bigbio/gad · Datasets at Hugging Face

id stringlengths 1 4	document_id stringlengths 1 4	text stringlengths 42 538	labels list
500	500	The use of endophenotypic markers for @DISEASE$ such as the mood response to @GENE$ depletion may facilitate studies of complex genetic traits such as depression by decreasing its heterogeneity.	[ "0" ]
501	501	These data suggest that the @GENE$(*)1B is associated with smoking @DISEASE$ in white and intermediate, but not black Brazilians.	[ "0" ]
502	502	These results suggest that TCF7L2 variants may act through @GENE$ secretion to increase the risk of @DISEASE$.	[ "0" ]
503	503	These results provide substantial evidence that genetic variation within or extremely close to @GENE$ impacts both disease risk and traits related to the severity of @DISEASE$.	[ "1" ]
504	504	Our results suggest that the COX-2 Val511Ala SNP does not antagonize the effect of NSAIDs on colon cancer risk and provides support that NSAID use and the @GENE$ Val511Ala SNP may contribute to a reduced risk of @DISEASE$ among African Americans.	[ "1" ]
505	505	A genetic variant in @GENE$ was consistently associated with knee @DISEASE$ in 3 samples from 2 populations.	[ "1" ]
506	506	The risk of @DISEASE$ is not strongly associated with the I105V and A114V polymorphisms in the GSTP1 gene or with @GENE$ intron 6 polymorphism.	[ "1" ]
507	507	Our findings suggest that the C19007T @GENE$ polymorphism is unlikely to play an important role in epithelial ovarian or @DISEASE$ in Korean women.	[ "0" ]
508	508	The presence of the Asp299Gly allele of the @GENE$ gene does not seem to exert a major influence on the progression of @DISEASE$ in patients with FH.	[ "1" ]
509	509	These findings suggest that the @GENE$ 838G/A and GMNN 387C/A polymorphisms may not play a major role in the etiology of @DISEASE$, but CDT1 variant may have a potential role only in genetically susceptible women.	[ "1" ]
510	510	Our data suggest that genetic variation in the @GENE$ gene may modify the risk of @DISEASE$ in an APOE*4-dependent fashion.	[ "1" ]
511	511	Although there is a tendency of higher diastolic blood pressure in men with DD genotypes, there is no convincing evidence that @GENE$ genotypes are associated with @DISEASE$ in this Japanese population.	[ "1" ]
512	512	Two novel mutations in @GENE$ may be mutations characterized to @DISEASE$ of Chinese Shanghai population.	[ "0" ]
513	513	Individuals with less active @GENE$-uVNTR alleles may be at increased risk for @DISEASE$ and poor sleep.	[ "0" ]
514	514	Our results suggest that an interaction between COMT and @GENE$ genotypes may predict the treatment response to typical neuroleptics in patients with @DISEASE$.	[ "1" ]
515	515	linkage of the human @GENE$ gene to IDDM in a subset of patients supports a pathogenic role of nitric oxide in human @DISEASE$.	[ "1" ]
516	516	Our data do not support a significant genetic contribution of @GENE$ polymorphisms and haplotypes to affective psychosis, and the findings are inconclusive regarding their contribution to @DISEASE$-related traits.	[ "0" ]
517	517	These data, showing for the first time that @GENE$ polymorphism mediates susceptibility, are compatible with reports showing that PTCH @DISEASE$ influences development of BCC precursor lesions.	[ "0" ]
518	518	These data support a role for @GENE$ in the @DISEASE$ of ARDS and its associated physiological derangement.	[ "0" ]
519	519	Although these data do not preclude the possibility of an increased risk of @DISEASE$ in association with the Cowden syndrome, they indicate that germline @GENE$ mutations do not account for a significant proportion of genetic attributable risk for endometrial carcinoma.	[ "1" ]
520	520	The Trp64Arg @DISEASE$ of the @GENE$-adr gene may predict the result of dietary intervention in obese children to some extent, but it was not a major factor affecting weight in Chinese children.	[ "0" ]
521	521	These results indicated that G-33A polymorphism in @GENE$ might be a genetic risk factor for @DISEASE$.	[ "1" ]
522	522	our data suggests that the @GENE$ D allele is a modest risk factor for late-onset sporadic AD in Koreans, and the @DISEASE$ risk conferred by the A2M D allele increases in APOE epsilon4 negative subjects.	[ "1" ]
523	523	The eNOS G894T or eNOS 894TT genotypes in combination with the MTHFR 677TT or @GENE$ D/D genotype increases the risk of @DISEASE$.	[ "1" ]
524	524	The results seem to reflect a different susceptibility of MMP-2 as well as of some associated @GENE$ and ET-1 genotypes to @DISEASE$.	[ "1" ]
525	525	The data are compatible with certain missense mutations in @GENE$ predisposing to @DISEASE$.	[ "1" ]
