bigbio/gad · Datasets at Hugging Face

id stringlengths 1 4	document_id stringlengths 1 4	text stringlengths 42 538	labels list
700	700	Our study implies that the G/C polymorphism of the @GENE$ gene may not be directly involved in the development and/or progression of @DISEASE$ and so it may not be useful as an independent marker in this disease.	[ "1" ]
701	701	This is the first report that demonstrates that the rare polymorphisms at codons 119 and 432 of @GENE$ gene have higher risk for @DISEASE$, and positive correlations with ERalpha and ERbeta expressions in endometrial cancer.	[ "1" ]
702	702	These results indicate that mutations in @GENE$ and NLGN4 genes are responsible for at most a small fraction of autism cases and additional screenings in other @DISEASE$ populations are needed to better determine the frequency with which mutations in NLGN3 and NLGN4 occur in autism.	[ "1" ]
703	703	The carriage of proinflammatory @GENE$-511 and @DISEASE$ vacA m1 genotypes was associated with the development of gastric IM in the Chinese.	[ "0" ]
704	704	the development of TB @DISEASE$ in Koreans was associated with shorter @GENE$ repeats in intron II of the TLR2 gene.	[ "0" ]
705	705	We found no interaction between the @GENE$ polymorphism and alcohol intake on @DISEASE$ levels and atherosclerotic markers in Southwestern France.	[ "0" ]
706	706	The beta-@GENE$ 3 W64R and ucp-1 a-3826g polymorphisms influenced the rate of the development of @DISEASE$ and may act synergistically.	[ "0" ]
707	707	These results indicate that mutations in NLGN3 and NLGN4 genes are responsible for at most a small fraction of autism cases and additional screenings in other autistic populations are needed to better determine the frequency with which mutations in @GENE$ and NLGN4 occur in @DISEASE$.	[ "1" ]
708	708	In the Amsterdam Cohort of homosexual men with @DISEASE$, the @GENE$ -589T promoter polymorphism was associated with a delayed acquisition of X4 variants but did not affect overall disease progression.	[ "1" ]
709	709	Our findings suggest interference of @GENE$ and APOE polymorphisms in the @DISEASE$ of PD, in the sense of modulating disease risk.	[ "0" ]
710	710	Observations from this study confirm earlier findings of a negative association between @GENE$13 and cervical cancer and suggest that specific DRB1-DQB1 haplotype combinations, rather than individual DQB103 alleles, increase the risk for @DISEASE$.	[ "1" ]
711	711	Overall, this meta-analysis suggests the @GENE$ gene does not independently confer a major risk to @DISEASE$ but may confer a moderate risk to PCa, especially in black men.	[ "0" ]
712	712	Our results suggest that one variant in @GENE$ gene is associated with the susceptibility of hand OA and appears to act through @DISEASE$ formation rather than cartilage damage.	[ "0" ]
713	713	The @DISEASE$ of our cohort size notwithstanding, vitamins levels in serum and genetic polymorphisms in the @GENE$ or GST genes do not appear to be important modulators of 8-oxodG levels.	[ "0" ]
714	714	This suggests that @GENE$ SNP is associated with susceptibility to @DISEASE$ and PsV, presumably by affecting the Th1/Th2 balance.	[ "0" ]
715	715	Based on our findings, it seems that genetic variations of allele -1499 and haplotype D (--/@GENE$) within the TBX21 promoter region contribute to susceptibility to @DISEASE$ infection in the Chinese population.	[ "0" ]
716	716	These findings suggest that genetic polymorphisms of @GENE$ are associated with increased risk and a disease free survival of @DISEASE$ in Korean women.	[ "1" ]
717	717	Despite the fact that our findings could not show any evidence that the @GENE$ genetic polymorphism has implications in the @DISEASE$ of spina bifida, this work represents the first description of a functional genetic polymorphism affecting the coding sequence of the human CYP26A1 gene.	[ "0" ]
718	718	Our results do not support earlier reports of an association between allele 1 in the 3'@GENE$ of the IL12B gene and @DISEASE$.	[ "0" ]
719	719	This study shows that patients with FMV/@DISEASE$ have higher frequency of @GENE$ exon 31 GG genotype that supports a role of the COL3A1 exon 31 polymorphism in determining the risk of FMV/MVP among the Chinese population in Taiwan.	[ "1" ]
720	720	This report provides further support for the hypothesis that a single nucleotide polymorphism in the @GENE$ gene is a protective factor in @DISEASE$ carcinogenesis.	[ "1" ]
721	721	We conclude, that the -159T/C polymorphism in the @GENE$ monocyte receptor gene was not associated with @DISEASE$ of coronary atherosclerosis in this population nor did it influence the efficacy of pravastatin in the treatment of atherosclerosis.	[ "0" ]
