bigbio/gad · Datasets at Hugging Face

id stringlengths 1 4	document_id stringlengths 1 4	text stringlengths 42 538	labels list
1000	1000	The association found between TLR4 genotype and risk of @DISEASE$ suggests that TLR4 genetic variants could potentially affect the susceptibility to MI and that @GENE$-mediated innate immunity is implicated in the pathogenesis of MI.	[ "1" ]
1001	1001	This study has shown that the position of the @GENE$ @DISEASE$ is significantly associated with earlier ESRD and questions whether PKD1 mutations simply inactivate all products of the gene.	[ "0" ]
1002	1002	These data suggest that the R497K polymorphism of the @GENE$, by reducing its activation and a consequential down-regulation of its target genes, could be a key determinant for reduced tumor recurrence of stage II/III @DISEASE$ patients receiving curative surgery and a longer survival of patients with stage II/III as well as metastatic colorectal carcinoma.	[ "1" ]
1003	1003	105V/114V alleles of @GENE$ and 113H/139H alleles of mEPHX and the combination of genotypes with same alleles associated with imbalanced @DISEASE$ and lung function in patients, signifying the importance in the disease.	[ "0" ]
1004	1004	the @GENE$*3 polymorphism may be an important factor in determining the dose requirement for tacrolimus and genotyping can help determine the initial daily dose required by individual patients for adequate @DISEASE$.	[ "0" ]
1005	1005	In conclusion, our results suggest that the @GENE$ gene or other genes in the region may increase the susceptibility to prostate cancer in men; however, the polymorphism in the 5' promoter region has a minor role if any in increasing @DISEASE$ susceptibility in our study sample.	[ "1" ]
1006	1006	While these preliminary findings should be interpreted cautiously, our data suggest that the @GENE$ VNTR polymorphism is associated with measures of @DISEASE$ in a sample of children displaying extreme, persistent and pervasive aggression.	[ "0" ]
1007	1007	(1) DRB1 * 0405 and DRB1 * 15 are closely associated with the susceptibility to @DISEASE$, @GENE$ * 0405 may be the major susceptible gene and DRB1 * 15 may be the minor; (2) DRB1 * 14 and DRB1 * 08 are negatively associated with the susceptibility to VKH syndrome, suggesting that they may be the resistant genes; (3) DRB1 * 0405 is not related to the clinical features, incidence of ocular complications as well as visual prognosis.	[ "1" ]
1008	1008	SNPs in the @GENE$ and @DISEASE$ genes contribute to plasma levels of high-density lipoprotein cholesterol.	[ "0" ]
1009	1009	The M55L and Q192R SNPs of the @GENE$ gene do not appear to be associated with late @DISEASE$ in individuals of Anglo-Celtic descent.	[ "1" ]
1010	1010	We report that rs2918419 was linked with @DISEASE$ and @GENE$ resistance in men.	[ "0" ]
1011	1011	Our results clearly demonstrate that promoter variants associated with @DISEASE$ in humans substantially affect @GENE$ promoter activity in adipocytes.	[ "0" ]
1012	1012	We conclude than In our population, as other worldwide countries, the homozygous for arginine at codon 72 of the @GENE$ gene is not a risk factor to @DISEASE$.	[ "1" ]
1013	1013	The results of our study revealed that HindIII polymorphism of the @GENE$ gene is highly associated with calcium oxalate stone @DISEASE$.	[ "0" ]
1014	1014	Our matched case-control and family study indicate that Cx50, but not @GENE$, may play a role in the genetic susceptibility to @DISEASE$.	[ "0" ]
1015	1015	No significant association between the @GENE$ and HLA-DQ loci and @DISEASE$ in Han nationality in Hunan province was confirmed.	[ "1" ]
1016	1016	Our observations suggest that this polymorphism could play a role in beta-@GENE$ @DISEASE$.	[ "0" ]
1017	1017	CTLA-4 49 AA is protective from @DISEASE$, whereas, @GENE$ 49 G allele (both as homozygotes and as heterozygotes ) confers an increased risk of diabetes mellitus.	[ "1" ]
1018	1018	This study provides the first in vivo evidence of a role for @GENE$ in modifying @DISEASE$ and CHD risk in humans.	[ "0" ]
1019	1019	Our prospective findings suggest that individuals carrying the @GENE$ C282Y mutation may be at increased risk of @DISEASE$.	[ "1" ]
1020	1020	These findings suggest that genetic polymorphisms of @GENE$ are associated with increased risk and a @DISEASE$ free survival of breast cancer in Korean women.	[ "0" ]
1021	1021	In conclusion, the presence of the @GENE$ gene D allele in this sample of normoalbuminuric normotensive Type 1 diabetic patients was associated with a higher proportion of microvascular @DISEASE$ and hypertension.	[ "0" ]
