Brizape/amia_split_0404 · Datasets at Hugging Face

id stringlengths 7 8	tokens list	ner_tags list	texts stringlengths 0 8.69k
25374237	[ "Individuals", "with", "-31C", "allele", "and", "CC", "genotype", "were", "found", "to", "have", "a", "higher", "risk", "of", "developing", "colon", "cancer", "(OR=13.4,", "p=0.01).", "The", "-241", "CT", "genotype", "considerably", "increased", "the", "risk", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 1, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	Individuals with -31C allele and CC genotype were found to have a higher risk of developing colon cancer (OR=13.4, p=0.01). The -241 CT genotype considerably increased the risk of colon cancer (OR=12.0, p=0.0001). However, there was no significant varaition of the survivin -625 C/G polymorphism survivin polymorphisms ...
25374237	[ "##", "MATERIALS", "AND", "METHODS" ]	[ 0, 0, 0, 0 ]	## MATERIALS AND METHODS
25374237	[ "The", "relation", "between", "colon", "cancer", "and", "survivin", "-31", "G/C", "(rs9904341),", "-241", "C/T", "(rs17878467)", "and", "-625", "C/G", "(rs8073069)", "polymorphism", "in", "promotor", "site", "of", "survivin", "gene", "associated", "with", "apoptos...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	The relation between colon cancer and survivin -31 G/C (rs9904341), -241 C/T (rs17878467) and -625 C/G (rs8073069) polymorphism in promotor site of survivin gene associated with apoptosis was investigated using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
25374237	[ "##", "RESULTS" ]	[ 0, 0 ]	## RESULTS
25374237	[ "Individuals", "with", "-31C", "allele", "and", "CC", "genotype", "were", "found", "to", "have", "a", "higher", "risk", "of", "developing", "colon", "cancer", "(OR=13.4,", "p=0.01).", "The", "-241", "CT", "genotype", "considerably", "increased", "the", "risk", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Individuals with -31C allele and CC genotype were found to have a higher risk of developing colon cancer (OR=13.4, p=0.01). The -241 CT genotype considerably increased the risk of colon cancer (OR=12.0, p=0.0001). However, there was no significant varaition of the survivin -625 C/G polymorphism among colon cancer patie...
25374237	[ "##", "CONCLUSIONS" ]	[ 0, 0 ]	## CONCLUSIONS
25374237	[ "This", "study", "provides", "the", "first", "evidence", "that", "survivin", "-31", "G/C", "and", "-241", "C/T", "SNP", "significantly", "contribute", "to", "the", "risk", "of", "colon", "cancer", "in", "the", "Turkish", "population." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	This study provides the first evidence that survivin -31 G/C and -241 C/T SNP significantly contribute to the risk of colon cancer in the Turkish population.
25374237	[]	[]
24196785	[ "Amplification", "of", "PVT-1", "is", "involved", "in", "poor", "prognosis", "via", "apoptosis", "inhibition", "in", "colorectal", "cancers.", "\n\n\n", "##", "BACKGROUND" ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers. ## BACKGROUND
24196785	[ "We", "previously", "conducted", "gene", "expression", "microarray", "analyses", "to", "identify", "novel", "indicators", "for", "colorectal", "cancer", "(CRC)", "metastasis", "and", "prognosis", "from", "which", "we", "identified", "PVT-1", "as", "a", "candidate", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	We previously conducted gene expression microarray analyses to identify novel indicators for colorectal cancer (CRC) metastasis and prognosis from which we identified PVT-1 as a candidate gene. PVT-1, which encodes a long noncoding RNA, mapped to chromosome 8q24 whose copy-number amplification is one of the most freque...
24196785	[ "##", "METHODS" ]	[ 0, 0 ]	## METHODS
24196785	[ "We", "conducted", "cell", "proliferation", "and", "invasion", "assays", "using", "colorectal", "cancer", "cell", "lines", "transfected", "with", "PVT-1siRNA", "or", "negative", "control", "siRNA.", "Gene", "expression", "microarray", "analyses", "on", "these", "cel...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	We conducted cell proliferation and invasion assays using colorectal cancer cell lines transfected with PVT-1siRNA or negative control siRNA. Gene expression microarray analyses on these cell lines were also carried out to investigate the molecular function of PVT-1. Further, we investigated the impact of PVT-1 expre...
24196785	[ "##", "RESULTS" ]	[ 0, 0 ]	## RESULTS
24196785	[ "CRC", "cells", "transfected", "with", "PVT-1", " ", "siRNA", "exhibited", "significant", "loss", "of", "their", "proliferation", "and", "invasion", "capabilities.", "In", "these", "cells,", "the", "TGF-β", "signalling", "pathway", "and", "apoptotic", "signals", "...	[ 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	CRC cells transfected with PVT-1 siRNA exhibited significant loss of their proliferation and invasion capabilities. In these cells, the TGF-β signalling pathway and apoptotic signals were significantly activated. In addition, univariate and multivariate analysis revealed that PVT-1 TGF-β signalling pathway and apop...
24196785	[ "##", "CONCLUSION" ]	[ 0, 0 ]	## CONCLUSION
24196785	[ "PVT-1,", "which", "maps", "to", "8q24", "PVT-1", ",", "which", "maps", "to", "8q24,", "generates", "antiapoptotic", "activity", "in", "CRC,", "and", "abnormal", "expression", "of", "PVT-1", "PVT-1", "PVT-1", " ", "is", "involved", "in", "poor", "prognosis", ...	[ 0, 0, 0, 0, 7, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	PVT-1, which maps to 8q24 PVT-1 , which maps to 8q24, generates antiapoptotic activity in CRC, and abnormal expression of PVT-1 PVT-1 PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers. ## BACKGROUND
24196785	[ "We", "previously", "conducted", "gene", "expression", "microarray", "analyses", "to", "identify", "novel", "indicators", "for", "colorectal", "cancer", "(CRC)", "metastasis", "and", "prognosis", "from", "which", "we", "identified", "PVT-1", "as", "a", "candidate", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	We previously conducted gene expression microarray analyses to identify novel indicators for colorectal cancer (CRC) metastasis and prognosis from which we identified PVT-1 as a candidate gene. PVT-1 , which encodes a long noncoding RNA, mapped to chromosome 8q24 whose copy-number amplification is one of the most fre...
24196785	[ "##", "METHODS" ]	[ 0, 0 ]	## METHODS
24196785	[ "We", "conducted", "cell", "proliferation", "and", "invasion", "assays", "using", "colorectal", "cancer", "cell", "lines", "transfected", "with", "PVT-1", "Amplification", " ", "of", "PVT-1", "is", "involved", "in", "poor", "prognosis", "via", "apoptosis", "inhibi...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	We conducted cell proliferation and invasion assays using colorectal cancer cell lines transfected with PVT-1 Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers. ## BACKGROUND
24196785	[ "We", "previously", "conducted", "gene", "expression", "microarray", "analyses", "to", "identify", "novel", "indicators", "for", "colorectal", "cancer", "(CRC)", "metastasis", "and", "prognosis", "from", "which", "we", "identified", "PVT-1", "as", "a", "candidate", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0...	We previously conducted gene expression microarray analyses to identify novel indicators for colorectal cancer (CRC) metastasis and prognosis from which we identified PVT-1 as a candidate gene. PVT-1, which encodes a long noncoding RNA, mapped to chromosome 8q24 whose copy-number amplification is one of the most freq...
24196785	[ "##", "METHODS" ]	[ 0, 0 ]	## METHODS
24196785	[ "We", "conducted", "cell", "proliferation", "and", "invasion", "assays", "using", "colorectal", "cancer", "cell", "lines", "transfected", "with", "PVT-1siRNA", "or", "negative", "control", "siRNA.", "Gene", "expression", "microarray", "analyses", "on", "these", "cel...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	We conducted cell proliferation and invasion assays using colorectal cancer cell lines transfected with PVT-1siRNA or negative control siRNA. Gene expression microarray analyses on these cell lines were also carried out to investigate the molecular function of PVT-1 . Further, we investigated the impact of PVT-1 expres...
24196785	[ "##", "RESULTS" ]	[ 0, 0 ]	## RESULTS
24196785	[ "CRC", "cells", "transfected", "with", "PVT-1", "siRNA", "exhibited", "significant", "loss", "of", "their", "proliferation", "and", "invasion", "capabilities.", "In", "these", "cells,", "the", "TGF-β", "signalling", "pathway", "and", "apoptotic", "signals", "were", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	CRC cells transfected with PVT-1 siRNA exhibited significant loss of their proliferation and invasion capabilities. In these cells, the TGF-β signalling pathway and apoptotic signals were significantly activated. In addition, univariate and multivariate analysis revealed that PVT-1 expression level was an independent r...
24196785	[ "##", "CONCLUSION" ]	[ 0, 0 ]	## CONCLUSION
