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PMC11596967
Reactive oxygen species (ROS), byproducts of cellular metabolism and environmental factors, are linked to diseases like cancer and aging.
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PMC9429973
Novel targeted therapies have been shown to improve outcomes in pts with adult B-ALL.
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PMC10944868
In humans, 23 functional tubulin genes contribute to the structural complexity of microtubules, characterized by the assembly of α-β tubulin heterodimers into linear protofilaments.
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PMC8526701
D GIST-T1 cells were treated with GSK602 at indicated concentrations for 24 h. The expression of PUMA was analyzed by western blotting.
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PMC11612315
It is derived from exendin-4 through N-terminal truncation and shares 53% sequence homology with native GLP-1.
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PMC10366908
In this study, we developed novel anti-mEGFR mAbs using the CBIS method and evaluated its applications including flow cytometry.
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PMC10976516
So chemotherapy certainly remains an important partner in combination with OV therapy too, although more clinical data are needed to substantiate this.
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PMC11512230
Maybe more research may be carried out to examine these particles’ potentials for use with different kinds of tumors.
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PMC8701144
SIM images are specified in the figure legends.
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PMC11291490
The immunostimulatory properties of CD40L have been harnessed to bolster B- and T-cell responses across various vaccination strategies in mammalian species.
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PMC11575040
Their findings revealed that aberrant expression of CENPM was significantly associated with poor overall survival in melanoma patients.
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PMC9429973
Methods: We performed a retrospective analysis of patients diagnosed with SMM at Memorial Sloan Kettering Cancer Center between January 2000 and December 2017.
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PMC11731614
Using size exclusion chromatography, we obtained enriched KDEVs from mice and performed an unbiased molecular cargo characterization with proteomic analysis and small RNA sequencing.
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PMC8839885
The different cells were exposed to RJY13 for 6 h and the intracellular level of platinum was monitored.
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PMC11190538
The stirred yoghurts were all enhanced with 0.75 % blueberry flavor.
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PMC11240052
Illumina Small RNA v1.5 Sample Preparation kit (Illumina, Inc.).
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PMC9351137
After several washes in PBS, the cells were incubated with secondary antibodies for 1 h at RT.
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PMC9429973
The prognosis of PMF is variable and clearly worsens with evolution of specific factors which accelerate disease progression.
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PMC10452486
However, HCs can also independently emerge unfolded on the cell surface without peptides as B2m-free HC monomers (Face-2), B2m-free HC homodimers (Face 3), and B2m-free HC heterodimers (Face-4).
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PMC5173112
Mechanistically, USP21 binds to the promoter region of IL-8 and mediates transcriptional initiation.
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PMC11769516
The toxic effect of these compounds leads to disturbances in the metabolism of fats, proteins and carbohydrates as well as the synthesis of nucleic acids, leading to the development of cancer, e.g., of the kidneys or liver.
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PMC11678448
Determine hub genes by using the MCC algorithm in the CytoHubba plugin.
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PMC11769516
Most of the analyzed combinations showed synergistic or additive effects, but the combinations of ENNB + STG, ENNB + AFB1 and CPZ + CIT showed antagonistic interactions .
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PMC10870498
Red represents up-regulated genes and blue represents down-regulated genes; B The expression of KIF23 in 510 cancer and 58 normal samples in THCA was analyzed by the starbase database; C RT-qPCR assay was performed to analyze the expression level of KIF23 in ATC cells (TPC1, 8305C, 8505C, BCPAP) and thyroid epithelial cell-derived cell line (HTori3). (*
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PMC11767725
In contrast, rosacea exhibited a weaker association with MetS, with an odds ratio (OR) of 1.56 (95% CI: 0.96–2.52).
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PMC11502327
In the past few decades, nanotechnology has been absorbing technical solutions from different subdisciplines and has been widely used, especially in the fields of biology, medicine, and materials.
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PMC4395774
The features of HLH in the murine system accurately recapitulate human disease and include significant immune dysregulation with hypercytokinemia, macrophage activation, and cytopenias.
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PMC11806818
The preparation process of Apt/Fe-N-C SAzymes and the principle of colorimetric detection of cancer cells.
