bigbio/gad · Datasets at Hugging Face

id stringlengths 1 4	document_id stringlengths 1 4	text stringlengths 42 538	labels list
400	400	Although there are limitations for interpretation of this study because of prevalent case-control study and partial statistical significance, these results suggest that @GENE$ -463 A allele reduce the risk of @DISEASE$.	[ "1" ]
401	401	To our knowledge, this is the first report to detect associations between @GENE$ genetic variants and @DISEASE$ pressure.	[ "0" ]
402	402	The present study shows that R219K polymorphism of @GENE$ gene and G > C polymorphism in intron 7 of PPARA gene act cumulatively and synergistically in determining the risk of premature @DISEASE$.	[ "1" ]
403	403	@GENE$ @DISEASE$ is associated with ASCA positivity not only in patients with CD, but also in their relatives.	[ "0" ]
404	404	Our data indicate that the -160 single nucleotide polymorphism in @GENE$ is a low-penetrant prostate cancer susceptibility gene that might explain a proportion of familial and notably @DISEASE$.	[ "0" ]
405	405	These findings suggest that individual susceptibility of @DISEASE$ may be modulated by MPO and @GENE$ polymorphisms, and that the combination of genetic factors involved in oxidative stress response with environmental carcinogens may play an important role in bladder carcinogenesis.	[ "1" ]
406	406	It is unlikely that CYP17 @GENE$-34T>C has a role in @DISEASE$ etiology, overall or in combination with established non-genetic breast cancer risk factors.	[ "0" ]
407	407	Infant PON1 RR and @GENE$ CC genotypes were associated with @DISEASE$ in our study population, which suggests a possible role for human paraoxonase variability in the etiology of preterm delivery.	[ "1" ]
408	408	We conclude that the prevalence of FDB in our ethnically diverse population is lower than that reported in previous studies of predominantly Caucasian populations and that the Chinese subject represents either an independent @DISEASE$ or possibly recombination at the 3' end of the @GENE$ gene, an event not previously described.	[ "0" ]
409	409	In conclusion, this study revealed a strong association between @GENE$ gene polymorphisms and serum P-selectin levels and a complex age-dependent relation between soluble P-selectin levels and @DISEASE$, which suggests that this molecule might have different roles in the atherothrombotic process.	[ "1" ]
410	410	The combined ThrThr/TT haplotype of GPIbalpha as well as the @GENE$ genotype of GPIV seem to decrease the risk of fatal @DISEASE$ among men during early middle-age.	[ "0" ]
411	411	These results confirm that the (TA)7/(TA)7 @GENE$ genotype is one of the factors accounting for the @DISEASE$ observed in beta-thalassemia major, intermedia, and heterozygous individuals.	[ "0" ]
412	412	It does not appear that this common variant of @GENE$, a T to C substitution in the 5' promoter region, plays a significant role in the adrenal @DISEASE$ of PCOS.	[ "0" ]
413	413	We conclude that -1989T/G or its linked polymorphisms in the @GENE$ gene may confer risk for @DISEASE$ and that the G/G genotype may be an independent predictor for CAD in patients with familial hypercholesterolemia.	[ "1" ]
414	414	Our findings suggest that the A-G polymorphism of @GENE$ may confer susceptibility to suicide behavior in @DISEASE$ patients.	[ "0" ]
415	415	This is the first report to implicate @GENE$ in a human @DISEASE$ of energy metabolism, Type 2 diabetes.	[ "0" ]
416	416	Our results suggest that the @GENE$ polymorphism may have a significant influence on the development of advanced and/or high grade prostate cancer and the absence of the CYP11A1 (tttta)4 allele, i.e., the homozygosity for the (tttta)6 or longer allele, could be a useful marker for the prediction of disease progression of @DISEASE$.	[ "1" ]
417	417	Results from this first study of @GENE$ genotypes and breast cancer risk indicate that MPO variants, related to reduced generation of ROS, are associated with decreased breast cancer risk, and emphasize the importance of fruit and vegetable consumption in reduction of @DISEASE$ risk.	[ "1" ]
418	418	In this study low levels of alcohol are associated with a modest increase in @DISEASE$ risk that is not altered by known functional allelic variants of the @GENE$ and 1C gene.	[ "1" ]
419	419	@GENE$ may be an important @DISEASE$ gene.	[ "1" ]
420	420	Our data suggest that the @GENE$ -374T/A polymorphism is one of the likely candidate determinants for the genetic variance of disease phenotype in @DISEASE$.	[ "1" ]
421	421	The current study does not support the notion that the polymorphism in the @GENE$ gene constitutes a risk factor for either late-onset or early-onset AD, which means that other genetic factors play a role in the development of @DISEASE$ in the Italian population.	[ "1" ]
