bigbio/gad · Datasets at Hugging Face

id stringlengths 1 4	document_id stringlengths 1 4	text stringlengths 42 538	labels list
3900	3900	Our findings suggest that the @GENE$ his(213) allele is important in the development of @DISEASE$ in men.	[ "1" ]
3901	3901	Although based on a limited number of patients, our work suggests that individuals who are NOS3-CC + @GENE$-DD are at a higher risk for early @DISEASE$, probably as a consequence of increased endothelial dysfunction.	[ "1" ]
3902	3902	We demonstrate that @GENE$ variation and interactive effects play important roles in risk for both @DISEASE$ and AD.	[ "0" ]
3903	3903	The C allele in the @GENE$ gene might be associated with the susceptibility to @DISEASE$ and potentially plays an important role in the manifestation of coronary atherosclerosis among Chinese.	[ "1" ]
3904	3904	These results suggest that polymorphisms in the promoter region of the @GENE$ gene together with the ALR2 may be associated with the @DISEASE$ of diabetic nephropathy.	[ "0" ]
3905	3905	This study shows that the @GENE$ gene promoter polymorphism is a major genetic risk factor modifying the frequency and age-at-onset of @DISEASE$ in SCA patients.	[ "1" ]
3906	3906	Our results correspond to the other studies showing an association between the @GENE$ polymorphism and @DISEASE$ (predominance of the A2 allele in schizophrenic subjects).	[ "0" ]
3907	3907	Our findings suggest that the @GENE$ SNP309 may be a risk factor for the occurrence and advanced neck lymph node metastasis of @DISEASE$ in Chinese population.	[ "1" ]
3908	3908	Our results argue against a specific role for @GENE$ gene deficiency in determining disease susceptibility among patients with @DISEASE$ that are C4-deficient.	[ "1" ]
3909	3909	These results do not support the hypothesis that mutations in @GENE$ are a cause of @DISEASE$ and/or MI but do illustrate general principles regarding the difficulty of connecting genetic variation to common diseases.	[ "0" ]
3910	3910	In conclusion, our findings support the hypothesis that PAT and intron 11 C/A @GENE$ polymorphisms are linked in the Spanish population and may contribute to the risk of developing @DISEASE$ probably due to a higher frequency of deletion of exon 12 and reduced DNA repair capacity of the XPC protein.	[ "1" ]
3911	3911	No association was found between @DISEASE$ susceptibility, course or outcome of the disease, and @GENE$ polymorphisms.	[ "1" ]
3912	3912	Since it is unlikely that TPH polymorphism alters serotonin biosynthesis, its association with @DISEASE$ may be attributed to linkage disequilibrium with a functional variant within the @GENE$ gene or a nearby gene.	[ "1" ]
3913	3913	None of the SNPs of KCNQ1 P448R, KCNQ1 R519H, @GENE$ G643S, KCNE1 G38S and KCNE1 D85N was associated with atrial fibrillation phenotype, but KCNE4 E145D may relation to @DISEASE$.	[ "1" ]
3914	3914	Further studies are needed to determine whether polymorphisms in the @GENE$ gene or other leukotriene-forming enzymes are involved in the @DISEASE$ of the different subsets of NSAID sensitivity.	[ "0" ]
3915	3915	Our results suggest, that the Pl(@GENE$/A1) genotype of Pl(A) GPIIIa polymorphism is associated with more severe @DISEASE$ in male Caucasian patients from the north region of Poland.	[ "0" ]
3916	3916	These results suggest that @GENE$ and transferrin may be part of a complex mechanism in the pathogenesis of @DISEASE$.	[ "1" ]
3917	3917	The present study thus suggest that the variants in the @GENE$ gene may not be major influence of the susceptibility to @DISEASE$ in Finnish and Swedish Caucasians.	[ "1" ]
3918	3918	Our data indicate that @GENE$ gene polymorphism as opposed to the other ethnic groups does not appear to be relevant in @DISEASE$ susceptibility in Mexican patients and that the distribution of the different alleles depend on the frequency of HLA alleles associated with them.	[ "1" ]
3919	3919	Subject to replication, these findings suggest that genetic variation in the @GENE$ gene is associated with susceptibility to @DISEASE$ induced by antipsychotic drugs.	[ "0" ]
3920	3920	The significant association of @GENE$ and IL18 promoter polymorphisms with latex allergy suggests a potential location for genetic control in the induction of latex allergy in individuals and extends the understanding of the genetic basis for the induction of immediate-type @DISEASE$ in healthcare workers occupationally exposed to natural rubber latex.	[ "0" ]
3921	3921	The association found between @GENE$ genotype and risk of MI suggests that TLR4 genetic variants could potentially affect the susceptibility to MI and that TLR4-mediated innate immunity is implicated in the pathogenesis of @DISEASE$.	[ "1" ]
3922	3922	These observations suggest a possible role of @GENE$ in PCG, which might be mediated via digenic interaction with CYP1B1 and/or an yet unidentified locus associated with the @DISEASE$.	[ "0" ]