722	722	In the presence of other coexisting risk factors the @GENE$ A(1166)C but not the NOS3 G(894)T polymorphism increased the risk of @DISEASE$.	[ "1" ]
723	723	The V allele of the V89L polymorphism in the @GENE$ gene may dominantly increase the risk of @DISEASE$.	[ "1" ]
724	724	The results suggest that the @GENE$ Arg(264)Cys polymorphism modifies breast cancer risk (OR=1.5, 95% CI=1.1-2.2), especially in association with alcohol @DISEASE$ (P for interaction=0.04), whereas the CYP1B1 Leu(432)Val polymorphism appears to play no role here.	[ "0" ]
725	725	Our results significantly support @GENE$ as a susceptibility locus for @DISEASE$ and offer some support for the implication of both RGS4 and DISC1 in the etiology of schizophrenia.	[ "1" ]
726	726	Gln223Arg variant in @GENE$ gene is associated with hypertension in type II diabetic male patients, especially with elevation of systolic @DISEASE$ pressure.	[ "0" ]
727	727	These findings provide initial support for genotype-specific phenotypes for @GENE$ in autism based on ratings from the Autism Diagnostic Interview-Revised and @DISEASE$ Diagnostic Observation Schedule.	[ "1" ]
728	728	In conclusion, no association was observed between two @GENE$ variants (P844L and S845G) and @DISEASE$ risk.	[ "1" ]
729	729	The @GENE$ codon 72 polymorphism is not associated with the risk of @DISEASE$ in the present samples of Asian Indians and Chinese.	[ "1" ]
730	730	The authors suggest that genetic variants of @GENE$ are not associated with susceptibility to @DISEASE$, although the genotypes may lead to differences in disease severity and progression.	[ "0" ]
731	731	It was suggested that for the Han Chinese children with @DISEASE$ in this study, there was no association between ADHD and Val158Met polymorphism of @GENE$ gene.	[ "1" ]
732	732	The results suggest that @GENE$ variants are low-penetrance prostate cancer predisposition alleles that contribute significantly to familial clustering of @DISEASE$ at the population level.	[ "1" ]
733	733	No @GENE$ gene C566T @DISEASE$ is present in POF patients and controls.	[ "0" ]
734	734	Our results suggest that @GENE$ might be an important susceptibility gene involved in the pathogenesis of @DISEASE$.	[ "1" ]
735	735	The @GENE$ V162 allele is associated with reduced @DISEASE$ and has a substantial population-attributable risk.	[ "1" ]
736	736	The @GENE$ gene is significantly associated with RA susceptibility, suggesting the possibility that PD-1 may contribute to the @DISEASE$ of RA.	[ "0" ]
737	737	As SNPs in @GENE$ increase risk for both @DISEASE$ and multiple sclerosis, this suggests a common pathway in the pathogenesis of these diseases.	[ "0" ]
738	738	Our findings suggest that the @GENE$ 309T>G polymorphism may be used as a marker for genetic susceptibility to @DISEASE$.	[ "0" ]
739	739	LMFV and @DISEASE$ G20210A in @GENE$ gene are genetic risk factors of venous thrombosis.	[ "0" ]
740	740	In conclusion, our results do not support an association between CT60A/G polymorphism and susceptibility to RA in the Spanish population, although the contribution of other positions located within the 3' region of the @GENE$ gene to @DISEASE$ susceptibility cannot be discarded.	[ "1" ]
741	741	These results show no evidence of an association between the @GENE$-uVNTR polymorphism and completed suicides and suggest that MAOA is not involved in the susceptibility to @DISEASE$.	[ "1" ]
742	742	In conclusion, we report a novel SNP in the @GENE$ regulatory region that is associated with @DISEASE$ risk.	[ "1" ]
743	743	This @DISEASE$ suggests that @GENE$ is a potential suicide susceptibility gene and implies that dysregulation of neurogenesis may be involved in suicide.	[ "0" ]
744	744	The PPP1R3 gene 5 bp D/I within 3'-@GENE$ polymorphism taking on genetic variation among the different races of mankind may not play a critical role in the development of @DISEASE$ in Chinese Hans of Hefei region in Anhui province.	[ "0" ]
745	745	@GENE$ polymorphism (Gln223 Arg) has association with peak bone mass in young women, which may be used as genetic marker in predicting the risk of developing @DISEASE$ in Chinese women of Han nationality.	[ "0" ]
746	746	These results reveal that the @GENE$ gene polymorphism is associated with an increased risk of @DISEASE$ induced by H. pylori infection and might predispose to gastric cancer.	[ "1" ]
747	747	Consequently, the finding suggests that the @GENE$ polymorphism was not associated with the risk of @DISEASE$.	[ "1" ]
748	748	The results are supportive of @GENE$ involvement in the neurodevelopmental origin of schizophrenia and contribute in delineating etiological and pathogenetic mechanism of the schizophrenia subtype related to @DISEASE$.	[ "0" ]
