bigbio/gad · Datasets at Hugging Face

id stringlengths 1 4	document_id stringlengths 1 4	text stringlengths 42 538	labels list
4000	4000	Since none of the remaining @GENE$04 subtypes was associated with type 1 DM, our study may present another piece of evidence that the DRB10401 and DRB1*0404 alleles do not modify @DISEASE$ risk generally in European populations.	[ "1" ]
4001	4001	Early age at onset may be a good predictor of @GENE$ @DISEASE$ in Liguria, where the G101W founder mutation is prevalent among melanoma patients, independent of family history.	[ "0" ]
4002	4002	@GENE$ and NPHP6 are major genes of @DISEASE$ associated with JS.	[ "0" ]
4003	4003	there is only a @DISEASE$ association of one SNP in @GENE$ with schizophrenia, which is not significant after multiple testing.	[ "0" ]
4004	4004	Our results suggest that @GENE$ is unlikely to play a major role in the genetic predisposition to @DISEASE$ in the German or the Palestinian-Arab population.	[ "1" ]
4005	4005	The results showed that frequencies of the genotype 86/86 and of the allele 86 were significantly decreased in MM and @DISEASE$ compared with matched healthy controls, indicating that the @GENE$ microsatellite polymorphism might represent a susceptibility locus for MM and MGUS.	[ "0" ]
4006	4006	Our preliminary results raise the concern that the CC genotype of the @GENE$ promoter at -2578 position might be associated with increased risk of renal progression in patients with @DISEASE$.	[ "1" ]
4007	4007	In addition to the @GENE$ (ACE) and angiotensinogen (AGT) gene variants, gene-gene interactions may be important causative factors in a complex @DISEASE$ such as young-onset essential hypertension.	[ "0" ]
4008	4008	Although rs7566605 was not significantly associated with @DISEASE$ in our study population, we can not rule out the involvement of INSIG2 in obesity related traits as we found significant association of another tagSNP in @GENE$ with both BMI and ABDCIR.	[ "1" ]
4009	4009	Common polymorphisms within EPHX1 and @GENE$ do not appear to be important risk factors for @DISEASE$.	[ "1" ]
4010	4010	(1) DRB1 * 0405 and DRB1 * 15 are closely associated with the susceptibility to VKH syndrome, DRB1 * 0405 may be the major susceptible gene and DRB1 * 15 may be the minor; (2) DRB1 * 14 and @GENE$ * 08 are negatively associated with the susceptibility to @DISEASE$, suggesting that they may be the resistant genes; (3) DRB1 * 0405 is not related to the clinical features, incidence of ocular complications as well as visual prognosis.	[ "1" ]
4011	4011	These studies suggest functional differences of @GENE$ haplotypes in human energy metabolism and support a role of PPARGC1 in @DISEASE$.	[ "1" ]
4012	4012	@GENE$ genes may not play a role in the carcinogenesis of @DISEASE$.	[ "1" ]
4013	4013	The R121W @DISEASE$ in @GENE$ is a predisposing factor for the development of type 2 diabetes in Okinawans.	[ "0" ]
4014	4014	For patients with heart failure caused by systolic function, the Asp298 variant of @GENE$ is associated with poorer event-free survival, particularly in patients with nonischemic @DISEASE$.	[ "0" ]
4015	4015	These results suggest no major modifying role for the Mn-@GENE$ gene polymorphism in patients with @DISEASE$.	[ "0" ]
4016	4016	Despite the strikingly similar pathologies of @GENE$ syndrome and @DISEASE$, no mutations were found to be associated with sarcoidosis in a group of patients, regardless of the presence of uveitis.	[ "1" ]
4017	4017	Our findings argue against an important predisposing effect of the @GENE$ and CDKN2A genes for @DISEASE$.	[ "1" ]
4018	4018	In conclusion, our results do not support the prevailing notion that sequence variation in the @GENE$ gene is a frequent cause of human @DISEASE$.	[ "1" ]
4019	4019	This @DISEASE$ suggests that polymorphisms in @GENE$ confer general risk to develop autoimmunity and identifies a potential therapeutic target in the prevention of autoimmune endocrine disorders.	[ "0" ]
4020	4020	Some cases of @DISEASE$ and @GENE$ could share a functionally significant polymorphism in the Sp1 transcription factor binding site in the first intron of the COL1A1 gene.	[ "0" ]
4021	4021	Our results show that the C1773 mutant of @GENE$ increases susceptibility to @DISEASE$, but not via hypercholesterolaemia.	[ "1" ]
4022	4022	Polymorphism of @GENE$ is not an inherited risk factor and is not associated with Chinese arterial thrombotic @DISEASE$, such as AMI and AIS.	[ "0" ]
4023	4023	The @GENE$ gene is less likely to play a substantial role in the development of atopy and @DISEASE$ in the Japanese population.	[ "1" ]
4024	4024	@GENE$ genotypes and haplotypes impact HIV-1 @DISEASE$ independently of CD4+ lymphocyte count and plasma HIV-1 RNA load, suggesting that the fundamental role of CX3CR1 in the alteration of disease progression might be the recruitment of immunomodulatory cells responsible for the control of HIV-1.	[ "0" ]
