Brizape/amia_split_0404 · Datasets at Hugging Face

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9609758	[]	[]
7557155	[ "DNA", "mismatch", "repair", "and", "cancer." ]	[ 0, 0, 0, 0, 0 ]	DNA mismatch repair and cancer.
7557155	[ "The", "genetic", "basis", "of", "cancer", "involves", "certain", "classes", "of", "genes,", "particularly", "oncogenes,", "tumor-suppressor", "genes,", "and", "DNA", "mismatch", "repair", "genes.", "Originally", "identified", "in", "bacteria", "and", "yeast,", "the...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	The genetic basis of cancer involves certain classes of genes, particularly oncogenes, tumor-suppressor genes, and DNA mismatch repair genes. Originally identified in bacteria and yeast, the human homologues of DNA mismatch repair genes have been implicated in the pathogenesis of the hereditary nonpolyposis colorectal ...
7557155	[]	[]
18184403	[ "Expression", "of", "beclin-1,", "an", "autophagy-related", "protein,", "in", "gastric", "and", "colorectal", "cancers." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers.
18184403	[ "Autophagy", "plays", "important", "roles", "in", "both", "cell", "death", "and", "cell", "survival.", "Beclin-1,", "a", "key", "regulator", "of", "autophagy", "formation,", "has", "been", "considered", "as", "a", "haploinsufficient", "tumor", "suppressor.", "Loss...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	Autophagy plays important roles in both cell death and cell survival. Beclin-1, a key regulator of autophagy formation, has been considered as a haploinsufficient tumor suppressor. Loss of expression or point mutation could serve as a mechanism of loss of beclin-1 tumor suppressor function in cancers. However, our rece...
18184403	[ "Autophagy", "plays", "important", "roles", "in", "both", "cell", "death", "and", "cell", "survival.", "Beclin-1,", "a", "key", "regulator", "of", "autophagy", "formation,", "has", "been", "considered", "as", "a", "haploinsufficient", "tumor", "suppressor.", "Loss...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	Autophagy plays important roles in both cell death and cell survival. Beclin-1, a key regulator of autophagy formation, has been considered as a haploinsufficient tumor suppressor. Loss of expression or point mutation Beclin-1 , a key regulator of autophagy formation, has been considered as a haploinsufficient tumor su...
18184403	[]	[]
22810479	[ "Is", "K-ras", "gene", "mutation", "a", "prognostic", "factor", "for", "colorectal", "cancer:", "a", "systematic", "review", "and", "meta-analysis.", "\n\n\n", "##", "BACKGROUND" ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Is K-ras gene mutation a prognostic factor for colorectal cancer: a systematic review and meta-analysis. ## BACKGROUND
22810479	[ ":", "The", "K-ras", "gene", "is", "one", "of", "the", "commonly", "mutated", "oncogenes", "associated", "with", "colorectal", "cancer.", "However,", "its", "prognostic", "significance", "for", "patients", "with", "colorectal", "cancer", "remains", "inconclusive." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	: The K-ras gene is one of the commonly mutated oncogenes associated with colorectal cancer. However, its prognostic significance for patients with colorectal cancer remains inconclusive.
22810479	[ "##", "OBJECTIVE" ]	[ 0, 0 ]	## OBJECTIVE
22810479	[ ":", "To", "derive", "a", "more", "precise", "estimation", "of", "the", "prognostic", "significance", "of", "K-ras", "gene", "mutations,", "a", "systematic", "review", "and", "meta-analysis", "were", "performed." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	: To derive a more precise estimation of the prognostic significance of K-ras gene mutations, a systematic review and meta-analysis were performed.
22810479	[ "##", "DATA", "SOURCES" ]	[ 0, 0, 0 ]	## DATA SOURCES
22810479	[ ":", "We", "searched", "PubMed,", "Embase,", "and", "the", "Cochrane", "databases", "from", "January", "1992", "to", "November", "2011." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	: We searched PubMed, Embase, and the Cochrane databases from January 1992 to November 2011.
22810479	[ "##", "STUDY", "SELECTION" ]	[ 0, 0, 0 ]	## STUDY SELECTION
22810479	[ ":", "The", "prognostic", "value", "of", "K-ras", " ", "gene", "mutations", " ", "was", "examined", "in", "patients", "with", "colorectal", "cancer", "who", "did", "not", "receive", "preoperative", "chemotherapy", "or", "radiation." ]	[ 0, 0, 0, 0, 0, 1, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	: The prognostic value of K-ras gene mutations was examined in patients with colorectal cancer who did not receive preoperative chemotherapy or radiation.
22810479	[ "##", "MAIN", "OUTCOME", "MEASURES" ]	[ 0, 0, 0, 0 ]	## MAIN OUTCOME MEASURES
22810479	[ ":", "The", "effect", "of", "K-ras", " ", "gene", "mutations", " ", "on", "the", "overall", "survival", "was", "measured", "by", "the", "HR", "and", "95%", "CIs." ]	[ 0, 0, 0, 0, 1, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	: The effect of K-ras gene mutations on the overall survival was measured by the HR and 95% CIs.
22810479	[ "##", "RESULTS" ]	[ 0, 0 ]	## RESULTS
22810479	[ ":", "The", "pooled", "HR", "for", "the", "association", "between", "K-ras", "gene", "mutations", "K-ras", " ", "gene", "mutations", "and", "overall", "survival", "in", "patients", "with", "colorectal", "cancer", "was", "1.04", "(95%", "CI:", "0.99-1.10,", "p"...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	: The pooled HR for the association between K-ras gene mutations K-ras gene mutations and overall survival in patients with colorectal cancer was 1.04 (95% CI: 0.99-1.10, p = 0.11). Subgroup analysis showed significant reductions in the overall survival associated with mutations at K-ras codon 12 , the articles that ...
22810479	[ "##", "LIMITATIONS" ]	[ 0, 0 ]	## LIMITATIONS
22810479	[ ":", "The", "heterogeneity", "in", "the", "study", "populations", "is", "a", "potential", "problem,", "the", "use", "of", "different", "staging", "systems", "or", "small", "groups", "of", "different", "stages", "may", "contribute", "to", "heterogeneity,", "and",...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	: The heterogeneity in the study populations is a potential problem, the use of different staging systems or small groups of different stages may contribute to heterogeneity, and residual confounding may have influenced the results in those studies that did not completely adjust for other factors.
22810479	[ "##", "CONCLUSIONS" ]	[ 0, 0 ]	## CONCLUSIONS
22810479	[ ":", "Overall", "K-ras", "gene", "mutations", "K-ras", "K-ras", " ", "gene", "mutation", "a", "prognostic", "factor", "for", "colorectal", "cancer:", "a", "systematic", "review", "and", "meta-analysis.", "\n\n\n", "##", "BACKGROUND" ]	[ 0, 0, 0, 0, 3, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	: Overall K-ras gene mutations K-ras K-ras gene mutation a prognostic factor for colorectal cancer: a systematic review and meta-analysis. ## BACKGROUND
22810479	[ ":", "The", "K-ras", "gene", "is", "one", "of", "the", "commonly", "mutated", "oncogenes", "associated", "with", "colorectal", "cancer.", "However,", "its", "prognostic", "significance", "for", "patients", "with", "colorectal", "cancer", "remains", "inconclusive." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	: The K-ras gene is one of the commonly mutated oncogenes associated with colorectal cancer. However, its prognostic significance for patients with colorectal cancer remains inconclusive.
22810479	[ "##", "OBJECTIVE" ]	[ 0, 0 ]	## OBJECTIVE
22810479	[ ":", "To", "derive", "a", "more", "precise", "estimation", "of", "the", "prognostic", "significance", "of", "K-ras", "gene", "mutations,", "a", "systematic", "review", "and", "meta-analysis", "were", "performed." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	: To derive a more precise estimation of the prognostic significance of K-ras gene mutations, a systematic review and meta-analysis were performed.
22810479	[ "##", "DATA", "SOURCES" ]	[ 0, 0, 0 ]	## DATA SOURCES
