bigbio/gad · Datasets at Hugging Face

id stringlengths 1 4	document_id stringlengths 1 4	text stringlengths 42 538	labels list
900	900	it is unlikely that common variants in MLH1, MLH3, PMS1, MSH2, MSH3 and @GENE$ contribute significantly to @DISEASE$ susceptibility.	[ "1" ]
901	901	An original finding is the increased risk of @DISEASE$ and recurrence of pregnancy negative events, probably by modulating the maternal-fetal flow, in women homozygous for the eNOS 894T allele previously analyzed for the @GENE$ I/D polymorphism.	[ "1" ]
902	902	In conclusion, this study shows that Korean with specific polymorphism in @GENE$ are neither more susceptible to develop cervical cancer nor more vulnerable for @DISEASE$.	[ "0" ]
903	903	No association between the @GENE$ -94 @DISEASE$/delATTG promoter polymorphism or with other NF-kappaB complex SNP in patients with PsA from Newfoundland was observed.	[ "0" ]
904	904	@GENE$ is not likely to be a major susceptibility gene for @DISEASE$ in this Korean population.	[ "1" ]
905	905	We conclude that multiple haplotypes on the @GENE$ gene seem to confer a risk for developing @DISEASE$ in Caucasians.	[ "1" ]
906	906	Polymorphisms in the GPX-1 and @GENE$ genes are associated with an increased risk of @DISEASE$.	[ "1" ]
907	907	Since the SH2D2A protein modulates T cell activation, this may be a mechanism for how short @GENE$ alleles confer susceptibility to develop @DISEASE$.	[ "1" ]
908	908	This study suggests a positive association between synapsin II and @DISEASE$, implying that @GENE$ is involved in the etiology of schizophrenia.	[ "1" ]
909	909	@GENE$ and PVRL2 have little or no effect on the clinical outcome of @DISEASE$.	[ "1" ]
910	910	This study therefore suggest no major modifying role for the @GENE$ polymorphism in development of asbestos-associated @DISEASE$.	[ "0" ]
911	911	(1) DRB1 * 0405 and DRB1 * 15 are closely associated with the susceptibility to VKH syndrome, DRB1 * 0405 may be the major susceptible gene and DRB1 * 15 may be the minor; (2) DRB1 * 14 and DRB1 * 08 are negatively associated with the susceptibility to @DISEASE$, suggesting that they may be the resistant genes; (3) @GENE$ * 0405 is not related to the clinical features, incidence of ocular complications as well as visual prognosis.	[ "1" ]
912	912	We conclude that variations in the nine ectodomains of @GENE$ do not increase susceptibility to @DISEASE$.	[ "1" ]
913	913	The results suggest that variation in @GENE$ affects risk of @DISEASE$ in the mestizo population of central Mexico (Mexico City and Orizaba) and in Mexican Americans (Starr County, Texas).	[ "1" ]
914	914	We conclude that @GENE$ through its K-variant, rather than a nearby marker, is a susceptibility factor for @DISEASE$ and enhances the AD risk defined by APOE epsilon4 alone in an age-dependent manner.	[ "0" ]
915	915	Our study finds no evidence for association of the @GENE$ SNP309 polymorphism with clinicopathologic variables, recurrence risk, and overall survival outcome in @DISEASE$.	[ "1" ]
916	916	Considering the relatively low frequency of haplotype 221 and that none of the haplotypes including 221 was associated with any of the @DISEASE$-related quantitative @GENE$ tested, it is concluded that SNP-43, -56, and -63 of the CAPN10 gene variants may play a limited role in the risk of type 2 diabetes risks in this cohort of West Africans.	[ "0" ]
917	917	The hybridization @GENE$ genotype at the site of 2257 in EXON2 of insulin-receptor gene might have a candidate gene to serve as a protective factor for @DISEASE$.	[ "0" ]
918	918	Although the polymorphism of @GENE$ gene G894T did not seem to play an important and direct role in the @DISEASE$ of EH it might have indirect effects through certain risk factors.	[ "0" ]
919	919	These results suggest that polymorphisms of the @GENE$ gene, but not the ACE gene, may be associated with the development of @DISEASE$.	[ "1" ]
920	920	Although linkage disequilibrium with other genetic alterations cannot be excluded, the @GENE$ core promoter variants, found in this study, may contribute to a common pathophysiologic feature of @DISEASE$.	[ "1" ]
921	921	The @GENE$ Thr92Ala variant does not confer an increased risk of T2D, @DISEASE$, or insulin resistance.	[ "0" ]
922	922	These findings suggest that the presence of the variant allele in the promoter of MMP2 or @GENE$ may be a protective factor for the development of @DISEASE$.	[ "1" ]
923	923	In conclusion, the @GENE$ blood group B allele was found to be an independent risk factor for @DISEASE$.	[ "1" ]
924	924	The C allele in the @GENE$ gene might be associated with the susceptibility to CAD and potentially plays an important role in the manifestation of @DISEASE$ among Chinese.	[ "1" ]
925	925	Despite the limited study sample, our data suggest that @GENE$ mutations might be present less frequently than KRAS mutations in Greek patients with @DISEASE$.	[ "0" ]
