Commit
•
77440de
1
Parent(s):
39be509
Upload README.md with huggingface_hub
Browse files
README.md
CHANGED
@@ -22,6 +22,10 @@ extra_gated_fields:
|
|
22 |
|
23 |
This repository contains data on the change in protein stability with a single mutation.
|
24 |
|
|
|
|
|
|
|
|
|
25 |
## Attribution of Data Sources
|
26 |
|
27 |
- **Primary Source**: Tsuboyama, K., Dauparas, J., Chen, J. et al. Mega-scale experimental analysis of protein folding stability in biology and design. Nature 620, 434–444 (2023). [Link to the paper](https://www.nature.com/articles/s41586-023-06328-6)
|
@@ -67,4 +71,5 @@ The **delta delta G** (ΔΔG) represents the deltaG of the mutation compared to
|
|
67 |
### Data Cleanup and Validation:
|
68 |
|
69 |
1. Filtering: The dataset has been curated to only include examples of single mutations.
|
70 |
-
2.
|
|
|
|
22 |
|
23 |
This repository contains data on the change in protein stability with a single mutation.
|
24 |
|
25 |
+
There are two datasets:
|
26 |
+
- [Sample dataset, ~100 datapoints](https://huggingface.co/datasets/Trelis/protein_stability_single_mutation_SAMPLE).
|
27 |
+
- [Gated dataset, ~250k datapoints](https://huggingface.co/datasets/Trelis/protein_stability_single_mutation).
|
28 |
+
|
29 |
## Attribution of Data Sources
|
30 |
|
31 |
- **Primary Source**: Tsuboyama, K., Dauparas, J., Chen, J. et al. Mega-scale experimental analysis of protein folding stability in biology and design. Nature 620, 434–444 (2023). [Link to the paper](https://www.nature.com/articles/s41586-023-06328-6)
|
|
|
71 |
### Data Cleanup and Validation:
|
72 |
|
73 |
1. Filtering: The dataset has been curated to only include examples of single mutations.
|
74 |
+
2. Sequence mutations were extracted from the row names. Base mutations are labelled as 'base'.
|
75 |
+
3. Consistency Check: Only rows with a consistent 'mutation', aligned with both the base and mutated sequences from the raw data, have been retained.
|