bigbio/gad · Datasets at Hugging Face

id stringlengths 1 4	document_id stringlengths 1 4	text stringlengths 42 538	labels list
800	800	The present study revealed an association between carrier state of Q allele of @GENE$ gene and @DISEASE$ as well as synergistic effects between genotype and some conventional risk factors, mainly smoking and elevated level of total cholesterol.	[ "1" ]
801	801	Our results suggest that APOE and @GENE$ genotypes may be independent risk factors for late-onset @DISEASE$, but the ACE association needs to be confirmed in independent samples in which the time and extent of vascular cofactors can be assessed.	[ "1" ]
802	802	polymorphisms in the @GENE$ gene analyzed here are not associated with @DISEASE$ in a Japanese population.	[ "1" ]
803	803	These data suggest that a @DISEASE$ in the @GENE$ gene promoter region, or a mutation in linkage disequilibrium with the promoter SNP, may be involved in the pathogenesis of chromosome 22-linked SZ.	[ "0" ]
804	804	@GENE$ insertion/@DISEASE$ polymorphism may determine rHuEPO responsiveness in CAPD patients and should be considered in relative rHuEPO resistance.	[ "0" ]
805	805	it is unlikely that @GENE$ E1317Q is associated with a clinically meaningful risk of @DISEASE$.	[ "1" ]
806	806	our study suggests that @GENE$ gene variants have no major influence on suicidal behavior but may modulate @DISEASE$ features.	[ "0" ]
807	807	The genetic information about @GENE$ from this study would be useful for further genetic study of obesity, @DISEASE$, and other metabolic diseases.	[ "0" ]
808	808	Together, @DISEASE$ is not associated with a promoter polymorphism in the @GENE$ gene nor with the production of IL-12p70 by LPS-stimulated blood cells.	[ "1" ]
809	809	These results suggest that @GENE$ polymorphisms/haplotypes may contribute to genetic susceptibility for @DISEASE$.	[ "1" ]
810	810	Our results suggest that S100B could be a susceptible gene for @DISEASE$ and provide indirect evidence for the @GENE$/SD hypothesis.	[ "0" ]
811	811	Although it has been hypothesized that the T(-295)C promoter polymorphism may be associated with increased @GENE$ gene expression, it is not associated with @DISEASE$, disease severity or atopy in this Australian population.	[ "0" ]
812	812	We conclude that functional @GENE$-uVNTR alleles may act as a genetic modifier of the severity of @DISEASE$ in males.	[ "1" ]
813	813	Our results suggest that deletion polymorphism of the @GENE$ gene is not associated with the pathogenesis of @DISEASE$ in Taiwanese.	[ "1" ]
814	814	The @DISEASE$ of phenotypic differences in normal tension glaucoma patients with and without the @GENE$ polymorphisms IVS 8 +4 C/T; +32 T/C suggest that these OPA1 polymorphisms do not underlie any major phenotypic diversity in these patients.	[ "0" ]
815	815	@GENE$ TaqIB polymorphism is significantly associated with the presence of @DISEASE$ in the context of micro- or macroalbuminuria, elevated C-reactive protein, renal dysfunction, and ischemic heart disease.	[ "1" ]
816	816	It is unlikely that the promoter polymorphisms -359T/C and -303A/G of the catalytic subunit @GENE$ gene of human PI 3-kinase have a major impact on insulin secretion, @DISEASE$, or the risk of type 2 diabetes in Finnish subjects.	[ "0" ]
817	817	The above results suggest that the Msp I polymorphisms of @GENE$ itself might not be associated with idiopathic early-onset @DISEASE$.	[ "1" ]
818	818	The results suggest that the familial @DISEASE$ is associated to the @GENE$ gene.	[ "0" ]
819	819	Persons who are homozygous for the @GENE$ +874A allele may have a higher risk of contracting @DISEASE$.	[ "1" ]
820	820	In the present case-control study, we found no evidence of an association between the Glu298Asp variant of the @GENE$ gene and @DISEASE$/MI among Taiwanese.	[ "1" ]
821	821	Our results suggest that the presence of these two @GENE$ polymorphisms may be a marker of genetic susceptibility to @DISEASE$.	[ "0" ]
822	822	These results suggested that @GENE$ polymorphism is associated with the impairment of aortic and carotid distensibility in patients with @DISEASE$.	[ "1" ]
823	823	@GENE$-antitrypsin @DISEASE$ is not related to the pathogenesis of idiopathic or hereditary CP.	[ "0" ]
824	824	No evidence for association of @GENE$ with @DISEASE$ was detected using family or case-control methods.	[ "1" ]
825	825	The results indicate that specific polymorphisms in the @GENE$, ESR1, and ESR2 genes may play a role in progression of BBD to @DISEASE$ among Caucasian women.	[ "1" ]
826	826	In conclusion, our study suggests a potential role of the K121Q polymorphism or derived @GENE$ haplotypes in increased susceptibility to @DISEASE$ and early impairment of glucose and insulin metabolism in children.	[ "0" ]
827	827	Our results collectively suggest that SNPs and haplotypes of the @GENE$ promoter region are associated with @DISEASE$ risk in the Korean population.	[ "1" ]
