Datasets:
Brizape
/
amia_split_0404

Dataset card Data Studio Files
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20725929
[ "The", "MUTYH", " ", "gene", "encodes", "a", "DNA", "glycosylase", "involved", "in", "base", "excision", "repair", "(BER).", "Biallelic", "pathogenic", "MUTYH", "DNA", "glycosylase", " ", "involved", "in", "base", "excision", "repair", "(BER).", "Biallelic", "pa...
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The MUTYH gene encodes a DNA glycosylase involved in base excision repair (BER). Biallelic pathogenic MUTYH DNA glycosylase involved in base excision repair (BER). Biallelic pathogenic MUTYH variants have been associated with colorectal polyposis and cancer. The pathogenicity of a few variants is beyond doubt, incl...
20725929
[]
[]
16885347
[ "MLH3", "mutation", "in", "endometrial", "cancer." ]
[ 0, 0, 0, 0, 0 ]
MLH3 mutation in endometrial cancer.
16885347
[ "MLH3", "is", "a", "recently", "described", "member", "of", "the", "DNA", "mismatch", "repair", "gene", "family.", "Based", "on", "its", "interaction", "with", "the", "MutL", "homologue", "MLH1,", "it", "was", "postulated", "that", "MLH3", "might", "play", "...
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MLH3 is a recently described member of the DNA mismatch repair gene family. Based on its interaction with the MutL homologue MLH1, it was postulated that MLH3 might play a role in tumorigenesis. Germ line and somatic mutations in MLH3 have been identified in a small fraction of colorectal cancers, but the role of MLH3 ...
16885347
[ "MLH3", " ", "is", "a", "recently", "described", "member", "of", "the", "DNA", "mismatch", "repair", "gene", "family.", "Based", "on", "its", "interaction", "with", "the", "MutL", "homologue", "MLH1", "MutL", "homologue", " ", "MLH1,", "it", "was", "postulat...
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MLH3 is a recently described member of the DNA mismatch repair gene family. Based on its interaction with the MutL homologue MLH1 MutL homologue MLH1, it was postulated that MLH3 might play a role in tumorigenesis. Germ line and somatic mutations in MLH3 mutations in MLH3 have been identified in a small fractio...
16885347
[]
[]
17938238
[ "The", "genetics", "of", "hereditary", "colon", "cancer." ]
[ 0, 0, 0, 0, 0, 0 ]
The genetics of hereditary colon cancer.
17938238
[ "The", "genetic", "basis", "of", "sporadic", "colorectal", "cancer", "has", "illuminated", "our", "knowledge", "of", "human", "cancer", "genetics.", "This", "has", "been", "facilitated", "and", "catalyzed", "by", "an", "appreciation", "and", "deep", "understanding...
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The genetic basis of sporadic colorectal cancer has illuminated our knowledge of human cancer genetics. This has been facilitated and catalyzed by an appreciation and deep understanding of the forms of colorectal cancer that harbor an inherited predisposition, including familial adenomatous polyposis (FAP), hereditary ...
17938238
[]
[]
23259783
[ "Clinical", "impact", "of", "PAI", "1", "4G/5G", "gene", "polymorphism", "in", "colorectal", "carcinoma", "patients." ]
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Clinical impact of PAI 1 4G/5G gene polymorphism in colorectal carcinoma patients.
23259783
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Plasminogen activator ihnibitor (PAI 1) belongs to the plasminogen activator system, which is part of the metastatic cascade and significantly contributes to invasive growth and angiogenesis of malignant tumors. Its plasma level is normally low but 4G/4G homozygotes have higher concentrations of PAI 1. This genotype ma...
23259783
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Plasminogen activator ihnibitor (PAI 1) belongs to the plasminogen activator system, which is part of the metastatic cascade and significantly contributes to invasive growth and angiogenesis of malignant tumors. Its plasma level is normally low but 4G/4G homozygotes have higher concentrations of PAI 1. This genotype ...
23259783
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Plasminogen activator ihnibitor (PAI 1) belongs to the plasminogen activator system, which is part of the metastatic cascade and significantly contributes to invasive growth and angiogenesis of malignant tumors. Its plasma level is normally low but 4G/4G homozygotes have higher concentrations of PAI 1 . This genotype m...