749	749	The results of this study suggest that the investigated G-protein @GENE$ subunit seems to be a susceptibility factor for @DISEASE$ and maybe even for bipolar disorder, but not for schizophrenia	[ "0" ]
750	750	We conclude that the strongest association between @GENE$ gene polymorphisms and @DISEASE$ susceptibility occurs with the 3' UTR polymorphism.	[ "1" ]
751	751	The Glyl6 allele in the @GENE$-adrenergic receptor gene is a susceptibility allele for @DISEASE$ in a population of Chinese origin.	[ "0" ]
752	752	In conclusion, we found no evidence for an association between the @GENE$ polymorphisms/haplotypes tested and the risk of @DISEASE$.	[ "1" ]
753	753	The D76N variant of @GENE$ does not significantly alter insulin secretion or act as a high-risk susceptibility allele for late-onset type 2 diabetes as proposed previously, although we cannot exclude a @DISEASE$ role in increasing risk of diabetes.	[ "0" ]
754	754	We conclude that @GENE$ polymorphisms display association with @DISEASE$ due to linkage disequilibrium with Cw*0602 and is, therefore, unlikely to be directly involved in the development of psoriasis.	[ "1" ]
755	755	The 10.5-kb homozygote of @GENE$ gene is associated with a prolonged survival in patients with gastric cancer, as has been shown in the patients with @DISEASE$.	[ "0" ]
756	756	An association between this @GENE$ gene polymorphism and @DISEASE$ supports the notion that cell adhesion molecules are involved in the etiology of schizophrenia.	[ "1" ]
757	757	These data indicate that @GENE$ and beta 2 genes are not loci influencing @DISEASE$ susceptibility, either RR/SPMS or PPMS, in this population.	[ "1" ]
758	758	These results did not support any association of @GENE$ and iNOS gene polymorphisms to the development of CAL in @DISEASE$ patients in a Japanese population.	[ "1" ]
759	759	Our data explain conflicting results in the literature regarding the sequence of @GENE$ but provide no support for a direct causal role for S100A2 in @DISEASE$.	[ "1" ]
760	760	The CD36Pro90Ser @DISEASE$ is not necessarily related to the @GENE$ resistance syndrome, but is associated with high free fatty acid concentrations in Japanese.	[ "0" ]
761	761	We conclude that in top-level professional cyclists capable of completing a classic 3-wk tour @GENE$, the frequency distribution of the D allele and the @DISEASE$ genotype seems to be higher than in other endurance athletes such as elite runners (in whom the I allele is especially frequent).	[ "0" ]
762	762	Our study does not support a major contribution of @GENE$ and PGR to the @DISEASE$ of migraine.	[ "0" ]
763	763	The Ter447 variant of @GENE$ is associated with decreased risk of @DISEASE$ and coronary artery disease in our very elderly population.	[ "1" ]
764	764	@GENE$ genotype GG is associated with @DISEASE$ in patients with hereditary hemochromatosis.	[ "1" ]
765	765	The @GENE$*7 polymorphism and premature @DISEASE$ were synergistically and significantly associated in Taiwanese patients.	[ "1" ]
766	766	The use of two intragenic SNPs in both single locus and haplotype analyses of association suggests that the @GENE$ gene is a susceptibility gene in @DISEASE$.	[ "0" ]
767	767	these results may provide further support for an association between the dysbindin gene (DTNBP1) and @DISEASE$, but not between the disease and DAO, @GENE$, NRG1 and RGS4 or with the interaction of these genes.	[ "1" ]
768	768	The current results suggested that the codon 327 Asn allele in the @GENE$ gene may be related to a reduced risk of @DISEASE$ among postmenopausal women.	[ "1" ]
769	769	We found no evidence for a substantial effect of @GENE$ or LRP6 SNPs on susceptibility to @DISEASE$ or clinical characteristics of diabetic subjects in Japanese population.	[ "1" ]
770	770	In patients with coronary artery disease, the possession of the 298Asp and -786C variants of the @GENE$ gene are a risk factor for coronary in-stent @DISEASE$, demonstrating the importance of the nitric oxide system in restenosis.	[ "0" ]
771	771	We propose that although mutations in BMP15 and @GENE$ are not a major cause of @DISEASE$, they may be involved in POF.	[ "1" ]
772	772	This study indicates that the 4G/5G gene polymorphism of PAI-1 is associated with @DISEASE$, that 4G/4G type is probably an important hereditary risk factor, and that glucose has functional importance in regulating @GENE$ activity.	[ "1" ]
773	773	This suggests that the @GENE$ gene might play a role in the development of @DISEASE$ in the Lebanese population.	[ "1" ]