926	926	These results support the hypothesis that the African-American population is an older population compared with the other samples and the two @GENE$ receptors may play a role in @DISEASE$ pressure regulation.	[ "0" ]
927	927	Our results do not provide evidence for a strong involvement of @GENE$ in the development of AGA, although a @DISEASE$ role cannot be fully excluded.	[ "0" ]
928	928	These data suggest that the @GENE$ allele is more frequent in brain @DISEASE$ associated with large-vessel occlusion.	[ "0" ]
929	929	Neither @GENE$ I/D nor CYP11B2 -344C/T polymorphisms were useful to predict left ventricular mass, function or @DISEASE$ in our hypertensive patients with normal coronary arteries.	[ "0" ]
930	930	Our findings are consistent with the notion that genetic variation in the @GENE$ neurotransmitter system contributes to the @DISEASE$ of panic disorder.	[ "0" ]
931	931	These results indicate a possible association between the @GENE$ allele and an overexpression of noncognitive @DISEASE$ in AD.	[ "0" ]
932	932	Overtransmission of particular haplotypes of @GENE$, that may relate to the expression level of NrCAM in the brain, appeared to be associated with @DISEASE$ in the severe obsessive-compulsive behavior subset.	[ "0" ]
933	933	Our investigation suggests that the two promoter SNPs are unrelated to the development of @DISEASE$, however, further investigation at the promoter region of @GENE$ may be necessary to address its potential implication of gene expression in AD.	[ "1" ]
934	934	TT genotype of @GENE$-1055 is not an independent factor for COPD in Chinese Han people in Beijing, but increases the risk for smokers to develop @DISEASE$ and the one who has COPD family history as well.	[ "1" ]
935	935	We conclude from our data that @GENE$ does not play a major role in the development of @DISEASE$ in our Caucasian population.	[ "1" ]
936	936	The present study provides further evidence in support of the @GENE$ association with @DISEASE$ in Chinese population.	[ "1" ]
937	937	These observations suggest that lower expression of @GENE$ decreases the risk of @DISEASE$ by reducing the excretion of 2-hydroxyestradiol, the antiproliferative metabolite of E(2), in the endometrium.	[ "1" ]
938	938	This @DISEASE$ supports our hypothesis that a dominant gene within the @GENE$ region (marked by HSP70-1 and HSP70-2), but not necessarily HLA, is associated with CA in two different ethnic groups.	[ "0" ]
939	939	The present data indicate that mutations of @GENE$ may cause non-syndromic hearing @DISEASE$.	[ "0" ]
940	940	Although some molecular variants within the SLC3A1 gene were associated with clinical traits in @DISEASE$ patients, the low detection rate of mutations in this gene strongly suggests that variation of the @GENE$ is not the major genetic factor contributing to cystinuria in this Mediterranean population.	[ "1" ]
941	941	@GENE$ therapy reduces increased stent @DISEASE$ rates and improves clinical outcome following coronary stent implantation in patients bearing the Pl(A2)allele, suggesting that statins interfere with the functional consequence of a genetically determined platelet-mediated risk factor associated with Pl(A2)polymorphism.	[ "0" ]
942	942	C311S polymorphism of @GENE$ has no significant correlation with stroke in Han people of Chinese Hunan area and allele C/S is not an independent risk factor for @DISEASE$,neither is G148A.	[ "1" ]
943	943	In conclusion, a significant association between @DISEASE$ and @GENE$ T51C polymorphism localized on chromosome 3p21 was found.	[ "1" ]
944	944	These data suggest that there is a significant association between the genetic polymorphisms of @GENE$, p21, and specific combinations of the at-risk genotypes of these genes and the risk of developing @DISEASE$ in Korean women.	[ "1" ]
945	945	These results, in accordance with similar findings previously obtained in other ethnic groups, suggest that these two @GENE$ allelic variants may not have a direct role in the @DISEASE$ and development of obesity.	[ "0" ]
946	946	The SNP021 in the gene SCN7A is associated with essential hypertension of Chinese Han population in Shanghai and the role of @GENE$ gene in @DISEASE$ deserves to be further analyzed.	[ "1" ]
947	947	Our findings suggest that the (CCTTT)(n) repeat polymorphism in the promoter of the @GENE$ gene that affects promoter activity is a risk factor for the development of @DISEASE$, and this genetic effect seems independent of asthma.	[ "1" ]
948	948	These results indicate that polymorphisms in the @GENE$ gene are associated with NTG and may be a marker for the @DISEASE$.	[ "0" ]
949	949	These results suggest that in men, the human @GENE$ gene is associated with reduced amount of @DISEASE$ and lower insulin secretory responses to a glucose load.	[ "0" ]