828	828	The lack of statistically significant difference between G/G frequencies in both groups of patients may suggest that @GENE$ G/G genotype is not a risk factor for @DISEASE$.	[ "1" ]
829	829	No association was seen between @GENE$ genotype and either @DISEASE$ or therapeutic response, suggesting that the benefits of treatment most likely overshadow the salutary effects of the V64I polymorphism.	[ "0" ]
830	830	The ChAT @GENE$ is a novel genetic risk factor @DISEASE$, and the SSVS is a useful approach for analyzing association with multiple candidate genes simultaneously.	[ "0" ]
831	831	Although the studied polymorphisms have been previously reported to constitute risk factors for the disease, we found no association between LTC4S -444 A/C, @GENE$ -176/-147, and ALOX5AP -169/-146 polymorphisms and @DISEASE$.	[ "1" ]
832	832	Although @GENE$ genetic variability is not related to the development of @DISEASE$, identification of variant haplotypes may, after larger prospective studies have been performed, provide clinicians with a tool for methadone dosage individualization.	[ "0" ]
833	833	In conclusion, we described a significant association between @GENE$ gene polymorphisms and @DISEASE$, suggesting a new genetic susceptibility factor for hyperinsulinemia, insulin resistance, and type 2 diabetes.	[ "1" ]
834	834	our study does not support the notion that @GENE$ and HTR1A gene variants are major contributors to @DISEASE$-, anger-, or aggression-related behaviors in our sample.	[ "0" ]
835	835	The increased allele sharing in the @GENE$ gene region on 19p13 is consistent with an important involvement of this region in migraine, especially @DISEASE$.	[ "0" ]
836	836	In our population, the +1073 C/T @GENE$ polymorphism exhibited a significant association with Alzheimer's disease, further supporting the role of OLR1 as a candidate risk gene for sporadic @DISEASE$.	[ "1" ]
837	837	Our data suggest that @GENE$ Q192R polymorphism was not independently associated with MI but further increased the risk of @DISEASE$ among the subjects with DM, obesity, or both, the conditions associated with high oxidative stress.	[ "1" ]
838	838	Both analyses support (@GENE$.046 for the proposed test, p = 0.028 for the case-control analysis) an association of the homozygous GSTM1 @DISEASE$ genotype with autism.	[ "0" ]
839	839	Mutations of the @GENE$ and of the GPR54 gene are rare in IHH and should be investigated especially in cases with autosomal recessive @DISEASE$.	[ "0" ]
840	840	The @GENE$-159 and -550 polymorphisms might not play a major role in the @DISEASE$ of food allergy in Japanese children.	[ "0" ]
841	841	These data point to a role of the @GENE$ haplotype in @DISEASE$ and raise the possibility of relative thienopyridine resistance in carriers of the P2Y12 H2 haplotype.	[ "0" ]
842	842	Since none of the remaining DRB104 subtypes was associated with type 1 DM, our study may present another piece of evidence that the DRB10401 and @GENE$*0404 alleles do not modify @DISEASE$ risk generally in European populations.	[ "1" ]
843	843	We conclude that carriers of a @GENE$ 936T-allele are at decreased risk for @DISEASE$, this, however, requiring further confirmation in a larger study.	[ "1" ]
844	844	The results from this study indicate that polymorphisms in LRP and @GENE$ are not associated with increased risk for @DISEASE$ in Northern Ireland.	[ "1" ]
845	845	In conclusion, this study revealed a strong association between P-selectin gene polymorphisms and serum @GENE$ levels and a complex age-dependent relation between soluble P-selectin levels and @DISEASE$, which suggests that this molecule might have different roles in the atherothrombotic process.	[ "1" ]
846	846	Results from this study suggest that rs4680 in the COMT gene and rs4646903 in the @GENE$ gene may be genetic markers for @DISEASE$ prognosis in Chinese women.	[ "1" ]
847	847	Our results show that besides @DISEASE$ stage, lymph node status, and tumor grade, the @GENE$ T393C status is a novel independent host factor for disease progression in patients with clear cell renal cell carcinoma and provides further evidence for the T393C polymorphism as a general prognostic tumor marker.	[ "0" ]
848	848	Although @GENE$ genotype was not reliably associated with @DISEASE$ lib drinking behavior, the results suggest that individuals with the long-long (LL) genotype may develop acute tolerance to alcohol effects more rapidly than heterozygotes or individuals homozygous for the short SERT allele.	[ "0" ]
849	849	These results indicate that elevated baseline @GENE$ levels and PPARA gene intron 7 G/G genotype were associated with TG reduction > 30% after fenofibrate treatment in patients with @DISEASE$.	[ "0" ]
850	850	Our data indicate that the X-chromosomal located +1675 G/A-polymorphism of the @GENE$-R gene is associated with LV structure in young male humans with early structural changes of the heart due to @DISEASE$.	[ "1" ]