1022	1022	mutations in the @GENE$ gene are only a rare cause of @DISEASE$.	[ "0" ]
1023	1023	We conclude that the strongest association between CTLA4 gene polymorphisms and @DISEASE$ susceptibility occurs with the 3' @GENE$ polymorphism.	[ "0" ]
1024	1024	The @GENE$-3'A allele is associated with a lower presence of subclinical @DISEASE$ in an HIV-infected population.	[ "0" ]
1025	1025	These data suggest that the polymorphisms involved in differences in @GENE$ gene regulation may influence the @DISEASE$ of diabetic vascular complications.	[ "0" ]
1026	1026	@GENE$ 1420C/T genotype could significantly reduce susceptibilities to ESCC and @DISEASE$ among individuals from high risk areas in Hebei Province of China.	[ "0" ]
1027	1027	We can conclude that patients with microsatellite unstable double primary @DISEASE$ of the colorectum and the endometrium have a very high risk of carrying a mutation not only in @GENE$ or MSH2 but also in MSH6, especially if they get their first cancer diagnosis before the age of 50.	[ "0" ]
1028	1028	The @GENE$(-13910) and G/G(-22018) genotype of @DISEASE$ is not associated with susceptibility to the pathogenesis of Crohn disease and ulcerative colitis.	[ "0" ]
1029	1029	The results of our group and from the British and French studies strongly suggest that polymorphisms of the @GENE$ gene do not play a role in susceptibility to @DISEASE$ in European populations.	[ "1" ]
1030	1030	This study establishes that missense, nonsense, @DISEASE$, and splice site mutations of the @GENE$ gene are associated with about half of all malignancies originating from extraadrenal paragangliomas.	[ "0" ]
1031	1031	The results of this study indicate that the missense @DISEASE$ in plasma @GENE$ is associated with development of atherosclerosis in the elderly.	[ "0" ]
1032	1032	Our data suggest that the -344C allele of @GENE$ gene polymorphism is associated with the genetic predisposition to develop @DISEASE$.	[ "1" ]
1033	1033	@GENE$ intron 2 VNTR allele 2 may be a risk indicator for the susceptibility of severe @DISEASE$ in Uighur patients of Xinjiang.	[ "0" ]
1034	1034	It was suggested that @GENE$ gene C677T @DISEASE$ was a possible risk factor of Chinese premature coronary heart disease.	[ "0" ]
1035	1035	The present study suggests that the C-106T polymorphism of the @GENE$ gene could be involved in the early development of @DISEASE$ in Finnish Type 2 diabetic patients.	[ "0" ]
1036	1036	These results indicate that @GENE$ might be a strong candidate for conferring susceptibility to @DISEASE$ across different ethnicities.	[ "1" ]
1037	1037	A higher prevalence of @GENE$-54 @DISEASE$ was found in 5 Chinese nationalities, MBP-54 mutation was not associated with the persistence of hepatitis B.	[ "0" ]
1038	1038	Our results further support the idea that the PROGINS polymorphism of the @GENE$ may be associated with an increased risk of @DISEASE$.	[ "1" ]
1039	1039	There does not appear to be an association of the @GENE$ gene mutation with @DISEASE$ and therefore it is unlikely to be involved in the etiology of IBD.	[ "1" ]
1040	1040	The @GENE$ G2677T and C3435T polymorphisms may help predict the response to radiotherapy in @DISEASE$ patients.	[ "1" ]
1041	1041	Our findings suggest that the 4a allele and the @GENE$ combined genotypes are independent predisposing factors to @DISEASE$.	[ "1" ]
1042	1042	Large genomic rearrangements in @GENE$ are not a common cause of @DISEASE$.	[ "1" ]
1043	1043	Our results suggest that the @GENE$ C677T and MTRR A66G polymorphisms influence the risk of ESCC and @DISEASE$ in this population.	[ "0" ]
1044	1044	Replication of the original @GENE$ findings in these 4 additional asthma populations suggests that this gene (and perhaps others that interact with it) is important in the development and @DISEASE$ of asthma.	[ "0" ]
1045	1045	A strong interaction between SNP309 status and tumor @GENE$ status appears to modify the association between p53 status and @DISEASE$ survival.	[ "1" ]
1046	1046	Our data, therefore, do not support the hypothesis that genetic variation in @GENE$ and COMT is involved individually or in combination in the etiology of @DISEASE$.	[ "1" ]
1047	1047	Our results reveal that the allele @GENE$ is strongly associated with @DISEASE$ but not with withdrawal symptoms or daily alcohol intake.	[ "0" ]
1048	1048	A genetic variant of @GENE$ predisposes patients to @DISEASE$.	[ "0" ]
1049	1049	The data suggest that @GENE$ promoter C+33T polymorphism may be one of the genetic polymorphisms that explain genetic linkage or association between elevated total serum IgE levels and markers on chromosome @DISEASE$.	[ "0" ]
