PMCID
string | Sentences
string | ner
list |
|---|---|---|
PMC9429973
|
There continue to be though few therapeutic options after relapse.
|
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"therapeutic",
"options",
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"."
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}
] |
PMC11467964
|
Both univariate and multivariate Cox regression exhibited that risk scores were markedly related to STS prognosis.
|
[
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"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
"O"
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"that",
"risk",
"scores",
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"markedly",
"related",
"to",
"STS",
"prognosis",
"."
]
}
] |
PMC11774747
|
Moreover, the expansion of CAR-VST after transduction, skew their maturation of T cell subsets.
|
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
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"O",
"O",
"O",
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"cell",
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]
}
] |
PMC11754094
|
After 24 h, the cells were exposed to M4344 (1 nM, 5 nM, 10 nM, 25 nM and 50 nM) for 1 h after which 750 ng of Cas9 and 250 ng of sgRNA expression plasmids were transfected with 2 μl of lipofectamine 2000 reagent (Invitrogen) into HeLa cells.
|
[
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"Invitrogen",
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"."
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}
] |
PMC9024365
|
Plates were transferred back to 37C incubator for 30 min.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"back",
"to",
"37C",
"incubator",
"for",
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"min",
"."
]
}
] |
PMC11063646
|
7.13) (Dhara et al., 2023).
|
[
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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")",
"(",
"Dhara",
"et",
"al.",
",",
"2023",
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"."
]
}
] |
PMC11763111
|
Among these modifications, HLA-I knockdown had the most significant effect on reducing alloreactivity.
|
[
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O"
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",",
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"on",
"reducing",
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"."
]
}
] |
PMC11612508
|
The peak observed at 3414.89 cm is attributed to the O–H stretching vibration, which originates from the hydroxyl groups of the water on the NPs.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
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"O",
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"O",
"O",
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"O",
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"O",
"O",
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"."
]
}
] |
PMC9429973
|
The ORR and CR were respectively 79% and 58%.
|
[
{
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"CR",
"were",
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"and",
"58",
"%",
"."
]
}
] |
PMC9926039
|
Some studies have indicated a correlation between low serum soluble TLR4 (TLR4s) and poor survival of early-stage NSCLC patients who received surgical resection.
|
[
{
"tags": [
"O",
"O",
"O",
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"O",
"O",
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"and",
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"survival",
"of",
"early-stage",
"NSCLC",
"patients",
"who",
"received",
"surgical",
"resection",
"."
]
}
] |
PMC9429973
|
Results: A total of 5959 patients were analyzed.
|
[
{
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"Results",
":",
"A",
"total",
"of",
"5959",
"patients",
"were",
"analyzed",
"."
]
}
] |
PMC9917080
|
We believe that sorafenib in the free form can only be present in trace amounts.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"be",
"present",
"in",
"trace",
"amounts",
"."
]
}
] |
PMC11770199
|
p14 gene was inserted into pCW57 vector with 7× tet operator and expressing rTetR protein. (
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
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"and",
"expressing",
"rTetR",
"protein",
".",
"("
]
}
] |
PMC9429973
|
CR/CRi was obtained in 43% (32/74) patients after first cycle with CPX-351.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"%",
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"32/74",
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"patients",
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"cycle",
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"."
]
}
] |
PMC11401358
|
The fluorophore concentration was 0.5 μM for ThT. The concentration of SF was diluted to 0.5 mg/mL, and the concentration of polypeptide was diluted to 1 mg/mL. CD spectra were recorded from 190 to 260 nm using a spectrometer (J-1500-150, JASCO, Tokyo, Japan).
|
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"O",
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"O",
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"J-1500",
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"150",
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"Tokyo",
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]
}
] |
PMC11788920
|
The DNA and RNA were harvested via the crush and soak method by tumbling the gel slice overnight at 4°C in a solution of 300 mM NaCl, 10 mM Tris–HCl, and 0.1 mM EDTA (pH 7.4).
|
[
{
"tags": [
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"pH",
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}
] |
PMC10329074
|
The effect of YBX3 knockdown on the proliferation of A498 cell line was examined by a CCK-8 proliferation assay and a clone formation assay.
|
[
{
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"proliferation",
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"and",
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"clone",
"formation",
"assay",
"."