3923	3923	This study shows that patients with @DISEASE$ have a higher frequency of PLAU T4065C TC genotype and T allele that supports a role of the @GENE$ T4065C polymorphism in determining the risk of MVP among the Chinese population in Taiwan.	[ "1" ]
3924	3924	The @GENE$ K121Q polymorphism is not related to T2DM, features of the @DISEASE$, or diabetic macrovascular complications in a Chinese population.	[ "0" ]
3925	3925	Our results suggest that the presence of the A-AA allele at the @GENE$ promoter region is associated with less aggressive forms of @DISEASE$ and could be looked on as a favorable prognostic factor.	[ "1" ]
3926	3926	There was no relation between @GENE$ gene polymorphism and the TCM genotype of constitution in patients with @DISEASE$.	[ "0" ]
3927	3927	This suggests that genetic variation in the @GENE$ gene may be associated with predisposition to allergic @DISEASE$.	[ "0" ]
3928	3928	We conclude that the described DMB polymorphisms are not associated with @DISEASE$ susceptibility and @GENE$ genotyping is unlikely to improve the assessment of genetic risk for IDDM.	[ "1" ]
3929	3929	The K allele of @GENE$ promoter and TT genotype of TGF-beta1 may be a genetic KLK1 -130 GN and -128 G-C, and the susceptibility factor contributing to progressive renal deterioration in Taiwanese primary @DISEASE$ children.	[ "1" ]
3930	3930	Hence, our data are not in favor of a large effect of @GENE$ gene in the @DISEASE$ of schizophrenia	[ "0" ]
3931	3931	T27796C mutation in @GENE$ is not obviously correlated with @DISEASE$ and this mutation is not associated with categories of stroke.	[ "1" ]
3932	3932	Our results indicate a role of the @GENE$ gene in genetic predisposition of metabolic diseases such as @DISEASE$, type 2 diabetes, and dyslipidemia.	[ "1" ]
3933	3933	Results suggest that @GENE$ low-producer polymorphism and IFN-gamma high-producer polymorphism are associated with @DISEASE$ TB.	[ "0" ]
3934	3934	The results of our @GENE$ study indicate that the GG genotype of the C1542G polymorphism of TAFI displays risk factors for the manifestation of @DISEASE$.	[ "0" ]
3935	3935	Our data do not support the involvement of @GENE$/1D) and 5-HT(2C) receptor gene polymorphisms in @DISEASE$, yet do suggest a possible role for a locus at or near the hSERT gene in the susceptibility to migraine with aura.	[ "1" ]
3936	3936	No association was found between uterine @DISEASE$ and any polymorphisms in the AHRR, @GENE$, ARNT, or CYP1A1 genes analyzed in the present study.	[ "1" ]
3937	3937	These findings indicate that neither the human ITGB7 nor the @GENE$ gene seem to be associated with the pathogenesis of @DISEASE$ or the expression of related allergic phenotypes such as eosinophilia and changes in total IgE level.	[ "1" ]
3938	3938	These results did not support any association of ecNOS and iNOS gene polymorphisms to the development of @GENE$ in @DISEASE$ patients in a Japanese population.	[ "0" ]
3939	3939	@GENE$ polymorphisms may have a significant modifying effect on colorectal cancer risk, which may interact with environmental factors, cigarette smoking and alcohol drinking in colorectal @DISEASE$.	[ "0" ]
3940	3940	Our data indicate that @GENE$ does not contribute substantially to susceptibility to asthma, but it is possible that these polymorphisms influence disease activity and drug responses in individuals with @DISEASE$.	[ "1" ]
3941	3941	The frequency of INSL3/@GENE$ gene mutations as a cause of @DISEASE$ is low, because only 2 of 145 (1.4%) formerly cryptorchid patients were found to have mutations.	[ "1" ]
3942	3942	these results may provide further support for an association between the dysbindin gene (DTNBP1) and @DISEASE$, but not between the disease and DAO, DAOA, @GENE$ and RGS4 or with the interaction of these genes.	[ "1" ]
3943	3943	Given that this study had sufficient power to detect altered risks in the order of 1.4- to 1.7-fold, our results suggest that the @GENE$ (TA)(9) allele is unlikely to be associated with moderate alterations in breast or @DISEASE$ risk.	[ "0" ]
3944	3944	These findings suggest that @GENE$ polymorphism is a potentially effective predictor of @DISEASE$ and may thus be useful for deciding on treatment strategy.	[ "0" ]
3945	3945	The results suggested that both @GENE$ and apoCI on chromosome 19 were the susceptibility locus for @DISEASE$, their linkage disequilibrium should be responsible for the development of CAD.	[ "1" ]
3946	3946	The @GENE$-DQ8 haplotype and the TCR Vbeta5.1(+) CD4(+) T cells may be protective against @DISEASE$ to Can f 1.	[ "0" ]
3947	3947	We have observed evidence consistent with an association between polymorphisms in @GENE$, the human homologue of the Jeff @DISEASE$ gene, and COME/ROM.	[ "0" ]