774	774	This, together with genetic data indicating loss of heterozygosity at the @GENE$ locus in certain human @DISEASE$ types, suggests that Sep15 may be involved in cancer development, risk, or both.	[ "0" ]
775	775	We conclude that the @GENE$ -1612 5A/6A polymorphism is associated with MI in our population, implying that individuals of the 5A allele carriers have an increased risk of @DISEASE$ MI.	[ "0" ]
776	776	No significant associations were observed with *28 allele and @DISEASE$ risk by @GENE$/progesterone receptor status.	[ "0" ]
777	777	The results of our study indicate that this @GENE$ polymorphism is not associated with the aggressiveness of @DISEASE$ in white men.	[ "1" ]
778	778	our data suggest that individuals provided with @GENE$4 and NAT110 are at a significantly lower risk for @DISEASE$, particularly when exposed to environmental risk factors.	[ "1" ]
779	779	@GENE$ was found to be an independent genetic risk factor for @DISEASE$ in Turkish population.	[ "1" ]
780	780	This study indicates a synergistic contribution of RAS genes (@GENE$ I/D, AGT T/M, AT1R T/C) and eNOS Glu298Asp polymorphisms to the development of the premature @DISEASE$.	[ "1" ]
781	781	In this prospective case-control study, the odds for women with at least one @DISEASE$ GG allele of the @GENE$ promoter to be diagnosed with PCOS was 2.7.	[ "0" ]
782	782	These findings suggested that @GENE$ gene polymorphism may be a susceptible factor to the @DISEASE$ of PIHs and the 4G/4G genotype may be one of the major risk factors for PIHs in pregnant women.	[ "0" ]
783	783	we do not deny the possible involvement of @GENE$ in @DISEASE$ but our findings do not support a major role for PXN somatic changes in lung carcinogenesis.	[ "0" ]
784	784	Our study suggests that the effect of @GENE$ gene polymorphism on @DISEASE$ risk is only observed in males and AA/AG genotype of cyclin D1 gene is associated with a higher risk of colorectal cancer in the younger patients within the Taiwanese population.	[ "1" ]
785	785	This large-scale collaborative analysis demonstrates that SNCA @GENE$ allele-length variability is associated with an increased risk of @DISEASE$.	[ "0" ]
786	786	These data imply the involvement of @GENE$ in chronic remodelling after conventional balloon angioplasty, and suggest that the 6A6A MMP3 genotype is a genetic susceptibility factor for @DISEASE$ after angioplasty without stenting.	[ "1" ]
787	787	The V allele of the V89L polymorphism in the @GENE$ gene may dominantly increase the risk of @DISEASE$.	[ "1" ]
788	788	Our data suggest that the XPA 5' non-coding region polymorphism modulates @GENE$ capacity and is associated with decreased @DISEASE$ risk, especially in the presence of exposure to tobacco carcinogens.	[ "0" ]
789	789	@DISEASE$, but not @GENE$ 677C --> T mutation, is a risk factor for venous thromboembolism in young adults without other thrombogenic factors.	[ "0" ]
790	790	The -1C to T polymorphism in the ANV gene is not associated with the risk of @DISEASE$ or @GENE$ in middle-aged Finnish males.	[ "0" ]
791	791	Consistent with results from studies of Finnish and Ashkenazi Jewish subjects, variation near the @GENE$ region of HNF4A is associated with @DISEASE$ in the Danish population.	[ "0" ]
792	792	We conclude that @GENE$ polymorphisms display association with psoriasis due to linkage disequilibrium with Cw*0602 and is, therefore, unlikely to be directly involved in the development of @DISEASE$.	[ "1" ]
793	793	5-@GENE$ gene -1438G/A polymorphism was probably not associated with @DISEASE$-induced weight gain in Chinese Han patients with schizophrenia in this study.	[ "0" ]
794	794	These findings suggest that 677CT polymorphism in @GENE$ may be a genetic susceptibility factor for @DISEASE$ among Chinese women.	[ "1" ]
795	795	Thus, the polymorphic alleles of SHTR2A proved to be associated with @DISEASE$ @GENE$ in mentally healthy people.	[ "0" ]
796	796	@DISEASE$ screening of the @GENE$ gene in 156 men with azoospermia or severe oligozoospermia revealed no relevant mutations; thus, mutations in BOULE can be eliminated as a major cause of impaired spermatogenesis.	[ "0" ]
797	797	Deteriorating gallbladder @DISEASE$, possibly induced by alterations in the @GENE$ gene, as well as CCK-AR gene polymorphism, promoted gallstone formation.	[ "0" ]
798	798	The @GENE$ gene is an interesting novel candidate for @DISEASE$ because it encodes an amino acid transporter, which potentially regulates tryptophan availability for serotonin synthesis and thus possibly affects appetite control.	[ "1" ]
799	799	Multivariate analysis of these correlated phenotypes also yielded a highly significant association (P = 0.0004), suggesting that @GENE$ may influence phenotypic variation in @DISEASE$-related traits.	[ "1" ]