1050	1050	No association was found between the previously implicated polymorphisms of @GENE$, IL-10, CD14 and MnSOD, either individually or simultaneously, and the presence of established @DISEASE$.	[ "0" ]
1051	1051	@GENE$ is not generally associated with T-cell mediated @DISEASE$, although it might play a role in the CD patients with early clinical manifestation.	[ "0" ]
1052	1052	The @GENE$ R219K polymorphism may be involved in the variability of serum HDL-C and the susceptibility to @DISEASE$.	[ "0" ]
1053	1053	After evaluating for the first time the influence of @GENE$ promoter polymorphism in @DISEASE$, it seems to have no major effect on disease susceptibility and/or outcome.	[ "1" ]
1054	1054	The @GENE$ gene may, therefore, be a susceptibility gene in some vitiligo patients, further supporting the epidermal oxidative stress model for @DISEASE$ pathogenesis.	[ "1" ]
1055	1055	These findings indicate that @GENE$ is not a major @DISEASE$ susceptibility gene.	[ "1" ]
1056	1056	there is a statistically significant association between @DISEASE$ and dopamine system genes, especially @GENE$ and DRD5.	[ "1" ]
1057	1057	@GENE$(*)0103 is associated with susceptibility to ulcerative colitis, and IKBL+738(C) marks a propensity to extensive and more severe @DISEASE$.	[ "0" ]
1058	1058	We found no significant association of @DISEASE$ with the trinucleotide repeat polymorphism of the reelin or @GENE$ genes, suggesting that these polymorphisms do not have a major role in the pathogenesis of the disease.	[ "1" ]
1059	1059	These findings show that the C178T(Pro16Ser) variant in @GENE$ may represent a functional variant and affect the susceptibility to @DISEASE$.	[ "1" ]
1060	1060	These results indicate that mutations in NLGN3 and @GENE$ genes are responsible for at most a small fraction of autism cases and additional screenings in other autistic populations are needed to better determine the frequency with which mutations in NLGN3 and NLGN4 occur in @DISEASE$.	[ "1" ]
1061	1061	we report significant association of variants of @GENE$ with ischemic stroke and @DISEASE$ subtypes among whites.	[ "1" ]
1062	1062	These results suggest that there is no overall association between rare alleles of the @GENE$ VNTR and @DISEASE$.	[ "1" ]
1063	1063	The var321 and @DISEASE$(s) in the coding region of the @GENE$ gene probably are a rare cause of TS in a Caucasian population; therefore, genetic heterogeneity of TS should be considered.	[ "0" ]
1064	1064	The @DISEASE$ questionnaire may be used in large-scale epidemiological studies as a surrogate marker of @GENE$ genotype to predict individual cancer risk.	[ "0" ]
1065	1065	A2 allele of the @GENE$ gene is an independent risk factor for LVD @DISEASE$ in males.	[ "1" ]
1066	1066	These findings suggest a potentially important role for the @GENE$ gene in predisposition to @DISEASE$.	[ "1" ]
1067	1067	This observation may imply that the aberrant @GENE$ product has some relation to the development and/or @DISEASE$ of cancers in a variety of human tissues.	[ "0" ]
1068	1068	The @GENE$ polymorphism 25CAG appears to be a new genetic marker for @DISEASE$ susceptibility, at least in Japanese.	[ "1" ]
1069	1069	These results suggest that the high activity @GENE$*1 allozyme protects against dietary and/or environmental chemicals involved in the pathogenesis of @DISEASE$.	[ "1" ]
1070	1070	our data suggests that the A2M D allele is a modest risk factor for late-onset sporadic AD in Koreans, and the @DISEASE$ risk conferred by the @GENE$ D allele increases in APOE epsilon4 negative subjects.	[ "1" ]
1071	1071	Our findings suggest that the variants in @GENE$, or in a nearby gene, may be associated with @DISEASE$ in black men.	[ "1" ]
1072	1072	We can find no genetic influence for these polymorphisms in HLA class I/@GENE$, TNF-alpha/LT-alpha and IL-10 loci on either predisposition or @DISEASE$ in MDS/AML.	[ "0" ]
1073	1073	This study independently verifies the influence of @GENE$ and IDH1 on @DISEASE$ transmission, and its findings suggest that variation in these genes affects susceptibility to HIV infection in exposed individuals.	[ "0" ]
1074	1074	Our study does not support a role of @GENE$ and UGT1A6 genetic variations in the development of @DISEASE$.	[ "0" ]
1075	1075	We found that XPA A23G and XPC Lys939Gln polymorphisms may be risk factors for @DISEASE$ and evidence that positive interactions between the polymorphisms in XPA/XPD and @GENE$/XPD may occur.	[ "1" ]
1076	1076	The results show that @GENE$ I249 is an independent genetic risk factor for coronary artery disease and that CX3CR1 may be involved in the @DISEASE$ of atherosclerotic disease.	[ "0" ]