851	851	We conclude that @GENE$ gene polymorphism is not associated with development of @DISEASE$.	[ "1" ]
852	852	The observation that CYP3A4 and CYP3A43 were associated with @DISEASE$, are not in linkage equilibrium, and are both involved in testosterone metabolism, suggest that both @GENE$1B and CYP3A433 may influence the probability of having prostate cancer and disease severity.	[ "1" ]
853	853	We conclude that the @GENE$ V600E @DISEASE$ in microsatellite-stable colon cancer is associated with a significantly poorer survival in stages 2 to 4 colon cancer but has no effect on the excellent prognosis of microsatellite-unstable tumors.	[ "0" ]
854	854	These results indicate that the @GENE$ variant haplotype is functionally significant in patients with sepsis, being associated with increased nuclear @DISEASE$ of NF-kappaB, more severe organ dysfunction, and higher mortality.	[ "0" ]
855	855	Our findings suggest that the A-G polymorphism of @GENE$ may confer susceptibility to @DISEASE$ behavior in MD patients.	[ "1" ]
856	856	@GENE$ G38A polymorphism had no association with the development of @DISEASE$, but the homogeneous 38AA genotype maybe one of the genetic markers for disease progression in Chinese IgA nephropathy.	[ "1" ]
857	857	Genetic polymorphism of XRCC1 R399Q is associated with response to platinum-based NAC in bulky @DISEASE$, and MDR analysis documented association between gene-gene interaction of @GENE$ R399Q and treatment response.	[ "1" ]
858	858	In conclusion, the results of the study in Korean @GENE$ 2 diabetic patients do not support the hypothesis that polymorphism at the 5' end of the aldose reductase gene contributes to the susceptibility to diabetic microvascular @DISEASE$.	[ "0" ]
859	859	These preliminary findings show for the first time that the @GENE$ His (213) allele is a possible risk factor for @DISEASE$ development.	[ "1" ]
860	860	We conclude that no significant association between I/D polymorphism and @DISEASE$ was demonstrable in either @GENE$ 1 or type 2 diabetes, despite considerable statistical power of the patient sample and adequate duration of diabetes for nephropathy to become manifest.	[ "0" ]
861	861	The expression of MIC genes on enterocytes under stressful conditions and their function as ligands of intraepithelial gammadelta and @GENE$ T cells, together with the data presented here suggest a potential role of MIC genes in the @DISEASE$ of CD.	[ "0" ]
862	862	The polymorphism of 8570G > A in @GENE$ may be associated with @DISEASE$ in the population of Han nationality from Hubei province of China.	[ "0" ]
863	863	Infant @GENE$ RR and PON2 CC genotypes were associated with preterm delivery in our study population, which suggests a possible role for human paraoxonase variability in the etiology of @DISEASE$.	[ "1" ]
864	864	Our data show that the exon 1 (+49) polymorphism of the @GENE$ gene is associated with @DISEASE$ in African Americans.	[ "1" ]
865	865	Despite the strikingly similar pathologies of @GENE$ syndrome and sarcoidosis, no mutations were found to be associated with @DISEASE$ in a group of patients, regardless of the presence of uveitis.	[ "1" ]
866	866	The present study demonstrates that the @GENE$ genotype of the Gly482Ser polymorphism in the PPARGC1 gene might be a risk factor for @DISEASE$ in the Slovene population (Caucasians) with type 2 diabetes (odds ratio 2.7, 95% confidence interval 1.0-6.8), whereas the Pro12Ala polymorphism of the PPARgamma gene failed to confer susceptibility to diabetic retinopathy.	[ "0" ]
867	867	Our results strongly suggest that the SNP of @GENE$ might be associated with susceptibility to @DISEASE$.	[ "0" ]
868	868	The association is found between the @DISEASE$ polymorphism and @GENE$, There is a significant correlation between the CC genotype of the APOA5 and the levels of plasma high density lipoprotein-cholosteal in the CHD group.	[ "0" ]
869	869	These results indicate that a genetic association exists between @GENE$ gene locus and severe @DISEASE$.	[ "0" ]
870	870	This is the first report that @GENE$, IL8, and PPARG genes are important in relation to inflammation-related risk of sporadic @DISEASE$.	[ "1" ]
871	871	these results may provide further support for an association between the @GENE$ gene (DTNBP1) and schizophrenia, but not between the @DISEASE$ and DAO, DAOA, NRG1 and RGS4 or with the interaction of these genes.	[ "0" ]
872	872	A positive correlation was found between LRP gene polymorphism and @DISEASE$, but not between @GENE$ gene polymorphism and AD in Chinese AD cases.	[ "1" ]
873	873	@GENE$ gene polymorphisms are not linked to @DISEASE$, suggesting that this gene does not have a role in the pathogenesis of optic neuropathy in this disease.	[ "0" ]