422	422	@GENE$ 936 C/C genotype or C allele is not related to the development of colorectal cancer, but they can reduce the risk of anastomotic leakage after surgery in @DISEASE$ patients.	[ "1" ]
423	423	These findings provide suggestive evidence of association of the @GENE$ gene locus with @DISEASE$ in northern and northwestern Indian populations.	[ "0" ]
424	424	We conclude that a common variation (Thr230Met) in the @GENE$ gene is associated with a marked increase in beta2-adrenoceptor sensitivity in subcutaneous fat cells, which may be of importance in @DISEASE$ regulation.	[ "0" ]
425	425	Our study suggests that a genetically determined exposure to relatively low @GENE$ levels is associated with an increased risk for @DISEASE$ and myocardial infarction.	[ "1" ]
426	426	Most patients with @DISEASE$, in addition to their reduced B-@GENE$ enzyme activity, may have abnormalities in the glucuronidation of aspirin or coumarin- and dopamine-derivatives, due to this combination of UGT1A128 and UGT1A62 genotypes.	[ "0" ]
427	427	These data indicate that @GENE$ is an influential gene in @DISEASE$ and glucose intolerance in this population, whereas gene-based haplotypes of IRS2 have revealed heterogeneity in the behaviour of the Gly1057Asp mutation in relation to insulin resistance.	[ "0" ]
428	428	This study establishes the first mutational report of the @GENE$ gene in correlation with @DISEASE$.	[ "0" ]
429	429	In conclusion, the @GENE$-L162V polymorphism alone or in interaction with dietary fat intake is associated with components of the @DISEASE$.	[ "1" ]
430	430	Study results do not demonstrate an association between @GENE$ ID polymorphism and @DISEASE$ in our patients.	[ "1" ]
431	431	These results suggest that the UGT2B17 enzyme may play a role in the metabolism of androgens in prostate tissue and that the @GENE$ deletion polymorphism is associated with @DISEASE$ risk.	[ "1" ]
432	432	It was suggested that @GENE$ gene C677T mutation was a possible risk factor of Chinese premature @DISEASE$.	[ "1" ]
433	433	@GENE$ and MMP-3 promoter polymorphism is not associated with the susceptibility to @DISEASE$.	[ "1" ]
434	434	These data together with recent functional data on the direct effect of @GENE$ on blood pressure suggest that the leptin gene and its product, leptin, are an attractive target for studies on the mechanisms of @DISEASE$ and for the development of methods for the prediction, prevention, and therapy for hypertension.	[ "1" ]
435	435	Therefore, -344C/T polymorphism in @GENE$ was considered an independent genetic factor possibly associated with @DISEASE$ or atherosclerotic diseases in the Japanese population.	[ "0" ]
436	436	These results suggest that the @GENE$ gene region on chromosome 2q33 is a susceptibility locus for @DISEASE$ in the United Kingdom.	[ "1" ]
437	437	We conclude that the association of the @GENE$ intron 13 polymorphism with @DISEASE$, if any, is smaller than previously reported.	[ "1" ]
438	438	In conclusion, a significant association between @DISEASE$ and @GENE$ T51C polymorphism localized on chromosome 3p21 was found.	[ "1" ]
439	439	The D76N variant of @GENE$ does not significantly alter insulin secretion or act as a high-risk susceptibility allele for late-onset @DISEASE$ as proposed previously, although we cannot exclude a minor role in increasing risk of diabetes.	[ "1" ]
440	440	polymorphisms of @GENE$ and @DISEASE$ associate with type II diabetes and estimates of insulin resistance in Danish white subjects.	[ "0" ]
441	441	Results in the present study suggested that there was a coordinated effect between @GENE$ 1298 genotypes and habits of smoking, alcohol drinking and tea @DISEASE$ in the development of EC.	[ "0" ]
442	442	Our results suggest that the CYP11A1 polymorphism may have a significant influence on the development of advanced and/or high grade prostate cancer and the absence of the @GENE$ (tttta)4 allele, i.e., the homozygosity for the (tttta)6 or longer allele, could be a useful marker for the prediction of disease progression of @DISEASE$.	[ "1" ]
443	443	These findings in a large, well characterized asthma population, reveal that, while FLAP is an important enzyme in cys-LTs biosynthesis, polymorphisms in the @GENE$ gene are not likely to be functionally associated with the @DISEASE$ phenotype.	[ "1" ]
444	444	Homozygosity for the 5G allele of the @GENE$ gene is associated with normal glucose @DISEASE$ in pregnant women.	[ "0" ]
445	445	A significant association between @DISEASE$-1 infection and the presence of an allelic variant was observed in the case of the M2 and A332A haplotypes, thus presenting @GENE$ as a potentially novel HIV-1 susceptibility locus.	[ "1" ]
446	446	The @GENE$ 49 Ala allele confers an increased risk of @DISEASE$, independent of age and HLA-DQ genetic markers.	[ "1" ]