23259783
[]
[]
23096495
[ "Protein", "tyrosine", "phosphatase", "receptor-like", "genes", "are", "frequently", "hypermethylated", "in", "sporadic", "colorectal", "cancer." ]
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Protein tyrosine phosphatase receptor-like genes are frequently hypermethylated in sporadic colorectal cancer.
23096495
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The activity of phosphatases could be influenced by genetic, as well as epigenetic alterations. In our study, we have investigated the methylation status of four PTPRs: PTPRM, PTPRT, PTPRR and PTPRZ1, which were pre-selected using microarray techniques as being alternatively methylated in sporadic colorectal cancer (CR...
23096495
[ "The", "activity", "of", "phosphatases", "could", "be", "influenced", "by", "genetic,", "as", "well", "as", "epigenetic", "alterations.", "In", "our", "study,", "we", "have", "investigated", "the", "methylation", "status", "of", "four", "PTPRs:", "PTPRM,", "PTPR...
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The activity of phosphatases could be influenced by genetic, as well as epigenetic alterations. In our study, we have investigated the methylation status of four PTPRs: PTPRM, PTPRT, PTPRR and PTPRZ1, which were pre-selected using microarray techniques as being alternatively methylated in sporadic colorectal cancer (CR...
23096495
[]
[]
22899730
[ "BRAF", "mutation", "status", "and", "survival", "after", "colorectal", "cancer", "diagnosis", "according", "to", "patient", "and", "tumor", "characteristics.", "\n\n\n", "##", "BACKGROUND" ]
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BRAF mutation status and survival after colorectal cancer diagnosis according to patient and tumor characteristics. ## BACKGROUND
22899730
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BRAF mutations in colorectal cancer (CRC) are disproportionately observed in tumors exhibiting microsatellite instability (MSI) and are associated with other prognostic factors. The independent association between BRAF mutation status and CRC survival, however, remains unclear.
22899730
[ "##", "METHODS" ]
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## METHODS
22899730
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We evaluated the association between the BRAF c.1799T>A (p.V600E) mutation and survival in individuals with incident invasive CRC diagnosed between 1997 and 2007 in Western Washington State. Tumor specimens were tested for this BRAF mutation and MSI status. We used Cox regression to estimate HRs and 95% confidence inte...
22899730
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
22899730
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Among 1,980 cases tested, 12% were BRAF c.1799T>A (p.V600E) mutation-positive (n = 247). BRAF -mutated CRC was associated with poorer disease-specific survival adjusting for age, sex, time from diagnosis to enrollment, stage, and MSI status (HR, 1.43; 95% CI, 1.05-1.95). This association was limited to cases diagnose...
22899730
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
22899730
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Our results show that the prevalence of BRAF mutations BRAF mutations in CRC differs by patient and tumor characteristics and suggest that the association between BRAF status and CRC survival may differ by some of these factors.
22899730
[ "##", "IMPACT" ]
[ 0, 0 ]
## IMPACT
22899730
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The presence of a BRAF BRAF BRAF mutation status and survival after colorectal cancer diagnosis according to patient and tumor characteristics. ## BACKGROUND
22899730
[ "BRAF", "mutations", "in", "colorectal", "cancer", "(CRC)", "are", "disproportionately", "observed", "in", "tumors", "exhibiting", "microsatellite", "instability", "(MSI)", "and", "are", "associated", "with", "other", "prognostic", "factors.", "The", "independent", "a...
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BRAF mutations in colorectal cancer (CRC) are disproportionately observed in tumors exhibiting microsatellite instability (MSI) and are associated with other prognostic factors. The independent association between BRAF mutation status and CRC survival, however, remains unclear.
22899730
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
22899730
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We evaluated the association between the BRAF c.1799T>A (p.V600E) mutation and survival in individuals with incident invasive CRC diagnosed between 1997 and 2007 in Western Washington State. Tumor specimens were tested for this BRAF mutation and MSI status. We used Cox regression to estimate HRs and 95% confidence inte...