3948	3948	The frequency of the nonA allele was markedly increased in @GENE$ cases relative to controls (P<0.0005), but this difference was restricted to cases with comorbid @DISEASE$ (P<0.0001) and conduct disorder (P<0.0002), while having little relevance to TS itself.	[ "0" ]
3949	3949	We found no significant association of schizophrenia with the trinucleotide repeat polymorphism of the @GENE$ or VLDLR genes, suggesting that these polymorphisms do not have a major role in the @DISEASE$ of the disease.	[ "0" ]
3950	3950	We conclude that variability at the @GENE$ locus is associated with @DISEASE$ and other features of the insulin resistance syndrome, but given the nature of the two SNPs, the risk haplotype is most probably a marker in linkage disequilibrium with an as yet unidentified polymorphism that affects plasma adiponectin levels and insulin sensitivity.	[ "1" ]
3951	3951	These preliminary results indicate that @GENE$ genotype may influence @DISEASE$ growth in CMM, possibly via the effects of differential VEGF expression on tumour angiogenesis.	[ "0" ]
3952	3952	The results are consistent with the hypothesis that @DISEASE$ in ecstasy users may depend on genetic variation at the @GENE$.	[ "0" ]
3953	3953	Our findings suggest that this @GENE$ promoter polymorphism influences HIV @DISEASE$ by regulating MCP-1 protein expression in the central nervous system (CNS).	[ "0" ]
3954	3954	Common @GENE$ polymorphisms are unlikely to be major determinants of @DISEASE$ in this population.	[ "1" ]
3955	3955	These results are consistent with a gender-specific role of the @GENE$ gene in @DISEASE$ in women.	[ "1" ]
3956	3956	Our results provide evidence of the involvement of @GENE$ as a susceptibility gene for @DISEASE$ in the Japanese population.	[ "1" ]
3957	3957	While independent reproduction of these data in other data sets is indicated, our work is suggestive for a role of the @GENE$ gene in @DISEASE$.	[ "1" ]
3958	3958	These results suggest that the -160 C/A polymorphism of the @GENE$ has no direct effect on the risk of Korean @DISEASE$ development and on its histological classification.	[ "1" ]
3959	3959	We conclude that the described @GENE$ polymorphisms are not associated with @DISEASE$ susceptibility and DMB genotyping is unlikely to improve the assessment of genetic risk for IDDM.	[ "1" ]
3960	3960	The results suggest a possible role of ACE DD genotype as a predisposing factor to AF and a pathophysiological mechanism of @GENE$ inhibition in reducing the incidence of @DISEASE$ in patients with left ventricular dysfunction.	[ "1" ]
3961	3961	Our findings show that the Glu/Asp(298) polymorphism of the @GENE$ gene is associated with @DISEASE$ susceptibility.	[ "1" ]
3962	3962	the G2019S @DISEASE$ in the @GENE$ gene is unlikely to be associated with MSA.	[ "0" ]
3963	3963	the results from our study suggest that the AhR Lys554Arg polymorphism may be a genetic susceptibility factor for breast cancer, whereas @GENE$*1F, which is a potentially functional single nucleotide polymorphism, may not be related to @DISEASE$ risk.	[ "1" ]
3964	3964	These findings suggest a significant involvement of the @GENE$ -1607 1G/2G polymorphism in the increasing risk for @DISEASE$ in the 1G allele European carriers.	[ "1" ]
3965	3965	Our preliminary results raise the concern that the CC genotype of the @GENE$ promoter at -2578 position might be associated with increased risk of renal @DISEASE$ in patients with IgA nephropathy.	[ "0" ]
3966	3966	These results suggest that an expression variant of @GENE$ is a risk factor for human lupus and implicate FCGR2B in @DISEASE$ pathogenesis.	[ "0" ]
3967	3967	These data indicate that the SNP at locus +1239 of @GENE$ gene is associated with @DISEASE$ in elderly patients.	[ "1" ]
3968	3968	The association between the @GENE$ G allele and early RA is largely explained by individuals with RA who have coexisting @DISEASE$ endocrinopathies.	[ "0" ]
3969	3969	We conclude that the @GENE$ 870G > A polymorphism is not associated with @DISEASE$.	[ "1" ]
3970	3970	These findings suggest that @GENE$ -159C/T polymorphism is not related to the development of @DISEASE$ in a Japanese population, but that, within the periodontitis subjects, expression of the SNP may be related to early disease activity.	[ "1" ]
3971	3971	Our study confirms that women heterozygous for @GENE$ have an increased risk of developing @DISEASE$, while the most frequent mutations of the prothrombin and MTHFR gene do not play a major role in the pathogenesis of HELLP syndrome.	[ "0" ]
3972	3972	This study suggests that the @GENE$ gene does not play a major role as a @DISEASE$ susceptibility gene.	[ "1" ]
3973	3973	The single nucleotide polymorphism of @GENE$-31C may contribute to the development of the @DISEASE$ in the H. pylori-positive population.	[ "0" ]
