bigbio/gad · Datasets at Hugging Face

id stringlengths 1 4	document_id stringlengths 1 4	text stringlengths 42 538	labels list
3800	3800	In summary, a rare P387L variant of the PTP-1B gene is associated with a 3.7 (CI 1.26-10.93, P = 0.02) genotype relative risk of @DISEASE$ in the examined population of Danish Caucasian subjects and results in impaired in vitro serine phosphorylation of the @GENE$ peptide.	[ "1" ]
3801	3801	Our data suggest that @GENE$ exon 1 structural variants are significantly associated with susceptibility to childhood @DISEASE$ in an age-dependent manner.	[ "1" ]
3802	3802	We found no evidence that MSR1 and @GENE$ germline mutations are associated with @DISEASE$ risk in Jews.	[ "1" ]
3803	3803	Our data, therefore, do not support the hypothesis that genetic variation in MAOA and @GENE$ is involved individually or in combination in the etiology of @DISEASE$.	[ "1" ]
3804	3804	These findings suggest that the T allele, encoding aspartic acid, of the Glu298Asp polymorphism of the @GENE$ may be associated with advanced stage @DISEASE$ in the Korean population.	[ "1" ]
3805	3805	we could not find evidence of association between RGS4, PRODH, @GENE$ and GRK3 genes and @DISEASE$ 1 in the Scottish population.	[ "1" ]
3806	3806	@GENE$ and HLA-G polymorphisms can independently and synergistically influence susceptibility to heterosexual acquisition of @DISEASE$-1.	[ "1" ]
3807	3807	These analyses suggest that variation in the @GENE$ gene may primarily affect the inattentive subtype of @DISEASE$.	[ "1" ]
3808	3808	The results indicate that carriage of the homozygous 211 G to A variation within the coding region in the @GENE$ gene is an additive risk factor for @DISEASE$ in G6PD-deficient Taiwanese male neonates.	[ "0" ]
3809	3809	Our study provided evidence against an association between @GENE$ M235T or chymase gene CMA/B polymorphisms and the presence of incipient or overt nephropathy in Caucasian patients with @DISEASE$.	[ "0" ]
3810	3810	Our findings suggest an @GENE$ of allelic variation in 5-@DISEASE$(1A) receptor expression on the development of interferon alfa-induced depression during antiviral treatment of chronic hepatitis C. Prediction models of interferon-induced depressive symptoms based on HTR1A variation offer a perspective for an antidepressant selective serotonin reuptake inhibitor prophylaxis in patients genetically at risk for interferon-induced depression.	[ "0" ]
3811	3811	Gln223Arg variant in @GENE$ gene is associated with @DISEASE$ in type II diabetic male patients, especially with elevation of systolic blood pressure.	[ "1" ]
3812	3812	Simultaneous @DISEASE$ in codons 12 and @GENE$ of the K-ras gene appears to be a positive prognostic indicator in colorectal cancer.	[ "0" ]
3813	3813	It seems plausible that the association between the @GENE$ VNTR and @DISEASE$ behaviour indicates that dysregulation of dopamine reuptake may act as a common pathophysiologic mechanism in eating disorders with binge-eating behaviour and in disorders related to substance use.	[ "0" ]
3814	3814	Although @GENE$ genotype was not reliably associated with ad lib drinking behavior, the results suggest that individuals with the long-long (LL) genotype may develop acute tolerance to @DISEASE$ more rapidly than heterozygotes or individuals homozygous for the short SERT allele.	[ "1" ]
3815	3815	These results suggest that the amino-terminal polymorphisms of the @GENE$-adrenergic receptor gene in codon 27 were associated with hypertryglyceridemia and independent of @DISEASE$, and thereby could be involved in the molecular pathogenesis of fatty liver.	[ "0" ]
3816	3816	Our results support the hypothesis that certain genetic variations contained within the @GENE$ gene family contribute to the @DISEASE$ of dementia.	[ "0" ]
3817	3817	A promoter @DISEASE$ in a @GENE$ regulator affecting the binding of a POU-type transcription factor may be involved in BD and SZ in a subset of patients.	[ "0" ]
3818	3818	Thus, our data suggest that an excess of high-activity @GENE$ gene promoter alleles resulting in an elevated MAO-A activity is a risk factor for @DISEASE$ in females.	[ "1" ]
3819	3819	Genetic variations in the @GENE$ and IL-1ra gene identify @DISEASE$ patients at risk for increased bone loss.	[ "0" ]
3820	3820	The results of our studies show that the @GENE$ gene is not a major contributor to susceptibility to @DISEASE$ in Ashkenazi Jews.	[ "1" ]
3821	3821	@GENE$ mutations are not a common cause of @DISEASE$ phenotypes.	[ "1" ]
3822	3822	The effect of RLX on @GENE$ in postmenopausal women with @DISEASE$ is regulated by the polymorphisms of Fok I of VDR gene and Pvu II of ESR1 gene.	[ "0" ]
3823	3823	Our study indicated that @GENE$ gene variants associated with a @DISEASE$ phenotype were more susceptible to the effects of tobacco smoking with respect to adenoma risk, providing leads for disease prevention.	[ "0" ]
