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4000 | 4000 | Since none of the remaining @GENE$*04 subtypes was associated with type 1 DM, our study may present another piece of evidence that the DRB1*0401 and DRB1*0404 alleles do not modify @DISEASE$ risk generally in European populations. | [
"1"
] |
4001 | 4001 | Early age at onset may be a good predictor of @GENE$ @DISEASE$ in Liguria, where the G101W founder mutation is prevalent among melanoma patients, independent of family history. | [
"0"
] |
4002 | 4002 | @GENE$ and NPHP6 are major genes of @DISEASE$ associated with JS. | [
"0"
] |
4003 | 4003 | there is only a @DISEASE$ association of one SNP in @GENE$ with schizophrenia, which is not significant after multiple testing. | [
"0"
] |
4004 | 4004 | Our results suggest that @GENE$ is unlikely to play a major role in the genetic predisposition to @DISEASE$ in the German or the Palestinian-Arab population. | [
"1"
] |
4005 | 4005 | The results showed that frequencies of the genotype 86/86 and of the allele 86 were significantly decreased in MM and @DISEASE$ compared with matched healthy controls, indicating that the @GENE$ microsatellite polymorphism might represent a susceptibility locus for MM and MGUS. | [
"0"
] |
4006 | 4006 | Our preliminary results raise the concern that the CC genotype of the @GENE$ promoter at -2578 position might be associated with increased risk of renal progression in patients with @DISEASE$. | [
"1"
] |
4007 | 4007 | In addition to the @GENE$ (ACE) and angiotensinogen (AGT) gene variants, gene-gene interactions may be important causative factors in a complex @DISEASE$ such as young-onset essential hypertension. | [
"0"
] |
4008 | 4008 | Although rs7566605 was not significantly associated with @DISEASE$ in our study population, we can not rule out the involvement of INSIG2 in obesity related traits as we found significant association of another tagSNP in @GENE$ with both BMI and ABDCIR. | [
"1"
] |
4009 | 4009 | Common polymorphisms within EPHX1 and @GENE$ do not appear to be important risk factors for @DISEASE$. | [
"1"
] |
4010 | 4010 | (1) DRB1 * 0405 and DRB1 * 15 are closely associated with the susceptibility to VKH syndrome, DRB1 * 0405 may be the major susceptible gene and DRB1 * 15 may be the minor; (2) DRB1 * 14 and @GENE$ * 08 are negatively associated with the susceptibility to @DISEASE$, suggesting that they may be the resistant genes; (3) DRB1 * 0405 is not related to the clinical features, incidence of ocular complications as well as visual prognosis. | [
"1"
] |
4011 | 4011 | These studies suggest functional differences of @GENE$ haplotypes in human energy metabolism and support a role of PPARGC1 in @DISEASE$. | [
"1"
] |
4012 | 4012 | @GENE$ genes may not play a role in the carcinogenesis of @DISEASE$. | [
"1"
] |
4013 | 4013 | The R121W @DISEASE$ in @GENE$ is a predisposing factor for the development of type 2 diabetes in Okinawans. | [
"0"
] |
4014 | 4014 | For patients with heart failure caused by systolic function, the Asp298 variant of @GENE$ is associated with poorer event-free survival, particularly in patients with nonischemic @DISEASE$. | [
"0"
] |
4015 | 4015 | These results suggest no major modifying role for the Mn-@GENE$ gene polymorphism in patients with @DISEASE$. | [
"0"
] |
4016 | 4016 | Despite the strikingly similar pathologies of @GENE$ syndrome and @DISEASE$, no mutations were found to be associated with sarcoidosis in a group of patients, regardless of the presence of uveitis. | [
"1"
] |
4017 | 4017 | Our findings argue against an important predisposing effect of the @GENE$ and CDKN2A genes for @DISEASE$. | [
"1"
] |
4018 | 4018 | In conclusion, our results do not support the prevailing notion that sequence variation in the @GENE$ gene is a frequent cause of human @DISEASE$. | [
"1"
] |
4019 | 4019 | This @DISEASE$ suggests that polymorphisms in @GENE$ confer general risk to develop autoimmunity and identifies a potential therapeutic target in the prevention of autoimmune endocrine disorders. | [