526	526	The IVS1a+465C allele of the @GENE$ gene, which reduces expression of the gene, is a risk factor for @DISEASE$, especially the paranoid subtype.	[ "1" ]
527	527	These studies support that MEF2A mutations are not a common cause of CAD in white people and argue strongly against a role for the @GENE$ 21-bp deletion in autosomal dominant @DISEASE$.	[ "1" ]
528	528	We conclude that the @GENE$ polymorphism is unlikely to be a major risk factor in the @DISEASE$ of these major psychiatric disorders although there could be a small effect in schizophrenia.	[ "0" ]
529	529	This case-control study showed no significant association between @GENE$ gene polymorphisms and the risk of young-onset prostate cancer, suggesting that genetic variations in OBR are unlikely to have a major role in the development of early-onset @DISEASE$ in the UK.	[ "1" ]
530	530	These data suggest that the @GENE$ 469KK genotype could be a genetic risk factor for retinopathy in @DISEASE$.	[ "1" ]
531	531	In this study of @DISEASE$ patients, SCD was not related to polymorphisms in the @GENE$ gene.	[ "1" ]
532	532	These data highlight the crucial role of @GENE$ in the clinical outcome of @DISEASE$, as it has recently been shown that the mannose binding lectin gene is a modulating gene of the respiratory involvement in cystic fibrosis patients.	[ "0" ]
533	533	The results suggest that the BDNF C-270T polymorphism is a relevant risk factor for @DISEASE$ particularly in patients lacking the @GENE$ epsilon4 allele in this German sample.	[ "1" ]
534	534	These results suggest that apoE and @GENE$ may be part of a complex mechanism in the pathogenesis of @DISEASE$.	[ "1" ]
535	535	A significant portion of @DISEASE$ is associated with @GENE$ epsilon4 in the general population.	[ "1" ]
536	536	The results suggested that the T(-344)C polymorphism of @GENE$ gene may be associated with @DISEASE$ in female Kazakh population of Xinjiang Barlikun area.	[ "1" ]
537	537	These results do not support the hypothesis that @GENE$ L10P genotypes modify the risk of breast cancer in BRCA1 or @DISEASE$ carriers.	[ "0" ]
538	538	These findings suggest a role for the @GENE$ gene in @DISEASE$ susceptibility and imply that this role may be realized at least in part by the induction of increases in hK2 production.	[ "1" ]
539	539	Our results suggest that @GENE$, COMT, 5-HT2A, DRD2, and DRD4 gene variants are not involved in susceptibility toward different time courses in @DISEASE$.	[ "1" ]
540	540	The TF @GENE$ variant did not confer a risk for @DISEASE$ in Koreans.	[ "0" ]
541	541	Our data therefore suggests that the @GENE$ and A2aAR genes do not play major roles in the development of this @DISEASE$.	[ "0" ]
542	542	Sequence variants at the @GENE$ genomic locus may influence risk of @DISEASE$ in humans.	[ "1" ]
543	543	Our data suggest both TNF and @GENE$ genes are not major susceptibility genes for @DISEASE$.	[ "0" ]
544	544	The present study demonstrates that the CC genotype of the -634 C/G @GENE$ gene might be a risk factor for @DISEASE$ in Caucasians with type 2 diabetes of duration of more than 10 years.	[ "1" ]
545	545	Based on statistical analysis homozygosity for nonconservative mutations in the coding region of the @GENE$ gene is estimated @DISEASE$/300 000 when a white Caucasian population is considered, arguing against an important role of mutations of this coding region in hypertension and hypertension-associated progression of renal disease.	[ "0" ]
546	546	The rs1800947 SNP and the C-C-C haplotype in the @GENE$ gene appear to be prognostic markers of @DISEASE$ and this polymorphism could be a useful genetic marker.	[ "1" ]
547	547	Findings from this general population sample could not confirm the hypothesis that @GENE$ moderates the relationship between adolescent maltreatment and adolescent or @DISEASE$.	[ "0" ]
548	548	Genotype for @GENE$ may prove reliable for assessment of genetic risk for @DISEASE$.	[ "1" ]
549	549	Results do not support any overall association of the Ala-9Val @GENE$ polymorphism to the development of @DISEASE$.	[ "1" ]
550	550	These results suggested that the variant might act as a functional genetic factor of @DISEASE$ with a unique mechanism to upregulate local and systemic @GENE$ concentration in vivo.	[ "1" ]
551	551	The @GENE$ promoter genotype that controls the degree of HO-1 up-regulation in response to stress stimuli is associated with the postintervention @DISEASE$ and the restenosis risk after balloon angioplasty.	[ "0" ]
552	552	Our results suggest that @GENE$ genetic variations do not appear to be major determinants for @DISEASE$ susceptibility in the Taiwanese population.	[ "1" ]