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PMC11774112
CMC of Co-PHRD micelles determined using fluorescence spectra of the pyrene probe at different concentrations of PHRD (1× 10 - 2.0 mg/mL). (
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PMC11228511
Indeed, we found nuclear blebs in SMCs in the aorta of 10-wk-old Lmna mice (Fig. 6F and SI Appendix, Fig. S3B).
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PMC10560648
For instance, the potential of C. Andromeda venom to cause apoptosis and cytotoxicity through mitochondrial pathway in human breast adenocarcinoma tissue have been shown in previous studies .
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PMC7723249
After treatment, compounds were removed and cells were infected apically with HAZV or CCHFV at a MOI of 1 in 1 ml culture medium without FBS for 1 hour.
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PMC11772585
After allowing the cells to adhere to the culture surface, 2 × 10 cells were collected in a centrifuge tube and centrifuged at 1000 rpm.
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PMC11464609
Moreover, de novo assembly resulted in larger contiguous fragments compared to conventional metagenomics (mean N50: 12257 vs. 1741 bp, p = 0.03, t test).
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PMC8735881
In humanized mice, CD4 T cells expressing C34-CXCR4 were highly resistant to HIV-1 infection and had a selective survival advantage, and it has now been advanced to clinical trials .
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PMC11655536
ND, newly diagnostic multiple myeloma.
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PMC11665555
Importantly, the indicated overexpression of their targets would suggest reduced repressor activity.
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PMC9429973
In addition, 8 pts (19%) had secondary cancer before the MN diagnosis (2 pts lymphoma, 2 pts skin cancer, ovary Ca, uterine Ca, schwannoma, and adrenal tumor) and 3 of them received therapy (chemotherapy and/or radiation therapy).
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PMC10443665
P < 0.05 Indicates significant differences in comparison with the control group (CCRF-CEM cells); and also P < 0.05 vs CCRF-CEM/R cells.
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PMC11731614
We used the following antibodies on primary DRG cultures with a dilution of 1:1000: GFP (Abcam ab13970), β-tubulin (ProteinTech 80713–1-RR100UL).
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PMC9635307
Our interpretation of such conflicting results is that CEACAM1 has two distinct functions on B cell proliferation.
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PMC11568601
The identified mRNA and protein expression associated with the IRE1/CHOP pathway was validated by RT-PCR and western blot assay.
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PMC11759751
We successfully constructed CD19 CAR T cells with transfection efficiency of 57.7%, 54.1% and 55.5%, respectively (Fig. 1A).
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PMC10606998
In vitro studies of the effect of a system of nanoparticles in combination with radiation therapy on cell viability were carried out earlier in a number of works .
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PMC10988555
The dilution effect because of the addition of the DNA solution was corrected and the affinity constants were calculated according to eq 2:2where [DNA] is the concentration of CT-DNA (per nucleotide phosphate), εa = Abs/[complex], εf is the extinction coefficient for the free complex, and εb is the extinction coefficient for [Co(η-C5H5)(PPh3)(NN)][(CF3SO3)2] when fully bound to DNA.
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PMC9412887
Encouraged by the in vitro antitumor effect of DOX-PLGA/CPT/PD, Yu et al. evaluated the in vivo effect in MCF-7/ADR cell-bearing mice.
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PMC11248911
To determine the effect of each synthesized compound on membrane permeability in MCF-7 cancer cell line as well as BJ-1 normal cell line, a lactate dehydrogenase (LDH) release assay was used.
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PMC11106977
In recent years, multiple studies have demonstrated that O-GlcNAcylation plays a crucial role in regulating the dynamic balance of the bone matrix, ultimately constituting a complex network involved in bone metabolism.
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PMC9429973
Results: The relative risk (RR) of developing stomatitis in the combined NS group was lower than in the group without combined NS: RR=0.67 (95% CI 0.49-0.92), p=0.015.
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PMC11767817
Furthermore, to compare the potential pro-apoptotic/necrotic activity between the two compounds, we used the same concentrations (2 µM and 4 µM) for both compounds.
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PMC11063646
Pvt.
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PMC11638255
In patients with Wilson’s disease, copper chelation therapy can generate bursts of free copper levels which can often induce toxic side effects.
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PMC8806312
A total of 2498 genes from the ImmPort Shared Data were identified as IRGs.
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PMC11155445
Novel acyl thiourea derivatives (145a–g) were synthesized and investigated against aldose reductase (AR), sorbitol dehydrogenase (SDH) and α-glucosidase enzymes by Ertano et al. All compounds showed good inhibition activity toward AR and SDH enzymes, compound (145c) (Ki: 0.200 ± 0.024 μM) was found most potent against the AR enzyme.
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PMC11538390
These health data are continuously updated through periodical linking to national electronic databases and registries.
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PMC9429973
and Daniela Melo’s PhD Grant (SFRH/BD/139622/2018).
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PMC10850553
Finally, the signal was detected by a chemiluminescent reagent (ECL Prime Western Blotting Detection System, #RPN2236, GE healthcare).
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PMC9960565
The DNA binding constant (Kb) of the compounds with CT-DNA was determined with UV-Vis spectroscopy through the Benesi–Hildebrand equation, specifically from the ratio of the y-intercept to the slope in the plots A0/A − A0 vs. 1/[DNA] .
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PMC6133382
As these bN-mAbs were being described, the data from the RV144 HIV vaccine trial were released.
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PMC11723947
Cells were then labeled with BV750-conjugated anti-IFN-γ, APC-R700-coupled anti-IL-2, BV605-labeled anti-IL-17A, FITC-conjugated anti-TNF (MP6 XT22, BD Biosciences) and APC-coupled anti-GM-CSF antibodies using the Cytofix/Cytoperm Fixation/Permeabilization kit (BD Biosciences).
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PMC10988555
When the substrate is cleaved by caspase 8, pNA is released and can be quantified by measuring the absorbance at 400 nm.
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PMC11628904
This concept originates from the description by Jackson of the zones of burn injury.
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PMC5363531
The sarcomatoid histotype is the least common (5% of the patients), immortalized sarcomatoid cell lines are very difficult to obtain, and some of those commercially available lack clear-cut distinct features.
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PMC11741906
Consistent with our results, studies reported an enrichment of miRNAs regulating the MAPK pathway in cisplatin and taxane-resistant ovarian cancer cells .
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PMC11734514
Additionally, wound healing and invasion assays will be conducted to assess the ability of A549 cells after the treatment.
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PMC9429973
The model was tested in the validation cohort and sub-analyses for each method were conducted in a similar fashion.
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PMC11697189
Fig. 9HSPA7 promotes the proliferation, invasion and metastasis of A498 and ORSC2 cells, A498 cells were transfected with HSPA7-specific siRNA(A498-hspa7-siRNA), a control siRNA (A498-siRNA-NC) or PBS(A498-WT); ORCS2 cells were transfected with a HSPA7-specific vector (ORSC2-hspa7-OE), a control vector(ORSC2- vector) or PBS(ORCS2-WT). (
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PMC11770130
But Ntsr2 AKO mice had a higher body weight than control mice when fed by HFD (Fig. 1d).
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PMC11783017
Then, 1 mL of deionized water was added to the mixture, and it was subjected to ultrasonic dispersion to produce the complete Cis/Mn/NH@PGP.
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PMC11549062
The sections were then stained with hematoxylin and eosin (HE) and Masson's trichrome, following standard protocols.
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PMC10158546
We detected residual inoculum within the ReN cell cultures for as long as 6 weeks post-exposure (Figure 7), illustrating a major challenge of prion research – distinguishing de novo prion replication from PrP present within the inoculum.
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PMC11740207
Key transcription factors such as T-box transcription factor T (TBXT), Mesoderm posterior protein 1 (MESP1), and Transcription factor GATA-4 are upregulated during mesodermal differentiation (Vacanti et al., 2001), orchestrating the transition of pluripotent cells into mesodermal progenitors that can give rise to muscle, bone, and cardiovascular system.
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PMC10976516
Nonetheless, some of the complement protein effects can be antagonized by intrinsic factors encoded by specific OVs, such as glycoprotein C of herpes simplex virus (HSV) and complement control protein VCP encoded by vaccinia virus (VV).
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PMC6133382
Samples were shielded from light and incubated on ice with GNA for 30 minutes.
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PMC8481254
In addition, we detected the expression of Nudt9 and SLC5A3, which are involved in HBP and are modulated by YAP .
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PMC11786704
Heatmap of DEGs in diabetic mouse models. (
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PMC11351758
We also discovered that mitochondrial calcium overload leads to the depletion of CL, which is an important component of the cell ultrastructure to maintain integrity .
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PMC6948907
The cells were cultured in 24-well culture plates and divided into different experimental groups after 24 h. Two groups received a single dose of GE at the concentration of 25 μM, two groups received a single dose of VPA at the concentration of 5μM, two groups received GE (25μM, IC50) combined with VPA (5μM, IC50) for 24 and 48 h respectively.
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PMC10545062
Analog data was collated by a microcontroller and converted to a digital signal, which was passed to the PACC-MAN platform with graphical user interface running on a separate computer.
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PMC9429973
Treatment with midostaurin, the first orally multikinase/KIT inhibitor approved for AdvSM in both the United States and the European Union in 2017, resulted in a relevant clinical activity with an acceptable safety profile as demonstrated by two single-arm trials (Gotlib 2016, DeAngelo 2018).
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PMC11754436
CAPZA1 (Fig. 4A) and PDCD4 (Fig. 4D) showed no difference in prognostic effects.
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PMC10376064
The homogenized suspension was ultracentrifuged (40,000× g, 10 min, 4 °C).
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PMC9325715
Moreover, water molecules are indispensable part of such kind of interactions and should not be omitted in molecular docking analysis as it can change dramatically the final result.
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PMC8193046
Prospective ligand-based design is more preferred, as it does not rely on crystal structures, cryo-EM structures, or homology models of ABC transporters.
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PMC11518702
Our laboratory additionally discovered C1ORF186/RHEX as a novel EPOR/JAK2-pY-modulated plasma membrane adaptor that also has been shown to be highly abundant in primary human mast cells (21).
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PMC11575040
The Mann–Whitney U tests and the Kruskal–Wallis one-way ANOVA tests were employed to evaluate the correlations of lncRNA expression in melanoma tissues, adjacent normal tissues, and normal control tissues (nevi) with clinicopathological parameters.
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PMC11774747
Blocking experiments with monoclonal antibodies against the CAR-targeted antigen confirmed the specificity of the CAR-mediated killing (81, 82, 96).
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PMC11637276
A deep comprehension of how cancer cells interact with the ECM is essential to understand tumour growth and metastasis.
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PMC11518702
Additionally, increases in HGAL due to PRDM1 mutation may drive DLBCL.
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PMC11629192
Wenxiao Wu: Resources, Project administration, Methodology, Investigation, Formal analysis.
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PMC11695623
Univariate and multivariate Cox analysis were used to screen potential prognostic factors.
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PMC11347429
Gene HP had the lowest significance for a cis-eQTL and did not show a clear separation.
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PMC11522251
Using 4% paraformaldehyde, the cells were fixed for 10 min, and then the colonies were stained with 0.1% crystal violet at ambient temperature for 20 min.
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PMC5415764
After washing the cells three times with cold PBS, the fluorescence intensity was detected using a flow cytometer (FCM, BD Biosciences, California, USA) at an emission wavelength of 525 nm and an excitation wavelength of 488 nm.
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PMC11726848
In both irradiation modes, we observed the presence of DNA damage in the form of strand breaks.
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PMC11519567
Processing duration was recorded, and the condensate state was observed.
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PMC11155445
In the control negative group the production of cytokines was zero while in the positive control group production of cytokines was of high values, for example maximum production of different cytokines are TNFα, IL 6, IL12p40 and GM-CSF 7800, 5500, 6500 and 800, respectively.
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PMC9429973
In univariate analyses, shorter PFS was associated (p<0.05) with lack of response to the latest therapy, longer indication-to-CAR intervals, higher ECOG, stage III/IV disease, IPI, extranodal disease (END), higher LDH, ferritin, CRP levels, and Tisa-cel use.
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PMC11046454
As imaged with confocal laser scanning microscopy (CLSM), a significant Cy5 fluorescence was observed on the membrane of CAR-J after treatment with FITC-DNA-Cy5 (Figures 1B and S4).
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PMC8740518
During chronic inflammation, pro-inflammatory metabolites are upregulated to create an ideal environment for tumour growth (Rayburn, Ezell & Zhang, 2009).
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