447	447	it is likely that PPARalpha gene does not have a major role in diabetes and @DISEASE$ in our populations, although we can not exclude a minor contribution of the @GENE$ gene to the risk of CHD associated with Type 2 diabetes through a modulation of atherogenic plasma lipids.	[ "1" ]
448	448	Our study provides the first evidence that @GENE$ polymorphism participates in the development of THS, and sheds light on the genetic causes of this @DISEASE$ and genetic differences between tamoxifen-treated individuals.	[ "0" ]
449	449	AACT * A6 allele may be associated with @DISEASE$ negatively in Shanghai area, and this effect only exists in non-@GENE$ * epsilon 4 AD.	[ "1" ]
450	450	We conclude that I/D-@GENE$ gene polymorphism has no important effect on susceptibility to @DISEASE$ or HAPE.	[ "0" ]
451	451	Given the lines of evidence from different genetic studies, we suggest that TNFalpha may play a role in @DISEASE$ of @GENE$.	[ "0" ]
452	452	Our study suggests for the first time that @GENE$ polymorphisms are associated with @DISEASE$.	[ "0" ]
453	453	Our results suggest an important role for @GENE$ in @DISEASE$ in women and also raise the possibility that previously proposed disease-associated SNPs in the HTR3A/B region in Caucasians are in linkage disequilibrium with haplotype block 2 of HTR3B in the Japanese.	[ "1" ]
454	454	Therefore, we show associations between Glu allele of @GENE$ (Glu298Asp) and @DISEASE$ and between 4a allele (ecNOS4a/4b) and diastolic dysfunction in patients with essential hypertension.	[ "0" ]
455	455	The results do not indicate that any of the three SNPs studied are associated with @DISEASE$, @GENE$ measures or lipid measures.	[ "0" ]
456	456	We propose that although mutations in @GENE$ and GDF9 are not a major cause of ovarian insufficiency, they may be involved in @DISEASE$.	[ "1" ]
457	457	These data therefore confirm the importance of SLC11A1 in tuberculosis susceptibility in humans and suggest that @GENE$ influences @DISEASE$ susceptibility by regulation of interleukin-10.	[ "1" ]
458	458	The polymorphisms of @GENE$ and p21 were significantly associated with the occurrence of smoking-related @DISEASE$ in Taiwan Chinese patients.	[ "1" ]
459	459	The urokinase @GENE$ activator (BamHI) and plasminogen activator inhibitor type 1 (HindIII) genotypes may serve as useful markers for heritability of @DISEASE$ associated with periodontal disease.	[ "0" ]
460	460	Our @DISEASE$ further supports the hypothesis that the shorter CAG repeat length of the @GENE$ gene is related to prostate enlargement.	[ "0" ]
461	461	Data from this study do not support a strong role for the @GENE$ Met98Lys variant in @DISEASE$, ADOA or LHON.	[ "0" ]
462	462	We found evidence that a SNP in @GENE$ is modestly associated with @DISEASE$ in whites from the ARIC study and the WGHS.	[ "1" ]
463	463	Genetic variation in @GENE$ may affect susceptibility to and increase risk for @DISEASE$ in Taiwanese aboriginals.	[ "1" ]
464	464	Although mutations in regulatory elements affecting gene function cannot be excluded, the @GENE$ gene does not seem to have a major role in primary @DISEASE$ in humans.	[ "1" ]
465	465	Our findings support the hypothesis that the @GENE$ gene participates in the etiopathogenesis of @DISEASE$.	[ "0" ]
466	466	Our findings support the hypothesis that @DISEASE$- and depression-related personality @GENE$ are associated with the BDNF polymorphism although the explained variance is low.	[ "0" ]
467	467	We conclude that variability at the @GENE$ locus is associated with obesity and other features of the @DISEASE$, but given the nature of the two SNPs, the risk haplotype is most probably a marker in linkage disequilibrium with an as yet unidentified polymorphism that affects plasma adiponectin levels and insulin sensitivity.	[ "0" ]
468	468	These findings suggest that apoD may be related to the cognitive decline observed in AD patients and that @GENE$ and apoE likely play different roles in the pathogenesis of @DISEASE$.	[ "1" ]
469	469	The @GENE$ 5A/6A promoter polymorphism does not appear to influence breast cancer susceptibility but may be linked to a higher risk for metastasizing among @DISEASE$ patients.	[ "1" ]
470	470	In conclusion, we have replicated the association of the HNF4alpha @GENE$ promoter haplotype with @DISEASE$ in a U.K. Caucasian population where there is no evidence of linkage to 20q.	[ "0" ]
471	471	The difference in phenotypes between the two related heterozygotes, and the observation of obesity in other family members without the mutation suggests that @DISEASE$ results from a varying combination of environmental, behavioural and multiple genetic factors (other than @GENE$), even within the same family.	[ "1" ]
472	472	@GENE$ is a major gene for @DISEASE$ but not hyperuricemia in Japanese.	[ "0" ]