4025	4025	Our data suggest that potassium should be monitored with particular caution when spironolactone is started in patients with @DISEASE$ who have evidence of elevated aldosterone levels, such as high diuretic requirements, or the @GENE$ 215G allele.	[ "0" ]
4026	4026	In conclusion, carriage of the @GENE$*3 allele, as well as variant-211 UGT1A1 allele represents a risk factor for the development of, and a determinant for, metastases associated with @DISEASE$ patients.	[ "1" ]
4027	4027	The results do not support a major role for @GENE$ D repeat polymorphism in the susceptibility to @DISEASE$.	[ "1" ]
4028	4028	Our findings suggest that, among Japanese, the -28G allele of the @GENE$ promoter region confers susceptibility to @DISEASE$.	[ "0" ]
4029	4029	The PD-1 gene is significantly associated with RA susceptibility, suggesting the possibility that @GENE$ may contribute to the pathogenesis of @DISEASE$.	[ "1" ]
4030	4030	These results suggested that among IFNG and related genes, IFNG and @GENE$ genes confer genetic susceptibility to @DISEASE$ in Japanese children.	[ "0" ]
4031	4031	The 2G or 1G SNP in the @GENE$ promoter might not modify the risk of ESCC and @DISEASE$ development and might not be used as a stratification marker to predict the potential of lymphatic metastasis in these two tumor types.	[ "0" ]
4032	4032	These results show that the reduced renal excretion of uric acid in patients with @DISEASE$ is mediated by high levels of VLDL and by the high prevalence of the @GENE$ allele of apolipoprotein E.	[ "0" ]
4033	4033	Our findings suggest that the @GENE$ gene cluster polymorphisms may play a significant role in the pathogenesis of @DISEASE$ of the hip.	[ "1" ]
4034	4034	Our findings demonstrate that carriage of the low-activity S allele is associated with extremely @DISEASE$ criminal behavior in Chinese males, and suggests that the @GENE$ may be implicated in the mechanisms underlying violent behaviors.	[ "0" ]
4035	4035	The results from this study suggest that homozygosity for the @GENE$ His213 allele may be a risk factor for @DISEASE$, and its effect may be modified by the exposure level of endogenous estrogens and heterocyclic amines.	[ "1" ]
4036	4036	Our results suggest that the @GENE$ gene may play a @DISEASE$ role in the overall genetic predisposition to type 1 diabetes in this UK population.	[ "0" ]
4037	4037	Our data do not support an association of common variants in @GENE$ with @DISEASE$ in populations of European descent.	[ "1" ]
4038	4038	@GENE$ 49 AA is protective from @DISEASE$, whereas, CTLA-4 49 G allele (both as homozygotes and as heterozygotes ) confers an increased risk of diabetes mellitus.	[ "1" ]
4039	4039	In conclusion, our data suggest that @GENE$ polymorphism is a genetic modifier of the progression of @DISEASE$, possibly through inducing a partial defect in PD-1-mediated inhibition of T-cell activation.	[ "1" ]
4040	4040	Together, our findings suggest that the presence of @GENE$ gene polymorphisms may be inconclusive in the susceptibility to MS or in the clinical characteristics of Japanese patients with @DISEASE$ and, therefore, need further studies.	[ "1" ]
4041	4041	The observed genotype data in subjects from eastern Finland suggest that the Glu298Asp polymorphism of the @GENE$ gene does not contribute to @DISEASE$ in this population.	[ "1" ]
4042	4042	The @GENE$ promoter polymorphism, rs11200638, is a strong candidate with a functional consequence that predisposes Japanese to develop neovascular @DISEASE$.	[ "0" ]
4043	4043	Plasma @GENE$ is associated with @DISEASE$ by participating in the development of IR.	[ "0" ]
4044	4044	Coupled with previous findings, our data suggest that heritable @GENE$ and IL10 variations may contribute to the acquisition or progression of @DISEASE$ and that the effects of other targeted loci in the cytokine and chemokine system cannot be established unequivocally in the study populations.	[ "1" ]
4045	4045	These results imply that @GENE$(GT) genotype is associated with the @DISEASE$ of type 2 DN in Korean patients.	[ "0" ]
4046	4046	The lack of association between @GENE$ genotypes and IgE as well as @DISEASE$ outcomes in this large German study population seems to indicate that CD14 genotypes may not directly be involved in the development of allergies during childhood.	[ "1" ]
4047	4047	@GENE$ His allele is positively associated with the risk of @DISEASE$, and an interaction exist between this allele and related exposure factors.	[ "1" ]
4048	4048	The @GENE$ PlA1/A2 polymorphism is not associated with @DISEASE$, glucose metabolism, angiographic CHD or myocardial infarction.	[ "0" ]
4049	4049	Mutations in the @GENE$ gene are not a common cause of @DISEASE$.	[ "1" ]