"0"
] |
4020 | 4020 | Some cases of @DISEASE$ and @GENE$ could share a functionally significant polymorphism in the Sp1 transcription factor binding site in the first intron of the COL1A1 gene. | [
"0"
] |
4021 | 4021 | Our results show that the C1773 mutant of @GENE$ increases susceptibility to @DISEASE$, but not via hypercholesterolaemia. | [
"1"
] |
4022 | 4022 | Polymorphism of @GENE$ is not an inherited risk factor and is not associated with Chinese arterial thrombotic @DISEASE$, such as AMI and AIS. | [
"0"
] |
4023 | 4023 | The @GENE$ gene is less likely to play a substantial role in the development of atopy and @DISEASE$ in the Japanese population. | [
"1"
] |
4024 | 4024 | @GENE$ genotypes and haplotypes impact HIV-1 @DISEASE$ independently of CD4+ lymphocyte count and plasma HIV-1 RNA load, suggesting that the fundamental role of CX3CR1 in the alteration of disease progression might be the recruitment of immunomodulatory cells responsible for the control of HIV-1. | [
"0"
] |
4025 | 4025 | Our data suggest that potassium should be monitored with particular caution when spironolactone is started in patients with @DISEASE$ who have evidence of elevated aldosterone levels, such as high diuretic requirements, or the @GENE$ 215G allele. | [
"0"
] |
4026 | 4026 | In conclusion, carriage of the @GENE$*3 allele, as well as variant-211 UGT1A1 allele represents a risk factor for the development of, and a determinant for, metastases associated with @DISEASE$ patients. | [
"1"
] |
4027 | 4027 | The results do not support a major role for @GENE$ D repeat polymorphism in the susceptibility to @DISEASE$. | [
"1"
] |
4028 | 4028 | Our findings suggest that, among Japanese, the -28G allele of the @GENE$ promoter region confers susceptibility to @DISEASE$. | [
"0"
] |
4029 | 4029 | The PD-1 gene is significantly associated with RA susceptibility, suggesting the possibility that @GENE$ may contribute to the pathogenesis of @DISEASE$. | [
"1"
] |
4030 | 4030 | These results suggested that among IFNG and related genes, IFNG and @GENE$ genes confer genetic susceptibility to @DISEASE$ in Japanese children. | [
"0"
] |
4031 | 4031 | The 2G or 1G SNP in the @GENE$ promoter might not modify the risk of ESCC and @DISEASE$ development and might not be used as a stratification marker to predict the potential of lymphatic metastasis in these two tumor types. | [
"0"
] |
4032 | 4032 | These results show that the reduced renal excretion of uric acid in patients with @DISEASE$ is mediated by high levels of VLDL and by the high prevalence of the @GENE$ allele of apolipoprotein E. | [
"0"
] |
4033 | 4033 | Our findings suggest that the @GENE$ gene cluster polymorphisms may play a significant role in the pathogenesis of @DISEASE$ of the hip. | [
"1"
] |
4034 | 4034 | Our findings demonstrate that carriage of the low-activity S allele is associated with extremely @DISEASE$ criminal behavior in Chinese males, and suggests that the @GENE$ may be implicated in the mechanisms underlying violent behaviors. | [
"0"
] |
4035 | 4035 | The results from this study suggest that homozygosity for the @GENE$ His213 allele may be a risk factor for @DISEASE$, and its effect may be modified by the exposure level of endogenous estrogens and heterocyclic amines. | [
"1"
] |
4036 | 4036 | Our results suggest that the @GENE$ gene may play a @DISEASE$ role in the overall genetic predisposition to type 1 diabetes in this UK population. | [
"0"
] |
4037 | 4037 | Our data do not support an association of common variants in @GENE$ with @DISEASE$ in populations of European descent. | [
"1"
] |
4038 | 4038 | @GENE$ 49 AA is protective from @DISEASE$, whereas, CTLA-4 49 G allele (both as homozygotes and as heterozygotes ) confers an increased risk of diabetes mellitus. | [
"1"
] |
4039 | 4039 | In conclusion, our data suggest that @GENE$ polymorphism is a genetic modifier of the progression of @DISEASE$, possibly through inducing a partial defect in PD-1-mediated inhibition of T-cell activation. | [