553	553	In conclusion, our results do not support the hypothesis of an important role of common genetic variation in @GENE$ for the development of @DISEASE$ in our sample.	[ "1" ]
554	554	The observation of frequency differences between cases and controls in two independent samples strongly suggests that the @GENE$ gene is involved as a risk factor for developing @DISEASE$ at a young age, but the identified polymorphisms are probably acting as markers for an unidentified functional mutation elsewhere in the gene locus.	[ "1" ]
555	555	The common @GENE$ allelic variant was associated with increased @DISEASE$ survival and with reduced tumor infiltration by microglia.	[ "0" ]
556	556	These results do not support the hypothesis that @GENE$ L10P genotypes modify the risk of @DISEASE$ in BRCA1 or BRCA2 mutation carriers.	[ "1" ]
557	557	Our studies suggest that a T-to-C substitution at -586 of the @GENE$ promoter is associated with a lowered @DISEASE$ activity and that this variation may contribute to the increased plasma HDL-C concentration in the Chinese.	[ "0" ]
558	558	Polymorphisms of @GENE$ and CCR5 do not seem to be involved in susceptibility to @DISEASE$, although a slight contribution of the CCR5 polymorphism in the production of anti-dsDNA autoantibodies, in the development of lupus nephritis, and in the outcome of the disease could be postulated.	[ "0" ]
559	559	no association between @GENE$ T98P genotype and the phenotype of the benign or @DISEASE$ was observed.	[ "1" ]
560	560	Thus, the present study provided no evidence for statistically significant associations between the @GENE$ polymorphisms and the @DISEASE$ traits.	[ "0" ]
561	561	These results support the hypothesis that these @GENE$ mutations represent major gene effects for @DISEASE$.	[ "1" ]
562	562	These findings indicate that in patients without a clinical diagnosis of CF, @GENE$ gene mutations could be involved in the development of @DISEASE$, in association with other genetic or environmental factors.	[ "1" ]
563	563	@GENE$, II genotype carrier females may have increased risk for @DISEASE$.	[ "0" ]
564	564	These associations suggest that the @GENE$ region also determines susceptibility to spinal disc degeneration and CMC1 @DISEASE$.	[ "1" ]
565	565	These observations suggest that lower expression of UGT1A1 decreases the risk of @DISEASE$ by reducing the excretion of 2-hydroxyestradiol, the antiproliferative metabolite of @GENE$), in the endometrium.	[ "0" ]
566	566	Although there was little statistical power to detect modest increases in risk for the homozygote variant genotypes, particularly for the rare @GENE$ and XRCC2 variants, the data suggest that none of these variants play a major role in the etiology of breast or @DISEASE$.	[ "0" ]
567	567	Combining the two 'candidate' SNPs (P187S and R72P) revealed an increased risk for @DISEASE$ of double heterozygotes (P187S/R72P) of the @GENE$ and TP53 genes (OR=1.88; 95% CI 1.13-3.15; P=0.011), suggesting a possible interaction of these two loci.	[ "1" ]
568	568	The CYP1A1 Ile-Val gene polymorphisms might be associated with the occurrence of @DISEASE$, while MspI gene polymorphisms and @GENE$ slow acetylator genotype might not be associated with the occurrence of prostate cancer.	[ "1" ]
569	569	This study provides insights into the genetic @DISEASE$ of @GENE$.	[ "0" ]
570	570	Thus, in addition to the antigen-driven excess Th2 response, increased T-bet (and subsequent @GENE$) production in human airways of individuals with the -1993T-->C polymorphism could contribute to the development of certain @DISEASE$-related phenotypes, such as AIA.	[ "0" ]
571	571	the data indicates the G allele of MDM2 SNP309 might have a protective effect on disease development in HNPCC patients and that age of diagnosis of @DISEASE$ is not associated with @GENE$ SNP309 or TP53 R72P either as single SNPs or combined.	[ "1" ]
572	572	we have found evidence that a single tagged SNP in both the CDKN2A and @GENE$ genes may be associated with reduced @DISEASE$ risk.	[ "1" ]
573	573	Although the @GENE$08-DQA10401-DQB1*04 haplotype was significantly associated with @DISEASE$, consistent with other studies, this haplotype nevertheless represented only 19% (14/72) of all PBC patients and can account for only a minority of the risk of PBC.	[ "0" ]
574	574	The @DISEASE$ of this polymorphism, the small sample size and the heterogeneous ethnic backgrounds of participants in the @GENE$ study allow only tentative conclusions based on the results, thus the role of the opioid receptor in pain and opioid reward response remains uncertain.	[ "0" ]