700

Our study implies that the G/C polymorphism of the @GENE$ gene may not be directly involved in the development and/or progression of @DISEASE$ and so it may not be useful as an independent marker in this disease.

[ "1" ]

701

This is the first report that demonstrates that the rare polymorphisms at codons 119 and 432 of @GENE$ gene have higher risk for @DISEASE$, and positive correlations with ERalpha and ERbeta expressions in endometrial cancer.

[ "1" ]

702

These results indicate that mutations in @GENE$ and NLGN4 genes are responsible for at most a small fraction of autism cases and additional screenings in other @DISEASE$ populations are needed to better determine the frequency with which mutations in NLGN3 and NLGN4 occur in autism.

[ "1" ]

703

The carriage of proinflammatory @GENE$-511 and @DISEASE$ vacA m1 genotypes was associated with the development of gastric IM in the Chinese.

[ "0" ]

704

the development of TB @DISEASE$ in Koreans was associated with shorter @GENE$ repeats in intron II of the TLR2 gene.

[ "0" ]

705

We found no interaction between the @GENE$ polymorphism and alcohol intake on @DISEASE$ levels and atherosclerotic markers in Southwestern France.

[ "0" ]

706

The beta-@GENE$ 3 W64R and ucp-1 a-3826g polymorphisms influenced the rate of the development of @DISEASE$ and may act synergistically.

[ "0" ]

707

These results indicate that mutations in NLGN3 and NLGN4 genes are responsible for at most a small fraction of autism cases and additional screenings in other autistic populations are needed to better determine the frequency with which mutations in @GENE$ and NLGN4 occur in @DISEASE$.

[ "1" ]

708

In the Amsterdam Cohort of homosexual men with @DISEASE$, the @GENE$ -589T promoter polymorphism was associated with a delayed acquisition of X4 variants but did not affect overall disease progression.

[ "1" ]

709

Our findings suggest interference of @GENE$ and APOE polymorphisms in the @DISEASE$ of PD, in the sense of modulating disease risk.

[ "0" ]

710

Observations from this study confirm earlier findings of a negative association between @GENE$*13 and cervical cancer and suggest that specific DRB1-DQB1 haplotype combinations, rather than individual DQB1*03 alleles, increase the risk for @DISEASE$.

[ "1" ]

711

Overall, this meta-analysis suggests the @GENE$ gene does not independently confer a major risk to @DISEASE$ but may confer a moderate risk to PCa, especially in black men.

[ "0" ]

712

Our results suggest that one variant in @GENE$ gene is associated with the susceptibility of hand OA and appears to act through @DISEASE$ formation rather than cartilage damage.

[ "0" ]

713

The @DISEASE$ of our cohort size notwithstanding, vitamins levels in serum and genetic polymorphisms in the @GENE$ or GST genes do not appear to be important modulators of 8-oxodG levels.

[ "0" ]

714

This suggests that @GENE$ SNP is associated with susceptibility to @DISEASE$ and PsV, presumably by affecting the Th1/Th2 balance.

[ "0" ]

715

Based on our findings, it seems that genetic variations of allele -1499 and haplotype D (--/@GENE$) within the TBX21 promoter region contribute to susceptibility to @DISEASE$ infection in the Chinese population.

[ "0" ]

716

These findings suggest that genetic polymorphisms of @GENE$ are associated with increased risk and a disease free survival of @DISEASE$ in Korean women.

[ "1" ]

717

Despite the fact that our findings could not show any evidence that the @GENE$ genetic polymorphism has implications in the @DISEASE$ of spina bifida, this work represents the first description of a functional genetic polymorphism affecting the coding sequence of the human CYP26A1 gene.

[ "0" ]

718

Our results do not support earlier reports of an association between allele 1 in the 3'@GENE$ of the IL12B gene and @DISEASE$.

[ "0" ]

719

This study shows that patients with FMV/@DISEASE$ have higher frequency of @GENE$ exon 31 GG genotype that supports a role of the COL3A1 exon 31 polymorphism in determining the risk of FMV/MVP among the Chinese population in Taiwan.

[ "1" ]

720

This report provides further support for the hypothesis that a single nucleotide polymorphism in the @GENE$ gene is a protective factor in @DISEASE$ carcinogenesis.

[ "1" ]

721

We conclude, that the -159T/C polymorphism in the @GENE$ monocyte receptor gene was not associated with @DISEASE$ of coronary atherosclerosis in this population nor did it influence the efficacy of pravastatin in the treatment of atherosclerosis.

