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amia_split_0404

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12534642
[ "From", "genomic", "DNA,", "114", "British", "Caucasians", "(49", "colorectal", "cancer", "cases", "and", "65", "controls)", "were", "genotyped", "for", "the", "CYP1A2", "polymorphisms", "-3858G-->A", "(allele", "CYP1A2*1C),", "-2464T-->delT", "(CYP1A2*1D),", "-740T--...
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From genomic DNA, 114 British Caucasians (49 colorectal cancer cases and 65 controls) were genotyped for the CYP1A2 polymorphisms -3858G-->A (allele CYP1A2*1C), -2464T-->delT (CYP1A2*1D), -740T-->G (CYP1A2*1E and *1G), -164A-->C (CYP1A2*1F), 63C-->G (CYP1A2*2), and 1545T-->C (alleles CYP1A2*1B, *1G, *1H and *3), using ...
12534642
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
12534642
[ "In", "114", "samples,", "the", "most", "frequent", "CYP1A2", "SNPs", "were", "1545T-->C", "(38.2%", "of", "tested", "chromosomes),", "-164A-->C", "(CYP1A2*1F,", "33.3%)", "and", "-2464T-->delT", "(CYP1A2*1D,", "4.82%).", "The", "SNPs", "were", "in", "linkage", "d...
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In 114 samples, the most frequent CYP1A2 SNPs were 1545T-->C (38.2% of tested chromosomes), -164A-->C (CYP1A2*1F, 33.3%) and -2464T-->delT (CYP1A2*1D, 4.82%). The SNPs were in linkage disequilibrium: the most frequent constellations were found to be -3858G/-2464T/-740T/-164A/63C/1545T (61.8%), -3858G/-2464T/-740T/-164C...
12534642
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
12534642
[ "From", "genomic", "DNA,", "114", "British", "Caucasians", "(49", "colorectal", "cancer", "cases", "and", "65", "controls)", "were", "genotyped", "for", "the", "CYP1A2", "polymorphisms", "-3858G-->A", "(allele", "CYP1A2*1C),", "-2464T-->delT", "(CYP1A2*1D),", "-740T--...
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From genomic DNA, 114 British Caucasians (49 colorectal cancer cases and 65 controls) were genotyped for the CYP1A2 polymorphisms -3858G-->A (allele CYP1A2*1C), -2464T-->delT (CYP1A2*1D), -740T-->G (CYP1A2*1E and *1G), -164A-->C (CYP1A2*1F), 63C-->G (CYP1A2*2), and 1545T-->C (alleles CYP1A2*1B, *1G, *1H and *3), using ...
12534642
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
12534642
[ "In", "114", "samples,", "the", "most", "frequent", "CYP1A2", "SNPs", "were", "1545T-->C", "(38.2%", "of", "tested", "chromosomes),", "-164A-->C", "(CYP1A2*1F,", "33.3%)", "and", "-2464T-->delT", "(CYP1A2*1D,", "4.82%).", "The", "SNPs", "were", "in", "linkage", "d...
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In 114 samples, the most frequent CYP1A2 SNPs were 1545T-->C (38.2% of tested chromosomes), -164A-->C (CYP1A2*1F, 33.3%) and -2464T-->delT (CYP1A2*1D, 4.82%). The SNPs were in linkage disequilibrium: the most frequent constellations were found to be -3858G/-2464T/-740T/-164A/63C/1545T (61.8%), -3858G/-2464T/-740T/-164C...
12534642
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
12534642
[ "(i)", "CYP1A2", "cytochrome", "P450", "enzyme", "1A2", " ", "gene", "(CYP1A2)", "have", "been", "reported.", "Here,", "frequencies,", "linkage", "disequilibrium", "and", "phenotypic", "consequences", "of", "six", "SNPs", "are", "described." ]
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(i) CYP1A2 cytochrome P450 enzyme 1A2 gene (CYP1A2) have been reported. Here, frequencies, linkage disequilibrium and phenotypic consequences of six SNPs are described.
12534642
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
12534642
[ "From", "genomic", "DNA,", "114", "British", "Caucasians", "(49", "colorectal", "cancer", "cases", "and", "65", "controls)", "were", "genotyped", "for", "the", "CYP1A2", "polymorphisms", "-3858G-->A", "(allele", "CYP1A2*1C),", "-2464T-->delT", "(CYP1A2*1D),", "-740T--...
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From genomic DNA, 114 British Caucasians (49 colorectal cancer cases and 65 controls) were genotyped for the CYP1A2 polymorphisms -3858G-->A (allele CYP1A2*1C), -2464T-->delT (CYP1A2*1D), -740T-->G (CYP1A2*1E and *1G), -164A-->C (CYP1A2*1F), 63C-->G (CYP1A2*2), and 1545T-->C (alleles CYP1A2*1B, *1G, *1H and *3), using ...