575	575	7216A/G polymorphism of @GENE$ gene may be one of the genetic factors that determine the presence of anti-@DISEASE$-A/Ro52 antibody in patients with primary SS.	[ "0" ]
576	576	A panel of thrombogenic gene mutations consisting of factor V G1691A, factor V H1299R (@GENE$), factor II prothrombin G20210A, factor XIII V34L, beta-fibrinogen -455G>A, PAI-1 4G/5G, HPA1 a/b(L33P), MTHFR C677T, and MTHFR A1298C can identify individuals at risk for @DISEASE$.	[ "0" ]
577	577	The SNP021 in the gene @GENE$ is associated with @DISEASE$ of Chinese Han population in Shanghai and the role of SCN7A gene in hypertension deserves to be further analyzed.	[ "0" ]
578	578	It is unlikely that the @GENE$ gene is a locus responsible for @DISEASE$.	[ "1" ]
579	579	Tunisian persons carrying the @GENE$ A1/A3 genotype may have an increased risk of severe @DISEASE$.	[ "0" ]
580	580	We find no evidence to support an association between @GENE$ genotype and either the diagnosis of idiopathic dilated cardiomyopathy itself or @DISEASE$ of the disease.	[ "0" ]
581	581	Our data showed that the APOE epsilon4 allele frequency in AD was significantly higher than that in the normal controls (chi2 = 11.66, P < 0.01) neither the frequencies of genotypes nor alleles of the TNF alpha-308 A/G and @GENE$ polymorphisms were significantly different between @DISEASE$ and controls,suggesting the two polymorphisms were not risk factors to LOAD in Chinese.	[ "1" ]
582	582	our data suggest that GST and @GENE$ genotypes are not associated with the susceptibility to @DISEASE$ or its outcome in the Brazilian population.	[ "1" ]
583	583	The present study indicated the @GENE$ B haplotype as a putative risk factor for @DISEASE$ in PGRN mutations negative patients.	[ "1" ]
584	584	This is the first study to report a significant association between the @GENE$ gene and @DISEASE$.	[ "0" ]
585	585	We conclude that in @GENE$*3-Leiden allele carriers FD is dominantly inherited with a high rate of penetrance, i.e., the presence of normally functioning apoE molecules in the plasma does not prevent the age-related expression of this @DISEASE$.	[ "0" ]
586	586	Homozygosity for the T677 allele of the @GENE$ gene, although slightly more prevalent in patients compared to controls, has not been found in association with @DISEASE$.	[ "1" ]
587	587	These results suggest that @GENE$ might play a role in genetic susceptibility to @DISEASE$.	[ "1" ]
588	588	The study demonstrates that patients who develop myalgia while taking atorvastatin are more likely to experience a greater degree of @DISEASE$ if they express two copies of @GENE$*3.	[ "1" ]
589	589	@GENE$ genotypes in THBS-1 gene G1678A polymorphism may be a genetic risk factor of @DISEASE$ in Chinese population.	[ "0" ]
590	590	Thus, @GENE$ polymorphism is a genetic modifier for susceptibility and @DISEASE$ of MS in the central Ohio cohort that we studied, perhaps by affecting the efficiency of CD24 expression on the cell surface.	[ "0" ]
591	591	Our data support @GENE$/CP2/LSF as a candidate gene/risk factor for @DISEASE$ and provide justification for future studies to investigate the role of this gene in Alzheimer's disease.	[ "1" ]
592	592	We could not replicate that @GENE$ is a relevant @DISEASE$ susceptibility gene for IBD in German or Hungarian subjects.	[ "0" ]
593	593	No association was found between uterine @DISEASE$ and any polymorphisms in the AHRR, AHR, ARNT, or @GENE$ genes analyzed in the present study.	[ "1" ]
594	594	This study indicates that @GENE$ polymorphisms, in particular the GSTM1/GSTT1 double-null haplotype, can be considered low-penetrance genes for @DISEASE$.	[ "0" ]
595	595	Our results do not confirm the association of @GENE$ polymorphism (promoter -159 C to T transition) with @DISEASE$ in Polish children.	[ "1" ]
596	596	None of the SNPs of KCNQ1 P448R, KCNQ1 R519H, @GENE$ G643S, KCNE1 G38S and KCNE1 D85N was associated with @DISEASE$ phenotype, but KCNE4 E145D may relation to atrial fibrillation.	[ "1" ]
597	597	Our findings suggest that the genotype of Arg389Gly polymorphism in the human @GENE$ gene is associated with @DISEASE$.	[ "1" ]
598	598	In conclusion, a significant association between @DISEASE$ and @GENE$ T51C polymorphism localized on chromosome 3p21 was found.	[ "1" ]
599	599	The results suggest an important association between the MM genotype of Val-81-Met @GENE$ gene polymorphism and increased LV @DISEASE$ dimension and mass in a young normotensive male population, indicating an important role for genetic determination of the sympathetic system in LV growth.	[ "0" ]