4050	4050	Thus, variation in the @GENE$ gene may affect risk of @DISEASE$ in Japanese, especially in older individuals.	[ "1" ]
4051	4051	Our study implies that the G/C polymorphism of the @GENE$ gene may not be directly involved in the development and=or progression of @DISEASE$.	[ "1" ]
4052	4052	It is also concluded that CHEK2 protein abrogation is not caused by the @GENE$ germline variants R117G, R137Q, R145W, I157T, and R180H in familial @DISEASE$.	[ "1" ]
4053	4053	The results show that @GENE$ I249 is an independent genetic risk factor for @DISEASE$ and that CX3CR1 may be involved in the pathogenesis of atherosclerotic disease.	[ "1" ]
4054	4054	These results suggest that the @GENE$ - 3'A and CCR2b-V64I mutations do not affect the course of HCV and @DISEASE$/HCV infection in the same manner as does the CCR5-Delta32 mutation.	[ "0" ]
4055	4055	These findings show no evidence for association between @GENE$ intron 6 BamHI polymorphism and @DISEASE$ in our population.	[ "1" ]
4056	4056	common African @GENE$ and -DQB1 variants, previously associated with protection from @DISEASE$ and hepatitis B/C virus persistence, predispose the Venda to TB, whereas the proposedly active VDR haplotype F-b-A-T showed significant protection.	[ "0" ]
4057	4057	It is possible that the association seen in other studies may be due to population stratification or to the @GENE$ polymorphism being in linkage with the real @DISEASE$-causing variant(s).	[ "0" ]
4058	4058	our LD analysis did not reveal any association between @DISEASE$ in our Han Chinese population and the @GENE$ gene or its partially duplicated region.	[ "1" ]
4059	4059	We conclude that long apoB 3' VNTR alleles occur more frequently in @DISEASE$ patients, but that @GENE$ 3'VNTR genotypic variation has little impact on the risk of dyslipidemia in Taiwanese.	[ "1" ]
4060	4060	Our findings are consistent with a prior report that the Arg/His polymorphism in @GENE$ is associated with @DISEASE$ risk.	[ "1" ]
4061	4061	We conclude that carriers of N291S or combined D9N/ - 93T --> G mutations in the @GENE$ gene are at substantially increased risk of @DISEASE$.	[ "1" ]
4062	4062	Therefore, in this present study, we find no evidence for the involvement of these @GENE$ polymorphisms in increasing susceptibility to @DISEASE$.	[ "1" ]
4063	4063	suggest the existence of genetic susceptibility for @DISEASE$ in carriers of this @GENE$ functional polymorphism.	[ "1" ]
4064	4064	Deteriorating gallbladder contractions, possibly induced by alterations in the CCK-AR gene, as well as @GENE$ gene polymorphism, promoted @DISEASE$ formation.	[ "1" ]
4065	4065	These data do not support a substantial association between common genetic variation in @GENE$ and @DISEASE$ risk.	[ "1" ]
4066	4066	We conclude that heavy proteinuria itself may accelerate the @DISEASE$ of @GENE$ by increasing the MCP-1 expression in renal tubuli.	[ "0" ]
4067	4067	S Association with @GENE$, as well as that previously reported with T1D, suggests that the CD25 region is acting as a general susceptibility locus for @DISEASE$, and is consistent with a major role for the IL-2-receptor pathway in the development and function of T cells in the control of autoimmunity.	[ "0" ]
4068	4068	@GENE$ gene microsatellite polymorphism is strongly associated with Graveso @DISEASE$ in Zhuang nationality population of Guangxi province.	[ "0" ]
4069	4069	This finding suggests that @GENE$ is a potential @DISEASE$ susceptibility gene and implies that dysregulation of neurogenesis may be involved in suicide.	[ "1" ]
4070	4070	Of the three genes encoding co-stimulatory molecules, the @GENE$ gene appears to confer risks for the development of @DISEASE$.	[ "1" ]
4071	4071	These data indicate that genetic variants in @GENE$ have pharmacogenetic effects influencing asthmatic response to corticosteroids, provide a rationale for predicting therapeutic response in @DISEASE$ and other corticosteroid-treated diseases, and suggests this gene pathway as a potential novel therapeutic target.	[ "1" ]
4072	4072	Polymorphisms of @GENE$ are associated with a higher risk of developing cervical cancer, in particular early onset cervical @DISEASE$.	[ "0" ]
4073	4073	We conclude that @GENE$ Arg38Gln polymorphism is not likely to play a major role in the @DISEASE$ of schizophrenia in Chinese populations.	[ "0" ]
4074	4074	Thus, the common -675 4G/5G polymorphism in the @GENE$ gene is strongly linked to @DISEASE$ and a markedly increased risk for obesity is associated with the 4G allele in its homozygous form.	[ "1" ]
4075	4075	The @GENE$ 1100delC allele was not over-represented in cases suggesting that this variant is not associated with an increased risk of colorectal @DISEASE$.	[ "0" ]
4076	4076	Our results suggest that the @GENE$ Ser128Arg polymorphism can functionally alter leukocyte-endothelial interactions as well as biochemical and biological consequences, which may account for the @DISEASE$ of myocardial infarction.	[ "0" ]