24196785	[ "PVT-1,", "which", "maps", "to", "8q24,", "generates", "antiapoptotic", "activity", "in", "CRC,", "and", "abnormal", "expression", "of", "PVT-1", "was", "a", "prognostic", "indicator", "for", "CRC", "patients." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	PVT-1, which maps to 8q24, generates antiapoptotic activity in CRC, and abnormal expression of PVT-1 was a prognostic indicator for CRC patients.
24196785	[]	[]
1299227	[ "Colorectal", "carcinoma.", "DNA", "ploidy", "pattern", "and", "prognosis", "with", "reference", "to", "tumor", "DNA", "heterogeneity." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Colorectal carcinoma. DNA ploidy pattern and prognosis with reference to tumor DNA heterogeneity.
1299227	[ "Nuclear", "DNA", "content", "was", "measured", "in", "72", "colorectal", "carcinomas", "using", "single-cell", "microspectrophotometry", "on", "Feulgen-stained", "smears.", "Four", "samples", "were", "analyzed", "from", "each", "tumor.", "Patients", "were", "followed...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3...	Nuclear DNA content was measured in 72 colorectal carcinomas using single-cell microspectrophotometry on Feulgen-stained smears. Four samples were analyzed from each tumor. Patients were followed for 41-65 months (average, 53). DNA heterogeneity (both aneuploid and nonaneuploid patterns) was present in 44% of the cases...
1299227	[ "Nuclear", "DNA", "content", "was", "measured", "in", "72", "colorectal", "carcinomas", "using", "single-cell", "microspectrophotometry", "on", "Feulgen-stained", "smears.", "Four", "samples", "were", "analyzed", "from", "each", "tumor.", "Patients", "were", "followed...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	Nuclear DNA content was measured in 72 colorectal carcinomas using single-cell microspectrophotometry on Feulgen-stained smears. Four samples were analyzed from each tumor. Patients were followed for 41-65 months (average, 53). DNA heterogeneity (both aneuploid and nonaneuploid patterns) was present in 44% of the cases...
1299227	[]	[]
26302849	[ "Polymorphisms", "of", "PRLHR", "and", "HSPA12A", "and", "risk", "of", "gastric", "and", "colorectal", "cancer", "in", "the", "Chinese", "Han", "population.", "\n\n\n", "##", "BACKGROUND" ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Polymorphisms of PRLHR and HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population. ## BACKGROUND
26302849	[ "Gastric", "and", "colorectal", "cancers", "have", "a", "major", "impact", "on", "public", "health,", "and", "are", "the", "most", "common", "malignant", "tumors", "in", "China.", "The", "aim", "of", "this", "research", "was", "to", "study", "whether", "poly...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Gastric and colorectal cancers have a major impact on public health, and are the most common malignant tumors in China. The aim of this research was to study whether polymorphisms of CHCHD3P1-HSP90AB7P, GRID1, HSPA12A, PRLHR, SBF2, POLD3 and C11orf93-C11orf92 genes are associated with the risk of gastric and colorectal...
26302849	[ "##", "METHODS" ]	[ 0, 0 ]	## METHODS
26302849	[ "We", "genotyped", "seven", "single", "nucleotide", "polymorphisms", " ", "(SNPs)", "from", "seven", "genes.", "We", "selected", "588", "patients", "with", "gastric", "cancer", "and", "449", "with", "colorectal", "cancer,", "along", "with", "703", "healthy", "co...	[ 0, 0, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	We genotyped seven single nucleotide polymorphisms (SNPs) from seven genes. We selected 588 patients with gastric cancer and 449 with colorectal cancer, along with 703 healthy controls. All these SNPs were evaluated using the χ² test and genetic model analysis.
26302849	[ "##", "RESULTS" ]	[ 0, 0 ]	## RESULTS
26302849	[ "The", "genotype", "\"A/T\"", "of", "rs12413624", "in", "PRLHR", "gene", "was", "associated", "with", "a", "decreased", "risk", "of", "colorectal", "cancer", "in", "allele", "model", "analysis", "[odds", "ratio", "(OR)", " ", "=", " ", "0.81;", "95%", "confi...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	The genotype "A/T" of rs12413624 in PRLHR gene was associated with a decreased risk of colorectal cancer in allele model analysis [odds ratio (OR) = 0.81; 95% confidence interval (CI) = 0.68-0.97; p = 0.018] and log-additive model analysis (OR = 0.81; 95% CI = 0.66-0.98; p = 0.032). The genotype...
26302849	[ "##", "CONCLUSIONS" ]	[ 0, 0 ]	## CONCLUSIONS
26302849	[ "Our", "results", "provide", "evidence", "that", "variants", " ", "of", "PRLHR", "gene", "are", "a", "protective", "factor", "in", "colorectal", "cancer", "and", "variants", "C11orf93-C11orf92", " ", "genes", "are", "associated", "with", "the", "risk", "of", "...	[ 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Our results provide evidence that variants of PRLHR gene are a protective factor in colorectal cancer and variants C11orf93-C11orf92 genes are associated with the risk of gastric and colorectal cancers in the Chinese Han population.
26302849	[ "##", "METHODS" ]	[ 0, 0 ]	## METHODS
26302849	[ "We", "genotyped", "seven", "single", "nucleotide", "polymorphisms", "(", "SNPs", ")", "from", "seven", "genes.", "We", "selected", "588", "patients", "with", "gastric", "cancer", "and", "449", "with", "colorectal", "cancer,", "along", "with", "703", "healthy", ...	[ 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	We genotyped seven single nucleotide polymorphisms ( SNPs ) from seven genes. We selected 588 patients with gastric cancer and 449 with colorectal cancer, along with 703 healthy controls. All these SNPs Polymorphisms of PRLHR and HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population. ## ...
26302849	[ "Gastric", "and", "colorectal", "cancers", "have", "a", "major", "impact", "on", "public", "health,", "and", "are", "the", "most", "common", "malignant", "tumors", "in", "China.", "The", "aim", "of", "this", "research", "was", "to", "study", "whether", "poly...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 1, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Gastric and colorectal cancers have a major impact on public health, and are the most common malignant tumors in China. The aim of this research was to study whether polymorphisms of CHCHD3P1-HSP90AB7P, GRID1 , HSPA12A , PRLHR , SBF2 , POLD3 and C11orf93-C11orf92 genes are associated with the risk of gastric and colo...
26302849	[ "##", "METHODS" ]	[ 0, 0 ]	## METHODS
26302849	[ "We", "genotyped", "seven", "single", "nucleotide", "polymorphisms", "(SNPs)", "from", "seven", "genes.", "We", "selected", "588", "patients", "with", "gastric", "cancer", "and", "449", "with", "colorectal", "cancer,", "along", "with", "703", "healthy", "controls....	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	We genotyped seven single nucleotide polymorphisms (SNPs) from seven genes. We selected 588 patients with gastric cancer and 449 with colorectal cancer, along with 703 healthy controls. All these SNPs were evaluated using the χ² test and genetic model analysis.
26302849	[ "##", "RESULTS" ]	[ 0, 0 ]	## RESULTS
26302849	[ "The", "genotype", "\"A/T\"", "of", "rs12413624", " ", "in", "PRLHR", "gene", "was", "associated", "with", "a", "decreased", "risk", "of", "colorectal", "cancer", "in", "allele", "model", "analysis", "[odds", "ratio", "(OR)", " ", "=", " ", "0.81;", "95%", ...	[ 0, 0, 0, 0, 11, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, ...	The genotype "A/T" of rs12413624 in PRLHR gene was associated with a decreased risk of colorectal cancer in allele model analysis [odds ratio (OR) = 0.81; 95% confidence interval (CI) = 0.68-0.97; p = 0.018] and log-additive model analysis (OR = 0.81; 95% CI = 0.66-0.98; p = 0.032). The genoty...
26302849	[ "##", "CONCLUSIONS" ]	[ 0, 0 ]	## CONCLUSIONS
26302849	[ "Our", "results", "provide", "evidence", "that", "variants", "of", "PRLHR", "HSPA12A", "PRLHR", " ", "and", "HSPA12A", "and", "risk", "of", "gastric", "and", "colorectal", "cancer", "in", "the", "Chinese", "Han", "population.", "\n\n\n", "##", "BACKGROUND" ]	[ 0, 0, 0, 0, 0, 0, 0, 1, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Our results provide evidence that variants of PRLHR HSPA12A PRLHR and HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population. ## BACKGROUND
26302849	[ "Gastric", "and", "colorectal", "cancers", "have", "a", "major", "impact", "on", "public", "health,", "and", "are", "the", "most", "common", "malignant", "tumors", "in", "China.", "The", "aim", "of", "this", "research", "was", "to", "study", "whether", "poly...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Gastric and colorectal cancers have a major impact on public health, and are the most common malignant tumors in China. The aim of this research was to study whether polymorphisms of CHCHD3P1-HSP90AB7P, GRID1, HSPA12A, PRLHR, SBF2, POLD3 and C11orf93-C11orf92 genes are associated with the risk of gastric and colorectal...