1077	1077	These data suggest that G1704T and G82S polymorphisms of the @GENE$ gene are not related to @DISEASE$ in Japanese type 2 diabetic patients.	[ "0" ]
1078	1078	@GENE$ * 0301, * 0303 alleles are susceptible alleles, and possibly they are the pathogenic genes, * 0601, * 0602 are resistant alleles, and may be they @DISEASE$ the protective property.	[ "0" ]
1079	1079	Our results do not confirm the association of @GENE$ polymorphism (promoter -159 C to T @DISEASE$) with asthma in Polish children.	[ "0" ]
1080	1080	The @GENE$-Delta32 and CCR2-64I alleles had a strong protective effect on @DISEASE$ of HIV-1 infection, but SDF-1 3'A homozygosity carried no such protection.	[ "0" ]
1081	1081	Our results identify a subgroup of @GENE$ 1 diabetic patients that is sensitive to allelic variation of the negative regulatory molecule CTLA-4 and indicate that TPOAbs testing could be used to subclassify @DISEASE$ patients for inclusion in genetic, biological or clinical studies.	[ "0" ]
1082	1082	In Bangladesh, the @GENE$ N34S @DISEASE$ increases the risk of several forms of pancreatic disease, including fibrocalculous pancreatic diabetes, tropical calcific pancreatitis, and non-insulin-dependent diabetes mellitus.	[ "0" ]
1083	1083	The results indicate that @GENE$0301 and 0401 alleles are associated with both @DISEASE$ and adenomyosis, and there is perhaps common mechanism involved in both endometriosis and adenomyosis based on HLA-DQA1 and HLA-DRB1 allele frequencies.	[ "0" ]
1084	1084	Our results suggest a potential implication of the @GENE$ -1154 G-->A and -634 G-->C polymorphisms in the development of @DISEASE$ in patients with HSP.	[ "0" ]
1085	1085	Although no association was observed between the @GENE$ promoter polymorphism and coronary in-stent @DISEASE$ following the stent procedure, the association with plasma IL-6 levels suggests that HO-1 S allele might protect from the atherosclerotic inflammatory process.	[ "0" ]
1086	1086	The @GENE$ locus influences susceptibility to @DISEASE$ in our patient group; however, it has no significant effect on the immune response or on the clinical course of the disease.	[ "0" ]
1087	1087	polymorphisms 4, 7 and *9 of @GENE$ were detected in approximately three out of four Japanese smokers, and their daily cigarette @DISEASE$ was genetically modulated by these functional polymorphisms.	[ "0" ]
1088	1088	The data suggest that the polymorphism in exon 10 of the @GENE$ gene may be associated with resistance to oxaliplatin/5-FU chemotherapy in advanced @DISEASE$.	[ "1" ]
1089	1089	Our results suggest that a dysregulation of @GENE$-driven downregulation of T-cell activation could be involved in the pathogenesis of @DISEASE$.	[ "1" ]
1090	1090	Our results provide evidence suggesting that @GENE$ is involved in the @DISEASE$ of OA of the hip.	[ "0" ]
1091	1091	These results suggest that the @GENE$ gene is a target of genomic instability in MSI-positive colorectal cancers and that the Chk1 framshift mutations might be involved in colorectal tumourigenesis through a defect in response to DNA damage in a subset of sporadic @DISEASE$ and HNPCCs.	[ "1" ]
1092	1092	Our data indicate that these @GENE$ polymorphisms have no influence on the incidence, progression and inflammatory parameters of @DISEASE$.	[ "1" ]
1093	1093	@GENE$ TaqIB polymorphism is significantly associated with the presence of AF in the context of micro- or macroalbuminuria, elevated C-reactive protein, renal @DISEASE$, and ischemic heart disease.	[ "0" ]
1094	1094	The Ter447 variant of @GENE$ is associated with decreased risk of brain infarction and @DISEASE$ in our very elderly population.	[ "0" ]
1095	1095	@GENE$ gene C677T @DISEASE$ associated with a predisposition to increased plasma homocysteine levels may represent a genetic risk factor for diabetic nephropathy in Chinese type 2 diabetes mellitus.	[ "0" ]
1096	1096	Our functional and genetic findings identify @GENE$ as an @DISEASE$-susceptibility gene.	[ "1" ]
1097	1097	The @GENE$ Glu298Asp polymorphism does not appear to influence the risk of developing @DISEASE$ in an Italian population.	[ "0" ]
1098	1098	polymorphism in the @GENE$ gene is limited, and although the 1012T genotype appears to influence perforin expression, it was not conclusively associated with disease progression in @DISEASE$.	[ "1" ]
1099	1099	Although variations of the @GENE$ and alpha(1D) genes are not associated with the development of common @DISEASE$, further studies may determine the role of these genomic variations, especially those in the alpha(1D) VDCC gene, in the pathogenesis of certain subsets of type 2 diabetes, or as a co-factor in the polygenic disorder generally.	[ "0" ]