500

The use of endophenotypic markers for @DISEASE$ such as the mood response to @GENE$ depletion may facilitate studies of complex genetic traits such as depression by decreasing its heterogeneity.

[ "0" ]

501

These data suggest that the @GENE$(*)1B is associated with smoking @DISEASE$ in white and intermediate, but not black Brazilians.

[ "0" ]

502

These results suggest that TCF7L2 variants may act through @GENE$ secretion to increase the risk of @DISEASE$.

[ "0" ]

503

These results provide substantial evidence that genetic variation within or extremely close to @GENE$ impacts both disease risk and traits related to the severity of @DISEASE$.

[ "1" ]

504

Our results suggest that the COX-2 Val511Ala SNP does not antagonize the effect of NSAIDs on colon cancer risk and provides support that NSAID use and the @GENE$ Val511Ala SNP may contribute to a reduced risk of @DISEASE$ among African Americans.

[ "1" ]

505

A genetic variant in @GENE$ was consistently associated with knee @DISEASE$ in 3 samples from 2 populations.

[ "1" ]

506

The risk of @DISEASE$ is not strongly associated with the I105V and A114V polymorphisms in the GSTP1 gene or with @GENE$ intron 6 polymorphism.

[ "1" ]

507

Our findings suggest that the C19007T @GENE$ polymorphism is unlikely to play an important role in epithelial ovarian or @DISEASE$ in Korean women.

[ "0" ]

508

The presence of the Asp299Gly allele of the @GENE$ gene does not seem to exert a major influence on the progression of @DISEASE$ in patients with FH.

[ "1" ]

509

These findings suggest that the @GENE$ 838G/A and GMNN 387C/A polymorphisms may not play a major role in the etiology of @DISEASE$, but CDT1 variant may have a potential role only in genetically susceptible women.

[ "1" ]

510

Our data suggest that genetic variation in the @GENE$ gene may modify the risk of @DISEASE$ in an APOE*4-dependent fashion.

[ "1" ]

511

Although there is a tendency of higher diastolic blood pressure in men with DD genotypes, there is no convincing evidence that @GENE$ genotypes are associated with @DISEASE$ in this Japanese population.

[ "1" ]

512

Two novel mutations in @GENE$ may be mutations characterized to @DISEASE$ of Chinese Shanghai population.

[ "0" ]

513

Individuals with less active @GENE$-uVNTR alleles may be at increased risk for @DISEASE$ and poor sleep.

[ "0" ]

514

Our results suggest that an interaction between COMT and @GENE$ genotypes may predict the treatment response to typical neuroleptics in patients with @DISEASE$.

[ "1" ]

515

linkage of the human @GENE$ gene to IDDM in a subset of patients supports a pathogenic role of nitric oxide in human @DISEASE$.

[ "1" ]

516

Our data do not support a significant genetic contribution of @GENE$ polymorphisms and haplotypes to affective psychosis, and the findings are inconclusive regarding their contribution to @DISEASE$-related traits.

[ "0" ]

517

These data, showing for the first time that @GENE$ polymorphism mediates susceptibility, are compatible with reports showing that PTCH @DISEASE$ influences development of BCC precursor lesions.

[ "0" ]

518

These data support a role for @GENE$ in the @DISEASE$ of ARDS and its associated physiological derangement.

[ "0" ]

519

Although these data do not preclude the possibility of an increased risk of @DISEASE$ in association with the Cowden syndrome, they indicate that germline @GENE$ mutations do not account for a significant proportion of genetic attributable risk for endometrial carcinoma.

[ "1" ]

520

The Trp64Arg @DISEASE$ of the @GENE$-adr gene may predict the result of dietary intervention in obese children to some extent, but it was not a major factor affecting weight in Chinese children.

[ "0" ]

521

These results indicated that G-33A polymorphism in @GENE$ might be a genetic risk factor for @DISEASE$.

[ "1" ]

522

our data suggests that the @GENE$ D allele is a modest risk factor for late-onset sporadic AD in Koreans, and the @DISEASE$ risk conferred by the A2M D allele increases in APOE epsilon4 negative subjects.

[ "1" ]

523

The eNOS G894T or eNOS 894TT genotypes in combination with the MTHFR 677TT or @GENE$ D/D genotype increases the risk of @DISEASE$.

[ "1" ]

524

The results seem to reflect a different susceptibility of MMP-2 as well as of some associated @GENE$ and ET-1 genotypes to @DISEASE$.