22810479	[ ":", "We", "searched", "PubMed,", "Embase,", "and", "the", "Cochrane", "databases", "from", "January", "1992", "to", "November", "2011." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	: We searched PubMed, Embase, and the Cochrane databases from January 1992 to November 2011.
22810479	[ "##", "STUDY", "SELECTION" ]	[ 0, 0, 0 ]	## STUDY SELECTION
22810479	[ ":", "The", "prognostic", "value", "of", "K-ras", "gene", "mutations", "was", "examined", "in", "patients", "with", "colorectal", "cancer", "who", "did", "not", "receive", "preoperative", "chemotherapy", "or", "radiation." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	: The prognostic value of K-ras gene mutations was examined in patients with colorectal cancer who did not receive preoperative chemotherapy or radiation.
22810479	[ "##", "MAIN", "OUTCOME", "MEASURES" ]	[ 0, 0, 0, 0 ]	## MAIN OUTCOME MEASURES
22810479	[ ":", "The", "effect", "of", "K-ras", "gene", "mutations", "on", "the", "overall", "survival", "was", "measured", "by", "the", "HR", "and", "95%", "CIs." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	: The effect of K-ras gene mutations on the overall survival was measured by the HR and 95% CIs.
22810479	[ "##", "RESULTS" ]	[ 0, 0 ]	## RESULTS
22810479	[ ":", "The", "pooled", "HR", "for", "the", "association", "between", "K-ras", "gene", "mutations", "and", "overall", "survival", "in", "patients", "with", "colorectal", "cancer", "was", "1.04", "(95%", "CI:", "0.99-1.10,", "p", "=", "0.11).", "Subgroup", "analy...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	: The pooled HR for the association between K-ras gene mutations and overall survival in patients with colorectal cancer was 1.04 (95% CI: 0.99-1.10, p = 0.11). Subgroup analysis showed significant reductions in the overall survival associated with mutations at K-ras codon 12, the articles that reported HR directly, an...
22810479	[ "##", "LIMITATIONS" ]	[ 0, 0 ]	## LIMITATIONS
22810479	[ ":", "The", "heterogeneity", "in", "the", "study", "populations", "is", "a", "potential", "problem,", "the", "use", "of", "different", "staging", "systems", "or", "small", "groups", "of", "different", "stages", "may", "contribute", "to", "heterogeneity,", "and",...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	: The heterogeneity in the study populations is a potential problem, the use of different staging systems or small groups of different stages may contribute to heterogeneity, and residual confounding may have influenced the results in those studies that did not completely adjust for other factors.
22810479	[ "##", "CONCLUSIONS" ]	[ 0, 0 ]	## CONCLUSIONS
22810479	[ ":", "Overall", "K-ras", "K-ras", "mutation", " ", "a", "prognostic", "factor", "for", "colorectal", "cancer:", "a", "systematic", "review", "and", "meta-analysis.", "\n\n\n", "##", "BACKGROUND" ]	[ 0, 0, 1, 1, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	: Overall K-ras K-ras mutation a prognostic factor for colorectal cancer: a systematic review and meta-analysis. ## BACKGROUND
22810479	[ ":", "The", "K-ras", "gene", "is", "one", "of", "the", "commonly", "mutated", " ", "oncogenes", "associated", "with", "colorectal", "cancer.", "However,", "its", "prognostic", "significance", "for", "patients", "with", "colorectal", "cancer", "remains", "inconclus...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	: The K-ras gene is one of the commonly mutated oncogenes associated with colorectal cancer. However, its prognostic significance for patients with colorectal cancer remains inconclusive.
22810479	[ "##", "OBJECTIVE" ]	[ 0, 0 ]	## OBJECTIVE
22810479	[ ":", "To", "derive", "a", "more", "precise", "estimation", "of", "the", "prognostic", "significance", "of", "K-ras", " ", "gene", "mutations", ",", "a", "systematic", "review", "and", "meta-analysis", "were", "performed." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0 ]	: To derive a more precise estimation of the prognostic significance of K-ras gene mutations , a systematic review and meta-analysis were performed.
22810479	[ "##", "DATA", "SOURCES" ]	[ 0, 0, 0 ]	## DATA SOURCES
22810479	[ ":", "We", "searched", "PubMed,", "Embase,", "and", "the", "Cochrane", "databases", "from", "January", "1992", "to", "November", "2011." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	: We searched PubMed, Embase, and the Cochrane databases from January 1992 to November 2011.
22810479	[ "##", "STUDY", "SELECTION" ]	[ 0, 0, 0 ]	## STUDY SELECTION
22810479	[ ":", "The", "prognostic", "value", "of", "K-ras", "gene", "mutations", "was", "examined", "in", "patients", "with", "colorectal", "cancer", "who", "did", "not", "receive", "preoperative", "chemotherapy", "or", "radiation." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	: The prognostic value of K-ras gene mutations was examined in patients with colorectal cancer who did not receive preoperative chemotherapy or radiation.
22810479	[ "##", "MAIN", "OUTCOME", "MEASURES" ]	[ 0, 0, 0, 0 ]	## MAIN OUTCOME MEASURES
22810479	[ ":", "The", "effect", "of", "K-ras", "gene", "mutations", "on", "the", "overall", "survival", "was", "measured", "by", "the", "HR", "and", "95%", "CIs." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	: The effect of K-ras gene mutations on the overall survival was measured by the HR and 95% CIs.
22810479	[ "##", "RESULTS" ]	[ 0, 0 ]	## RESULTS
22810479	[ ":", "The", "pooled", "HR", "for", "the", "association", "between", "K-ras", "gene", "mutations", "and", "overall", "survival", "in", "patients", "with", "colorectal", "cancer", "was", "1.04", "(95%", "CI:", "0.99-1.10,", "p", "=", "0.11).", "Subgroup", "analy...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	: The pooled HR for the association between K-ras gene mutations and overall survival in patients with colorectal cancer was 1.04 (95% CI: 0.99-1.10, p = 0.11). Subgroup analysis showed significant reductions in the overall survival associated with mutations at K-ras codon 12, the articles that reported HR directly, an...
22810479	[ "##", "LIMITATIONS" ]	[ 0, 0 ]	## LIMITATIONS
22810479	[ ":", "The", "heterogeneity", "in", "the", "study", "populations", "is", "a", "potential", "problem,", "the", "use", "of", "different", "staging", "systems", "or", "small", "groups", "of", "different", "stages", "may", "contribute", "to", "heterogeneity,", "and",...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	: The heterogeneity in the study populations is a potential problem, the use of different staging systems or small groups of different stages may contribute to heterogeneity, and residual confounding may have influenced the results in those studies that did not completely adjust for other factors.
22810479	[ "##", "CONCLUSIONS" ]	[ 0, 0 ]	## CONCLUSIONS
22810479	[ ":", "Overall", "K-ras", "gene", "mutations", "seem", "not", "to", "correlate", "with", "the", "prognosis", "of", "patients", "with", "colorectal", "cancer.", "The", "association", "remains", "to", "be", "confirmed", "with", "a", "more", "precise", "analysis", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	: Overall K-ras gene mutations seem not to correlate with the prognosis of patients with colorectal cancer. The association remains to be confirmed with a more precise analysis of a large sample.
22810479	[]	[]
10962562	[ "BRCA1", "activation", "of", "the", "GADD45", "promoter." ]	[ 0, 0, 0, 0, 0, 0 ]	BRCA1 activation of the GADD45 promoter.
10962562	[ "Breast", "cancer", "susceptibility", "gene", "BRCA1", "has", "been", "implicated", "in", "the", "control", "of", "gene", "regulation", "and", "such", "regulated", "genes", "are", "thought", "to", "mediate", "the", "biological", "role", "of", "BRCA1.", "Overexpr...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	Breast cancer susceptibility gene BRCA1 has been implicated in the control of gene regulation and such regulated genes are thought to mediate the biological role of BRCA1. Overexpression of BRCA1 induces GADD45, a p53-regulated and stress-inducible gene. However, the molecular mechanism by which BRCA1 induces the expre...
