bigbio/gad · Datasets at Hugging Face

id stringlengths 1 4	document_id stringlengths 1 4	text stringlengths 42 538	labels list
4100	4100	Our present data suggest that the matrix metalloproteinase-1 and @GENE$ promoter polymorphisms may not be useful markers to predicate susceptibility of @DISEASE$ in Chinese.	[ "1" ]
4101	4101	Our data indicate the possibility of linkage disequilibrium between the C270T variation and a @DISEASE$ in coding region of the @GENE$ gene and suggest that this gene may play a role in the development of familial PD.	[ "0" ]
4102	4102	Both analyses support (p = 0.046 for the proposed test, p = 0.028 for the case-control analysis) an association of the homozygous @GENE$ deletion genotype with @DISEASE$.	[ "1" ]
4103	4103	@GENE$ R192Q polymorphism could affect HDL-C levels after caloric restriction presumably due to decreased @DISEASE$ activity and altered insulin resistance.	[ "0" ]
4104	4104	These results suggest that homozygous C677T @GENE$ @DISEASE$ could be considered as a genetic risk factor for venous thrombosis.	[ "0" ]
4105	4105	A large deletion of exons 9 and 10 of @GENE$ confers an increased risk of @DISEASE$ in Polish men.	[ "1" ]
4106	4106	Drugs that are metabolized by @GENE$ increase the risk of @DISEASE$ in women.	[ "1" ]
4107	4107	These results call in question the hypothesis that either BDNF or @GENE$ can be used as molecular markers for @DISEASE$ or late onset depression in the elderly.	[ "1" ]
4108	4108	The CC genotype of the @GENE$ BstUI RFLP was underrepresented in female participants with @DISEASE$ cruciate ligament ruptures.	[ "0" ]
4109	4109	These results suggest that the @GENE$-I 4G/4G genotype is associated with @DISEASE$ in patients suffering from CAD.	[ "0" ]
4110	4110	Polymorphism of @GENE$ gene may contribute to the higher risk of @DISEASE$.	[ "0" ]
4111	4111	The findings suggest that specific polymorphisms in the @GENE$ and LEPR genes may play a role in @DISEASE$ of BBD to breast cancer among post-menopausal Caucasian women.	[ "0" ]
4112	4112	The study confers additional data in the field of genetic predisposition to @DISEASE$: it confirms the atheroprotective effect of the M280 variant in a completely different population and supports the role of the fractalkine-@GENE$ pathway in atherosclerosis.	[ "1" ]
4113	4113	Our results indicated that T869C polymorphism of TGF-beta1 gene might be associated with @DISEASE$ in female, furthermore, the TGF-beta1 T869C and @GENE$-344T/C polymorphisms appeared to interact in hypertensive population.	[ "0" ]
4114	4114	we report significant association of variants of @GENE$ with @DISEASE$ and ischemic stroke subtypes among whites.	[ "1" ]
4115	4115	In conclusion, our data suggest that @GENE$ polymorphism is a genetic modifier of the progression of @DISEASE$, possibly through inducing a partial defect in PD-1-mediated inhibition of T-cell activation.	[ "1" ]
4116	4116	In conclusion, @GENE$-176F/V polymorphism is not associated with @DISEASE$ in Koreans.	[ "1" ]
4117	4117	A decrease in WBC count and neutrophil count is found in patients with chronic benzene poisoning, which can arise from genetic @GENE$ in bone marrow stem cells, namely gene-duplicating mutations (NN) at the GPA locus in bone marrow cells of MN-heterozygous subjects, GPA-NN mutagens contributed to the @DISEASE$ of chronic benzene poisoning.	[ "0" ]
4118	4118	The @GENE$ Ala-9Val polymorphism may contribute to an increase in breast cancer risk in the context of high alcohol consumption, however the polymorphism is not an overall risk factor for @DISEASE$ in this primarily premenopausal population.	[ "1" ]
4119	4119	In spite of the limitation due to the small number of patients studied, we cannot confirm that @GENE$ e4 allele is a predictor of @DISEASE$ of disability in multiple sclerosis.	[ "0" ]
4120	4120	Our findings suggest that the preproghrelin gene 3056T-->C SNP is associated with changes in basal @GENE$ concentrations and physical and @DISEASE$ variables related to eating disorders and obesity.	[ "0" ]
4121	4121	In patients with @DISEASE$, the presence of @GENE$ was significantly associated with certain ACE and eNOS genotypes.	[ "0" ]
4122	4122	This study is the first to investigate the association between the @GENE$ CAG repeat polymorphism and the relative risk of @DISEASE$ in the Brazilian population.	[ "1" ]
4123	4123	These results suggest that the @GENE$ N367T and UGT2B17 null polymorphisms may modify the risk of prostate cancer, particularly among men with a family history of the @DISEASE$.	[ "0" ]
4124	4124	The @GENE$-159 SNP might not play a major role in the development of @DISEASE$ in German children.	[ "1" ]