4077	4077	These results fail to support the theory that functional polymorphisms within the @GENE$, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for @DISEASE$.	[ "0" ]
4078	4078	Since none of the remaining DRB104 subtypes was associated with @GENE$ 1 DM, our study may present another piece of evidence that the DRB10401 and DRB1*0404 alleles do not modify @DISEASE$ risk generally in European populations.	[ "0" ]
4079	4079	The de novo origin of an RP1 (Arg677ter) mutation in a patient with simplex @DISEASE$ suggests that this common autosomal dominant RP mutation can arise independently in the population and supports the hypothesis of a mutational hotspot in the @GENE$ gene.	[ "1" ]
4080	4080	We conclude that this study has failed to produce evidence in support of the notion that variations within these 24 candidate @GENE$ and asthma genes significantly influence the expression of the atopic asthmatic phenotype or contribute to the susceptibility of @DISEASE$.	[ "1" ]
4081	4081	The mutations (Glu347Stop and Arg366Stop) of the @GENE$ gene are involved in the pathogenesis of bilateral @DISEASE$ in Japanese patients.	[ "1" ]
4082	4082	These findings provide first evidence in humans that the @GENE$ gene interacts with exposure to stressful life events to predict @DISEASE$ in adolescents.	[ "0" ]
4083	4083	Polymorphism of IL-10 -819C/T SNP site is associated with susceptibility to @DISEASE$ in Chinese Han people; at least five haplotypes of @GENE$ gene promoter (ATA, ACC, GCC, ATC and ACA) exist in Chinese Han people.	[ "1" ]
4084	4084	The results of the present study, which is much larger than previously published studies, provide no evidence that either @GENE$-Delta32 or CCR2-64I is associated with @DISEASE$.	[ "1" ]
4085	4085	The @GENE$ -251A allele may be associated with @DISEASE$ of gastric atrophy in patients with H pylori infection, and may increase the risk of gastric cancer and gastric ulcer in Japanese people.	[ "0" ]
4086	4086	Although some molecular variants within the @GENE$ gene were associated with clinical traits in @DISEASE$ patients, the low detection rate of mutations in this gene strongly suggests that variation of the SLC3A1 is not the major genetic factor contributing to cystinuria in this Mediterranean population.	[ "1" ]
4087	4087	These results suggest that the @GENE$ gene may play a role in the negative @DISEASE$ in male patients with schizophrenia.	[ "0" ]
4088	4088	The rare allele of the @GENE$ gene emerges as a candidate for a predisposing factor for the formation of sporadic @DISEASE$.	[ "1" ]
4089	4089	These new findings suggest that observed associations between NRG1 and @DISEASE$ may be mediated through functional interaction not just with @GENE$, but with other members of the NRG and ERBB families.	[ "1" ]
4090	4090	This @GENE$ coding region variant may be involved in the @DISEASE$ of AD and high total serum IgE level in a study population of white subjects.	[ "0" ]
4091	4091	The allele encoding for low activity COMT, but not @GENE$, may be a genetic risk factor for @DISEASE$ among Chinese women.	[ "1" ]
4092	4092	Our results suggest that the @GENE$ to Pro7 polymorphism of the preproNPY gene is not associated with angiographic @DISEASE$ or adverse clinical events after stent placement in coronary arteries.	[ "0" ]
4093	4093	These findings suggest that the interaction between the HLA-DRB4 and @GENE$ genes determines the thyroid function of TPO-positive goitrous Japanese @DISEASE$ patients.	[ "1" ]
4094	4094	In this large prospective study, the @GENE$ C(-260)T gene polymorphism was not associated with risks of future @DISEASE$.	[ "1" ]
4095	4095	@GENE$ G38A polymorphism had no association with the development of IgA nephropathy, but the homogeneous 38AA genotype maybe one of the genetic markers for disease progression in Chinese @DISEASE$.	[ "1" ]
4096	4096	The results from this study indicate that the TAAAA repeat polymorphism near the promoter region of the @GENE$ gene may be an important susceptibility factor for @DISEASE$ risk.	[ "1" ]
4097	4097	This study identified no statistically significant evidence for a link between @GENE$ mutations and steroid-induced @DISEASE$.	[ "1" ]
4098	4098	Our findings suggest that the genetic variations in the @GENE$ gene are significantly associated with @DISEASE$, and may play an important role in the development of essential hypertension in this Chinese population.	[ "0" ]
4099	4099	Thus, contrary to Caucasians, the GG (rather than @GENE$) genotype is associated with increased susceptibility and advanced @DISEASE$ in Singapore patients, suggesting a more complex relationship between the SNP and CRC risk, possibly modulated by population differences.	[ "0" ]