950	950	Our data indicate polymorphism in intron 4 of the @GENE$ gene affects the occurrence of APA and may slightly modify the risk of sporadic @DISEASE$.	[ "1" ]
951	951	The @GENE$-V/F158 polymorphism has a significant impact on the development of @DISEASE$.	[ "0" ]
952	952	These findings suggest that the investigated @GENE$ genetic polymorphism does not play a major role in the pathogenesis of @DISEASE$.	[ "1" ]
953	953	These findings provide initial evidence that environmental risks as described by the Rutter Family Adversity Index moderate the impact of the @GENE$ gene on @DISEASE$ symptoms, suggesting a DAT1 effect only in those individuals exposed to psychosocial adversity.	[ "1" ]
954	954	Our findings suggest that these common @GENE$ polymorphisms do not play a major role in susceptibility to @DISEASE$ or type 2 diabetes in this population.	[ "0" ]
955	955	After correction for multiple comparisons, the addition of genetic information observed in the present study had little @GENE$ on risk prediction models for @DISEASE$.	[ "0" ]
956	956	The @GENE$ promoter SNP309 is associated with the presence of @DISEASE$ in Chinese patients especially those with H.	[ "0" ]
957	957	The polymorphism that confers susceptibility to @GENE$ II (@DISEASE$ in some populations is associated in United Kingdom Caucasians with enhanced microvascular function in the presence of normoglycaemia.	[ "0" ]
958	958	Our data suggest that neither the +36 TNFRSF1A SNP nor the +196 @GENE$ SNP is associated with @DISEASE$ severity in a population of Caucasian patients with RA.	[ "1" ]
959	959	These results suggested that the CTLA-4 gene might be involved in the susceptibility to @DISEASE$ in the Chinese Han population and both +49 and CT60 of @GENE$ gene might be the causal variants in RA disease.	[ "1" ]
960	960	We conclude, therefore, that the @GENE$-bp @DISEASE$ of the AIRE1 gene is not a susceptibility locus for the more common autoimmune endocrinopathies in the United Kingdom.	[ "0" ]
961	961	Our results show that the C1773 @DISEASE$ of @GENE$ increases susceptibility to hypertension, but not via hypercholesterolaemia.	[ "0" ]
962	962	Neither the @GENE$ K121Q nor the GLUT-1 XbaI polymorphism contribute to the genetic susceptibility of diabetic microvascular @DISEASE$ in Danish type 1 diabetic patients.	[ "0" ]
963	963	this large-scale evaluation of candidate @DISEASE$ genes has identified common genetic variants in the regulatory regions of @GENE$ that could be associated with bladder cancer risk.	[ "0" ]
964	964	These data suggest that there is a significant association between the genetic polymorphisms of p53, @GENE$, and specific combinations of the at-risk genotypes of these genes and the risk of developing @DISEASE$ in Korean women.	[ "0" ]
965	965	An original @DISEASE$ is the increased risk of pre-eclampsia and recurrence of pregnancy negative events, probably by modulating the maternal-fetal flow, in women homozygous for the @GENE$ 894T allele previously analyzed for the ACE I/D polymorphism.	[ "0" ]
966	966	These results indicate that the @GENE$ variant haplotype is functionally significant in patients with @DISEASE$, being associated with increased nuclear translocation of NF-kappaB, more severe organ dysfunction, and higher mortality.	[ "1" ]
967	967	None of the SNPs of KCNQ1 P448R, KCNQ1 R519H, KCNQ1 G643S, KCNE1 G38S and @GENE$ D85N was associated with @DISEASE$ phenotype, but KCNE4 E145D may relation to atrial fibrillation.	[ "1" ]
968	968	In conclusion, TSER genotype is not an efficacious marker for @DISEASE$ sensitivity to 5-@GENE$-based oral adjuvant chemotherapy for Japanese colorectal cancer patients after curative resection.	[ "0" ]
969	969	These results indicated that @GENE$ polymorphisms may be associated with the level of blood IGFBP-3 protein and an increased risk of @DISEASE$.	[ "1" ]
970	970	Our data support the hypothesis that the @GENE$ locus may be a significant genetic determinant for @DISEASE$ risk in whites and that women are more sensitive to the genetic effects of perilipin than men.	[ "1" ]
971	971	Mutations in the @GENE$ gene are unlikely to be directly causative of @DISEASE$.	[ "1" ]
972	972	@DISEASE$, serum folate levels and both C677T and A1298C @GENE$ mutations are associated with CVD in HD patients.	[ "0" ]
973	973	@GENE$ activation is present in healthy subjects at risk of developing @DISEASE$ as well as in established type 2 diabetic patients, and it is associated with impairments in the vascular reactivity in the skin microcirculation.	[ "0" ]
974	974	The investigated @GENE$ and 5-@DISEASE$-2A gene variants, therefore, do not seem to play a major role in SSRI antidepressant activity.	[ "0" ]
975	975	Based on these data, @GENE$ is not the causative gene for @DISEASE$.	[ "1" ]