3974	3974	We conclude that alleles of the @GENE$ and TNFalpha genes are unlikely to be of importance for the susceptibility to @DISEASE$, although specific alleles of these genes are often carried on the same haplotype as DR15, DQ6.	[ "1" ]
3975	3975	The total proportion of BMI variance explained by this model was 2.25%, strongly suggesting that @GENE$ genetic variation is a significant determinant of @DISEASE$ in middle-aged males.	[ "0" ]
3976	3976	We conclude that the @GENE$ gene -262C-->T polymorphism does not confer a protective effect with respect to @DISEASE$.	[ "1" ]
3977	3977	This study indicates that the 4G/5G gene polymorphism of @GENE$ is associated with @DISEASE$, that 4G/4G type is probably an important hereditary risk factor, and that glucose has functional importance in regulating PAI-1 activity.	[ "1" ]
3978	3978	Using logistic regression and multiple correlation analysis (MCA), we confirmed that the main risk factor associated and consistently grouped with @DISEASE$ patients in this population is APOE4, but this association was not observed with alleles and genotypes of @GENE$ and A2M.	[ "1" ]
3979	3979	The genetic information about @GENE$ from this study would be useful for further genetic study of @DISEASE$, diabetes, and other metabolic diseases.	[ "1" ]
3980	3980	This finding suggests that no association exists between genetic variation at the @GENE$ locus and @DISEASE$ in Chinese Han males.	[ "1" ]
3981	3981	This cross-sectional study showed a synergistic effect between the intron 4 polymorphism or T(-786)-->C polymorphism of the eNOS gene and the @GENE$ polymorphism with respect to risk for @DISEASE$ in nondiabetic hemodialysis patients.	[ "1" ]
3982	3982	Carriage of the C allele at the @GENE$ + 1580 site is associated with @DISEASE$, septic shock, and the need for mechanical ventilation in adults with community-acquired pneumonia.	[ "0" ]
3983	3983	These data suggest that SNP276 of the @GENE$ gene is not an independent risk factor for @DISEASE$ in Japanese type 2 diabetic patients.	[ "0" ]
3984	3984	There is no association between @GENE$ gene -308 bp polymorphism and the @DISEASE$ of polycystic ovary syndrome, but PCOS patients with TNF2 genotype may associate with improvement to certain degree on abnormal glucose tolerance usually existed in obese PCOS women.	[ "0" ]
3985	3985	fibrinogen @GENE$ and FGA gene haplotypes are not associated with coronary events, @DISEASE$ or extracoronary atherosclerosis.	[ "0" ]
3986	3986	Distinct alleles, genotypes and genotype combinations of @GENE$ and MBL may contribute to differential susceptibility of the host to CCPA or @DISEASE$.	[ "0" ]
3987	3987	Our findings indicate that the @GENE$ Gly972Arg variant does not substantially increase risk of common Type 2 diabetes, or @DISEASE$ in obese persons.	[ "1" ]
3988	3988	It is suggested that @GENE$ profile does not exert an important impact on the influence of tobacco smoking on @DISEASE$ risk.	[ "0" ]
3989	3989	These findings exclude a strong or independent influence of @GENE$ or APOC1 promoter polymorphisms on the variation in APOE-related risk of @DISEASE$ in African American and Caribbean Hispanic individuals.	[ "1" ]
3990	3990	In conclusion, the gain-of-function @DISEASE$ at -401 of @GENE$ promoter is associated with sensitization to cat and mold allergens and FEV1 in Chinese children.	[ "0" ]
3991	3991	The presence of the C allele in the -174 position in the gene coding for @GENE$ could play a role in the @DISEASE$ of neonatal infection following IAI in the mother and probably is connected with decreased of immunological reaction.	[ "0" ]
3992	3992	We found evidence for association between @GENE$ and COGA alcohol dependence, history of @DISEASE$, age at first drunkenness, and level of response to alcohol.	[ "0" ]
3993	3993	APOE and @GENE$ have little or no effect on the clinical outcome of @DISEASE$.	[ "1" ]
3994	3994	the @GENE$-1131T>C SNP, which is present in approximately 13% of this population, modulates the effect of fat intake on BMI and @DISEASE$ risk in both men and women.	[ "0" ]
3995	3995	These data suggest a role for @GENE$, the rate-limiting enzyme in the catabolism of polyamines, in @DISEASE$ and a role for the SSAT342 locus in the regulation of SSAT gene expression.	[ "0" ]
3996	3996	This direct replication of haplotype association in a second population further implicates @GENE$ as a factor that contributes to the etiology of @DISEASE$.	[ "1" ]
3997	3997	The @GENE$ +49G/A and CT60 haplotypes are associated with susceptibility to primary @DISEASE$ and with some extraglandular manifestations of the disease.	[ "0" ]
3998	3998	Therefore, @GENE$ and RNASEL may play a role in @DISEASE$ progression and severity.	[ "1" ]
3999	3999	These observations of higher frequency of the 5-HTTLPR S allele in subjects with past/present depression fit with previous findings and point to the important role of @GENE$ in @DISEASE$.	[ "1" ]