"1"
] |
4040 | 4040 | Together, our findings suggest that the presence of @GENE$ gene polymorphisms may be inconclusive in the susceptibility to MS or in the clinical characteristics of Japanese patients with @DISEASE$ and, therefore, need further studies. | [
"1"
] |
4041 | 4041 | The observed genotype data in subjects from eastern Finland suggest that the Glu298Asp polymorphism of the @GENE$ gene does not contribute to @DISEASE$ in this population. | [
"1"
] |
4042 | 4042 | The @GENE$ promoter polymorphism, rs11200638, is a strong candidate with a functional consequence that predisposes Japanese to develop neovascular @DISEASE$. | [
"0"
] |
4043 | 4043 | Plasma @GENE$ is associated with @DISEASE$ by participating in the development of IR. | [
"0"
] |
4044 | 4044 | Coupled with previous findings, our data suggest that heritable @GENE$ and IL10 variations may contribute to the acquisition or progression of @DISEASE$ and that the effects of other targeted loci in the cytokine and chemokine system cannot be established unequivocally in the study populations. | [
"1"
] |
4045 | 4045 | These results imply that @GENE$(GT) genotype is associated with the @DISEASE$ of type 2 DN in Korean patients. | [
"0"
] |
4046 | 4046 | The lack of association between @GENE$ genotypes and IgE as well as @DISEASE$ outcomes in this large German study population seems to indicate that CD14 genotypes may not directly be involved in the development of allergies during childhood. | [
"1"
] |
4047 | 4047 | @GENE$ His allele is positively associated with the risk of @DISEASE$, and an interaction exist between this allele and related exposure factors. | [
"1"
] |
4048 | 4048 | The @GENE$ PlA1/A2 polymorphism is not associated with @DISEASE$, glucose metabolism, angiographic CHD or myocardial infarction. | [
"0"
] |
4049 | 4049 | Mutations in the @GENE$ gene are not a common cause of @DISEASE$. | [
"1"
] |
4050 | 4050 | Thus, variation in the @GENE$ gene may affect risk of @DISEASE$ in Japanese, especially in older individuals. | [
"1"
] |
4051 | 4051 | Our study implies that the G/C polymorphism of the @GENE$ gene may not be directly involved in the development and=or progression of @DISEASE$. | [
"1"
] |
4052 | 4052 | It is also concluded that CHEK2 protein abrogation is not caused by the @GENE$ germline variants R117G, R137Q, R145W, I157T, and R180H in familial @DISEASE$. | [
"1"
] |
4053 | 4053 | The results show that @GENE$ I249 is an independent genetic risk factor for @DISEASE$ and that CX3CR1 may be involved in the pathogenesis of atherosclerotic disease. | [
"1"
] |
4054 | 4054 | These results suggest that the @GENE$ - 3'A and CCR2b-V64I mutations do not affect the course of HCV and @DISEASE$/HCV infection in the same manner as does the CCR5-Delta32 mutation. | [
"0"
] |
4055 | 4055 | These findings show no evidence for association between @GENE$ intron 6 BamHI polymorphism and @DISEASE$ in our population. | [
"1"
] |
4056 | 4056 | common African @GENE$ and -DQB1 variants, previously associated with protection from @DISEASE$ and hepatitis B/C virus persistence, predispose the Venda to TB, whereas the proposedly active VDR haplotype F-b-A-T showed significant protection. | [
"0"
] |
4057 | 4057 | It is possible that the association seen in other studies may be due to population stratification or to the @GENE$ polymorphism being in linkage with the real @DISEASE$-causing variant(s). | [
"0"
] |
4058 | 4058 | our LD analysis did not reveal any association between @DISEASE$ in our Han Chinese population and the @GENE$ gene or its partially duplicated region. | [
"1"
] |
4059 | 4059 | We conclude that long apoB 3' VNTR alleles occur more frequently in @DISEASE$ patients, but that @GENE$ 3'VNTR genotypic variation has little impact on the risk of dyslipidemia in Taiwanese. | [
"1"
] |
4060 | 4060 | Our findings are consistent with a prior report that the Arg/His polymorphism in @GENE$ is associated with @DISEASE$ risk. | [
"1"