976	976	This study suggests that possession of the @GENE$ allele with higher levels of IFN-alpha significantly increases the risk of @DISEASE$.	[ "0" ]
977	977	None of the SNPs of KCNQ1 P448R, KCNQ1 R519H, KCNQ1 G643S, KCNE1 G38S and @GENE$ D85N was associated with atrial fibrillation phenotype, but KCNE4 E145D may relation to @DISEASE$.	[ "1" ]
978	978	We conclude that IL-4-589T, but not TNF-alpha-3082 or Fcalpha RIbeta*G, is a risk factor for the development of @GENE$, @DISEASE$, and rhinitis by 12 mo of age.	[ "1" ]
979	979	These data provide no evidence that heteroallelic mutations or polymorphisms in the @GENE$ are involved in the development of @DISEASE$ early-onset MG but raise issues for future studies.	[ "0" ]
980	980	FAS and @GENE$ polymorphisms appear to jointly contribute to risk of @DISEASE$ in this southern Chinese population.	[ "1" ]
981	981	The areas of atherosclerotic lesions in @GENE$ appear to be dependent on the amount of alcohol @DISEASE$, especially in men carrying the PON1 M55 allele.	[ "0" ]
982	982	The present findings indicated that certain alleles or genotypes of the CNR1 gene may confer a susceptibility of @DISEASE$, especially of the hebephrenic @GENE$.	[ "0" ]
983	983	Consequently, the @DISEASE$ suggests that the @GENE$ polymorphism was not associated with the risk of myeloid leukemia.	[ "0" ]
984	984	Our results show that the 4G/4G PAI-1 genotype appears to be associated with an elevated relative risk of developing @DISEASE$, regardless of @GENE$ levels and other hypertension-related factors, in a representative sample of the Spanish population.	[ "1" ]
985	985	The @GENE$ variant at position -308 in the promoter region of the TNFalpha gene does not influence the amount of weight lost in @DISEASE$ and obese men and women on a 30% energy restricted diet.	[ "0" ]
986	986	the 660L allele may be associated with a moderately increased risk of breast cancer, but that other common SNPs in the @GENE$ gene are unlikely to be associated with a substantial risk of @DISEASE$.	[ "1" ]
987	987	These findings suggest that a variant in @GENE$ is not only important in the development of @DISEASE$ but also in disease progression, possibly related to enhanced airway remodelling.	[ "1" ]
988	988	Our results suggest @GENE$ and TIMP-2 genotypes play a crucial role in @DISEASE$ invasion, but not with development of gastric cancer.	[ "1" ]
989	989	These results show no evidence of an association between the @GENE$-uVNTR polymorphism and completed suicides and suggest that MAOA is not involved in the susceptibility to @DISEASE$.	[ "1" ]
990	990	These findings suggest that individual susceptibility of @DISEASE$ may be modulated by @GENE$ and MnSOD polymorphisms, and that the combination of genetic factors involved in oxidative stress response with environmental carcinogens may play an important role in bladder carcinogenesis.	[ "1" ]
991	991	These data suggest that this polymorphism of the @GENE$ gene is not associated with GD in the UK and is therefore not contributing to @DISEASE$ susceptibility in the chromosomal region designated GD-2.	[ "0" ]
992	992	Our results suggest that the @GENE$ Val511Ala SNP does not antagonize the effect of NSAIDs on colon cancer risk and provides support that NSAID use and the COX-2 Val511Ala SNP may contribute to a reduced risk of @DISEASE$ among African Americans.	[ "1" ]
993	993	Together, our findings suggest that the presence of @GENE$ gene polymorphisms may be inconclusive in the susceptibility to @DISEASE$ or in the clinical characteristics of Japanese patients with MS and, therefore, need further studies.	[ "1" ]
994	994	These results suggest that variation of @GENE$ may be an important determinant of @DISEASE$, in part through the mechanism of accelerated postmenopausal bone loss.	[ "0" ]
995	995	We conclude that @GENE$ (-174) polymorphism does not influence the risk of developing @DISEASE$ in our cohort.	[ "1" ]
996	996	Our results indicate for the first time that low numbers of @GENE$) PNTR and plasma Lp(a) levels are independently associated with both ischemic and @DISEASE$ in Chinese.	[ "0" ]
997	997	In conclusion, differences in estrogen levels due to polymorphism at the @GENE$ CYP19 gene may predispose men to increased @DISEASE$ and fracture risk.	[ "0" ]
998	998	(1) @GENE$ * 0405 and DRB1 * 15 are closely associated with the susceptibility to VKH syndrome, DRB1 * 0405 may be the major susceptible gene and DRB1 * 15 may be the minor; (2) DRB1 * 14 and DRB1 * 08 are negatively associated with the susceptibility to @DISEASE$, suggesting that they may be the resistant genes; (3) DRB1 * 0405 is not related to the clinical features, incidence of ocular complications as well as visual prognosis.	[ "1" ]
999	999	These two @GENE$ gene mutations may account for a substantial fraction of hereditary @DISEASE$.	[ "1" ]