22899730
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
22899730
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Among 1,980 cases tested, 12% were BRAF c.1799T>A ( p.V600E BRAF mutations in colorectal cancer (CRC) are disproportionately observed in tumors exhibiting microsatellite instability (MSI) and are associated with other prognostic factors. The independent association between BRAF mutation status and CRC survival, howev...
22899730
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
22899730
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We evaluated the association between the BRAF c.1799T>A (p.V600E) mutation and survival in individuals with incident invasive CRC diagnosed between 1997 and 2007 in Western Washington State. Tumor specimens were tested for this BRAF mutation and MSI status. We used Cox regression to estimate HRs and 95% confidence inte...
22899730
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
22899730
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Among 1,980 cases tested, 12% were BRAF c.1799T>A (p.V600E) mutation c.1799T>A microsatellite instability (MSI) and are associated with other prognostic factors. The independent association between BRAF mutation status and CRC survival, however, remains unclear.
22899730
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
22899730
[ "We", "evaluated", "the", "association", "between", "the", "BRAF", "c.1799T>A", "mutations", " ", "in", "colorectal", "cancer", "(CRC)", "are", "disproportionately", "observed", "in", "tumors", "exhibiting", "microsatellite", "instability", "(MSI)", "and", "are", "a...
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We evaluated the association between the BRAF c.1799T>A mutations in colorectal cancer (CRC) are disproportionately observed in tumors exhibiting microsatellite instability (MSI) and are associated with other prognostic factors. The independent association between BRAF mutation status and CRC survival, however, remai...
22899730
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
22899730
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We evaluated the association between the BRAF c.1799T>A (p.V600E) mutation and survival in individuals with incident invasive CRC diagnosed between 1997 and 2007 in Western Washington State. Tumor specimens were tested for this BRAF mutation and MSI status. We used Cox regression to estimate HRs and 95% confidence inte...
22899730
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
22899730
[ "Among", "1,980", "cases", "tested,", "12%", "were", "BRAF", "c.1799T>A", "(p.V600E)", "mutation-positive", "(n", "=", "247).", "BRAF-mutated", "CRC", "was", "associated", "with", "poorer", "disease-specific", "survival", "adjusting", "for", "age,", "sex,", "time", ...
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Among 1,980 cases tested, 12% were BRAF c.1799T>A (p.V600E) mutation-positive (n = 247). BRAF-mutated CRC was associated with poorer disease-specific survival adjusting for age, sex, time from diagnosis to enrollment, stage, and MSI BRAF mutation status and CRC survival, however, remains unclear.
22899730
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
22899730
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We evaluated the association between the BRAF c.1799T>A (p.V600E) mutation and survival in individuals with incident invasive CRC diagnosed between 1997 and 2007 in Western Washington State. Tumor specimens were tested for this BRAF mutation and MSI status. We used Cox regression to estimate HRs and 95% confidence inte...
22899730
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
22899730
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Among 1,980 cases tested, 12% were BRAF c.1799T>A (p.V600E) mutation-positive (n = 247). BRAF-mutated CRC was associated with poorer disease-specific survival adjusting for age, sex, time from diagnosis to enrollment, stage, and MSI status (HR, 1.43; 95% CI, 1.05-1.95). This association was limited to cases diagnosed a...
22899730
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
22899730
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Our results show that the prevalence of BRAF mutations in CRC differs by patient and tumor characteristics and suggest that the association between BRAF status and CRC survival may differ by some of these factors.
22899730
[ "##", "IMPACT" ]
[ 0, 0 ]
## IMPACT
22899730
[ "The", "presence", "of", "a", "BRAF", "c.1799T>A", "MSI", ")", "and", "are", "associated", "with", "other", "prognostic", "factors.", "The", "independent", "association", "between", "BRAF", "mutation", "status", "and", "CRC", "survival,", "however,", "remains", ...
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The presence of a BRAF c.1799T>A MSI ) and are associated with other prognostic factors. The independent association between BRAF mutation status and CRC survival, however, remains unclear.