3900

Our findings suggest that the @GENE$ his(213) allele is important in the development of @DISEASE$ in men.

[ "1" ]

3901

Although based on a limited number of patients, our work suggests that individuals who are NOS3-CC + @GENE$-DD are at a higher risk for early @DISEASE$, probably as a consequence of increased endothelial dysfunction.

[ "1" ]

3902

We demonstrate that @GENE$ variation and interactive effects play important roles in risk for both @DISEASE$ and AD.

[ "0" ]

3903

The C allele in the @GENE$ gene might be associated with the susceptibility to @DISEASE$ and potentially plays an important role in the manifestation of coronary atherosclerosis among Chinese.

[ "1" ]

3904

These results suggest that polymorphisms in the promoter region of the @GENE$ gene together with the ALR2 may be associated with the @DISEASE$ of diabetic nephropathy.

[ "0" ]

3905

This study shows that the @GENE$ gene promoter polymorphism is a major genetic risk factor modifying the frequency and age-at-onset of @DISEASE$ in SCA patients.

[ "1" ]

3906

Our results correspond to the other studies showing an association between the @GENE$ polymorphism and @DISEASE$ (predominance of the A2 allele in schizophrenic subjects).

[ "0" ]

3907

Our findings suggest that the @GENE$ SNP309 may be a risk factor for the occurrence and advanced neck lymph node metastasis of @DISEASE$ in Chinese population.

[ "1" ]

3908

Our results argue against a specific role for @GENE$ gene deficiency in determining disease susceptibility among patients with @DISEASE$ that are C4-deficient.

[ "1" ]

3909

These results do not support the hypothesis that mutations in @GENE$ are a cause of @DISEASE$ and/or MI but do illustrate general principles regarding the difficulty of connecting genetic variation to common diseases.

[ "0" ]

3910

In conclusion, our findings support the hypothesis that PAT and intron 11 C/A @GENE$ polymorphisms are linked in the Spanish population and may contribute to the risk of developing @DISEASE$ probably due to a higher frequency of deletion of exon 12 and reduced DNA repair capacity of the XPC protein.

[ "1" ]

3911

No association was found between @DISEASE$ susceptibility, course or outcome of the disease, and @GENE$ polymorphisms.

[ "1" ]

3912

Since it is unlikely that TPH polymorphism alters serotonin biosynthesis, its association with @DISEASE$ may be attributed to linkage disequilibrium with a functional variant within the @GENE$ gene or a nearby gene.

[ "1" ]

3913

None of the SNPs of KCNQ1 P448R, KCNQ1 R519H, @GENE$ G643S, KCNE1 G38S and KCNE1 D85N was associated with atrial fibrillation phenotype, but KCNE4 E145D may relation to @DISEASE$.

[ "1" ]

3914

Further studies are needed to determine whether polymorphisms in the @GENE$ gene or other leukotriene-forming enzymes are involved in the @DISEASE$ of the different subsets of NSAID sensitivity.

[ "0" ]

3915

Our results suggest, that the Pl(@GENE$/A1) genotype of Pl(A) GPIIIa polymorphism is associated with more severe @DISEASE$ in male Caucasian patients from the north region of Poland.

[ "0" ]

3916

These results suggest that @GENE$ and transferrin may be part of a complex mechanism in the pathogenesis of @DISEASE$.

[ "1" ]

3917

The present study thus suggest that the variants in the @GENE$ gene may not be major influence of the susceptibility to @DISEASE$ in Finnish and Swedish Caucasians.

[ "1" ]

3918

Our data indicate that @GENE$ gene polymorphism as opposed to the other ethnic groups does not appear to be relevant in @DISEASE$ susceptibility in Mexican patients and that the distribution of the different alleles depend on the frequency of HLA alleles associated with them.

[ "1" ]

3919

Subject to replication, these findings suggest that genetic variation in the @GENE$ gene is associated with susceptibility to @DISEASE$ induced by antipsychotic drugs.

[ "0" ]

3920

The significant association of @GENE$ and IL18 promoter polymorphisms with latex allergy suggests a potential location for genetic control in the induction of latex allergy in individuals and extends the understanding of the genetic basis for the induction of immediate-type @DISEASE$ in healthcare workers occupationally exposed to natural rubber latex.

[ "0" ]

3921

The association found between @GENE$ genotype and risk of MI suggests that TLR4 genetic variants could potentially affect the susceptibility to MI and that TLR4-mediated innate immunity is implicated in the pathogenesis of @DISEASE$.