26302849	[ "##", "METHODS" ]	[ 0, 0 ]	## METHODS
26302849	[ "We", "genotyped", "seven", "single", "nucleotide", "polymorphisms", "(SNPs)", "from", "seven", "genes.", "We", "selected", "588", "patients", "with", "gastric", "cancer", "and", "449", "with", "colorectal", "cancer,", "along", "with", "703", "healthy", "controls....	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	We genotyped seven single nucleotide polymorphisms (SNPs) from seven genes. We selected 588 patients with gastric cancer and 449 with colorectal cancer, along with 703 healthy controls. All these SNPs were evaluated using the χ² test and genetic model analysis.
26302849	[ "##", "RESULTS" ]	[ 0, 0 ]	## RESULTS
26302849	[ "The", "genotype", "\"A/T\"", "of", "rs12413624", "in", "PRLHR", "gene", "was", "associated", "with", "a", "decreased", "risk", "of", "colorectal", "cancer", "in", "allele", "model", "analysis", "[odds", "ratio", "(OR)", " ", "=", " ", "0.81;", "95%", "confi...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	The genotype "A/T" of rs12413624 in PRLHR gene was associated with a decreased risk of colorectal cancer in allele model analysis [odds ratio (OR) = 0.81; 95% confidence interval (CI) = 0.68-0.97; p = 0.018] and log-additive model analysis (OR = 0.81; 95% CI = 0.66-0.98; p = 0.032). The genotype...
26302849	[ "##", "CONCLUSIONS" ]	[ 0, 0 ]	## CONCLUSIONS
26302849	[ "Our", "results", "provide", "evidence", "that", "variants", "of", "PRLHR", "gene", "are", "a", "protective", "factor", "in", "colorectal", "cancer", "and", "variants", "of", "HSPA12A", "HSPA12A", " ", "and", "risk", "of", "gastric", "and", "colorectal", "canc...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Our results provide evidence that variants of PRLHR gene are a protective factor in colorectal cancer and variants of HSPA12A HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population. ## BACKGROUND
26302849	[ "Gastric", "and", "colorectal", "cancers", "have", "a", "major", "impact", "on", "public", "health,", "and", "are", "the", "most", "common", "malignant", "tumors", "in", "China.", "The", "aim", "of", "this", "research", "was", "to", "study", "whether", "poly...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Gastric and colorectal cancers have a major impact on public health, and are the most common malignant tumors in China. The aim of this research was to study whether polymorphisms of CHCHD3P1-HSP90AB7P , GRID1, HSPA12A, PRLHR, SBF2, POLD3 and C11orf93-C11orf92 genes are associated with the risk of gastric and colorec...
26302849	[ "##", "METHODS" ]	[ 0, 0 ]	## METHODS
26302849	[ "We", "genotyped", "seven", "single", "nucleotide", "polymorphisms", "(SNPs)", "from", "seven", "genes.", "We", "selected", "588", "patients", "with", "gastric", "cancer", "and", "449", "with", "colorectal", "cancer,", "along", "with", "703", "healthy", "controls....	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	We genotyped seven single nucleotide polymorphisms (SNPs) from seven genes. We selected 588 patients with gastric cancer and 449 with colorectal cancer, along with 703 healthy controls. All these SNPs were evaluated using the χ² test and genetic model analysis.
26302849	[ "##", "RESULTS" ]	[ 0, 0 ]	## RESULTS
26302849	[ "The", "genotype", "\"A/T\"", "of", "rs12413624", "in", "PRLHR", "gene", "was", "associated", "with", "a", "decreased", "risk", "of", "colorectal", "cancer", "in", "allele", "model", "analysis", "[odds", "ratio", "(OR)", " ", "=", " ", "0.81;", "95%", "confi...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	The genotype "A/T" of rs12413624 in PRLHR gene was associated with a decreased risk of colorectal cancer in allele model analysis [odds ratio (OR) = 0.81; 95% confidence interval (CI) = 0.68-0.97; p = 0.018] and log-additive model analysis (OR = 0.81; 95% CI = 0.66-0.98; p = 0.032). The genotype...
26302849	[ "##", "CONCLUSIONS" ]	[ 0, 0 ]	## CONCLUSIONS
26302849	[ "Our", "results", "provide", "evidence", "that", "variants", "of", "PRLHR", "gene", "are", "a", "protective", "factor", "in", "colorectal", "cancer", "and", "variants", "of", "HSPA12A", "gene", "are", "a", "protective", "factor", "in", "gastric", "cancer", "in...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Our results provide evidence that variants of PRLHR gene are a protective factor in colorectal cancer and variants of HSPA12A gene are a protective factor in gastric cancer in the Chinese Han population.
26302849	[]	[]
26710976	[ "Mismatch", "repair", "defects", "and", "Lynch", "syndrome:", "The", "role", "of", "the", "basic", "scientist", "in", "the", "battle", "against", "cancer." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Mismatch repair defects and Lynch syndrome: The role of the basic scientist in the battle against cancer.
26710976	[ "We", "have", "currently", "entered", "a", "genomic", "era", "of", "cancer", "research", "which", "may", "soon", "lead", "to", "a", "genomic", "era", "of", "cancer", "treatment.", "Patient", "DNA", "sequencing", "information", "may", "lead", "to", "a", "pers...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	We have currently entered a genomic era of cancer research which may soon lead to a genomic era of cancer treatment. Patient DNA sequencing information may lead to a personalized approach to managing an individual's cancer as well as future cancer risk. The success of this approach, however, begins not necessarily in t...
26710976	[]	[]
18097606	[ "Transcriptional", "regulation", "of", "the", "COX-2", "expression", "by", "nitric", "oxide", "in", "colon", "cancer", "cell", "lines." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Transcriptional regulation of the COX-2 expression by nitric oxide in colon cancer cell lines.
18097606	[ "To", "determine", "the", "effect", "of", "nitric", "oxide", "(NO)", "on", "the", "cyclooxygenase-2", "(COX-2)", "regulation", "in", "colon", "cancer", "cell", "lines", "we", "used", "the", "physiological", "NO", "donor", "GSNO.", "The", "proximal", "6.6", "kb...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	To determine the effect of nitric oxide (NO) on the cyclooxygenase-2 (COX-2) regulation in colon cancer cell lines we used the physiological NO donor GSNO. The proximal 6.6 kb of the COX-2 promoter was cloned into the pGL3 basic vector and the sequential deletion of the 6.6 kb promoter was cloned into the pGL3 basic ...
18097606	[ "To", "determine", "the", "effect", "of", "nitric", "oxide", "(NO)", "on", "the", "cyclooxygenase-2", "(", "COX-2", "cyclooxygenase-2", " ", "(COX-2)", "regulation", "in", "colon", "cancer", "cell", "lines", "we", "used", "the", "physiological", "NO", "donor", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	To determine the effect of nitric oxide (NO) on the cyclooxygenase-2 ( COX-2 cyclooxygenase-2 (COX-2) regulation in colon cancer cell lines we used the physiological NO donor GSNO. The proximal 6.6 kb of the COX-2 promoter was cloned into the pGL3 basic vector and the sequential deletion of the 6.6 kb COX-2 promoter ...
18097606	[]	[]
17007003	[ "Collision", "tumor", "of", "the", "rectum:", "a", "case", "report", "of", "metastatic", "gastric", "adenocarcinoma", "plus", "primary", "rectal", "adenocarcinoma." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Collision tumor of the rectum: a case report of metastatic gastric adenocarcinoma plus primary rectal adenocarcinoma.
17007003	[ "Collision", "tumors", "are", "thought", "to", "arise", "from", "the", "accidental", "meeting", "and", "interpenetration", "of", "two", "independent", "tumors.", "We", "report", "here", "a", "highly", "unusual", "case", "of", "a", "61-year", "old", "man", "who...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	Collision tumors are thought to arise from the accidental meeting and interpenetration of two independent tumors. We report here a highly unusual case of a 61-year old man who had a unique tumor that was composed of a metastatic adenocarcinoma from the stomach to the rectum, which harbored a collision tumor of primary ...
17007003	[]	[]
12000733	[ "CpG", "island", "methylation", "in", "aberrant", "crypt", "foci", "of", "the", "colorectum." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	CpG island methylation in aberrant crypt foci of the colorectum.
12000733	[ "Aberrant", "crypt", "foci", "(ACF)", "are", "postulated", "to", "be", "the", "earliest", "precursor", "lesion", "in", "colorectal", "carcinogenesis,", "and", "CpG", "island", "methylation", "has", "been", "described", "as", "an", "important", "molecular", "pathwa...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 2...	Aberrant crypt foci (ACF) are postulated to be the earliest precursor lesion in colorectal carcinogenesis, and CpG island methylation has been described as an important molecular pathway. We therefore studied methylation in ACF from patients with familial adenomatous polyposis (FAP) or sporadic colorectal cancer. We as...