1000

The association found between TLR4 genotype and risk of @DISEASE$ suggests that TLR4 genetic variants could potentially affect the susceptibility to MI and that @GENE$-mediated innate immunity is implicated in the pathogenesis of MI.

[ "1" ]

1001

This study has shown that the position of the @GENE$ @DISEASE$ is significantly associated with earlier ESRD and questions whether PKD1 mutations simply inactivate all products of the gene.

[ "0" ]

1002

These data suggest that the R497K polymorphism of the @GENE$, by reducing its activation and a consequential down-regulation of its target genes, could be a key determinant for reduced tumor recurrence of stage II/III @DISEASE$ patients receiving curative surgery and a longer survival of patients with stage II/III as well as metastatic colorectal carcinoma.

[ "1" ]

1003

105V/114V alleles of @GENE$ and 113H/139H alleles of mEPHX and the combination of genotypes with same alleles associated with imbalanced @DISEASE$ and lung function in patients, signifying the importance in the disease.

[ "0" ]

1004

the @GENE$*3 polymorphism may be an important factor in determining the dose requirement for tacrolimus and genotyping can help determine the initial daily dose required by individual patients for adequate @DISEASE$.

[ "0" ]

1005

In conclusion, our results suggest that the @GENE$ gene or other genes in the region may increase the susceptibility to prostate cancer in men; however, the polymorphism in the 5' promoter region has a minor role if any in increasing @DISEASE$ susceptibility in our study sample.

[ "1" ]

1006

While these preliminary findings should be interpreted cautiously, our data suggest that the @GENE$ VNTR polymorphism is associated with measures of @DISEASE$ in a sample of children displaying extreme, persistent and pervasive aggression.

[ "0" ]

1007

(1) DRB1 * 0405 and DRB1 * 15 are closely associated with the susceptibility to @DISEASE$, @GENE$ * 0405 may be the major susceptible gene and DRB1 * 15 may be the minor; (2) DRB1 * 14 and DRB1 * 08 are negatively associated with the susceptibility to VKH syndrome, suggesting that they may be the resistant genes; (3) DRB1 * 0405 is not related to the clinical features, incidence of ocular complications as well as visual prognosis.

[ "1" ]

1008

SNPs in the @GENE$ and @DISEASE$ genes contribute to plasma levels of high-density lipoprotein cholesterol.

[ "0" ]

1009

The M55L and Q192R SNPs of the @GENE$ gene do not appear to be associated with late @DISEASE$ in individuals of Anglo-Celtic descent.

[ "1" ]

1010

We report that rs2918419 was linked with @DISEASE$ and @GENE$ resistance in men.

[ "0" ]

1011

Our results clearly demonstrate that promoter variants associated with @DISEASE$ in humans substantially affect @GENE$ promoter activity in adipocytes.

[ "0" ]

1012

We conclude than In our population, as other worldwide countries, the homozygous for arginine at codon 72 of the @GENE$ gene is not a risk factor to @DISEASE$.

[ "1" ]

1013

The results of our study revealed that HindIII polymorphism of the @GENE$ gene is highly associated with calcium oxalate stone @DISEASE$.

[ "0" ]

1014

Our matched case-control and family study indicate that Cx50, but not @GENE$, may play a role in the genetic susceptibility to @DISEASE$.

[ "0" ]

1015

No significant association between the @GENE$ and HLA-DQ loci and @DISEASE$ in Han nationality in Hunan province was confirmed.

[ "1" ]

1016

Our observations suggest that this polymorphism could play a role in beta-@GENE$ @DISEASE$.

[ "0" ]

1017

CTLA-4 49 AA is protective from @DISEASE$, whereas, @GENE$ 49 G allele (both as homozygotes and as heterozygotes ) confers an increased risk of diabetes mellitus.

[ "1" ]

1018

This study provides the first in vivo evidence of a role for @GENE$ in modifying @DISEASE$ and CHD risk in humans.

[ "0" ]

1019

Our prospective findings suggest that individuals carrying the @GENE$ C282Y mutation may be at increased risk of @DISEASE$.

[ "1" ]

1020

These findings suggest that genetic polymorphisms of @GENE$ are associated with increased risk and a @DISEASE$ free survival of breast cancer in Korean women.