4125	4125	our data suggests that the A2M D allele is a modest risk factor for late-onset sporadic @DISEASE$ in Koreans, and the AD risk conferred by the @GENE$ D allele increases in APOE epsilon4 negative subjects.	[ "1" ]
4126	4126	The Gly16 polymorphism of @GENE$ appears to be associated with nocturnal @DISEASE$.	[ "1" ]
4127	4127	These data suggest gender-specific gene-environment interaction between the CA repeat @GENE$ polymorphism and homocysteine in @DISEASE$.	[ "1" ]
4128	4128	These data suggest that mutations in @GENE$ can cause dopaminergic dysfunction, associated with @DISEASE$.	[ "1" ]
4129	4129	Our data suggest that a decreased expression of the gene encoding the @GENE$ transporter, due to "S" promoter polymorphism, may be associated with an increased availability to experiment illegal drugs among adolescents, particularly in the subjects with more consistent @DISEASE$, NS temperament and learning disabilities.	[ "0" ]
4130	4130	The results showed that the triplet repeat polymorphism in the promoter region of the @GENE$ gene was not likely to be involved in the @DISEASE$ or in the psychotic symptoms of mood disorders.	[ "0" ]
4131	4131	These data suggest that mutations in @GENE$ can cause dopaminergic @DISEASE$, associated with Parkinson disease.	[ "0" ]
4132	4132	The differences of @GENE$-159 C/T genotypes of SNPs may be associated with the higher risk of susceptibility and mortality of @DISEASE$.	[ "1" ]
4133	4133	These results indicate that mutations in NLGN3 and @GENE$ genes are responsible for at most a small fraction of autism cases and additional screenings in other @DISEASE$ populations are needed to better determine the frequency with which mutations in NLGN3 and NLGN4 occur in autism.	[ "1" ]
4134	4134	Polymorphisms in the oxidative stress-related genes (CYP1A1, GSTM1, GSTT1, MPO, @GENE$) do not seem to be risk factors for @DISEASE$.	[ "1" ]
4135	4135	Our results show that cigarette smoking is associated with an increase in @DISEASE$ risk among women with @GENE$ slow acetylation genotypes.	[ "1" ]
4136	4136	We conclude that -1989T/G or its linked polymorphisms in the @GENE$ gene may confer risk for CAD and that the G/G genotype may be an independent predictor for @DISEASE$ in patients with familial hypercholesterolemia.	[ "1" ]
4137	4137	We conclude that the @GENE$ -1612 5A/6A polymorphism is associated with MI in our population, implying that individuals of the 5A allele carriers have an increased risk of suffering @DISEASE$.	[ "1" ]
4138	4138	The results indicate that specific polymorphisms in the CYP1B1, @GENE$, and ESR2 genes may play a role in progression of BBD to @DISEASE$ among Caucasian women.	[ "1" ]
4139	4139	Our data suggest that the @GENE$ promoter pentanucleotide microsatellite polymorphisms analyzed do not play a major role in the @DISEASE$ of chronic T. cruzi infection in this Peruvian sample.	[ "0" ]
4140	4140	These results suggested never-smoking females with @GENE$ @DISEASE$ were more prone to lung cancer and reflected the possibility that exposure to heterocyclic amines may contribute to the female lung cancer development in Taiwan.	[ "0" ]
4141	4141	In conclusion, the @GENE$-308 (G/A) is likely to contribute to high risk for III/IV degree @DISEASE$ and extensive chronic GVHD.	[ "0" ]
4142	4142	@GENE$ * 0301 allele may be a correlative gene with hereditary susceptibility of EH, ABI and LS, and HLA-DQA1 * 0103 allele may be a protective gene of those @DISEASE$.	[ "0" ]
4143	4143	Together, our findings suggest that @GENE$ gene polymorphisms do not influence the susceptibility to @DISEASE$ or the clinical characteristics of MS in Japanese patients.	[ "1" ]
4144	4144	Thus, we could not confirm the results of a previous study reporting an association between the @GENE$ and IL-1 beta gene polymorphisms in patients with @DISEASE$.	[ "1" ]
4145	4145	Significant association between @GENE$ genotype and @DISEASE$ in Chinese women was observed in this study.	[ "1" ]
4146	4146	In conclusion, the paraoxonase -108 C-->T variant and the ApaI polymorphism in the @GENE$ gene are associated with PCOS and might contribute to increased @DISEASE$, insulin resistance, and hyperandrogenism in this prevalent disorder.	[ "0" ]
4147	4147	These results show that genetic variation in the @GENE$ encoding gene, which has been associated with altered activity of PXR, is strongly associated with susceptibility to @DISEASE$, CD, and UC.	[ "1" ]
4148	4148	Our data do not support the involvement of 5-HT(1B/1D) and @GENE$) receptor gene polymorphisms in @DISEASE$, yet do suggest a possible role for a locus at or near the hSERT gene in the susceptibility to migraine with aura.	[ "1" ]