12000733	[ "Aberrant", "crypt", "foci", "(ACF)", "are", "postulated", "to", "be", "the", "earliest", "precursor", "lesion", "in", "colorectal", "carcinogenesis,", "and", "CpG", "island", "methylation", "CpG", "island", " ", "methylation", "has", "been", "described", "as", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2...	Aberrant crypt foci (ACF) are postulated to be the earliest precursor lesion in colorectal carcinogenesis, and CpG island methylation CpG island methylation has been described as an important molecular pathway. We therefore studied methylation in ACF from patients with familial adenomatous polyposis (FAP) or sporadic...
12000733	[]	[]
9609758	[ "Expression", "of", "transforming", "growth", "factor", "beta", "receptors", "in", "normal", "human", "colon", "and", "sporadic", "adenocarcinomas.", "\n\n\n", "##", "BACKGROUND", "&", "AIMS" ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Expression of transforming growth factor beta receptors in normal human colon and sporadic adenocarcinomas. ## BACKGROUND & AIMS
9609758	[ "An", "absence", "or", "a", "presence", "of", "mutated", "transforming", "growth", "factor", " ", "(TGF)-beta", "receptors", "is", "a", "possible", "hypothesis", "explaining", "the", "resistance", "of", "cancer", "cells", "to", "the", "growth-inhibitory", "effect"...	[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	An absence or a presence of mutated transforming growth factor (TGF)-beta receptors is a possible hypothesis explaining the resistance of cancer cells to the growth-inhibitory effect of TGF-beta. Mutations involving microsatellite-like regions of the type II TGF-beta receptor have been described in subgroups of color...
9609758	[ "##", "METHODS" ]	[ 0, 0 ]	## METHODS
9609758	[ "Thirty-three", "sporadic", "colorectal", "cancers", "and", "20", "normal", "colonic", "tissues", "were", "explored", "by", "immunohistochemistry", "for", "the", "expression", "of", "type", "I", "and", "type", "II", "TGF-beta", "receptors.", "Eighteen", "tumor", "...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Thirty-three sporadic colorectal cancers and 20 normal colonic tissues were explored by immunohistochemistry for the expression of type I and type II TGF-beta receptors. Eighteen tumor and 20 normal samples were used for radioactive thermocycling and sequencing of the two microsatellite-like regions of the type II rece...
9609758	[ "##", "RESULTS" ]	[ 0, 0 ]	## RESULTS
9609758	[ "Both", "receptors", "were", "overexpressed", "in", "tumors", "compared", "with", "normal", "samples.", "There", "was", "a", "relationship", "between", "the", "abundance", "of", "type", "II", "receptor", "expression", "and", "the", "degree", "of", "differentiation...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	Both receptors were overexpressed in tumors compared with normal samples. There was a relationship between the abundance of type II receptor expression and the degree of differentiation of the tumors but not the Dukes' staging or the localization of the neoplasias. No mutation was observed in the microsatellite-like re...
9609758	[ "##", "METHODS" ]	[ 0, 0 ]	## METHODS
9609758	[ "Thirty-three", "sporadic", "colorectal", "cancers", "and", "20", "normal", "colonic", "tissues", "were", "explored", "by", "immunohistochemistry", "for", "the", "expression", "of", "type", "I", "and", "type", "II", "TGF-beta", "receptors.", "Eighteen", "tumor", "...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Thirty-three sporadic colorectal cancers and 20 normal colonic tissues were explored by immunohistochemistry for the expression of type I and type II TGF-beta receptors. Eighteen tumor and 20 normal samples were used for radioactive thermocycling and sequencing of the two microsatellite-like regions of the type II rece...
9609758	[ "##", "RESULTS" ]	[ 0, 0 ]	## RESULTS
9609758	[ "Both", "receptors", "were", "overexpressed", "in", "tumors", "compared", "with", "normal", "samples.", "There", "was", "a", "relationship", "between", "the", "abundance", "of", "type", "II", "receptor", "type", "II", "receptor", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 1, 2, 2, 0 ]	Both receptors were overexpressed in tumors compared with normal samples. There was a relationship between the abundance of type II receptor type II receptor .
9609758	[ "##", "RESULTS" ]	[ 0, 0 ]	## RESULTS
9609758	[ "Both", "receptors", "were", "overexpressed", "in", "tumors", "compared", "with", "normal", "samples.", "There", "was", "a", "relationship", "between", "the", "abundance", "of", "type", "II", "receptor", "expression", "and", "the", "degree", "of", "differentiation...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Both receptors were overexpressed in tumors compared with normal samples. There was a relationship between the abundance of type II receptor expression and the degree of differentiation of the tumors but not the Dukes' staging or the localization of the neoplasias. No mutation was observed in the microsatellite-like re...
9609758	[ "##", "CONCLUSIONS" ]	[ 0, 0 ]	## CONCLUSIONS
9609758	[ "Sporadic", "colorectal", "cancers", "do", "not", "show", "an", "absence", "or", "a", "presence", "of", "mutated", "TGF-beta", "receptors", "mutation", " ", "was", "observed", "in", "the", "microsatellite-like", "regions", "of", "receptor", "II", "in", "any", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Sporadic colorectal cancers do not show an absence or a presence of mutated TGF-beta receptors mutation was observed in the microsatellite-like regions of receptor II in any of the samples.
9609758	[ "##", "CONCLUSIONS" ]	[ 0, 0 ]	## CONCLUSIONS
9609758	[ "Sporadic", "colorectal", "cancers", "do", "not", "show", "an", "absence", "or", "a", "presence", "of", "mutated", "TGF-beta", "receptors", "that", "could", "explain", "a", "resistance", "to", "TGF-beta", "mutated", "transforming", "growth", "factor", "beta", "r...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 3, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Sporadic colorectal cancers do not show an absence or a presence of mutated TGF-beta receptors that could explain a resistance to TGF-beta mutated transforming growth factor beta receptors in normal human colon and sporadic adenocarcinomas. ## BACKGROUND & AIMS
9609758	[ "An", "absence", "or", "a", "presence", "of", "mutated", "transforming", "growth", "factor", "(TGF)-beta", "receptors", "is", "a", "possible", "hypothesis", "explaining", "the", "resistance", "of", "cancer", "cells", "to", "the", "growth-inhibitory", "effect", "of...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	An absence or a presence of mutated transforming growth factor (TGF)-beta receptors is a possible hypothesis explaining the resistance of cancer cells to the growth-inhibitory effect of TGF-beta mutated transforming growth factor (TGF)-beta receptors is a possible hypothesis explaining the resistance of cancer cells ...
9609758	[ "##", "METHODS" ]	[ 0, 0 ]	## METHODS
9609758	[ "Thirty-three", "sporadic", "colorectal", "cancers", "and", "20", "normal", "colonic", "tissues", "were", "explored", "by", "immunohistochemistry", "for", "the", "expression", "of", "type", "I", "and", "type", "II", "TGF-beta", "receptors", ".", "Eighteen", "tumor...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Thirty-three sporadic colorectal cancers and 20 normal colonic tissues were explored by immunohistochemistry for the expression of type I and type II TGF-beta receptors . Eighteen tumor and 20 normal samples were used for radioactive thermocycling and sequencing of the two microsatellite-like regions of the type II rec...
9609758	[ "##", "RESULTS" ]	[ 0, 0 ]	## RESULTS
9609758	[ "Both", "receptors", "were", "overexpressed", "in", "tumors", "compared", "with", "normal", "samples.", "There", "was", "a", "relationship", "between", "the", "abundance", "of", "type", "II", "receptor", "expression", "and", "the", "degree", "of", "differentiation...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Both receptors were overexpressed in tumors compared with normal samples. There was a relationship between the abundance of type II receptor expression and the degree of differentiation of the tumors but not the Dukes' staging or the localization of the neoplasias. No mutation was observed in the microsatellite-like re...
9609758	[ "##", "CONCLUSIONS" ]	[ 0, 0 ]	## CONCLUSIONS
9609758	[ "Sporadic", "colorectal", "cancers", "do", "not", "show", "an", "absence", "or", "a", "presence", "of", "mutated", "TGF-beta", "receptors", "that", "could", "explain", "a", "resistance", "to", "TGF-beta-mediated", "growth", "inhibition.", "The", "pathways", "to", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Sporadic colorectal cancers do not show an absence or a presence of mutated TGF-beta receptors that could explain a resistance to TGF-beta-mediated growth inhibition. The pathways to tumorigenesis of sporadic colorectal cancers may be different from those of some hereditary ones.