12534642
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
12534642
[ "In", "114", "samples,", "the", "most", "frequent", "CYP1A2", "SNPs", "were", "1545T-->C", "(38.2%", "of", "tested", "chromosomes),", "-164A-->C", "(CYP1A2*1F,", "33.3%)", "and", "-2464T-->delT", "(CYP1A2*1D,", "4.82%).", "The", "SNPs", "were", "in", "linkage", "d...
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In 114 samples, the most frequent CYP1A2 SNPs were 1545T-->C (38.2% of tested chromosomes), -164A-->C (CYP1A2*1F, 33.3%) and -2464T-->delT (CYP1A2*1D, 4.82%). The SNPs were in linkage disequilibrium: the most frequent constellations were found to be -3858G/-2464T/-740T/-164A/63C/1545T (61.8%), -3858G/-2464T/-740T/-164C...
12534642
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
12534642
[ "(i)", "CYP1A2", "polymorphisms", " ", "are", "in", "linkage", "disequilibrium.", "Therefore,", "only", "-164A-->C", "(CYP1A2*1F)", "and", "-2464T-->delT", "-3858G-->A", " ", "(allele", "CYP1A2*1C),", "-2464T-->delT", " ", "(CYP1A2*1D),", "-740T-->G", "(CYP1A2*1E", "and...
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(i) CYP1A2 polymorphisms are in linkage disequilibrium. Therefore, only -164A-->C (CYP1A2*1F) and -2464T-->delT -3858G-->A (allele CYP1A2*1C), -2464T-->delT (CYP1A2*1D), -740T-->G (CYP1A2*1E and *1G), -164A-->C (CYP1A2*1F), 63C-->G (CYP1A2*2), and 1545T-->C (alleles CYP1A2*1B, *1G, *1H and *3), using polymerase c...
12534642
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
12534642
[ "In", "114", "samples,", "the", "most", "frequent", "CYP1A2", "SNPs", "were", "1545T-->C", "(38.2%", "of", "tested", "chromosomes),", "-164A-->C", "(CYP1A2*1F,", "33.3%)", "and", "-2464T-->delT", "(CYP1A2*1D,", "4.82%).", "The", "SNPs", "were", "in", "linkage", "d...
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In 114 samples, the most frequent CYP1A2 SNPs were 1545T-->C (38.2% of tested chromosomes), -164A-->C (CYP1A2*1F, 33.3%) and -2464T-->delT (CYP1A2*1D, 4.82%). The SNPs were in linkage disequilibrium: the most frequent constellations were found to be -3858G/-2464T/-740T/-164A/63C/1545T (61.8%), -3858G/-2464T/-740T/-164C...
12534642
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
12534642
[ "(i)", "CYP1A2", "polymorphisms", "are", "in", "linkage", "disequilibrium.", "Therefore,", "only", "-164A-->C", "(", "CYP1A2*1F", "CYP1A2*1C", "),", "-2464T-->delT", "(CYP1A2*1D),", "-740T-->G", "(CYP1A2*1E", "and", "*1G),", "-164A-->C", "(CYP1A2*1F),", "63C-->G", "(CYP...
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(i) CYP1A2 polymorphisms are in linkage disequilibrium. Therefore, only -164A-->C ( CYP1A2*1F CYP1A2*1C ), -2464T-->delT (CYP1A2*1D), -740T-->G (CYP1A2*1E and *1G), -164A-->C (CYP1A2*1F), 63C-->G (CYP1A2*2), and 1545T-->C (alleles CYP1A2*1B, *1G, *1H and *3), using polymerase chain reaction-restriction fragment length ...
12534642
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
12534642
[ "In", "114", "samples,", "the", "most", "frequent", "CYP1A2", "SNPs", "were", "1545T-->C", "(38.2%", "of", "tested", "chromosomes),", "-164A-->C", "(CYP1A2*1F,", "33.3%)", "and", "-2464T-->delT", "(CYP1A2*1D,", "4.82%).", "The", "SNPs", "were", "in", "linkage", "d...
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In 114 samples, the most frequent CYP1A2 SNPs were 1545T-->C (38.2% of tested chromosomes), -164A-->C (CYP1A2*1F, 33.3%) and -2464T-->delT (CYP1A2*1D, 4.82%). The SNPs were in linkage disequilibrium: the most frequent constellations were found to be -3858G/-2464T/-740T/-164A/63C/1545T (61.8%), -3858G/-2464T/-740T/-164C...