4149	4149	This study shows that @GENE$ @DISEASE$ is an infrequent event and may have no essential role in recurrent nasopharyngeal carcinomas.	[ "0" ]
4150	4150	These findings indicate that @GENE$ exonic variants may contribute to the risk of lung cancer in the Chinese population, and these variant genotypes may modulate the risk of @DISEASE$ associated with smoking.	[ "1" ]
4151	4151	These data therefore confirm the importance of SLC11A1 in @DISEASE$ susceptibility in humans and suggest that @GENE$ influences tuberculosis susceptibility by regulation of interleukin-10.	[ "1" ]
4152	4152	Conditioned on maternal @GENE$ genotypes, fetal high IFN-gamma producing allele (IFN-gamma[+874T]) was associated with spontaneous @DISEASE$ (odds ratio = 2.3 [1.2-4.4]).	[ "0" ]
4153	4153	The results of this study suggest that @DISEASE$ in @GENE$ alone are not sufficient to cause POAG.	[ "0" ]
4154	4154	The current findings indicate that the IL-17F H161R variant influences the risk of asthma and is a natural @GENE$ antagonist, suggesting a potential role for IL-17F in the etiology of @DISEASE$.	[ "1" ]
4155	4155	These results suggest that the @GENE$ gene region may contribute to the @DISEASE$ of IDDM and could be a genetic marker for IDDM.	[ "0" ]
4156	4156	The 3'-@GENE$ of the CTLA4 gene is involved in susceptibility to @DISEASE$.	[ "0" ]
4157	4157	There was no evidence that risk of breast cancer depends on @GENE$ CAG/@DISEASE$ polymorphism status, even if affected women carry a mutation in BRCA1 or BRCA2.	[ "0" ]
4158	4158	the risk of @DISEASE$ for men in the presence of the @GENE$ allele of the His1299Arg polymorphism is neither increased nor decreased.	[ "0" ]
4159	4159	The -30G-->A polymorphism of the beta-cell-specific promoter of @GENE$ and the I27L polymorphism of HNF1A seem to increase the risk of @DISEASE$ in Scandinavian women.	[ "1" ]
4160	4160	Functional polymorphism in @GENE$ is associated with increased risk of @DISEASE$ in Chinese population.	[ "1" ]
4161	4161	In our population, we did not demonstrate any effect of the C34T polymorphism of the @GENE$ gene on major @DISEASE$ parameters and on survival.	[ "1" ]
4162	4162	@DISEASE$ @GENE$ allele may be considered a favorable prognostic factor in MS.	[ "0" ]
4163	4163	The results of this study suggest that polymorphisms in the human @GENE$ gene may represent risk factors for the development of bipolar disorder, but before such a role can be established, the results of this study must be confirmed in additional populations of @DISEASE$ patients and controls.	[ "1" ]
4164	4164	Our data suggested that a C to T substitution at the 5671 locus of the @GENE$ gene may be associated with @DISEASE$ during alcohol withdrawal.	[ "0" ]
4165	4165	These results demonstrate the association of a new polymorphism of @GENE$ (I232T) with susceptibility to @DISEASE$ in the Japanese.	[ "1" ]
4166	4166	Our results imply that @DISEASE$ caused by excess nitric oxide generated by @GENE$ contributes to Helicobacter pylori-induced gastric cancer.	[ "0" ]
4167	4167	Our results suggest that structural polymorphisms in the @GENE$ gene may be implicated in the @DISEASE$ of DSPS.	[ "0" ]
4168	4168	Our findings suggest that @GENE$ has an impact on the risk of @DISEASE$ and possibly plays a role in influencing AMA development as well as progression to OLT among PBC patients.	[ "0" ]
4169	4169	This study supports the hypothesis that there may be different types of small vessel @DISEASE$ in patients with classic lacunar syndromes and that the influence of the @GENE$ DD genotype may be relevant in mediating the diffuse form of vessel injury.	[ "0" ]
4170	4170	These results suggest that the SLC22A4, @GENE$, and SUMO4 polymorphisms analyzed do not confer a relevant role in susceptibility to @DISEASE$ in the Spanish population.	[ "1" ]
4171	4171	Current data provide limited support for the hypothesis that sequence variation in TGFBR1 defined by the @GENE$*6A allele confers an elevated risk of @DISEASE$.	[ "1" ]
4172	4172	We conclude that @GENE$ and TrkB genes are not contributing significant risk effect among Finnish @DISEASE$ patients.	[ "1" ]
4173	4173	In conclusion, while the @GENE$ I/D polymorphism promoted the progress of in-stent @DISEASE$ and was of clinical significance, the other potential variables examined did not correlate with in-stent restenosis.	[ "1" ]
4174	4174	These data suggest a role of the @GENE$ gene in the @DISEASE$ of metabolic syndrome in hypertensive patients.	[ "0" ]
4175	4175	@DISEASE$ @GENE$ isoenzyme does not seem to play a crucial role in the development of hypospadias.	[ "0" ]