]
}
] |
PMC11349530
|
Some substances that have demonstrated potent antitumor effects in vivo have been observed to inhibit the production of various cytokines by tumor cells (for example, the polyphenolic metabolite of the intestinal microbiota urolithin A) (76, 97, 98).
|
[
{
"tags": [
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"A",
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"76",
",",
"97",
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"98",
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]
}
] |
PMC11201245
|
The aim of this work is to find areas with the most common chromosomal changes in ovarian cancers and then generate a FISH probe homologous to these areas.
|
[
{
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"O",
"O",
"O",
"O",
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"generate",
"a",
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"probe",
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"to",
"these",
"areas",
"."
]
}
] |
PMC9429973
|
Aims: We aimed to evaluate clinical and patient-reported outcomes during IRd treatment as ≥ 2nd line in RRMM patients in a multicenter real-world evidence study.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
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"≥",
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"line",
"in",
"RRMM",
"patients",
"in",
"a",
"multicenter",
"real-world",
"evidence",
"study",
"."
]
}
] |
PMC11240571
|
The isolated cells were cultivated and expanded into a Petri dish to reach 80% confluence.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"The",
"isolated",
"cells",
"were",
"cultivated",
"and",
"expanded",
"into",
"a",
"Petri",
"dish",
"to",
"reach",
"80",
"%",
"confluence",
"."
]
}
] |
PMC11583010
|
B, Comparative HIC profile between the naked humanized 15A7.5 and ETx-22.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"B",
",",
"Comparative",
"HIC",
"profile",
"between",
"the",
"naked",
"humanized",
"15A7.5",
"and",
"ETx-22",
"."
]
}
] |
PMC11680391
|
All through the limitations, this study fills a gap in the current literature and has contributed new knowledge to help improve the quality of udder health consulting.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
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"knowledge",
"to",
"help",
"improve",
"the",
"quality",
"of",
"udder",
"health",
"consulting",
"."
]
}
] |
PMC11265931
|
The plant group or species preferred in the use of these resources allow different diseases and applications according to the content they have (Horibe et al., 2018).
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"tokens": [
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"group",
"or",
"species",
"preferred",
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"allow",
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"and",
"applications",
"according",
"to",
"the",
"content",
"they",
"have",
"(",
"Horibe",
"et",
"al.",
",",
"2018",
")",
"."
]
}
] |
PMC11599565
|
To study a possible interference of Notch signaling with the observed “axonal or dendritic arborization” in induced neuronal-like OC cells, we exposed SKOV3 cells to two γ-secretase inhibitors (GSIs), both indirect inhibitors of this cascade RG-4733 (1 µM, also known as RO4929097) and DAPT (5 µM), purchased from MedChemExpress (NJ, USA).
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-CellLine",
"O",
"O",
"O",
"O",
"B-CellLine",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
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"O",
"O",
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"O",
"O",
"O"
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PMC9429973
|
Of the 9 pts infused, median age of 65 years (range: 41-71) and a median of 6 (range 3-17) prior lines of therapy; 4 (44.4%) prior BCMA CART therapy.
|
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PMC10667689
|
Ctrl, control group; FFA, free fatty acid; PMA, phorbol 12-myristate 13-acetate.
|
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PMC10745221
|
For immunoblotting, gels were transferred onto a PVDF membrane with transfer buffer (10% (v/v) Tris-glycine, 10% (v/v) methanol) at 30V for 2 hours with ice using a BioRad PowerPac 300 electrophoresis Power supply.
|
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PMC4685341
|
Furthermore, a high throughput RT-qPCR method was developed based on the RealTime ready technology to monitor gene transcription based on CHO cells that was not previously available.
|
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PMC11757230
|
The bioluminescence signal is depicted as pseudocolor (red = intense, blue = less intense), and the color scale indicates luminescence intensity per pixel.
|
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PMC7192625
|
This finding might suggest modulated expression levels of the genes across individuals depending on the presence of the H3K27ac activation mark on the corresponding enhancers.