874	874	These results suggest that the rs1862214 polymorphism in PDCD5 is predictive for lung cancer risk and prognosis, and that @GENE$ may represent a novel tumor suppressor gene influencing @DISEASE$.	[ "1" ]
875	875	The impact of @GENE$ variants on risk of @DISEASE$ was mediated largely through the action of three common alleles, Arg151Cys, Arg160Trp, and Asp294His, that have previously been associated with red hair, fair skin, and skin sensitivity to ultraviolet light.	[ "1" ]
876	876	Our results suggest that the presence of the A-@GENE$ allele at the @DISEASE$ promoter region is associated with less aggressive forms of breast cancer and could be looked on as a favorable prognostic factor.	[ "0" ]
877	877	We provide evidence, for the first time, that @GENE$ promoter -514 C-->T polymorphism, by modulating LDL density, significantly affects the number of macrophages in the @DISEASE$ and possibly affects the occurrence of cerebrovascular events in patients with carotid artery stenosis.	[ "0" ]
878	878	Our data support a functional importance of the @GENE$ mutations for plasma concentrations and central @DISEASE$ actions of the opioid loperamide.	[ "0" ]
879	879	We conclude that the association of the FE65 intron @GENE$ polymorphism with @DISEASE$, if any, is smaller than previously reported.	[ "0" ]
880	880	None of the SNPs of KCNQ1 P448R, KCNQ1 R519H, KCNQ1 G643S, KCNE1 G38S and KCNE1 D85N was associated with atrial fibrillation phenotype, but @GENE$ E145D may relation to @DISEASE$.	[ "1" ]
881	881	Thus, there is a significant association between the PON1-192R allele and @DISEASE$; the @GENE$-192R allele may play an important role in the genesis of coronary spasm, probably by attenuating the suppression of oxidative stress.	[ "1" ]
882	882	The polymorphism in @GENE$ gene promoter (-173 G/C) does not appear to be genetic risk factors for @DISEASE$ in Northwest Spain.	[ "0" ]
883	883	In addition, these data suggest that @GENE$ repeat length may be partly responsible for the increased risk for early-onset @DISEASE$ in women who use OCs, although these findings need replication in other populations.	[ "1" ]
884	884	The results of our study suggest a role for the @GENE$ gene in modifying the clinical features of @DISEASE$.	[ "1" ]
885	885	We conclude that this study has failed to produce evidence in support of the notion that variations within these 24 candidate @GENE$ and asthma genes significantly influence the expression of the atopic @DISEASE$ phenotype or contribute to the susceptibility of atopic asthma.	[ "1" ]
886	886	These results suggested that the @GENE$ gene might be involved in the susceptibility to @DISEASE$ in the Chinese Han population and both +49 and CT60 of CTLA-4 gene might be the causal variants in RA disease.	[ "1" ]
887	887	Our data demonstrate that in B-@DISEASE$, plasma levels of @GENE$, IL-1Ra and IL-6 differ from normal, and mechanisms other than allelic imbalance of their genes account for the distinct cytokine profiles observed in this disease.	[ "0" ]
888	888	Our results suggest that the @GENE$ gene may play a minor role in the overall genetic predisposition to @DISEASE$ in this UK population.	[ "1" ]
889	889	These results suggested that among @GENE$ and related genes, IFNG and IRF1 genes confer genetic susceptibility to @DISEASE$ in Japanese children.	[ "1" ]
890	890	These results suggest that the @GENE$ gene is a target of genomic instability in MSI-positive @DISEASE$ and that the Chk1 framshift mutations might be involved in colorectal tumourigenesis through a defect in response to DNA damage in a subset of sporadic colorectal cancers and HNPCCs.	[ "1" ]
891	891	These results suggest no effect of the @GENE$ genotype on susceptibility to MS, but indicate an association of the APOE epsilon4 allele with a more severe course of the @DISEASE$.	[ "0" ]
892	892	This study identifies a novel genetic and clinical association between @GENE$ and @DISEASE$.	[ "0" ]
893	893	Our results suggest that the @GENE$ gene polymorphism may confer increased susceptibility to @DISEASE$.	[ "1" ]
894	894	Therefore, our results suggest that Glu298Asp @GENE$ polymorphism plays a role as a genetic susceptibility factor for @DISEASE$.	[ "1" ]
895	895	We conclude that the @GENE$ G(-174)C polymorphism is not associated with the risk of CAD or @DISEASE$ and does not contribute to cardiovascular risk stratification.	[ "1" ]
896	896	Together, our findings suggest that @GENE$ gene polymorphisms do not influence the susceptibility to @DISEASE$ or the clinical characteristics of MS in Japanese patients.	[ "1" ]
897	897	The A/T polymorphism of @GENE$ gene is associated with the risk factor for aneurysmal @DISEASE$.	[ "1" ]
898	898	The exon 3 @DISEASE$ in the @GENE$ predicts an improved response to pegvisomant therapy in acromegaly.	[ "0" ]
899	899	These results suggest the possibility that @GENE$ molecule play some part in formation of @DISEASE$, such as erythema nodosum in BD in Japanese.	[ "0" ]

