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amia_split_0404

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26925673
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Cellular proliferation, morphology and cell cycle analysis were carried out in addition to Western blotting for detecting total Akt and p-Akt (at Thr308 and Ser473) in the presence and absence of different concentrations of EA. Cell proliferation was also assessed in cells transfected with different concentrations of K...
26925673
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
26925673
[ "The", "results", "of", "the", "present", "study", "revealed", "that", "EA", "exerts", "anti-proliferative", "and", "dose-dependent", "pro-apoptotic", "effects.", "Cytostatic", "and", "cytotoxic", "effects", "were", "also", "observed.", "p-", "Akt", "Ser473", ")", ...
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The results of the present study revealed that EA exerts anti-proliferative and dose-dependent pro-apoptotic effects. Cytostatic and cytotoxic effects were also observed. p- Akt Ser473 ) in the presence and absence of different concentrations of EA. Cell proliferation was also assessed in cells transfected with differe...
26925673
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
26925673
[ "The", "results", "of", "the", "present", "study", "revealed", "that", "EA", "exerts", "anti-proliferative", "and", "dose-dependent", "pro-apoptotic", "effects.", "Cytostatic", "and", "cytotoxic", "effects", "were", "also", "observed.", "p-Akt", "(at", "Thr308", "an...
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The results of the present study revealed that EA exerts anti-proliferative and dose-dependent pro-apoptotic effects. Cytostatic and cytotoxic effects were also observed. p-Akt (at Thr308 and Ser473) was downregulated. Moreover, EA treatment was found to (i) reduce K-Ras protein expression; (ii) in cells transfected wi...
26925673
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
26925673
[ "Cellular", "genetic", "makeup", "(", "K-Ras", "-/p53-)", "was", "not", "likely", "to", "impose", "limitations", "on", "targeting", "EA", "in", "treatment", "of", "colon", "cancer.", "EA", "had", "a", "multi-disciplinary", "pro-apoptotic", "anti-proliferative", "a...
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Cellular genetic makeup ( K-Ras -/p53-) was not likely to impose limitations on targeting EA in treatment of colon cancer. EA had a multi-disciplinary pro-apoptotic anti-proliferative approach, having inhibited Akt p53 mutations have always been responsible for enhancing malignancy and silencing them is associated wi...
26925673
[ "##", "PURPOSE" ]
[ 0, 0 ]
## PURPOSE
26925673
[ "To", "evaluate", "the", "impact", "of", "cellular", "genetic", "make-", "up", "of", "two", "colon", "cancer", "cell", "lines", "with", "different", "genetic", "backgrounds,", "HCT-116", "(K-Ras-/p53+)", "and", "Caco-2", "(K-Ras+/", "p53-),", "on", "response", "...
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To evaluate the impact of cellular genetic make- up of two colon cancer cell lines with different genetic backgrounds, HCT-116 (K-Ras-/p53+) and Caco-2 (K-Ras+/ p53-), on response to potential anti-tumour effects of EA. In addition, the influence of K-Ras silencing in HCT- 116 cells was investigated.
26925673
[ "##", "MATERIALS", "AND", "METHODS" ]
[ 0, 0, 0, 0 ]
## MATERIALS AND METHODS
26925673
[ "Cellular", "proliferation,", "morphology", "and", "cell", "cycle", "analysis", "were", "carried", "out", "in", "addition", "to", "Western", "blotting", "for", "detecting", "total", "Akt", "Akt", " ", "signaling", "leads", "to", "reduction", "of", "apoptosis,", ...
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Cellular proliferation, morphology and cell cycle analysis were carried out in addition to Western blotting for detecting total Akt Akt signaling leads to reduction of apoptosis, stimulated cell growth and enhanced proliferation. Ellagic acid (EA), a naturally occurring antioxidant, has recently emerged as a promisin...
26925673
[ "##", "PURPOSE" ]
[ 0, 0 ]
## PURPOSE
26925673
[ "To", "evaluate", "the", "impact", "of", "cellular", "genetic", "make-", "up", "of", "two", "colon", "cancer", "cell", "lines", "with", "different", "genetic", "backgrounds,", "HCT-116", "(K-Ras-/p53+)", "and", "Caco-2", "(K-Ras+/", "p53-),", "on", "response", "...