4176	4176	This study confirms that Caucasian pediatric patients carrying the functional @GENE$ 4G/4G genotype are at an increased risk of developing vascular complications and dying from @DISEASE$.	[ "1" ]
4177	4177	Sequence variation in @GENE$ is not the major cause of radiotherapy complications in women with @DISEASE$.	[ "1" ]
4178	4178	we could not find evidence of association between @GENE$, PRODH, COMT and GRK3 genes and @DISEASE$ 1 in the Scottish population.	[ "1" ]
4179	4179	C1167 polymorphism in the @GENE$ gene and D6S366 near the SOD2 gene are not associated with the development of @DISEASE$ and diabetic retinopathy in IDDM.	[ "0" ]
4180	4180	As DKK family members have previously been found to show altered expression in schizophrenia brain and to bind to neuregulin, this finding suggests that @GENE$ may play a role in @DISEASE$ pathogenesis.	[ "1" ]
4181	4181	Variants in the regulatory region shared by @GENE$ and PACRG therefore act as common risk factors for @DISEASE$.	[ "1" ]
4182	4182	Our results demonstrate a gene dose effect of the DQB1*0201 allele on the clinical heterogeneity of @GENE$ and on the rate of recovery from villous @DISEASE$ in patients on a gluten-free diet.	[ "0" ]
4183	4183	@GENE$ genetic variations might play a role in regulating corticosteroid response in @DISEASE$ subjects with reduced lung function.	[ "1" ]
4184	4184	Polymorphism in @GENE$ may predispose to @DISEASE$ and GSTP1 may be a biological indicator of prognosis in the patients.	[ "1" ]
4185	4185	Although the strength of the associations was rather @DISEASE$, these observations raise the hypothesis that the G160A polymorphism of the @GENE$ gene plays a role in the development of human cardiac hypertrophy.	[ "0" ]
4186	4186	The data suggest that these promoter polymorphisms of the @GENE$ gene, both independently and cumulatively, show association with @DISEASE$.	[ "1" ]
4187	4187	These results suggest that the @GENE$ enzyme may have a role in the metabolism of dihydrotestosterone in prostate tissue and UGT2B15 Asp85Tyr polymorphism is associated with @DISEASE$ risk.	[ "1" ]
4188	4188	@GENE$ polymorphisms do not seem to be a risk factor for @DISEASE$ in Poles.	[ "0" ]
4189	4189	We found no significant association of @DISEASE$ with the trinucleotide repeat polymorphism of the reelin or @GENE$ genes, suggesting that these polymorphisms do not have a major role in the pathogenesis of the disease.	[ "1" ]
4190	4190	These data suggest that -838A is associated with reduced @GENE$ promoter activity and increased risk of @DISEASE$.	[ "1" ]
4191	4191	The present study confirms our previous @DISEASE$ and shows that polymorphism in the promoter region of @GENE$ is associated with vascular morphology in hypertensive subjects.	[ "0" ]
4192	4192	The results suggest that, in Japanese patients, micropenis can be caused by @GENE$ gene mutations, especially by R227Q which has been shown to retain approximately 3.2% of normal enzyme activity and appears relatively frequent in Asian populations, and that V89L polymorphism is unlikely to raise the susceptibility to the development of @DISEASE$.	[ "1" ]
4193	4193	In the @GENE$ of these observations it seems reasonable to make a preliminary conclusion about lack of association between @DISEASE$ and distinct polymorphisms of renin-angiotensin system genes in the population studied.	[ "0" ]
4194	4194	In summary, our results show that @DISEASE$ is a complex disease which is not only caused by mutations in @GENE$ and SLC3A1, but also influenced by other modifying factors such as variants in SLC7A9.	[ "1" ]
4195	4195	Thus, our results support a @DISEASE$ mechanism in SLE that involves key components of the @GENE$ I IFN system.	[ "0" ]
4196	4196	In our population, the +1073 C/T OLR1 polymorphism exhibited a significant association with Alzheimer's disease, further supporting the role of @GENE$ as a candidate risk gene for sporadic @DISEASE$.	[ "1" ]
4197	4197	This study provides preliminary and unconfirmed evidence for the involvement of the @GENE$ repeat VNTR in the @DISEASE$ of schizophrenia.	[ "0" ]
4198	4198	Our results show that the 4G/4G PAI-1 genotype appears to be associated with an elevated relative risk of developing arterial hypertension, regardless of @GENE$ levels and other @DISEASE$-related factors, in a representative sample of the Spanish population.	[ "1" ]
4199	4199	Together, our findings suggest that the presence of @GENE$ gene polymorphisms may be inconclusive in the susceptibility to @DISEASE$ or in the clinical characteristics of Japanese patients with MS and, therefore, need further studies.	[ "1" ]