[ "0" ]

1021

In conclusion, the presence of the @GENE$ gene D allele in this sample of normoalbuminuric normotensive Type 1 diabetic patients was associated with a higher proportion of microvascular @DISEASE$ and hypertension.

[ "0" ]

1022

mutations in the @GENE$ gene are only a rare cause of @DISEASE$.

[ "0" ]

1023

We conclude that the strongest association between CTLA4 gene polymorphisms and @DISEASE$ susceptibility occurs with the 3' @GENE$ polymorphism.

[ "0" ]

1024

The @GENE$-3'A allele is associated with a lower presence of subclinical @DISEASE$ in an HIV-infected population.

[ "0" ]

1025

These data suggest that the polymorphisms involved in differences in @GENE$ gene regulation may influence the @DISEASE$ of diabetic vascular complications.

[ "0" ]

1026

@GENE$ 1420C/T genotype could significantly reduce susceptibilities to ESCC and @DISEASE$ among individuals from high risk areas in Hebei Province of China.

[ "0" ]

1027

We can conclude that patients with microsatellite unstable double primary @DISEASE$ of the colorectum and the endometrium have a very high risk of carrying a mutation not only in @GENE$ or MSH2 but also in MSH6, especially if they get their first cancer diagnosis before the age of 50.

[ "0" ]

1028

The @GENE$(-13910) and G/G(-22018) genotype of @DISEASE$ is not associated with susceptibility to the pathogenesis of Crohn disease and ulcerative colitis.

[ "0" ]

1029

The results of our group and from the British and French studies strongly suggest that polymorphisms of the @GENE$ gene do not play a role in susceptibility to @DISEASE$ in European populations.

[ "1" ]

1030

This study establishes that missense, nonsense, @DISEASE$, and splice site mutations of the @GENE$ gene are associated with about half of all malignancies originating from extraadrenal paragangliomas.

[ "0" ]

1031

The results of this study indicate that the missense @DISEASE$ in plasma @GENE$ is associated with development of atherosclerosis in the elderly.

[ "0" ]

1032

Our data suggest that the -344C allele of @GENE$ gene polymorphism is associated with the genetic predisposition to develop @DISEASE$.

[ "1" ]

1033

@GENE$ intron 2 VNTR allele 2 may be a risk indicator for the susceptibility of severe @DISEASE$ in Uighur patients of Xinjiang.

[ "0" ]

1034

It was suggested that @GENE$ gene C677T @DISEASE$ was a possible risk factor of Chinese premature coronary heart disease.

[ "0" ]

1035

The present study suggests that the C-106T polymorphism of the @GENE$ gene could be involved in the early development of @DISEASE$ in Finnish Type 2 diabetic patients.

[ "0" ]

1036

These results indicate that @GENE$ might be a strong candidate for conferring susceptibility to @DISEASE$ across different ethnicities.

[ "1" ]

1037

A higher prevalence of @GENE$-54 @DISEASE$ was found in 5 Chinese nationalities, MBP-54 mutation was not associated with the persistence of hepatitis B.

[ "0" ]

1038

Our results further support the idea that the PROGINS polymorphism of the @GENE$ may be associated with an increased risk of @DISEASE$.

[ "1" ]

1039

There does not appear to be an association of the @GENE$ gene mutation with @DISEASE$ and therefore it is unlikely to be involved in the etiology of IBD.

[ "1" ]

1040

The @GENE$ G2677T and C3435T polymorphisms may help predict the response to radiotherapy in @DISEASE$ patients.

[ "1" ]

1041

Our findings suggest that the 4a allele and the @GENE$ combined genotypes are independent predisposing factors to @DISEASE$.

[ "1" ]

1042

Large genomic rearrangements in @GENE$ are not a common cause of @DISEASE$.

[ "1" ]

1043

Our results suggest that the @GENE$ C677T and MTRR A66G polymorphisms influence the risk of ESCC and @DISEASE$ in this population.

[ "0" ]

1044

Replication of the original @GENE$ findings in these 4 additional asthma populations suggests that this gene (and perhaps others that interact with it) is important in the development and @DISEASE$ of asthma.

[ "0" ]

1045

A strong interaction between SNP309 status and tumor @GENE$ status appears to modify the association between p53 status and @DISEASE$ survival.

[ "1" ]

1046

Our data, therefore, do not support the hypothesis that genetic variation in @GENE$ and COMT is involved individually or in combination in the etiology of @DISEASE$.

[ "1" ]

1047

Our results reveal that the allele @GENE$ is strongly associated with @DISEASE$ but not with withdrawal symptoms or daily alcohol intake.

[ "0" ]

1048

A genetic variant of @GENE$ predisposes patients to @DISEASE$.

[ "0" ]

1049

The data suggest that @GENE$ promoter C+33T polymorphism may be one of the genetic polymorphisms that explain genetic linkage or association between elevated total serum IgE levels and markers on chromosome @DISEASE$.