|
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PMC7709199
|
However, crystallogenesis can be hampered by the extent and heterogeneity of N-glycans.
|
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PMC9622879
|
With the rapid increase in many distributed energy resources (DERs), such as renewable energy systems (RESs) and energy storage systems (ESSs) at many smart homes, community energy management systems (CEMSs) for local energy communities (LECs) to reduce the energy cost of this group and increase the benefit for each member have received substantial research attention.
|
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PMC9429973
|
OS was 92%.
|
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"O",
"O",
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"%",
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}
] |
PMC11763126
|
Incubate cell lysates with the bead-peptide complex at overnight.
|
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PMC11683240
|
D and E, PT (10 ng/ml) and different concentrations of α1AT or the respective amount of solvent (H2O) were preincubated for 15 min at room temperature and added to CHO-K1 cells in FCS-free medium for 4 h at 37 °C.
|
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PMC11634027
|
ds wings were on average 12% smaller than control wings (Fig. 1F,O), whereas ds and ds wings were on average 5% and 11%, respectively, larger than control wings (Fig. 1H,I,O).
|
[
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PMC8751435
|
Briefly, A549 cells were treated with CME (1, 10, 100, and 200 μg/ml) for 24 h. Protein from cell lysates was measured using the BCA assay, separated by electrophoresis, and transferred onto polyvinylidene fluoride (PVDF) membrane (0.45 μm; EMD Millipore).
|
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PMC11467964
|
Finally, in vitro experiments showed significantly differential expression levels of these signature genes in STS cells and PSAT1 could promote the malignant behavior of STS.
|
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}
] |
PMC10809689
|
Some clinical trials have shown that TIM-3 blockade alone fails to achieve clinical efficacy for most patients with AML or MDS and improvement in clinical outcome is only observed when TIM-3 is combined with other checkpoint inhibitors, such as tyrosine kinase inhibitors (TKIs) or hypomethylating agents (HMA) [11–13].
|
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}
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PMC7090062
|
c The beclin-1 expression level in GIST cells was assayed by western blot. ***
|
[
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"O",
"O",
"O",
"O",
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"O",
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}
] |
PMC2777936
|
Primer sequences used for real-time RT-PCR assays appear in additional file 1.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
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"O",
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"appear",
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"file",
"1",
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]
}
] |
PMC5811757
|
Total RNA was obtained using the RNX-Plus (SinaClon Co Iran) kit.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
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"kit",
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}
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PMC9429973
|
The proportion of participants with systemic AEs and serious AEs after any dose of study vaccine were generally comparable between intervention groups in the pediatric and adult cohorts.
|
[
{
"tags": [
"O",
"O",
"O",
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PMC11706776
|
These EWS::FLI1/EWS::ERG binding sites contain at least 12 GGAA microsatellites repetitions, indicated by the red vertical lines (Fig. 3A–D and Supplementary Fig. 4A).Fig.
|
[
{
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"sites",
"contain",
"at",
"least",
"12",
"GGAA",
"microsatellites",
"repetitions",
",",
"indicated",
"by",
"the",
"red",
"vertical",
"lines",
"(",
"Fig.",
"3A",
"–",
"D",
"and",
"Supplementary",
"Fig.",
"4A).Fig",
"."
]
}
] |
PMC11755624
|
NPM is upregulated in psoriasis.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"NPM",
"is",
"upregulated",
"in",
"psoriasis",
"."
]
}
] |
PMC9429973
|
Both short (5 days) and long-term (up to 28 days) assays were performed to explore the effects of drug treatment on the AML growth and cell renewal capacity.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
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"short",
"(",
"5",
"days",
")",
"and",
"long-term",
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"up",
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"28",
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"assays",
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"to",
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"effects",
"of",
"drug",
"treatment",
"on",
"the",
"AML",
"growth",
"and",
"cell",
"renewal",
"capacity",
"."