25374237

[ "Individuals", "with", "-31C", "allele", "and", "CC", "genotype", "were", "found", "to", "have", "a", "higher", "risk", "of", "developing", "colon", "cancer", "(OR=13.4,", "p=0.01).", "The", "-241", "CT", "genotype", "considerably", "increased", "the", "risk", ...

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Individuals with -31C allele and CC genotype were found to have a higher risk of developing colon cancer (OR=13.4, p=0.01). The -241 CT genotype considerably increased the risk of colon cancer (OR=12.0, p=0.0001). However, there was no significant varaition of the survivin -625 C/G polymorphism survivin polymorphisms ...

25374237

[ "##", "MATERIALS", "AND", "METHODS" ]

[ 0, 0, 0, 0 ]

## MATERIALS AND METHODS

25374237

[ "The", "relation", "between", "colon", "cancer", "and", "survivin", "-31", "G/C", "(rs9904341),", "-241", "C/T", "(rs17878467)", "and", "-625", "C/G", "(rs8073069)", "polymorphism", "in", "promotor", "site", "of", "survivin", "gene", "associated", "with", "apoptos...

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The relation between colon cancer and survivin -31 G/C (rs9904341), -241 C/T (rs17878467) and -625 C/G (rs8073069) polymorphism in promotor site of survivin gene associated with apoptosis was investigated using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.

25374237

[ "##", "RESULTS" ]

[ 0, 0 ]

## RESULTS

25374237

[ "Individuals", "with", "-31C", "allele", "and", "CC", "genotype", "were", "found", "to", "have", "a", "higher", "risk", "of", "developing", "colon", "cancer", "(OR=13.4,", "p=0.01).", "The", "-241", "CT", "genotype", "considerably", "increased", "the", "risk", ...

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Individuals with -31C allele and CC genotype were found to have a higher risk of developing colon cancer (OR=13.4, p=0.01). The -241 CT genotype considerably increased the risk of colon cancer (OR=12.0, p=0.0001). However, there was no significant varaition of the survivin -625 C/G polymorphism among colon cancer patie...

25374237

[ "##", "CONCLUSIONS" ]

[ 0, 0 ]

## CONCLUSIONS

25374237

[ "This", "study", "provides", "the", "first", "evidence", "that", "survivin", "-31", "G/C", "and", "-241", "C/T", "SNP", "significantly", "contribute", "to", "the", "risk", "of", "colon", "cancer", "in", "the", "Turkish", "population." ]

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This study provides the first evidence that survivin -31 G/C and -241 C/T SNP significantly contribute to the risk of colon cancer in the Turkish population.

25374237

[]

24196785

[ "Amplification", "of", "PVT-1", "is", "involved", "in", "poor", "prognosis", "via", "apoptosis", "inhibition", "in", "colorectal", "cancers.", "\n\n\n", "##", "BACKGROUND" ]

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Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers. ## BACKGROUND

24196785

[ "We", "previously", "conducted", "gene", "expression", "microarray", "analyses", "to", "identify", "novel", "indicators", "for", "colorectal", "cancer", "(CRC)", "metastasis", "and", "prognosis", "from", "which", "we", "identified", "PVT-1", "as", "a", "candidate", ...

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We previously conducted gene expression microarray analyses to identify novel indicators for colorectal cancer (CRC) metastasis and prognosis from which we identified PVT-1 as a candidate gene. PVT-1, which encodes a long noncoding RNA, mapped to chromosome 8q24 whose copy-number amplification is one of the most freque...

24196785

[ "##", "METHODS" ]

[ 0, 0 ]

## METHODS

24196785

[ "We", "conducted", "cell", "proliferation", "and", "invasion", "assays", "using", "colorectal", "cancer", "cell", "lines", "transfected", "with", "PVT-1siRNA", "or", "negative", "control", "siRNA.", "Gene", "expression", "microarray", "analyses", "on", "these", "cel...

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We conducted cell proliferation and invasion assays using colorectal cancer cell lines transfected with PVT-1siRNA or negative control siRNA. Gene expression microarray analyses on these cell lines were also carried out to investigate the molecular function of PVT-1. Further, we investigated the impact of PVT-1 expre...

24196785

[ "##", "RESULTS" ]

[ 0, 0 ]

## RESULTS

24196785

[ "CRC", "cells", "transfected", "with", "PVT-1", " ", "siRNA", "exhibited", "significant", "loss", "of", "their", "proliferation", "and", "invasion", "capabilities.", "In", "these", "cells,", "the", "TGF-β", "signalling", "pathway", "and", "apoptotic", "signals", "...

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CRC cells transfected with PVT-1 siRNA exhibited significant loss of their proliferation and invasion capabilities. In these cells, the TGF-β signalling pathway and apoptotic signals were significantly activated. In addition, univariate and multivariate analysis revealed that PVT-1 TGF-β signalling pathway and apop...

24196785

[ "##", "CONCLUSION" ]

[ 0, 0 ]

## CONCLUSION

24196785

[ "PVT-1,", "which", "maps", "to", "8q24", "PVT-1", ",", "which", "maps", "to", "8q24,", "generates", "antiapoptotic", "activity", "in", "CRC,", "and", "abnormal", "expression", "of", "PVT-1", "PVT-1", "PVT-1", " ", "is", "involved", "in", "poor", "prognosis", ...

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PVT-1, which maps to 8q24 PVT-1 , which maps to 8q24, generates antiapoptotic activity in CRC, and abnormal expression of PVT-1 PVT-1 PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers. ## BACKGROUND

24196785

[ "We", "previously", "conducted", "gene", "expression", "microarray", "analyses", "to", "identify", "novel", "indicators", "for", "colorectal", "cancer", "(CRC)", "metastasis", "and", "prognosis", "from", "which", "we", "identified", "PVT-1", "as", "a", "candidate", ...

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We previously conducted gene expression microarray analyses to identify novel indicators for colorectal cancer (CRC) metastasis and prognosis from which we identified PVT-1 as a candidate gene. PVT-1 , which encodes a long noncoding RNA, mapped to chromosome 8q24 whose copy-number amplification is one of the most fre...

24196785

[ "##", "METHODS" ]

[ 0, 0 ]

## METHODS

24196785

[ "We", "conducted", "cell", "proliferation", "and", "invasion", "assays", "using", "colorectal", "cancer", "cell", "lines", "transfected", "with", "PVT-1", "Amplification", " ", "of", "PVT-1", "is", "involved", "in", "poor", "prognosis", "via", "apoptosis", "inhibi...

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We conducted cell proliferation and invasion assays using colorectal cancer cell lines transfected with PVT-1 Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers. ## BACKGROUND

24196785

[ "We", "previously", "conducted", "gene", "expression", "microarray", "analyses", "to", "identify", "novel", "indicators", "for", "colorectal", "cancer", "(CRC)", "metastasis", "and", "prognosis", "from", "which", "we", "identified", "PVT-1", "as", "a", "candidate", ...

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We previously conducted gene expression microarray analyses to identify novel indicators for colorectal cancer (CRC) metastasis and prognosis from which we identified PVT-1 as a candidate gene. PVT-1, which encodes a long noncoding RNA, mapped to chromosome 8q24 whose copy-number amplification is one of the most freq...

24196785

[ "##", "METHODS" ]

[ 0, 0 ]

## METHODS

24196785

[ "We", "conducted", "cell", "proliferation", "and", "invasion", "assays", "using", "colorectal", "cancer", "cell", "lines", "transfected", "with", "PVT-1siRNA", "or", "negative", "control", "siRNA.", "Gene", "expression", "microarray", "analyses", "on", "these", "cel...

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We conducted cell proliferation and invasion assays using colorectal cancer cell lines transfected with PVT-1siRNA or negative control siRNA. Gene expression microarray analyses on these cell lines were also carried out to investigate the molecular function of PVT-1 . Further, we investigated the impact of PVT-1 expres...

24196785

[ "##", "RESULTS" ]

[ 0, 0 ]

## RESULTS

24196785

[ "CRC", "cells", "transfected", "with", "PVT-1", "siRNA", "exhibited", "significant", "loss", "of", "their", "proliferation", "and", "invasion", "capabilities.", "In", "these", "cells,", "the", "TGF-β", "signalling", "pathway", "and", "apoptotic", "signals", "were", ...