900

it is unlikely that common variants in MLH1, MLH3, PMS1, MSH2, MSH3 and @GENE$ contribute significantly to @DISEASE$ susceptibility.

[ "1" ]

901

An original finding is the increased risk of @DISEASE$ and recurrence of pregnancy negative events, probably by modulating the maternal-fetal flow, in women homozygous for the eNOS 894T allele previously analyzed for the @GENE$ I/D polymorphism.

[ "1" ]

902

In conclusion, this study shows that Korean with specific polymorphism in @GENE$ are neither more susceptible to develop cervical cancer nor more vulnerable for @DISEASE$.

[ "0" ]

903

No association between the @GENE$ -94 @DISEASE$/delATTG promoter polymorphism or with other NF-kappaB complex SNP in patients with PsA from Newfoundland was observed.

[ "0" ]

904

@GENE$ is not likely to be a major susceptibility gene for @DISEASE$ in this Korean population.

[ "1" ]

905

We conclude that multiple haplotypes on the @GENE$ gene seem to confer a risk for developing @DISEASE$ in Caucasians.

[ "1" ]

906

Polymorphisms in the GPX-1 and @GENE$ genes are associated with an increased risk of @DISEASE$.

[ "1" ]

907

Since the SH2D2A protein modulates T cell activation, this may be a mechanism for how short @GENE$ alleles confer susceptibility to develop @DISEASE$.

[ "1" ]

908

This study suggests a positive association between synapsin II and @DISEASE$, implying that @GENE$ is involved in the etiology of schizophrenia.

[ "1" ]

909

@GENE$ and PVRL2 have little or no effect on the clinical outcome of @DISEASE$.

[ "1" ]

910

This study therefore suggest no major modifying role for the @GENE$ polymorphism in development of asbestos-associated @DISEASE$.

[ "0" ]

911

(1) DRB1 * 0405 and DRB1 * 15 are closely associated with the susceptibility to VKH syndrome, DRB1 * 0405 may be the major susceptible gene and DRB1 * 15 may be the minor; (2) DRB1 * 14 and DRB1 * 08 are negatively associated with the susceptibility to @DISEASE$, suggesting that they may be the resistant genes; (3) @GENE$ * 0405 is not related to the clinical features, incidence of ocular complications as well as visual prognosis.

[ "1" ]

912

We conclude that variations in the nine ectodomains of @GENE$ do not increase susceptibility to @DISEASE$.

[ "1" ]

913

The results suggest that variation in @GENE$ affects risk of @DISEASE$ in the mestizo population of central Mexico (Mexico City and Orizaba) and in Mexican Americans (Starr County, Texas).

[ "1" ]

914

We conclude that @GENE$ through its K-variant, rather than a nearby marker, is a susceptibility factor for @DISEASE$ and enhances the AD risk defined by APOE epsilon4 alone in an age-dependent manner.

[ "0" ]

915

Our study finds no evidence for association of the @GENE$ SNP309 polymorphism with clinicopathologic variables, recurrence risk, and overall survival outcome in @DISEASE$.

[ "1" ]

916

Considering the relatively low frequency of haplotype 221 and that none of the haplotypes including 221 was associated with any of the @DISEASE$-related quantitative @GENE$ tested, it is concluded that SNP-43, -56, and -63 of the CAPN10 gene variants may play a limited role in the risk of type 2 diabetes risks in this cohort of West Africans.

[ "0" ]

917

The hybridization @GENE$ genotype at the site of 2257 in EXON2 of insulin-receptor gene might have a candidate gene to serve as a protective factor for @DISEASE$.

[ "0" ]

918

Although the polymorphism of @GENE$ gene G894T did not seem to play an important and direct role in the @DISEASE$ of EH it might have indirect effects through certain risk factors.

[ "0" ]

919

These results suggest that polymorphisms of the @GENE$ gene, but not the ACE gene, may be associated with the development of @DISEASE$.

[ "1" ]

920

Although linkage disequilibrium with other genetic alterations cannot be excluded, the @GENE$ core promoter variants, found in this study, may contribute to a common pathophysiologic feature of @DISEASE$.

[ "1" ]

921

The @GENE$ Thr92Ala variant does not confer an increased risk of T2D, @DISEASE$, or insulin resistance.

[ "0" ]

922

These findings suggest that the presence of the variant allele in the promoter of MMP2 or @GENE$ may be a protective factor for the development of @DISEASE$.

[ "1" ]

923

In conclusion, the @GENE$ blood group B allele was found to be an independent risk factor for @DISEASE$.