[ "0" ]

722

In the presence of other coexisting risk factors the @GENE$ A(1166)C but not the NOS3 G(894)T polymorphism increased the risk of @DISEASE$.

[ "1" ]

723

The V allele of the V89L polymorphism in the @GENE$ gene may dominantly increase the risk of @DISEASE$.

[ "1" ]

724

The results suggest that the @GENE$ Arg(264)Cys polymorphism modifies breast cancer risk (OR=1.5, 95% CI=1.1-2.2), especially in association with alcohol @DISEASE$ (P for interaction=0.04), whereas the CYP1B1 Leu(432)Val polymorphism appears to play no role here.

[ "0" ]

725

Our results significantly support @GENE$ as a susceptibility locus for @DISEASE$ and offer some support for the implication of both RGS4 and DISC1 in the etiology of schizophrenia.

[ "1" ]

726

Gln223Arg variant in @GENE$ gene is associated with hypertension in type II diabetic male patients, especially with elevation of systolic @DISEASE$ pressure.

[ "0" ]

727

These findings provide initial support for genotype-specific phenotypes for @GENE$ in autism based on ratings from the Autism Diagnostic Interview-Revised and @DISEASE$ Diagnostic Observation Schedule.

[ "1" ]

728

In conclusion, no association was observed between two @GENE$ variants (P844L and S845G) and @DISEASE$ risk.

[ "1" ]

729

The @GENE$ codon 72 polymorphism is not associated with the risk of @DISEASE$ in the present samples of Asian Indians and Chinese.

[ "1" ]

730

The authors suggest that genetic variants of @GENE$ are not associated with susceptibility to @DISEASE$, although the genotypes may lead to differences in disease severity and progression.

[ "0" ]

731

It was suggested that for the Han Chinese children with @DISEASE$ in this study, there was no association between ADHD and Val158Met polymorphism of @GENE$ gene.

[ "1" ]

732

The results suggest that @GENE$ variants are low-penetrance prostate cancer predisposition alleles that contribute significantly to familial clustering of @DISEASE$ at the population level.

[ "1" ]

733

No @GENE$ gene C566T @DISEASE$ is present in POF patients and controls.

[ "0" ]

734

Our results suggest that @GENE$ might be an important susceptibility gene involved in the pathogenesis of @DISEASE$.

[ "1" ]

735

The @GENE$ V162 allele is associated with reduced @DISEASE$ and has a substantial population-attributable risk.

[ "1" ]

736

The @GENE$ gene is significantly associated with RA susceptibility, suggesting the possibility that PD-1 may contribute to the @DISEASE$ of RA.

[ "0" ]

737

As SNPs in @GENE$ increase risk for both @DISEASE$ and multiple sclerosis, this suggests a common pathway in the pathogenesis of these diseases.

[ "0" ]

738

Our findings suggest that the @GENE$ 309T>G polymorphism may be used as a marker for genetic susceptibility to @DISEASE$.

[ "0" ]

739

LMFV and @DISEASE$ G20210A in @GENE$ gene are genetic risk factors of venous thrombosis.

[ "0" ]

740

In conclusion, our results do not support an association between CT60A/G polymorphism and susceptibility to RA in the Spanish population, although the contribution of other positions located within the 3' region of the @GENE$ gene to @DISEASE$ susceptibility cannot be discarded.

[ "1" ]

741

These results show no evidence of an association between the @GENE$-uVNTR polymorphism and completed suicides and suggest that MAOA is not involved in the susceptibility to @DISEASE$.

[ "1" ]

742

In conclusion, we report a novel SNP in the @GENE$ regulatory region that is associated with @DISEASE$ risk.

[ "1" ]

743

This @DISEASE$ suggests that @GENE$ is a potential suicide susceptibility gene and implies that dysregulation of neurogenesis may be involved in suicide.

[ "0" ]

744

The PPP1R3 gene 5 bp D/I within 3'-@GENE$ polymorphism taking on genetic variation among the different races of mankind may not play a critical role in the development of @DISEASE$ in Chinese Hans of Hefei region in Anhui province.

[ "0" ]

745

@GENE$ polymorphism (Gln223 Arg) has association with peak bone mass in young women, which may be used as genetic marker in predicting the risk of developing @DISEASE$ in Chinese women of Han nationality.

[ "0" ]

746

These results reveal that the @GENE$ gene polymorphism is associated with an increased risk of @DISEASE$ induced by H. pylori infection and might predispose to gastric cancer.

[ "1" ]

747

Consequently, the finding suggests that the @GENE$ polymorphism was not associated with the risk of @DISEASE$.

[ "1" ]

748

The results are supportive of @GENE$ involvement in the neurodevelopmental origin of schizophrenia and contribute in delineating etiological and pathogenetic mechanism of the schizophrenia subtype related to @DISEASE$.