[ "1" ]

3922

These observations suggest a possible role of @GENE$ in PCG, which might be mediated via digenic interaction with CYP1B1 and/or an yet unidentified locus associated with the @DISEASE$.

[ "0" ]

3923

This study shows that patients with @DISEASE$ have a higher frequency of PLAU T4065C TC genotype and T allele that supports a role of the @GENE$ T4065C polymorphism in determining the risk of MVP among the Chinese population in Taiwan.

[ "1" ]

3924

The @GENE$ K121Q polymorphism is not related to T2DM, features of the @DISEASE$, or diabetic macrovascular complications in a Chinese population.

[ "0" ]

3925

Our results suggest that the presence of the A-AA allele at the @GENE$ promoter region is associated with less aggressive forms of @DISEASE$ and could be looked on as a favorable prognostic factor.

[ "1" ]

3926

There was no relation between @GENE$ gene polymorphism and the TCM genotype of constitution in patients with @DISEASE$.

[ "0" ]

3927

This suggests that genetic variation in the @GENE$ gene may be associated with predisposition to allergic @DISEASE$.

[ "0" ]

3928

We conclude that the described DMB polymorphisms are not associated with @DISEASE$ susceptibility and @GENE$ genotyping is unlikely to improve the assessment of genetic risk for IDDM.

[ "1" ]

3929

The K allele of @GENE$ promoter and TT genotype of TGF-beta1 may be a genetic KLK1 -130 GN and -128 G-C, and the susceptibility factor contributing to progressive renal deterioration in Taiwanese primary @DISEASE$ children.

[ "1" ]

3930

Hence, our data are not in favor of a large effect of @GENE$ gene in the @DISEASE$ of schizophrenia

[ "0" ]

3931

T27796C mutation in @GENE$ is not obviously correlated with @DISEASE$ and this mutation is not associated with categories of stroke.

[ "1" ]

3932

Our results indicate a role of the @GENE$ gene in genetic predisposition of metabolic diseases such as @DISEASE$, type 2 diabetes, and dyslipidemia.

[ "1" ]

3933

Results suggest that @GENE$ low-producer polymorphism and IFN-gamma high-producer polymorphism are associated with @DISEASE$ TB.

[ "0" ]

3934

The results of our @GENE$ study indicate that the GG genotype of the C1542G polymorphism of TAFI displays risk factors for the manifestation of @DISEASE$.

[ "0" ]

3935

Our data do not support the involvement of @GENE$/1D) and 5-HT(2C) receptor gene polymorphisms in @DISEASE$, yet do suggest a possible role for a locus at or near the hSERT gene in the susceptibility to migraine with aura.

[ "1" ]

3936

No association was found between uterine @DISEASE$ and any polymorphisms in the AHRR, @GENE$, ARNT, or CYP1A1 genes analyzed in the present study.

[ "1" ]

3937

These findings indicate that neither the human ITGB7 nor the @GENE$ gene seem to be associated with the pathogenesis of @DISEASE$ or the expression of related allergic phenotypes such as eosinophilia and changes in total IgE level.

[ "1" ]

3938

These results did not support any association of ecNOS and iNOS gene polymorphisms to the development of @GENE$ in @DISEASE$ patients in a Japanese population.

[ "0" ]

3939

@GENE$ polymorphisms may have a significant modifying effect on colorectal cancer risk, which may interact with environmental factors, cigarette smoking and alcohol drinking in colorectal @DISEASE$.

[ "0" ]

3940

Our data indicate that @GENE$ does not contribute substantially to susceptibility to asthma, but it is possible that these polymorphisms influence disease activity and drug responses in individuals with @DISEASE$.

[ "1" ]

3941

The frequency of INSL3/@GENE$ gene mutations as a cause of @DISEASE$ is low, because only 2 of 145 (1.4%) formerly cryptorchid patients were found to have mutations.

[ "1" ]

3942

these results may provide further support for an association between the dysbindin gene (DTNBP1) and @DISEASE$, but not between the disease and DAO, DAOA, @GENE$ and RGS4 or with the interaction of these genes.

[ "1" ]

3943

Given that this study had sufficient power to detect altered risks in the order of 1.4- to 1.7-fold, our results suggest that the @GENE$ (TA)(9) allele is unlikely to be associated with moderate alterations in breast or @DISEASE$ risk.

[ "0" ]

3944

These findings suggest that @GENE$ polymorphism is a potentially effective predictor of @DISEASE$ and may thus be useful for deciding on treatment strategy.

[ "0" ]

3945

The results suggested that both @GENE$ and apoCI on chromosome 19 were the susceptibility locus for @DISEASE$, their linkage disequilibrium should be responsible for the development of CAD.

[ "1" ]

3946

The @GENE$-DQ8 haplotype and the TCR Vbeta5.1(+) CD4(+) T cells may be protective against @DISEASE$ to Can f 1.