]
}
] |
PMC7812570
|
More importantly, GPI-m36.4-modified human CD4+ cells (CEMss-CCR5) were exceptionally resistant to both CCR5- and CXCR4-tropic HIV-1 isolates and had a robust selective survival advantage over unmodified cells following HIV-1 infection.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-CellLine",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"More",
"importantly",
",",
"GPI-m36.4-modified",
"human",
"CD4",
"+",
"cells",
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"CEMss-CCR5",
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"were",
"exceptionally",
"resistant",
"to",
"both",
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"CXCR4-tropic",
"HIV-1",
"isolates",
"and",
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"a",
"robust",
"selective",
"survival",
"advantage",
"over",
"unmodified",
"cells",
"following",
"HIV-1",
"infection",
"."
]
}
] |
PMC11683240
|
To identify PT-inhibitory peptides/proteins, we generated peptide/protein library derived from human hemofiltrate and screened it for inhibitors of PT function.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"identify",
"PT-inhibitory",
"peptides/proteins",
",",
"we",
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"peptide/protein",
"library",
"derived",
"from",
"human",
"hemofiltrate",
"and",
"screened",
"it",
"for",
"inhibitors",
"of",
"PT",
"function",
"."
]
}
] |
PMC11001582
|
Mice were trained the week before starting the test.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Mice",
"were",
"trained",
"the",
"week",
"before",
"starting",
"the",
"test",
"."
]
}
] |
PMC10743717
|
it is certainly not so in the reduction of S-acetoacetyl-CoA by NADH, because the Vmax of 17β-HSD10/SCHAD for catalyzing this hydrogenation reaction of S-acetoacetyl-CoA is much greater than that for its catalyzing of 17β-estradiol oxidation by about thirty-three hundred folds .
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"tokens": [
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"catalyzing",
"of",
"17β-estradiol",
"oxidation",
"by",
"about",
"thirty-three",
"hundred",
"folds",
"."
]
}
] |
PMC11451940
|
The precipitate obtained was collected by filtration, washed with deionised water (3 × 10 mL), methanol (3 × 10 mL), and Et2O (3 × 10 mL), and dried under vacuum.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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",",
"washed",
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"3",
"×",
"10",
"mL",
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",",
"methanol",
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"3",
"×",
"10",
"mL",
")",
",",
"and",
"Et2O",
"(",
"3",
"×",
"10",
"mL",
")",
",",
"and",
"dried",
"under",
"vacuum",
"."
]
}
] |
PMC11261875
|
GIST primarily develops due to the constitutive activation of the receptor tyrosine kinase KIT or PDGFRA, with approximately 75 % of GISTs harboring gain-of-function mutations in KIT .
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"tokens": [
"GIST",
"primarily",
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"due",
"to",
"the",
"constitutive",
"activation",
"of",
"the",
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"kinase",
"KIT",
"or",
"PDGFRA",
",",
"with",
"approximately",
"75",
"%",
"of",
"GISTs",
"harboring",
"gain-of-function",
"mutations",
"in",
"KIT",
"."
]
}
] |
PMC11762280
|
N-GSDMD N-terminal GSDMD.
|
[
{
"tags": [
"O",
"O",
"O",
"O"
],
"tokens": [
"N-GSDMD",
"N-terminal",
"GSDMD",
"."
]
}
] |
PMC11365983
|
The first demonstrated that ablating cilia by conditional Ift88 deletion induced ocular mal-development characteristic of ARS: findings reiterated by a second that targeted Ift46.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"The",
"first",
"demonstrated",
"that",
"ablating",
"cilia",
"by",
"conditional",
"Ift88",
"deletion",
"induced",
"ocular",
"mal-development",
"characteristic",
"of",
"ARS",
":",
"findings",
"reiterated",
"by",
"a",
"second",
"that",
"targeted",
"Ift46",
"."
]
}
] |
PMC11078693
|
The Spinning Disk pinholes size was 50 μm.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"The",
"Spinning",
"Disk",
"pinholes",
"size",
"was",
"50",
"μm",
"."
]
}
] |
PMC11711127
|
A higher ratio of inhibitory to co-stimulatory receptors (e.g high PD-1 and CTLA-4) is also expected, as well as a similar imbalance towards soluble inhibitors such as indoleamine-pyrrole 2,3-dioxygenase and IL-10 (109).