[ "0" ]

749

The results of this study suggest that the investigated G-protein @GENE$ subunit seems to be a susceptibility factor for @DISEASE$ and maybe even for bipolar disorder, but not for schizophrenia

[ "0" ]

750

We conclude that the strongest association between @GENE$ gene polymorphisms and @DISEASE$ susceptibility occurs with the 3' UTR polymorphism.

[ "1" ]

751

The Glyl6 allele in the @GENE$-adrenergic receptor gene is a susceptibility allele for @DISEASE$ in a population of Chinese origin.

[ "0" ]

752

In conclusion, we found no evidence for an association between the @GENE$ polymorphisms/haplotypes tested and the risk of @DISEASE$.

[ "1" ]

753

The D76N variant of @GENE$ does not significantly alter insulin secretion or act as a high-risk susceptibility allele for late-onset type 2 diabetes as proposed previously, although we cannot exclude a @DISEASE$ role in increasing risk of diabetes.

[ "0" ]

754

We conclude that @GENE$ polymorphisms display association with @DISEASE$ due to linkage disequilibrium with Cw*0602 and is, therefore, unlikely to be directly involved in the development of psoriasis.

[ "1" ]

755

The 10.5-kb homozygote of @GENE$ gene is associated with a prolonged survival in patients with gastric cancer, as has been shown in the patients with @DISEASE$.

[ "0" ]

756

An association between this @GENE$ gene polymorphism and @DISEASE$ supports the notion that cell adhesion molecules are involved in the etiology of schizophrenia.

[ "1" ]

757

These data indicate that @GENE$ and beta 2 genes are not loci influencing @DISEASE$ susceptibility, either RR/SPMS or PPMS, in this population.

[ "1" ]

758

These results did not support any association of @GENE$ and iNOS gene polymorphisms to the development of CAL in @DISEASE$ patients in a Japanese population.

[ "1" ]

759

Our data explain conflicting results in the literature regarding the sequence of @GENE$ but provide no support for a direct causal role for S100A2 in @DISEASE$.

[ "1" ]

760

The CD36Pro90Ser @DISEASE$ is not necessarily related to the @GENE$ resistance syndrome, but is associated with high free fatty acid concentrations in Japanese.

[ "0" ]

761

We conclude that in top-level professional cyclists capable of completing a classic 3-wk tour @GENE$, the frequency distribution of the D allele and the @DISEASE$ genotype seems to be higher than in other endurance athletes such as elite runners (in whom the I allele is especially frequent).

[ "0" ]

762

Our study does not support a major contribution of @GENE$ and PGR to the @DISEASE$ of migraine.

[ "0" ]

763

The Ter447 variant of @GENE$ is associated with decreased risk of @DISEASE$ and coronary artery disease in our very elderly population.

[ "1" ]

764

@GENE$ genotype GG is associated with @DISEASE$ in patients with hereditary hemochromatosis.

[ "1" ]

765

The @GENE$*7 polymorphism and premature @DISEASE$ were synergistically and significantly associated in Taiwanese patients.

[ "1" ]

766

The use of two intragenic SNPs in both single locus and haplotype analyses of association suggests that the @GENE$ gene is a susceptibility gene in @DISEASE$.

[ "0" ]

767

these results may provide further support for an association between the dysbindin gene (DTNBP1) and @DISEASE$, but not between the disease and DAO, @GENE$, NRG1 and RGS4 or with the interaction of these genes.

[ "1" ]

768

The current results suggested that the codon 327 Asn allele in the @GENE$ gene may be related to a reduced risk of @DISEASE$ among postmenopausal women.

[ "1" ]

769

We found no evidence for a substantial effect of @GENE$ or LRP6 SNPs on susceptibility to @DISEASE$ or clinical characteristics of diabetic subjects in Japanese population.

[ "1" ]

770

In patients with coronary artery disease, the possession of the 298Asp and -786C variants of the @GENE$ gene are a risk factor for coronary in-stent @DISEASE$, demonstrating the importance of the nitric oxide system in restenosis.

[ "0" ]

771

We propose that although mutations in BMP15 and @GENE$ are not a major cause of @DISEASE$, they may be involved in POF.

[ "1" ]

772

This study indicates that the 4G/5G gene polymorphism of PAI-1 is associated with @DISEASE$, that 4G/4G type is probably an important hereditary risk factor, and that glucose has functional importance in regulating @GENE$ activity.

[ "1" ]

773

This suggests that the @GENE$ gene might play a role in the development of @DISEASE$ in the Lebanese population.

[ "1" ]

774

This, together with genetic data indicating loss of heterozygosity at the @GENE$ locus in certain human @DISEASE$ types, suggests that Sep15 may be involved in cancer development, risk, or both.

[ "0" ]

775

We conclude that the @GENE$ -1612 5A/6A polymorphism is associated with MI in our population, implying that individuals of the 5A allele carriers have an increased risk of @DISEASE$ MI.

[ "0" ]

776

No significant associations were observed with *28 allele and @DISEASE$ risk by @GENE$/progesterone receptor status.

[ "0" ]

777

The results of our study indicate that this @GENE$ polymorphism is not associated with the aggressiveness of @DISEASE$ in white men.

[ "1" ]

778

our data suggest that individuals provided with @GENE$*4 and NAT1*10 are at a significantly lower risk for @DISEASE$, particularly when exposed to environmental risk factors.

[ "1" ]

779

@GENE$ was found to be an independent genetic risk factor for @DISEASE$ in Turkish population.

[ "1" ]

780

This study indicates a synergistic contribution of RAS genes (@GENE$ I/D, AGT T/M, AT1R T/C) and eNOS Glu298Asp polymorphisms to the development of the premature @DISEASE$.

[ "1" ]

781

In this prospective case-control study, the odds for women with at least one @DISEASE$ GG allele of the @GENE$ promoter to be diagnosed with PCOS was 2.7.

[ "0" ]

782

These findings suggested that @GENE$ gene polymorphism may be a susceptible factor to the @DISEASE$ of PIHs and the 4G/4G genotype may be one of the major risk factors for PIHs in pregnant women.

[ "0" ]

783

we do not deny the possible involvement of @GENE$ in @DISEASE$ but our findings do not support a major role for PXN somatic changes in lung carcinogenesis.

[ "0" ]

784

Our study suggests that the effect of @GENE$ gene polymorphism on @DISEASE$ risk is only observed in males and AA/AG genotype of cyclin D1 gene is associated with a higher risk of colorectal cancer in the younger patients within the Taiwanese population.

[ "1" ]

785

This large-scale collaborative analysis demonstrates that SNCA @GENE$ allele-length variability is associated with an increased risk of @DISEASE$.

[ "0" ]

786

These data imply the involvement of @GENE$ in chronic remodelling after conventional balloon angioplasty, and suggest that the 6A6A MMP3 genotype is a genetic susceptibility factor for @DISEASE$ after angioplasty without stenting.

[ "1" ]

787

The V allele of the V89L polymorphism in the @GENE$ gene may dominantly increase the risk of @DISEASE$.

[ "1" ]

788

Our data suggest that the XPA 5' non-coding region polymorphism modulates @GENE$ capacity and is associated with decreased @DISEASE$ risk, especially in the presence of exposure to tobacco carcinogens.

[ "0" ]

789

@DISEASE$, but not @GENE$ 677C --> T mutation, is a risk factor for venous thromboembolism in young adults without other thrombogenic factors.

[ "0" ]

790

The -1C to T polymorphism in the ANV gene is not associated with the risk of @DISEASE$ or @GENE$ in middle-aged Finnish males.

[ "0" ]

791

Consistent with results from studies of Finnish and Ashkenazi Jewish subjects, variation near the @GENE$ region of HNF4A is associated with @DISEASE$ in the Danish population.

[ "0" ]

792

We conclude that @GENE$ polymorphisms display association with psoriasis due to linkage disequilibrium with Cw*0602 and is, therefore, unlikely to be directly involved in the development of @DISEASE$.

[ "1" ]

793

5-@GENE$ gene -1438G/A polymorphism was probably not associated with @DISEASE$-induced weight gain in Chinese Han patients with schizophrenia in this study.

[ "0" ]

794

These findings suggest that 677CT polymorphism in @GENE$ may be a genetic susceptibility factor for @DISEASE$ among Chinese women.

[ "1" ]

795

Thus, the polymorphic alleles of SHTR2A proved to be associated with @DISEASE$ @GENE$ in mentally healthy people.

[ "0" ]

796

@DISEASE$ screening of the @GENE$ gene in 156 men with azoospermia or severe oligozoospermia revealed no relevant mutations; thus, mutations in BOULE can be eliminated as a major cause of impaired spermatogenesis.

[ "0" ]

797

Deteriorating gallbladder @DISEASE$, possibly induced by alterations in the @GENE$ gene, as well as CCK-AR gene polymorphism, promoted gallstone formation.

[ "0" ]

798

The @GENE$ gene is an interesting novel candidate for @DISEASE$ because it encodes an amino acid transporter, which potentially regulates tryptophan availability for serotonin synthesis and thus possibly affects appetite control.

[ "1" ]

799

Multivariate analysis of these correlated phenotypes also yielded a highly significant association (P = 0.0004), suggesting that @GENE$ may influence phenotypic variation in @DISEASE$-related traits.

[ "1" ]