4100

Our present data suggest that the matrix metalloproteinase-1 and @GENE$ promoter polymorphisms may not be useful markers to predicate susceptibility of @DISEASE$ in Chinese.

[ "1" ]

4101

Our data indicate the possibility of linkage disequilibrium between the C270T variation and a @DISEASE$ in coding region of the @GENE$ gene and suggest that this gene may play a role in the development of familial PD.

[ "0" ]

4102

Both analyses support (p = 0.046 for the proposed test, p = 0.028 for the case-control analysis) an association of the homozygous @GENE$ deletion genotype with @DISEASE$.

[ "1" ]

4103

@GENE$ R192Q polymorphism could affect HDL-C levels after caloric restriction presumably due to decreased @DISEASE$ activity and altered insulin resistance.

[ "0" ]

4104

These results suggest that homozygous C677T @GENE$ @DISEASE$ could be considered as a genetic risk factor for venous thrombosis.

[ "0" ]

4105

A large deletion of exons 9 and 10 of @GENE$ confers an increased risk of @DISEASE$ in Polish men.

[ "1" ]

4106

Drugs that are metabolized by @GENE$ increase the risk of @DISEASE$ in women.

[ "1" ]

4107

These results call in question the hypothesis that either BDNF or @GENE$ can be used as molecular markers for @DISEASE$ or late onset depression in the elderly.

[ "1" ]

4108

The CC genotype of the @GENE$ BstUI RFLP was underrepresented in female participants with @DISEASE$ cruciate ligament ruptures.

[ "0" ]

4109

These results suggest that the @GENE$-I 4G/4G genotype is associated with @DISEASE$ in patients suffering from CAD.

[ "0" ]

4110

Polymorphism of @GENE$ gene may contribute to the higher risk of @DISEASE$.

[ "0" ]

4111

The findings suggest that specific polymorphisms in the @GENE$ and LEPR genes may play a role in @DISEASE$ of BBD to breast cancer among post-menopausal Caucasian women.

[ "0" ]

4112

The study confers additional data in the field of genetic predisposition to @DISEASE$: it confirms the atheroprotective effect of the M280 variant in a completely different population and supports the role of the fractalkine-@GENE$ pathway in atherosclerosis.

[ "1" ]

4113

Our results indicated that T869C polymorphism of TGF-beta1 gene might be associated with @DISEASE$ in female, furthermore, the TGF-beta1 T869C and @GENE$-344T/C polymorphisms appeared to interact in hypertensive population.

[ "0" ]

4114

we report significant association of variants of @GENE$ with @DISEASE$ and ischemic stroke subtypes among whites.

[ "1" ]

4115

In conclusion, our data suggest that @GENE$ polymorphism is a genetic modifier of the progression of @DISEASE$, possibly through inducing a partial defect in PD-1-mediated inhibition of T-cell activation.

[ "1" ]

4116

In conclusion, @GENE$-176F/V polymorphism is not associated with @DISEASE$ in Koreans.

[ "1" ]

4117

A decrease in WBC count and neutrophil count is found in patients with chronic benzene poisoning, which can arise from genetic @GENE$ in bone marrow stem cells, namely gene-duplicating mutations (NN) at the GPA locus in bone marrow cells of MN-heterozygous subjects, GPA-NN mutagens contributed to the @DISEASE$ of chronic benzene poisoning.

[ "0" ]

4118

The @GENE$ Ala-9Val polymorphism may contribute to an increase in breast cancer risk in the context of high alcohol consumption, however the polymorphism is not an overall risk factor for @DISEASE$ in this primarily premenopausal population.

[ "1" ]

4119

In spite of the limitation due to the small number of patients studied, we cannot confirm that @GENE$ e4 allele is a predictor of @DISEASE$ of disability in multiple sclerosis.

[ "0" ]

4120

Our findings suggest that the preproghrelin gene 3056T-->C SNP is associated with changes in basal @GENE$ concentrations and physical and @DISEASE$ variables related to eating disorders and obesity.

[ "0" ]

4121

In patients with @DISEASE$, the presence of @GENE$ was significantly associated with certain ACE and eNOS genotypes.

[ "0" ]

4122

This study is the first to investigate the association between the @GENE$ CAG repeat polymorphism and the relative risk of @DISEASE$ in the Brazilian population.