10962562	[ "Breast", "cancer", "susceptibility", "gene", "BRCA1", "has", "been", "implicated", "in", "the", "control", "of", "gene", "regulation", "and", "such", "regulated", "genes", "are", "thought", "to", "mediate", "the", "biological", "role", "of", "BRCA1.", "Overexpr...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	Breast cancer susceptibility gene BRCA1 has been implicated in the control of gene regulation and such regulated genes are thought to mediate the biological role of BRCA1. Overexpression of BRCA1 induces GADD45, a p53-regulated and stress-inducible gene. However, the molecular mechanism by which BRCA1 induces the expre...
10962562	[ "Breast", "cancer", "susceptibility", "gene", "BRCA1", "has", "been", "implicated", "in", "the", "control", "of", "gene", "regulation", "and", "such", "regulated", "genes", "are", "thought", "to", "mediate", "the", "biological", "role", "of", "BRCA1.", "Overexpr...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	Breast cancer susceptibility gene BRCA1 has been implicated in the control of gene regulation and such regulated genes are thought to mediate the biological role of BRCA1. Overexpression of BRCA1 induces GADD45, a p53-regulated and stress-inducible gene. However, the molecular mechanism by which BRCA1 induces the expre...
10962562	[ "Breast", "cancer", "susceptibility", "gene", "BRCA1", "has", "been", "implicated", "in", "the", "control", "of", "gene", "regulation", "and", "such", "regulated", "genes", "are", "thought", "to", "mediate", "the", "biological", "role", "of", "BRCA1.", "Overexpr...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	Breast cancer susceptibility gene BRCA1 has been implicated in the control of gene regulation and such regulated genes are thought to mediate the biological role of BRCA1. Overexpression of BRCA1 induces GADD45, a p53-regulated and stress-inducible gene. However, the molecular mechanism by which BRCA1 induces the expre...
10962562	[]	[]
22388025	[ "Editorial:", "sessile", "serrated", "adenomas", "and", "their", "pit", "patterns:", "we", "must", "first", "see", "the", "forest", "through", "the", "trees." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Editorial: sessile serrated adenomas and their pit patterns: we must first see the forest through the trees.
22388025	[ "Serrated", "lesions", "of", "the", "colorectum", "include", "hyperplastic", "polyps,", "which", "are", "non-neoplastic,", "and", "sessile", "serrated", "adenomas", "(SSAs,", "also", "known", "as", "sessile", "serrated", "polyps)", "and", "traditional", "serrated", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	Serrated lesions of the colorectum include hyperplastic polyps, which are non-neoplastic, and sessile serrated adenomas (SSAs, also known as sessile serrated polyps) and traditional serrated adenomas, which are premalignant. It is believed that up to 30% of colon cancers and many post-colonoscopy cancers arise from ser...
22388025	[]	[]
14645426	[ "Toward", "new", "strategies", "to", "select", "young", "endometrial", "cancer", "patients", "for", "mismatch", "repair", "gene", "mutation", "analysis.", "\n\n\n", "##", "PURPOSE" ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Toward new strategies to select young endometrial cancer patients for mismatch repair gene mutation analysis. ## PURPOSE
14645426	[ "To", "determine", "the", "frequency", "of", "mismatch", "repair", "(MMR)", "gene", "germline", "mutations", "in", "endometrial", "cancer", "patients", "who", "were", "diagnosed", "at", "less", "than", "50", "years", "of", "age;", "to", "relate", "the", "prese...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	To determine the frequency of mismatch repair (MMR) gene germline mutations in endometrial cancer patients who were diagnosed at less than 50 years of age; to relate the presence of mutations to family history, histopathologic data, presence of tumor microsatellite instability (MSI), and immunostaining; and to formulat...
14645426	[ "##", "PATIENTS", "AND", "METHODS" ]	[ 0, 0, 0, 0 ]	## PATIENTS AND METHODS
14645426	[ "Endometrial", "cancer", "patients", "(N", "=", "58),", "who", "were", "diagnosed", "at", "less", "than", "50", "years", "of", "age,", "were", "included", "and", "questioned", "about", "their", "family", "history.", "Mutation", "analysis", "of", "the", "MLH1,"...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	Endometrial cancer patients (N = 58), who were diagnosed at less than 50 years of age, were included and questioned about their family history. Mutation analysis of the MLH1, MSH2, and MSH6 genes was performed (denaturing gradient gel electrophoresis and sequence analysis to detect small mutations and multiplex ligatio...
14645426	[ "##", "RESULTS" ]	[ 0, 0 ]	## RESULTS
14645426	[ "In", "five", "of", "22", "patients", "with", "a", "positive", "first-degree", "family", "history", "for", "hereditary", "nonpolyposis", "colorectal", "cancer", "(HNPCC)-related", "cancers,", "pathogenic", "germline", "mutations", "mutation", " ", "analysis.", "\n\n\n...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 3, 0, 0, 0, 0, 0 ]	In five of 22 patients with a positive first-degree family history for hereditary nonpolyposis colorectal cancer (HNPCC)-related cancers, pathogenic germline mutations mutation analysis. ## PURPOSE
14645426	[ "To", "determine", "the", "frequency", "of", "mismatch", "repair", "(MMR)", "gene", "germline", "mutations", "in", "endometrial", "cancer", "patients", "who", "were", "diagnosed", "at", "less", "than", "50", "years", "of", "age;", "to", "relate", "the", "prese...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	To determine the frequency of mismatch repair (MMR) gene germline mutations in endometrial cancer patients who were diagnosed at less than 50 years of age; to relate the presence of mutations to family history, histopathologic data, presence of tumor microsatellite instability ( MSI ), and immunostaining; and to form...
14645426	[ "##", "PATIENTS", "AND", "METHODS" ]	[ 0, 0, 0, 0 ]	## PATIENTS AND METHODS
14645426	[ "Endometrial", "cancer", "patients", "(N", "=", "58),", "who", "were", "diagnosed", "at", "less", "than", "50", "years", "of", "age,", "were", "included", "and", "questioned", "about", "their", "family", "history.", "Mutation", "analysis", "of", "the", "MLH1",...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	Endometrial cancer patients (N = 58), who were diagnosed at less than 50 years of age, were included and questioned about their family history. Mutation analysis of the MLH1 , MSH2 , and MSH6 genes was performed (denaturing gradient gel electrophoresis and sequence analysis to detect small mutations and multiplex lig...
14645426	[ "##", "RESULTS" ]	[ 0, 0 ]	## RESULTS
14645426	[ "In", "five", "of", "22", "patients", "with", "a", "positive", "first-degree", "family", "history", "for", "hereditary", "nonpolyposis", "colorectal", "cancer", "(HNPCC)-related", "cancers,", "pathogenic", "germline", "mutations", "were", "found", "(one", "MLH1,", "...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	In five of 22 patients with a positive first-degree family history for hereditary nonpolyposis colorectal cancer (HNPCC)-related cancers, pathogenic germline mutations were found (one MLH1, three MSH2, and one MSH6). Four mutation carriers belonged to families fulfilling the revised Amsterdam criteria. No mutations wer...
14645426	[ "##", "RESULTS" ]	[ 0, 0 ]	## RESULTS
14645426	[ "In", "five", "of", "22", "patients", "with", "a", "positive", "first-degree", "family", "history", "for", "hereditary", "nonpolyposis", "colorectal", "cancer", "(HNPCC)-related", "cancers,", "pathogenic", "germline", "mutations", "were", "found", "(one", "MLH1,", "...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	In five of 22 patients with a positive first-degree family history for hereditary nonpolyposis colorectal cancer (HNPCC)-related cancers, pathogenic germline mutations were found (one MLH1, three MSH2, and one MSH6). Four mutation carriers belonged to families fulfilling the revised Amsterdam criteria. No mutations wer...