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To evaluate the impact of cellular genetic make- up of two colon cancer cell lines with different genetic backgrounds, HCT-116 (K-Ras-/p53+) and Caco-2 (K-Ras+/ p53-), on response to potential anti-tumour effects of EA. In addition, the influence of K-Ras silencing in HCT- 116 cells was investigated.
26925673
[ "##", "MATERIALS", "AND", "METHODS" ]
[ 0, 0, 0, 0 ]
## MATERIALS AND METHODS
26925673
[ "Cellular", "proliferation,", "morphology", "and", "cell", "cycle", "analysis", "were", "carried", "out", "in", "addition", "to", "Western", "blotting", "for", "detecting", "total", "Akt", "and", "p-Akt", "(at", "Thr308", "and", "Ser473)", "in", "the", "presence...
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Cellular proliferation, morphology and cell cycle analysis were carried out in addition to Western blotting for detecting total Akt and p-Akt (at Thr308 and Ser473) in the presence and absence of different concentrations of EA. Cell proliferation was also assessed in cells transfected with different concentrations of K...
26925673
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
26925673
[ "The", "results", "of", "the", "present", "study", "revealed", "that", "EA", "exerts", "anti-proliferative", "and", "dose-dependent", "pro-apoptotic", "effects.", "Cytostatic", "and", "cytotoxic", "effects", "were", "also", "observed.", "p-Akt", "(at", "Thr308", "an...
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The results of the present study revealed that EA exerts anti-proliferative and dose-dependent pro-apoptotic effects. Cytostatic and cytotoxic effects were also observed. p-Akt (at Thr308 and Ser473) was downregulated. Moreover, EA treatment was found to (i) reduce K-Ras K-Ras -/p53+) and Caco-2 (K-Ras+/ p53-), on resp...
26925673
[ "##", "MATERIALS", "AND", "METHODS" ]
[ 0, 0, 0, 0 ]
## MATERIALS AND METHODS
26925673
[ "Cellular", "proliferation,", "morphology", "and", "cell", "cycle", "analysis", "were", "carried", "out", "in", "addition", "to", "Western", "blotting", "for", "detecting", "total", "Akt", "and", "p-Akt", "(at", "Thr308", "and", "Ser473)", "in", "the", "presence...
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Cellular proliferation, morphology and cell cycle analysis were carried out in addition to Western blotting for detecting total Akt and p-Akt (at Thr308 and Ser473) in the presence and absence of different concentrations of EA. Cell proliferation was also assessed in cells transfected with different concentrations of K...
26925673
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
26925673
[ "The", "results", "of", "the", "present", "study", "revealed", "that", "EA", "exerts", "anti-proliferative", "and", "dose-dependent", "pro-apoptotic", "effects.", "Cytostatic", "and", "cytotoxic", "effects", "were", "also", "observed.", "p-Akt", "(at", "Thr308", "an...
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The results of the present study revealed that EA exerts anti-proliferative and dose-dependent pro-apoptotic effects. Cytostatic and cytotoxic effects were also observed. p-Akt (at Thr308 and Ser473) was downregulated. Moreover, EA treatment was found to (i) reduce K-Ras protein expression; (ii) in cells transfected wi...
26925673
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
26925673
[ "Cellular", "genetic", "makeup", "(K-Ras-/p53-)", "was", "not", "likely", "to", "impose", "limitations", "on", "targeting", "EA", "in", "treatment", "of", "colon", "cancer.", "EA", "had", "a", "multi-disciplinary", "pro-apoptotic", "anti-proliferative", "approach,", ...
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Cellular genetic makeup (K-Ras-/p53-) was not likely to impose limitations on targeting EA in treatment of colon cancer. EA had a multi-disciplinary pro-apoptotic anti-proliferative approach, having inhibited Akt phosphorylation, induced cell cycle arrest and showed an anti-proliferative potential in HCT-116 cells (exp...