3824	3824	Our results do not support the hypothesis that the V89L and A49T polymorphisms in the @GENE$ gene are related to the risk of @DISEASE$, but are compatible with the suggestion from earlier studies that men who are homozygous for the TA(9) or (18) alleles and men who have the TA(9)/TA(18) genotype are at a modestly reduced risk.	[ "1" ]
3825	3825	These data suggest that the @GENE$ genotype of the host can influence the development of @DISEASE$ among patients with gastroesophageal malignancy.	[ "0" ]
3826	3826	Our @DISEASE$ may contribute to understanding of the pathophysiology of @GENE$ as well as to a priori identification of patients vulnerable for development of AIP.	[ "0" ]
3827	3827	it is possible that common variants in the @GENE$ and CHEK2 genes, in interaction with oestrogen-related exposures, are involved in @DISEASE$ aetiology.	[ "1" ]
3828	3828	Our findings support the hypothesis that alterations in the @GENE$ signalling system could contribute to serum insulin levels and the development of @DISEASE$.	[ "0" ]
3829	3829	Lack of association of @GENE$ polymorphisms or haplotypes precludes a major role of this gene increasing predisposition to these inflammatory @DISEASE$.	[ "0" ]
3830	3830	According to our study, the frequency of the homozygote state (T/T) of @GENE$ and increased @DISEASE$ levels of homocysteine is greater in women suffering from preeclampsia.	[ "0" ]
3831	3831	a genetic variant of the 3' part of the @GENE$ gene may be a susceptibility factor for a phenotype combining suicidal behavior, @DISEASE$ and impulsive aggression.	[ "0" ]
3832	3832	This is the first paper demonstrating that functional genotype of @GENE$ promoter is a risk factor for oral @DISEASE$, particularly for the subsets occurring on non-buccal site.	[ "0" ]
3833	3833	This study shows that patients with MVP have a higher frequency of PLAU T4065C TC genotype and T allele that supports a role of the @GENE$ T4065C polymorphism in determining the risk of @DISEASE$ among the Chinese population in Taiwan.	[ "1" ]
3834	3834	In conclusion, in our population Val-Ala polymorphism in Mn-@GENE$ influences neither susceptibility to alcohol-induced @DISEASE$ nor alcohol-induced oxidative stress.	[ "0" ]
3835	3835	These results became important once the C677T @GENE$ gene polymorphism was found to be an independent risk factor for @DISEASE$, a common clinical event in sickle cell disease.	[ "0" ]
3836	3836	Our data suggest that there is no association between the C677T mutation of the human @GENE$ gene and the risk of @DISEASE$ or VT among Chinese in Taiwan.	[ "1" ]
3837	3837	We have developed a novel assay to genotype the @GENE$-158F/V polymorphism and confirmed that homozygosity for the FcgammaRIIIA-158V allele is associated with UK Caucasian @DISEASE$, particularly in those individuals with nodules, suggesting FcgammaRIIIA may play a role in determining disease severity or in the development of nodules per se.	[ "0" ]
3838	3838	These findings indicated that the polymorphism of CD14 but not TLR4 Asp299Gly mutation was associated with Chinese patients with @DISEASE$, and the @GENE$ gene may contribute to the predisposition to colorectal cancer.	[ "1" ]
3839	3839	we found no association between common genetic variation in the 17q21 @GENE$ amplicon and @DISEASE$ risk in British women.	[ "1" ]
3840	3840	The significant association of IL13 and @GENE$ promoter polymorphisms with latex allergy suggests a potential location for genetic control in the induction of @DISEASE$ in individuals and extends the understanding of the genetic basis for the induction of immediate-type hypersensitivity in healthcare workers occupationally exposed to natural rubber latex.	[ "1" ]
3841	3841	In our cohort of white Spaniards, homozygosity for the variant @GENE$-2518GG genotype is overrepresented in @DISEASE$-1-infected subjects.	[ "1" ]
3842	3842	This result provides evidence that the @GENE$ pseudodeficient N-glycosylation site allele increases the risk of @DISEASE$ within a Korean population.	[ "1" ]
3843	3843	This particular single nucleotide polymorphism of @GENE$ does not seem to be associated with @DISEASE$.	[ "1" ]
3844	3844	A common genetic variation at a locus controlling the expression of the @GENE$ locus increases the susceptibility to @DISEASE$ and is associated with poor control of the condition in children and young adults.	[ "0" ]
3845	3845	Our findings suggest that the increased production of hPR-B by the +331 G/A polymorphism may predispose women to @DISEASE$ development through increased hPR-B-dependent stimulation of mammary @GENE$ growth.	[ "0" ]
3846	3846	The Bst U I polymorphism of the @GENE$ gene is a suitable genetic marker of @DISEASE$ but cannot be used in the prediction of the outcome of patients who have received hormonal therapy.	[ "1" ]
3847	3847	These findings suggest that a @DISEASE$ in the @GENE$ gene may predispose individuals to life-threatening bacterial infections.	[ "0" ]