[ "1" ]

924

The C allele in the @GENE$ gene might be associated with the susceptibility to CAD and potentially plays an important role in the manifestation of @DISEASE$ among Chinese.

[ "1" ]

925

Despite the limited study sample, our data suggest that @GENE$ mutations might be present less frequently than KRAS mutations in Greek patients with @DISEASE$.

[ "0" ]

926

These results support the hypothesis that the African-American population is an older population compared with the other samples and the two @GENE$ receptors may play a role in @DISEASE$ pressure regulation.

[ "0" ]

927

Our results do not provide evidence for a strong involvement of @GENE$ in the development of AGA, although a @DISEASE$ role cannot be fully excluded.

[ "0" ]

928

These data suggest that the @GENE$ allele is more frequent in brain @DISEASE$ associated with large-vessel occlusion.

[ "0" ]

929

Neither @GENE$ I/D nor CYP11B2 -344C/T polymorphisms were useful to predict left ventricular mass, function or @DISEASE$ in our hypertensive patients with normal coronary arteries.

[ "0" ]

930

Our findings are consistent with the notion that genetic variation in the @GENE$ neurotransmitter system contributes to the @DISEASE$ of panic disorder.

[ "0" ]

931

These results indicate a possible association between the @GENE$ allele and an overexpression of noncognitive @DISEASE$ in AD.

[ "0" ]

932

Overtransmission of particular haplotypes of @GENE$, that may relate to the expression level of NrCAM in the brain, appeared to be associated with @DISEASE$ in the severe obsessive-compulsive behavior subset.

[ "0" ]

933

Our investigation suggests that the two promoter SNPs are unrelated to the development of @DISEASE$, however, further investigation at the promoter region of @GENE$ may be necessary to address its potential implication of gene expression in AD.

[ "1" ]

934

TT genotype of @GENE$-1055 is not an independent factor for COPD in Chinese Han people in Beijing, but increases the risk for smokers to develop @DISEASE$ and the one who has COPD family history as well.

[ "1" ]

935

We conclude from our data that @GENE$ does not play a major role in the development of @DISEASE$ in our Caucasian population.

[ "1" ]

936

The present study provides further evidence in support of the @GENE$ association with @DISEASE$ in Chinese population.

[ "1" ]

937

These observations suggest that lower expression of @GENE$ decreases the risk of @DISEASE$ by reducing the excretion of 2-hydroxyestradiol, the antiproliferative metabolite of E(2), in the endometrium.

[ "1" ]

938

This @DISEASE$ supports our hypothesis that a dominant gene within the @GENE$ region (marked by HSP70-1 and HSP70-2), but not necessarily HLA, is associated with CA in two different ethnic groups.

[ "0" ]

939

The present data indicate that mutations of @GENE$ may cause non-syndromic hearing @DISEASE$.

[ "0" ]

940

Although some molecular variants within the SLC3A1 gene were associated with clinical traits in @DISEASE$ patients, the low detection rate of mutations in this gene strongly suggests that variation of the @GENE$ is not the major genetic factor contributing to cystinuria in this Mediterranean population.

[ "1" ]

941

@GENE$ therapy reduces increased stent @DISEASE$ rates and improves clinical outcome following coronary stent implantation in patients bearing the Pl(A2)allele, suggesting that statins interfere with the functional consequence of a genetically determined platelet-mediated risk factor associated with Pl(A2)polymorphism.

[ "0" ]

942

C311S polymorphism of @GENE$ has no significant correlation with stroke in Han people of Chinese Hunan area and allele C/S is not an independent risk factor for @DISEASE$,neither is G148A.

[ "1" ]

943

In conclusion, a significant association between @DISEASE$ and @GENE$ T51C polymorphism localized on chromosome 3p21 was found.

[ "1" ]

944

These data suggest that there is a significant association between the genetic polymorphisms of @GENE$, p21, and specific combinations of the at-risk genotypes of these genes and the risk of developing @DISEASE$ in Korean women.

[ "1" ]

945

These results, in accordance with similar findings previously obtained in other ethnic groups, suggest that these two @GENE$ allelic variants may not have a direct role in the @DISEASE$ and development of obesity.

[ "0" ]

946

The SNP021 in the gene SCN7A is associated with essential hypertension of Chinese Han population in Shanghai and the role of @GENE$ gene in @DISEASE$ deserves to be further analyzed.

[ "1" ]

947

Our findings suggest that the (CCTTT)(n) repeat polymorphism in the promoter of the @GENE$ gene that affects promoter activity is a risk factor for the development of @DISEASE$, and this genetic effect seems independent of asthma.

[ "1" ]

948

These results indicate that polymorphisms in the @GENE$ gene are associated with NTG and may be a marker for the @DISEASE$.

[ "0" ]

949

These results suggest that in men, the human @GENE$ gene is associated with reduced amount of @DISEASE$ and lower insulin secretory responses to a glucose load.