26925673
[ "##", "MATERIALS", "AND", "METHODS" ]
[ 0, 0, 0, 0 ]
## MATERIALS AND METHODS
26925673
[ "Cellular", "proliferation,", "morphology", "and", "cell", "cycle", "analysis", "were", "carried", "out", "in", "addition", "to", "Western", "blotting", "for", "detecting", "total", "Akt", "and", "p-Akt", "(at", "Thr308", "and", "Ser473)", "in", "the", "presence...
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Cellular proliferation, morphology and cell cycle analysis were carried out in addition to Western blotting for detecting total Akt and p-Akt (at Thr308 and Ser473) in the presence and absence of different concentrations of EA. Cell proliferation was also assessed in cells transfected with different concentrations of K...
26925673
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
26925673
[ "The", "results", "of", "the", "present", "study", "revealed", "that", "EA", "exerts", "anti-proliferative", "and", "dose-dependent", "pro-apoptotic", "effects.", "Cytostatic", "and", "cytotoxic", "effects", "were", "also", "observed.", "p-Akt", "(at", "Thr308", "an...
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The results of the present study revealed that EA exerts anti-proliferative and dose-dependent pro-apoptotic effects. Cytostatic and cytotoxic effects were also observed. p-Akt (at Thr308 and Ser473) was downregulated. Moreover, EA treatment was found to (i) reduce K-Ras protein expression; (ii) in cells transfected wi...
26925673
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
26925673
[ "Cellular", "genetic", "makeup", "(K-Ras-/p53-)", "was", "not", "likely", "to", "impose", "limitations", "on", "targeting", "EA", "in", "treatment", "of", "colon", "cancer.", "EA", "had", "a", "multi-disciplinary", "pro-apoptotic", "anti-proliferative", "approach,", ...
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Cellular genetic makeup (K-Ras-/p53-) was not likely to impose limitations on targeting EA in treatment of colon cancer. EA had a multi-disciplinary pro-apoptotic anti-proliferative approach, having inhibited Akt phosphorylation, induced cell cycle arrest and showed an anti-proliferative potential in HCT-116 cells (exp...
26925673
[ "##", "PURPOSE" ]
[ 0, 0 ]
## PURPOSE
26925673
[ "To", "evaluate", "the", "impact", "of", "cellular", "genetic", "make-", "up", "of", "two", "colon", "cancer", "cell", "lines", "with", "different", "genetic", "backgrounds,", "HCT-116", "(K-Ras-/p53+)", "and", "Caco-2", "(K-Ras+/", "p53", "K-Ras", " ", "activat...
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To evaluate the impact of cellular genetic make- up of two colon cancer cell lines with different genetic backgrounds, HCT-116 (K-Ras-/p53+) and Caco-2 (K-Ras+/ p53 K-Ras activation is an early event in colorectal carcinogenesis and associated mutations have been reported in about 40% of colorectal cancer patients. T...
26925673
[ "##", "PURPOSE" ]
[ 0, 0 ]
## PURPOSE
26925673
[ "To", "evaluate", "the", "impact", "of", "cellular", "genetic", "make-", "up", "of", "two", "colon", "cancer", "cell", "lines", "with", "different", "genetic", "backgrounds,", "HCT-116", "(K-Ras-/p53+)", "and", "Caco-2", "(K-Ras+/", "p53-),", "on", "response", "...
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To evaluate the impact of cellular genetic make- up of two colon cancer cell lines with different genetic backgrounds, HCT-116 (K-Ras-/p53+) and Caco-2 (K-Ras+/ p53-), on response to potential anti-tumour effects of EA. In addition, the influence of K-Ras silencing in HCT- 116 cells was investigated.
26925673
[ "##", "MATERIALS", "AND", "METHODS" ]
[ 0, 0, 0, 0 ]
## MATERIALS AND METHODS
26925673
[ "Cellular", "proliferation,", "morphology", "and", "cell", "cycle", "analysis", "were", "carried", "out", "in", "addition", "to", "Western", "blotting", "for", "detecting", "total", "Akt", "and", "p-Akt", "(at", "Thr308", "Ak", "t", "(at", "Thr308", "and", "Se...