22899730
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
22899730
[ "We", "evaluated", "the", "association", "between", "the", "BRAF", "c.1799T>A", "(p.V600E)", "mutation", "and", "survival", "in", "individuals", "with", "incident", "invasive", "CRC", "diagnosed", "between", "1997", "and", "2007", "in", "Western", "Washington", "S...
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We evaluated the association between the BRAF c.1799T>A (p.V600E) mutation and survival in individuals with incident invasive CRC diagnosed between 1997 and 2007 in Western Washington State. Tumor specimens were tested for this BRAF mutation and MSI status. We used Cox regression to estimate HRs and 95% confidence inte...
22899730
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
22899730
[ "Among", "1,980", "cases", "tested,", "12%", "were", "BRAF", "c.1799T>A", "(p.V600E)", "mutation-positive", "(n", "=", "247).", "BRAF-mutated", "CRC", "was", "associated", "with", "poorer", "disease-specific", "survival", "adjusting", "for", "age,", "sex,", "time", ...
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Among 1,980 cases tested, 12% were BRAF c.1799T>A (p.V600E) mutation-positive (n = 247). BRAF-mutated CRC was associated with poorer disease-specific survival adjusting for age, sex, time from diagnosis to enrollment, stage, and MSI status (HR, 1.43; 95% CI, 1.05-1.95). This association was limited to cases diagnosed a...
22899730
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
22899730
[ "Our", "results", "show", "that", "the", "prevalence", "of", "BRAF", "mutations", "in", "CRC", "differs", "by", "patient", "and", "tumor", "characteristics", "and", "suggest", "that", "the", "association", "between", "BRAF", "status", "and", "CRC", "survival", ...
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Our results show that the prevalence of BRAF mutations in CRC differs by patient and tumor characteristics and suggest that the association between BRAF status and CRC survival may differ by some of these factors.
22899730
[ "##", "IMPACT" ]
[ 0, 0 ]
## IMPACT
22899730
[ "The", "presence", "of", "a", "BRAF", "c.1799T>A", "(", "p.V600E", "BRAF", " ", "c.1799T>A", "(", "p.V600E", "mutation", " ", "status", "and", "CRC", "survival,", "however,", "remains", "unclear." ]
[ 0, 0, 0, 0, 0, 0, 0, 13, 1, 0, 0, 0, 13, 3, 0, 0, 0, 0, 0, 0, 0, 0 ]
The presence of a BRAF c.1799T>A ( p.V600E BRAF c.1799T>A ( p.V600E mutation status and CRC survival, however, remains unclear.
22899730
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
22899730
[ "We", "evaluated", "the", "association", "between", "the", "BRAF", "c.1799T>A", "(p.V600E)", "mutation", " ", "and", "survival", "in", "individuals", "with", "incident", "invasive", "CRC", "diagnosed", "between", "1997", "and", "2007", "in", "Western", "Washington...
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We evaluated the association between the BRAF c.1799T>A (p.V600E) mutation and survival in individuals with incident invasive CRC diagnosed between 1997 and 2007 in Western Washington State. Tumor specimens were tested for this BRAF mutation and MSI BRAF mutation and MSI status. We used Cox regression to estimate H...
22899730
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
22899730
[ "Among", "1,980", "cases", "tested,", "12%", "were", "BRAF", "c.1799T>A", "(p.V600E)", "mutation-positive", "(n", "=", "247).", "BRAF-mutated", "CRC", "was", "associated", "with", "poorer", "disease-specific", "survival", "adjusting", "for", "age,", "sex,", "time", ...
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Among 1,980 cases tested, 12% were BRAF c.1799T>A (p.V600E) mutation-positive (n = 247). BRAF-mutated CRC was associated with poorer disease-specific survival adjusting for age, sex, time from diagnosis to enrollment, stage, and MSI status (HR, 1.43; 95% CI, 1.05-1.95). This association was limited to cases diagnosed a...
22899730
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
22899730
[ "Our", "results", "show", "that", "the", "prevalence", "of", "BRAF", "mutations", "in", "CRC", "differs", "by", "patient", "and", "tumor", "characteristics", "and", "suggest", "that", "the", "association", "between", "BRAF", "status", "and", "CRC", "survival", ...