4000

Since none of the remaining @GENE$*04 subtypes was associated with type 1 DM, our study may present another piece of evidence that the DRB1*0401 and DRB1*0404 alleles do not modify @DISEASE$ risk generally in European populations.

[ "1" ]

4001

Early age at onset may be a good predictor of @GENE$ @DISEASE$ in Liguria, where the G101W founder mutation is prevalent among melanoma patients, independent of family history.

[ "0" ]

4002

@GENE$ and NPHP6 are major genes of @DISEASE$ associated with JS.

[ "0" ]

4003

there is only a @DISEASE$ association of one SNP in @GENE$ with schizophrenia, which is not significant after multiple testing.

[ "0" ]

4004

Our results suggest that @GENE$ is unlikely to play a major role in the genetic predisposition to @DISEASE$ in the German or the Palestinian-Arab population.

[ "1" ]

4005

The results showed that frequencies of the genotype 86/86 and of the allele 86 were significantly decreased in MM and @DISEASE$ compared with matched healthy controls, indicating that the @GENE$ microsatellite polymorphism might represent a susceptibility locus for MM and MGUS.

[ "0" ]

4006

Our preliminary results raise the concern that the CC genotype of the @GENE$ promoter at -2578 position might be associated with increased risk of renal progression in patients with @DISEASE$.

[ "1" ]

4007

In addition to the @GENE$ (ACE) and angiotensinogen (AGT) gene variants, gene-gene interactions may be important causative factors in a complex @DISEASE$ such as young-onset essential hypertension.

[ "0" ]

4008

Although rs7566605 was not significantly associated with @DISEASE$ in our study population, we can not rule out the involvement of INSIG2 in obesity related traits as we found significant association of another tagSNP in @GENE$ with both BMI and ABDCIR.

[ "1" ]

4009

Common polymorphisms within EPHX1 and @GENE$ do not appear to be important risk factors for @DISEASE$.

[ "1" ]

4010

(1) DRB1 * 0405 and DRB1 * 15 are closely associated with the susceptibility to VKH syndrome, DRB1 * 0405 may be the major susceptible gene and DRB1 * 15 may be the minor; (2) DRB1 * 14 and @GENE$ * 08 are negatively associated with the susceptibility to @DISEASE$, suggesting that they may be the resistant genes; (3) DRB1 * 0405 is not related to the clinical features, incidence of ocular complications as well as visual prognosis.

[ "1" ]

4011

These studies suggest functional differences of @GENE$ haplotypes in human energy metabolism and support a role of PPARGC1 in @DISEASE$.

[ "1" ]

4012

@GENE$ genes may not play a role in the carcinogenesis of @DISEASE$.

[ "1" ]

4013

The R121W @DISEASE$ in @GENE$ is a predisposing factor for the development of type 2 diabetes in Okinawans.

[ "0" ]

4014

For patients with heart failure caused by systolic function, the Asp298 variant of @GENE$ is associated with poorer event-free survival, particularly in patients with nonischemic @DISEASE$.

[ "0" ]

4015

These results suggest no major modifying role for the Mn-@GENE$ gene polymorphism in patients with @DISEASE$.

[ "0" ]

4016

Despite the strikingly similar pathologies of @GENE$ syndrome and @DISEASE$, no mutations were found to be associated with sarcoidosis in a group of patients, regardless of the presence of uveitis.

[ "1" ]

4017

Our findings argue against an important predisposing effect of the @GENE$ and CDKN2A genes for @DISEASE$.

[ "1" ]

4018

In conclusion, our results do not support the prevailing notion that sequence variation in the @GENE$ gene is a frequent cause of human @DISEASE$.

[ "1" ]

4019

This @DISEASE$ suggests that polymorphisms in @GENE$ confer general risk to develop autoimmunity and identifies a potential therapeutic target in the prevention of autoimmune endocrine disorders.

[ "0" ]

4020

Some cases of @DISEASE$ and @GENE$ could share a functionally significant polymorphism in the Sp1 transcription factor binding site in the first intron of the COL1A1 gene.

[ "0" ]

4021

Our results show that the C1773 mutant of @GENE$ increases susceptibility to @DISEASE$, but not via hypercholesterolaemia.

[ "1" ]

4022

Polymorphism of @GENE$ is not an inherited risk factor and is not associated with Chinese arterial thrombotic @DISEASE$, such as AMI and AIS.