800

The present study revealed an association between carrier state of Q allele of @GENE$ gene and @DISEASE$ as well as synergistic effects between genotype and some conventional risk factors, mainly smoking and elevated level of total cholesterol.

[ "1" ]

801

Our results suggest that APOE and @GENE$ genotypes may be independent risk factors for late-onset @DISEASE$, but the ACE association needs to be confirmed in independent samples in which the time and extent of vascular cofactors can be assessed.

[ "1" ]

802

polymorphisms in the @GENE$ gene analyzed here are not associated with @DISEASE$ in a Japanese population.

[ "1" ]

803

These data suggest that a @DISEASE$ in the @GENE$ gene promoter region, or a mutation in linkage disequilibrium with the promoter SNP, may be involved in the pathogenesis of chromosome 22-linked SZ.

[ "0" ]

804

@GENE$ insertion/@DISEASE$ polymorphism may determine rHuEPO responsiveness in CAPD patients and should be considered in relative rHuEPO resistance.

[ "0" ]

805

it is unlikely that @GENE$ E1317Q is associated with a clinically meaningful risk of @DISEASE$.

[ "1" ]

806

our study suggests that @GENE$ gene variants have no major influence on suicidal behavior but may modulate @DISEASE$ features.

[ "0" ]

807

The genetic information about @GENE$ from this study would be useful for further genetic study of obesity, @DISEASE$, and other metabolic diseases.

[ "0" ]

808

Together, @DISEASE$ is not associated with a promoter polymorphism in the @GENE$ gene nor with the production of IL-12p70 by LPS-stimulated blood cells.

[ "1" ]

809

These results suggest that @GENE$ polymorphisms/haplotypes may contribute to genetic susceptibility for @DISEASE$.

[ "1" ]

810

Our results suggest that S100B could be a susceptible gene for @DISEASE$ and provide indirect evidence for the @GENE$/SD hypothesis.

[ "0" ]

811

Although it has been hypothesized that the T(-295)C promoter polymorphism may be associated with increased @GENE$ gene expression, it is not associated with @DISEASE$, disease severity or atopy in this Australian population.

[ "0" ]

812

We conclude that functional @GENE$-uVNTR alleles may act as a genetic modifier of the severity of @DISEASE$ in males.

[ "1" ]

813

Our results suggest that deletion polymorphism of the @GENE$ gene is not associated with the pathogenesis of @DISEASE$ in Taiwanese.

[ "1" ]

814

The @DISEASE$ of phenotypic differences in normal tension glaucoma patients with and without the @GENE$ polymorphisms IVS 8 +4 C/T; +32 T/C suggest that these OPA1 polymorphisms do not underlie any major phenotypic diversity in these patients.

[ "0" ]

815

@GENE$ TaqIB polymorphism is significantly associated with the presence of @DISEASE$ in the context of micro- or macroalbuminuria, elevated C-reactive protein, renal dysfunction, and ischemic heart disease.

[ "1" ]

816

It is unlikely that the promoter polymorphisms -359T/C and -303A/G of the catalytic subunit @GENE$ gene of human PI 3-kinase have a major impact on insulin secretion, @DISEASE$, or the risk of type 2 diabetes in Finnish subjects.

[ "0" ]

817

The above results suggest that the Msp I polymorphisms of @GENE$ itself might not be associated with idiopathic early-onset @DISEASE$.

[ "1" ]

818

The results suggest that the familial @DISEASE$ is associated to the @GENE$ gene.

[ "0" ]

819

Persons who are homozygous for the @GENE$ +874A allele may have a higher risk of contracting @DISEASE$.

[ "1" ]

820

In the present case-control study, we found no evidence of an association between the Glu298Asp variant of the @GENE$ gene and @DISEASE$/MI among Taiwanese.

[ "1" ]

821

Our results suggest that the presence of these two @GENE$ polymorphisms may be a marker of genetic susceptibility to @DISEASE$.

[ "0" ]

822

These results suggested that @GENE$ polymorphism is associated with the impairment of aortic and carotid distensibility in patients with @DISEASE$.

[ "1" ]

823

@GENE$-antitrypsin @DISEASE$ is not related to the pathogenesis of idiopathic or hereditary CP.

[ "0" ]

824

No evidence for association of @GENE$ with @DISEASE$ was detected using family or case-control methods.

[ "1" ]

825

The results indicate that specific polymorphisms in the @GENE$, ESR1, and ESR2 genes may play a role in progression of BBD to @DISEASE$ among Caucasian women.