14645426	[ "##", "CONCLUSION" ]	[ 0, 0 ]	## CONCLUSION
14645426	[ "In", "23%", "of", "the", "young", "endometrial", "cancer", "patients", "with", "at", "least", "one", "first-degree", "relative", "with", "an", "HNPCC-related", "cancer,", "an", "MMR", "gene", "mutation", "MSI", " ", "was", "detected", "in", "20", "of", "57"...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	In 23% of the young endometrial cancer patients with at least one first-degree relative with an HNPCC-related cancer, an MMR gene mutation MSI was detected in 20 of 57 cancers, among which four were from mutation carriers. In 23 of 51 cancers, one or more MMR protein was absent; in all five mutation carriers, immunos...
14645426	[ "##", "CONCLUSION" ]	[ 0, 0 ]	## CONCLUSION
14645426	[ "In", "23%", "of", "the", "young", "endometrial", "cancer", "patients", "with", "at", "least", "one", "first-degree", "relative", "with", "an", "HNPCC-related", "cancer,", "an", "MMR", "gene", "mutation", "was", "detected.", "Therefore,", "presence", "of", "an",...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 3, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	In 23% of the young endometrial cancer patients with at least one first-degree relative with an HNPCC-related cancer, an MMR gene mutation was detected. Therefore, presence of an HNPCC-related cancer in a first-degree relative seems to be an important selection criterion for mutation mutation mutations in endometrial...
14645426	[ "##", "PATIENTS", "AND", "METHODS" ]	[ 0, 0, 0, 0 ]	## PATIENTS AND METHODS
14645426	[ "Endometrial", "cancer", "patients", "(N", "=", "58),", "who", "were", "diagnosed", "at", "less", "than", "50", "years", "of", "age,", "were", "included", "and", "questioned", "about", "their", "family", "history.", "Mutation", "analysis", "of", "the", "MLH1,"...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	Endometrial cancer patients (N = 58), who were diagnosed at less than 50 years of age, were included and questioned about their family history. Mutation analysis of the MLH1, MSH2, and MSH6 genes was performed (denaturing gradient gel electrophoresis and sequence analysis to detect small mutations and multiplex ligatio...
14645426	[ "##", "RESULTS" ]	[ 0, 0 ]	## RESULTS
14645426	[ "In", "five", "of", "22", "patients", "with", "a", "positive", "first-degree", "family", "history", "for", "hereditary", "nonpolyposis", "colorectal", "cancer", "(HNPCC)-related", "cancers,", "pathogenic", "germline", "mutations", "were", "found", "(one", "MLH1", ",...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	In five of 22 patients with a positive first-degree family history for hereditary nonpolyposis colorectal cancer (HNPCC)-related cancers, pathogenic germline mutations were found (one MLH1 , three MSH2 , and one MSH6 ). Four mutation carriers belonged to families fulfilling the revised Amsterdam criteria. No mutations ...
14645426	[ "##", "CONCLUSION" ]	[ 0, 0 ]	## CONCLUSION
14645426	[ "In", "23%", "of", "the", "young", "endometrial", "cancer", "patients", "with", "at", "least", "one", "first-degree", "relative", "with", "an", "HNPCC-related", "cancer,", "an", "MMR", "gene", "mutation", "was", "detected.", "Therefore,", "presence", "of", "an",...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	In 23% of the young endometrial cancer patients with at least one first-degree relative with an HNPCC-related cancer, an MMR gene mutation was detected. Therefore, presence of an HNPCC-related cancer in a first-degree relative seems to be an important selection criterion for mutation analysis. Subsequent immunostaining...
14645426	[]	[]
8261516	[ "Hypermutability", "and", "mismatch", "repair", "deficiency", "in", "RER+", "tumor", "cells." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Hypermutability and mismatch repair deficiency in RER+ tumor cells.
8261516	[ "A", "subset", "of", "sporadic", "colorectal", "tumors", "and", "most", "tumors", "developing", "in", "hereditary", "nonpolyposis", "colorectal", "cancer", "patients", "display", "frequent", "alterations", "in", "microsatellite", "sequences.", "Such", "tumors", "have"...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	A subset of sporadic colorectal tumors and most tumors developing in hereditary nonpolyposis colorectal cancer patients display frequent alterations in microsatellite sequences. Such tumors have been thought to manifest replication errors (RER+), but the basis for the alterations has remained conjectural. We demonstrat...
8261516	[ "A", "subset", "of", "sporadic", "colorectal", "tumors", "and", "most", "tumors", "developing", "in", "hereditary", "nonpolyposis", "colorectal", "cancer", "patients", "display", "frequent", "alterations", "in", "microsatellite", "sequences", ".", "Such", "tumors", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	A subset of sporadic colorectal tumors and most tumors developing in hereditary nonpolyposis colorectal cancer patients display frequent alterations in microsatellite sequences . Such tumors have been thought to manifest replication errors (RER+), but the basis for the alterations has remained conjectural. We demonstra...
8261516	[]	[]
16426918	[ "Mismatch", "repair", "genes", "in", "renal", "cortical", "neoplasms." ]	[ 0, 0, 0, 0, 0, 0, 0 ]	Mismatch repair genes in renal cortical neoplasms.
16426918	[ "Mutation", "of", "human", "mutL", "homolog", "1", "(MLH-1)", "and", "human", "mutS", "homolog", "2", "(MSH-2)", "has", "been", "linked", "with", "the", "pathogenesis", "of", "colorectal", "carcinoma", "in", "hereditary", "nonpolyposis", "colorectal", "cancer", ...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	Mutation of human mutL homolog 1 (MLH-1) and human mutS homolog 2 (MSH-2) has been linked with the pathogenesis of colorectal carcinoma in hereditary nonpolyposis colorectal cancer syndrome and other carcinomas. Mutations of these genes in renal cell carcinomas were recently described. The aim of this study was to exam...
16426918	[]	[]
23512527	[ "Psychosocial", "consequences", "of", "predictive", "genetic", "testing", "for", "Lynch", "syndrome", "and", "associations", "to", "surveillance", "behaviour", "in", "a", "7-year", "follow-up", "study." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	Psychosocial consequences of predictive genetic testing for Lynch syndrome and associations to surveillance behaviour in a 7-year follow-up study.
23512527	[ "We", "evaluated", "long-term", "psychosocial", "consequences", "of", "predictive", "genetic", "testing,", "and", "surveillance", "behaviour", "in", "Lynch", "syndrome", "(LS).", "We", "conducted", "a", "longitudinal", "study", "of", "208", "participants", "(62", "L...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...	We evaluated long-term psychosocial consequences of predictive genetic testing, and surveillance behaviour in Lynch syndrome (LS). We conducted a longitudinal study of 208 participants (62 LS mutation carriers and 146 non-carriers) who provided information on general anxiety (State-Trait Anxiety Inventory), fear of c...
23512527	[]	[]
20725929	[ "Leiden", "Open", "Variation", "Database", "of", "the", "MUTYH", "gene." ]	[ 0, 0, 0, 0, 0, 0, 0, 0 ]	Leiden Open Variation Database of the MUTYH gene.
20725929	[ "The", "MUTYH", "gene", "encodes", "a", "DNA", "glycosylase", "involved", "in", "base", "excision", "repair", "(BER).", "Biallelic", "pathogenic", "MUTYH", "variants", "have", "been", "associated", "with", "colorectal", "polyposis", "and", "cancer.", "The", "patho...	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 13, 0, 0, 0, 13, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, ...	The MUTYH gene encodes a DNA glycosylase involved in base excision repair (BER). Biallelic pathogenic MUTYH variants have been associated with colorectal polyposis and cancer. The pathogenicity of a few variants is beyond doubt, including c.536A4G/p.Tyr179Cys and c.1187G4A/p.Gly396Asp (previously c.494A4G / p.Tyr165Cys...