473	473	Our data support the hypothesis that -463A polymorphism in the @GENE$ gene may reduce the susceptibility to @DISEASE$ in the Chinese.	[ "1" ]
474	474	These results indicate that @DISEASE$ with C pneumoniae leads mainly to the development and progression of severe @GENE$ in patients with variation in the MBL gene.	[ "0" ]
475	475	We found no evidence to suggest that BRAF is a low-risk @GENE$ @DISEASE$ susceptibility gene.	[ "0" ]
476	476	Thus, our analyses of the genetic variations of the @GENE$ gene suggest that, at least in French Caucasians, they do not represent a major cause of @DISEASE$.	[ "1" ]
477	477	We identify the significant association of the @GENE$*3 allele encoding a low catalytic activity protein as a risk gene in proximal digestive tract @DISEASE$ and as a potential marker for cancer susceptibility.	[ "0" ]
478	478	These results suggest that @GENE$ promoter polymorphisms may contribute, at least partially, to host antiviral activity for @DISEASE$.	[ "1" ]
479	479	Genetic variations in ADIPOR1 or @GENE$ are unlikely to lead to a common genetic predisposition to insulin resistance or @DISEASE$ in the Japanese population.	[ "1" ]
480	480	These results indicate that @GENE$ sequence variants are associated with a small increase in the risk of developing UC and may influence @DISEASE$ behavior.	[ "0" ]
481	481	Thus, the @GENE$ exon 1 polymorphism may represent a susceptibility marker for @DISEASE$ progression in diabetic patients.	[ "0" ]
482	482	The @GENE$ Trp719Arg polymorphism was not associated with the risk of clinical @DISEASE$ in this large replication study.	[ "1" ]
483	483	The @GENE$ genotype may have an independent association with @DISEASE$, although our evidence did not show statistical significance.	[ "0" ]
484	484	The @DISEASE$ mutation in exon 11 in @GENE$ gene may be related to CAD susceptibility in the Chinese population.	[ "0" ]
485	485	The insertion of the guanine in the promoter of the @GENE$ gene does not appear to increase the risk of development of pregnancy-induced hypertension, @DISEASE$.	[ "0" ]
486	486	Our results suggest that the @GENE$ 4G/5G promoter polymorphism is not associated CVD risk factors or incident @DISEASE$ events in the elderly.	[ "1" ]
487	487	The 363S allele of the N363S variant of @GENE$ is associated with the susceptibility to overweight in subjects with @DISEASE$.	[ "1" ]
488	488	We did not confirm the previously reported association of this @GENE$ polymorphism with @DISEASE$ in our UK population despite its ethnic similarities with the Swedish population in which it was first described.	[ "1" ]
489	489	These data provide a plausible biological explanation for the reduced risk for @DISEASE$ as observed in @GENE$ -463AA/AG compared with MPO -463GG subjects.	[ "0" ]
490	490	In conclusion, none of the polymorphisms were found to play a key role in the @GENE$ inducibility or in the susceptibility to develop @DISEASE$.	[ "0" ]
491	491	Our study indicates that the V418M polymorphism of @GENE$ contributes to the genetic regulation of femoral neck BMD in women and adds to accumulating evidence that indicates that subtle polymorphic variation in genes that cause monogenic @DISEASE$ also contribute to regulation of BMD in normal subjects.	[ "0" ]
492	492	Our results indicate a role of the @GENE$ gene in genetic predisposition of @DISEASE$ such as obesity, type 2 diabetes, and dyslipidemia.	[ "0" ]
493	493	IVS14A and 451Q @DISEASE$ of @GENE$ gene were rare in Chinese population and 442G mutant gene was possibly one of the susceptibility factors to CHD in Chinese.	[ "0" ]
494	494	Our data suggest that the @GENE$ Y402H polymorphism is a major risk factor for exudative @DISEASE$ in a Central European population.	[ "1" ]
495	495	These data implicate ASCA as a specific marker of @DISEASE$ location and progression in @GENE$, emphasizing the heterogeneity within IBD.	[ "0" ]
496	496	The present study demonstrates that the AA genotype of the Gly482Ser polymorphism in the @GENE$ gene might be a risk factor for diabetic retinopathy in the Slovene population (Caucasians) with @DISEASE$ (odds ratio 2.7, 95% confidence interval 1.0-6.8), whereas the Pro12Ala polymorphism of the PPARgamma gene failed to confer susceptibility to diabetic retinopathy.	[ "1" ]
497	497	These results suggest that @GENE$+3953 allele 2 may be a risk indicator for the susceptibility to severe @DISEASE$ in Uighur minority in Xingjiang of China.	[ "0" ]
498	498	These findings suggest that @GENE$ may be related to the cognitive decline observed in @DISEASE$ patients and that apoD and apoE likely play different roles in the pathogenesis of AD.	[ "1" ]
499	499	In this study, the @GENE$ C1772T polymorphism does not appear to influence EPO, Sao2, or @DISEASE$ responses during acute hypoxic exposure, or the magnitude of the HVR.	[ "0" ]