[ "1" ]

525

The data are compatible with certain missense mutations in @GENE$ predisposing to @DISEASE$.

[ "1" ]

526

The IVS1a+465C allele of the @GENE$ gene, which reduces expression of the gene, is a risk factor for @DISEASE$, especially the paranoid subtype.

[ "1" ]

527

These studies support that MEF2A mutations are not a common cause of CAD in white people and argue strongly against a role for the @GENE$ 21-bp deletion in autosomal dominant @DISEASE$.

[ "1" ]

528

We conclude that the @GENE$ polymorphism is unlikely to be a major risk factor in the @DISEASE$ of these major psychiatric disorders although there could be a small effect in schizophrenia.

[ "0" ]

529

This case-control study showed no significant association between @GENE$ gene polymorphisms and the risk of young-onset prostate cancer, suggesting that genetic variations in OBR are unlikely to have a major role in the development of early-onset @DISEASE$ in the UK.

[ "1" ]

530

These data suggest that the @GENE$ 469KK genotype could be a genetic risk factor for retinopathy in @DISEASE$.

[ "1" ]

531

In this study of @DISEASE$ patients, SCD was not related to polymorphisms in the @GENE$ gene.

[ "1" ]

532

These data highlight the crucial role of @GENE$ in the clinical outcome of @DISEASE$, as it has recently been shown that the mannose binding lectin gene is a modulating gene of the respiratory involvement in cystic fibrosis patients.

[ "0" ]

533

The results suggest that the BDNF C-270T polymorphism is a relevant risk factor for @DISEASE$ particularly in patients lacking the @GENE$ epsilon4 allele in this German sample.

[ "1" ]

534

These results suggest that apoE and @GENE$ may be part of a complex mechanism in the pathogenesis of @DISEASE$.

[ "1" ]

535

A significant portion of @DISEASE$ is associated with @GENE$ epsilon4 in the general population.

[ "1" ]

536

The results suggested that the T(-344)C polymorphism of @GENE$ gene may be associated with @DISEASE$ in female Kazakh population of Xinjiang Barlikun area.

[ "1" ]

537

These results do not support the hypothesis that @GENE$ L10P genotypes modify the risk of breast cancer in BRCA1 or @DISEASE$ carriers.

[ "0" ]

538

These findings suggest a role for the @GENE$ gene in @DISEASE$ susceptibility and imply that this role may be realized at least in part by the induction of increases in hK2 production.

[ "1" ]

539

Our results suggest that @GENE$, COMT, 5-HT2A, DRD2, and DRD4 gene variants are not involved in susceptibility toward different time courses in @DISEASE$.

[ "1" ]

540

The TF @GENE$ variant did not confer a risk for @DISEASE$ in Koreans.

[ "0" ]

541

Our data therefore suggests that the @GENE$ and A2aAR genes do not play major roles in the development of this @DISEASE$.

[ "0" ]

542

Sequence variants at the @GENE$ genomic locus may influence risk of @DISEASE$ in humans.

[ "1" ]

543

Our data suggest both TNF and @GENE$ genes are not major susceptibility genes for @DISEASE$.

[ "0" ]

544

The present study demonstrates that the CC genotype of the -634 C/G @GENE$ gene might be a risk factor for @DISEASE$ in Caucasians with type 2 diabetes of duration of more than 10 years.

[ "1" ]

545

Based on statistical analysis homozygosity for nonconservative mutations in the coding region of the @GENE$ gene is estimated @DISEASE$/300 000 when a white Caucasian population is considered, arguing against an important role of mutations of this coding region in hypertension and hypertension-associated progression of renal disease.

[ "0" ]

546

The rs1800947 SNP and the C-C-C haplotype in the @GENE$ gene appear to be prognostic markers of @DISEASE$ and this polymorphism could be a useful genetic marker.

[ "1" ]

547

Findings from this general population sample could not confirm the hypothesis that @GENE$ moderates the relationship between adolescent maltreatment and adolescent or @DISEASE$.

[ "0" ]

548

Genotype for @GENE$ may prove reliable for assessment of genetic risk for @DISEASE$.

[ "1" ]

549

Results do not support any overall association of the Ala-9Val @GENE$ polymorphism to the development of @DISEASE$.

[ "1" ]

550

These results suggested that the variant might act as a functional genetic factor of @DISEASE$ with a unique mechanism to upregulate local and systemic @GENE$ concentration in vivo.

[ "1" ]

551

The @GENE$ promoter genotype that controls the degree of HO-1 up-regulation in response to stress stimuli is associated with the postintervention @DISEASE$ and the restenosis risk after balloon angioplasty.