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Cellular proliferation, morphology and cell cycle analysis were carried out in addition to Western blotting for detecting total Akt and p-Akt (at Thr308 Ak t (at Thr308 and Ser473) in the presence and absence of different concentrations of EA. Cell proliferation was also assessed in cells transfected with different con...
26925673
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
26925673
[ "The", "results", "of", "the", "present", "study", "revealed", "that", "EA", "exerts", "anti-proliferative", "and", "dose-dependent", "pro-apoptotic", "effects.", "Cytostatic", "and", "cytotoxic", "effects", "were", "also", "observed.", "p-Akt", "(at", "Thr308", " "...
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The results of the present study revealed that EA exerts anti-proliferative and dose-dependent pro-apoptotic effects. Cytostatic and cytotoxic effects were also observed. p-Akt (at Thr308 and Ser473 ) was downregulated. Moreover, EA treatment was found to (i) reduce K-Ras protein expression; (ii) in cells transfected...
26925673
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
26925673
[ "Cellular", "genetic", "makeup", "(K-Ras-/p53-)", "was", "not", "likely", "to", "impose", "limitations", "on", "targeting", "EA", "in", "treatment", "of", "colon", "cancer.", "EA", "had", "a", "multi-disciplinary", "pro-apoptotic", "anti-proliferative", "approach,", ...
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Cellular genetic makeup (K-Ras-/p53-) was not likely to impose limitations on targeting EA in treatment of colon cancer. EA had a multi-disciplinary pro-apoptotic anti-proliferative approach, having inhibited Akt phosphorylation, induced cell cycle arrest and showed an anti-proliferative potential in HCT-116 cells (exp...
26925673
[]
[]
9731891
[ "Microsatellite", "instability", "and", "p53", "mutations", "in", "sporadic", "right", "and", "left", "colon", "carcinoma:", "different", "clinical", "and", "molecular", "implications.", "\n\n\n", "##", "BACKGROUND" ]
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Microsatellite instability and p53 mutations in sporadic right and left colon carcinoma: different clinical and molecular implications. ## BACKGROUND
9731891
[ "Left", "and", "right", "colon", "carcinomas", "can", "display", "different", "clinical,", "pathologic,", "and", "genetic", "characteristics.", "The", "purpose", "of", "this", "study", "was", "to", "characterize", "multiple", "molecular", "genetic", "alterations", "...
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Left and right colon carcinomas can display different clinical, pathologic, and genetic characteristics. The purpose of this study was to characterize multiple molecular genetic alterations in sporadic colon carcinoma and to correlate them with the location of the tumors and with lymph node metastasis.
9731891
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
9731891
[ "One", "hundred", "and", "twenty-five", "cases", "of", "sporadic", "colon", "carcinoma", "(50", "in", "the", "right", "colon", "and", "75", "in", "the", "left", "colon", "in", "patients", "with", "no", "family", "history", "of", "colon", "carcinoma)", "were"...
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One hundred and twenty-five cases of sporadic colon carcinoma (50 in the right colon and 75 in the left colon in patients with no family history of colon carcinoma) were studied. Status of the p53 gene was assessed by polymerase chain reaction (PCR), single strand conformation polymorphism, and sequencing at exons 5-8....
9731891
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
9731891
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In the 125 cases studied, there were 53 tumors with mutations of the p53 gene. p53 mutations correlated with lymph node metastases from right colon carcinoma cases (61%), and all cases with p53 mutations and microsatellite instability were AJCC/UICC Stage III (Dukes Stage C). In the right colon carcinoma cases the rate...
9731891
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
9731891
[ "Microsatellite", "instability", "is", "prone", "to", "occur", "in", "sporadic", "right", "colon", "carcinoma", "during", "tumor", "growth", "and", "is", "not", "associated", "significantly", "with", "mutations", "in", "the", "hMLH1", "and", "hMSH2", "microsatelli...
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Microsatellite instability is prone to occur in sporadic right colon carcinoma during tumor growth and is not associated significantly with mutations in the hMLH1 and hMSH2 microsatellite instability by PCR and sequencing.