3848	3848	There was an association of @GENE$*0901 with MPA and MPO-ANCA positive @DISEASE$ in Japanese patients.	[ "0" ]
3849	3849	Combining the two 'candidate' SNPs (P187S and R72P) revealed an increased risk for @DISEASE$ of double heterozygotes (P187S/R72P) of the NQO1 and @GENE$ genes (OR=1.88; 95% CI 1.13-3.15; P=0.011), suggesting a possible interaction of these two loci.	[ "1" ]
3850	3850	Neither the PAI-1 4G/5G polymorphism nor the @GENE$ antigen level is a strong risk factor for @DISEASE$.	[ "1" ]
3851	3851	These findings suggest that the presence of the variant allele in the promoter of MMP2 or @GENE$ may be a protective factor for the development of @DISEASE$.	[ "1" ]
3852	3852	These results suggest that the rs1862214 polymorphism in @GENE$ is predictive for @DISEASE$ risk and prognosis, and that PDCD5 may represent a novel tumor suppressor gene influencing lung cancer.	[ "1" ]
3853	3853	Our results suggest that the C allele of the @GENE$ polymorphism is significantly associated with increased @DISEASE$ risk and clinically advanced disease in African Americans.	[ "1" ]
3854	3854	The results suggest that @GENE$ may play a role in @DISEASE$ probably through increasing insulin resistance.	[ "0" ]
3855	3855	Heterozygosis for @GENE$ mutations is a novel risk factor for both hepatic iron accumulation and the @DISEASE$ to fibrosis in patients with CHC.	[ "0" ]
3856	3856	We conclude that DNA polymorphisms located in @GENE$ might contribute to the development of @DISEASE$.	[ "0" ]
3857	3857	The @GENE$ +78A(+) genotype may have a protective effect against the development and/or @DISEASE$ of diabetic nephropathy in Japanese type 2 diabetic patients.	[ "0" ]
3858	3858	The @GENE$ polymorphism is attributable to the hereditary variation of AHSG and phosphate serum levels, which may affect skeletal development and @DISEASE$ such as vascular calcification.	[ "0" ]
3859	3859	These data suggest that the IL4-589T allele is a risk factor for life-threatening asthma and that the @GENE$576R allele is a risk factor for a low level of lung function in @DISEASE$ subjects.	[ "1" ]
3860	3860	No association between the -231 G > A polymorphism in the @GENE$ gene and preeclampsia as well as any correlation with the main clinical features of the @DISEASE$ were found, thus excluding a role for this polymorphism in susceptibility to preeclampsia.	[ "0" ]
3861	3861	These results suggest that the @GENE$ gene may play a role in the negative symptoms in male patients with @DISEASE$.	[ "1" ]
3862	3862	The study showed a positive association between panic disorder and the HTR2A gene, suggesting that @GENE$ plays an important role in the pathogenesis of @DISEASE$.	[ "1" ]
3863	3863	a genetic polymorphism links MPO expression to Alzheimer's risk, in that a higher expressing SpSp @GENE$ genotype was associated with increased incidence of @DISEASE$ in females, and decreased incidence in males (P = 0.006)	[ "1" ]
3864	3864	Thus, neither @GENE$ nor DMB was associated with @DISEASE$ in this population, and not all shared-epitope-bearing haplotypes had the same DMB allele distribution.	[ "1" ]
3865	3865	Variation in the @GENE$ gene may play a role in the @DISEASE$ of AD.	[ "0" ]
3866	3866	The novel @GENE$ Ala57Thr was common in and population specific to Greenlander Inuit, with Thr57 associated with a lower risk of @DISEASE$ in those living in Denmark.	[ "0" ]
3867	3867	The present study does not support that the investigated NOTCH4 variants have a major influence on susceptibility to @DISEASE$ or related neurobiological @GENE$.	[ "0" ]
3868	3868	The @GENE$ gene 572C/T polymorphism has no significant effect on the development and @DISEASE$ of breast cancer.	[ "0" ]
3869	3869	This data indicates that the T102C polymorphism in the @GENE$) gene might be an independent risk factor for @DISEASE$ in female individuals with essential hypertension.	[ "1" ]
3870	3870	In this study we were not able to detect differences of frequency of the allele T (-260) in the promoter of the @GENE$ receptor gene in survivors of @DISEASE$ and controls.	[ "1" ]
3871	3871	In the oldest old, the presence of the @GENE$ epsilon2 allele (APOE2) was associated with a somewhat reduced risk of @DISEASE$, but paradoxically was associated with increased Alzheimer disease (AD) neuropathology.	[ "0" ]
3872	3872	Our results suggest MMP-2 and @GENE$ genotypes play a crucial role in @DISEASE$ invasion, but not with development of gastric cancer.	[ "1" ]
3873	3873	These findings suggest that the @GENE$ gene is not primarily involved in susceptibility to @DISEASE$ in the Japanese population.	[ "1" ]
3874	3874	The results suggest that existence of a @DISEASE$ in the @GENE$ gene is associated with an increased susceptibility to developing UC, especially chronic continuous distal colitis phenotypes that develop after 20 years of age.	[ "0" ]