[ "0" ]

3947

We have observed evidence consistent with an association between polymorphisms in @GENE$, the human homologue of the Jeff @DISEASE$ gene, and COME/ROM.

[ "0" ]

3948

The frequency of the nonA allele was markedly increased in @GENE$ cases relative to controls (P<0.0005), but this difference was restricted to cases with comorbid @DISEASE$ (P<0.0001) and conduct disorder (P<0.0002), while having little relevance to TS itself.

[ "0" ]

3949

We found no significant association of schizophrenia with the trinucleotide repeat polymorphism of the @GENE$ or VLDLR genes, suggesting that these polymorphisms do not have a major role in the @DISEASE$ of the disease.

[ "0" ]

3950

We conclude that variability at the @GENE$ locus is associated with @DISEASE$ and other features of the insulin resistance syndrome, but given the nature of the two SNPs, the risk haplotype is most probably a marker in linkage disequilibrium with an as yet unidentified polymorphism that affects plasma adiponectin levels and insulin sensitivity.

[ "1" ]

3951

These preliminary results indicate that @GENE$ genotype may influence @DISEASE$ growth in CMM, possibly via the effects of differential VEGF expression on tumour angiogenesis.

[ "0" ]

3952

The results are consistent with the hypothesis that @DISEASE$ in ecstasy users may depend on genetic variation at the @GENE$.

[ "0" ]

3953

Our findings suggest that this @GENE$ promoter polymorphism influences HIV @DISEASE$ by regulating MCP-1 protein expression in the central nervous system (CNS).

[ "0" ]

3954

Common @GENE$ polymorphisms are unlikely to be major determinants of @DISEASE$ in this population.

[ "1" ]

3955

These results are consistent with a gender-specific role of the @GENE$ gene in @DISEASE$ in women.

[ "1" ]

3956

Our results provide evidence of the involvement of @GENE$ as a susceptibility gene for @DISEASE$ in the Japanese population.

[ "1" ]

3957

While independent reproduction of these data in other data sets is indicated, our work is suggestive for a role of the @GENE$ gene in @DISEASE$.

[ "1" ]

3958

These results suggest that the -160 C/A polymorphism of the @GENE$ has no direct effect on the risk of Korean @DISEASE$ development and on its histological classification.

[ "1" ]

3959

We conclude that the described @GENE$ polymorphisms are not associated with @DISEASE$ susceptibility and DMB genotyping is unlikely to improve the assessment of genetic risk for IDDM.

[ "1" ]

3960

The results suggest a possible role of ACE DD genotype as a predisposing factor to AF and a pathophysiological mechanism of @GENE$ inhibition in reducing the incidence of @DISEASE$ in patients with left ventricular dysfunction.

[ "1" ]

3961

Our findings show that the Glu/Asp(298) polymorphism of the @GENE$ gene is associated with @DISEASE$ susceptibility.

[ "1" ]

3962

the G2019S @DISEASE$ in the @GENE$ gene is unlikely to be associated with MSA.

[ "0" ]

3963

the results from our study suggest that the AhR Lys554Arg polymorphism may be a genetic susceptibility factor for breast cancer, whereas @GENE$*1F, which is a potentially functional single nucleotide polymorphism, may not be related to @DISEASE$ risk.

[ "1" ]

3964

These findings suggest a significant involvement of the @GENE$ -1607 1G/2G polymorphism in the increasing risk for @DISEASE$ in the 1G allele European carriers.

[ "1" ]

3965

Our preliminary results raise the concern that the CC genotype of the @GENE$ promoter at -2578 position might be associated with increased risk of renal @DISEASE$ in patients with IgA nephropathy.

[ "0" ]

3966

These results suggest that an expression variant of @GENE$ is a risk factor for human lupus and implicate FCGR2B in @DISEASE$ pathogenesis.

[ "0" ]

3967

These data indicate that the SNP at locus +1239 of @GENE$ gene is associated with @DISEASE$ in elderly patients.

[ "1" ]

3968

The association between the @GENE$ G allele and early RA is largely explained by individuals with RA who have coexisting @DISEASE$ endocrinopathies.

[ "0" ]

3969

We conclude that the @GENE$ 870G > A polymorphism is not associated with @DISEASE$.

[ "1" ]

3970

These findings suggest that @GENE$ -159C/T polymorphism is not related to the development of @DISEASE$ in a Japanese population, but that, within the periodontitis subjects, expression of the SNP may be related to early disease activity.

[ "1" ]

3971

Our study confirms that women heterozygous for @GENE$ have an increased risk of developing @DISEASE$, while the most frequent mutations of the prothrombin and MTHFR gene do not play a major role in the pathogenesis of HELLP syndrome.

[ "0" ]

3972

This study suggests that the @GENE$ gene does not play a major role as a @DISEASE$ susceptibility gene.

[ "1" ]

3973

The single nucleotide polymorphism of @GENE$-31C may contribute to the development of the @DISEASE$ in the H. pylori-positive population.