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"A",
"higher",
"ratio",
"of",
"inhibitory",
"to",
"co-stimulatory",
"receptors",
"(",
"e.g",
"high",
"PD-1",
"and",
"CTLA-4",
")",
"is",
"also",
"expected",
",",
"as",
"well",
"as",
"a",
"similar",
"imbalance",
"towards",
"soluble",
"inhibitors",
"such",
"as",
"indoleamine-pyrrole",
"2,3-dioxygenase",
"and",
"IL-10",
"(",
"109",
")",
"."
]
}
] |
PMC10748106
|
Therefore, we obtained the dimensional components of the dipole vector of these simple iridoids.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Therefore",
",",
"we",
"obtained",
"the",
"dimensional",
"components",
"of",
"the",
"dipole",
"vector",
"of",
"these",
"simple",
"iridoids",
"."
]
}
] |
PMC11040965
|
These results suggest that variations in miR29b and DNMT3B levels parallel tumor progression, as revealed by tumor plasma cell burden.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"These",
"results",
"suggest",
"that",
"variations",
"in",
"miR29b",
"and",
"DNMT3B",
"levels",
"parallel",
"tumor",
"progression",
",",
"as",
"revealed",
"by",
"tumor",
"plasma",
"cell",
"burden",
"."
]
}
] |
PMC9429973
|
Even though in some studies bendamustine has shown to be less toxic and more effective than CHOP in FL, there are some important pandemic aspects that must be considered.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Even",
"though",
"in",
"some",
"studies",
"bendamustine",
"has",
"shown",
"to",
"be",
"less",
"toxic",
"and",
"more",
"effective",
"than",
"CHOP",
"in",
"FL",
",",
"there",
"are",
"some",
"important",
"pandemic",
"aspects",
"that",
"must",
"be",
"considered",
"."
]
}
] |
PMC9429973
|
Aims: We aim to evaluate the efficacy, safety, and quality of life of PMBL patients treated in the PACIFIC trial with BV and Nivolumab alone and then combined with Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP).
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Aims",
":",
"We",
"aim",
"to",
"evaluate",
"the",
"efficacy",
",",
"safety",
",",
"and",
"quality",
"of",
"life",
"of",
"PMBL",
"patients",
"treated",
"in",
"the",
"PACIFIC",
"trial",
"with",
"BV",
"and",
"Nivolumab",
"alone",
"and",
"then",
"combined",
"with",
"Rituximab",
",",
"Cyclophosphamide",
",",
"Doxorubicin",
",",
"and",
"Prednisone",
"(",
"R-CHP",
")",
"."
]
}
] |
PMC10900886
|
Gating strategies to define different cell phenotypes and to define VP1 cells are presented in Fig. 7.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Gating",
"strategies",
"to",
"define",
"different",
"cell",
"phenotypes",
"and",
"to",
"define",
"VP1",
"cells",
"are",
"presented",
"in",
"Fig.",
"7",
"."
]
}
] |
PMC11770130
|
Western blotting was conducted using various specific primary and secondary antibodies.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Western",
"blotting",
"was",
"conducted",
"using",
"various",
"specific",
"primary",
"and",
"secondary",
"antibodies",
"."
]
}
] |
PMC8777939
|
Finally, the migrating cells were counted using a Lion Heart FX automated microscope (Biotek, Winooski, VT, USA).
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Finally",
",",
"the",
"migrating",
"cells",
"were",
"counted",
"using",
"a",
"Lion",
"Heart",
"FX",
"automated",
"microscope",
"(",
"Biotek",
",",
"Winooski",
",",
"VT",
",",
"USA",
")",
"."
]
}
] |
PMC8382973
|
In addition, we demonstrated that the 2P23 gel was stable and fully functional at pH 4.0–8.0 and under different concentrations of H2O2.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"In",
"addition",
",",
"we",
"demonstrated",
"that",
"the",
"2P23",
"gel",
"was",
"stable",
"and",
"fully",
"functional",
"at",
"pH",
"4.0–8.0",
"and",
"under",
"different",
"concentrations",
"of",
"H2O2",
"."