[ "0" ]

950

Our data indicate polymorphism in intron 4 of the @GENE$ gene affects the occurrence of APA and may slightly modify the risk of sporadic @DISEASE$.

[ "1" ]

951

The @GENE$-V/F158 polymorphism has a significant impact on the development of @DISEASE$.

[ "0" ]

952

These findings suggest that the investigated @GENE$ genetic polymorphism does not play a major role in the pathogenesis of @DISEASE$.

[ "1" ]

953

These findings provide initial evidence that environmental risks as described by the Rutter Family Adversity Index moderate the impact of the @GENE$ gene on @DISEASE$ symptoms, suggesting a DAT1 effect only in those individuals exposed to psychosocial adversity.

[ "1" ]

954

Our findings suggest that these common @GENE$ polymorphisms do not play a major role in susceptibility to @DISEASE$ or type 2 diabetes in this population.

[ "0" ]

955

After correction for multiple comparisons, the addition of genetic information observed in the present study had little @GENE$ on risk prediction models for @DISEASE$.

[ "0" ]

956

The @GENE$ promoter SNP309 is associated with the presence of @DISEASE$ in Chinese patients especially those with H.

[ "0" ]

957

The polymorphism that confers susceptibility to @GENE$ II (@DISEASE$ in some populations is associated in United Kingdom Caucasians with enhanced microvascular function in the presence of normoglycaemia.

[ "0" ]

958

Our data suggest that neither the +36 TNFRSF1A SNP nor the +196 @GENE$ SNP is associated with @DISEASE$ severity in a population of Caucasian patients with RA.

[ "1" ]

959

These results suggested that the CTLA-4 gene might be involved in the susceptibility to @DISEASE$ in the Chinese Han population and both +49 and CT60 of @GENE$ gene might be the causal variants in RA disease.

[ "1" ]

960

We conclude, therefore, that the @GENE$-bp @DISEASE$ of the AIRE1 gene is not a susceptibility locus for the more common autoimmune endocrinopathies in the United Kingdom.

[ "0" ]

961

Our results show that the C1773 @DISEASE$ of @GENE$ increases susceptibility to hypertension, but not via hypercholesterolaemia.

[ "0" ]

962

Neither the @GENE$ K121Q nor the GLUT-1 XbaI polymorphism contribute to the genetic susceptibility of diabetic microvascular @DISEASE$ in Danish type 1 diabetic patients.

[ "0" ]

963

this large-scale evaluation of candidate @DISEASE$ genes has identified common genetic variants in the regulatory regions of @GENE$ that could be associated with bladder cancer risk.

[ "0" ]

964

These data suggest that there is a significant association between the genetic polymorphisms of p53, @GENE$, and specific combinations of the at-risk genotypes of these genes and the risk of developing @DISEASE$ in Korean women.

[ "0" ]

965

An original @DISEASE$ is the increased risk of pre-eclampsia and recurrence of pregnancy negative events, probably by modulating the maternal-fetal flow, in women homozygous for the @GENE$ 894T allele previously analyzed for the ACE I/D polymorphism.

[ "0" ]

966

These results indicate that the @GENE$ variant haplotype is functionally significant in patients with @DISEASE$, being associated with increased nuclear translocation of NF-kappaB, more severe organ dysfunction, and higher mortality.

[ "1" ]

967

None of the SNPs of KCNQ1 P448R, KCNQ1 R519H, KCNQ1 G643S, KCNE1 G38S and @GENE$ D85N was associated with @DISEASE$ phenotype, but KCNE4 E145D may relation to atrial fibrillation.

[ "1" ]

968

In conclusion, TSER genotype is not an efficacious marker for @DISEASE$ sensitivity to 5-@GENE$-based oral adjuvant chemotherapy for Japanese colorectal cancer patients after curative resection.

[ "0" ]

969

These results indicated that @GENE$ polymorphisms may be associated with the level of blood IGFBP-3 protein and an increased risk of @DISEASE$.

[ "1" ]

970

Our data support the hypothesis that the @GENE$ locus may be a significant genetic determinant for @DISEASE$ risk in whites and that women are more sensitive to the genetic effects of perilipin than men.

[ "1" ]

971

Mutations in the @GENE$ gene are unlikely to be directly causative of @DISEASE$.

[ "1" ]

972

@DISEASE$, serum folate levels and both C677T and A1298C @GENE$ mutations are associated with CVD in HD patients.

[ "0" ]

973

@GENE$ activation is present in healthy subjects at risk of developing @DISEASE$ as well as in established type 2 diabetic patients, and it is associated with impairments in the vascular reactivity in the skin microcirculation.

[ "0" ]

974

The investigated @GENE$ and 5-@DISEASE$-2A gene variants, therefore, do not seem to play a major role in SSRI antidepressant activity.

[ "0" ]

975

Based on these data, @GENE$ is not the causative gene for @DISEASE$.