[ "1" ]

826

In conclusion, our study suggests a potential role of the K121Q polymorphism or derived @GENE$ haplotypes in increased susceptibility to @DISEASE$ and early impairment of glucose and insulin metabolism in children.

[ "0" ]

827

Our results collectively suggest that SNPs and haplotypes of the @GENE$ promoter region are associated with @DISEASE$ risk in the Korean population.

[ "1" ]

828

The lack of statistically significant difference between G/G frequencies in both groups of patients may suggest that @GENE$ G/G genotype is not a risk factor for @DISEASE$.

[ "1" ]

829

No association was seen between @GENE$ genotype and either @DISEASE$ or therapeutic response, suggesting that the benefits of treatment most likely overshadow the salutary effects of the V64I polymorphism.

[ "0" ]

830

The ChAT @GENE$ is a novel genetic risk factor @DISEASE$, and the SSVS is a useful approach for analyzing association with multiple candidate genes simultaneously.

[ "0" ]

831

Although the studied polymorphisms have been previously reported to constitute risk factors for the disease, we found no association between LTC4S -444 A/C, @GENE$ -176/-147, and ALOX5AP -169/-146 polymorphisms and @DISEASE$.

[ "1" ]

832

Although @GENE$ genetic variability is not related to the development of @DISEASE$, identification of variant haplotypes may, after larger prospective studies have been performed, provide clinicians with a tool for methadone dosage individualization.

[ "0" ]

833

In conclusion, we described a significant association between @GENE$ gene polymorphisms and @DISEASE$, suggesting a new genetic susceptibility factor for hyperinsulinemia, insulin resistance, and type 2 diabetes.

[ "1" ]

834

our study does not support the notion that @GENE$ and HTR1A gene variants are major contributors to @DISEASE$-, anger-, or aggression-related behaviors in our sample.

[ "0" ]

835

The increased allele sharing in the @GENE$ gene region on 19p13 is consistent with an important involvement of this region in migraine, especially @DISEASE$.

[ "0" ]

836

In our population, the +1073 C/T @GENE$ polymorphism exhibited a significant association with Alzheimer's disease, further supporting the role of OLR1 as a candidate risk gene for sporadic @DISEASE$.

[ "1" ]

837

Our data suggest that @GENE$ Q192R polymorphism was not independently associated with MI but further increased the risk of @DISEASE$ among the subjects with DM, obesity, or both, the conditions associated with high oxidative stress.

[ "1" ]

838

Both analyses support (@GENE$.046 for the proposed test, p = 0.028 for the case-control analysis) an association of the homozygous GSTM1 @DISEASE$ genotype with autism.

[ "0" ]

839

Mutations of the @GENE$ and of the GPR54 gene are rare in IHH and should be investigated especially in cases with autosomal recessive @DISEASE$.

[ "0" ]

840

The @GENE$-159 and -550 polymorphisms might not play a major role in the @DISEASE$ of food allergy in Japanese children.

[ "0" ]

841

These data point to a role of the @GENE$ haplotype in @DISEASE$ and raise the possibility of relative thienopyridine resistance in carriers of the P2Y12 H2 haplotype.

[ "0" ]

842

Since none of the remaining DRB1*04 subtypes was associated with type 1 DM, our study may present another piece of evidence that the DRB1*0401 and @GENE$*0404 alleles do not modify @DISEASE$ risk generally in European populations.

[ "1" ]

843

We conclude that carriers of a @GENE$ 936T-allele are at decreased risk for @DISEASE$, this, however, requiring further confirmation in a larger study.

[ "1" ]

844

The results from this study indicate that polymorphisms in LRP and @GENE$ are not associated with increased risk for @DISEASE$ in Northern Ireland.

[ "1" ]

845

In conclusion, this study revealed a strong association between P-selectin gene polymorphisms and serum @GENE$ levels and a complex age-dependent relation between soluble P-selectin levels and @DISEASE$, which suggests that this molecule might have different roles in the atherothrombotic process.

[ "1" ]

846

Results from this study suggest that rs4680 in the COMT gene and rs4646903 in the @GENE$ gene may be genetic markers for @DISEASE$ prognosis in Chinese women.

[ "1" ]

847

Our results show that besides @DISEASE$ stage, lymph node status, and tumor grade, the @GENE$ T393C status is a novel independent host factor for disease progression in patients with clear cell renal cell carcinoma and provides further evidence for the T393C polymorphism as a general prognostic tumor marker.

[ "0" ]

848

Although @GENE$ genotype was not reliably associated with @DISEASE$ lib drinking behavior, the results suggest that individuals with the long-long (LL) genotype may develop acute tolerance to alcohol effects more rapidly than heterozygotes or individuals homozygous for the short SERT allele.

[ "0" ]

849

These results indicate that elevated baseline @GENE$ levels and PPARA gene intron 7 G/G genotype were associated with TG reduction > 30% after fenofibrate treatment in patients with @DISEASE$.