9609758

[]

7557155

[ "DNA", "mismatch", "repair", "and", "cancer." ]

[ 0, 0, 0, 0, 0 ]

DNA mismatch repair and cancer.

7557155

[ "The", "genetic", "basis", "of", "cancer", "involves", "certain", "classes", "of", "genes,", "particularly", "oncogenes,", "tumor-suppressor", "genes,", "and", "DNA", "mismatch", "repair", "genes.", "Originally", "identified", "in", "bacteria", "and", "yeast,", "the...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...

The genetic basis of cancer involves certain classes of genes, particularly oncogenes, tumor-suppressor genes, and DNA mismatch repair genes. Originally identified in bacteria and yeast, the human homologues of DNA mismatch repair genes have been implicated in the pathogenesis of the hereditary nonpolyposis colorectal ...

7557155

[]

18184403

[ "Expression", "of", "beclin-1,", "an", "autophagy-related", "protein,", "in", "gastric", "and", "colorectal", "cancers." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers.

18184403

[ "Autophagy", "plays", "important", "roles", "in", "both", "cell", "death", "and", "cell", "survival.", "Beclin-1,", "a", "key", "regulator", "of", "autophagy", "formation,", "has", "been", "considered", "as", "a", "haploinsufficient", "tumor", "suppressor.", "Loss...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...

Autophagy plays important roles in both cell death and cell survival. Beclin-1, a key regulator of autophagy formation, has been considered as a haploinsufficient tumor suppressor. Loss of expression or point mutation could serve as a mechanism of loss of beclin-1 tumor suppressor function in cancers. However, our rece...

18184403

[ "Autophagy", "plays", "important", "roles", "in", "both", "cell", "death", "and", "cell", "survival.", "Beclin-1,", "a", "key", "regulator", "of", "autophagy", "formation,", "has", "been", "considered", "as", "a", "haploinsufficient", "tumor", "suppressor.", "Loss...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...

Autophagy plays important roles in both cell death and cell survival. Beclin-1, a key regulator of autophagy formation, has been considered as a haploinsufficient tumor suppressor. Loss of expression or point mutation Beclin-1 , a key regulator of autophagy formation, has been considered as a haploinsufficient tumor su...

18184403

[]

22810479

[ "Is", "K-ras", "gene", "mutation", "a", "prognostic", "factor", "for", "colorectal", "cancer:", "a", "systematic", "review", "and", "meta-analysis.", "\n\n\n", "##", "BACKGROUND" ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

Is K-ras gene mutation a prognostic factor for colorectal cancer: a systematic review and meta-analysis. ## BACKGROUND

22810479

[ ":", "The", "K-ras", "gene", "is", "one", "of", "the", "commonly", "mutated", "oncogenes", "associated", "with", "colorectal", "cancer.", "However,", "its", "prognostic", "significance", "for", "patients", "with", "colorectal", "cancer", "remains", "inconclusive." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

: The K-ras gene is one of the commonly mutated oncogenes associated with colorectal cancer. However, its prognostic significance for patients with colorectal cancer remains inconclusive.

22810479

[ "##", "OBJECTIVE" ]

[ 0, 0 ]

## OBJECTIVE

22810479

[ ":", "To", "derive", "a", "more", "precise", "estimation", "of", "the", "prognostic", "significance", "of", "K-ras", "gene", "mutations,", "a", "systematic", "review", "and", "meta-analysis", "were", "performed." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

: To derive a more precise estimation of the prognostic significance of K-ras gene mutations, a systematic review and meta-analysis were performed.

22810479

[ "##", "DATA", "SOURCES" ]

[ 0, 0, 0 ]

## DATA SOURCES

22810479

[ ":", "We", "searched", "PubMed,", "Embase,", "and", "the", "Cochrane", "databases", "from", "January", "1992", "to", "November", "2011." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

: We searched PubMed, Embase, and the Cochrane databases from January 1992 to November 2011.

22810479

[ "##", "STUDY", "SELECTION" ]

[ 0, 0, 0 ]

## STUDY SELECTION

22810479

[ ":", "The", "prognostic", "value", "of", "K-ras", " ", "gene", "mutations", " ", "was", "examined", "in", "patients", "with", "colorectal", "cancer", "who", "did", "not", "receive", "preoperative", "chemotherapy", "or", "radiation." ]

[ 0, 0, 0, 0, 0, 1, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

: The prognostic value of K-ras gene mutations was examined in patients with colorectal cancer who did not receive preoperative chemotherapy or radiation.

22810479

[ "##", "MAIN", "OUTCOME", "MEASURES" ]

[ 0, 0, 0, 0 ]

## MAIN OUTCOME MEASURES

22810479

[ ":", "The", "effect", "of", "K-ras", " ", "gene", "mutations", " ", "on", "the", "overall", "survival", "was", "measured", "by", "the", "HR", "and", "95%", "CIs." ]

[ 0, 0, 0, 0, 1, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

: The effect of K-ras gene mutations on the overall survival was measured by the HR and 95% CIs.

22810479

[ "##", "RESULTS" ]

[ 0, 0 ]

## RESULTS

22810479

[ ":", "The", "pooled", "HR", "for", "the", "association", "between", "K-ras", "gene", "mutations", "K-ras", " ", "gene", "mutations", "and", "overall", "survival", "in", "patients", "with", "colorectal", "cancer", "was", "1.04", "(95%", "CI:", "0.99-1.10,", "p"...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...

: The pooled HR for the association between K-ras gene mutations K-ras gene mutations and overall survival in patients with colorectal cancer was 1.04 (95% CI: 0.99-1.10, p = 0.11). Subgroup analysis showed significant reductions in the overall survival associated with mutations at K-ras codon 12 , the articles that ...

22810479

[ "##", "LIMITATIONS" ]

[ 0, 0 ]

## LIMITATIONS

22810479

[ ":", "The", "heterogeneity", "in", "the", "study", "populations", "is", "a", "potential", "problem,", "the", "use", "of", "different", "staging", "systems", "or", "small", "groups", "of", "different", "stages", "may", "contribute", "to", "heterogeneity,", "and",...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

: The heterogeneity in the study populations is a potential problem, the use of different staging systems or small groups of different stages may contribute to heterogeneity, and residual confounding may have influenced the results in those studies that did not completely adjust for other factors.

22810479

[ "##", "CONCLUSIONS" ]

[ 0, 0 ]

## CONCLUSIONS

22810479

[ ":", "Overall", "K-ras", "gene", "mutations", "K-ras", "K-ras", " ", "gene", "mutation", "a", "prognostic", "factor", "for", "colorectal", "cancer:", "a", "systematic", "review", "and", "meta-analysis.", "\n\n\n", "##", "BACKGROUND" ]

[ 0, 0, 0, 0, 3, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

: Overall K-ras gene mutations K-ras K-ras gene mutation a prognostic factor for colorectal cancer: a systematic review and meta-analysis. ## BACKGROUND

22810479

[ ":", "The", "K-ras", "gene", "is", "one", "of", "the", "commonly", "mutated", "oncogenes", "associated", "with", "colorectal", "cancer.", "However,", "its", "prognostic", "significance", "for", "patients", "with", "colorectal", "cancer", "remains", "inconclusive." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

: The K-ras gene is one of the commonly mutated oncogenes associated with colorectal cancer. However, its prognostic significance for patients with colorectal cancer remains inconclusive.

22810479

[ "##", "OBJECTIVE" ]

[ 0, 0 ]

## OBJECTIVE

22810479

[ ":", "To", "derive", "a", "more", "precise", "estimation", "of", "the", "prognostic", "significance", "of", "K-ras", "gene", "mutations,", "a", "systematic", "review", "and", "meta-analysis", "were", "performed." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

: To derive a more precise estimation of the prognostic significance of K-ras gene mutations, a systematic review and meta-analysis were performed.

22810479

[ "##", "DATA", "SOURCES" ]

[ 0, 0, 0 ]

## DATA SOURCES

22810479

[ ":", "We", "searched", "PubMed,", "Embase,", "and", "the", "Cochrane", "databases", "from", "January", "1992", "to", "November", "2011." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

: We searched PubMed, Embase, and the Cochrane databases from January 1992 to November 2011.

22810479

[ "##", "STUDY", "SELECTION" ]

[ 0, 0, 0 ]

## STUDY SELECTION

22810479

[ ":", "The", "prognostic", "value", "of", "K-ras", "gene", "mutations", "was", "examined", "in", "patients", "with", "colorectal", "cancer", "who", "did", "not", "receive", "preoperative", "chemotherapy", "or", "radiation." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

: The prognostic value of K-ras gene mutations was examined in patients with colorectal cancer who did not receive preoperative chemotherapy or radiation.

22810479

[ "##", "MAIN", "OUTCOME", "MEASURES" ]

[ 0, 0, 0, 0 ]

## MAIN OUTCOME MEASURES

22810479

[ ":", "The", "effect", "of", "K-ras", "gene", "mutations", "on", "the", "overall", "survival", "was", "measured", "by", "the", "HR", "and", "95%", "CIs." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

: The effect of K-ras gene mutations on the overall survival was measured by the HR and 95% CIs.

22810479

[ "##", "RESULTS" ]

[ 0, 0 ]

## RESULTS

22810479

[ ":", "The", "pooled", "HR", "for", "the", "association", "between", "K-ras", "gene", "mutations", "and", "overall", "survival", "in", "patients", "with", "colorectal", "cancer", "was", "1.04", "(95%", "CI:", "0.99-1.10,", "p", "=", "0.11).", "Subgroup", "analy...

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: The pooled HR for the association between K-ras gene mutations and overall survival in patients with colorectal cancer was 1.04 (95% CI: 0.99-1.10, p = 0.11). Subgroup analysis showed significant reductions in the overall survival associated with mutations at K-ras codon 12, the articles that reported HR directly, an...

22810479

[ "##", "LIMITATIONS" ]

[ 0, 0 ]

## LIMITATIONS

22810479

[ ":", "The", "heterogeneity", "in", "the", "study", "populations", "is", "a", "potential", "problem,", "the", "use", "of", "different", "staging", "systems", "or", "small", "groups", "of", "different", "stages", "may", "contribute", "to", "heterogeneity,", "and",...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

: The heterogeneity in the study populations is a potential problem, the use of different staging systems or small groups of different stages may contribute to heterogeneity, and residual confounding may have influenced the results in those studies that did not completely adjust for other factors.

22810479

[ "##", "CONCLUSIONS" ]

[ 0, 0 ]

## CONCLUSIONS

22810479

[ ":", "Overall", "K-ras", "K-ras", "mutation", " ", "a", "prognostic", "factor", "for", "colorectal", "cancer:", "a", "systematic", "review", "and", "meta-analysis.", "\n\n\n", "##", "BACKGROUND" ]

[ 0, 0, 1, 1, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

: Overall K-ras K-ras mutation a prognostic factor for colorectal cancer: a systematic review and meta-analysis. ## BACKGROUND

22810479

[ ":", "The", "K-ras", "gene", "is", "one", "of", "the", "commonly", "mutated", " ", "oncogenes", "associated", "with", "colorectal", "cancer.", "However,", "its", "prognostic", "significance", "for", "patients", "with", "colorectal", "cancer", "remains", "inconclus...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

: The K-ras gene is one of the commonly mutated oncogenes associated with colorectal cancer. However, its prognostic significance for patients with colorectal cancer remains inconclusive.

22810479

[ "##", "OBJECTIVE" ]

[ 0, 0 ]

## OBJECTIVE

22810479

[ ":", "To", "derive", "a", "more", "precise", "estimation", "of", "the", "prognostic", "significance", "of", "K-ras", " ", "gene", "mutations", ",", "a", "systematic", "review", "and", "meta-analysis", "were", "performed." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0 ]

: To derive a more precise estimation of the prognostic significance of K-ras gene mutations , a systematic review and meta-analysis were performed.

22810479

[ "##", "DATA", "SOURCES" ]

[ 0, 0, 0 ]

## DATA SOURCES

22810479

[ ":", "We", "searched", "PubMed,", "Embase,", "and", "the", "Cochrane", "databases", "from", "January", "1992", "to", "November", "2011." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

: We searched PubMed, Embase, and the Cochrane databases from January 1992 to November 2011.

22810479

[ "##", "STUDY", "SELECTION" ]

[ 0, 0, 0 ]

## STUDY SELECTION

22810479

[ ":", "The", "prognostic", "value", "of", "K-ras", "gene", "mutations", "was", "examined", "in", "patients", "with", "colorectal", "cancer", "who", "did", "not", "receive", "preoperative", "chemotherapy", "or", "radiation." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

: The prognostic value of K-ras gene mutations was examined in patients with colorectal cancer who did not receive preoperative chemotherapy or radiation.

22810479

[ "##", "MAIN", "OUTCOME", "MEASURES" ]

[ 0, 0, 0, 0 ]

## MAIN OUTCOME MEASURES

22810479

[ ":", "The", "effect", "of", "K-ras", "gene", "mutations", "on", "the", "overall", "survival", "was", "measured", "by", "the", "HR", "and", "95%", "CIs." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

: The effect of K-ras gene mutations on the overall survival was measured by the HR and 95% CIs.

22810479

[ "##", "RESULTS" ]

[ 0, 0 ]

## RESULTS

22810479

[ ":", "The", "pooled", "HR", "for", "the", "association", "between", "K-ras", "gene", "mutations", "and", "overall", "survival", "in", "patients", "with", "colorectal", "cancer", "was", "1.04", "(95%", "CI:", "0.99-1.10,", "p", "=", "0.11).", "Subgroup", "analy...

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: The pooled HR for the association between K-ras gene mutations and overall survival in patients with colorectal cancer was 1.04 (95% CI: 0.99-1.10, p = 0.11). Subgroup analysis showed significant reductions in the overall survival associated with mutations at K-ras codon 12, the articles that reported HR directly, an...

22810479

[ "##", "LIMITATIONS" ]

[ 0, 0 ]

## LIMITATIONS

22810479

[ ":", "The", "heterogeneity", "in", "the", "study", "populations", "is", "a", "potential", "problem,", "the", "use", "of", "different", "staging", "systems", "or", "small", "groups", "of", "different", "stages", "may", "contribute", "to", "heterogeneity,", "and",...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

: The heterogeneity in the study populations is a potential problem, the use of different staging systems or small groups of different stages may contribute to heterogeneity, and residual confounding may have influenced the results in those studies that did not completely adjust for other factors.

22810479

[ "##", "CONCLUSIONS" ]

[ 0, 0 ]

## CONCLUSIONS

22810479

[ ":", "Overall", "K-ras", "gene", "mutations", "seem", "not", "to", "correlate", "with", "the", "prognosis", "of", "patients", "with", "colorectal", "cancer.", "The", "association", "remains", "to", "be", "confirmed", "with", "a", "more", "precise", "analysis", ...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

: Overall K-ras gene mutations seem not to correlate with the prognosis of patients with colorectal cancer. The association remains to be confirmed with a more precise analysis of a large sample.

22810479

[]

10962562

[ "BRCA1", "activation", "of", "the", "GADD45", "promoter." ]

[ 0, 0, 0, 0, 0, 0 ]

BRCA1 activation of the GADD45 promoter.

10962562

[ "Breast", "cancer", "susceptibility", "gene", "BRCA1", "has", "been", "implicated", "in", "the", "control", "of", "gene", "regulation", "and", "such", "regulated", "genes", "are", "thought", "to", "mediate", "the", "biological", "role", "of", "BRCA1.", "Overexpr...

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Breast cancer susceptibility gene BRCA1 has been implicated in the control of gene regulation and such regulated genes are thought to mediate the biological role of BRCA1. Overexpression of BRCA1 induces GADD45, a p53-regulated and stress-inducible gene. However, the molecular mechanism by which BRCA1 induces the expre...

10962562

[ "Breast", "cancer", "susceptibility", "gene", "BRCA1", "has", "been", "implicated", "in", "the", "control", "of", "gene", "regulation", "and", "such", "regulated", "genes", "are", "thought", "to", "mediate", "the", "biological", "role", "of", "BRCA1.", "Overexpr...

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Breast cancer susceptibility gene BRCA1 has been implicated in the control of gene regulation and such regulated genes are thought to mediate the biological role of BRCA1. Overexpression of BRCA1 induces GADD45, a p53-regulated and stress-inducible gene. However, the molecular mechanism by which BRCA1 induces the expre...

10962562

[ "Breast", "cancer", "susceptibility", "gene", "BRCA1", "has", "been", "implicated", "in", "the", "control", "of", "gene", "regulation", "and", "such", "regulated", "genes", "are", "thought", "to", "mediate", "the", "biological", "role", "of", "BRCA1.", "Overexpr...

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Breast cancer susceptibility gene BRCA1 has been implicated in the control of gene regulation and such regulated genes are thought to mediate the biological role of BRCA1. Overexpression of BRCA1 induces GADD45, a p53-regulated and stress-inducible gene. However, the molecular mechanism by which BRCA1 induces the expre...

10962562

[ "Breast", "cancer", "susceptibility", "gene", "BRCA1", "has", "been", "implicated", "in", "the", "control", "of", "gene", "regulation", "and", "such", "regulated", "genes", "are", "thought", "to", "mediate", "the", "biological", "role", "of", "BRCA1.", "Overexpr...

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Breast cancer susceptibility gene BRCA1 has been implicated in the control of gene regulation and such regulated genes are thought to mediate the biological role of BRCA1. Overexpression of BRCA1 induces GADD45, a p53-regulated and stress-inducible gene. However, the molecular mechanism by which BRCA1 induces the expre...

10962562

[]

22388025

[ "Editorial:", "sessile", "serrated", "adenomas", "and", "their", "pit", "patterns:", "we", "must", "first", "see", "the", "forest", "through", "the", "trees." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

Editorial: sessile serrated adenomas and their pit patterns: we must first see the forest through the trees.

22388025

[ "Serrated", "lesions", "of", "the", "colorectum", "include", "hyperplastic", "polyps,", "which", "are", "non-neoplastic,", "and", "sessile", "serrated", "adenomas", "(SSAs,", "also", "known", "as", "sessile", "serrated", "polyps)", "and", "traditional", "serrated", ...

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Serrated lesions of the colorectum include hyperplastic polyps, which are non-neoplastic, and sessile serrated adenomas (SSAs, also known as sessile serrated polyps) and traditional serrated adenomas, which are premalignant. It is believed that up to 30% of colon cancers and many post-colonoscopy cancers arise from ser...

22388025

[]

14645426

[ "Toward", "new", "strategies", "to", "select", "young", "endometrial", "cancer", "patients", "for", "mismatch", "repair", "gene", "mutation", "analysis.", "\n\n\n", "##", "PURPOSE" ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

Toward new strategies to select young endometrial cancer patients for mismatch repair gene mutation analysis. ## PURPOSE

14645426

[ "To", "determine", "the", "frequency", "of", "mismatch", "repair", "(MMR)", "gene", "germline", "mutations", "in", "endometrial", "cancer", "patients", "who", "were", "diagnosed", "at", "less", "than", "50", "years", "of", "age;", "to", "relate", "the", "prese...

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To determine the frequency of mismatch repair (MMR) gene germline mutations in endometrial cancer patients who were diagnosed at less than 50 years of age; to relate the presence of mutations to family history, histopathologic data, presence of tumor microsatellite instability (MSI), and immunostaining; and to formulat...

14645426

[ "##", "PATIENTS", "AND", "METHODS" ]

[ 0, 0, 0, 0 ]

## PATIENTS AND METHODS

14645426

[ "Endometrial", "cancer", "patients", "(N", "=", "58),", "who", "were", "diagnosed", "at", "less", "than", "50", "years", "of", "age,", "were", "included", "and", "questioned", "about", "their", "family", "history.", "Mutation", "analysis", "of", "the", "MLH1,"...

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Endometrial cancer patients (N = 58), who were diagnosed at less than 50 years of age, were included and questioned about their family history. Mutation analysis of the MLH1, MSH2, and MSH6 genes was performed (denaturing gradient gel electrophoresis and sequence analysis to detect small mutations and multiplex ligatio...

14645426

[ "##", "RESULTS" ]

[ 0, 0 ]

## RESULTS

14645426

[ "In", "five", "of", "22", "patients", "with", "a", "positive", "first-degree", "family", "history", "for", "hereditary", "nonpolyposis", "colorectal", "cancer", "(HNPCC)-related", "cancers,", "pathogenic", "germline", "mutations", "mutation", " ", "analysis.", "\n\n\n...

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 3, 0, 0, 0, 0, 0 ]

In five of 22 patients with a positive first-degree family history for hereditary nonpolyposis colorectal cancer (HNPCC)-related cancers, pathogenic germline mutations mutation analysis. ## PURPOSE

14645426

[ "To", "determine", "the", "frequency", "of", "mismatch", "repair", "(MMR)", "gene", "germline", "mutations", "in", "endometrial", "cancer", "patients", "who", "were", "diagnosed", "at", "less", "than", "50", "years", "of", "age;", "to", "relate", "the", "prese...

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To determine the frequency of mismatch repair (MMR) gene germline mutations in endometrial cancer patients who were diagnosed at less than 50 years of age; to relate the presence of mutations to family history, histopathologic data, presence of tumor microsatellite instability ( MSI ), and immunostaining; and to form...

14645426

[ "##", "PATIENTS", "AND", "METHODS" ]

[ 0, 0, 0, 0 ]

## PATIENTS AND METHODS

14645426

[ "Endometrial", "cancer", "patients", "(N", "=", "58),", "who", "were", "diagnosed", "at", "less", "than", "50", "years", "of", "age,", "were", "included", "and", "questioned", "about", "their", "family", "history.", "Mutation", "analysis", "of", "the", "MLH1",...

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Endometrial cancer patients (N = 58), who were diagnosed at less than 50 years of age, were included and questioned about their family history. Mutation analysis of the MLH1 , MSH2 , and MSH6 genes was performed (denaturing gradient gel electrophoresis and sequence analysis to detect small mutations and multiplex lig...

14645426

[ "##", "RESULTS" ]

[ 0, 0 ]

## RESULTS

14645426

[ "In", "five", "of", "22", "patients", "with", "a", "positive", "first-degree", "family", "history", "for", "hereditary", "nonpolyposis", "colorectal", "cancer", "(HNPCC)-related", "cancers,", "pathogenic", "germline", "mutations", "were", "found", "(one", "MLH1,", "...

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In five of 22 patients with a positive first-degree family history for hereditary nonpolyposis colorectal cancer (HNPCC)-related cancers, pathogenic germline mutations were found (one MLH1, three MSH2, and one MSH6). Four mutation carriers belonged to families fulfilling the revised Amsterdam criteria. No mutations wer...

14645426

[ "##", "RESULTS" ]

[ 0, 0 ]

## RESULTS

14645426

[ "In", "five", "of", "22", "patients", "with", "a", "positive", "first-degree", "family", "history", "for", "hereditary", "nonpolyposis", "colorectal", "cancer", "(HNPCC)-related", "cancers,", "pathogenic", "germline", "mutations", "were", "found", "(one", "MLH1,", "...