400

Although there are limitations for interpretation of this study because of prevalent case-control study and partial statistical significance, these results suggest that @GENE$ -463 A allele reduce the risk of @DISEASE$.

[ "1" ]

401

To our knowledge, this is the first report to detect associations between @GENE$ genetic variants and @DISEASE$ pressure.

[ "0" ]

402

The present study shows that R219K polymorphism of @GENE$ gene and G > C polymorphism in intron 7 of PPARA gene act cumulatively and synergistically in determining the risk of premature @DISEASE$.

[ "1" ]

403

@GENE$ @DISEASE$ is associated with ASCA positivity not only in patients with CD, but also in their relatives.

[ "0" ]

404

Our data indicate that the -160 single nucleotide polymorphism in @GENE$ is a low-penetrant prostate cancer susceptibility gene that might explain a proportion of familial and notably @DISEASE$.

[ "0" ]

405

These findings suggest that individual susceptibility of @DISEASE$ may be modulated by MPO and @GENE$ polymorphisms, and that the combination of genetic factors involved in oxidative stress response with environmental carcinogens may play an important role in bladder carcinogenesis.

[ "1" ]

406

It is unlikely that CYP17 @GENE$-34T>C has a role in @DISEASE$ etiology, overall or in combination with established non-genetic breast cancer risk factors.

[ "0" ]

407

Infant PON1 RR and @GENE$ CC genotypes were associated with @DISEASE$ in our study population, which suggests a possible role for human paraoxonase variability in the etiology of preterm delivery.

[ "1" ]

408

We conclude that the prevalence of FDB in our ethnically diverse population is lower than that reported in previous studies of predominantly Caucasian populations and that the Chinese subject represents either an independent @DISEASE$ or possibly recombination at the 3' end of the @GENE$ gene, an event not previously described.

[ "0" ]

409

In conclusion, this study revealed a strong association between @GENE$ gene polymorphisms and serum P-selectin levels and a complex age-dependent relation between soluble P-selectin levels and @DISEASE$, which suggests that this molecule might have different roles in the atherothrombotic process.

[ "1" ]

410

The combined ThrThr/TT haplotype of GPIbalpha as well as the @GENE$ genotype of GPIV seem to decrease the risk of fatal @DISEASE$ among men during early middle-age.

[ "0" ]

411

These results confirm that the (TA)7/(TA)7 @GENE$ genotype is one of the factors accounting for the @DISEASE$ observed in beta-thalassemia major, intermedia, and heterozygous individuals.

[ "0" ]

412

It does not appear that this common variant of @GENE$, a T to C substitution in the 5' promoter region, plays a significant role in the adrenal @DISEASE$ of PCOS.

[ "0" ]

413

We conclude that -1989T/G or its linked polymorphisms in the @GENE$ gene may confer risk for @DISEASE$ and that the G/G genotype may be an independent predictor for CAD in patients with familial hypercholesterolemia.

[ "1" ]

414

Our findings suggest that the A-G polymorphism of @GENE$ may confer susceptibility to suicide behavior in @DISEASE$ patients.

[ "0" ]

415

This is the first report to implicate @GENE$ in a human @DISEASE$ of energy metabolism, Type 2 diabetes.

[ "0" ]

416

Our results suggest that the @GENE$ polymorphism may have a significant influence on the development of advanced and/or high grade prostate cancer and the absence of the CYP11A1 (tttta)4 allele, i.e., the homozygosity for the (tttta)6 or longer allele, could be a useful marker for the prediction of disease progression of @DISEASE$.

[ "1" ]

417

Results from this first study of @GENE$ genotypes and breast cancer risk indicate that MPO variants, related to reduced generation of ROS, are associated with decreased breast cancer risk, and emphasize the importance of fruit and vegetable consumption in reduction of @DISEASE$ risk.

[ "1" ]

418

In this study low levels of alcohol are associated with a modest increase in @DISEASE$ risk that is not altered by known functional allelic variants of the @GENE$ and 1C gene.

[ "1" ]

419

@GENE$ may be an important @DISEASE$ gene.

[ "1" ]

420

Our data suggest that the @GENE$ -374T/A polymorphism is one of the likely candidate determinants for the genetic variance of disease phenotype in @DISEASE$.

[ "1" ]

421

The current study does not support the notion that the polymorphism in the @GENE$ gene constitutes a risk factor for either late-onset or early-onset AD, which means that other genetic factors play a role in the development of @DISEASE$ in the Italian population.