12534642
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
12534642
[ "(i)", "CYP1A2", "polymorphisms", "are", "in", "linkage", "disequilibrium.", "Therefore,", "only", "-164A-->C", "(CYP1A2*1F)", "and", "-2464T-->delT", "(CYP1A2*1D)", "need", "to", "be", "analysed", "in", "the", "routine", "assessment", "of", "CYP1A2", "CYP1A2", "sin...
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(i) CYP1A2 polymorphisms are in linkage disequilibrium. Therefore, only -164A-->C (CYP1A2*1F) and -2464T-->delT (CYP1A2*1D) need to be analysed in the routine assessment of CYP1A2 CYP1A2 single nucleotide polymorphisms (SNPs) of the cytochrome P450 enzyme 1A2 gene (CYP1A2) have been reported. Here, frequencies, linka...
12534642
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
12534642
[ "From", "genomic", "DNA,", "114", "British", "Caucasians", "(49", "colorectal", "cancer", "cases", "and", "65", "controls)", "were", "genotyped", "for", "the", "CYP1A2", " ", "polymorphisms", " ", "-3858G-->A", "(allele", "CYP1A2*1C),", "-2464T-->delT", "(CYP1A2*1D)...
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From genomic DNA, 114 British Caucasians (49 colorectal cancer cases and 65 controls) were genotyped for the CYP1A2 polymorphisms -3858G-->A (allele CYP1A2*1C), -2464T-->delT (CYP1A2*1D), -740T-->G (CYP1A2*1E and *1G), -164A-->C (CYP1A2*1F), 63C-->G (CYP1A2*2), and 1545T-->C (alleles CYP1A2*1B, *1G, *1H and *3), us...
12534642
[ "Several", "single", "nucleotide", "polymorphisms", "(SNPs)", "of", "the", "cytochrome", "P450", "enzyme", "1A2", "gene", "(CYP1A2)", "have", "been", "reported.", "Here,", "frequencies,", "linkage", "disequilibrium", "and", "phenotypic", "consequences", "of", "six", ...
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Several single nucleotide polymorphisms (SNPs) of the cytochrome P450 enzyme 1A2 gene (CYP1A2) have been reported. Here, frequencies, linkage disequilibrium and phenotypic consequences of six SNPs are described.
12534642
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
12534642
[ "From", "genomic", "DNA,", "114", "British", "Caucasians", "(49", "colorectal", "cancer", "cases", "and", "65", "controls)", "were", "genotyped", "for", "the", "CYP1A2", "polymorphisms", "-3858G-->A", "(allele", "CYP1A2*1C),", "-2464T-->delT", "(CYP1A2*1D),", "-740T--...
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From genomic DNA, 114 British Caucasians (49 colorectal cancer cases and 65 controls) were genotyped for the CYP1A2 polymorphisms -3858G-->A (allele CYP1A2*1C), -2464T-->delT (CYP1A2*1D), -740T-->G (CYP1A2*1E and *1G), -164A-->C (CYP1A2*1F), 63C-->G (CYP1A2*2), and 1545T-->C (alleles CYP1A2*1B, *1G, *1H and *3), using ...
12534642
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
12534642
[ "In", "114", "samples,", "the", "most", "frequent", "CYP1A2", "SNPs", "were", "1545T-->C", "(38.2%", "of", "tested", "chromosomes),", "-164A-->C", "(CYP1A2*1F,", "33.3%)", "and", "-2464T-->delT", "(CYP1A2*1D,", "4.82%).", "The", "SNPs", "were", "in", "linkage", "d...
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In 114 samples, the most frequent CYP1A2 SNPs were 1545T-->C (38.2% of tested chromosomes), -164A-->C (CYP1A2*1F, 33.3%) and -2464T-->delT (CYP1A2*1D, 4.82%). The SNPs were in linkage disequilibrium: the most frequent constellations were found to be -3858G/-2464T/-740T/-164A/63C/1545T (61.8%), -3858G/-2464T/-740T/-164C...
12534642
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
12534642
[ "(i)", "CYP1A2", "polymorphisms", "are", "in", "linkage", "disequilibrium.", "Therefore,", "only", "-164A-->C", "(CYP1A2*1F)", "and", "-2464T-->delT", "(", "CYP1A2*1D", ")", "need", "to", "be", "analysed", "in", "the", "routine", "assessment", "of", "CYP1A2", "gen...
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(i) CYP1A2 polymorphisms are in linkage disequilibrium. Therefore, only -164A-->C (CYP1A2*1F) and -2464T-->delT ( CYP1A2*1D ) need to be analysed in the routine assessment of CYP1A2 genotype; (ii) in vivo CYP1A2 activity is lower in colorectal cancer patients than in controls, and (iii) CYP1A2 -740T-->G (CYP1A2*1E an...