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In five of 22 patients with a positive first-degree family history for hereditary nonpolyposis colorectal cancer (HNPCC)-related cancers, pathogenic germline mutations were found (one MLH1, three MSH2, and one MSH6). Four mutation carriers belonged to families fulfilling the revised Amsterdam criteria. No mutations wer...

14645426

[ "##", "CONCLUSION" ]

[ 0, 0 ]

## CONCLUSION

14645426

[ "In", "23%", "of", "the", "young", "endometrial", "cancer", "patients", "with", "at", "least", "one", "first-degree", "relative", "with", "an", "HNPCC-related", "cancer,", "an", "MMR", "gene", "mutation", "MSI", " ", "was", "detected", "in", "20", "of", "57"...

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In 23% of the young endometrial cancer patients with at least one first-degree relative with an HNPCC-related cancer, an MMR gene mutation MSI was detected in 20 of 57 cancers, among which four were from mutation carriers. In 23 of 51 cancers, one or more MMR protein was absent; in all five mutation carriers, immunos...

14645426

[ "##", "CONCLUSION" ]

[ 0, 0 ]

## CONCLUSION

14645426

[ "In", "23%", "of", "the", "young", "endometrial", "cancer", "patients", "with", "at", "least", "one", "first-degree", "relative", "with", "an", "HNPCC-related", "cancer,", "an", "MMR", "gene", "mutation", "was", "detected.", "Therefore,", "presence", "of", "an",...

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In 23% of the young endometrial cancer patients with at least one first-degree relative with an HNPCC-related cancer, an MMR gene mutation was detected. Therefore, presence of an HNPCC-related cancer in a first-degree relative seems to be an important selection criterion for mutation mutation mutations in endometrial...

14645426

[ "##", "PATIENTS", "AND", "METHODS" ]

[ 0, 0, 0, 0 ]

## PATIENTS AND METHODS

14645426

[ "Endometrial", "cancer", "patients", "(N", "=", "58),", "who", "were", "diagnosed", "at", "less", "than", "50", "years", "of", "age,", "were", "included", "and", "questioned", "about", "their", "family", "history.", "Mutation", "analysis", "of", "the", "MLH1,"...

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Endometrial cancer patients (N = 58), who were diagnosed at less than 50 years of age, were included and questioned about their family history. Mutation analysis of the MLH1, MSH2, and MSH6 genes was performed (denaturing gradient gel electrophoresis and sequence analysis to detect small mutations and multiplex ligatio...

14645426

[ "##", "RESULTS" ]

[ 0, 0 ]

## RESULTS

14645426

[ "In", "five", "of", "22", "patients", "with", "a", "positive", "first-degree", "family", "history", "for", "hereditary", "nonpolyposis", "colorectal", "cancer", "(HNPCC)-related", "cancers,", "pathogenic", "germline", "mutations", "were", "found", "(one", "MLH1", ",...

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In five of 22 patients with a positive first-degree family history for hereditary nonpolyposis colorectal cancer (HNPCC)-related cancers, pathogenic germline mutations were found (one MLH1 , three MSH2 , and one MSH6 ). Four mutation carriers belonged to families fulfilling the revised Amsterdam criteria. No mutations ...

14645426

[ "##", "CONCLUSION" ]

[ 0, 0 ]

## CONCLUSION

14645426

[ "In", "23%", "of", "the", "young", "endometrial", "cancer", "patients", "with", "at", "least", "one", "first-degree", "relative", "with", "an", "HNPCC-related", "cancer,", "an", "MMR", "gene", "mutation", "was", "detected.", "Therefore,", "presence", "of", "an",...

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In 23% of the young endometrial cancer patients with at least one first-degree relative with an HNPCC-related cancer, an MMR gene mutation was detected. Therefore, presence of an HNPCC-related cancer in a first-degree relative seems to be an important selection criterion for mutation analysis. Subsequent immunostaining...

14645426

[]

8261516

[ "Hypermutability", "and", "mismatch", "repair", "deficiency", "in", "RER+", "tumor", "cells." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

Hypermutability and mismatch repair deficiency in RER+ tumor cells.

8261516

[ "A", "subset", "of", "sporadic", "colorectal", "tumors", "and", "most", "tumors", "developing", "in", "hereditary", "nonpolyposis", "colorectal", "cancer", "patients", "display", "frequent", "alterations", "in", "microsatellite", "sequences.", "Such", "tumors", "have"...

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A subset of sporadic colorectal tumors and most tumors developing in hereditary nonpolyposis colorectal cancer patients display frequent alterations in microsatellite sequences. Such tumors have been thought to manifest replication errors (RER+), but the basis for the alterations has remained conjectural. We demonstrat...

8261516

[ "A", "subset", "of", "sporadic", "colorectal", "tumors", "and", "most", "tumors", "developing", "in", "hereditary", "nonpolyposis", "colorectal", "cancer", "patients", "display", "frequent", "alterations", "in", "microsatellite", "sequences", ".", "Such", "tumors", ...

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A subset of sporadic colorectal tumors and most tumors developing in hereditary nonpolyposis colorectal cancer patients display frequent alterations in microsatellite sequences . Such tumors have been thought to manifest replication errors (RER+), but the basis for the alterations has remained conjectural. We demonstra...

8261516

[]

16426918

[ "Mismatch", "repair", "genes", "in", "renal", "cortical", "neoplasms." ]

[ 0, 0, 0, 0, 0, 0, 0 ]

Mismatch repair genes in renal cortical neoplasms.

16426918

[ "Mutation", "of", "human", "mutL", "homolog", "1", "(MLH-1)", "and", "human", "mutS", "homolog", "2", "(MSH-2)", "has", "been", "linked", "with", "the", "pathogenesis", "of", "colorectal", "carcinoma", "in", "hereditary", "nonpolyposis", "colorectal", "cancer", ...

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Mutation of human mutL homolog 1 (MLH-1) and human mutS homolog 2 (MSH-2) has been linked with the pathogenesis of colorectal carcinoma in hereditary nonpolyposis colorectal cancer syndrome and other carcinomas. Mutations of these genes in renal cell carcinomas were recently described. The aim of this study was to exam...

16426918

[]

23512527

[ "Psychosocial", "consequences", "of", "predictive", "genetic", "testing", "for", "Lynch", "syndrome", "and", "associations", "to", "surveillance", "behaviour", "in", "a", "7-year", "follow-up", "study." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

Psychosocial consequences of predictive genetic testing for Lynch syndrome and associations to surveillance behaviour in a 7-year follow-up study.

23512527

[ "We", "evaluated", "long-term", "psychosocial", "consequences", "of", "predictive", "genetic", "testing,", "and", "surveillance", "behaviour", "in", "Lynch", "syndrome", "(LS).", "We", "conducted", "a", "longitudinal", "study", "of", "208", "participants", "(62", "L...

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We evaluated long-term psychosocial consequences of predictive genetic testing, and surveillance behaviour in Lynch syndrome (LS). We conducted a longitudinal study of 208 participants (62 LS mutation carriers and 146 non-carriers) who provided information on general anxiety (State-Trait Anxiety Inventory), fear of c...

23512527

[]

20725929

[ "Leiden", "Open", "Variation", "Database", "of", "the", "MUTYH", "gene." ]

[ 0, 0, 0, 0, 0, 0, 0, 0 ]

Leiden Open Variation Database of the MUTYH gene.

20725929

[ "The", "MUTYH", "gene", "encodes", "a", "DNA", "glycosylase", "involved", "in", "base", "excision", "repair", "(BER).", "Biallelic", "pathogenic", "MUTYH", "variants", "have", "been", "associated", "with", "colorectal", "polyposis", "and", "cancer.", "The", "patho...

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The MUTYH gene encodes a DNA glycosylase involved in base excision repair (BER). Biallelic pathogenic MUTYH variants have been associated with colorectal polyposis and cancer. The pathogenicity of a few variants is beyond doubt, including c.536A4G/p.Tyr179Cys and c.1187G4A/p.Gly396Asp (previously c.494A4G / p.Tyr165Cys...