[ "0" ]

1050

No association was found between the previously implicated polymorphisms of @GENE$, IL-10, CD14 and MnSOD, either individually or simultaneously, and the presence of established @DISEASE$.

[ "0" ]

1051

@GENE$ is not generally associated with T-cell mediated @DISEASE$, although it might play a role in the CD patients with early clinical manifestation.

[ "0" ]

1052

The @GENE$ R219K polymorphism may be involved in the variability of serum HDL-C and the susceptibility to @DISEASE$.

[ "0" ]

1053

After evaluating for the first time the influence of @GENE$ promoter polymorphism in @DISEASE$, it seems to have no major effect on disease susceptibility and/or outcome.

[ "1" ]

1054

The @GENE$ gene may, therefore, be a susceptibility gene in some vitiligo patients, further supporting the epidermal oxidative stress model for @DISEASE$ pathogenesis.

[ "1" ]

1055

These findings indicate that @GENE$ is not a major @DISEASE$ susceptibility gene.

[ "1" ]

1056

there is a statistically significant association between @DISEASE$ and dopamine system genes, especially @GENE$ and DRD5.

[ "1" ]

1057

@GENE$(*)0103 is associated with susceptibility to ulcerative colitis, and IKBL+738(C) marks a propensity to extensive and more severe @DISEASE$.

[ "0" ]

1058

We found no significant association of @DISEASE$ with the trinucleotide repeat polymorphism of the reelin or @GENE$ genes, suggesting that these polymorphisms do not have a major role in the pathogenesis of the disease.

[ "1" ]

1059

These findings show that the C178T(Pro16Ser) variant in @GENE$ may represent a functional variant and affect the susceptibility to @DISEASE$.

[ "1" ]

1060

These results indicate that mutations in NLGN3 and @GENE$ genes are responsible for at most a small fraction of autism cases and additional screenings in other autistic populations are needed to better determine the frequency with which mutations in NLGN3 and NLGN4 occur in @DISEASE$.

[ "1" ]

1061

we report significant association of variants of @GENE$ with ischemic stroke and @DISEASE$ subtypes among whites.

[ "1" ]

1062

These results suggest that there is no overall association between rare alleles of the @GENE$ VNTR and @DISEASE$.

[ "1" ]

1063

The var321 and @DISEASE$(s) in the coding region of the @GENE$ gene probably are a rare cause of TS in a Caucasian population; therefore, genetic heterogeneity of TS should be considered.

[ "0" ]

1064

The @DISEASE$ questionnaire may be used in large-scale epidemiological studies as a surrogate marker of @GENE$ genotype to predict individual cancer risk.

[ "0" ]

1065

A2 allele of the @GENE$ gene is an independent risk factor for LVD @DISEASE$ in males.

[ "1" ]

1066

These findings suggest a potentially important role for the @GENE$ gene in predisposition to @DISEASE$.

[ "1" ]

1067

This observation may imply that the aberrant @GENE$ product has some relation to the development and/or @DISEASE$ of cancers in a variety of human tissues.

[ "0" ]

1068

The @GENE$ polymorphism 25CAG appears to be a new genetic marker for @DISEASE$ susceptibility, at least in Japanese.

[ "1" ]

1069

These results suggest that the high activity @GENE$*1 allozyme protects against dietary and/or environmental chemicals involved in the pathogenesis of @DISEASE$.

[ "1" ]

1070

our data suggests that the A2M D allele is a modest risk factor for late-onset sporadic AD in Koreans, and the @DISEASE$ risk conferred by the @GENE$ D allele increases in APOE epsilon4 negative subjects.

[ "1" ]

1071

Our findings suggest that the variants in @GENE$, or in a nearby gene, may be associated with @DISEASE$ in black men.

[ "1" ]

1072

We can find no genetic influence for these polymorphisms in HLA class I/@GENE$, TNF-alpha/LT-alpha and IL-10 loci on either predisposition or @DISEASE$ in MDS/AML.

[ "0" ]

1073

This study independently verifies the influence of @GENE$ and IDH1 on @DISEASE$ transmission, and its findings suggest that variation in these genes affects susceptibility to HIV infection in exposed individuals.

[ "0" ]

1074

Our study does not support a role of @GENE$ and UGT1A6 genetic variations in the development of @DISEASE$.

[ "0" ]

1075

We found that XPA A23G and XPC Lys939Gln polymorphisms may be risk factors for @DISEASE$ and evidence that positive interactions between the polymorphisms in XPA/XPD and @GENE$/XPD may occur.

[ "1" ]

1076

The results show that @GENE$ I249 is an independent genetic risk factor for coronary artery disease and that CX3CR1 may be involved in the @DISEASE$ of atherosclerotic disease.