9731891
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
9731891
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In the 125 cases studied, there were 53 tumors with mutations of the p53 gene. p53 mutations correlated with lymph node metastases from right colon carcinoma cases (61%), and all cases with p53 mutations and microsatellite instability were AJCC/UICC Stage III (Dukes Stage C). In the right colon carcinoma cases the ra...
9731891
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
9731891
[ "Microsatellite", "instability", "is", "prone", "to", "occur", "in", "sporadic", "right", "colon", "carcinoma", "during", "tumor", "growth", "and", "is", "not", "associated", "significantly", "with", "mutations", "in", "the", "hMLH1", " ", "and", "hMSH2", "misma...
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Microsatellite instability is prone to occur in sporadic right colon carcinoma during tumor growth and is not associated significantly with mutations in the hMLH1 and hMSH2 mismatch repair genes or in the p53 p53 gene. p53 mutations correlated with lymph node metastases from right colon carcinoma cases (61%), and a...
9731891
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
9731891
[ "Microsatellite", "instability", "is", "prone", "to", "occur", "in", "sporadic", "right", "colon", "carcinoma", "during", "tumor", "growth", "and", "is", "not", "associated", "significantly", "with", "mutations", "in", "the", "hMLH1", "and", "hMSH2", "mismatch", ...
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Microsatellite instability is prone to occur in sporadic right colon carcinoma during tumor growth and is not associated significantly with mutations in the hMLH1 and hMSH2 mismatch repair genes or in the p53 gene. Concomitant detection of microsatellite instability and p53 mutations mutations correlated with lymph n...
9731891
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
9731891
[ "Microsatellite", "instability", "is", "prone", "to", "occur", "in", "sporadic", "right", "colon", "carcinoma", "during", "tumor", "growth", "and", "is", "not", "associated", "significantly", "with", "mutations", "in", "the", "hMLH1", "and", "hMSH2", "mismatch", ...
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Microsatellite instability is prone to occur in sporadic right colon carcinoma during tumor growth and is not associated significantly with mutations in the hMLH1 and hMSH2 mismatch repair genes or in the p53 gene. Concomitant detection of microsatellite instability and p53 p53 mutations correlated with lymph node me...
9731891
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
9731891
[ "Microsatellite", "instability", "mutations", "Microsatellite", "instability", " ", "and", "p53", "mutations", "in", "sporadic", "right", "and", "left", "colon", "carcinoma:", "different", "clinical", "and", "molecular", "implications.", "\n\n\n", "##", "BACKGROUND" ]
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Microsatellite instability mutations Microsatellite instability and p53 mutations in sporadic right and left colon carcinoma: different clinical and molecular implications. ## BACKGROUND
9731891
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Left and right colon carcinomas can display different clinical, pathologic, and genetic characteristics. The purpose of this study was to characterize multiple molecular genetic alterations in sporadic colon carcinoma and to correlate them with the location of the tumors and with lymph node metastasis.
9731891
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
9731891
[ "One", "hundred", "and", "twenty-five", "cases", "of", "sporadic", "colon", "carcinoma", "(50", "in", "the", "right", "colon", "and", "75", "in", "the", "left", "colon", "in", "patients", "with", "no", "family", "history", "of", "colon", "carcinoma)", "were"...
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One hundred and twenty-five cases of sporadic colon carcinoma (50 in the right colon and 75 in the left colon in patients with no family history of colon carcinoma) were studied. Status of the p53 gene was assessed by polymerase chain reaction (PCR), single strand conformation polymorphism, and sequencing at exons 5-8....
9731891
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
9731891
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In the 125 cases studied, there were 53 tumors with mutations of the p53 gene. p53 mutations correlated with lymph node metastases from right colon carcinoma cases (61%), and all cases with p53 mutations and microsatellite instability were AJCC/UICC Stage III (Dukes Stage C). In the right colon carcinoma cases the rate...
9731891
[ "Left", "and", "right", "colon", "carcinomas", "can", "display", "different", "clinical,", "pathologic,", "and", "genetic", "characteristics.", "The", "purpose", "of", "this", "study", "was", "to", "characterize", "multiple", "molecular", "genetic", "alterations", "...
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Left and right colon carcinomas can display different clinical, pathologic, and genetic characteristics. The purpose of this study was to characterize multiple molecular genetic alterations in sporadic colon carcinoma and to correlate them with the location of the tumors and with lymph node metastasis.