[ "1" ]

422

@GENE$ 936 C/C genotype or C allele is not related to the development of colorectal cancer, but they can reduce the risk of anastomotic leakage after surgery in @DISEASE$ patients.

[ "1" ]

423

These findings provide suggestive evidence of association of the @GENE$ gene locus with @DISEASE$ in northern and northwestern Indian populations.

[ "0" ]

424

We conclude that a common variation (Thr230Met) in the @GENE$ gene is associated with a marked increase in beta2-adrenoceptor sensitivity in subcutaneous fat cells, which may be of importance in @DISEASE$ regulation.

[ "0" ]

425

Our study suggests that a genetically determined exposure to relatively low @GENE$ levels is associated with an increased risk for @DISEASE$ and myocardial infarction.

[ "1" ]

426

Most patients with @DISEASE$, in addition to their reduced B-@GENE$ enzyme activity, may have abnormalities in the glucuronidation of aspirin or coumarin- and dopamine-derivatives, due to this combination of UGT1A1*28 and UGT1A6*2 genotypes.

[ "0" ]

427

These data indicate that @GENE$ is an influential gene in @DISEASE$ and glucose intolerance in this population, whereas gene-based haplotypes of IRS2 have revealed heterogeneity in the behaviour of the Gly1057Asp mutation in relation to insulin resistance.

[ "0" ]

428

This study establishes the first mutational report of the @GENE$ gene in correlation with @DISEASE$.

[ "0" ]

429

In conclusion, the @GENE$-L162V polymorphism alone or in interaction with dietary fat intake is associated with components of the @DISEASE$.

[ "1" ]

430

Study results do not demonstrate an association between @GENE$ ID polymorphism and @DISEASE$ in our patients.

[ "1" ]

431

These results suggest that the UGT2B17 enzyme may play a role in the metabolism of androgens in prostate tissue and that the @GENE$ deletion polymorphism is associated with @DISEASE$ risk.

[ "1" ]

432

It was suggested that @GENE$ gene C677T mutation was a possible risk factor of Chinese premature @DISEASE$.

[ "1" ]

433

@GENE$ and MMP-3 promoter polymorphism is not associated with the susceptibility to @DISEASE$.

[ "1" ]

434

These data together with recent functional data on the direct effect of @GENE$ on blood pressure suggest that the leptin gene and its product, leptin, are an attractive target for studies on the mechanisms of @DISEASE$ and for the development of methods for the prediction, prevention, and therapy for hypertension.

[ "1" ]

435

Therefore, -344C/T polymorphism in @GENE$ was considered an independent genetic factor possibly associated with @DISEASE$ or atherosclerotic diseases in the Japanese population.

[ "0" ]

436

These results suggest that the @GENE$ gene region on chromosome 2q33 is a susceptibility locus for @DISEASE$ in the United Kingdom.

[ "1" ]

437

We conclude that the association of the @GENE$ intron 13 polymorphism with @DISEASE$, if any, is smaller than previously reported.

[ "1" ]

438

In conclusion, a significant association between @DISEASE$ and @GENE$ T51C polymorphism localized on chromosome 3p21 was found.

[ "1" ]

439

The D76N variant of @GENE$ does not significantly alter insulin secretion or act as a high-risk susceptibility allele for late-onset @DISEASE$ as proposed previously, although we cannot exclude a minor role in increasing risk of diabetes.

[ "1" ]

440

polymorphisms of @GENE$ and @DISEASE$ associate with type II diabetes and estimates of insulin resistance in Danish white subjects.

[ "0" ]

441

Results in the present study suggested that there was a coordinated effect between @GENE$ 1298 genotypes and habits of smoking, alcohol drinking and tea @DISEASE$ in the development of EC.

[ "0" ]

442

Our results suggest that the CYP11A1 polymorphism may have a significant influence on the development of advanced and/or high grade prostate cancer and the absence of the @GENE$ (tttta)4 allele, i.e., the homozygosity for the (tttta)6 or longer allele, could be a useful marker for the prediction of disease progression of @DISEASE$.

[ "1" ]

443

These findings in a large, well characterized asthma population, reveal that, while FLAP is an important enzyme in cys-LTs biosynthesis, polymorphisms in the @GENE$ gene are not likely to be functionally associated with the @DISEASE$ phenotype.

[ "1" ]

444

Homozygosity for the 5G allele of the @GENE$ gene is associated with normal glucose @DISEASE$ in pregnant women.

[ "0" ]

445

A significant association between @DISEASE$-1 infection and the presence of an allelic variant was observed in the case of the M2 and A332A haplotypes, thus presenting @GENE$ as a potentially novel HIV-1 susceptibility locus.

[ "1" ]

446

The @GENE$ 49 Ala allele confers an increased risk of @DISEASE$, independent of age and HLA-DQ genetic markers.