[ "1" ]

4123

These results suggest that the @GENE$ N367T and UGT2B17 null polymorphisms may modify the risk of prostate cancer, particularly among men with a family history of the @DISEASE$.

[ "0" ]

4124

The @GENE$-159 SNP might not play a major role in the development of @DISEASE$ in German children.

[ "1" ]

4125

our data suggests that the A2M D allele is a modest risk factor for late-onset sporadic @DISEASE$ in Koreans, and the AD risk conferred by the @GENE$ D allele increases in APOE epsilon4 negative subjects.

[ "1" ]

4126

The Gly16 polymorphism of @GENE$ appears to be associated with nocturnal @DISEASE$.

[ "1" ]

4127

These data suggest gender-specific gene-environment interaction between the CA repeat @GENE$ polymorphism and homocysteine in @DISEASE$.

[ "1" ]

4128

These data suggest that mutations in @GENE$ can cause dopaminergic dysfunction, associated with @DISEASE$.

[ "1" ]

4129

Our data suggest that a decreased expression of the gene encoding the @GENE$ transporter, due to "S" promoter polymorphism, may be associated with an increased availability to experiment illegal drugs among adolescents, particularly in the subjects with more consistent @DISEASE$, NS temperament and learning disabilities.

[ "0" ]

4130

The results showed that the triplet repeat polymorphism in the promoter region of the @GENE$ gene was not likely to be involved in the @DISEASE$ or in the psychotic symptoms of mood disorders.

[ "0" ]

4131

These data suggest that mutations in @GENE$ can cause dopaminergic @DISEASE$, associated with Parkinson disease.

[ "0" ]

4132

The differences of @GENE$-159 C/T genotypes of SNPs may be associated with the higher risk of susceptibility and mortality of @DISEASE$.

[ "1" ]

4133

These results indicate that mutations in NLGN3 and @GENE$ genes are responsible for at most a small fraction of autism cases and additional screenings in other @DISEASE$ populations are needed to better determine the frequency with which mutations in NLGN3 and NLGN4 occur in autism.

[ "1" ]

4134

Polymorphisms in the oxidative stress-related genes (CYP1A1, GSTM1, GSTT1, MPO, @GENE$) do not seem to be risk factors for @DISEASE$.

[ "1" ]

4135

Our results show that cigarette smoking is associated with an increase in @DISEASE$ risk among women with @GENE$ slow acetylation genotypes.

[ "1" ]

4136

We conclude that -1989T/G or its linked polymorphisms in the @GENE$ gene may confer risk for CAD and that the G/G genotype may be an independent predictor for @DISEASE$ in patients with familial hypercholesterolemia.

[ "1" ]

4137

We conclude that the @GENE$ -1612 5A/6A polymorphism is associated with MI in our population, implying that individuals of the 5A allele carriers have an increased risk of suffering @DISEASE$.

[ "1" ]

4138

The results indicate that specific polymorphisms in the CYP1B1, @GENE$, and ESR2 genes may play a role in progression of BBD to @DISEASE$ among Caucasian women.

[ "1" ]

4139

Our data suggest that the @GENE$ promoter pentanucleotide microsatellite polymorphisms analyzed do not play a major role in the @DISEASE$ of chronic T. cruzi infection in this Peruvian sample.

[ "0" ]

4140

These results suggested never-smoking females with @GENE$ @DISEASE$ were more prone to lung cancer and reflected the possibility that exposure to heterocyclic amines may contribute to the female lung cancer development in Taiwan.

[ "0" ]

4141

In conclusion, the @GENE$-308 (G/A) is likely to contribute to high risk for III/IV degree @DISEASE$ and extensive chronic GVHD.

[ "0" ]

4142

@GENE$ * 0301 allele may be a correlative gene with hereditary susceptibility of EH, ABI and LS, and HLA-DQA1 * 0103 allele may be a protective gene of those @DISEASE$.

[ "0" ]

4143

Together, our findings suggest that @GENE$ gene polymorphisms do not influence the susceptibility to @DISEASE$ or the clinical characteristics of MS in Japanese patients.

[ "1" ]

4144

Thus, we could not confirm the results of a previous study reporting an association between the @GENE$ and IL-1 beta gene polymorphisms in patients with @DISEASE$.

[ "1" ]

4145

Significant association between @GENE$ genotype and @DISEASE$ in Chinese women was observed in this study.

[ "1" ]

4146

In conclusion, the paraoxonase -108 C-->T variant and the ApaI polymorphism in the @GENE$ gene are associated with PCOS and might contribute to increased @DISEASE$, insulin resistance, and hyperandrogenism in this prevalent disorder.

[ "0" ]

4147

These results show that genetic variation in the @GENE$ encoding gene, which has been associated with altered activity of PXR, is strongly associated with susceptibility to @DISEASE$, CD, and UC.