3875	3875	@GENE$ is a potential locus associated with @DISEASE$ in the Han Chinese population.	[ "0" ]
3876	3876	There was no evidence in this study for the association of AGT M235T and @GENE$ I/D polymorphism with @DISEASE$ in Chinese population in Chengdu area.	[ "1" ]
3877	3877	@GENE$ gene may contribute to the genetic susceptibility to @DISEASE$ in Han population.	[ "1" ]
3878	3878	In patients with CHF, the presence of @DISEASE$ was significantly associated with certain ACE and @GENE$ genotypes.	[ "1" ]
3879	3879	The significant association of @DISEASE$ with the @GENE$*3 allele encoding a low detoxification activity protein is identified and implicates UGT1A7 as a risk gene of hepatocarcinogenesis in addition to a role as potential marker for cancer risk assessment in chronic liver disease.	[ "1" ]
3880	3880	Compared to a previous smaller study of @GENE$ receptor blockade in @DISEASE$, we could not confirm that CYP11B2 -344T/C genotypes contribute towards explaining the observed variability in response to treatment with angiotensin II receptor blockers, which could be due to lack of power.	[ "0" ]
3881	3881	Our results do not show that @GENE$-173 gene polymorphism may infer a direct risk for @DISEASE$ susceptibility or CV disease in patients with RA.	[ "0" ]
3882	3882	@GENE$ gene may be not a susceptibility gene of @DISEASE$ patients of Han population in southwest China.	[ "1" ]
3883	3883	The results indicate that the increase in allelic frequency of 1166C is a risk factor and hence suggest that the change in the @GENE$ type I receptor gene is associated with @DISEASE$.	[ "0" ]
3884	3884	We have failed to confirm the association between the @GENE$ gene polymorphism and @DISEASE$ susceptibility or severity.	[ "1" ]
3885	3885	The @GENE$ 1908C/T polymorphism plays an important role in the development of cerebral @DISEASE$ and diabetic nephropathy in Japanese men with type 2 diabetes.	[ "0" ]
3886	3886	Mutational analysis of the @GENE$ gene in a series of Italian patients revealed one @DISEASE$ and confirmed an important role played by this gene in a significant proportion of patients affected by keratoconus, when it is inherited as an autosomal dominant trait with variable expressivity and incomplete penetrance.	[ "0" ]
3887	3887	These data indicate that genetic variants in @GENE$ have pharmacogenetic effects influencing @DISEASE$ response to corticosteroids, provide a rationale for predicting therapeutic response in asthma and other corticosteroid-treated diseases, and suggests this gene pathway as a potential novel therapeutic target.	[ "1" ]
3888	3888	that the 1858C/T allele is the major risk variant for type 1 diabetes in the PTPN22 locus, but they suggest that additional infrequent coding variants at @GENE$ may also contribute to @DISEASE$ risk.	[ "1" ]
3889	3889	Our results do not support a role for -94ins/delATTG @GENE$ promoter polymorphism in susceptibility and clinical expression of @DISEASE$ in a Northwestern Spanish population.	[ "1" ]
3890	3890	The Gly49 allele in the beta1-adrenergic receptor and the 5' LC-Cys19, Arg16, and Gln27 alleles in the @GENE$-adrenergic receptor were associated with a lower risk of @DISEASE$ in idiopathic dilated cardiomyopathy, suggesting that the beta1- and beta2-adrenergic receptor genes are modifier genes.	[ "0" ]
3891	3891	The @GENE$ polymorphisms studied do not contribute to disease susceptibility in Japanese or Dutch @DISEASE$ patients.	[ "1" ]
3892	3892	Given the pivotal role of LDH in the metabolism of lactate, a known inducer of @DISEASE$, and the dependence of LDH activity on @GENE$ pH, we suggest that LDHA polymorphisms may contribute to the variability to CO(2) respiratory challenge.	[ "0" ]
3893	3893	from this study may provide further evidence that @GENE$ M129V is not a genetic susceptibility factor for @DISEASE$, MCI, alcoholism and schizophrenia in a Korean population.	[ "0" ]
3894	3894	Our results suggest that homozygosity for 3435T alleles of ABCB1 is a risk factor for occurrence of nortriptyline-induced postural @DISEASE$ (@GENE$, P = 0.042, 95% CI 1.01-1.86).	[ "0" ]
3895	3895	@GENE$ polymorphisms may have a significant modifying effect on @DISEASE$ risk, which may interact with environmental factors, cigarette smoking and alcohol drinking in colorectal carcinogenesis.	[ "1" ]
3896	3896	in the investigated German sample, no evidence of association of ABCB11 and @GENE$ to @DISEASE$ susceptibility was detected.	[ "1" ]
3897	3897	The @GENE$ missense variant P1054R confers an about twofold increased risk for @DISEASE$ in our series.	[ "1" ]
3898	3898	The results suggest that the 5A/6A polymorphism of @GENE$ gene may not be linked with appearance and/or @DISEASE$ of ovarian cancer.	[ "0" ]
3899	3899	The @GENE$ C(-260)T polymorphism is associated with a history of ACS and it may represent a genetically determined risk factor for the development of ACS and @DISEASE$ vulnerability in angina patients.	[ "0" ]