[ "0" ]

850

Our data indicate that the X-chromosomal located +1675 G/A-polymorphism of the @GENE$-R gene is associated with LV structure in young male humans with early structural changes of the heart due to @DISEASE$.

[ "1" ]

851

We conclude that @GENE$ gene polymorphism is not associated with development of @DISEASE$.

[ "1" ]

852

The observation that CYP3A4 and CYP3A43 were associated with @DISEASE$, are not in linkage equilibrium, and are both involved in testosterone metabolism, suggest that both @GENE$*1B and CYP3A43*3 may influence the probability of having prostate cancer and disease severity.

[ "1" ]

853

We conclude that the @GENE$ V600E @DISEASE$ in microsatellite-stable colon cancer is associated with a significantly poorer survival in stages 2 to 4 colon cancer but has no effect on the excellent prognosis of microsatellite-unstable tumors.

[ "0" ]

854

These results indicate that the @GENE$ variant haplotype is functionally significant in patients with sepsis, being associated with increased nuclear @DISEASE$ of NF-kappaB, more severe organ dysfunction, and higher mortality.

[ "0" ]

855

Our findings suggest that the A-G polymorphism of @GENE$ may confer susceptibility to @DISEASE$ behavior in MD patients.

[ "1" ]

856

@GENE$ G38A polymorphism had no association with the development of @DISEASE$, but the homogeneous 38AA genotype maybe one of the genetic markers for disease progression in Chinese IgA nephropathy.

[ "1" ]

857

Genetic polymorphism of XRCC1 R399Q is associated with response to platinum-based NAC in bulky @DISEASE$, and MDR analysis documented association between gene-gene interaction of @GENE$ R399Q and treatment response.

[ "1" ]

858

In conclusion, the results of the study in Korean @GENE$ 2 diabetic patients do not support the hypothesis that polymorphism at the 5' end of the aldose reductase gene contributes to the susceptibility to diabetic microvascular @DISEASE$.

[ "0" ]

859

These preliminary findings show for the first time that the @GENE$ His (213) allele is a possible risk factor for @DISEASE$ development.

[ "1" ]

860

We conclude that no significant association between I/D polymorphism and @DISEASE$ was demonstrable in either @GENE$ 1 or type 2 diabetes, despite considerable statistical power of the patient sample and adequate duration of diabetes for nephropathy to become manifest.

[ "0" ]

861

The expression of MIC genes on enterocytes under stressful conditions and their function as ligands of intraepithelial gammadelta and @GENE$ T cells, together with the data presented here suggest a potential role of MIC genes in the @DISEASE$ of CD.

[ "0" ]

862

The polymorphism of 8570G > A in @GENE$ may be associated with @DISEASE$ in the population of Han nationality from Hubei province of China.

[ "0" ]

863

Infant @GENE$ RR and PON2 CC genotypes were associated with preterm delivery in our study population, which suggests a possible role for human paraoxonase variability in the etiology of @DISEASE$.

[ "1" ]

864

Our data show that the exon 1 (+49) polymorphism of the @GENE$ gene is associated with @DISEASE$ in African Americans.

[ "1" ]

865

Despite the strikingly similar pathologies of @GENE$ syndrome and sarcoidosis, no mutations were found to be associated with @DISEASE$ in a group of patients, regardless of the presence of uveitis.

[ "1" ]

866

The present study demonstrates that the @GENE$ genotype of the Gly482Ser polymorphism in the PPARGC1 gene might be a risk factor for @DISEASE$ in the Slovene population (Caucasians) with type 2 diabetes (odds ratio 2.7, 95% confidence interval 1.0-6.8), whereas the Pro12Ala polymorphism of the PPARgamma gene failed to confer susceptibility to diabetic retinopathy.

[ "0" ]

867

Our results strongly suggest that the SNP of @GENE$ might be associated with susceptibility to @DISEASE$.

[ "0" ]

868

The association is found between the @DISEASE$ polymorphism and @GENE$, There is a significant correlation between the CC genotype of the APOA5 and the levels of plasma high density lipoprotein-cholosteal in the CHD group.

[ "0" ]

869

These results indicate that a genetic association exists between @GENE$ gene locus and severe @DISEASE$.

[ "0" ]

870

This is the first report that @GENE$, IL8, and PPARG genes are important in relation to inflammation-related risk of sporadic @DISEASE$.

[ "1" ]

871

these results may provide further support for an association between the @GENE$ gene (DTNBP1) and schizophrenia, but not between the @DISEASE$ and DAO, DAOA, NRG1 and RGS4 or with the interaction of these genes.

[ "0" ]

872

A positive correlation was found between LRP gene polymorphism and @DISEASE$, but not between @GENE$ gene polymorphism and AD in Chinese AD cases.

[ "1" ]

873

@GENE$ gene polymorphisms are not linked to @DISEASE$, suggesting that this gene does not have a role in the pathogenesis of optic neuropathy in this disease.

