yurakuratov
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upd readme.md, renaming to gena-lm
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README.md
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- human_genome
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---
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#
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Differences between
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- BPE tokenization instead of k-mers;
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- input sequence size is about 3000 nucleotides (512 BPE tokens) compared to 510 nucleotides of DNABERT
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- pre-training on T2T vs. GRCh38.p13 human genome assembly.
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Source code and data: https://github.com/AIRI-Institute/
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## Examples
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### How to load the model to fine-tune it on classification task
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```python
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from src.
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from transformers import AutoTokenizer
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tokenizer = AutoTokenizer.from_pretrained('AIRI-Institute/
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model = BertForSequenceClassification.from_pretrained('AIRI-Institute/
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```
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## Model description
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- 512 Maximum sequence length
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- 12 Layers, 12 Attention heads
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- 768 Hidden size
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- 32k Vocabulary size
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We pre-trained
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## Downstream tasks
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Currently,
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### Fine-tuning
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After fine-tuning
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| model
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| DeePromoter
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| BigBird
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We can conclude that our model achieves comparable performance to the previously published results for promoter prediction task.
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- human_genome
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---
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# GENA-LM
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GENA-LM is a transformer masked language model trained on human DNA sequence.
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Differences between GENA-LM and DNABERT:
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- BPE tokenization instead of k-mers;
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- input sequence size is about 3000 nucleotides (512 BPE tokens) compared to 510 nucleotides of DNABERT
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- pre-training on T2T vs. GRCh38.p13 human genome assembly.
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Source code and data: https://github.com/AIRI-Institute/GENA-LM
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## Examples
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### How to load the model to fine-tune it on classification task
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```python
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from src.gena_lm.modeling_bert import BertForSequenceClassification
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from transformers import AutoTokenizer
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tokenizer = AutoTokenizer.from_pretrained('AIRI-Institute/gena-lm-bert-base')
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model = BertForSequenceClassification.from_pretrained('AIRI-Institute/gena-lm-bert-base')
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```
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## Model description
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GENA-LM model is trained in a masked language model (MLM) fashion, following the methods proposed in the BigBird paper by masking 85% of tokens. Model config for `gena-lm-bert-base` is similar to the bert-base:
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- 512 Maximum sequence length
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- 12 Layers, 12 Attention heads
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- 768 Hidden size
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- 32k Vocabulary size
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We pre-trained `gena-lm-bert-base` using the latest T2T human genome assembly (https://www.ncbi.nlm.nih.gov/assembly/GCA_009914755.3/). Pre-training was performed for 500,000 iterations with the same parameters as in BigBird, except sequence length was equal to 512 tokens and we used pre-layer normalization in Transformer.
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## Downstream tasks
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Currently, gena-lm-bert-base model has been finetuned and tested on promoter prediction task. Its' performance is comparable to previous SOTA results. We plan to fine-tune and make available models for other downstream tasks in the near future.
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### Fine-tuning GENA-LM on our data and scoring
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After fine-tuning gena-lm-bert-base on promoter prediction dataset, following results were achieved:
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| model | seq_len (bp) | F1 |
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|--------------------------|--------------|-------|
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| DeePromoter | 300 | 95.60 |
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| GENA-LM bert-base (ours) | 2000 | 95.72 |
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| BigBird | 16000 | 99.90 |
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We can conclude that our model achieves comparable performance to the previously published results for promoter prediction task.
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