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README.md
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license: openrail
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---
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license: openrail
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language:
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- en
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tags:
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- RNA
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- biology
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- generative
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- foundation-model
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- language-model
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- sequence-design
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pipeline_tag: text-generation
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---
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# EVA: Evolutionary Versatile Architect
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EVA is a generative foundation model for universal RNA modeling and design,
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trained on **RNAVerse v1** — a curated atlas of **114 million full-length RNA
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sequences** spanning all domains of life.
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## Model Description
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| Property | Details |
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|----------|---------|
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| Architecture | Decoder-only Transformer + Mixture-of-Experts (MoE) |
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| Parameters | 1.4B (also available: 21M, 167M, 470M) |
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| Context Window | 8,192 tokens |
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| Training Data | 114M full-length RNA sequences (RNAVerse v1) |
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| Training Objectives | Causal LM (CLM) + Generalized LM (GLM), 2:1 ratio |
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| Conditioning | RNA type tags + taxonomic lineage tags |
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## Capabilities
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**🔬 Zero-shot Fitness Prediction**
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Predicts mutational effects across RNA, DNA gene regions, and proteins
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using evolutionary likelihood — no fine-tuning required.
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**🧬 Controllable RNA Generation**
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Supports de novo generation and targeted region redesign across 11 RNA
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classes: mRNA, lncRNA, circRNA, tRNA, rRNA, miRNA, piRNA, sRNA, snRNA,
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snoRNA, and viral RNA.
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**💉 Vaccine Design**
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Species-aware codon optimization for mRNA and circRNA vaccines;
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de novo IRES redesign via GLM masked infilling.
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**🦠 Functional RNA Engineering**
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Fine-tuning-ready for tRNA design, RNA aptamer optimization, and
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CRISPR guide RNA (omegaRNA) generation.
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## Usage
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# Coming soon
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