[ "1" ]

447

it is likely that PPARalpha gene does not have a major role in diabetes and @DISEASE$ in our populations, although we can not exclude a minor contribution of the @GENE$ gene to the risk of CHD associated with Type 2 diabetes through a modulation of atherogenic plasma lipids.

[ "1" ]

448

Our study provides the first evidence that @GENE$ polymorphism participates in the development of THS, and sheds light on the genetic causes of this @DISEASE$ and genetic differences between tamoxifen-treated individuals.

[ "0" ]

449

AACT * A6 allele may be associated with @DISEASE$ negatively in Shanghai area, and this effect only exists in non-@GENE$ * epsilon 4 AD.

[ "1" ]

450

We conclude that I/D-@GENE$ gene polymorphism has no important effect on susceptibility to @DISEASE$ or HAPE.

[ "0" ]

451

Given the lines of evidence from different genetic studies, we suggest that TNFalpha may play a role in @DISEASE$ of @GENE$.

[ "0" ]

452

Our study suggests for the first time that @GENE$ polymorphisms are associated with @DISEASE$.

[ "0" ]

453

Our results suggest an important role for @GENE$ in @DISEASE$ in women and also raise the possibility that previously proposed disease-associated SNPs in the HTR3A/B region in Caucasians are in linkage disequilibrium with haplotype block 2 of HTR3B in the Japanese.

[ "1" ]

454

Therefore, we show associations between Glu allele of @GENE$ (Glu298Asp) and @DISEASE$ and between 4a allele (ecNOS4a/4b) and diastolic dysfunction in patients with essential hypertension.

[ "0" ]

455

The results do not indicate that any of the three SNPs studied are associated with @DISEASE$, @GENE$ measures or lipid measures.

[ "0" ]

456

We propose that although mutations in @GENE$ and GDF9 are not a major cause of ovarian insufficiency, they may be involved in @DISEASE$.

[ "1" ]

457

These data therefore confirm the importance of SLC11A1 in tuberculosis susceptibility in humans and suggest that @GENE$ influences @DISEASE$ susceptibility by regulation of interleukin-10.

[ "1" ]

458

The polymorphisms of @GENE$ and p21 were significantly associated with the occurrence of smoking-related @DISEASE$ in Taiwan Chinese patients.

[ "1" ]

459

The urokinase @GENE$ activator (BamHI) and plasminogen activator inhibitor type 1 (HindIII) genotypes may serve as useful markers for heritability of @DISEASE$ associated with periodontal disease.

[ "0" ]

460

Our @DISEASE$ further supports the hypothesis that the shorter CAG repeat length of the @GENE$ gene is related to prostate enlargement.

[ "0" ]

461

Data from this study do not support a strong role for the @GENE$ Met98Lys variant in @DISEASE$, ADOA or LHON.

[ "0" ]

462

We found evidence that a SNP in @GENE$ is modestly associated with @DISEASE$ in whites from the ARIC study and the WGHS.

[ "1" ]

463

Genetic variation in @GENE$ may affect susceptibility to and increase risk for @DISEASE$ in Taiwanese aboriginals.

[ "1" ]

464

Although mutations in regulatory elements affecting gene function cannot be excluded, the @GENE$ gene does not seem to have a major role in primary @DISEASE$ in humans.

[ "1" ]

465

Our findings support the hypothesis that the @GENE$ gene participates in the etiopathogenesis of @DISEASE$.

[ "0" ]

466

Our findings support the hypothesis that @DISEASE$- and depression-related personality @GENE$ are associated with the BDNF polymorphism although the explained variance is low.

[ "0" ]

467

We conclude that variability at the @GENE$ locus is associated with obesity and other features of the @DISEASE$, but given the nature of the two SNPs, the risk haplotype is most probably a marker in linkage disequilibrium with an as yet unidentified polymorphism that affects plasma adiponectin levels and insulin sensitivity.

[ "0" ]

468

These findings suggest that apoD may be related to the cognitive decline observed in AD patients and that @GENE$ and apoE likely play different roles in the pathogenesis of @DISEASE$.

[ "1" ]

469

The @GENE$ 5A/6A promoter polymorphism does not appear to influence breast cancer susceptibility but may be linked to a higher risk for metastasizing among @DISEASE$ patients.

[ "1" ]

470

In conclusion, we have replicated the association of the HNF4alpha @GENE$ promoter haplotype with @DISEASE$ in a U.K. Caucasian population where there is no evidence of linkage to 20q.

[ "0" ]

471

The difference in phenotypes between the two related heterozygotes, and the observation of obesity in other family members without the mutation suggests that @DISEASE$ results from a varying combination of environmental, behavioural and multiple genetic factors (other than @GENE$), even within the same family.

[ "1" ]

472

@GENE$ is a major gene for @DISEASE$ but not hyperuricemia in Japanese.

[ "0" ]

473

Our data support the hypothesis that -463A polymorphism in the @GENE$ gene may reduce the susceptibility to @DISEASE$ in the Chinese.