[ "0" ]

552

Our results suggest that @GENE$ genetic variations do not appear to be major determinants for @DISEASE$ susceptibility in the Taiwanese population.

[ "1" ]

553

In conclusion, our results do not support the hypothesis of an important role of common genetic variation in @GENE$ for the development of @DISEASE$ in our sample.

[ "1" ]

554

The observation of frequency differences between cases and controls in two independent samples strongly suggests that the @GENE$ gene is involved as a risk factor for developing @DISEASE$ at a young age, but the identified polymorphisms are probably acting as markers for an unidentified functional mutation elsewhere in the gene locus.

[ "1" ]

555

The common @GENE$ allelic variant was associated with increased @DISEASE$ survival and with reduced tumor infiltration by microglia.

[ "0" ]

556

These results do not support the hypothesis that @GENE$ L10P genotypes modify the risk of @DISEASE$ in BRCA1 or BRCA2 mutation carriers.

[ "1" ]

557

Our studies suggest that a T-to-C substitution at -586 of the @GENE$ promoter is associated with a lowered @DISEASE$ activity and that this variation may contribute to the increased plasma HDL-C concentration in the Chinese.

[ "0" ]

558

Polymorphisms of @GENE$ and CCR5 do not seem to be involved in susceptibility to @DISEASE$, although a slight contribution of the CCR5 polymorphism in the production of anti-dsDNA autoantibodies, in the development of lupus nephritis, and in the outcome of the disease could be postulated.

[ "0" ]

559

no association between @GENE$ T98P genotype and the phenotype of the benign or @DISEASE$ was observed.

[ "1" ]

560

Thus, the present study provided no evidence for statistically significant associations between the @GENE$ polymorphisms and the @DISEASE$ traits.

[ "0" ]

561

These results support the hypothesis that these @GENE$ mutations represent major gene effects for @DISEASE$.

[ "1" ]

562

These findings indicate that in patients without a clinical diagnosis of CF, @GENE$ gene mutations could be involved in the development of @DISEASE$, in association with other genetic or environmental factors.

[ "1" ]

563

@GENE$, II genotype carrier females may have increased risk for @DISEASE$.

[ "0" ]

564

These associations suggest that the @GENE$ region also determines susceptibility to spinal disc degeneration and CMC1 @DISEASE$.

[ "1" ]

565

These observations suggest that lower expression of UGT1A1 decreases the risk of @DISEASE$ by reducing the excretion of 2-hydroxyestradiol, the antiproliferative metabolite of @GENE$), in the endometrium.

[ "0" ]

566

Although there was little statistical power to detect modest increases in risk for the homozygote variant genotypes, particularly for the rare @GENE$ and XRCC2 variants, the data suggest that none of these variants play a major role in the etiology of breast or @DISEASE$.

[ "0" ]

567

Combining the two 'candidate' SNPs (P187S and R72P) revealed an increased risk for @DISEASE$ of double heterozygotes (P187S/R72P) of the @GENE$ and TP53 genes (OR=1.88; 95% CI 1.13-3.15; P=0.011), suggesting a possible interaction of these two loci.

[ "1" ]

568

The CYP1A1 Ile-Val gene polymorphisms might be associated with the occurrence of @DISEASE$, while MspI gene polymorphisms and @GENE$ slow acetylator genotype might not be associated with the occurrence of prostate cancer.

[ "1" ]

569

This study provides insights into the genetic @DISEASE$ of @GENE$.

[ "0" ]

570

Thus, in addition to the antigen-driven excess Th2 response, increased T-bet (and subsequent @GENE$) production in human airways of individuals with the -1993T-->C polymorphism could contribute to the development of certain @DISEASE$-related phenotypes, such as AIA.

[ "0" ]

571

the data indicates the G allele of MDM2 SNP309 might have a protective effect on disease development in HNPCC patients and that age of diagnosis of @DISEASE$ is not associated with @GENE$ SNP309 or TP53 R72P either as single SNPs or combined.

[ "1" ]

572

we have found evidence that a single tagged SNP in both the CDKN2A and @GENE$ genes may be associated with reduced @DISEASE$ risk.

[ "1" ]

573

Although the @GENE$*08-DQA1*0401-DQB1*04 haplotype was significantly associated with @DISEASE$, consistent with other studies, this haplotype nevertheless represented only 19% (14/72) of all PBC patients and can account for only a minority of the risk of PBC.

[ "0" ]

574

The @DISEASE$ of this polymorphism, the small sample size and the heterogeneous ethnic backgrounds of participants in the @GENE$ study allow only tentative conclusions based on the results, thus the role of the opioid receptor in pain and opioid reward response remains uncertain.

[ "0" ]

575

7216A/G polymorphism of @GENE$ gene may be one of the genetic factors that determine the presence of anti-@DISEASE$-A/Ro52 antibody in patients with primary SS.