[ "1" ]

4148

Our data do not support the involvement of 5-HT(1B/1D) and @GENE$) receptor gene polymorphisms in @DISEASE$, yet do suggest a possible role for a locus at or near the hSERT gene in the susceptibility to migraine with aura.

[ "1" ]

4149

This study shows that @GENE$ @DISEASE$ is an infrequent event and may have no essential role in recurrent nasopharyngeal carcinomas.

[ "0" ]

4150

These findings indicate that @GENE$ exonic variants may contribute to the risk of lung cancer in the Chinese population, and these variant genotypes may modulate the risk of @DISEASE$ associated with smoking.

[ "1" ]

4151

These data therefore confirm the importance of SLC11A1 in @DISEASE$ susceptibility in humans and suggest that @GENE$ influences tuberculosis susceptibility by regulation of interleukin-10.

[ "1" ]

4152

Conditioned on maternal @GENE$ genotypes, fetal high IFN-gamma producing allele (IFN-gamma[+874T]) was associated with spontaneous @DISEASE$ (odds ratio = 2.3 [1.2-4.4]).

[ "0" ]

4153

The results of this study suggest that @DISEASE$ in @GENE$ alone are not sufficient to cause POAG.

[ "0" ]

4154

The current findings indicate that the IL-17F H161R variant influences the risk of asthma and is a natural @GENE$ antagonist, suggesting a potential role for IL-17F in the etiology of @DISEASE$.

[ "1" ]

4155

These results suggest that the @GENE$ gene region may contribute to the @DISEASE$ of IDDM and could be a genetic marker for IDDM.

[ "0" ]

4156

The 3'-@GENE$ of the CTLA4 gene is involved in susceptibility to @DISEASE$.

[ "0" ]

4157

There was no evidence that risk of breast cancer depends on @GENE$ CAG/@DISEASE$ polymorphism status, even if affected women carry a mutation in BRCA1 or BRCA2.

[ "0" ]

4158

the risk of @DISEASE$ for men in the presence of the @GENE$ allele of the His1299Arg polymorphism is neither increased nor decreased.

[ "0" ]

4159

The -30G-->A polymorphism of the beta-cell-specific promoter of @GENE$ and the I27L polymorphism of HNF1A seem to increase the risk of @DISEASE$ in Scandinavian women.

[ "1" ]

4160

Functional polymorphism in @GENE$ is associated with increased risk of @DISEASE$ in Chinese population.

[ "1" ]

4161

In our population, we did not demonstrate any effect of the C34T polymorphism of the @GENE$ gene on major @DISEASE$ parameters and on survival.

[ "1" ]

4162

@DISEASE$ @GENE$ allele may be considered a favorable prognostic factor in MS.

[ "0" ]

4163

The results of this study suggest that polymorphisms in the human @GENE$ gene may represent risk factors for the development of bipolar disorder, but before such a role can be established, the results of this study must be confirmed in additional populations of @DISEASE$ patients and controls.

[ "1" ]

4164

Our data suggested that a C to T substitution at the 5671 locus of the @GENE$ gene may be associated with @DISEASE$ during alcohol withdrawal.

[ "0" ]

4165

These results demonstrate the association of a new polymorphism of @GENE$ (I232T) with susceptibility to @DISEASE$ in the Japanese.

[ "1" ]

4166

Our results imply that @DISEASE$ caused by excess nitric oxide generated by @GENE$ contributes to Helicobacter pylori-induced gastric cancer.

[ "0" ]

4167

Our results suggest that structural polymorphisms in the @GENE$ gene may be implicated in the @DISEASE$ of DSPS.

[ "0" ]

4168

Our findings suggest that @GENE$ has an impact on the risk of @DISEASE$ and possibly plays a role in influencing AMA development as well as progression to OLT among PBC patients.

[ "0" ]

4169

This study supports the hypothesis that there may be different types of small vessel @DISEASE$ in patients with classic lacunar syndromes and that the influence of the @GENE$ DD genotype may be relevant in mediating the diffuse form of vessel injury.

[ "0" ]

4170

These results suggest that the SLC22A4, @GENE$, and SUMO4 polymorphisms analyzed do not confer a relevant role in susceptibility to @DISEASE$ in the Spanish population.

[ "1" ]

4171

Current data provide limited support for the hypothesis that sequence variation in TGFBR1 defined by the @GENE$*6A allele confers an elevated risk of @DISEASE$.

[ "1" ]

4172

We conclude that @GENE$ and TrkB genes are not contributing significant risk effect among Finnish @DISEASE$ patients.

[ "1" ]

4173

In conclusion, while the @GENE$ I/D polymorphism promoted the progress of in-stent @DISEASE$ and was of clinical significance, the other potential variables examined did not correlate with in-stent restenosis.

[ "1" ]

4174

These data suggest a role of the @GENE$ gene in the @DISEASE$ of metabolic syndrome in hypertensive patients.

[ "0" ]

4175

@DISEASE$ @GENE$ isoenzyme does not seem to play a crucial role in the development of hypospadias.

[ "0" ]

4176

This study confirms that Caucasian pediatric patients carrying the functional @GENE$ 4G/4G genotype are at an increased risk of developing vascular complications and dying from @DISEASE$.

[ "1" ]

4177

Sequence variation in @GENE$ is not the major cause of radiotherapy complications in women with @DISEASE$.

[ "1" ]

4178

we could not find evidence of association between @GENE$, PRODH, COMT and GRK3 genes and @DISEASE$ 1 in the Scottish population.

[ "1" ]

4179

C1167 polymorphism in the @GENE$ gene and D6S366 near the SOD2 gene are not associated with the development of @DISEASE$ and diabetic retinopathy in IDDM.

[ "0" ]

4180

As DKK family members have previously been found to show altered expression in schizophrenia brain and to bind to neuregulin, this finding suggests that @GENE$ may play a role in @DISEASE$ pathogenesis.

[ "1" ]

4181

Variants in the regulatory region shared by @GENE$ and PACRG therefore act as common risk factors for @DISEASE$.

[ "1" ]

4182

Our results demonstrate a gene dose effect of the DQB1*0201 allele on the clinical heterogeneity of @GENE$ and on the rate of recovery from villous @DISEASE$ in patients on a gluten-free diet.

[ "0" ]

4183

@GENE$ genetic variations might play a role in regulating corticosteroid response in @DISEASE$ subjects with reduced lung function.

[ "1" ]

4184

Polymorphism in @GENE$ may predispose to @DISEASE$ and GSTP1 may be a biological indicator of prognosis in the patients.

[ "1" ]

4185

Although the strength of the associations was rather @DISEASE$, these observations raise the hypothesis that the G160A polymorphism of the @GENE$ gene plays a role in the development of human cardiac hypertrophy.

[ "0" ]

4186

The data suggest that these promoter polymorphisms of the @GENE$ gene, both independently and cumulatively, show association with @DISEASE$.

[ "1" ]

4187

These results suggest that the @GENE$ enzyme may have a role in the metabolism of dihydrotestosterone in prostate tissue and UGT2B15 Asp85Tyr polymorphism is associated with @DISEASE$ risk.

[ "1" ]

4188

@GENE$ polymorphisms do not seem to be a risk factor for @DISEASE$ in Poles.

[ "0" ]

4189

We found no significant association of @DISEASE$ with the trinucleotide repeat polymorphism of the reelin or @GENE$ genes, suggesting that these polymorphisms do not have a major role in the pathogenesis of the disease.

[ "1" ]

4190

These data suggest that -838A is associated with reduced @GENE$ promoter activity and increased risk of @DISEASE$.

[ "1" ]

4191

The present study confirms our previous @DISEASE$ and shows that polymorphism in the promoter region of @GENE$ is associated with vascular morphology in hypertensive subjects.

[ "0" ]

4192

The results suggest that, in Japanese patients, micropenis can be caused by @GENE$ gene mutations, especially by R227Q which has been shown to retain approximately 3.2% of normal enzyme activity and appears relatively frequent in Asian populations, and that V89L polymorphism is unlikely to raise the susceptibility to the development of @DISEASE$.

[ "1" ]

4193

In the @GENE$ of these observations it seems reasonable to make a preliminary conclusion about lack of association between @DISEASE$ and distinct polymorphisms of renin-angiotensin system genes in the population studied.

[ "0" ]

4194

In summary, our results show that @DISEASE$ is a complex disease which is not only caused by mutations in @GENE$ and SLC3A1, but also influenced by other modifying factors such as variants in SLC7A9.

[ "1" ]

4195

Thus, our results support a @DISEASE$ mechanism in SLE that involves key components of the @GENE$ I IFN system.

[ "0" ]

4196

In our population, the +1073 C/T OLR1 polymorphism exhibited a significant association with Alzheimer's disease, further supporting the role of @GENE$ as a candidate risk gene for sporadic @DISEASE$.

[ "1" ]

4197

This study provides preliminary and unconfirmed evidence for the involvement of the @GENE$ repeat VNTR in the @DISEASE$ of schizophrenia.

[ "0" ]

4198

Our results show that the 4G/4G PAI-1 genotype appears to be associated with an elevated relative risk of developing arterial hypertension, regardless of @GENE$ levels and other @DISEASE$-related factors, in a representative sample of the Spanish population.

[ "1" ]

4199

Together, our findings suggest that the presence of @GENE$ gene polymorphisms may be inconclusive in the susceptibility to @DISEASE$ or in the clinical characteristics of Japanese patients with MS and, therefore, need further studies.

[ "1" ]