12534642
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
12534642
[ "In", "114", "samples,", "the", "most", "frequent", "CYP1A2", "SNPs", "were", "1545T-->C", "(38.2%", "of", "tested", "chromosomes),", "-164A-->C", "(CYP1A2*1F,", "33.3%)", "and", "-2464T-->delT", "(CYP1A2*1D,", "4.82%).", "The", "SNPs", "were", "in", "linkage", "d...
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In 114 samples, the most frequent CYP1A2 SNPs were 1545T-->C (38.2% of tested chromosomes), -164A-->C (CYP1A2*1F, 33.3%) and -2464T-->delT (CYP1A2*1D, 4.82%). The SNPs were in linkage disequilibrium: the most frequent constellations were found to be -3858G/-2464T/-740T/-164A/63C/1545T (61.8%), -3858G/-2464T/-740T/-164C...
12534642
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
12534642
[ "(i)", "CYP1A2", "polymorphisms", "are", "in", "linkage", "disequilibrium.", "Therefore,", "only", "-164A-->C", "(CYP1A2*1F)", "and", "-2464T-->delT", "(CYP1A2*1D)", "need", "to", "be", "analysed", "in", "the", "routine", "assessment", "of", "CYP1A2", "genotype;", "...
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(i) CYP1A2 polymorphisms are in linkage disequilibrium. Therefore, only -164A-->C (CYP1A2*1F) and -2464T-->delT (CYP1A2*1D) need to be analysed in the routine assessment of CYP1A2 genotype; (ii) in vivo CYP1A2 CYP1A2*1D ), -740T-->G (CYP1A2*1E and *1G), -164A-->C (CYP1A2*1F), 63C-->G (CYP1A2*2), and 1545T-->C (alleles ...
12534642
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
12534642
[ "In", "114", "samples,", "the", "most", "frequent", "CYP1A2", "CYP1A2*1E", "and", "*1G", "),", "-164A-->C", "(CYP1A2*1F),", "63C-->G", "(CYP1A2*2),", "and", "1545T-->C", "-164A-->C", " ", "(CYP1A2*1F),", "63C-->G", "(CYP1A2*2),", "and", "1545T-->C", "(alleles", "CYP...
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In 114 samples, the most frequent CYP1A2 CYP1A2*1E and *1G ), -164A-->C (CYP1A2*1F), 63C-->G (CYP1A2*2), and 1545T-->C -164A-->C (CYP1A2*1F), 63C-->G (CYP1A2*2), and 1545T-->C (alleles CYP1A2*1B, *1G, *1H and *3), using polymerase chain reaction-restriction fragment length polymorphism assays. All patients and contro...
12534642
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
12534642
[ "In", "114", "samples,", "the", "most", "frequent", "CYP1A2", "SNPs", "CYP1A2*1F", "),", "63C-->G", "(CYP1A2*2),", "and", "1545T-->C", "(alleles", "CYP1A2*1B,", "*1G,", "*1H", "and", "*3),", "using", "polymerase", "chain", "reaction-restriction", "fragment", "length...
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In 114 samples, the most frequent CYP1A2 SNPs CYP1A2*1F ), 63C-->G (CYP1A2*2), and 1545T-->C (alleles CYP1A2*1B, *1G, *1H and *3), using polymerase chain reaction-restriction fragment length polymorphism assays. All patients and controls were phenotyped for CYP1A2 by h.p.l.c. analysis of urinary caffeine metabolites.
12534642
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
12534642
[ "In", "114", "samples,", "the", "most", "frequent", "CYP1A2", "SNPs", "were", "1545T-->C", "63C-->G", " ", "(CYP1A2*2),", "and", "1545T-->C", "(alleles", "CYP1A2*1B,", "*1G,", "*1H", "and", "*3),", "using", "polymerase", "chain", "reaction-restriction", "fragment", ...
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In 114 samples, the most frequent CYP1A2 SNPs were 1545T-->C 63C-->G (CYP1A2*2), and 1545T-->C (alleles CYP1A2*1B, *1G, *1H and *3), using polymerase chain reaction-restriction fragment length polymorphism assays. All patients and controls were phenotyped for CYP1A2 by h.p.l.c. analysis of urinary caffeine metabolite...
12534642
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
12534642
[ "In", "114", "samples,", "the", "most", "frequent", "CYP1A2", "SNPs", "were", "1545T-->C", "(38.2%", "of", "tested", "chromosomes),", "-164A-->C", " ", "(", "CYP1A2*1F", "CYP1A2*2", "),", "and", "1545T-->C", "(alleles", "CYP1A2*1B,", "*1G,", "*1H", "and", "*3),"...