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CRC cells transfected with PVT-1 siRNA exhibited significant loss of their proliferation and invasion capabilities. In these cells, the TGF-β signalling pathway and apoptotic signals were significantly activated. In addition, univariate and multivariate analysis revealed that PVT-1 expression level was an independent r...

24196785

[ "##", "CONCLUSION" ]

[ 0, 0 ]

## CONCLUSION

24196785

[ "PVT-1,", "which", "maps", "to", "8q24,", "generates", "antiapoptotic", "activity", "in", "CRC,", "and", "abnormal", "expression", "of", "PVT-1", "was", "a", "prognostic", "indicator", "for", "CRC", "patients." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

PVT-1, which maps to 8q24, generates antiapoptotic activity in CRC, and abnormal expression of PVT-1 was a prognostic indicator for CRC patients.

24196785

[]

1299227

[ "Colorectal", "carcinoma.", "DNA", "ploidy", "pattern", "and", "prognosis", "with", "reference", "to", "tumor", "DNA", "heterogeneity." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

Colorectal carcinoma. DNA ploidy pattern and prognosis with reference to tumor DNA heterogeneity.

1299227

[ "Nuclear", "DNA", "content", "was", "measured", "in", "72", "colorectal", "carcinomas", "using", "single-cell", "microspectrophotometry", "on", "Feulgen-stained", "smears.", "Four", "samples", "were", "analyzed", "from", "each", "tumor.", "Patients", "were", "followed...

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Nuclear DNA content was measured in 72 colorectal carcinomas using single-cell microspectrophotometry on Feulgen-stained smears. Four samples were analyzed from each tumor. Patients were followed for 41-65 months (average, 53). DNA heterogeneity (both aneuploid and nonaneuploid patterns) was present in 44% of the cases...

1299227

[ "Nuclear", "DNA", "content", "was", "measured", "in", "72", "colorectal", "carcinomas", "using", "single-cell", "microspectrophotometry", "on", "Feulgen-stained", "smears.", "Four", "samples", "were", "analyzed", "from", "each", "tumor.", "Patients", "were", "followed...

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Nuclear DNA content was measured in 72 colorectal carcinomas using single-cell microspectrophotometry on Feulgen-stained smears. Four samples were analyzed from each tumor. Patients were followed for 41-65 months (average, 53). DNA heterogeneity (both aneuploid and nonaneuploid patterns) was present in 44% of the cases...

1299227

[]

26302849

[ "Polymorphisms", "of", "PRLHR", "and", "HSPA12A", "and", "risk", "of", "gastric", "and", "colorectal", "cancer", "in", "the", "Chinese", "Han", "population.", "\n\n\n", "##", "BACKGROUND" ]

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Polymorphisms of PRLHR and HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population. ## BACKGROUND

26302849

[ "Gastric", "and", "colorectal", "cancers", "have", "a", "major", "impact", "on", "public", "health,", "and", "are", "the", "most", "common", "malignant", "tumors", "in", "China.", "The", "aim", "of", "this", "research", "was", "to", "study", "whether", "poly...

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Gastric and colorectal cancers have a major impact on public health, and are the most common malignant tumors in China. The aim of this research was to study whether polymorphisms of CHCHD3P1-HSP90AB7P, GRID1, HSPA12A, PRLHR, SBF2, POLD3 and C11orf93-C11orf92 genes are associated with the risk of gastric and colorectal...

26302849

[ "##", "METHODS" ]

[ 0, 0 ]

## METHODS

26302849

[ "We", "genotyped", "seven", "single", "nucleotide", "polymorphisms", " ", "(SNPs)", "from", "seven", "genes.", "We", "selected", "588", "patients", "with", "gastric", "cancer", "and", "449", "with", "colorectal", "cancer,", "along", "with", "703", "healthy", "co...

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We genotyped seven single nucleotide polymorphisms (SNPs) from seven genes. We selected 588 patients with gastric cancer and 449 with colorectal cancer, along with 703 healthy controls. All these SNPs were evaluated using the χ² test and genetic model analysis.

26302849

[ "##", "RESULTS" ]

[ 0, 0 ]

## RESULTS

26302849

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The genotype "A/T" of rs12413624 in PRLHR gene was associated with a decreased risk of colorectal cancer in allele model analysis [odds ratio (OR) = 0.81; 95% confidence interval (CI) = 0.68-0.97; p = 0.018] and log-additive model analysis (OR = 0.81; 95% CI = 0.66-0.98; p = 0.032). The genotype...

26302849

[ "##", "CONCLUSIONS" ]

[ 0, 0 ]

## CONCLUSIONS

26302849

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Our results provide evidence that variants of PRLHR gene are a protective factor in colorectal cancer and variants C11orf93-C11orf92 genes are associated with the risk of gastric and colorectal cancers in the Chinese Han population.

26302849

[ "##", "METHODS" ]

[ 0, 0 ]

## METHODS

26302849

[ "We", "genotyped", "seven", "single", "nucleotide", "polymorphisms", "(", "SNPs", ")", "from", "seven", "genes.", "We", "selected", "588", "patients", "with", "gastric", "cancer", "and", "449", "with", "colorectal", "cancer,", "along", "with", "703", "healthy", ...

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We genotyped seven single nucleotide polymorphisms ( SNPs ) from seven genes. We selected 588 patients with gastric cancer and 449 with colorectal cancer, along with 703 healthy controls. All these SNPs Polymorphisms of PRLHR and HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population. ## ...

26302849

[ "Gastric", "and", "colorectal", "cancers", "have", "a", "major", "impact", "on", "public", "health,", "and", "are", "the", "most", "common", "malignant", "tumors", "in", "China.", "The", "aim", "of", "this", "research", "was", "to", "study", "whether", "poly...

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Gastric and colorectal cancers have a major impact on public health, and are the most common malignant tumors in China. The aim of this research was to study whether polymorphisms of CHCHD3P1-HSP90AB7P, GRID1 , HSPA12A , PRLHR , SBF2 , POLD3 and C11orf93-C11orf92 genes are associated with the risk of gastric and colo...

26302849

[ "##", "METHODS" ]

[ 0, 0 ]

## METHODS

26302849

[ "We", "genotyped", "seven", "single", "nucleotide", "polymorphisms", "(SNPs)", "from", "seven", "genes.", "We", "selected", "588", "patients", "with", "gastric", "cancer", "and", "449", "with", "colorectal", "cancer,", "along", "with", "703", "healthy", "controls....

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We genotyped seven single nucleotide polymorphisms (SNPs) from seven genes. We selected 588 patients with gastric cancer and 449 with colorectal cancer, along with 703 healthy controls. All these SNPs were evaluated using the χ² test and genetic model analysis.

26302849

[ "##", "RESULTS" ]

[ 0, 0 ]

## RESULTS

26302849

[ "The", "genotype", "\"A/T\"", "of", "rs12413624", " ", "in", "PRLHR", "gene", "was", "associated", "with", "a", "decreased", "risk", "of", "colorectal", "cancer", "in", "allele", "model", "analysis", "[odds", "ratio", "(OR)", " ", "=", " ", "0.81;", "95%", ...

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The genotype "A/T" of rs12413624 in PRLHR gene was associated with a decreased risk of colorectal cancer in allele model analysis [odds ratio (OR) = 0.81; 95% confidence interval (CI) = 0.68-0.97; p = 0.018] and log-additive model analysis (OR = 0.81; 95% CI = 0.66-0.98; p = 0.032). The genoty...

26302849

[ "##", "CONCLUSIONS" ]

[ 0, 0 ]

## CONCLUSIONS

26302849

[ "Our", "results", "provide", "evidence", "that", "variants", "of", "PRLHR", "HSPA12A", "PRLHR", " ", "and", "HSPA12A", "and", "risk", "of", "gastric", "and", "colorectal", "cancer", "in", "the", "Chinese", "Han", "population.", "\n\n\n", "##", "BACKGROUND" ]

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Our results provide evidence that variants of PRLHR HSPA12A PRLHR and HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population. ## BACKGROUND

26302849

[ "Gastric", "and", "colorectal", "cancers", "have", "a", "major", "impact", "on", "public", "health,", "and", "are", "the", "most", "common", "malignant", "tumors", "in", "China.", "The", "aim", "of", "this", "research", "was", "to", "study", "whether", "poly...

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Gastric and colorectal cancers have a major impact on public health, and are the most common malignant tumors in China. The aim of this research was to study whether polymorphisms of CHCHD3P1-HSP90AB7P, GRID1, HSPA12A, PRLHR, SBF2, POLD3 and C11orf93-C11orf92 genes are associated with the risk of gastric and colorectal...

26302849

[ "##", "METHODS" ]

[ 0, 0 ]

## METHODS

26302849

[ "We", "genotyped", "seven", "single", "nucleotide", "polymorphisms", "(SNPs)", "from", "seven", "genes.", "We", "selected", "588", "patients", "with", "gastric", "cancer", "and", "449", "with", "colorectal", "cancer,", "along", "with", "703", "healthy", "controls....

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

We genotyped seven single nucleotide polymorphisms (SNPs) from seven genes. We selected 588 patients with gastric cancer and 449 with colorectal cancer, along with 703 healthy controls. All these SNPs were evaluated using the χ² test and genetic model analysis.

26302849

[ "##", "RESULTS" ]

[ 0, 0 ]

## RESULTS

26302849

[ "The", "genotype", "\"A/T\"", "of", "rs12413624", "in", "PRLHR", "gene", "was", "associated", "with", "a", "decreased", "risk", "of", "colorectal", "cancer", "in", "allele", "model", "analysis", "[odds", "ratio", "(OR)", " ", "=", " ", "0.81;", "95%", "confi...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...

The genotype "A/T" of rs12413624 in PRLHR gene was associated with a decreased risk of colorectal cancer in allele model analysis [odds ratio (OR) = 0.81; 95% confidence interval (CI) = 0.68-0.97; p = 0.018] and log-additive model analysis (OR = 0.81; 95% CI = 0.66-0.98; p = 0.032). The genotype...

26302849

[ "##", "CONCLUSIONS" ]

[ 0, 0 ]

## CONCLUSIONS

26302849

[ "Our", "results", "provide", "evidence", "that", "variants", "of", "PRLHR", "gene", "are", "a", "protective", "factor", "in", "colorectal", "cancer", "and", "variants", "of", "HSPA12A", "HSPA12A", " ", "and", "risk", "of", "gastric", "and", "colorectal", "canc...

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Our results provide evidence that variants of PRLHR gene are a protective factor in colorectal cancer and variants of HSPA12A HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population. ## BACKGROUND

26302849

[ "Gastric", "and", "colorectal", "cancers", "have", "a", "major", "impact", "on", "public", "health,", "and", "are", "the", "most", "common", "malignant", "tumors", "in", "China.", "The", "aim", "of", "this", "research", "was", "to", "study", "whether", "poly...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

Gastric and colorectal cancers have a major impact on public health, and are the most common malignant tumors in China. The aim of this research was to study whether polymorphisms of CHCHD3P1-HSP90AB7P , GRID1, HSPA12A, PRLHR, SBF2, POLD3 and C11orf93-C11orf92 genes are associated with the risk of gastric and colorec...

26302849

[ "##", "METHODS" ]

[ 0, 0 ]

## METHODS

26302849

[ "We", "genotyped", "seven", "single", "nucleotide", "polymorphisms", "(SNPs)", "from", "seven", "genes.", "We", "selected", "588", "patients", "with", "gastric", "cancer", "and", "449", "with", "colorectal", "cancer,", "along", "with", "703", "healthy", "controls....

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

We genotyped seven single nucleotide polymorphisms (SNPs) from seven genes. We selected 588 patients with gastric cancer and 449 with colorectal cancer, along with 703 healthy controls. All these SNPs were evaluated using the χ² test and genetic model analysis.

26302849

[ "##", "RESULTS" ]

[ 0, 0 ]

## RESULTS

26302849

[ "The", "genotype", "\"A/T\"", "of", "rs12413624", "in", "PRLHR", "gene", "was", "associated", "with", "a", "decreased", "risk", "of", "colorectal", "cancer", "in", "allele", "model", "analysis", "[odds", "ratio", "(OR)", " ", "=", " ", "0.81;", "95%", "confi...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...

The genotype "A/T" of rs12413624 in PRLHR gene was associated with a decreased risk of colorectal cancer in allele model analysis [odds ratio (OR) = 0.81; 95% confidence interval (CI) = 0.68-0.97; p = 0.018] and log-additive model analysis (OR = 0.81; 95% CI = 0.66-0.98; p = 0.032). The genotype...

26302849

[ "##", "CONCLUSIONS" ]

[ 0, 0 ]

## CONCLUSIONS

26302849

[ "Our", "results", "provide", "evidence", "that", "variants", "of", "PRLHR", "gene", "are", "a", "protective", "factor", "in", "colorectal", "cancer", "and", "variants", "of", "HSPA12A", "gene", "are", "a", "protective", "factor", "in", "gastric", "cancer", "in...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

Our results provide evidence that variants of PRLHR gene are a protective factor in colorectal cancer and variants of HSPA12A gene are a protective factor in gastric cancer in the Chinese Han population.

26302849

[]

26710976

[ "Mismatch", "repair", "defects", "and", "Lynch", "syndrome:", "The", "role", "of", "the", "basic", "scientist", "in", "the", "battle", "against", "cancer." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

Mismatch repair defects and Lynch syndrome: The role of the basic scientist in the battle against cancer.

26710976

[ "We", "have", "currently", "entered", "a", "genomic", "era", "of", "cancer", "research", "which", "may", "soon", "lead", "to", "a", "genomic", "era", "of", "cancer", "treatment.", "Patient", "DNA", "sequencing", "information", "may", "lead", "to", "a", "pers...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...

We have currently entered a genomic era of cancer research which may soon lead to a genomic era of cancer treatment. Patient DNA sequencing information may lead to a personalized approach to managing an individual's cancer as well as future cancer risk. The success of this approach, however, begins not necessarily in t...

26710976

[]

18097606

[ "Transcriptional", "regulation", "of", "the", "COX-2", "expression", "by", "nitric", "oxide", "in", "colon", "cancer", "cell", "lines." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

Transcriptional regulation of the COX-2 expression by nitric oxide in colon cancer cell lines.

18097606

[ "To", "determine", "the", "effect", "of", "nitric", "oxide", "(NO)", "on", "the", "cyclooxygenase-2", "(COX-2)", "regulation", "in", "colon", "cancer", "cell", "lines", "we", "used", "the", "physiological", "NO", "donor", "GSNO.", "The", "proximal", "6.6", "kb...

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To determine the effect of nitric oxide (NO) on the cyclooxygenase-2 (COX-2) regulation in colon cancer cell lines we used the physiological NO donor GSNO. The proximal 6.6 kb of the COX-2 promoter was cloned into the pGL3 basic vector and the sequential deletion of the 6.6 kb promoter was cloned into the pGL3 basic ...

18097606

[ "To", "determine", "the", "effect", "of", "nitric", "oxide", "(NO)", "on", "the", "cyclooxygenase-2", "(", "COX-2", "cyclooxygenase-2", " ", "(COX-2)", "regulation", "in", "colon", "cancer", "cell", "lines", "we", "used", "the", "physiological", "NO", "donor", ...

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To determine the effect of nitric oxide (NO) on the cyclooxygenase-2 ( COX-2 cyclooxygenase-2 (COX-2) regulation in colon cancer cell lines we used the physiological NO donor GSNO. The proximal 6.6 kb of the COX-2 promoter was cloned into the pGL3 basic vector and the sequential deletion of the 6.6 kb COX-2 promoter ...

18097606

[]

17007003

[ "Collision", "tumor", "of", "the", "rectum:", "a", "case", "report", "of", "metastatic", "gastric", "adenocarcinoma", "plus", "primary", "rectal", "adenocarcinoma." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

Collision tumor of the rectum: a case report of metastatic gastric adenocarcinoma plus primary rectal adenocarcinoma.

17007003

[ "Collision", "tumors", "are", "thought", "to", "arise", "from", "the", "accidental", "meeting", "and", "interpenetration", "of", "two", "independent", "tumors.", "We", "report", "here", "a", "highly", "unusual", "case", "of", "a", "61-year", "old", "man", "who...

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Collision tumors are thought to arise from the accidental meeting and interpenetration of two independent tumors. We report here a highly unusual case of a 61-year old man who had a unique tumor that was composed of a metastatic adenocarcinoma from the stomach to the rectum, which harbored a collision tumor of primary ...

17007003

[]

12000733

[ "CpG", "island", "methylation", "in", "aberrant", "crypt", "foci", "of", "the", "colorectum." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

CpG island methylation in aberrant crypt foci of the colorectum.

12000733

[ "Aberrant", "crypt", "foci", "(ACF)", "are", "postulated", "to", "be", "the", "earliest", "precursor", "lesion", "in", "colorectal", "carcinogenesis,", "and", "CpG", "island", "methylation", "has", "been", "described", "as", "an", "important", "molecular", "pathwa...

