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| 10322,uh the physics simulation engine that's that's often used for robotics research | |
| 10328,and so on so i think that's a pretty gangster move uh so what what's the | |
| 10333,what's i mean this uh very few companies or people would do | |
| 10338,that kind of thing what's the philosophy behind that you know it's a case-by-case basis and in both those cases we felt | |
| 10344,that was the maximum benefit to humanity to do that and and the scientific community in one case the robotics uh | |
| 10351,physics community with mojoco so purchased it we purchased to obs we purchased it for the express | |
| 10357,principle to open source it so um so you know i hope people appreciate that | |
| 10402,it's great to hear that you do and then the second thing was and mostly we did it because the person building it is uh | |
| 10408,uh would not it was not able to cope with supporting it anymore because it was it got too big for him his amazing | |
| 10414,professor uh who who built it in the first place so we helped him out with that and then with alpha folds even | |
| 10419,bigger i would say and i think in that case we decided that there were so many downstream applications of alpha fold um | |
| 10427,that we couldn't possibly even imagine what they all were so the best way to accelerate uh drug discovery and also | |
| 10434,fundamental research would be to to um give all that data away and and and the | |
| 10440,and the and the system itself um you know it's been so gratifying to see what people have done that within just one | |
| 10446,year which is a short amount of time in science and uh it's been used by over 500 000 researchers have used it we | |
| 10454,think that's almost every biologist in the world i think there's roughly 500 000 biologists in the world professional biologists have used it to to look at | |
| 10501,their proteins of interest we've seen amazing fundamental research done so a couple of weeks ago front | |
| 10508,cover there was a whole special issue of science including the front cover which had the nuclear pore complex on it which | |
| 10514,is one of the biggest proteins in the body the nuclear poor complex is a protein that governs all the nutrients | |
| 10519,going in and out of your cell nucleus so they're like little hole gateways that open and close to let things go in and | |
| 10525,out of your cell nucleus so they're really important but they're huge because they're massive doughnut rings shaped things and they've been looking | |
| 10532,to try and figure out that structure for decades and they have lots of you know experimental data but it's too low | |
| 10537,resolution there's bits missing and they were able to like a giant lego jigsaw puzzle use alpha fold predictions plus | |
| 10544,experimental data and combined those two independent sources of information uh actually four different groups around | |
| 10550,the world were able to put it together the sec more or less simultaneously using alpha fault predictions so that's | |
| ID,Texts | |
| 10556,been amazing to see and pretty much every pharma company every drug company executive i've spoken to has said that | |
| 10601,their teams are using alpha fold to accelerate whatever drugs uh uh they're | |
| 10606,trying to discover so i think the knock-on effect has been enormous in terms of uh the impact that uh | |
| 10614,alpha-fold has made and it's probably bringing in it's creating biologists it's bringing more people into the field | |
| 10619,um both on the excitement and both on the technical skills involved and um | |
| 10625,it's almost like uh a gateway drug to biology yes it is you get more computational people involved too | |
| 10631,hopefully and and i think for us you know the next stage as i said you know in future we have to have other | |
| 10637,considerations too we're building on top of alpha fold and these other ideas i discussed with you about protein protein interactions and and genomics and other | |
| 10644,things and not everything will be open source some of it will will do commercially because that will be the best way to actually get the most | |
| 10649,resources and impact behind it in other ways some other projects will do non-profit style um and also we have to | |
| 10656,consider for future things as well safety and ethics as well like but you know synthetic biology there are you | |
| 10702,know there is dual use and we have to think about that as well with alpha fold we you know we consulted with 30 | |
| 10707,different bioethicists and and other people expert in this field to make sure it was safe before um we released it so | |
| 10713,there'll be other considerations in future but for right now you know i think alpha fold is a kind of a gift from us to to to the scientific | |
| 10720,community so i'm pretty sure that something like alpha fold | |
| 10725,uh would be part of nobel prizes in the future but us humans of course are horrible | |
| 10731,with credit assignment so we'll of course give it to the humans do you think there will be a day | |
| 10737,when ai system can't be denied that it earned that nobel prize do you | |
| 10745,think we'll see that in 21st century it depends what type of ais we end up building right whether they're um | |
| 10752,you know goal seeking agents who specifies the goals uh who comes up with the hypotheses | |
| 10757,who you know who determines which problems to tackle right so i think it's about an announcement yeah so it's | |
| 10802,announcing the results exactly as part of it um so i think right now of course it's it's it's it's amazing human | |
| 10810,ingenuity that's behind these systems and then the system in my opinion is just a tool you know it'd be a bit like | |
| 10815,saying with galileo and his telescope you know the ingenuity the the the credit should go to the telescope i mean | |
| 10821,it's clearly galileo building the tool which he then uses so i still see that in the same way | |
| 10826,today even though these tools learn for themselves um they're i think i think of things like alpha fold and that the | |
| 10833,things we're building as the ultimate tools for science and for acquiring new knowledge to help us as scientists | |
| 10839,acquire new knowledge i think one day there will come a point where an ai system may solve or come up with | |
| 10846,something like general relativity of its own bat not just by averaging everything on the internet or | |
| 10852,averaging everything on pubmed although that would be interesting to see what that would come up with um so |