[ "0" ]

4023

The @GENE$ gene is less likely to play a substantial role in the development of atopy and @DISEASE$ in the Japanese population.

[ "1" ]

4024

@GENE$ genotypes and haplotypes impact HIV-1 @DISEASE$ independently of CD4+ lymphocyte count and plasma HIV-1 RNA load, suggesting that the fundamental role of CX3CR1 in the alteration of disease progression might be the recruitment of immunomodulatory cells responsible for the control of HIV-1.

[ "0" ]

4025

Our data suggest that potassium should be monitored with particular caution when spironolactone is started in patients with @DISEASE$ who have evidence of elevated aldosterone levels, such as high diuretic requirements, or the @GENE$ 215G allele.

[ "0" ]

4026

In conclusion, carriage of the @GENE$*3 allele, as well as variant-211 UGT1A1 allele represents a risk factor for the development of, and a determinant for, metastases associated with @DISEASE$ patients.

[ "1" ]

4027

The results do not support a major role for @GENE$ D repeat polymorphism in the susceptibility to @DISEASE$.

[ "1" ]

4028

Our findings suggest that, among Japanese, the -28G allele of the @GENE$ promoter region confers susceptibility to @DISEASE$.

[ "0" ]

4029

The PD-1 gene is significantly associated with RA susceptibility, suggesting the possibility that @GENE$ may contribute to the pathogenesis of @DISEASE$.

[ "1" ]

4030

These results suggested that among IFNG and related genes, IFNG and @GENE$ genes confer genetic susceptibility to @DISEASE$ in Japanese children.

[ "0" ]

4031

The 2G or 1G SNP in the @GENE$ promoter might not modify the risk of ESCC and @DISEASE$ development and might not be used as a stratification marker to predict the potential of lymphatic metastasis in these two tumor types.

[ "0" ]

4032

These results show that the reduced renal excretion of uric acid in patients with @DISEASE$ is mediated by high levels of VLDL and by the high prevalence of the @GENE$ allele of apolipoprotein E.

[ "0" ]

4033

Our findings suggest that the @GENE$ gene cluster polymorphisms may play a significant role in the pathogenesis of @DISEASE$ of the hip.

[ "1" ]

4034

Our findings demonstrate that carriage of the low-activity S allele is associated with extremely @DISEASE$ criminal behavior in Chinese males, and suggests that the @GENE$ may be implicated in the mechanisms underlying violent behaviors.

[ "0" ]

4035

The results from this study suggest that homozygosity for the @GENE$ His213 allele may be a risk factor for @DISEASE$, and its effect may be modified by the exposure level of endogenous estrogens and heterocyclic amines.

[ "1" ]

4036

Our results suggest that the @GENE$ gene may play a @DISEASE$ role in the overall genetic predisposition to type 1 diabetes in this UK population.

[ "0" ]

4037

Our data do not support an association of common variants in @GENE$ with @DISEASE$ in populations of European descent.

[ "1" ]

4038

@GENE$ 49 AA is protective from @DISEASE$, whereas, CTLA-4 49 G allele (both as homozygotes and as heterozygotes ) confers an increased risk of diabetes mellitus.

[ "1" ]

4039

In conclusion, our data suggest that @GENE$ polymorphism is a genetic modifier of the progression of @DISEASE$, possibly through inducing a partial defect in PD-1-mediated inhibition of T-cell activation.

[ "1" ]

4040

Together, our findings suggest that the presence of @GENE$ gene polymorphisms may be inconclusive in the susceptibility to MS or in the clinical characteristics of Japanese patients with @DISEASE$ and, therefore, need further studies.

[ "1" ]

4041

The observed genotype data in subjects from eastern Finland suggest that the Glu298Asp polymorphism of the @GENE$ gene does not contribute to @DISEASE$ in this population.

[ "1" ]

4042

The @GENE$ promoter polymorphism, rs11200638, is a strong candidate with a functional consequence that predisposes Japanese to develop neovascular @DISEASE$.

[ "0" ]

4043

Plasma @GENE$ is associated with @DISEASE$ by participating in the development of IR.

[ "0" ]

4044

Coupled with previous findings, our data suggest that heritable @GENE$ and IL10 variations may contribute to the acquisition or progression of @DISEASE$ and that the effects of other targeted loci in the cytokine and chemokine system cannot be established unequivocally in the study populations.

[ "1" ]

4045

These results imply that @GENE$(GT) genotype is associated with the @DISEASE$ of type 2 DN in Korean patients.

[ "0" ]

4046

The lack of association between @GENE$ genotypes and IgE as well as @DISEASE$ outcomes in this large German study population seems to indicate that CD14 genotypes may not directly be involved in the development of allergies during childhood.

[ "1" ]

4047

@GENE$ His allele is positively associated with the risk of @DISEASE$, and an interaction exist between this allele and related exposure factors.