[ "1" ]

474

These results indicate that @DISEASE$ with C pneumoniae leads mainly to the development and progression of severe @GENE$ in patients with variation in the MBL gene.

[ "0" ]

475

We found no evidence to suggest that BRAF is a low-risk @GENE$ @DISEASE$ susceptibility gene.

[ "0" ]

476

Thus, our analyses of the genetic variations of the @GENE$ gene suggest that, at least in French Caucasians, they do not represent a major cause of @DISEASE$.

[ "1" ]

477

We identify the significant association of the @GENE$*3 allele encoding a low catalytic activity protein as a risk gene in proximal digestive tract @DISEASE$ and as a potential marker for cancer susceptibility.

[ "0" ]

478

These results suggest that @GENE$ promoter polymorphisms may contribute, at least partially, to host antiviral activity for @DISEASE$.

[ "1" ]

479

Genetic variations in ADIPOR1 or @GENE$ are unlikely to lead to a common genetic predisposition to insulin resistance or @DISEASE$ in the Japanese population.

[ "1" ]

480

These results indicate that @GENE$ sequence variants are associated with a small increase in the risk of developing UC and may influence @DISEASE$ behavior.

[ "0" ]

481

Thus, the @GENE$ exon 1 polymorphism may represent a susceptibility marker for @DISEASE$ progression in diabetic patients.

[ "0" ]

482

The @GENE$ Trp719Arg polymorphism was not associated with the risk of clinical @DISEASE$ in this large replication study.

[ "1" ]

483

The @GENE$ genotype may have an independent association with @DISEASE$, although our evidence did not show statistical significance.

[ "0" ]

484

The @DISEASE$ mutation in exon 11 in @GENE$ gene may be related to CAD susceptibility in the Chinese population.

[ "0" ]

485

The insertion of the guanine in the promoter of the @GENE$ gene does not appear to increase the risk of development of pregnancy-induced hypertension, @DISEASE$.

[ "0" ]

486

Our results suggest that the @GENE$ 4G/5G promoter polymorphism is not associated CVD risk factors or incident @DISEASE$ events in the elderly.

[ "1" ]

487

The 363S allele of the N363S variant of @GENE$ is associated with the susceptibility to overweight in subjects with @DISEASE$.

[ "1" ]

488

We did not confirm the previously reported association of this @GENE$ polymorphism with @DISEASE$ in our UK population despite its ethnic similarities with the Swedish population in which it was first described.

[ "1" ]

489

These data provide a plausible biological explanation for the reduced risk for @DISEASE$ as observed in @GENE$ -463AA/AG compared with MPO -463GG subjects.

[ "0" ]

490

In conclusion, none of the polymorphisms were found to play a key role in the @GENE$ inducibility or in the susceptibility to develop @DISEASE$.

[ "0" ]

491

Our study indicates that the V418M polymorphism of @GENE$ contributes to the genetic regulation of femoral neck BMD in women and adds to accumulating evidence that indicates that subtle polymorphic variation in genes that cause monogenic @DISEASE$ also contribute to regulation of BMD in normal subjects.

[ "0" ]

492

Our results indicate a role of the @GENE$ gene in genetic predisposition of @DISEASE$ such as obesity, type 2 diabetes, and dyslipidemia.

[ "0" ]

493

IVS14A and 451Q @DISEASE$ of @GENE$ gene were rare in Chinese population and 442G mutant gene was possibly one of the susceptibility factors to CHD in Chinese.

[ "0" ]

494

Our data suggest that the @GENE$ Y402H polymorphism is a major risk factor for exudative @DISEASE$ in a Central European population.

[ "1" ]

495

These data implicate ASCA as a specific marker of @DISEASE$ location and progression in @GENE$, emphasizing the heterogeneity within IBD.

[ "0" ]

496

The present study demonstrates that the AA genotype of the Gly482Ser polymorphism in the @GENE$ gene might be a risk factor for diabetic retinopathy in the Slovene population (Caucasians) with @DISEASE$ (odds ratio 2.7, 95% confidence interval 1.0-6.8), whereas the Pro12Ala polymorphism of the PPARgamma gene failed to confer susceptibility to diabetic retinopathy.

[ "1" ]

497

These results suggest that @GENE$+3953 allele 2 may be a risk indicator for the susceptibility to severe @DISEASE$ in Uighur minority in Xingjiang of China.

[ "0" ]

498

These findings suggest that @GENE$ may be related to the cognitive decline observed in @DISEASE$ patients and that apoD and apoE likely play different roles in the pathogenesis of AD.

[ "1" ]

499

In this study, the @GENE$ C1772T polymorphism does not appear to influence EPO, Sao2, or @DISEASE$ responses during acute hypoxic exposure, or the magnitude of the HVR.

[ "0" ]