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Aberrant crypt foci (ACF) are postulated to be the earliest precursor lesion in colorectal carcinogenesis, and CpG island methylation has been described as an important molecular pathway. We therefore studied methylation in ACF from patients with familial adenomatous polyposis (FAP) or sporadic colorectal cancer. We as...

12000733

[ "Aberrant", "crypt", "foci", "(ACF)", "are", "postulated", "to", "be", "the", "earliest", "precursor", "lesion", "in", "colorectal", "carcinogenesis,", "and", "CpG", "island", "methylation", "CpG", "island", " ", "methylation", "has", "been", "described", "as", ...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2...

Aberrant crypt foci (ACF) are postulated to be the earliest precursor lesion in colorectal carcinogenesis, and CpG island methylation CpG island methylation has been described as an important molecular pathway. We therefore studied methylation in ACF from patients with familial adenomatous polyposis (FAP) or sporadic...

12000733

[]

9609758

[ "Expression", "of", "transforming", "growth", "factor", "beta", "receptors", "in", "normal", "human", "colon", "and", "sporadic", "adenocarcinomas.", "\n\n\n", "##", "BACKGROUND", "&", "AIMS" ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

Expression of transforming growth factor beta receptors in normal human colon and sporadic adenocarcinomas. ## BACKGROUND & AIMS

9609758

[ "An", "absence", "or", "a", "presence", "of", "mutated", "transforming", "growth", "factor", " ", "(TGF)-beta", "receptors", "is", "a", "possible", "hypothesis", "explaining", "the", "resistance", "of", "cancer", "cells", "to", "the", "growth-inhibitory", "effect"...

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An absence or a presence of mutated transforming growth factor (TGF)-beta receptors is a possible hypothesis explaining the resistance of cancer cells to the growth-inhibitory effect of TGF-beta. Mutations involving microsatellite-like regions of the type II TGF-beta receptor have been described in subgroups of color...

9609758

[ "##", "METHODS" ]

[ 0, 0 ]

## METHODS

9609758

[ "Thirty-three", "sporadic", "colorectal", "cancers", "and", "20", "normal", "colonic", "tissues", "were", "explored", "by", "immunohistochemistry", "for", "the", "expression", "of", "type", "I", "and", "type", "II", "TGF-beta", "receptors.", "Eighteen", "tumor", "...

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Thirty-three sporadic colorectal cancers and 20 normal colonic tissues were explored by immunohistochemistry for the expression of type I and type II TGF-beta receptors. Eighteen tumor and 20 normal samples were used for radioactive thermocycling and sequencing of the two microsatellite-like regions of the type II rece...

9609758

[ "##", "RESULTS" ]

[ 0, 0 ]

## RESULTS

9609758

[ "Both", "receptors", "were", "overexpressed", "in", "tumors", "compared", "with", "normal", "samples.", "There", "was", "a", "relationship", "between", "the", "abundance", "of", "type", "II", "receptor", "expression", "and", "the", "degree", "of", "differentiation...

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Both receptors were overexpressed in tumors compared with normal samples. There was a relationship between the abundance of type II receptor expression and the degree of differentiation of the tumors but not the Dukes' staging or the localization of the neoplasias. No mutation was observed in the microsatellite-like re...

9609758

[ "##", "METHODS" ]

[ 0, 0 ]

## METHODS

9609758

[ "Thirty-three", "sporadic", "colorectal", "cancers", "and", "20", "normal", "colonic", "tissues", "were", "explored", "by", "immunohistochemistry", "for", "the", "expression", "of", "type", "I", "and", "type", "II", "TGF-beta", "receptors.", "Eighteen", "tumor", "...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

Thirty-three sporadic colorectal cancers and 20 normal colonic tissues were explored by immunohistochemistry for the expression of type I and type II TGF-beta receptors. Eighteen tumor and 20 normal samples were used for radioactive thermocycling and sequencing of the two microsatellite-like regions of the type II rece...

9609758

[ "##", "RESULTS" ]

[ 0, 0 ]

## RESULTS

9609758

[ "Both", "receptors", "were", "overexpressed", "in", "tumors", "compared", "with", "normal", "samples.", "There", "was", "a", "relationship", "between", "the", "abundance", "of", "type", "II", "receptor", "type", "II", "receptor", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 1, 2, 2, 0 ]

Both receptors were overexpressed in tumors compared with normal samples. There was a relationship between the abundance of type II receptor type II receptor .

9609758

[ "##", "RESULTS" ]

[ 0, 0 ]

## RESULTS

9609758

[ "Both", "receptors", "were", "overexpressed", "in", "tumors", "compared", "with", "normal", "samples.", "There", "was", "a", "relationship", "between", "the", "abundance", "of", "type", "II", "receptor", "expression", "and", "the", "degree", "of", "differentiation...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

Both receptors were overexpressed in tumors compared with normal samples. There was a relationship between the abundance of type II receptor expression and the degree of differentiation of the tumors but not the Dukes' staging or the localization of the neoplasias. No mutation was observed in the microsatellite-like re...

9609758

[ "##", "CONCLUSIONS" ]

[ 0, 0 ]

## CONCLUSIONS

9609758

[ "Sporadic", "colorectal", "cancers", "do", "not", "show", "an", "absence", "or", "a", "presence", "of", "mutated", "TGF-beta", "receptors", "mutation", " ", "was", "observed", "in", "the", "microsatellite-like", "regions", "of", "receptor", "II", "in", "any", ...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

Sporadic colorectal cancers do not show an absence or a presence of mutated TGF-beta receptors mutation was observed in the microsatellite-like regions of receptor II in any of the samples.

9609758

[ "##", "CONCLUSIONS" ]

[ 0, 0 ]

## CONCLUSIONS

9609758

[ "Sporadic", "colorectal", "cancers", "do", "not", "show", "an", "absence", "or", "a", "presence", "of", "mutated", "TGF-beta", "receptors", "that", "could", "explain", "a", "resistance", "to", "TGF-beta", "mutated", "transforming", "growth", "factor", "beta", "r...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 3, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

Sporadic colorectal cancers do not show an absence or a presence of mutated TGF-beta receptors that could explain a resistance to TGF-beta mutated transforming growth factor beta receptors in normal human colon and sporadic adenocarcinomas. ## BACKGROUND & AIMS

9609758

[ "An", "absence", "or", "a", "presence", "of", "mutated", "transforming", "growth", "factor", "(TGF)-beta", "receptors", "is", "a", "possible", "hypothesis", "explaining", "the", "resistance", "of", "cancer", "cells", "to", "the", "growth-inhibitory", "effect", "of...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...

An absence or a presence of mutated transforming growth factor (TGF)-beta receptors is a possible hypothesis explaining the resistance of cancer cells to the growth-inhibitory effect of TGF-beta mutated transforming growth factor (TGF)-beta receptors is a possible hypothesis explaining the resistance of cancer cells ...

9609758

[ "##", "METHODS" ]

[ 0, 0 ]

## METHODS

9609758

[ "Thirty-three", "sporadic", "colorectal", "cancers", "and", "20", "normal", "colonic", "tissues", "were", "explored", "by", "immunohistochemistry", "for", "the", "expression", "of", "type", "I", "and", "type", "II", "TGF-beta", "receptors", ".", "Eighteen", "tumor...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

Thirty-three sporadic colorectal cancers and 20 normal colonic tissues were explored by immunohistochemistry for the expression of type I and type II TGF-beta receptors . Eighteen tumor and 20 normal samples were used for radioactive thermocycling and sequencing of the two microsatellite-like regions of the type II rec...

9609758

[ "##", "RESULTS" ]

[ 0, 0 ]

## RESULTS

9609758

[ "Both", "receptors", "were", "overexpressed", "in", "tumors", "compared", "with", "normal", "samples.", "There", "was", "a", "relationship", "between", "the", "abundance", "of", "type", "II", "receptor", "expression", "and", "the", "degree", "of", "differentiation...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

Both receptors were overexpressed in tumors compared with normal samples. There was a relationship between the abundance of type II receptor expression and the degree of differentiation of the tumors but not the Dukes' staging or the localization of the neoplasias. No mutation was observed in the microsatellite-like re...

9609758

[ "##", "CONCLUSIONS" ]

[ 0, 0 ]

## CONCLUSIONS

9609758

[ "Sporadic", "colorectal", "cancers", "do", "not", "show", "an", "absence", "or", "a", "presence", "of", "mutated", "TGF-beta", "receptors", "that", "could", "explain", "a", "resistance", "to", "TGF-beta-mediated", "growth", "inhibition.", "The", "pathways", "to", ...

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Sporadic colorectal cancers do not show an absence or a presence of mutated TGF-beta receptors that could explain a resistance to TGF-beta-mediated growth inhibition. The pathways to tumorigenesis of sporadic colorectal cancers may be different from those of some hereditary ones.