[ "1" ]

4048

The @GENE$ PlA1/A2 polymorphism is not associated with @DISEASE$, glucose metabolism, angiographic CHD or myocardial infarction.

[ "0" ]

4049

Mutations in the @GENE$ gene are not a common cause of @DISEASE$.

[ "1" ]

4050

Thus, variation in the @GENE$ gene may affect risk of @DISEASE$ in Japanese, especially in older individuals.

[ "1" ]

4051

Our study implies that the G/C polymorphism of the @GENE$ gene may not be directly involved in the development and=or progression of @DISEASE$.

[ "1" ]

4052

It is also concluded that CHEK2 protein abrogation is not caused by the @GENE$ germline variants R117G, R137Q, R145W, I157T, and R180H in familial @DISEASE$.

[ "1" ]

4053

The results show that @GENE$ I249 is an independent genetic risk factor for @DISEASE$ and that CX3CR1 may be involved in the pathogenesis of atherosclerotic disease.

[ "1" ]

4054

These results suggest that the @GENE$ - 3'A and CCR2b-V64I mutations do not affect the course of HCV and @DISEASE$/HCV infection in the same manner as does the CCR5-Delta32 mutation.

[ "0" ]

4055

These findings show no evidence for association between @GENE$ intron 6 BamHI polymorphism and @DISEASE$ in our population.

[ "1" ]

4056

common African @GENE$ and -DQB1 variants, previously associated with protection from @DISEASE$ and hepatitis B/C virus persistence, predispose the Venda to TB, whereas the proposedly active VDR haplotype F-b-A-T showed significant protection.

[ "0" ]

4057

It is possible that the association seen in other studies may be due to population stratification or to the @GENE$ polymorphism being in linkage with the real @DISEASE$-causing variant(s).

[ "0" ]

4058

our LD analysis did not reveal any association between @DISEASE$ in our Han Chinese population and the @GENE$ gene or its partially duplicated region.

[ "1" ]

4059

We conclude that long apoB 3' VNTR alleles occur more frequently in @DISEASE$ patients, but that @GENE$ 3'VNTR genotypic variation has little impact on the risk of dyslipidemia in Taiwanese.

[ "1" ]

4060

Our findings are consistent with a prior report that the Arg/His polymorphism in @GENE$ is associated with @DISEASE$ risk.

[ "1" ]

4061

We conclude that carriers of N291S or combined D9N/ - 93T --> G mutations in the @GENE$ gene are at substantially increased risk of @DISEASE$.

[ "1" ]

4062

Therefore, in this present study, we find no evidence for the involvement of these @GENE$ polymorphisms in increasing susceptibility to @DISEASE$.

[ "1" ]

4063

suggest the existence of genetic susceptibility for @DISEASE$ in carriers of this @GENE$ functional polymorphism.

[ "1" ]

4064

Deteriorating gallbladder contractions, possibly induced by alterations in the CCK-AR gene, as well as @GENE$ gene polymorphism, promoted @DISEASE$ formation.

[ "1" ]

4065

These data do not support a substantial association between common genetic variation in @GENE$ and @DISEASE$ risk.

[ "1" ]

4066

We conclude that heavy proteinuria itself may accelerate the @DISEASE$ of @GENE$ by increasing the MCP-1 expression in renal tubuli.

[ "0" ]

4067

S Association with @GENE$, as well as that previously reported with T1D, suggests that the CD25 region is acting as a general susceptibility locus for @DISEASE$, and is consistent with a major role for the IL-2-receptor pathway in the development and function of T cells in the control of autoimmunity.

[ "0" ]

4068

@GENE$ gene microsatellite polymorphism is strongly associated with Graveso @DISEASE$ in Zhuang nationality population of Guangxi province.

[ "0" ]

4069

This finding suggests that @GENE$ is a potential @DISEASE$ susceptibility gene and implies that dysregulation of neurogenesis may be involved in suicide.

[ "1" ]

4070

Of the three genes encoding co-stimulatory molecules, the @GENE$ gene appears to confer risks for the development of @DISEASE$.

[ "1" ]

4071

These data indicate that genetic variants in @GENE$ have pharmacogenetic effects influencing asthmatic response to corticosteroids, provide a rationale for predicting therapeutic response in @DISEASE$ and other corticosteroid-treated diseases, and suggests this gene pathway as a potential novel therapeutic target.

[ "1" ]

4072

Polymorphisms of @GENE$ are associated with a higher risk of developing cervical cancer, in particular early onset cervical @DISEASE$.

[ "0" ]

4073

We conclude that @GENE$ Arg38Gln polymorphism is not likely to play a major role in the @DISEASE$ of schizophrenia in Chinese populations.

[ "0" ]

4074

Thus, the common -675 4G/5G polymorphism in the @GENE$ gene is strongly linked to @DISEASE$ and a markedly increased risk for obesity is associated with the 4G allele in its homozygous form.