3800

In summary, a rare P387L variant of the PTP-1B gene is associated with a 3.7 (CI 1.26-10.93, P = 0.02) genotype relative risk of @DISEASE$ in the examined population of Danish Caucasian subjects and results in impaired in vitro serine phosphorylation of the @GENE$ peptide.

[ "1" ]

3801

Our data suggest that @GENE$ exon 1 structural variants are significantly associated with susceptibility to childhood @DISEASE$ in an age-dependent manner.

[ "1" ]

3802

We found no evidence that MSR1 and @GENE$ germline mutations are associated with @DISEASE$ risk in Jews.

[ "1" ]

3803

Our data, therefore, do not support the hypothesis that genetic variation in MAOA and @GENE$ is involved individually or in combination in the etiology of @DISEASE$.

[ "1" ]

3804

These findings suggest that the T allele, encoding aspartic acid, of the Glu298Asp polymorphism of the @GENE$ may be associated with advanced stage @DISEASE$ in the Korean population.

[ "1" ]

3805

we could not find evidence of association between RGS4, PRODH, @GENE$ and GRK3 genes and @DISEASE$ 1 in the Scottish population.

[ "1" ]

3806

@GENE$ and HLA-G polymorphisms can independently and synergistically influence susceptibility to heterosexual acquisition of @DISEASE$-1.

[ "1" ]

3807

These analyses suggest that variation in the @GENE$ gene may primarily affect the inattentive subtype of @DISEASE$.

[ "1" ]

3808

The results indicate that carriage of the homozygous 211 G to A variation within the coding region in the @GENE$ gene is an additive risk factor for @DISEASE$ in G6PD-deficient Taiwanese male neonates.

[ "0" ]

3809

Our study provided evidence against an association between @GENE$ M235T or chymase gene CMA/B polymorphisms and the presence of incipient or overt nephropathy in Caucasian patients with @DISEASE$.

[ "0" ]

3810

Our findings suggest an @GENE$ of allelic variation in 5-@DISEASE$(1A) receptor expression on the development of interferon alfa-induced depression during antiviral treatment of chronic hepatitis C. Prediction models of interferon-induced depressive symptoms based on HTR1A variation offer a perspective for an antidepressant selective serotonin reuptake inhibitor prophylaxis in patients genetically at risk for interferon-induced depression.

[ "0" ]

3811

Gln223Arg variant in @GENE$ gene is associated with @DISEASE$ in type II diabetic male patients, especially with elevation of systolic blood pressure.

[ "1" ]

3812

Simultaneous @DISEASE$ in codons 12 and @GENE$ of the K-ras gene appears to be a positive prognostic indicator in colorectal cancer.

[ "0" ]

3813

It seems plausible that the association between the @GENE$ VNTR and @DISEASE$ behaviour indicates that dysregulation of dopamine reuptake may act as a common pathophysiologic mechanism in eating disorders with binge-eating behaviour and in disorders related to substance use.

[ "0" ]

3814

Although @GENE$ genotype was not reliably associated with ad lib drinking behavior, the results suggest that individuals with the long-long (LL) genotype may develop acute tolerance to @DISEASE$ more rapidly than heterozygotes or individuals homozygous for the short SERT allele.

[ "1" ]

3815

These results suggest that the amino-terminal polymorphisms of the @GENE$-adrenergic receptor gene in codon 27 were associated with hypertryglyceridemia and independent of @DISEASE$, and thereby could be involved in the molecular pathogenesis of fatty liver.

[ "0" ]

3816

Our results support the hypothesis that certain genetic variations contained within the @GENE$ gene family contribute to the @DISEASE$ of dementia.

[ "0" ]

3817

A promoter @DISEASE$ in a @GENE$ regulator affecting the binding of a POU-type transcription factor may be involved in BD and SZ in a subset of patients.

[ "0" ]

3818

Thus, our data suggest that an excess of high-activity @GENE$ gene promoter alleles resulting in an elevated MAO-A activity is a risk factor for @DISEASE$ in females.

[ "1" ]

3819

Genetic variations in the @GENE$ and IL-1ra gene identify @DISEASE$ patients at risk for increased bone loss.

[ "0" ]

3820

The results of our studies show that the @GENE$ gene is not a major contributor to susceptibility to @DISEASE$ in Ashkenazi Jews.

[ "1" ]

3821

@GENE$ mutations are not a common cause of @DISEASE$ phenotypes.

[ "1" ]

3822

The effect of RLX on @GENE$ in postmenopausal women with @DISEASE$ is regulated by the polymorphisms of Fok I of VDR gene and Pvu II of ESR1 gene.