]
}
] |
PMC9429973
|
We also performed in vitro activity assays against primary non-Hodgkin Lymphoma cells expressing different levels of the targeted antigens.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"We",
"also",
"performed",
"in",
"vitro",
"activity",
"assays",
"against",
"primary",
"non-Hodgkin",
"Lymphoma",
"cells",
"expressing",
"different",
"levels",
"of",
"the",
"targeted",
"antigens",
"."
]
}
] |
PMC11792766
|
No. 10107409001), colchicine (Carl Roth, Cat.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"No.",
"10107409001",
")",
",",
"colchicine",
"(",
"Carl",
"Roth",
",",
"Cat",
"."
]
}
] |
PMC6461034
|
INKA score ranking of the top 20 active phosphokinases in two PDX models (metastatic colorectal cancer, CRC0177 and CRC0254) indicates high activity of receptor tyrosine kinases IGF1R/INSR, EGFR, ERBB2, EPHA1/2, EPHB1‐4, and MET.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"INKA",
"score",
"ranking",
"of",
"the",
"top",
"20",
"active",
"phosphokinases",
"in",
"two",
"PDX",
"models",
"(",
"metastatic",
"colorectal",
"cancer",
",",
"CRC0177",
"and",
"CRC0254",
")",
"indicates",
"high",
"activity",
"of",
"receptor",
"tyrosine",
"kinases",
"IGF1R/INSR",
",",
"EGFR",
",",
"ERBB2",
",",
"EPHA1/2",
",",
"EPHB1‐4",
",",
"and",
"MET",
"."
]
}
] |
PMC11724582
|
Furthermore, the secretion of TGF-β1 in H1975 cells also increased with increasing almonertinib concentration.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-CellLine",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Furthermore",
",",
"the",
"secretion",
"of",
"TGF-β1",
"in",
"H1975",
"cells",
"also",
"increased",
"with",
"increasing",
"almonertinib",
"concentration",
"."
]
}
] |
PMC11092382
|
The clinical opiate withdrawal scale (COWS) was used to assess withdrawal symptoms.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"The",
"clinical",
"opiate",
"withdrawal",
"scale",
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"COWS",
")",
"was",
"used",
"to",
"assess",
"withdrawal",
"symptoms",
"."
]
}
] |
PMC11720808
|
The chemical structure of scutellarein. (
|
[
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"scutellarein",
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]
}
] |
PMC11763764
|
These trials in unselected ovarian cancer patients only achieved a 0–6% response rate in patients with persistent or recurrent tumors and did not show survival benefit as a maintenance treatment for patients with stable disease after first-line chemotherapy .
|
[
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}
] |
PMC11673902
|
To reduce the variability between measurements, they used a histogram matching of pressure, strain, and protein expression levels, which selects and analyzes only those cells that have experienced the same pressure and strain, effectively improving the repeatability of measurements.
|
[
{
"tags": [
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}
] |
PMC11470381
|
xbl2=Xc[j]widthPxl-Major[j]/2widthPxl*cos(θ) ybl2=Yc[j]heightPxl+Major[j]/2heightPxl*sin(θ) widthPxl and heightPxl = width (along x-axis) and height (along y-axis) of the ROI.
|
[
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] |
PMC11335267
|
Rbfox3, Esrrg and Gfar1 are selective markers of motor neurons (n = 4). (
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"n",
"=",
"4",
")",
".",
"("
]
}
] |
PMC11746942
|
The genotyping primers used were listed in Supplementary Table S1.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"The",
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"primers",
"used",
"were",
"listed",
"in",
"Supplementary",
"Table",
"S1",
"."
]
}
] |
PMC9429973
|
Median PFS and OS has not been reached.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"Median",
"PFS",
"and",
"OS",
"has",
"not",
"been",
"reached",
"."
]
}
] |
PMC7823217
|
This model showed chemotherapeutic drug resistance commonly seen in HCC patients.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"This",
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"showed",
"chemotherapeutic",
"drug",
"resistance",
"commonly",
"seen",
"in",
"HCC",
"patients",
"."
]
}
] |
PMC10900886
|
Together, the results suggested that imDCs might be capable to transmit virus to other susceptible immune cells, such as B cells, which subsequently become productively infected.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"cells",
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"which",
"subsequently",
"become",
"productively",
"infected",
"."