[ "0" ]

3974

We conclude that alleles of the @GENE$ and TNFalpha genes are unlikely to be of importance for the susceptibility to @DISEASE$, although specific alleles of these genes are often carried on the same haplotype as DR15, DQ6.

[ "1" ]

3975

The total proportion of BMI variance explained by this model was 2.25%, strongly suggesting that @GENE$ genetic variation is a significant determinant of @DISEASE$ in middle-aged males.

[ "0" ]

3976

We conclude that the @GENE$ gene -262C-->T polymorphism does not confer a protective effect with respect to @DISEASE$.

[ "1" ]

3977

This study indicates that the 4G/5G gene polymorphism of @GENE$ is associated with @DISEASE$, that 4G/4G type is probably an important hereditary risk factor, and that glucose has functional importance in regulating PAI-1 activity.

[ "1" ]

3978

Using logistic regression and multiple correlation analysis (MCA), we confirmed that the main risk factor associated and consistently grouped with @DISEASE$ patients in this population is APOE4, but this association was not observed with alleles and genotypes of @GENE$ and A2M.

[ "1" ]

3979

The genetic information about @GENE$ from this study would be useful for further genetic study of @DISEASE$, diabetes, and other metabolic diseases.

[ "1" ]

3980

This finding suggests that no association exists between genetic variation at the @GENE$ locus and @DISEASE$ in Chinese Han males.

[ "1" ]

3981

This cross-sectional study showed a synergistic effect between the intron 4 polymorphism or T(-786)-->C polymorphism of the eNOS gene and the @GENE$ polymorphism with respect to risk for @DISEASE$ in nondiabetic hemodialysis patients.

[ "1" ]

3982

Carriage of the C allele at the @GENE$ + 1580 site is associated with @DISEASE$, septic shock, and the need for mechanical ventilation in adults with community-acquired pneumonia.

[ "0" ]

3983

These data suggest that SNP276 of the @GENE$ gene is not an independent risk factor for @DISEASE$ in Japanese type 2 diabetic patients.

[ "0" ]

3984

There is no association between @GENE$ gene -308 bp polymorphism and the @DISEASE$ of polycystic ovary syndrome, but PCOS patients with TNF2 genotype may associate with improvement to certain degree on abnormal glucose tolerance usually existed in obese PCOS women.

[ "0" ]

3985

fibrinogen @GENE$ and FGA gene haplotypes are not associated with coronary events, @DISEASE$ or extracoronary atherosclerosis.

[ "0" ]

3986

Distinct alleles, genotypes and genotype combinations of @GENE$ and MBL may contribute to differential susceptibility of the host to CCPA or @DISEASE$.

[ "0" ]

3987

Our findings indicate that the @GENE$ Gly972Arg variant does not substantially increase risk of common Type 2 diabetes, or @DISEASE$ in obese persons.

[ "1" ]

3988

It is suggested that @GENE$ profile does not exert an important impact on the influence of tobacco smoking on @DISEASE$ risk.

[ "0" ]

3989

These findings exclude a strong or independent influence of @GENE$ or APOC1 promoter polymorphisms on the variation in APOE-related risk of @DISEASE$ in African American and Caribbean Hispanic individuals.

[ "1" ]

3990

In conclusion, the gain-of-function @DISEASE$ at -401 of @GENE$ promoter is associated with sensitization to cat and mold allergens and FEV1 in Chinese children.

[ "0" ]

3991

The presence of the C allele in the -174 position in the gene coding for @GENE$ could play a role in the @DISEASE$ of neonatal infection following IAI in the mother and probably is connected with decreased of immunological reaction.

[ "0" ]

3992

We found evidence for association between @GENE$ and COGA alcohol dependence, history of @DISEASE$, age at first drunkenness, and level of response to alcohol.

[ "0" ]

3993

APOE and @GENE$ have little or no effect on the clinical outcome of @DISEASE$.

[ "1" ]

3994

the @GENE$-1131T>C SNP, which is present in approximately 13% of this population, modulates the effect of fat intake on BMI and @DISEASE$ risk in both men and women.

[ "0" ]

3995

These data suggest a role for @GENE$, the rate-limiting enzyme in the catabolism of polyamines, in @DISEASE$ and a role for the SSAT342 locus in the regulation of SSAT gene expression.

[ "0" ]

3996

This direct replication of haplotype association in a second population further implicates @GENE$ as a factor that contributes to the etiology of @DISEASE$.

[ "1" ]

3997

The @GENE$ +49G/A and CT60 haplotypes are associated with susceptibility to primary @DISEASE$ and with some extraglandular manifestations of the disease.

[ "0" ]

3998

Therefore, @GENE$ and RNASEL may play a role in @DISEASE$ progression and severity.

[ "1" ]

3999

These observations of higher frequency of the 5-HTTLPR S allele in subjects with past/present depression fit with previous findings and point to the important role of @GENE$ in @DISEASE$.

[ "1" ]