[ "0" ]

3823

Our study indicated that @GENE$ gene variants associated with a @DISEASE$ phenotype were more susceptible to the effects of tobacco smoking with respect to adenoma risk, providing leads for disease prevention.

[ "0" ]

3824

Our results do not support the hypothesis that the V89L and A49T polymorphisms in the @GENE$ gene are related to the risk of @DISEASE$, but are compatible with the suggestion from earlier studies that men who are homozygous for the TA(9) or (18) alleles and men who have the TA(9)/TA(18) genotype are at a modestly reduced risk.

[ "1" ]

3825

These data suggest that the @GENE$ genotype of the host can influence the development of @DISEASE$ among patients with gastroesophageal malignancy.

[ "0" ]

3826

Our @DISEASE$ may contribute to understanding of the pathophysiology of @GENE$ as well as to a priori identification of patients vulnerable for development of AIP.

[ "0" ]

3827

it is possible that common variants in the @GENE$ and CHEK2 genes, in interaction with oestrogen-related exposures, are involved in @DISEASE$ aetiology.

[ "1" ]

3828

Our findings support the hypothesis that alterations in the @GENE$ signalling system could contribute to serum insulin levels and the development of @DISEASE$.

[ "0" ]

3829

Lack of association of @GENE$ polymorphisms or haplotypes precludes a major role of this gene increasing predisposition to these inflammatory @DISEASE$.

[ "0" ]

3830

According to our study, the frequency of the homozygote state (T/T) of @GENE$ and increased @DISEASE$ levels of homocysteine is greater in women suffering from preeclampsia.

[ "0" ]

3831

a genetic variant of the 3' part of the @GENE$ gene may be a susceptibility factor for a phenotype combining suicidal behavior, @DISEASE$ and impulsive aggression.

[ "0" ]

3832

This is the first paper demonstrating that functional genotype of @GENE$ promoter is a risk factor for oral @DISEASE$, particularly for the subsets occurring on non-buccal site.

[ "0" ]

3833

This study shows that patients with MVP have a higher frequency of PLAU T4065C TC genotype and T allele that supports a role of the @GENE$ T4065C polymorphism in determining the risk of @DISEASE$ among the Chinese population in Taiwan.

[ "1" ]

3834

In conclusion, in our population Val-Ala polymorphism in Mn-@GENE$ influences neither susceptibility to alcohol-induced @DISEASE$ nor alcohol-induced oxidative stress.

[ "0" ]

3835

These results became important once the C677T @GENE$ gene polymorphism was found to be an independent risk factor for @DISEASE$, a common clinical event in sickle cell disease.

[ "0" ]

3836

Our data suggest that there is no association between the C677T mutation of the human @GENE$ gene and the risk of @DISEASE$ or VT among Chinese in Taiwan.

[ "1" ]

3837

We have developed a novel assay to genotype the @GENE$-158F/V polymorphism and confirmed that homozygosity for the FcgammaRIIIA-158V allele is associated with UK Caucasian @DISEASE$, particularly in those individuals with nodules, suggesting FcgammaRIIIA may play a role in determining disease severity or in the development of nodules per se.

[ "0" ]

3838

These findings indicated that the polymorphism of CD14 but not TLR4 Asp299Gly mutation was associated with Chinese patients with @DISEASE$, and the @GENE$ gene may contribute to the predisposition to colorectal cancer.

[ "1" ]

3839

we found no association between common genetic variation in the 17q21 @GENE$ amplicon and @DISEASE$ risk in British women.

[ "1" ]

3840

The significant association of IL13 and @GENE$ promoter polymorphisms with latex allergy suggests a potential location for genetic control in the induction of @DISEASE$ in individuals and extends the understanding of the genetic basis for the induction of immediate-type hypersensitivity in healthcare workers occupationally exposed to natural rubber latex.

[ "1" ]

3841

In our cohort of white Spaniards, homozygosity for the variant @GENE$-2518GG genotype is overrepresented in @DISEASE$-1-infected subjects.

[ "1" ]

3842

This result provides evidence that the @GENE$ pseudodeficient N-glycosylation site allele increases the risk of @DISEASE$ within a Korean population.

[ "1" ]

3843

This particular single nucleotide polymorphism of @GENE$ does not seem to be associated with @DISEASE$.

[ "1" ]

3844

A common genetic variation at a locus controlling the expression of the @GENE$ locus increases the susceptibility to @DISEASE$ and is associated with poor control of the condition in children and young adults.

[ "0" ]

3845

Our findings suggest that the increased production of hPR-B by the +331 G/A polymorphism may predispose women to @DISEASE$ development through increased hPR-B-dependent stimulation of mammary @GENE$ growth.

[ "0" ]

3846

The Bst U I polymorphism of the @GENE$ gene is a suitable genetic marker of @DISEASE$ but cannot be used in the prediction of the outcome of patients who have received hormonal therapy.

[ "1" ]

3847

These findings suggest that a @DISEASE$ in the @GENE$ gene may predispose individuals to life-threatening bacterial infections.