[ "0" ]

874

These results suggest that the rs1862214 polymorphism in PDCD5 is predictive for lung cancer risk and prognosis, and that @GENE$ may represent a novel tumor suppressor gene influencing @DISEASE$.

[ "1" ]

875

The impact of @GENE$ variants on risk of @DISEASE$ was mediated largely through the action of three common alleles, Arg151Cys, Arg160Trp, and Asp294His, that have previously been associated with red hair, fair skin, and skin sensitivity to ultraviolet light.

[ "1" ]

876

Our results suggest that the presence of the A-@GENE$ allele at the @DISEASE$ promoter region is associated with less aggressive forms of breast cancer and could be looked on as a favorable prognostic factor.

[ "0" ]

877

We provide evidence, for the first time, that @GENE$ promoter -514 C-->T polymorphism, by modulating LDL density, significantly affects the number of macrophages in the @DISEASE$ and possibly affects the occurrence of cerebrovascular events in patients with carotid artery stenosis.

[ "0" ]

878

Our data support a functional importance of the @GENE$ mutations for plasma concentrations and central @DISEASE$ actions of the opioid loperamide.

[ "0" ]

879

We conclude that the association of the FE65 intron @GENE$ polymorphism with @DISEASE$, if any, is smaller than previously reported.

[ "0" ]

880

None of the SNPs of KCNQ1 P448R, KCNQ1 R519H, KCNQ1 G643S, KCNE1 G38S and KCNE1 D85N was associated with atrial fibrillation phenotype, but @GENE$ E145D may relation to @DISEASE$.

[ "1" ]

881

Thus, there is a significant association between the PON1-192R allele and @DISEASE$; the @GENE$-192R allele may play an important role in the genesis of coronary spasm, probably by attenuating the suppression of oxidative stress.

[ "1" ]

882

The polymorphism in @GENE$ gene promoter (-173 G/C) does not appear to be genetic risk factors for @DISEASE$ in Northwest Spain.

[ "0" ]

883

In addition, these data suggest that @GENE$ repeat length may be partly responsible for the increased risk for early-onset @DISEASE$ in women who use OCs, although these findings need replication in other populations.

[ "1" ]

884

The results of our study suggest a role for the @GENE$ gene in modifying the clinical features of @DISEASE$.

[ "1" ]

885

We conclude that this study has failed to produce evidence in support of the notion that variations within these 24 candidate @GENE$ and asthma genes significantly influence the expression of the atopic @DISEASE$ phenotype or contribute to the susceptibility of atopic asthma.

[ "1" ]

886

These results suggested that the @GENE$ gene might be involved in the susceptibility to @DISEASE$ in the Chinese Han population and both +49 and CT60 of CTLA-4 gene might be the causal variants in RA disease.

[ "1" ]

887

Our data demonstrate that in B-@DISEASE$, plasma levels of @GENE$, IL-1Ra and IL-6 differ from normal, and mechanisms other than allelic imbalance of their genes account for the distinct cytokine profiles observed in this disease.

[ "0" ]

888

Our results suggest that the @GENE$ gene may play a minor role in the overall genetic predisposition to @DISEASE$ in this UK population.

[ "1" ]

889

These results suggested that among @GENE$ and related genes, IFNG and IRF1 genes confer genetic susceptibility to @DISEASE$ in Japanese children.

[ "1" ]

890

These results suggest that the @GENE$ gene is a target of genomic instability in MSI-positive @DISEASE$ and that the Chk1 framshift mutations might be involved in colorectal tumourigenesis through a defect in response to DNA damage in a subset of sporadic colorectal cancers and HNPCCs.

[ "1" ]

891

These results suggest no effect of the @GENE$ genotype on susceptibility to MS, but indicate an association of the APOE epsilon4 allele with a more severe course of the @DISEASE$.

[ "0" ]

892

This study identifies a novel genetic and clinical association between @GENE$ and @DISEASE$.

[ "0" ]

893

Our results suggest that the @GENE$ gene polymorphism may confer increased susceptibility to @DISEASE$.

[ "1" ]

894

Therefore, our results suggest that Glu298Asp @GENE$ polymorphism plays a role as a genetic susceptibility factor for @DISEASE$.

[ "1" ]

895

We conclude that the @GENE$ G(-174)C polymorphism is not associated with the risk of CAD or @DISEASE$ and does not contribute to cardiovascular risk stratification.

[ "1" ]

896

Together, our findings suggest that @GENE$ gene polymorphisms do not influence the susceptibility to @DISEASE$ or the clinical characteristics of MS in Japanese patients.

[ "1" ]

897

The A/T polymorphism of @GENE$ gene is associated with the risk factor for aneurysmal @DISEASE$.

[ "1" ]

898

The exon 3 @DISEASE$ in the @GENE$ predicts an improved response to pegvisomant therapy in acromegaly.

[ "0" ]

899

These results suggest the possibility that @GENE$ molecule play some part in formation of @DISEASE$, such as erythema nodosum in BD in Japanese.

[ "0" ]