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Our results show that the prevalence of BRAF mutations in CRC differs by patient and tumor characteristics and suggest that the association between BRAF status and CRC survival may differ by some of these factors.
22899730
[ "##", "IMPACT" ]
[ 0, 0 ]
## IMPACT
22899730
[ "The", "presence", "of", "a", "BRAF", "c.1799T>A", "(p.V600E)", "mutation", "mutation", " ", "and", "MSI", "status.", "We", "used", "Cox", "regression", "to", "estimate", "HRs", "and", "95%", "confidence", "intervals", "(CI)", "for", "the", "association", "bet...
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The presence of a BRAF c.1799T>A (p.V600E) mutation mutation and MSI status. We used Cox regression to estimate HRs and 95% confidence intervals (CI) for the association between BRAF mutation status and disease-specific and overall survival. Stratified analyses were conducted by age, sex, tumor site, stage, and MSI s...
22899730
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
22899730
[ "Among", "1,980", "cases", "tested,", "12%", "were", "BRAF", "c.1799T>A", "(p.V600E)", "mutation-positive", "(n", "=", "247).", "BRAF-mutated", "CRC", "was", "associated", "with", "poorer", "disease-specific", "survival", "adjusting", "for", "age,", "sex,", "time", ...
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Among 1,980 cases tested, 12% were BRAF c.1799T>A (p.V600E) mutation-positive (n = 247). BRAF-mutated CRC was associated with poorer disease-specific survival adjusting for age, sex, time from diagnosis to enrollment, stage, and MSI status (HR, 1.43; 95% CI, 1.05-1.95). This association was limited to cases diagnosed a...
22899730
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
22899730
[ "Our", "results", "show", "that", "the", "prevalence", "of", "BRAF", "mutations", "in", "CRC", "differs", "by", "patient", "and", "tumor", "characteristics", "and", "suggest", "that", "the", "association", "between", "BRAF", "status", "and", "CRC", "survival", ...
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Our results show that the prevalence of BRAF mutations in CRC differs by patient and tumor characteristics and suggest that the association between BRAF status and CRC survival may differ by some of these factors.
22899730
[ "##", "IMPACT" ]
[ 0, 0 ]
## IMPACT
22899730
[ "The", "presence", "of", "a", "BRAF", "c.1799T>A", "(p.V600E)", "mutation", "is", "associated", "with", "significantly", "poorer", "prognosis", "after", "CRC", "diagnosis", "among", "subgroups", "of", "patients." ]
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The presence of a BRAF c.1799T>A (p.V600E) mutation is associated with significantly poorer prognosis after CRC diagnosis among subgroups of patients.
22899730
[]
[]
21479914
[ "Variation", "in", "the", "CYP19A1", "gene", "and", "risk", "of", "colon", "and", "rectal", "cancer." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
Variation in the CYP19A1 gene and risk of colon and rectal cancer.
21479914
[ "CYP19A1,", "or", "aromatase,", "influences", "estrogen-metabolizing", "enzymes", "and", "may", "influence", "cancer", "risk.", "We", "examine", "variation", "in", "the", "CYP19A1", "gene", "and", "risk", "of", "colorectal", "cancer", "using", "data", "from", "pop...
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CYP19A1, or aromatase, influences estrogen-metabolizing enzymes and may influence cancer risk. We examine variation in the CYP19A1 gene and risk of colorectal cancer using data from population-based case-control studies (colon n = 1,574 cases, 1,970 controls; rectal n = 791 cases, 999 controls). Four SNPs were statisti...
21479914
[ "CYP19A1,", "or", "aromatase,", "influences", "estrogen-metabolizing", "enzymes", "and", "may", "influence", "cancer", "risk.", "We", "examine", "variation", "CYP19A1", ",", "or", "aromatase,", "influences", "estrogen-metabolizing", "enzymes", "and", "may", "influence",...
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CYP19A1, or aromatase, influences estrogen-metabolizing enzymes and may influence cancer risk. We examine variation CYP19A1 , or aromatase, influences estrogen-metabolizing enzymes and may influence cancer risk. We examine variation in the CYP19A1 gene and risk of colorectal cancer using data from population-based case...
21479914
[]
[]
27070770
[ "[Rare", "hereditary", "syndromes", "associated", "with", "polyposis", "and", "the", "development", "of", "malignant", "tumors].", "\n\n\n", "##", "UNLABELLED" ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
[Rare hereditary syndromes associated with polyposis and the development of malignant tumors]. ## UNLABELLED
27070770
[ "Familial", "adenomatous", "polyposis", "(FAP)", "and", "Peutz-Jeghers", "syndrome", "are", "genetic", "diseases", "characterized", "by", "gastrointestinal", "polyps,", "extraintestinal", "manifestations,", "and", "autosomal", "dominant", "inheritance.", "The", "carriers", ...
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Familial adenomatous polyposis (FAP) and Peutz-Jeghers syndrome are genetic diseases characterized by gastrointestinal polyps, extraintestinal manifestations, and autosomal dominant inheritance. The carriers of these diseases from early childhood are at risk for neoplasias at different sites, which are symptomatic at v...
27070770
[ "##", "AIM" ]
[ 0, 0 ]
## AIM
27070770
[ "to", "study", "the", "clinical", "organ-specific", "manifestations", "in", "patients", "with", "FAP", "and", "Peutz-Jeghers,", "genetics", "update", "and", "possibilities", "of", "diagnosis,", "monitoring,", "and", "treatment", "of", "these", "diseases." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
to study the clinical organ-specific manifestations in patients with FAP and Peutz-Jeghers, genetics update and possibilities of diagnosis, monitoring, and treatment of these diseases.
27070770
[ "##", "MATERIAL", "AND", "METHODS" ]
[ 0, 0, 0, 0 ]
## MATERIAL AND METHODS
27070770
[ "The", "authors", "give", "the", "results", "of", "their", "examination", "and", "follow-up", "of", "children", "with", "FAP", "and", "Peutz-Jeghers", "hamartoma-polypous", "syndrome.", "In", "addition,", "current", "data", "from", "PubMed,", "Medline", "(including"...
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The authors give the results of their examination and follow-up of children with FAP and Peutz-Jeghers hamartoma-polypous syndrome. In addition, current data from PubMed, Medline (including reviews, original articles and case reports) were used.
27070770
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
27070770
[ "The", "main", "clinical", "organ-specific", "signs", "of", "multiple", "tumors", "in", "FAP", "and", "Peutz-Jeghers", "syndrome", "are", "shown.", "Data", "on", "the", "assessment", "of", "a", "risk", "for", "malignant", "tumors", "at", "various", "sites", "i...
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The main clinical organ-specific signs of multiple tumors in FAP and Peutz-Jeghers syndrome are shown. Data on the assessment of a risk for malignant tumors at various sites in the affected patients and their family members at different ages are provided. Each of these syndromes has a dissimilar genetic foundation. FAP...
27070770
[ "##", "CONCLUSION" ]
[ 0, 0 ]
## CONCLUSION
27070770
[ "Molecular", "genetic", "testing", "of", "the", "genes", "associated", "with", "FAP", "and", "Peutz-Jeghers", "syndromes", "makes", "it", "possible", "to", "timely", "recognize", "family", "members", "at", "high", "risk,", "to", "plan", "therapeutic", "strategy", ...
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Molecular genetic testing of the genes associated with FAP and Peutz-Jeghers syndromes makes it possible to timely recognize family members at high risk, to plan therapeutic strategy and to affect the course of a disease. The joint participation of pediatricians, proctologists, oncologists, morphologists, geneticists, ...
27070770
[]
[]
23603433
[ "Instability", "at", "the", "FRA8I", "common", "fragile", "site", "disrupts", "the", "genomic", "integrity", "of", "the", "KIAA0146,", "CEBPD", "and", "PRKDC", "genes", "in", "colorectal", "cancer." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
Instability at the FRA8I common fragile site disrupts the genomic integrity of the KIAA0146, CEBPD and PRKDC genes in colorectal cancer.
23603433
[ "Specific", "patterns", "of", "genomic", "aberrations", "have", "been", "associated", "with", "different", "types", "of", "malignancies.", "In", "colorectal", "cancer,", "losses", "of", "chromosome", "arm", "8p", "and", "gains", "of", "chromosome", "arm", "8q", ...
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Specific patterns of genomic aberrations have been associated with different types of malignancies. In colorectal cancer, losses of chromosome arm 8p and gains of chromosome arm 8q are among the most common chromosomal rearrangements, suggesting that the centromeric portion of chromosome 8 is particularly sensitive to ...
23603433
[ "Specific", "patterns", "of", "genomic", "aberrations", "have", "been", "associated", "with", "different", "types", "of", "malignancies.", "In", "colorectal", "cancer,", "losses", "of", "chromosome", "arm", "8p", "and", "gains", "of", "chromosome", "arm", "8q", ...
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...
Specific patterns of genomic aberrations have been associated with different types of malignancies. In colorectal cancer, losses of chromosome arm 8p and gains of chromosome arm 8q are among the most common chromosomal rearrangements, suggesting that the centromeric portion of chromosome 8 is particularly sensitive t...
23603433
[ "Specific", "patterns", "of", "genomic", "aberrations", "have", "been", "associated", "with", "different", "types", "of", "malignancies.", "In", "colorectal", "cancer,", "losses", "of", "chromosome", "arm", "8p", "and", "gains", "of", "chromosome", "arm", "8q", ...
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Specific patterns of genomic aberrations have been associated with different types of malignancies. In colorectal cancer, losses of chromosome arm 8p and gains of chromosome arm 8q are among the most common chromosomal rearrangements, suggesting that the centromeric portion of chromosome 8 is particularly sensitive to ...
23603433
[ "Specific", "patterns", "of", "genomic", "aberrations", "have", "been", "associated", "with", "different", "types", "of", "malignancies.", "In", "colorectal", "cancer,", "losses", "of", "chromosome", "arm", "8p", "and", "gains", "of", "chromosome", "arm", "8q", ...
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Specific patterns of genomic aberrations have been associated with different types of malignancies. In colorectal cancer, losses of chromosome arm 8p and gains of chromosome arm 8q are among the most common chromosomal rearrangements, suggesting that the centromeric portion of chromosome 8 is particularly sensitive to ...
23603433
[]
[]
26925673
[ "Impact", "of", "Cellular", "Genetic", "Make-up", "on", "Colorectal", "Cancer", "Cell", "Lines", "Response", "to", "Ellagic", "Acid:", "Implications", "of", "Small", "Interfering", "RNA.", "\n\n\n", "##", "BACKGROUND" ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
Impact of Cellular Genetic Make-up on Colorectal Cancer Cell Lines Response to Ellagic Acid: Implications of Small Interfering RNA. ## BACKGROUND
26925673
[ "K-Ras", "activation", "is", "an", "early", "event", "in", "colorectal", "carcinogenesis", "and", "associated", "mutations", "have", "been", "reported", "in", "about", "40%", "of", "colorectal", "cancer", "patients.", "These", "mutations", "have", "always", "been"...
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K-Ras activation is an early event in colorectal carcinogenesis and associated mutations have been reported in about 40% of colorectal cancer patients. These mutations have always been responsible for enhancing malignancy and silencing them is associated with attenuation of tumorigenicity. Among downstream effectors ar...
26925673
[ "##", "PURPOSE" ]
[ 0, 0 ]
## PURPOSE
26925673
[ "To", "evaluate", "the", "impact", "of", "cellular", "genetic", "make-", "up", "of", "two", "colon", "cancer", "cell", "lines", "with", "different", "genetic", "backgrounds,", "HCT-116", "(K-Ras-/p53+)", "and", "Caco-2", "(K-Ras+/", "p53-),", "on", "response", "...
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To evaluate the impact of cellular genetic make- up of two colon cancer cell lines with different genetic backgrounds, HCT-116 (K-Ras-/p53+) and Caco-2 (K-Ras+/ p53-), on response to potential anti-tumour effects of EA. In addition, the influence of K-Ras silencing in HCT- 116 cells was investigated.
26925673
[ "##", "MATERIALS", "AND", "METHODS" ]
[ 0, 0, 0, 0 ]
## MATERIALS AND METHODS