9731891
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
9731891
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One hundred and twenty-five cases of sporadic colon carcinoma (50 in the right colon and 75 in the left colon in patients with no family history of colon carcinoma) were studied. Status of the p53 gene was assessed by polymerase chain reaction (PCR), single strand conformation polymorphism, and sequencing at exons 5-8....
9731891
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
9731891
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In the 125 cases studied, there were 53 tumors with mutations of the p53 gene. p53 mutations correlated with lymph node metastases from right colon carcinoma cases (61%), and all cases with p53 mutations and microsatellite instability were AJCC/UICC Stage III (Dukes Stage C). In the right colon carcinoma cases the rate...
9731891
[ "Left", "and", "right", "colon", "carcinomas", "can", "display", "different", "clinical,", "pathologic,", "and", "genetic", "characteristics.", "The", "purpose", "of", "this", "study", "was", "to", "characterize", "multiple", "molecular", "genetic", "alterations", "...
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Left and right colon carcinomas can display different clinical, pathologic, and genetic characteristics. The purpose of this study was to characterize multiple molecular genetic alterations in sporadic colon carcinoma and to correlate them with the location of the tumors and with lymph node metastasis.
9731891
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
9731891
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One hundred and twenty-five cases of sporadic colon carcinoma (50 in the right colon and 75 in the left colon in patients with no family history of colon carcinoma) were studied. Status of the p53 gene was assessed by polymerase chain reaction (PCR), single strand conformation polymorphism, and sequencing at exons 5-8....
9731891
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
9731891
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In the 125 cases studied, there were 53 tumors with mutations of the p53 gene. p53 mutations correlated with lymph node metastases from right colon carcinoma cases (61%), and all cases with p53 mutations and microsatellite instability exons 5-8 p53 gene was assessed by polymerase chain reaction (PCR), single strand c...
9731891
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
9731891
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In the 125 cases studied, there were 53 tumors with mutations of the p53 gene. p53 mutations correlated with lymph node metastases from right colon carcinoma cases (61%), and all cases with p53 mutations and microsatellite instability were AJCC/UICC Stage III (Dukes Stage C). In the right colon carcinoma cases the rate...
9731891
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
9731891
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In the 125 cases studied, there were 53 tumors with mutations of the p53 gene. p53 mutations correlated with lymph node metastases from right colon carcinoma cases (61%), and all cases with p53 mutations and microsatellite instability were AJCC/UICC Stage III (Dukes Stage C). In the right colon carcinoma cases the rate...
9731891
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
9731891
[ "Microsatellite", "instability", "is", "prone", "to", "occur", "in", "sporadic", "right", "colon", "carcinoma", "during", "tumor", "growth", "and", "is", "not", "associated", "significantly", "with", "mutations", "in", "the", "hMLH1", "and", "hMSH2", "mismatch", ...
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Microsatellite instability is prone to occur in sporadic right colon carcinoma during tumor growth and is not associated significantly with mutations in the hMLH1 and hMSH2 mismatch repair genes or in the p53 gene. Concomitant detection of microsatellite instability Microsatellite instability was analyzed with five m...
9731891
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
9731891
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In the 125 cases studied, there were 53 tumors with mutations of the p53 gene. p53 mutations correlated with lymph node metastases from right colon carcinoma cases (61%), and all cases with p53 mutations and microsatellite instability were AJCC/UICC Stage III (Dukes Stage C). In the right colon carcinoma cases the rate...
9731891
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
9731891
[ "Microsatellite", "instability", "is", "prone", "to", "occur", "in", "sporadic", "right", "colon", "carcinoma", "during", "tumor", "growth", "and", "is", "not", "associated", "significantly", "with", "mutations", "genetic", "alterations", " ", "in", "sporadic", "c...
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Microsatellite instability is prone to occur in sporadic right colon carcinoma during tumor growth and is not associated significantly with mutations genetic alterations in sporadic colon carcinoma and to correlate them with the location of the tumors and with lymph node metastasis.