[ "0" ]

3848

There was an association of @GENE$*0901 with MPA and MPO-ANCA positive @DISEASE$ in Japanese patients.

[ "0" ]

3849

Combining the two 'candidate' SNPs (P187S and R72P) revealed an increased risk for @DISEASE$ of double heterozygotes (P187S/R72P) of the NQO1 and @GENE$ genes (OR=1.88; 95% CI 1.13-3.15; P=0.011), suggesting a possible interaction of these two loci.

[ "1" ]

3850

Neither the PAI-1 4G/5G polymorphism nor the @GENE$ antigen level is a strong risk factor for @DISEASE$.

[ "1" ]

3851

These findings suggest that the presence of the variant allele in the promoter of MMP2 or @GENE$ may be a protective factor for the development of @DISEASE$.

[ "1" ]

3852

These results suggest that the rs1862214 polymorphism in @GENE$ is predictive for @DISEASE$ risk and prognosis, and that PDCD5 may represent a novel tumor suppressor gene influencing lung cancer.

[ "1" ]

3853

Our results suggest that the C allele of the @GENE$ polymorphism is significantly associated with increased @DISEASE$ risk and clinically advanced disease in African Americans.

[ "1" ]

3854

The results suggest that @GENE$ may play a role in @DISEASE$ probably through increasing insulin resistance.

[ "0" ]

3855

Heterozygosis for @GENE$ mutations is a novel risk factor for both hepatic iron accumulation and the @DISEASE$ to fibrosis in patients with CHC.

[ "0" ]

3856

We conclude that DNA polymorphisms located in @GENE$ might contribute to the development of @DISEASE$.

[ "0" ]

3857

The @GENE$ +78A(+) genotype may have a protective effect against the development and/or @DISEASE$ of diabetic nephropathy in Japanese type 2 diabetic patients.

[ "0" ]

3858

The @GENE$ polymorphism is attributable to the hereditary variation of AHSG and phosphate serum levels, which may affect skeletal development and @DISEASE$ such as vascular calcification.

[ "0" ]

3859

These data suggest that the IL4*-589T allele is a risk factor for life-threatening asthma and that the @GENE$*576R allele is a risk factor for a low level of lung function in @DISEASE$ subjects.

[ "1" ]

3860

No association between the -231 G > A polymorphism in the @GENE$ gene and preeclampsia as well as any correlation with the main clinical features of the @DISEASE$ were found, thus excluding a role for this polymorphism in susceptibility to preeclampsia.

[ "0" ]

3861

These results suggest that the @GENE$ gene may play a role in the negative symptoms in male patients with @DISEASE$.

[ "1" ]

3862

The study showed a positive association between panic disorder and the HTR2A gene, suggesting that @GENE$ plays an important role in the pathogenesis of @DISEASE$.

[ "1" ]

3863

a genetic polymorphism links MPO expression to Alzheimer's risk, in that a higher expressing SpSp @GENE$ genotype was associated with increased incidence of @DISEASE$ in females, and decreased incidence in males (P = 0.006)

[ "1" ]

3864

Thus, neither @GENE$ nor DMB was associated with @DISEASE$ in this population, and not all shared-epitope-bearing haplotypes had the same DMB allele distribution.

[ "1" ]

3865

Variation in the @GENE$ gene may play a role in the @DISEASE$ of AD.

[ "0" ]

3866

The novel @GENE$ Ala57Thr was common in and population specific to Greenlander Inuit, with Thr57 associated with a lower risk of @DISEASE$ in those living in Denmark.

[ "0" ]

3867

The present study does not support that the investigated NOTCH4 variants have a major influence on susceptibility to @DISEASE$ or related neurobiological @GENE$.

[ "0" ]

3868

The @GENE$ gene 572C/T polymorphism has no significant effect on the development and @DISEASE$ of breast cancer.

[ "0" ]

3869

This data indicates that the T102C polymorphism in the @GENE$) gene might be an independent risk factor for @DISEASE$ in female individuals with essential hypertension.

[ "1" ]

3870

In this study we were not able to detect differences of frequency of the allele T (-260) in the promoter of the @GENE$ receptor gene in survivors of @DISEASE$ and controls.

[ "1" ]

3871

In the oldest old, the presence of the @GENE$ epsilon2 allele (APOE2) was associated with a somewhat reduced risk of @DISEASE$, but paradoxically was associated with increased Alzheimer disease (AD) neuropathology.

[ "0" ]

3872

Our results suggest MMP-2 and @GENE$ genotypes play a crucial role in @DISEASE$ invasion, but not with development of gastric cancer.

[ "1" ]

3873

These findings suggest that the @GENE$ gene is not primarily involved in susceptibility to @DISEASE$ in the Japanese population.

[ "1" ]

3874

The results suggest that existence of a @DISEASE$ in the @GENE$ gene is associated with an increased susceptibility to developing UC, especially chronic continuous distal colitis phenotypes that develop after 20 years of age.

[ "0" ]

3875

@GENE$ is a potential locus associated with @DISEASE$ in the Han Chinese population.

[ "0" ]

3876

There was no evidence in this study for the association of AGT M235T and @GENE$ I/D polymorphism with @DISEASE$ in Chinese population in Chengdu area.

[ "1" ]

3877

@GENE$ gene may contribute to the genetic susceptibility to @DISEASE$ in Han population.

[ "1" ]

3878

In patients with CHF, the presence of @DISEASE$ was significantly associated with certain ACE and @GENE$ genotypes.

[ "1" ]

3879

The significant association of @DISEASE$ with the @GENE$*3 allele encoding a low detoxification activity protein is identified and implicates UGT1A7 as a risk gene of hepatocarcinogenesis in addition to a role as potential marker for cancer risk assessment in chronic liver disease.

[ "1" ]

3880

Compared to a previous smaller study of @GENE$ receptor blockade in @DISEASE$, we could not confirm that CYP11B2 -344T/C genotypes contribute towards explaining the observed variability in response to treatment with angiotensin II receptor blockers, which could be due to lack of power.

[ "0" ]

3881

Our results do not show that @GENE$-173 gene polymorphism may infer a direct risk for @DISEASE$ susceptibility or CV disease in patients with RA.

[ "0" ]

3882

@GENE$ gene may be not a susceptibility gene of @DISEASE$ patients of Han population in southwest China.

[ "1" ]

3883

The results indicate that the increase in allelic frequency of 1166C is a risk factor and hence suggest that the change in the @GENE$ type I receptor gene is associated with @DISEASE$.

[ "0" ]

3884

We have failed to confirm the association between the @GENE$ gene polymorphism and @DISEASE$ susceptibility or severity.

[ "1" ]

3885

The @GENE$ 1908C/T polymorphism plays an important role in the development of cerebral @DISEASE$ and diabetic nephropathy in Japanese men with type 2 diabetes.

[ "0" ]

3886

Mutational analysis of the @GENE$ gene in a series of Italian patients revealed one @DISEASE$ and confirmed an important role played by this gene in a significant proportion of patients affected by keratoconus, when it is inherited as an autosomal dominant trait with variable expressivity and incomplete penetrance.

[ "0" ]

3887

These data indicate that genetic variants in @GENE$ have pharmacogenetic effects influencing @DISEASE$ response to corticosteroids, provide a rationale for predicting therapeutic response in asthma and other corticosteroid-treated diseases, and suggests this gene pathway as a potential novel therapeutic target.

[ "1" ]

3888

that the 1858C/T allele is the major risk variant for type 1 diabetes in the PTPN22 locus, but they suggest that additional infrequent coding variants at @GENE$ may also contribute to @DISEASE$ risk.

[ "1" ]

3889

Our results do not support a role for -94ins/delATTG @GENE$ promoter polymorphism in susceptibility and clinical expression of @DISEASE$ in a Northwestern Spanish population.

[ "1" ]

3890

The Gly49 allele in the beta1-adrenergic receptor and the 5' LC-Cys19, Arg16, and Gln27 alleles in the @GENE$-adrenergic receptor were associated with a lower risk of @DISEASE$ in idiopathic dilated cardiomyopathy, suggesting that the beta1- and beta2-adrenergic receptor genes are modifier genes.

[ "0" ]

3891

The @GENE$ polymorphisms studied do not contribute to disease susceptibility in Japanese or Dutch @DISEASE$ patients.

[ "1" ]

3892

Given the pivotal role of LDH in the metabolism of lactate, a known inducer of @DISEASE$, and the dependence of LDH activity on @GENE$ pH, we suggest that LDHA polymorphisms may contribute to the variability to CO(2) respiratory challenge.

[ "0" ]

3893

from this study may provide further evidence that @GENE$ M129V is not a genetic susceptibility factor for @DISEASE$, MCI, alcoholism and schizophrenia in a Korean population.

[ "0" ]

3894

Our results suggest that homozygosity for 3435T alleles of ABCB1 is a risk factor for occurrence of nortriptyline-induced postural @DISEASE$ (@GENE$, P = 0.042, 95% CI 1.01-1.86).

[ "0" ]

3895

@GENE$ polymorphisms may have a significant modifying effect on @DISEASE$ risk, which may interact with environmental factors, cigarette smoking and alcohol drinking in colorectal carcinogenesis.

[ "1" ]

3896

in the investigated German sample, no evidence of association of ABCB11 and @GENE$ to @DISEASE$ susceptibility was detected.

[ "1" ]

3897

The @GENE$ missense variant P1054R confers an about twofold increased risk for @DISEASE$ in our series.

[ "1" ]

3898

The results suggest that the 5A/6A polymorphism of @GENE$ gene may not be linked with appearance and/or @DISEASE$ of ovarian cancer.

[ "0" ]

3899

The @GENE$ C(-260)T polymorphism is associated with a history of ACS and it may represent a genetically determined risk factor for the development of ACS and @DISEASE$ vulnerability in angina patients.

[ "0" ]