] |
4061 | 4061 | We conclude that carriers of N291S or combined D9N/ - 93T --> G mutations in the @GENE$ gene are at substantially increased risk of @DISEASE$. | [
"1"
] |
4062 | 4062 | Therefore, in this present study, we find no evidence for the involvement of these @GENE$ polymorphisms in increasing susceptibility to @DISEASE$. | [
"1"
] |
4063 | 4063 | suggest the existence of genetic susceptibility for @DISEASE$ in carriers of this @GENE$ functional polymorphism. | [
"1"
] |
4064 | 4064 | Deteriorating gallbladder contractions, possibly induced by alterations in the CCK-AR gene, as well as @GENE$ gene polymorphism, promoted @DISEASE$ formation. | [
"1"
] |
4065 | 4065 | These data do not support a substantial association between common genetic variation in @GENE$ and @DISEASE$ risk. | [
"1"
] |
4066 | 4066 | We conclude that heavy proteinuria itself may accelerate the @DISEASE$ of @GENE$ by increasing the MCP-1 expression in renal tubuli. | [
"0"
] |
4067 | 4067 | S Association with @GENE$, as well as that previously reported with T1D, suggests that the CD25 region is acting as a general susceptibility locus for @DISEASE$, and is consistent with a major role for the IL-2-receptor pathway in the development and function of T cells in the control of autoimmunity. | [
"0"
] |
4068 | 4068 | @GENE$ gene microsatellite polymorphism is strongly associated with Graveso @DISEASE$ in Zhuang nationality population of Guangxi province. | [
"0"
] |
4069 | 4069 | This finding suggests that @GENE$ is a potential @DISEASE$ susceptibility gene and implies that dysregulation of neurogenesis may be involved in suicide. | [
"1"
] |
4070 | 4070 | Of the three genes encoding co-stimulatory molecules, the @GENE$ gene appears to confer risks for the development of @DISEASE$. | [
"1"
] |
4071 | 4071 | These data indicate that genetic variants in @GENE$ have pharmacogenetic effects influencing asthmatic response to corticosteroids, provide a rationale for predicting therapeutic response in @DISEASE$ and other corticosteroid-treated diseases, and suggests this gene pathway as a potential novel therapeutic target. | [
"1"
] |
4072 | 4072 | Polymorphisms of @GENE$ are associated with a higher risk of developing cervical cancer, in particular early onset cervical @DISEASE$. | [
"0"
] |
4073 | 4073 | We conclude that @GENE$ Arg38Gln polymorphism is not likely to play a major role in the @DISEASE$ of schizophrenia in Chinese populations. | [
"0"
] |
4074 | 4074 | Thus, the common -675 4G/5G polymorphism in the @GENE$ gene is strongly linked to @DISEASE$ and a markedly increased risk for obesity is associated with the 4G allele in its homozygous form. | [
"1"
] |
4075 | 4075 | The @GENE$ 1100delC allele was not over-represented in cases suggesting that this variant is not associated with an increased risk of colorectal @DISEASE$. | [
"0"
] |
4076 | 4076 | Our results suggest that the @GENE$ Ser128Arg polymorphism can functionally alter leukocyte-endothelial interactions as well as biochemical and biological consequences, which may account for the @DISEASE$ of myocardial infarction. | [
"0"
] |
4077 | 4077 | These results fail to support the theory that functional polymorphisms within the @GENE$, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for @DISEASE$. | [
"0"
] |
4078 | 4078 | Since none of the remaining DRB1*04 subtypes was associated with @GENE$ 1 DM, our study may present another piece of evidence that the DRB1*0401 and DRB1*0404 alleles do not modify @DISEASE$ risk generally in European populations. | [
"0"
] |
4079 | 4079 | The de novo origin of an RP1 (Arg677ter) mutation in a patient with simplex @DISEASE$ suggests that this common autosomal dominant RP mutation can arise independently in the population and supports the hypothesis of a mutational hotspot in the @GENE$ gene. | [
"1"
] |
4080 | 4080 | We conclude that this study has failed to produce evidence in support of the notion that variations within these 24 candidate @GENE$ and asthma genes significantly influence the expression of the atopic asthmatic phenotype or contribute to the susceptibility of @DISEASE$. | [