[ "0" ]

1077

These data suggest that G1704T and G82S polymorphisms of the @GENE$ gene are not related to @DISEASE$ in Japanese type 2 diabetic patients.

[ "0" ]

1078

@GENE$ * 0301, * 0303 alleles are susceptible alleles, and possibly they are the pathogenic genes, * 0601, * 0602 are resistant alleles, and may be they @DISEASE$ the protective property.

[ "0" ]

1079

Our results do not confirm the association of @GENE$ polymorphism (promoter -159 C to T @DISEASE$) with asthma in Polish children.

[ "0" ]

1080

The @GENE$-Delta32 and CCR2-64I alleles had a strong protective effect on @DISEASE$ of HIV-1 infection, but SDF-1 3'A homozygosity carried no such protection.

[ "0" ]

1081

Our results identify a subgroup of @GENE$ 1 diabetic patients that is sensitive to allelic variation of the negative regulatory molecule CTLA-4 and indicate that TPOAbs testing could be used to subclassify @DISEASE$ patients for inclusion in genetic, biological or clinical studies.

[ "0" ]

1082

In Bangladesh, the @GENE$ N34S @DISEASE$ increases the risk of several forms of pancreatic disease, including fibrocalculous pancreatic diabetes, tropical calcific pancreatitis, and non-insulin-dependent diabetes mellitus.

[ "0" ]

1083

The results indicate that @GENE$*0301 and *0401 alleles are associated with both @DISEASE$ and adenomyosis, and there is perhaps common mechanism involved in both endometriosis and adenomyosis based on HLA-DQA1 and HLA-DRB1 allele frequencies.

[ "0" ]

1084

Our results suggest a potential implication of the @GENE$ -1154 G-->A and -634 G-->C polymorphisms in the development of @DISEASE$ in patients with HSP.

[ "0" ]

1085

Although no association was observed between the @GENE$ promoter polymorphism and coronary in-stent @DISEASE$ following the stent procedure, the association with plasma IL-6 levels suggests that HO-1 S allele might protect from the atherosclerotic inflammatory process.

[ "0" ]

1086

The @GENE$ locus influences susceptibility to @DISEASE$ in our patient group; however, it has no significant effect on the immune response or on the clinical course of the disease.

[ "0" ]

1087

polymorphisms *4, *7 and *9 of @GENE$ were detected in approximately three out of four Japanese smokers, and their daily cigarette @DISEASE$ was genetically modulated by these functional polymorphisms.

[ "0" ]

1088

The data suggest that the polymorphism in exon 10 of the @GENE$ gene may be associated with resistance to oxaliplatin/5-FU chemotherapy in advanced @DISEASE$.

[ "1" ]

1089

Our results suggest that a dysregulation of @GENE$-driven downregulation of T-cell activation could be involved in the pathogenesis of @DISEASE$.

[ "1" ]

1090

Our results provide evidence suggesting that @GENE$ is involved in the @DISEASE$ of OA of the hip.

[ "0" ]

1091

These results suggest that the @GENE$ gene is a target of genomic instability in MSI-positive colorectal cancers and that the Chk1 framshift mutations might be involved in colorectal tumourigenesis through a defect in response to DNA damage in a subset of sporadic @DISEASE$ and HNPCCs.

[ "1" ]

1092

Our data indicate that these @GENE$ polymorphisms have no influence on the incidence, progression and inflammatory parameters of @DISEASE$.

[ "1" ]

1093

@GENE$ TaqIB polymorphism is significantly associated with the presence of AF in the context of micro- or macroalbuminuria, elevated C-reactive protein, renal @DISEASE$, and ischemic heart disease.

[ "0" ]

1094

The Ter447 variant of @GENE$ is associated with decreased risk of brain infarction and @DISEASE$ in our very elderly population.

[ "0" ]

1095

@GENE$ gene C677T @DISEASE$ associated with a predisposition to increased plasma homocysteine levels may represent a genetic risk factor for diabetic nephropathy in Chinese type 2 diabetes mellitus.

[ "0" ]

1096

Our functional and genetic findings identify @GENE$ as an @DISEASE$-susceptibility gene.

[ "1" ]

1097

The @GENE$ Glu298Asp polymorphism does not appear to influence the risk of developing @DISEASE$ in an Italian population.

[ "0" ]

1098

polymorphism in the @GENE$ gene is limited, and although the 1012T genotype appears to influence perforin expression, it was not conclusively associated with disease progression in @DISEASE$.

[ "1" ]

1099

Although variations of the @GENE$ and alpha(1D) genes are not associated with the development of common @DISEASE$, further studies may determine the role of these genomic variations, especially those in the alpha(1D) VDCC gene, in the pathogenesis of certain subsets of type 2 diabetes, or as a co-factor in the polygenic disorder generally.

[ "0" ]