]
}
] |
PMC5173112
|
However, the effects and underlying mechanism of USP21 on renal cell carcinomas (RCC) remain unclear.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"mechanism",
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"cell",
"carcinomas",
"(",
"RCC",
")",
"remain",
"unclear",
"."
]
}
] |
PMC11342785
|
F, example epifluorescence images of microtubule architectures driven by synMAP TPPP-IDR condensates that differ in the identity of the condensate-forming IDR sequence.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"F",
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"condensates",
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"differ",
"in",
"the",
"identity",
"of",
"the",
"condensate-forming",
"IDR",
"sequence",
"."
]
}
] |
PMC6487404
|
A relatively high apparent permeability coefficient for the apical to basolateral REG transport (1.84 × 10± 0.12 cm/s at 40 µM drug concentration) suggests that the drug can be effectively absorbed in the intestinal tract.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"tokens": [
"A",
"relatively",
"high",
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"1.84",
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"can",
"be",
"effectively",
"absorbed",
"in",
"the",
"intestinal",
"tract",
"."
]
}
] |
PMC11612794
|
Representative data of technical replicates are presented.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Representative",
"data",
"of",
"technical",
"replicates",
"are",
"presented",
"."
]
}
] |
PMC10507284
|
Based on the above research reports, we found that the Wnt signaling pathway is an important downstream signaling pathway of TROAP, hinting that TROAP might regulate this signaling pathway to affect the malignant biological behavior and cell cycle of STS cells.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
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"of",
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"hinting",
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"this",
"signaling",
"pathway",
"to",
"affect",
"the",
"malignant",
"biological",
"behavior",
"and",
"cell",
"cycle",
"of",
"STS",
"cells",
"."
]
}
] |
PMC11746948
|
In GPX4-knockout A375 cells, re-expression of GPX4-WT, GPX4-C66S, and GPX4-C75S mutants maintained cell viability in the absence of Fer-1.
|
[
{
"tags": [
"O",
"O",
"B-CellLine",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"In",
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"mutants",
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"cell",
"viability",
"in",
"the",
"absence",
"of",
"Fer-1",
"."
]
}
] |
PMC11792090
|
Cytotoxicity of mock CAR-T cells and UCAR-T cells against 786-0 cells at the indicated E:T ratios. (
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-CellLine",
"I-CellLine",
"I-CellLine",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Cytotoxicity",
"of",
"mock",
"CAR-T",
"cells",
"and",
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"cells",
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"0",
"cells",
"at",
"the",
"indicated",
"E",
":",
"T",
"ratios",
".",
"("
]
}
] |
PMC8345486
|
Nonetheless, compound 25, unlike compound 23, did not affect apoptosis or cell viability.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Nonetheless",
",",
"compound",
"25",
",",
"unlike",
"compound",
"23",
",",
"did",
"not",
"affect",
"apoptosis",
"or",
"cell",
"viability",
"."
]
}
] |
PMC9261184
|
During loading and unloading, a small amount of venting occurred to connecting/disconnecting the loading arms prior to LNG transfer.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"During",
"loading",
"and",
"unloading",
",",
"a",
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"amount",
"of",
"venting",
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"to",
"connecting/disconnecting",
"the",
"loading",
"arms",
"prior",
"to",
"LNG",
"transfer",
"."
]
}
] |
PMC11389534
|
If so, what are the underlying molecular mechanisms, and could they be used in cancer immunotherapy as potential targets?
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"If",
"so",
",",
"what",
"are",
"the",
"underlying",
"molecular",
"mechanisms",
",",
"and",
"could",
"they",
"be",
"used",
"in",
"cancer",
"immunotherapy",
"as",
"potential",
"targets",
"?"
]
}
] |
PMC7823217
|
Therefore, there is an unmet clinical need for the development of better diagnostic and treatment strategies.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Therefore",
",",
"there",
"is",
"an",
"unmet",
"clinical",
"need",
"for",
"the",
"development",
"of",
"better",
"diagnostic",
"and",
"treatment",
"strategies",
"."