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In 114 samples, the most frequent CYP1A2 SNPs were 1545T-->C (38.2% of tested chromosomes), -164A-->C ( CYP1A2*1F CYP1A2*2 ), and 1545T-->C (alleles CYP1A2*1B, *1G, *1H and *3), using polymerase chain reaction-restriction fragment length polymorphism assays. All patients and controls were phenotyped for CYP1A2 by h.p...
12534642
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
12534642
[ "In", "114", "samples,", "the", "most", "frequent", "CYP1A2", "SNPs", "were", "1545T-->C", "(38.2%", "of", "tested", "chromosomes),", "-164A-->C", "(CYP1A2*1F,", "33.3%)", "and", "-2464T-->delT", " ", "(", "CYP1A2*1D", ",", "4.82%).", "The", "SNPs", " ", "were",...
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In 114 samples, the most frequent CYP1A2 SNPs were 1545T-->C (38.2% of tested chromosomes), -164A-->C (CYP1A2*1F, 33.3%) and -2464T-->delT ( CYP1A2*1D , 4.82%). The SNPs were in linkage disequilibrium: the most frequent constellations were found to be -3858G/-2464T/-740T/-164A/63C/1545T (61.8%), -3858G/-2464T/-74...
12534642
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
12534642
[ "(i)", "CYP1A2", "polymorphisms", "are", "in", "linkage", "disequilibrium.", "Therefore,", "only", "-164A-->C", " ", "(CYP1A2*1F)", "and", "-2464T-->delT", "(CYP1A2*1D)", "need", "to", "be", "analysed", "in", "the", "routine", "assessment", "of", "CYP1A2", "genotype...
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(i) CYP1A2 polymorphisms are in linkage disequilibrium. Therefore, only -164A-->C (CYP1A2*1F) and -2464T-->delT (CYP1A2*1D) need to be analysed in the routine assessment of CYP1A2 genotype; (ii) in vivo CYP1A2 activity is lower in colorectal cancer patients than in controls, and (iii) CYP1A2 genotype had no effect on...
12534642
[]
[]
8187091
[ "Characteristics", "of", "somatic", "mutation", "of", "the", "adenomatous", "polyposis", "coli", "gene", "in", "colorectal", "tumors." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.
8187091
[ "Mutation", "of", "the", "adenomatous", "polyposis", "coli", "(APC)", "gene", "was", "analyzed", "in", "500", "colorectal", "tumors", "from", "70", "familial", "adenomatous", "polyposis", "(FAP)", "and", "102", "non-FAP", "patients", "and", "in", "normal", "tiss...
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Mutation of the adenomatous polyposis coli (APC) gene was analyzed in 500 colorectal tumors from 70 familial adenomatous polyposis (FAP) and 102 non-FAP patients and in normal tissues from 119 FAP patients, using polymerase chain reaction-single-strand conformation polymorphism and direct sequencing methods. These tumo...
8187091
[ "Mutation", "of", "the", "adenomatous", "polyposis", "coli", "(APC)", "gene", "was", "analyzed", "in", "500", "colorectal", "tumors", "from", "70", "familial", "adenomatous", "polyposis", "(FAP)", "and", "102", "non-FAP", "patients", "and", "in", "normal", "tiss...
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Mutation of the adenomatous polyposis coli (APC) gene was analyzed in 500 colorectal tumors from 70 familial adenomatous polyposis (FAP) and 102 non-FAP patients and in normal tissues from 119 FAP patients, using polymerase chain reaction-single-strand conformation polymorphism and direct sequencing methods. These tumo...
8187091
[ "Mutation", "of", "the", "adenomatous", "polyposis", "coli", "(APC)", "gene", "was", "analyzed", "in", "500", "colorectal", "tumors", "from", "70", "familial", "adenomatous", "polyposis", "(FAP)", "and", "102", "non-FAP", "patients", "and", "in", "normal", "tiss...
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Mutation of the adenomatous polyposis coli (APC) gene was analyzed in 500 colorectal tumors from 70 familial adenomatous polyposis (FAP) and 102 non-FAP patients and in normal tissues from 119 FAP patients, using polymerase chain reaction-single-strand conformation polymorphism and direct sequencing methods. These tumo...
8187091
[]
[]
15946795
[ "GPX", "Pro198Leu", "and", "OGG1", "Ser326Cys", "polymorphisms", "and", "risk", "of", "development", "of", "colorectal", "adenomas", "and", "colorectal", "cancer." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer.
15946795
[ "Little", "is", "known", "about", "genetic", "risk", "factors", "for", "colorectal", "cancer.", "We", "assessed", "the", "association", "between", "polymorphisms", "in", "two", "genes", "involved", "in", "DNA", "repair", "of", "oxidative", "stress,", "GPX", "and...
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Little is known about genetic risk factors for colorectal cancer. We assessed the association between polymorphisms in two genes involved in DNA repair of oxidative stress, GPX and OGG1, and risk of colorectal carcinoma or adenomas. We studied 166 cases with adenocarcinoma, 974 with adenomas and 397 controls recruited ...
15946795
[ "Little", "is", "known", "about", "genetic", "risk", "factors", "for", "colorectal", "cancer.", "We", "assessed", "the", "association", "between", "polymorphisms", "polymorphisms", " ", "and", "risk", "of", "development", "of", "colorectal", "adenomas", "and", "co...
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Little is known about genetic risk factors for colorectal cancer. We assessed the association between polymorphisms polymorphisms and risk of development of colorectal adenomas and colorectal cancer.
15946795
[ "Little", "is", "known", "about", "genetic", "risk", "factors", "for", "colorectal", "cancer.", "We", "assessed", "the", "association", "between", "polymorphisms", "in", "two", "genes", "involved", "in", "DNA", "repair", "of", "oxidative", "stress,", "GPX", "and...
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Little is known about genetic risk factors for colorectal cancer. We assessed the association between polymorphisms in two genes involved in DNA repair of oxidative stress, GPX and OGG1, and risk of colorectal carcinoma or adenomas. We studied 166 cases with adenocarcinoma, 974 with adenomas and 397 controls recruited ...
15946795
[ "Little", "is", "known", "about", "genetic", "risk", "factors", "for", "colorectal", "cancer.", "We", "assessed", "the", "association", "between", "polymorphisms", "in", "two", "genes", "involved", "in", "DNA", "repair", "of", "oxidative", "stress,", "GPX", " ",...
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Little is known about genetic risk factors for colorectal cancer. We assessed the association between polymorphisms in two genes involved in DNA repair of oxidative stress, GPX and OGG1 , and risk of colorectal carcinoma or adenomas. We studied 166 cases with adenocarcinoma, 974 with adenomas and 397 controls recruit...
15946795
[]
[]
23584879
[ "Self", "administered", "screening", "for", "hereditary", "cancers", "in", "conjunction", "with", "mammography", "and", "ultrasound." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
Self administered screening for hereditary cancers in conjunction with mammography and ultrasound.
23584879
[ "We", "evaluated", "the", "feasibility", "of", "an", "automated", "tablet", "computer", "application", "providing", "a", "family", "and", "personal", "history", "based", "cancer", "risk", "assessment", "for", "hereditary", "breast,", "ovarian,", "endometrial", "and"...
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We evaluated the feasibility of an automated tablet computer application providing a family and personal history based cancer risk assessment for hereditary breast, ovarian, endometrial and colorectal cancers. 1,002 women presenting for screening mammography and 1,000 presenting for ultrasound were offered screening. T...
23584879
[]
[]
14734469
[ "BRAF", "mutation", "is", "frequently", "present", "in", "sporadic", "colorectal", "cancer", "with", "methylated", "hMLH1,", "but", "not", "in", "hereditary", "nonpolyposis", "colorectal", "cancer.", "\n\n\n", "##", "PURPOSE" ]
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BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer. ## PURPOSE
14734469
[ "The", "BRAF", "gene", "encodes", "a", "serine/threonine", "kinase", "and", "plays", "an", "important", "role", "in", "the", "mitogen-activated", "protein", "kinase", "signaling", "pathway.", "BRAF", "mutations", "in", "sporadic", "colorectal", "cancer", "with", "...
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The BRAF gene encodes a serine/threonine kinase and plays an important role in the mitogen-activated protein kinase signaling pathway. BRAF mutations in sporadic colorectal cancer with microsatellite instability (MSI) are more frequently detected than those in microsatellite stable cancer. In this study, we sought to c...
14734469
[ "##", "EXPERIMENTAL", "DESIGN" ]
[ 0, 0, 0 ]
## EXPERIMENTAL DESIGN
14734469
[ "We", "analyzed", "BRAF", "mutations", "in", "26", "colorectal", "cancer", "cell", "lines,", "80", "sporadic", "colorectal", "cancers,", "and", "20", "tumors", "from", "HNPCC", "patients", "by", "DNA", "sequencing", "and", "sequence-specific", "PCR.", "The", "me...
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We analyzed BRAF mutations in 26 colorectal cancer cell lines, 80 sporadic colorectal cancers, and 20 tumors from HNPCC patients by DNA sequencing and sequence-specific PCR. The methylation status of the hMLH1 gene was measured by either sequencing or restriction enzyme digestion after NaHSO(3) treatment.
14734469
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
14734469
[ "We", "observed", "a", "strong", "correlation", "of", "BRAF", "mutation", "with", "hMLH1", "promoter", "methylation.", "BRAF", "mutations", "were", "present", "in", "13", "of", "15", "(87%)", "of", "the", "colorectal", "cell", "lines", "and", "cancers", "with"...
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We observed a strong correlation of BRAF mutation with hMLH1 promoter methylation. BRAF mutations were present in 13 of 15 (87%) of the colorectal cell lines and cancers with methylated hMLH1, whereas only 4 of 91 (4%) of the cell lines and cancers with unmethylated hMLH1 carried the mutations (P < 0.00001). Sixteen of...
14734469
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
14734469
[ "We", "observed", "a", "strong", "correlation", "of", "BRAF", "mutation", "with", "hMLH1", "promoter", "methylation.", "BRAF", "mutations", "were", "present", "in", "13", "of", "15", "(87%)", "of", "the", "colorectal", "cell", "lines", "and", "cancers", "with"...
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We observed a strong correlation of BRAF mutation with hMLH1 promoter methylation. BRAF mutations were present in 13 of 15 (87%) of the colorectal cell lines and cancers with methylated hMLH1, whereas only 4 of 91 (4%) of the cell lines and cancers with unmethylated hMLH1 carried the mutations (P < 0.00001). Sixteen of...
14734469
[ "##", "EXPERIMENTAL", "DESIGN" ]
[ 0, 0, 0 ]
## EXPERIMENTAL DESIGN
14734469
[ "We", "analyzed", "BRAF", "mutations", "in", "26", "colorectal", "cancer", "cell", "lines,", "80", "sporadic", "colorectal", "cancers,", "and", "20", "tumors", "from", "HNPCC", "patients", "by", "DNA", "sequencing", "and", "sequence-specific", "PCR.", "The", "me...
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We analyzed BRAF mutations in 26 colorectal cancer cell lines, 80 sporadic colorectal cancers, and 20 tumors from HNPCC patients by DNA sequencing and sequence-specific PCR. The methylation status of the hMLH1 gene was measured by either sequencing or restriction enzyme digestion after NaHSO(3) treatment.
14734469
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
14734469
[ "We", "observed", "a", "strong", "correlation", "of", "BRAF", "mutations", " ", "in", "26", "colorectal", "cancer", "cell", "lines,", "80", "sporadic", "colorectal", "cancers,", "and", "20", "tumors", "from", "HNPCC", "patients", "by", "DNA", "sequencing", "an...
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We observed a strong correlation of BRAF mutations in 26 colorectal cancer cell lines, 80 sporadic colorectal cancers, and 20 tumors from HNPCC patients by DNA sequencing and sequence-specific PCR. The methylation status of the hMLH1 gene was measured by either sequencing or restriction enzyme digestion after NaHSO...
14734469
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
14734469
[ "We", "observed", "a", "strong", "correlation", "of", "BRAF", "mutation", "with", "hMLH1", "promoter", "methylation.", "BRAF", "mutations", "were", "present", "in", "13", "of", "15", "(87%)", "of", "the", "colorectal", "cell", "lines", "and", "cancers", "with"...
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We observed a strong correlation of BRAF mutation with hMLH1 promoter methylation. BRAF mutations were present in 13 of 15 (87%) of the colorectal cell lines and cancers with methylated hMLH1, whereas only 4 of 91 (4%) of the cell lines and cancers with unmethylated hMLH1 carried the mutations (P < 0.00001). Sixteen of...
14734469
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
14734469
[ "BRAF", "mutations", "are", "frequently", "present", "in", "sporadic", "colorectal", "cancer", "with", "methylated", "methylated", " ", "hMLH1,", "whereas", "only", "4", "of", "91", "(4%)", "of", "the", "cell", "lines", "and", "cancers", "with", "unmethylated", ...
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BRAF mutations are frequently present in sporadic colorectal cancer with methylated methylated hMLH1, whereas only 4 of 91 (4%) of the cell lines and cancers with unmethylated hMLH1 carried the mutations (P < 0.00001). Sixteen of 17 mutations were at residue 599 methylated hMLH1, but not in hereditary nonpolyposi...
14734469
[ "The", "BRAF", "gene", "encodes", "a", "serine/threonine", "kinase", "and", "plays", "an", "important", "role", "in", "the", "mitogen-activated", "protein", "kinase", "signaling", "pathway.", "BRAF", "mutations", "in", "sporadic", "colorectal", "cancer", "with", "...
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The BRAF gene encodes a serine/threonine kinase and plays an important role in the mitogen-activated protein kinase signaling pathway. BRAF mutations in sporadic colorectal cancer with microsatellite instability (MSI) are more frequently detected than those in microsatellite stable cancer. In this study, we sought to c...
14734469
[ "##", "EXPERIMENTAL", "DESIGN" ]
[ 0, 0, 0 ]
## EXPERIMENTAL DESIGN
14734469
[ "We", "analyzed", "BRAF", "mutations", "in", "26", "colorectal", "cancer", "cell", "lines,", "80", "sporadic", "colorectal", "cancers,", "and", "20", "tumors", "from", "HNPCC", "patients", "by", "DNA", "sequencing", "and", "sequence-specific", "PCR.", "The", "me...
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We analyzed BRAF mutations in 26 colorectal cancer cell lines, 80 sporadic colorectal cancers, and 20 tumors from HNPCC patients by DNA sequencing and sequence-specific PCR. The methylation status of the hMLH1 gene was measured by either sequencing or restriction enzyme digestion after NaHSO(3) treatment.
14734469
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
14734469
[ "We", "observed", "a", "strong", "correlation", "of", "BRAF", "mutation", "with", "hMLH1", "promoter", "methylation.", "BRAF", "mutations", "were", "present", "in", "13", "of", "15", "(87%)", "of", "the", "colorectal", "cell", "lines", "and", "cancers", "with"...
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We observed a strong correlation of BRAF mutation with hMLH1 promoter methylation. BRAF mutations were present in 13 of 15 (87%) of the colorectal cell lines and cancers with methylated hMLH1, whereas only 4 of 91 (4%) of the cell lines and cancers with unmethylated hMLH1 carried the mutations (P < 0.00001). Sixteen of...
14734469
[ "##", "EXPERIMENTAL", "DESIGN" ]
[ 0, 0, 0 ]
## EXPERIMENTAL DESIGN
14734469
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We analyzed BRAF mutations in 26 colorectal cancer cell lines, 80 sporadic colorectal cancers, and 20 tumors from HNPCC patients by DNA sequencing and sequence-specific PCR. The methylation status of the hMLH1 gene was measured by either sequencing or restriction enzyme digestion after NaHSO(3) treatment.
14734469
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
14734469
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We observed a strong correlation of BRAF mutation with hMLH1 promoter methylation. BRAF mutations were present in 13 of 15 (87%) of the colorectal cell lines and cancers with methylated hMLH1, whereas only 4 of 91 (4%) of the cell lines and cancers with unmethylated hMLH1 carried the mutations (P < 0.00001). Sixteen of...
14734469
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
14734469
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We observed a strong correlation of BRAF mutation with hMLH1 promoter methylation . BRAF mutations were present in 13 of 15 (87%) of the colorectal cell lines and cancers with methylated hMLH1, whereas only 4 of 91 (4%) of the cell lines and cancers with unmethylated hMLH1 carried the mutations (P < 0.00001). Sixteen o...
14734469
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
14734469
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BRAF mutations BRAF mutations were present in 13 of 15 (87%) of the colorectal cell lines and cancers with methylated hMLH1, whereas only 4 of 91 (4%) of the cell lines and cancers with unmethylated hMLH1 carried the mutations (P < 0.00001). Sixteen of 17 mutations were at residue 599 (V599E). A BRAF mutation was als...
14734469
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
14734469
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BRAF hMLH1 , whereas only 4 of 91 (4%) of the cell lines and cancers with unmethylated hMLH1 carried the mutations (P < 0.00001). Sixteen of 17 mutations were at residue 599 (V599E). A BRAF mutation was also identified at residue 463 (G463V) in one cell line. In addition, BRAF mutations were not found in any cancers or...
14734469
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
14734469
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BRAF mutations are frequently present in sporadic colorectal cancer with methylated hMLH1 mutations (P < 0.00001). Sixteen of 17 mutations were at residue 599 (V599E). A BRAF mutation was also identified at residue 463 (G463V) in one cell line. In addition, BRAF mutations were not found in any cancers or cell lines w...
14734469
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
14734469
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BRAF mutations are frequently present in sporadic colorectal cancer with methylated hMLH1, but not in HNPCC-related cancers. This discrepancy of BRAF mutations hMLH1 carried the mutations (P < 0.00001). Sixteen of 17 mutations were at residue 599 (V599E). A BRAF mutation was also identified at residue 463 (G463V) i...
14734469
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
14734469
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BRAF mutations are frequently present in sporadic colorectal cancer with methylated hMLH1, but not in HNPCC-related cancers. This discrepancy of BRAF mutation BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer. ## PURPOSE