[ "0" ]

576

A panel of thrombogenic gene mutations consisting of factor V G1691A, factor V H1299R (@GENE$), factor II prothrombin G20210A, factor XIII V34L, beta-fibrinogen -455G>A, PAI-1 4G/5G, HPA1 a/b(L33P), MTHFR C677T, and MTHFR A1298C can identify individuals at risk for @DISEASE$.

[ "0" ]

577

The SNP021 in the gene @GENE$ is associated with @DISEASE$ of Chinese Han population in Shanghai and the role of SCN7A gene in hypertension deserves to be further analyzed.

[ "0" ]

578

It is unlikely that the @GENE$ gene is a locus responsible for @DISEASE$.

[ "1" ]

579

Tunisian persons carrying the @GENE$ A1/A3 genotype may have an increased risk of severe @DISEASE$.

[ "0" ]

580

We find no evidence to support an association between @GENE$ genotype and either the diagnosis of idiopathic dilated cardiomyopathy itself or @DISEASE$ of the disease.

[ "0" ]

581

Our data showed that the APOE epsilon4 allele frequency in AD was significantly higher than that in the normal controls (chi2 = 11.66, P < 0.01) neither the frequencies of genotypes nor alleles of the TNF alpha-308 A/G and @GENE$ polymorphisms were significantly different between @DISEASE$ and controls,suggesting the two polymorphisms were not risk factors to LOAD in Chinese.

[ "1" ]

582

our data suggest that GST and @GENE$ genotypes are not associated with the susceptibility to @DISEASE$ or its outcome in the Brazilian population.

[ "1" ]

583

The present study indicated the @GENE$ B haplotype as a putative risk factor for @DISEASE$ in PGRN mutations negative patients.

[ "1" ]

584

This is the first study to report a significant association between the @GENE$ gene and @DISEASE$.

[ "0" ]

585

We conclude that in @GENE$*3-Leiden allele carriers FD is dominantly inherited with a high rate of penetrance, i.e., the presence of normally functioning apoE molecules in the plasma does not prevent the age-related expression of this @DISEASE$.

[ "0" ]

586

Homozygosity for the T677 allele of the @GENE$ gene, although slightly more prevalent in patients compared to controls, has not been found in association with @DISEASE$.

[ "1" ]

587

These results suggest that @GENE$ might play a role in genetic susceptibility to @DISEASE$.

[ "1" ]

588

The study demonstrates that patients who develop myalgia while taking atorvastatin are more likely to experience a greater degree of @DISEASE$ if they express two copies of @GENE$*3.

[ "1" ]

589

@GENE$ genotypes in THBS-1 gene G1678A polymorphism may be a genetic risk factor of @DISEASE$ in Chinese population.

[ "0" ]

590

Thus, @GENE$ polymorphism is a genetic modifier for susceptibility and @DISEASE$ of MS in the central Ohio cohort that we studied, perhaps by affecting the efficiency of CD24 expression on the cell surface.

[ "0" ]

591

Our data support @GENE$/CP2/LSF as a candidate gene/risk factor for @DISEASE$ and provide justification for future studies to investigate the role of this gene in Alzheimer's disease.

[ "1" ]

592

We could not replicate that @GENE$ is a relevant @DISEASE$ susceptibility gene for IBD in German or Hungarian subjects.

[ "0" ]

593

No association was found between uterine @DISEASE$ and any polymorphisms in the AHRR, AHR, ARNT, or @GENE$ genes analyzed in the present study.

[ "1" ]

594

This study indicates that @GENE$ polymorphisms, in particular the GSTM1/GSTT1 double-null haplotype, can be considered low-penetrance genes for @DISEASE$.

[ "0" ]

595

Our results do not confirm the association of @GENE$ polymorphism (promoter -159 C to T transition) with @DISEASE$ in Polish children.

[ "1" ]

596

None of the SNPs of KCNQ1 P448R, KCNQ1 R519H, @GENE$ G643S, KCNE1 G38S and KCNE1 D85N was associated with @DISEASE$ phenotype, but KCNE4 E145D may relation to atrial fibrillation.

[ "1" ]

597

Our findings suggest that the genotype of Arg389Gly polymorphism in the human @GENE$ gene is associated with @DISEASE$.

[ "1" ]

598

In conclusion, a significant association between @DISEASE$ and @GENE$ T51C polymorphism localized on chromosome 3p21 was found.

[ "1" ]

599

The results suggest an important association between the MM genotype of Val-81-Met @GENE$ gene polymorphism and increased LV @DISEASE$ dimension and mass in a young normotensive male population, indicating an important role for genetic determination of the sympathetic system in LV growth.

[ "0" ]