]
}
] |
PMC11128598
|
Improvements in the conventional treatments, which include surgery, radiation therapy, and chemotherapy together with new approaches, such as immune-mediated therapies or targeted therapy are increasing survival rates of this devastating disease.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Improvements",
"in",
"the",
"conventional",
"treatments",
",",
"which",
"include",
"surgery",
",",
"radiation",
"therapy",
",",
"and",
"chemotherapy",
"together",
"with",
"new",
"approaches",
",",
"such",
"as",
"immune-mediated",
"therapies",
"or",
"targeted",
"therapy",
"are",
"increasing",
"survival",
"rates",
"of",
"this",
"devastating",
"disease",
"."
]
}
] |
PMC9429973
|
MOLM-13-NRAS-Q61K over-expression cells showed a growth advantage compared to parental cells in normal culture.
|
[
{
"tags": [
"B-CellLine",
"I-CellLine",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"MOLM-13-NRAS-Q61",
"K",
"over-expression",
"cells",
"showed",
"a",
"growth",
"advantage",
"compared",
"to",
"parental",
"cells",
"in",
"normal",
"culture",
"."
]
}
] |
PMC11462673
|
Additionally, our analysis of transcriptomic data from T-ALL patients at our center reveals a correlation between the expression levels of core hematopoietic transcription factors (ERG, ETV6, ETS1, RUNX1, IRF1, and MYB) and LDB1, providing further clinical validation of potential interactions among transcription factor complexes.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Additionally",
",",
"our",
"analysis",
"of",
"transcriptomic",
"data",
"from",
"T-ALL",
"patients",
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"center",
"reveals",
"a",
"correlation",
"between",
"the",
"expression",
"levels",
"of",
"core",
"hematopoietic",
"transcription",
"factors",
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"ERG",
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"ETV6",
",",
"ETS1",
",",
"RUNX1",
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"IRF1",
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"MYB",
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"and",
"LDB1",
",",
"providing",
"further",
"clinical",
"validation",
"of",
"potential",
"interactions",
"among",
"transcription",
"factor",
"complexes",
"."
]
}
] |
PMC9509578
|
Chow et al. showed that nanodiamonds are an ideal drug delivery system that offers biocompatibility, drug conjugation, controlled release and enhanced aqueous dispersion properties.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Chow",
"et",
"al.",
"showed",
"that",
"nanodiamonds",
"are",
"an",
"ideal",
"drug",
"delivery",
"system",
"that",
"offers",
"biocompatibility",
",",
"drug",
"conjugation",
",",
"controlled",
"release",
"and",
"enhanced",
"aqueous",
"dispersion",
"properties",
"."
]
}
] |
PMC5261804
|
Project Achilles currently provides a pooled shRNA screening database with more than 11,000 genes in 216 cell lines .
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
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] |
PMC9429973
|
Aims: The aim of our study was to analyse the characteristics of non-clonal erythrocytosis in patients referred to our Haematology department in a 5-year period (2016 – 2021) and to compare the IE group to the group with known causes.
|
[
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PMC11496491
|
7GO enrichment analysis results show the top 10 Term analysis charts that are most significant in terms of molecular function. (
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
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PMC11760643
|
Analysis of T cell subsets showed that numbers of CD3 (p = 0.94; Figure 4A), CD4 (p = 0.81; Figure 4B), and CD8 T cells (p = 0.99; Figure 4C), CD4CD8 (p = 0.78; Figure 4D), and CD4CD8 T cells (p = 0.85; Figure 4E), Tcons (p = 0.81) (Figure 4F), Tregs (p ≥ 0.99; Figure 4G) and CD39 Tregs (p = 0.61; Figure 4H) were comparable between treatments with minimal percent change.
|
[
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"O",
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"O",
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PMC8557138
|
However, the authors also observed that the vascular spouts regressed after 8 days of culture (Aplin and Nicosia 2016).
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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}
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PMC11754291
|
Fibroblasts are known to secrete factors that can influence melanogenesis, but their contribution to α-MSH production is negligible compared to keratinocytes (Russo et al., 2020).
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"Russo",
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",",
"2020",
")",
"."
]
}
] |
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