[ "1" ]

976

This study suggests that possession of the @GENE$ allele with higher levels of IFN-alpha significantly increases the risk of @DISEASE$.

[ "0" ]

977

None of the SNPs of KCNQ1 P448R, KCNQ1 R519H, KCNQ1 G643S, KCNE1 G38S and @GENE$ D85N was associated with atrial fibrillation phenotype, but KCNE4 E145D may relation to @DISEASE$.

[ "1" ]

978

We conclude that IL-4-589*T, but not TNF-alpha-308*2 or Fcalpha RIbeta*G, is a risk factor for the development of @GENE$, @DISEASE$, and rhinitis by 12 mo of age.

[ "1" ]

979

These data provide no evidence that heteroallelic mutations or polymorphisms in the @GENE$ are involved in the development of @DISEASE$ early-onset MG but raise issues for future studies.

[ "0" ]

980

FAS and @GENE$ polymorphisms appear to jointly contribute to risk of @DISEASE$ in this southern Chinese population.

[ "1" ]

981

The areas of atherosclerotic lesions in @GENE$ appear to be dependent on the amount of alcohol @DISEASE$, especially in men carrying the PON1 M55 allele.

[ "0" ]

982

The present findings indicated that certain alleles or genotypes of the CNR1 gene may confer a susceptibility of @DISEASE$, especially of the hebephrenic @GENE$.

[ "0" ]

983

Consequently, the @DISEASE$ suggests that the @GENE$ polymorphism was not associated with the risk of myeloid leukemia.

[ "0" ]

984

Our results show that the 4G/4G PAI-1 genotype appears to be associated with an elevated relative risk of developing @DISEASE$, regardless of @GENE$ levels and other hypertension-related factors, in a representative sample of the Spanish population.

[ "1" ]

985

The @GENE$ variant at position -308 in the promoter region of the TNFalpha gene does not influence the amount of weight lost in @DISEASE$ and obese men and women on a 30% energy restricted diet.

[ "0" ]

986

the 660L allele may be associated with a moderately increased risk of breast cancer, but that other common SNPs in the @GENE$ gene are unlikely to be associated with a substantial risk of @DISEASE$.

[ "1" ]

987

These findings suggest that a variant in @GENE$ is not only important in the development of @DISEASE$ but also in disease progression, possibly related to enhanced airway remodelling.

[ "1" ]

988

Our results suggest @GENE$ and TIMP-2 genotypes play a crucial role in @DISEASE$ invasion, but not with development of gastric cancer.

[ "1" ]

989

These results show no evidence of an association between the @GENE$-uVNTR polymorphism and completed suicides and suggest that MAOA is not involved in the susceptibility to @DISEASE$.

[ "1" ]

990

These findings suggest that individual susceptibility of @DISEASE$ may be modulated by @GENE$ and MnSOD polymorphisms, and that the combination of genetic factors involved in oxidative stress response with environmental carcinogens may play an important role in bladder carcinogenesis.

[ "1" ]

991

These data suggest that this polymorphism of the @GENE$ gene is not associated with GD in the UK and is therefore not contributing to @DISEASE$ susceptibility in the chromosomal region designated GD-2.

[ "0" ]

992

Our results suggest that the @GENE$ Val511Ala SNP does not antagonize the effect of NSAIDs on colon cancer risk and provides support that NSAID use and the COX-2 Val511Ala SNP may contribute to a reduced risk of @DISEASE$ among African Americans.

[ "1" ]

993

Together, our findings suggest that the presence of @GENE$ gene polymorphisms may be inconclusive in the susceptibility to @DISEASE$ or in the clinical characteristics of Japanese patients with MS and, therefore, need further studies.

[ "1" ]

994

These results suggest that variation of @GENE$ may be an important determinant of @DISEASE$, in part through the mechanism of accelerated postmenopausal bone loss.

[ "0" ]

995

We conclude that @GENE$ (-174) polymorphism does not influence the risk of developing @DISEASE$ in our cohort.

[ "1" ]

996

Our results indicate for the first time that low numbers of @GENE$) PNTR and plasma Lp(a) levels are independently associated with both ischemic and @DISEASE$ in Chinese.

[ "0" ]

997

In conclusion, differences in estrogen levels due to polymorphism at the @GENE$ CYP19 gene may predispose men to increased @DISEASE$ and fracture risk.

[ "0" ]

998

(1) @GENE$ * 0405 and DRB1 * 15 are closely associated with the susceptibility to VKH syndrome, DRB1 * 0405 may be the major susceptible gene and DRB1 * 15 may be the minor; (2) DRB1 * 14 and DRB1 * 08 are negatively associated with the susceptibility to @DISEASE$, suggesting that they may be the resistant genes; (3) DRB1 * 0405 is not related to the clinical features, incidence of ocular complications as well as visual prognosis.

[ "1" ]

999

These two @GENE$ gene mutations may account for a substantial fraction of hereditary @DISEASE$.

[ "1" ]