"1"
] |
4081 | 4081 | The mutations (Glu347Stop and Arg366Stop) of the @GENE$ gene are involved in the pathogenesis of bilateral @DISEASE$ in Japanese patients. | [
"1"
] |
4082 | 4082 | These findings provide first evidence in humans that the @GENE$ gene interacts with exposure to stressful life events to predict @DISEASE$ in adolescents. | [
"0"
] |
4083 | 4083 | Polymorphism of IL-10 -819C/T SNP site is associated with susceptibility to @DISEASE$ in Chinese Han people; at least five haplotypes of @GENE$ gene promoter (ATA, ACC, GCC, ATC and ACA) exist in Chinese Han people. | [
"1"
] |
4084 | 4084 | The results of the present study, which is much larger than previously published studies, provide no evidence that either @GENE$-Delta32 or CCR2-64I is associated with @DISEASE$. | [
"1"
] |
4085 | 4085 | The @GENE$ -251A allele may be associated with @DISEASE$ of gastric atrophy in patients with H pylori infection, and may increase the risk of gastric cancer and gastric ulcer in Japanese people. | [
"0"
] |
4086 | 4086 | Although some molecular variants within the @GENE$ gene were associated with clinical traits in @DISEASE$ patients, the low detection rate of mutations in this gene strongly suggests that variation of the SLC3A1 is not the major genetic factor contributing to cystinuria in this Mediterranean population. | [
"1"
] |
4087 | 4087 | These results suggest that the @GENE$ gene may play a role in the negative @DISEASE$ in male patients with schizophrenia. | [
"0"
] |
4088 | 4088 | The rare allele of the @GENE$ gene emerges as a candidate for a predisposing factor for the formation of sporadic @DISEASE$. | [
"1"
] |
4089 | 4089 | These new findings suggest that observed associations between NRG1 and @DISEASE$ may be mediated through functional interaction not just with @GENE$, but with other members of the NRG and ERBB families. | [
"1"
] |
4090 | 4090 | This @GENE$ coding region variant may be involved in the @DISEASE$ of AD and high total serum IgE level in a study population of white subjects. | [
"0"
] |
4091 | 4091 | The allele encoding for low activity COMT, but not @GENE$, may be a genetic risk factor for @DISEASE$ among Chinese women. | [
"1"
] |
4092 | 4092 | Our results suggest that the @GENE$ to Pro7 polymorphism of the preproNPY gene is not associated with angiographic @DISEASE$ or adverse clinical events after stent placement in coronary arteries. | [
"0"
] |
4093 | 4093 | These findings suggest that the interaction between the HLA-DRB4 and @GENE$ genes determines the thyroid function of TPO-positive goitrous Japanese @DISEASE$ patients. | [
"1"
] |
4094 | 4094 | In this large prospective study, the @GENE$ C(-260)T gene polymorphism was not associated with risks of future @DISEASE$. | [
"1"
] |
4095 | 4095 | @GENE$ G38A polymorphism had no association with the development of IgA nephropathy, but the homogeneous 38AA genotype maybe one of the genetic markers for disease progression in Chinese @DISEASE$. | [
"1"
] |
4096 | 4096 | The results from this study indicate that the TAAAA repeat polymorphism near the promoter region of the @GENE$ gene may be an important susceptibility factor for @DISEASE$ risk. | [
"1"
] |
4097 | 4097 | This study identified no statistically significant evidence for a link between @GENE$ mutations and steroid-induced @DISEASE$. | [
"1"
] |
4098 | 4098 | Our findings suggest that the genetic variations in the @GENE$ gene are significantly associated with @DISEASE$, and may play an important role in the development of essential hypertension in this Chinese population. | [
"0"
] |
4099 | 4099 | Thus, contrary to Caucasians, the GG (rather than @GENE$) genotype is associated with increased susceptibility and advanced @DISEASE$ in Singapore patients, suggesting a more complex relationship between the SNP and CRC risk, possibly modulated by population differences. | [
"0"
] |