[ "1" ]

4075

The @GENE$ 1100delC allele was not over-represented in cases suggesting that this variant is not associated with an increased risk of colorectal @DISEASE$.

[ "0" ]

4076

Our results suggest that the @GENE$ Ser128Arg polymorphism can functionally alter leukocyte-endothelial interactions as well as biochemical and biological consequences, which may account for the @DISEASE$ of myocardial infarction.

[ "0" ]

4077

These results fail to support the theory that functional polymorphisms within the @GENE$, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for @DISEASE$.

[ "0" ]

4078

Since none of the remaining DRB1*04 subtypes was associated with @GENE$ 1 DM, our study may present another piece of evidence that the DRB1*0401 and DRB1*0404 alleles do not modify @DISEASE$ risk generally in European populations.

[ "0" ]

4079

The de novo origin of an RP1 (Arg677ter) mutation in a patient with simplex @DISEASE$ suggests that this common autosomal dominant RP mutation can arise independently in the population and supports the hypothesis of a mutational hotspot in the @GENE$ gene.

[ "1" ]

4080

We conclude that this study has failed to produce evidence in support of the notion that variations within these 24 candidate @GENE$ and asthma genes significantly influence the expression of the atopic asthmatic phenotype or contribute to the susceptibility of @DISEASE$.

[ "1" ]

4081

The mutations (Glu347Stop and Arg366Stop) of the @GENE$ gene are involved in the pathogenesis of bilateral @DISEASE$ in Japanese patients.

[ "1" ]

4082

These findings provide first evidence in humans that the @GENE$ gene interacts with exposure to stressful life events to predict @DISEASE$ in adolescents.

[ "0" ]

4083

Polymorphism of IL-10 -819C/T SNP site is associated with susceptibility to @DISEASE$ in Chinese Han people; at least five haplotypes of @GENE$ gene promoter (ATA, ACC, GCC, ATC and ACA) exist in Chinese Han people.

[ "1" ]

4084

The results of the present study, which is much larger than previously published studies, provide no evidence that either @GENE$-Delta32 or CCR2-64I is associated with @DISEASE$.

[ "1" ]

4085

The @GENE$ -251A allele may be associated with @DISEASE$ of gastric atrophy in patients with H pylori infection, and may increase the risk of gastric cancer and gastric ulcer in Japanese people.

[ "0" ]

4086

Although some molecular variants within the @GENE$ gene were associated with clinical traits in @DISEASE$ patients, the low detection rate of mutations in this gene strongly suggests that variation of the SLC3A1 is not the major genetic factor contributing to cystinuria in this Mediterranean population.

[ "1" ]

4087

These results suggest that the @GENE$ gene may play a role in the negative @DISEASE$ in male patients with schizophrenia.

[ "0" ]

4088

The rare allele of the @GENE$ gene emerges as a candidate for a predisposing factor for the formation of sporadic @DISEASE$.

[ "1" ]

4089

These new findings suggest that observed associations between NRG1 and @DISEASE$ may be mediated through functional interaction not just with @GENE$, but with other members of the NRG and ERBB families.

[ "1" ]

4090

This @GENE$ coding region variant may be involved in the @DISEASE$ of AD and high total serum IgE level in a study population of white subjects.

[ "0" ]

4091

The allele encoding for low activity COMT, but not @GENE$, may be a genetic risk factor for @DISEASE$ among Chinese women.

[ "1" ]

4092

Our results suggest that the @GENE$ to Pro7 polymorphism of the preproNPY gene is not associated with angiographic @DISEASE$ or adverse clinical events after stent placement in coronary arteries.

[ "0" ]

4093

These findings suggest that the interaction between the HLA-DRB4 and @GENE$ genes determines the thyroid function of TPO-positive goitrous Japanese @DISEASE$ patients.

[ "1" ]

4094

In this large prospective study, the @GENE$ C(-260)T gene polymorphism was not associated with risks of future @DISEASE$.

[ "1" ]

4095

@GENE$ G38A polymorphism had no association with the development of IgA nephropathy, but the homogeneous 38AA genotype maybe one of the genetic markers for disease progression in Chinese @DISEASE$.

[ "1" ]

4096

The results from this study indicate that the TAAAA repeat polymorphism near the promoter region of the @GENE$ gene may be an important susceptibility factor for @DISEASE$ risk.

[ "1" ]

4097

This study identified no statistically significant evidence for a link between @GENE$ mutations and steroid-induced @DISEASE$.

[ "1" ]

4098

Our findings suggest that the genetic variations in the @GENE$ gene are significantly associated with @DISEASE$, and may play an important role in the development of essential hypertension in this Chinese population.

[ "0" ]

4099

Thus, contrary to Caucasians, the GG (rather than @GENE$) genotype is associated with increased susceptibility and advanced @DISEASE$ in Singapore patients, suggesting a more complex relationship between the SNP and CRC risk, possibly modulated by population differences.

[ "0" ]