9731891
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
9731891
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One hundred and twenty-five cases of sporadic colon carcinoma (50 in the right colon and 75 in the left colon in patients with no family history of colon carcinoma) were studied. Status of the p53 gene was assessed by polymerase chain reaction (PCR), single strand conformation polymorphism, and sequencing at exons 5-8....
9731891
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
9731891
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In the 125 cases studied, there were 53 tumors with mutations of the p53 gene. p53 mutations correlated with lymph node metastases from right colon carcinoma cases (61%), and all cases with p53 mutations and microsatellite instability were AJCC/UICC Stage III (Dukes Stage C). In the right colon carcinoma cases the rate...
9731891
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
9731891
[ "Microsatellite", "instability", "is", "prone", "to", "occur", "in", "sporadic", "right", "colon", "carcinoma", "during", "tumor", "growth", "and", "is", "not", "associated", "significantly", "with", "mutations", "in", "the", "hMLH1", "and", "hMSH2", "mismatch", ...
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Microsatellite instability is prone to occur in sporadic right colon carcinoma during tumor growth and is not associated significantly with mutations in the hMLH1 and hMSH2 mismatch repair genes or in the p53 gene. Concomitant detection of microsatellite instability and p53 mutations in right colon carcinoma is associa...
9731891
[]
[]
14966376
[ "Genetic", "analysis", "of", "the", "APC", "gene", "in", "Taiwanese", "familial", "adenomatous", "polyposis." ]
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Genetic analysis of the APC gene in Taiwanese familial adenomatous polyposis.
14966376
[ "Colorectal", "cancer", "has", "become", "the", "third", "leading", "cause", "of", "death", "from", "cancer", "in", "Taiwan.", "Familial", "adenomatous", "polyposis", "(FAP)", "is", "an", "autosomal", "dominant", "inherited", "disease", "characterized", "by", "the...
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Colorectal cancer has become the third leading cause of death from cancer in Taiwan. Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease characterized by the presence of multiple adenomatous polyps in the colon and rectum. The gene responsible for FAP (APC) was cloned in 1991. Extensive anal...
14966376
[ "Colorectal", "cancer", "has", "become", "the", "third", "leading", "cause", "of", "death", "from", "cancer", "in", "Taiwan.", "Familial", "adenomatous", "polyposis", "(FAP)", "is", "an", "autosomal", "dominant", "inherited", "disease", "characterized", "by", "the...
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Colorectal cancer has become the third leading cause of death from cancer in Taiwan. Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease characterized by the presence of multiple adenomatous polyps in the colon and rectum. The gene responsible for FAP (APC) was cloned in 1991. Extensive anal...
14966376
[]
[]
16396368
[ "[Hereditary", "non", "polyposis", "colon", "cancer--basic", "principle", "and", "ethical", "considerations]." ]
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[Hereditary non polyposis colon cancer--basic principle and ethical considerations].
16396368
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HNPCC is a hereditary cancer syndrome of several organs but more particularly the colon and the uterus. It is characterized by microsatellite instability (MSI) related to mutations MSI ) related to mutations of DNA mismatch repair (MMR) genes. The role of the pathologist in the detection of colorectal cancer with MSI...
16396368
[]
[]
12534642
[ "Polymorphisms", "in", "the", "cytochrome", "P450", "CYP1A2", "gene", "(CYP1A2)", "in", "colorectal", "cancer", "patients", "and", "controls:", "allele", "frequencies,", "linkage", "disequilibrium", "and", "influence", "on", "caffeine", "metabolism.", "\n\n\n", "##", ...
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Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism. ## AIMS
12534642
[ "Several", "single", "nucleotide", "polymorphisms", "(SNPs)", "of", "the", "cytochrome", "P450", "enzyme", "1A2", "gene", "(CYP1A2)", "have", "been", "reported.", "Here,", "frequencies,", "linkage", "disequilibrium", "and", "phenotypic", "consequences", "of", "six", ...
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Several single nucleotide polymorphisms (SNPs) of the cytochrome P450 enzyme 1A2 gene (CYP1A2) have been reported. Here, frequencies, linkage disequilibrium and phenotypic consequences of six SNPs are described.
12534642
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS