outcome. Prosecutorial challenges facing jurisdictions lacking child torture statutes are discussed with emphasis placed on the critical role played by the medical community to support diagnosis of physical and emotional impacts to the child. Finally, the process by which states can establish a jurisdictional torture statute are suggested.

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The urban political ecology of antimicrobial resistance: A critical lens on integrative governance.

Abstract: The objective of this paper is to integrate Urban Political Ecology (UPE) as a theory for identifying under-exposed urban dimensions of Antimicrobial Resistance (AMR). A UPE lens allows us to conceptualize urbanization as a ubiquitous socio-ecological process and an interpretive frame that could inform AMR governance strategies across related contexts by: a) situating AMR risks in relation to urbanization processes shaping social and political co-determinants of such systemic threats as climate change; b) aligning UPE scholarship with One Health (OH) approaches that address AMR to reveal the under-exposed link of AMR to environmental threats and broader structural dimensions that influence these threats; and c) identifying shared AMR and environmental governance pathways that inform the rationale for more equitable governance arrangements. We delineate a context in which the speed and scale of human activity in the larger context of urbanization, driven by global market integration strategies, impacts human-animal-environmental health threats such as AMR. We demonstrate how UPE scholarship can be leveraged to offer theoretical depth to approaches considering the interdependencies of AMR and climate change threats. We then propose a strategic approach focused on identifying shared governance pathways and intersectoral accountability frameworks to address upstream structural drivers of AM-Environmental threats. The co-benefits of a UPE-informed framework to human-animal-environmental health that leverages enabling policy environments to foster a more collaborative, equitable and sustainable approach to address systemic global health threats are clarified. Just as the concept of health in all policies emphasized taking health implications into account in all public policy development, the integration of UPE in AMR governance arrangements would emphasize the need to take other sectors into account through an intersectoral whole-of-government approach that fosters shared AMR - climate change governance pathways.

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Risk of Cardiac Arrhythmias Among Climbers on Mount Everest

Abstract: Importance Arterial hypoxemia, electrolyte imbalances, and periodic breathing increase the vulnerability to cardiac arrhythmia at altitude. Objective To explore the incidence of tachyarrhythmias and bradyarrhythmias in healthy individuals at high altitudes. Design, Setting, and Participants This prospective cohort study involved healthy individuals at altitude (8849 m) on Mount Everest, Nepal. Recruitment occurred from January 25 to May 9, 2023, and data analysis took place from June to July 2023. Exposure All study participants underwent 12-lead electrocardiogram, transthoracic echocardiography, and exercise stress testing before and ambulatory rhythm recording both before and during the expedition. Main Outcome The incidence of a composite of supraventricular (>30 seconds) and ventricular (>3 beats) tachyarrhythmia and bradyarrhythmia (sinoatrial arrest, second- or third-degree atrioventricular block). Results Of the 41 individuals recruited, 100% were male, and the mean (SD) age was 33.6 (8.9) years. On baseline investigations, there were no signs of exertional ischemia, wall motion abnormality, or cardiac arrhythmia in any of the participants. Among 34 individuals reaching basecamp at 5300 m, 32 participants climbed to 7900 m or higher, and 14 reached the summit of Mount Everest. A total of 45 primary end point-relevant events were recorded in 13 individuals (38.2%). Forty-three bradyarrhythmic events were documented in 13 individuals (38.2%) and 2 ventricular tachycardias in 2 individuals (5.9%). Nine arrhythmias (20%) in 5 participants occurred when climbers were using supplemental bottled oxygen, whereas 36 events (80%) in 11 participants occurred at lower altitudes when no supplemental bottled oxygen was used. The proportion of individuals with arrhythmia remained stable across levels of increasing altitude, while event rates per 24 hours numerically increased between 5300 m (0.16 per 24 hours) and 7300 m (0.37 per 24 hours) before decreasing again at higher altitudes, where supplemental oxygen was used. None of the study participants reported dizziness or syncope. Conclusion and Relevance In this study, more than 1 in 3 healthy individuals experienced cardiac arrhythmia during the climb of Mount Everest, thereby confirming the association between exposure to high altitude and incidence of cardiac arrhythmia. Future studies should explore the potential implications of these rhythm disturbances.

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Prognostic Models for Mortality and Morbidity in Heart Failure With Preserved Ejection Fraction

Abstract: Importance Accurate risk prediction of morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF) may help clinicians risk stratify and inform care decisions. Objective To develop and validate a novel prediction model for clinical outcomes in patients with HFpEF using routinely collected variables and to compare it with a biomarker-driven approach. Design, Setting, and Participants Data were used from the Dapagliflozin Evaluation to Improve the Lives of Patients With Preserved Ejection Fraction Heart Failure (DELIVER) trial to derive the prediction model, and data from the Angiotensin Receptor Neprilysin Inhibition in Heart Failure With Preserved Ejection Fraction (PARAGON-HF) and the Irbesartan in Heart Failure With Preserved Ejection Fraction Study (I-PRESERVE) trials were used to validate it. The outcomes were the composite of HF hospitalization (HFH) or cardiovascular death, cardiovascular death, and all-cause death. A total of 30 baseline candidate variables were selected in a stepwise fashion using multivariable analyses to create the models. Data were analyzed from January 2023 to June 2023. Exposures Models to estimate the 1-year and 2-year risk of cardiovascular death or hospitalization for heart failure, cardiovascular death, and all-cause death. Results Data from 6263 individuals in the DELIVER trial were used to derive the prediction model and data from 4796 individuals in the PARAGON-HF trial and 4128 individuals in the I-PRESERVE trial were used to validate it. The final prediction model for the composite outcome included 11 variables: N-terminal pro-brain natriuretic peptide (NT-proBNP) level, HFH within the past 6 months, creatinine level, diabetes, geographic region, HF duration, treatment with a sodium-glucose cotransporter 2 inhibitor, chronic obstructive pulmonary disease, transient ischemic attack/stroke, any previous HFH, and heart rate. This model showed good discrimination (C statistic at 1 year, 0.73; 95% CI, 0.71-0.75) in both validation cohorts (C statistic at 1 year, 0.71; 95% CI, 0.69-0.74 in PARAGON-HF and 0.75; 95% CI, 0.73-0.78 in I-PRESERVE) and calibration. The model showed similar discrimination to a biomarker-driven model including high-sensitivity cardiac troponin T and significantly better discrimination than the Meta-Analysis Global Group in Chronic (MAGGIC) risk score (C statistic at 1 year, 0.60; 95% CI, 0.58-0.63; delta C statistic, 0.13; 95% CI, 0.10-0.15; P < .001) and NT-proBNP level alone (C statistic at 1 year, 0.66; 95% CI, 0.64-0.68; delta C statistic, 0.07; 95% CI, 0.05-0.08; P < .001). Models derived for the prediction of all-cause and cardiovascular death also performed well. An online calculator was created to allow calculation of an individual's risk. Conclusions and Relevance In this prognostic study, a robust prediction model for clinical outcomes in HFpEF was developed and validated using routinely collected variables. The model performed better than NT-proBNP level alone. The model may help clinicians to identify high-risk patients and guide treatment decisions in HFpEF.

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Effects of the plastic additive 2,4-di-tert-butylphenol on intestinal microbiota of zebrafish

Abstract: Plastic additives such as the antioxidant 2,4-di-tert-butylphenol (2,4-DTBP) have been widely detected in aquatic environments, over a wide range of concentrations reaching 300 mu g/L in surface water, potentially threatening the health of aquatic organisms and ecosystems. However, knowledge of the specific effects of 2,4-DTBP on aquatic vertebrates is still limited. In this study, adult zebrafish were exposed to different concentrations of 2,4DTBP (0, 0.01, 0.1 and 1.0 mg/L) for 21 days in the laboratory. The amplicon sequencing results indicated that the diversity and composition of the zebrafish gut microbiota were significantly changed by 2,4-DTBP, with a shift in the dominant flora to more pathogenic genera. Exposure to 2,4-DTBP at 0.1 and 1.0 mg/L significantly increased the body weight and length of zebrafish, suggesting a biological stress response. Structural assembly defects were also observed in the intestinal tissues of zebrafish exposed to 2,4-DTBP, including autolysis of intestinal villi, adhesions and epithelial detachment of intestinal villi, as well as inflammation. The transcriptional expression of some genes showed that 2,4-DTBP adversely affected protein digestion and absorption, glucose metabolism and lipid metabolism. These results are consistent with the PICRUSt2 functional prediction analysis of intestinal microbiota of zebrafish exposed to 2,4-DTBP. This study improves our understanding of the effects of 2,4-DTBP on the health of aquatic vertebrates and ecosystems.

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Industrial and academic approaches to the search for alternative melatonin receptor ligands: An historical survey

Abstract: The search for melatonin receptor agonists formed the main part of melatonin medicinal chemistry programs for the last three decades. In this short review, we summarize the two main aspects of these programs: the development of all the necessary tools to characterize the newly synthesized ligands at the two melatonin receptors MT1 and MT2, and the medicinal chemist's approaches to find chemically diverse ligands at these receptors. Both strategies are described. It turns out that the main source of tools were industrial laboratories, while the medicinal chemistry was mainly carried out in academia. Such complete accounts are interesting, as they delineate the spirits in which the teams were working demonstrating their strength and innovative character. Most of the programs were focused on nonselective agonists and few of them reached the market. In contrast, discovery of MT1-selective agonists and melatonergic antagonists with proven in vivo activity and MT1 or MT2-selectivity is still in its infancy, despite the considerable interest that subtype selective compounds may bring in the domain, as the physiological respective roles of the two subtypes of melatonin receptors, is still poorly understood. Poly-pharmacology applications and multitarget ligands have also been considered.

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Joint association of TyG index and high sensitivity C-reactive protein with cardiovascular disease: a national cohort study.

Abstract: BACKGROUND: Both the triglyceride-glucose (TyG) index, as a surrogate marker of insulin resistance, and systemic inflammation are predictors of cardiovascular diseases; however, little is known about the coexposures and relative contributions of TyG index and inflammation to cardiovascular diseases. Using the nationally representative data from the China Health and Retirement Longitudinal Study (CHARLS), we conducted longitudinal analyses to evaluate the joint and mutual associations of the TyG index and high-sensitivity C-reactive protein (hsCRP) with cardiovascular events in middle-aged and older Chinese population.METHODS: This study comprised 8 658 participants aged at least 45years from the CHARLS 2011 who are free of cardiovascular diseases at baseline. The TyG index was calculated as Ln [fasting triglyceride (mg/dL)*fasting glucose (mg/dL)/2]. Cardiovascular events were defined as the presence of physician-diagnosed heart disease and/or stroke followed until 2018.We performed adjusted Cox proportional hazards regression and mediation analyses.RESULTS: The mean age of the participants was 58.6±9.0years, and 3988 (46.1%) were females. During a maximum follow-up of 7.0years, 2606 (30.1%) people developed cardiovascular diseases, including 2012 (23.2%) cases of heart diseases and 848 (9.8%) cases of stroke. Compared with people with a lower TyG index (<8.6 [median level]) and hsCRP<1mg/L, those concurrently with a higher TyG and hsCRP had the highest risk of overall cardiovascular disease (adjusted hazard ratio [aHR], 1.300; 95% CI 1.155-1.462), coronary heart disease (aHR, 1.294; 95% CI 1.130-1.481) and stroke (aHR, 1.333; 95% CI 1.093-1.628), which were predominant among those aged 70years or below. High hsCRP significantly mediated 13.4% of the association between the TyG index and cardiovascular disease, while TyG simultaneously mediated 7.9% of the association between hsCRP and cardiovascular risk.CONCLUSIONS: The findings highlight the coexposure effects and mutual mediation between the TyG index and hsCRP on cardiovascular diseases. Joint assessments of the TyG index and hsCRP should be underlined for the residual risk stratification and primary prevention of cardiovascular diseases, especially for middle-aged adults.

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Recovery of triethylamine and phosphoric acid from wastewater using a novel hybrid process of bipolar membrane electrodialysis and resin adsorption

Abstract: Triethylammonium phosphate wastewater, resulting from the absorption of triethylamine (TEA) exhaust gas by phosphoric acid, poses challenges in environmental protection. In this study, a novel combined process of bipolar membrane electrodialysis (BMED) and resin adsorption (RA) was proposed. Under the optimal conditions of 50 mA/cm2 and 5 cm/s, more than 96 % of the triethylammonium phosphate in real wastewater was converted into TEA and phosphoric acid during the BMED processes. Its current efficiency of 47 % and an energy consumption rate of 4.26 kWh/kg TEA. Furthermore, the low-concentration wastewater from BMED could be effectively treated through D001 resin at pH 2. Desorption of TEA loaded on D001 resin could be achieved using a 6 wt% phosphoric acid produced from the BMED process, and the concentrated desorption solution could be reprocessed through BMED process. The effluent of RA process could undergo chemical precipitation, thereby contained 18 mg/L COD, 0.43 mg/L TP and less than 3 mg/L TEA, meeting the first-class A standard of the Chinese GB18918-2002 Discharge standard of pollutants for municipal wastewater treatment plant. This novel strategy offered an innovative and environmentally friendly method for recycling this type of wastewater within ecological industries.

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A project-based view of urban dynamics: Analyzing 'leapfrogging' and fringe development in Israel

Abstract: Analyzing urban pattern dynamics based on construction projects, we classify them into three types - infilling, fringe, and leapfrogging, and focus on the role of leapfrogging projects as seeds for new developments, leading to uncontrolled urban sprawl. To study the leapfrogging phenomenon, we investigate the sprawl of three Israeli cities - Netanya, Haifa, and Safed over 54 years from 1964 to 2018 and conduct a country-wide analysis of the urban sprawl of all 66 Israeli municipalities between 2013 and 2018. Our analysis is based on a country-wide GIS database of roads, buildings, other infrastructure elements, and development plans, as well as high-resolution aerial photos covering the investigated areas and periods. We uncover and characterize a positive feedback mechanism of rapid leapfrogging developments that attract further developments in their proximity and emphasize the potential of leapfrogging development to force divergence from statutory development plans.

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Nitrogen fertiliser-domesticated microbes change the persistence and metabolic profile of atrazine in soil.

Abstract: Pesticides and fertilisers are frequently used and may co-exist on farmlands. The overfertilisation of soil may have a profound influence on pesticide residues, but the mechanism remains unclear. The effects of chemical fertilisers on the environmental behaviour of atrazine and their underlying mechanisms were investigated. The present outcomes indicated that the degradation of atrazine was inhibited and the half-life was prolonged 6.0 and 7.6 times by urea and compound fertilisers (NPK) at 1.0mg/g (nitrogen content), respectively. This result, which was confirmed in both sterilised and transfected soils, was attributed to the inhibitory effect of nitrogen fertilisers on soil microorganisms. The abundance of soil bacteria was inhibited by nitrogen fertilisers, and five families of potential atrazine degraders (Micrococcaceae, Rhizobiaceae, Bryobacteraceae, Chitinophagaceae, and Sphingomonadaceae) were strongly and positively (R >0.8, sig <0.05) related to the decreased functional genes (atzA and trzN), which inhibited hydroxylation metabolism and ultimately increased the half-life of atrazine. In addition, nitrogen fertilisers decreased the sorption and vertical migration behaviour of atrazine in sandy loam might increase the in-situ residual and ecological risk. Our findings verified the weakened atrazine degradation with nitrogen fertilisers, providing new insights into the potential risks and mechanisms of atrazine in the context of overfertilisation.

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AI-enabled Green Business Strategy: Path to carbon neutrality via environmental performance and green process innovation

Abstract: This study aims to comprehend and test the mediating effect of Green Process Innovation (GPI) and the moderating effect of Green Dynamic Capabilities (GDC) on Artificial Intelligence (AI) enabled Green Business Strategies (GBS) and Environmental Performance (EP) relationship. 252 manufacturing sector employees in North India participated in the data collection. The study used Structural equation modelling and Process Macro for investigating the hypothesized model. The results supported the hypothesized association between AIenabled GBS and EP. The study found that GPI mediate the constructive association between AI -enabled GBS and EP. GDC emerged as significant moderators for AI -enabled GBS and EP relationship. The article offers some helpful inputs for the Indian manufacturing industry to understand the importance of AI -enabled GBS in enhancing EP to move towards Carbon neutrality. The results suggest some practical implications for organizations wherein firms can maintain their focus on GPI at the organizational level by having AI -backed GBS, which will help the business achieve better EP. There is a scope to dig deep on comprehending the moderating impact of GDC in this context. The study recommends that GDC can further boost GPI, which will ultimately impact the firm's goal of carbon neutrality by shaping EP.

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COVID-19 vaccination communication: Effects of vaccine conspiracy beliefs and message framing among black and white participants.

Abstract: BACKGROUND: The importance of vaccination in combating the COVID-19 pandemic is widely acknowledged. The aim of this study was (1) to understand how one's vaccine conspiracy beliefs would influence their public health news processing, (2) to examine how specific public health news features (i.e., news frame) would influence message processing, and (3) to examine if there were any differences between Black and White participants in their message processing.METHODS: A nationwide online experiment (N=821) with a 3 (vaccine conspiracy beliefs: high vs. moderate vs. low)*2 (participants' race: Black vs. White)*2 (news frames: gain vs. loss) mixed-factorial design was conducted in the United States.RESULTS: Participants' level of vaccine conspiracy beliefs was predictive of their responses to outcome measures. Additionally, Black participants reported higher perceived message effectiveness, more favorable attitudes toward the message, and higher vaccination intentions than White participants. Furthermore, health news that emphasized vaccination benefits produced more favorable attitudes than those emphasizing losses associated with non-vaccination, especially for White participants. Lastly, participants reported more favorable attitudes toward gain-framed health news regardless of their vaccine conspiracy beliefs.CONCLUSION: It is crucial for health officials to work to find effective media message strategies to combat COVID-19 vaccine conspiracy theories and misinformation. Furthermore, this study supports the significance of health organizations' ongoing efforts to tailor public health messaging to specific racial groups, as evidenced by considerable variations in perceptions among Black and White Americans.

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Floristic changes and environmental drivers of soil fungi and archaea in different salt-tolerant plant communities in the intertidal habitat of coastal wetlands

Abstract: Microorganisms are crucial elements of terrestrial ecosystems, which play significant roles in improving soil physicochemical properties, providing plant growth nutrients, degrading toxic and harmful chemicals, and biogeochemical cycling. Variations in the types and quantities of root exudates among different plants greatly alter soil physicochemical properties and result in variations in the diversity, structure, and function of soil microorganisms. Not much is understood about the differences of soil fungi and archaea communities for different plant communities in coastal wetlands, and their response mechanisms to environmental changes. In this study, fungal and archaea communities in soils of Suaeda salsa, Phragmites australis, and Spartina alterniflora in the intertidal habitat of coastal wetlands were selected for research. Soil fungi and archaea were analyzed for diversity, community structure, and function using high throughput ITS and 16S rRNA gene sequencing. The study revealed significant differences in fungi and archaea's diversity and community structure in the rhizosphere soil of three plant communities. At the same time, there is no significant difference in the functional groups. SOM, TP, AP, MC, EC and SOM, TN, TP, AP, MC, EC are the primary environmental determinants affecting changes in soil fungal and archaeal communities, respectively. Variations in the diversity, community structure, and ecological functions of fungi and archaea can be used as indicators characterizing the impact of external disturbances on the soil environment, providing a theoretical foundation for the effective utilization of soil microbial resources, thereby achieving the goal of environmental protection and health promotion.

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Multipurpose animal utilization underpinned early Bronze Age subsistence of an oasis in an arid area of northwestern China

Abstract: The dispersal and development of pastoralism during the Bronze Age profoundly influenced human livelihoods and adaptability to diverse environments in northwestern China. Although diachronic changes in the composition of animal resources have been discussed, the specific utilization form of these resources remains unclear due to the lack of age-class and sex ratio data for inferring population structure. Here, we report new zooarchaeological data from the Haizang site dated between 4000 and 3500 cal. yr BP in an oasis in northwestern China's Hexi Corridor. The 7092 identified animal remains are dominated by sheep/goat (53.44%) and cattle (15.61%), supplemented by pig (11.96%) and wildlife (11.11%), representing the largest animal remains assemblage in this area thus far. The mortality age profiles of sheep/goat and cattle remains show that domesticated ruminants were utilized for multiple purposes, implying the introduction of livestock utilization knowledge alongside these species. During this stage, the reliance of local subsistence on ruminant pastoralism was geographically varied in and around the Hexi Corridor, although these areas shared similar Qijia cultural phenomena. We argue that ancient inhabitants of Haizang took a more ruminant-focused and multipurpose animal utilization strategy, which alleviated the survival pressure caused by colder and drier climate in the global context of '4.2 ka BP event' and underpinned local social development. The acceleration of trans-regional exchange across Eurasia during the early Bronze Age provided the paramount material and knowledge for this transformation.

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THE HISTORY OF ECONOMICS SOCIETY AT FIFTY: WHAT KIND OF DIVERSITY?

Abstract: My first acquaintance with the History of Economics Society (HES) occurred in the summer of 1990 when I attended its seventeenth annual meeting. Organized by the then HES president and now recently deceased Stanley Todd Lowry at Washington and Lee University in Lexington, Virginia, it marked the beginning of my experience with US higher education. Later that summer, I began a two-year post-doctoral fellowship at Harvard University. The economics department still hosted a history of economics seminar-the Kress seminar-though its actual connection with the seminar was tenuous.1 Following the Lexington meeting, the paper I presented was accepted for publication in volume 7 of Perspectives on the History of Economic Thought-a book series that published selected papers from the HES conference. It was my first publication in English. From then on, I kept attending the HES annual meeting regularly and with enthusiasm. I met a number of stimulating people and made some good friends there. It was always refreshing to find myself in the United States following nine months of teaching and research in France.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Numerical Simulation of Flowslide Considering Transient Seepage Flow and Progressive State Transition

Abstract: Flowslides are rapid gravity-driven flows of sediment-water mixture that typically occur following slope failures in soils, tailings, and municipal solid wastes, but the progressive state transition during the evolution of flowslides is still unclear. In this study, a practical method which couples elastic-plastic constitutive equations and Bingham fluid equations by a progressive transition criterion is developed within the framework of smoothed particle hydrodynamics (SPH). The elastic-plastic constitutive equations describe the mechanical behavior at a solid-like state and that at a fluid-like state is described by Bingham fluid equations. The progressive state transition can be described by a transition factor, which is governed by the degree of saturation and shear strain rate according to the experimental data. Transient seepage flow is also introduced into the SPH framework to describe the effect of water content on the evolution of flowslides. An infiltration boundary method based on ghost particles and smooth function symmetry is proposed to precisely model the rainfall infiltration process. The experimental data of ring shear tests and flume test are adopted to successfully verify the performance of the method, which can reasonably simulate the complicated solid-fluid transition processes. The method is further applied to simulate a full scale catastrophic flowslide at Payatas Landfill. As the overlying pressure on the slip surface increases, the material reaches the yield state. During the postfailure stage, the material at the slip surface first changes into an elastic-plastic state, and then partially transforms into a fluid-like state, leading to the large deformation of the failure material. The proposed method can contribute to a better understanding of the evolution of flowslides and is an applicable tool for hazard assessment.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Objective numeracy exacerbates framing effects from decision-making under political risk.

Abstract: While Prospect Theory helps to explain decision-making under risk, studies often base frames on hypothetical events and fail to acknowledge that many individuals lack the ability and motivation to engage in complex thinking. We use an original survey of US adults (N=2813) to test Prospect Theory in the context of the May 2023 debt ceiling negotiations in the US Congress and assess whether objective numeracy moderates framing effects. We hypothesize and find evidence to suggest that most respondents are risk-averse to potential gains and risk-accepting to potential losses; however, high numerates are more risk-averse and risk-accepting to gains and losses, respectively, than low numerates. We also find that need for cognition interacts with numeracy to moderate framing effects for prospective losses, such that higher need for cognition attenuates risk-acceptance among low numerates and exacerbates risk-acceptance among high numerates. Our results are robust to a range of other covariates and in models accounting for the interaction between political knowledge and need for cognition, indicating joint moderating effects from two knowledge domains similarly conditioned by the desire to engage in effortful thinking. Our findings demonstrate that those who can understand and use objective information may remain subjectively persuaded by certain policy frames.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Occurrence and fate of N-nitrosamines in full-scale domestic wastewater treatment plants and their impact on receiving waters along the Lijiang River, China

Abstract: Domestic wastewaters contaminated with N-nitrosamines pose a significant threat to river ecosystems worldwide, particularly in urban areas with riparian cities. Despite widespread concern, the precise impact of these contaminants on receiving river waters remains uncertain. This study investigated eight N-nitrosamines in wastewater treatment plants (WWTPs) and their adjacent receiving river, the Lijiang River in Guilin City, Southwest China. By analyzing thirty wastewater samples from five full-scale WWTPs and twenty-three river water samples from Guilin, we quantified the mass loads of N-nitrosamines discharged into the surrounding watershed via domestic effluents. The results revealed that N-nitrosodimethylamine (10-60 ng/L), N-nitro- sodiethylamine (3.4-22 ng/L), and N-nitrosopyrrolidine (not detected-4.5 ng/g) were predominant in influents, effluents, and sludge, respectively, with the overall removal efficiencies ranging from 17.7 to 65.6% during wastewater treatment. Cyclic activated sludge system and ultraviolet disinfection were effective in removing N-nitrosamines (rates of 59.6% and 24.3%), while chlorine dioxide disinfection promoted their formation. A total of 30.4 g/day of N-nitrosamine mass loads were observed in the Lijiang River water, with domestic effluents contributing about 31.3% (19.4 g/day), followed by livestock breeding wastewater (34.5%, 12.0 g/day), and unknown sources (24.7%, 7.5 g/day). These findings highlight the critical role of WWTPs in transporting N- nitrosamines to watersheds and emphasize the urgent need for further investigation into other potential sources of N-nitrosamine pollution within watersheds.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Australia II: A Case Study in Engineering Ethics.

Abstract: Australia II became the first foreign yacht to win the America's Cup in 1983. The boat had a revolutionary wing keel and a better underwater hull form. In official documents, Ben Lexcen is credited with the design. He is also listed as the sole inventor of the wing keel in a patent application submitted on February 5, 1982. However, as reported in New York Times, Sydney Morning Herald, and Professional Boatbuilder, the wing keel was in fact designed by engineer Peter van Oossanen at the Netherlands Ship Model Basin in Wageningen, assisted by Dr. Joop Slooff at the National Aerospace Laboratory in Amsterdam. Based on telexes, letters, drawings, and other documents preserved in his personal archive, this paper presents van Oossanen's account of how the revolutionary wing keel was designed. This is followed by an ethical analysis by Martin Peterson, in which he applies the American NSPE and Dutch KIVI codes of ethics to the information provided by van Oossanen. The NSPE and KIVI codes give conflicting advice about the case, and it is not obvious which document is most relevant. This impasse is resolved by applying a method of applied ethics in which similarity-based reasoning is extended to cases that are not fully similar. The key idea, presented in Peterson's book The Ethics of Technology (Peterson, The ethics of technology: A geometric analysis of five moral principles, Oxford University Press, 2017), is to use moral paradigm cases as reference points for constructing a moral map.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

A structural model of EFL teachers' physical activity, emotion regulation, and competence for online teaching.

Abstract: BACKGROUND: The COVID-19 pandemic has prompted a rapid shift to online teaching, placing unprecedented demands on educators' physical and mental well-being. However, the relationship between English as a Foreign Language (EFL) teachers' physical activity, emotion regulation, and competence for online teaching remains underexplored.OBJECTIVES: This study aimed to investigate the interplay between EFL teachers' physical activity, emotion regulation strategies, and competence for online teaching.RESULTS: Structural equation modeling revealed significant direct and indirect effects, indicating that physical activity positively influences emotion regulation, which, in turn, enhances teachers' competence for online instruction. Furthermore, emotion regulation was found to mediate the relationship between physical activity and online teaching competence.CONCLUSIONS: These findings underscore the importance of promoting physical activity among EFL teachers as a means to enhance their emotion regulation skills and competence for online teaching, particularly in the context of the COVID-19 pandemic.IMPLICATIONS: The study highlights the need for targeted interventions aimed at supporting EFL teachers' well-being and professional development, with implications for educational policies, teacher training programs, and institutional support structures in the digital learning landscape.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Extremism and Terrorism: Rebel Goals and Tactics in Civil Wars

Abstract: Extremism and terrorism are thought to go hand in hand in civil wars. Yet do they? Are rebel groups with more extreme goals more likely than moderate ones to use terrorism, as commonly assumed? Arguments linking extremism to terrorism are often circular: groups are tagged as extremist because they do extreme things. Our article addresses this problem by articulating a novel conceptualization of extremism as the distance of group goals from the status quo. Understanding the relationship between what groups want and how they try to achieve it has obvious theoretical and policy implications. We theorize mechanisms that might connect extremist goals to terrorism and use new data on rebel group aims in civil wars from 1970 to 2013 to examine the empirical relationship between extremism and terrorism in a nontautological way. The results show that some extremist goals are associated with terrorism but not others. Groups with goals that involve changing the political ideology of the state or transforming political power across identity groups are more likely to use terrorism or to use more of it. Secessionist groups, however, are no more likely to produce terrorism than are those with less extreme territorial aims such as autonomy.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Age-related changes in species-typical behaviours in the 5xFAD mouse model of Alzheimer's disease from 4 to 16 months of age.

Abstract: Alzheimer's disease (AD) patients show age-related decreases in the ability to perform activities of daily living and the decline in these activities is related to the severity of neurobiological deterioration underlying the disease. The 5xFAD mouse model of AD shows age-related impairments in sensory- motor and cognitive function, but little is known about changes in species-typical behaviours that may model activities of daily living in AD patients. Therefore, we examined species-typical behaviours used as indices of exploration (rearing) and compulsivity (grooming) across six tests of anxiety-like behaviour or motor function in female 5xFAD mice from 3 to 16 months of age. Robust decreases in rearing were found in 5xFAD mice across all tests after 9 months of age, although few differences were observed in grooming. A fine-scale analysis of grooming, however, revealed a previously unresolved and spatially restricted pattern of grooming in 5xFAD mice at 13-16 months of age. We then examined changes in species-typical behaviours in the home-cage, and show impaired nest building in 5xFAD mice at all ages tested. Lastly, we examined the relationship between reduced species typical behaviours in 5xFAD mice and the presentation of freezing behaviour, a commonly used measure of memory for conditioned fear. These results showed that along with cognitive and sensory-motor behaviour, 5xFAD mice have robust age-related impairments in species-typical behaviours. Therefore, species typical behaviours in 5xFAD mice may help to model the decline in activities of daily living observed in AD patients, and may provide useful behavioural phenotypes for evaluating the pre-clinical efficacy of novel therapeutics for AD.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Women are lean and men are also lean: nutrition titles in women's and men's health magazines.

Abstract: BACKGROUND: Whether nutrition messages in popular health magazines differ by country or season has seldom been studied. We assessed the nutrition topics featured in the headlines of Men's Health (MH) and Women's Health (WH) magazines from different countries.METHODS: We sampled MH and WH magazines from Portugal, South Africa, Spain, the UK and the USA. Nutrition-related headlines were categorized as weight loss, weight gain, micronutrients and other.RESULTS: The most frequent topics were Other (44%) and weight loss (41%), while micronutrients represented 4%. Topics related to weight gain were more frequent in MH (19% vs. 2% in WH), while no difference was found for weight loss (44% vs. 37% in WH). On multivariable analysis, weight gain had a higher likelihood of being present in MH than in WH, Odds ratio and (95% confidence interval): 8.3 (2.2-90.9), p=0.002, while no association was found for weight loss: OR 1.1 (0.6-2.0), p=0.80. Weight loss was absent from the US WH and present in two thirds of the Portuguese WH; in MH, weight gain was evenly distributed between countries. Prevalence of the weight loss topic was lower in March (15% vs. 54% in January, p<0.01 by logistic regression) and to a lesser degree in June (35%) and July (35%). No seasonality was found for the weight gain topic.CONCLUSION: In WH and MH magazines, nutrition topics vary according to gender, country, and season. Weight gain remains a male topic, while weight loss is equally prevalent in both women's and men's magazines.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Longitudinal attenuation in political polarization: Evidence from COVID-19 vaccination adherence in Brazil.

Abstract: BACKGROUND: While political polarization in policy opinions, preferences, and observance is well established, little is known about whether and how such divisions evolve, and possibly attenuate, over time. Using the COVID-19 pandemic in Brazil as the backdrop, we examine the longitudinal evolution of a highly relevant and polarizing policy: adherence to the COVID-19 vaccination.METHODS: Studies 1 (N=3346) and 2 (N=10,214) use nationwide surveys to document initial differences and subsequent changes in vaccination adherence between conservatives (Bolsonaristas) and non-conservatives (non-Bolsonaristas). Study 3 (N=742) uses an original dataset to investigate belief changes among conservatives and their association with asymmetric changes in vaccination adherence.RESULTS: Despite substantial differences at the early stages of rollout, the gap in vaccination adherence between conservatives and non-conservatives significantly decreased with the passage of time, driven essentially by a much faster uptake among the initially most skeptic-the conservatives. Study 3 demonstrates that the asymmetric changes in vaccination adherence were associated with meaningful belief changes among the conservatives, especially about the perceived effectiveness of the COVID-19 vaccines and the expected adherence of peers to the vaccination campaign.CONCLUSIONS: Together, these studies show that, in a context where the superiority of the promoted policy becomes clear over time and individuals have the opportunity to revisit prior beliefs, even intense political polarization can be attenuated.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Emigrant voyages from the UK to North America and Australasia, 1853-1913

Abstract: Studies of the determinants of emigration from Europe from 1850 to 1913 include the gains to migrants but often neglect the costs. One component of those costs is earnings forgone on the voyage. In this paper, I present new data on the voyage times for emigrants from the UK traveling to the United States and to Australia. Between 1853-7 and 1909-13 the voyage time from Liverpool to New York fell from 38 days to just 8 days (or 79 per cent). Over the same years, the emigrant voyage to Sydney fell by more in absolute terms, from 105 days to 46, but by less in relative terms (56 per cent). Differences in profiles of travel times are explained with a focus on the transition from sailing to steam ships and (for Australia) the use of the Suez Canal. Data series for fare prices and foregone wage costs during transit are combined to create new series on the 'total' cost of emigrant voyages. Econometric analysis of the determinants of UK emigration to the United States, Canada, and Australia supports the view that time costs mattered.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Does the conflict between work and family hinder thriving? Role of depersonalization and intrinsic motivation

Abstract: PurposeElucidating on the concrete outline of conservation of resource theory, this study aims to explore the links between work-family conflict and workplace thriving. In particular, this study has integrated depersonalization as a mediator and tested the moderated mediation effects of intrinsic motivation in work-family conflict and depersonalization relationships.Design/methodology/approachData were collected using a sample of 357 doctors working across various public hospitals in India over two waves (T1 and T2) and was tested using AMOS and Process Macros.FindingsExploration reveals that work-family conflict is negatively associated with workplace thriving. The mediating role of depersonalization in between work-family conflict and workplace thriving was established. Moreover, the moderating role of intrinsic motivation in work-family conflict and workplace thriving via depersonalization was also established.Originality/valueThe present study makes a theoretical addition to the literature by investigating nuances through which work-family conflict relationships and thriving at the workplace can be affected. To date, such a relationship has not been established. The study also extends the role of depersonalization as an underlying mechanism between work-family conflict and workplace thriving, making an imperative contribution. This study also tested the moderating role of intrinsic motivation. Overall, these relationships are novel and have been seldom reported.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Local government resilience in the face of Russian aggression: the case of Ukraine

Abstract: The collapse of a state during crises, such as large-scale wars, demands effective preventive measures. The 2014 military aggression by Russia in Ukraine triggered profound changes and emphasised the importance of strategic responses. So, the cutoff of Russian aggression was facilitated by the coordinated interaction of state authorities and local government and the increased autonomy of local government at the grassroots level, as a result of the successful decentralisation reform in Ukraine. After the full-scale Russian invasion in February 2022, the local government played a vital role in sustaining Ukrainian cities and villages. This paper examines local government operations in active conflict zones and during occupation, assessing their preparedness for military actions. It delves into the unique challenges faced and necessary post-war adjustments. Through in-depth interviews in the war-affected Kharkiv region and secondary sources, we illuminate crisis management within local government during wartime in Ukraine. Therefore, this study highlights the crucial role of local government bodies in addressing the issues of local residents during a wartime crisis.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Beyond cemeteries - excavation of a settlement of Poienesti-Lucaseuca Culture in Ivancea, Republic of Moldova

Abstract: The Poiene & scedil;ti-Luca & scedil;euca-culture (late 3(rd) to second half of the 1(st) century BC), which is distributed in the forest steppe between the east Carpathian Mountains and the river Dniestr, is seen as the result of an immigration of groups from the Jastorf area in North-East Germany. This concept is based on cemeteries: both the form of the grave4s and their material culture (ceramics, jewellery, costume) are foreign in the area, but show clear connections to the North and the North-West. Up to now large settlement excavations are missing that would allow for an evaluation of that concept based on settlement and economic structures as well as on the material culture of everyday life. The project that is presented here with first results, aims to that desideratum. With surveys and test excavations as a starting point on different sites in Central part of Republic of Moldova, the authors are excavating the Poienesti-Lucaseuca settlement of Ivancea-Sub Padure on a large scale. The project is funded by Deutsche Forschungsgemeinschaft. The paper presents first results like different post buildings and pit dwellings, the spectrum of small finds and a selection of the numerous ceramics including greek imports, and discusses the connectivity that becomes visible. The post buildings have no regional parallels and seem to have the best parallels in the Northwest. In opposite to that the small finds show a broad entanglement especially to the south and West and thus contradict the evidence from the grave. Also, in opposite to the graves the settlement ceramics show clear regional traditions, bus also relations to the North and the Northeast.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Coccidioidomycosis-Related Hospital Visits, Texas, USA, 2016-2021.

Abstract: We analyzed hospital discharge records of patients with coccidioidomycosis-related codes from the International Classification of Diseases, 10th revision, Clinical Modification, to estimate the prevalence of hospital visits associated with the disease in Texas, USA. Using Texas Health Care Information Collection data for 2016-2021, we investigated the demographic characteristics and geographic distribution of the affected population, assessed prevalence of hospital visits for coccidioidomycosis, and examined how prevalence varied by demographic and geographic factors. In Texas, 709 coccidioidomycosis-related inpatient and outpatient hospital visits occurred in 2021; prevalence was 3.17 cases per 100,000 total hospital visits in 2020. Geographic location, patient sex, and race/ethnicity were associated with increases in coccidioidomycosis-related hospital visits; male, non-Hispanic Black, and Hispanic patients had the highest prevalence of coccidioidomycosis compared with other groups. Increased surveillance and healthcare provider education and outreach are needed to ensure timely and accurate diagnosis and treatment of coccidioidomycosis in Texas and elsewhere.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Intensive exploitation of pheasants at the Early Holocene site of Xiaogao in Northern China

Abstract: During the Early Holocene, northern China witnessed revolutionary changes, such as the emergence of sedentary lifestyles, the domestication of animals and plants, the spread of pottery making, and a radical restructuring of social relationships. During this period, the avifauna became an increasingly significant component of the diversified small game resources. This paper presents the results of a study of remains of pheasants, assigned to Phasianinae, recovered at the Xiaogao site in Shandong Province, northern China. The data show that the occupants of Xiaogao seasonally hunted predominantly male pheasants and systematically butchered them. They became familiar with the ecology and ethology of pheasants, and they were able to consciously and purposefully intensify the utilization of pheasants to a maximum foraging efficiency. Animal exploitation behaviors are manifestations and results of niche-construction efforts by human societies. This emphasizes humans' capacity to actively exploit wild animal and plant resources and modify the environment and ecosystem to produce stable and sustainable subsistence economies.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Clinical Research in Renal Transplantation: A Bibliometric Perspective on a Half-century of Innovation and Progress.

Abstract: BACKGROUND: Groundbreaking biomedical research has transformed renal transplantation (RT) into a widespread clinical procedure that represents the mainstay of treatment for end-stage kidney failure today. Here, we aimed to provide a comprehensive bibliometric perspective on the last half-century of innovation in clinical RT.METHODS: The Web of Science Core Collection was used for a comprehensive screening yielding 123303 research items during a 50-y period (January 1973-October 2022). The final data set of the 200 most-cited articles was selected on the basis of a citation-based strategy aiming to minimize bias.RESULTS: Studies on clinical and immunological outcomes (n = 63 and 48), registry-based epi research (n = 38), and randomized controlled trials (n = 35) dominated the data set. Lead US authors have signed 110 of 200 articles. The overall level of evidence was high, with 84% of level1 and -2 reports. Highest numbers of these articles were published in New England Journal of Medicine , Transplantation , and American Journal of Transplantation. Increasing trend was observed in the number of female authors in the postmillennial era (26% versus 7%).CONCLUSIONS: This study highlights important trends in RT research of the past half-century. This bibliometric perspective identifies the most intensively researched areas and shift of research interests over time; however, it also describes important imbalances in distribution of academic prolificacy based on topic, geographical aspects, and gender.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Geographic information system-based determination of priority monitoring areas for hazardous air pollutants in an industrial city.

Abstract: Industrial cities are hotspots for many hazardous air pollutants (HAPs), which are detrimental to human health. We devised an identification method to determine priority HAP monitoring areas using a comprehensive approach involving monitoring, modeling, and demographics. The methodology to identify the priority HAP monitoring area consists of two parts: (1) mapping the spatial distribution of selected categories relevant to the target pollutant and (2) integrating the distribution maps of various categories and subsequent scoring. The identification method was applied in Ulsan, the largest industrial city in South Korea, to identify priority HAP monitoring areas. Four categories related to HAPs were used in the method: (1) concentrations of HAPs, (2) amount of HAP emissions, (3) the contribution of industrial activities, and (4) population density in the city. This method can be used to select priority HAP monitoring areas for intensive monitoring campaigns, cohort studies, and epidemiological studies.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Linking historical recipes and ageing mechanisms: the issue of 19th century iron gall inks

Abstract: Several manuscripts and drawings of our historical and artistic heritage have been produced with iron gall inks. To obtain an iron gall ink, ancient treatises cite the addition of ferrous sulphate and gum Arabic to a decoction of oak galls as a basic procedure. Owing to the development of synthetic chemistry, iron gall ink recipes were improved with new materials and procedures in the late 19th and early 20th century. Notably, many conservation issues arise from the interaction between iron gall inks and the paper support of manuscripts and drawings. To date, most of the research on the topic are focused on paper preservation by non-destructive analytical methods, which provide only limited information on degradation process trends and minor components, representative of iron gall ink's recipes. In the present work, three historical recipes of iron gall inks ( alizarine ink , Reid ink , modern gall ink) , dated to 19th20th century and differing for the preparation method and additives, were characterized. The molecular markers of iron gall inks and of gallic acid degradation were detected by an optimized protocol based on high performance liquid chromatography coupled to high resolution mass spectrometry (HPLC-HRMS). Furthermore, by performing ageing tests on reference materials in different indoor conditions (natural light and stored in the dark), two degradation mechanisms were observed: hydrolysis of poly-galloyl glucose species and auto-oxidation of gallic acid. Thus, different chemical profiles and ageing trends were revealed depending on the starting recipe. The procedure Limit of Detection (LOD) was estimated, improving the approaches reported so far in the literature. Finally, the strategy was successfully applied for the characterisation of the ink employed in a very degraded 16th century manuscript, granting access to the complete molecular profile of an iron gall ink with just 15 mu g of sample. (c) 2024 The Author(s). Published by Elsevier Masson SAS on behalf of Consiglio Nazionale delle Ricerche (CNR). This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

A cardiac MRI motion artifact reduction method based on edge enhancement network

Abstract: Cardiac magnetic resonance imaging (MRI) usually requires a long acquisition time. The movement of the patients during MRI acquisition will produce image artifacts. Previous studies have shown that clear MR image texture edges are of great significance for pathological diagnosis. In this paper, a motion artifact reduction method for cardiac MRI based on edge enhancement network is proposed. Firstly, the four-plane normal vector adaptive fractional differential mask is applied to extract the edge features of blurred images. The four-plane normal vector method can reduce the noise information in the edge feature maps. The adaptive fractional order is selected according to the normal mean gradient and the local Gaussian curvature entropy of the images. Secondly, the extracted edge feature maps and blurred images are input into the de-artifact network. In this network, the edge fusion feature extraction network and the edge fusion transformer network are specially designed. The former combines the edge feature maps with the fuzzy feature maps to extract the edge feature information. The latter combines the edge attention network and the fuzzy attention network, which can focus on the blurred image edges. Finally, extensive experiments show that the proposed method can obtain higher peak signal-to-noise ratio and structural similarity index measure compared to state-of-art methods. The de-artifact images have clear texture edges.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Influence of Socioeconomic Status on Functional Outcomes After Stroke: A Systematic Review and Meta-Analysis.

Abstract: BACKGROUND: This review aimed to quantify the impact of socioeconomic status on functional outcomes from stroke and identify the socioeconomic status indicators that exhibit the highest magnitude of association.METHODS AND RESULTS: We performed a systematic literature search across Medline and Embase from inception to May 2022, to identify observational studies (n≥100, and in English). Risk of bias was assessed using the modified Newcastle Ottawa Scale. Random effects meta-analysis was used to pool data. We included 19 studies (157715 patients, 47.7% women) reporting functional outcomes measured with modified Rankin Scale or Barthel index, with 10 assessed as low risk of bias. Measures of socioeconomic status reported were education (11 studies), income (8), occupation (4), health insurance status (3), and neighborhood socioeconomic deprivation (3). Pooled data suggested that low socioeconomic status was significantly associated with poor functional outcomes, including incomplete education or below high school level versus high school attainment and above (odds ratio [OR], 1.66 [95% CI, 1.40-1.95]), lowest income versus highest income (OR, 1.36 [95% CI, 1.02-1.83]), a manual job/being unemployed versus a nonmanual job/working (OR, 1.62 [95% CI, 1.29-2.02]), and living in the most disadvantaged socioeconomic neighborhood versus the least disadvantaged (OR, 1.55 [95% CI, 1.25-1.92]). Low health insurance status was also associated with an increased risk of poor functional outcomes (OR, 1.32 [95% CI, 0.95-1.84]), although this was association was not statistically significant.CONCLUSIONS: Despite great strides in stroke treatment in the past decades, social disadvantage remains a risk factor for poor functional outcome after an acute stroke. Further research is needed to better understand causal mechanisms and disparities.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Dispossessions in Bolsonaro's Brazil during the Covid-19 pandemic

Abstract: In 2020-2021 Brazil simultaneously experienced the far -right presidency of Jair Bolsonaro and the world's largest health crisis in a century. The Covid-19 pandemic struck the country deeply, killing about 690 thousand people by late 2022. They were also years of increased pressure by capital on peasants and indigenous people, targets of the violence with which capital, ever since its dawn, has wielded to advance over spaces that serve the subsistence of immediate producers. In this period, the Brazilian state continued to comply with decades-old demands from neoliberal ideology for privatizations and the dismantling of protections for workers and the poor in general. These phenomena, when articulated by theory inspired by the Marxian concept of primitive accumulation, suggest that the Bolsonaro administration and its class allies used the pandemic as a political opportunity for dispossessing policies. The article discusses this based on concepts that distinguish dispossessions that serve capital expansion from those that do not. The first group includes processes that lead to proletarianization of immediate producers in addition to the capitalization or commodification of hitherto means of subsistence. Among dispossessions that do not expand capital are those that involve the simple redistribution of surpluses or means of production. The paper contributes to the literature on dispossession by analyzing concrete manifestations of it, drawing on a conceptual framework that distinguishes dispossession types that have been conflated in much current research.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Living in the shore: changes in coastal resource intensification during the Mesolithic in northern Iberia

Abstract: Recent research on human exploitation of molluscs, echinoderms and crustaceans during the Mesolithic in the Cantabrian region (northern Iberia) has shown significant variability in the intensity of the use of coastal resources by the last hunter-fisher-gatherers throughout the similar to 4000-year expanse of the Mesolithic (10,700 - 6,700 cal BP). Previous studies have proposed hypotheses related to demographic changes to explain intensification events. In this paper we aim to unravel whether climatic and environmental changes, or other social factors, such as demography, were involved in the increase in the use of marine resources at certain times. We employed species representation, quantification and biometric analysis of the shell assemblages from the El Toral III archaeological site (Asturias, northern Iberia) to identify patterns in shell exploitation throughout the stratigraphic sequence. To establish the chronology and distinguish occupation phases of the site, we employed Bayesian modelling of radiocarbon measurements. Faunal results show that marine gastropods such as limpets of the Patella genus and topshells Phorcus lineatus (da Costa, 1778) were the most exploited species, while bivalves, echinoids and crustaceans were present in smaller quantities. The comparison of the results for El Toral III with other Mesolithic sites in the region reveals significant temporal differences in the intensity of collection of marine shell species. Results showed that intensification processes are not clearly related to climate change but to other social factors, such as demography, suggesting that intensification and relaxation in shell collection events were strategies adopted depending on the needs of the human groups at different times.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Livestock management during times of transition. Exploring the relationship between animal size and diet from Roman to early medieval Augusta Raurica (Switzerland)

Abstract: Zooarchaeological research all over Europe has suggested a generalised pattern of livestock size decrease during the transition between the Roman times and the Early Middle Ages. Different reasons have been proposed to explain this pattern, including a change in management and feeding practices, in the context of a shift of animal husbandry from large to small scale production. This paper is based on faunal material from Roman and early medieval Augusta Raurica, north-western Switzerland, and provides a first attempt to test this hypothesis, by combining zooarchaeological information (taxonomic frequencies and biometrical analysis) and stable carbon and nitrogen isotope data from bone collagen of cattle and pig. The results suggest important changes in livestock management, such as a shift towards pig husbandry, and evidence for increased use of pannage and forest pastures has been found.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

The pavement layers of the Southwest Church of Umm el-Jimal, Jordan: stratigraphy and archaeometric characterization

Abstract: The article focuses on the stratigraphy of the late Byzantine pavement of the Southwest Church, Umm el-Jimal, Jordan and the production technology of their mortars by applying thin section petrography, x-ray diffractometry (XRD) and scanning electron microscopy with energy dispersive x-ray spectrometry (SEM-EDS). Investigations revealed the similarity between the studied pavement and standard Roman mosaic pavements. The pavement consists of four layers (statumen, rudus, nucleus and bedding), but lacks the tessellatum layer. The statumen was constructed using large stones and then leveled by soil and pebbles, while the other three layers are composed of lime-based mortars formed by two different recipes. The white-beige non-hydraulic mortar of the bedding layer consists of a lime binder and aggregates of scoria and organic fibers, and a Binder:Aggregate (B:A) ratio of 1:2. The grey hydraulic mortars of the rudus and nucleus are mixtures of lime and silica-rich silt/clay, fine sand, volcanic rocks, ceramics, and charcoal; and B:A ratios of 1:4. The rudus and nucleus mortars have high values of hydraulic and cementation indices, reflecting their hydraulic properties, which most probably originated from the reaction between lime, ceramic and volcanic inclusions. In contrast, lack of ceramic and absence of the reactions between lime and scoria of the bedding layer probably produced a mortar with low values of hydraulic and cementation indices, but durable and resistant to weight load.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Retrieving images from tarnished daguerreotypes using X-ray fluorescence imaging with an X-ray micro beam with tunable energy

Abstract: We report recent observations using a synchrotron X-ray micro-beam to retrieve images from tarnished 19th century daguerreotypes. We confirm that high quality image can always be retrieved from tarnished plates using Hg L alpha XRF as long as the bulk of the image particles and their distribution remains intact. We also report results from using tunable tender X-rays (2 - 7 keV) to conduct imaging in high vacuum at energy above the Ag L-edge and the Hg M-edge, extracting images using Ag L alpha and Hg M alpha, respectively among others (e.g., S to track corrosion). Images obtained with the surface sensitive total electron yield (TEY) and the bulk sensitive fluorescence yield (FLY) as well as corresponding micro-XANES are reported. Flux tolerance to high intensity X-beam is also explored. These results and their implications for cultural heritage research are discussed. (c) 2024 The Authors. Published by Elsevier Masson SAS on behalf of Consiglio Nazionale delle Ricerche (CNR). This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Fuzzy machine learning logic utilization on hormonal imbalance dataset.

Abstract: In this research work, a novel fuzzy data transformation technique has been proposed and applied to the hormonal imbalance dataset. Hormonal imbalance is ubiquitously found principally in females of reproductive age which ultimately leads to numerous related medical conditions. Polycystic Ovary Syndrome (PCOS) is one of them. Treatment along with adopting a healthy lifestyle is advised to mitigate its consequences on the quality of life. The biological dataset of hormonal imbalance PCOS provides limited results that is whether the syndrome is present or not. Also, there are input variables that contain binary responses only, to deal with this conundrum, a novel fuzzy data transformation technique has been developed and applied to them thus leading to their fuzzy transformation which provides a broader spectrum to diagnose PCOS. Due to this, the output variable has also been transformed. Hence, a novel fuzzy transformation technique has been employed due to the limitation of the dataset leading to the transition of binary classification output into three classes. An adaptive fuzzy machine learning logic model is developed in which the inference of the transformed biological dataset is performed by the machine learning techniques that provide the fuzzy output. Machine learning techniques have also been applied to the untransformed biological dataset. Both implementations have been compared by computation of the relevant metrics. Machine learning employment on untransformed biological dataset provides limited results whether the syndrome is present or absent however machine learning on fuzzy transformed biological dataset provides a broader spectrum of diagnosis consisting of a third class depicting that PCOS might be present which would ultimately alert a patient to take preventive measures to minimize the chances of syndrome development in future.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Structural Plan Schema Generation Through Generative Adversarial Networks

Abstract: This paper suggests a workflow that generates floor plans with structural elements. Generating structural layouts in a BIM environment with the implementation of a machine learning method allows a future projection for fast and easy exploration of multiple design options. Pix2Pix, a Generative Adversarial Networks (GAN) model, takes the wall layout as input and generates a structural layout by learning from existing knowledge used to generate a decision support system for structural layout generation. The paper also suggest an additional script as a fine-adjustment model to refine the structural layout based on predetermined structural rules. This script increases the accuracy of the structural layouts generated by the GAN algorithm. Based on the test dataset, the research demonstrates a 64% success rate in providing structural schema assistance. Considering the results, this study seems to have the potential to be a supportive application in the early design phase.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Variational propensities: development and ultimate causes

Abstract: This paper applies philosophical tools from the causalists/statisticalists debate to the evo-devo idea of variational tendencies as propensities biasing phenotypic change. It contends that variational properties are present in a statistical sense in some population dynamics models, particularly quantitative genetics ones, providing ultimate variational explanations. It further argues that these properties, contrary to some recent views, cannot be subsumed under natural selection. Finally, it advocates for a causalist interpretation of these explanations, where variational statistical properties indirectly refer to evo-devo's variational propensities.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Brief Educational Workshops in Secondary Schools Trial (BESST trial), a school-based cluster randomised controlled trial of the DISCOVER workshop for 16-18-year-olds: recruitment and baseline characteristics.

Abstract: BACKGROUND: The Brief Educational Workshops in Secondary Schools Trial (BESST) is an England-wide school-based cluster randomised controlled trial assessing the clinical and cost-effectiveness of an open-access psychological workshop programme (DISCOVER) for 16-18-year-olds. This baseline paper describes the self-referral and other recruitment processes used in this study and the baseline characteristics of the enrolled schools and participants.METHOD: We enrolled 900 participants from 57 Secondary schools across England from 4th October 2021 to 10th November 2022. Schools were randomised to receive either the DISCOVER day-long Stress workshop or treatment as usual which included signposting information. Participants will be followed up for 6months with outcome data collection at baseline, 3-month, and 6-month post randomisation.RESULTS: Schools were recruited from a geographically and ethnically diverse sample across England. To reduce stigma, students were invited to self-refer into the study if they wanted help for stress. Their mean age was 17.2 (SD=0.6), 641 (71%) were female and 411 (45.6%) were from ethnic minority groups. The general wellbeing of our sample measured using the Mood and Feelings Questionnaire (MFQ) found 314 (35%) of students exhibited symptoms of depression at baseline. Eighty percent of students reported low wellbeing on the Warwick Edinburgh Mental Wellbeing Scale (WEMWBS) suggesting that although the overall sample mean is below the cut-off for depression, the self-referral approach used in this study supports distressed students in coming forward.CONCLUSION: The BESST study will continue to follow up participants to collect outcome data and results will be analysed once all the data have been collected.TRIAL REGISTRATION: ISRCTN registry ISRCTN90912799. Registered on 28 May 2020.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Structure and age of ancient walls from the city of Nan, northern Thailand

Abstract: The structure and age of remains of two ancient walls located in the city of Nan, a former part of the Lanna Kingdom in modern northern Thailand, were investigated. The remains differ in appearance with a well-preserved brick wall present at Mahawong Road (MHW), while an earthwork with a brick reinforcement core is found at Phaya Wat Temple (PWT). We employed an electrical resistivity tomography (ERT) survey and optically stimulated luminescence dating (OSL) to determine the buried structure of the earthwork at the PWT site and the production age of bricks from both locations. The ERT results reveal lateral heterogeneous resistivity domains cross-cutting the wall, which presumably relates to the construction of a dam. According to OSL dating, the PWT wall was likely built during the time of the war with Burma that ultimately resulted in a foreign occupation of Nan in the sixteenth century. This structure played a role in both flood mitigation and military defence of the city. The structure at MHW represents a city wall that was built at the end of the nineteenth century after Nan was relocated to its present position and rather reflects representative and social needs.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

The effect of retirement on physical and mental health in China: a nonparametric fuzzy regression discontinuity study.

Abstract: BACKGROUND: With the rapid aging of the domestic population, China has a strong incentive to increase the statutory retirement age. How retirement affects the health of the elderly is crucial to this policymaking. The health consequences of retirement have been debated greatly. This study aims to investigate the effects of retirement on physical and mental health among Chinese elderly people.METHODS: The data we use in this study comes from four waves (2011, 2013, 2015, and 2018) of the Harmonized China Health and Retirement Longitudinal Study (Harmonized CHARLS), a prospective cohort. We use the nonparametric fuzzy regression discontinuity design to estimate the effects of retirement on physical and mental health. We test the robustness of our results with respect to different bandwidths, kernel functions, and polynomial orders. We also explore the heterogeneity across gender and education.RESULTS: Results show that retirement has an insignificant effect on a series of physical and mental health outcomes, with and without adjusting several sociodemographic variables. Heterogeneity exists regarding gender and education. Although stratified analyses indicate that the transition from working to retirement leaves minimal effects on males and females, the effects go in the opposite direction. This finding holds for low-educated and high-educated groups for health outcomes including depression and cognitive function. Most of the results are stable with respect to different bandwidths, kernel functions, and polynomial orders.CONCLUSIONS: Our results suggest that it is possible to delay the statutory retirement age in China as retirement has insignificant effects on physical and mental health. However, further research is needed to assess the long-term effect of retirement on health.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

The intersection of diet, class, and sex during the Eastern Zhou (770-221 BCE): Bioarchaeological evidence from the Dahan cemetery, China

Abstract: The Eastern Zhou (770-221 BCE) was an important period of social transformation in ancient China. The development of class- and gender-based stratification of this period had profound effects on human diet. We aim to examine the relationships among diet, class, and sex (as a proxy for gender) during this period through comparative investigations of noble individuals and sacrificial human companions. We analyzed the stable carbon and nitrogen isotope values of bone collagen of 61 human (26 nobles and 35 sacrificial companions) and 32 faunal samples from the Dahan (sic) cemetery (an Eastern Zhou archaeological site). There are statistically significant class-based dietary differences, with the nobles consuming more socially valued foods (high protein food and millets) compared with sacrificial companions, which is also supported by paleopathological evidence. Sex-based differences were specific to class, with no significant dietary differences found in the nobles, whereas males may have had better diets than females in the lower classes. Our dietary analysis suggests that some sacrificial companions may have benefited from the resources of their noble masters, however, most sacrificial companions had a poorer diet. In addition, one noble individual possibly experienced social mobility in his lifetime, as shown by the discrepancy in his burial treatment and his long-term diet. This cemetery-wide study of dietary differences between nobles and sacrificial companions allows for novel insight into the intersection of class, gender, and diet during the Eastern Zhou period.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Prediction of reverse osmosis membrane fouling in water reuse by integrated adsorption and data-driven models

Abstract: In contemporary society, the reverse osmosis (RO) process is important for water treatment and reuse industry. However, membrane fouling remains a challenging issue during operation. To date, RO system operation mainly relies on the operator's knowledge, and the maintenance is carried out based on schedule or pre-defined criteria due to our limited understanding of RO fouling in real applications. To better understand the process and enable system optimization, an integrated data-driven coupled with adsorption model has been proposed in this study. The data-driven model calibrates the mechanistic model and predicts future values, while the adsorption model provides predictions on transmembrane pressure (TMP). By integrating these two models, an accurate prediction with high robustness and an insight into the detailed fouling mechanisms in real plants were achieved. In addition to the model itself, multiple regression analysis (MRA) had also been applied to identify the dominant fouling mechanisms. This analysis confirms that it is highly possible that membrane fouling is developed from an intermediate pore blockage to cake filtration.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

Virtual agri-food supply chains: A holistic digital twin for sustainable food ecosystem design, control and transparency

Abstract: The transition of Agri-Food Supply Chains (AFSC) toward sustainable patterns able to secure safe, quality, and affordable food whilst preserving natural and anthropogenic ecosystems is a key challenge of this century. Increasing production and distribution operations' transparency and impact visibility uncovers hidden complexities and the food ecosystem's externalities. To this attempt, this paper introduces a novel Agri-Food Supply Chain digital twin (AFSC-DT) able to virtualize the agricultural, processing, warehousing, and distribution operations holistically from-field-to-consumer and estimate economic, logistic, environmental, safety, and nutritional indicators associated with any food order, assumed as the functional unit. The AFSC-DT behaves as a control tower, providing a multi-dimensional dashboard of indicators and labels to enhance practitioners' and consumers' knowledge of FSC entities and operations. The practitioner's visibility drives top-down operational and tactical feedback controls through real-time monitoring and a-posteriori multi-dimensional performance analysis, whilst consumers, with their informed choices, perform a strategic bottom-up pressure on the food industry toward a sustainable redesign. A what-if simulation analysis conducted over four virtual scenarios within a regional horticultural AFSC proves how the AFSC-DT aids informed decision-making across the AFSC echelons, stimulating a virtuous cycle and favoring a progressive transition toward more sustainable patterns.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.

The Analysis of Physical Performance During Official Competitions in Professional English Football: Do Positions, Game Locations, and Results Influence Players' Game Demands?

Abstract: ABSTRACT: Beato, M, Youngs, A, and Costin, AJ. The analysis of physical performance during official competitions in professional English football: Do positions, game locations, and results influence players' game demands? J Strength Cond Res 38(5): e226-e234, 2024-This study aimed, first, to verify if physical parameters were different between players' positions during official matches in English professional football, and second, if the game location (H and A) or results (W, L, D) affected players' physical performance. Twenty-five male professional football players of the same team were included in this data analysis (age = 27 ± 9 years) during the 2022-23 season. Players were divided into positions: center backs, wide backs, center midfielders, attacking midfielders, and strikers. The external load parameters were distance covered, high-speed running (HSR), sprinting distance, accelerations, decelerations, and high metabolic load distance (HMLD, meters > 25.5 w·kg -1 ) that were monitored using global navigation satellite systems Apex (STATSports). Linear mixed models' analysis for positions reported a significant difference in total distance ( p = 0.011), HSR ( p < 0.001), sprinting distance ( p < 0.001), accelerations ( p = 0.003), decelerations ( p = 0.002), and HMLD ( p < 0.001). Centre backs showed the lowest physical performance in the metrics analyzed, whereas players in the other positions frequently displayed a similar physical performance. Regarding locations and results, differences were only found between locations for decelerations ( p = 0.041) and between results for HMLD ( p = 0.010). In conclusion, physical performance was influenced by players' positions, whereas game location or results seem to not affect physical performance during official competitions. Consequently, practitioners can physically prepare their players independently from the location of the match or of the possible game results, whereas specific positional training is requested to optimally prepare their players.

Based on the text of the abstract in the field of humanities and social sciences given below, give the most likely title, and output only the title and nothing else.