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README.md
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**Cell-wise Coefficient of Variation**:
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| Metric | Training Value | Validation Value |
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| Mean Absolute Error | 0.57 | 0.57 |
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| Pearson Correlation | 0.76 | 0.75 |
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| Spearman Correlation | 0.83 | 0.83 |
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| R² (R-Squared) | -0.10 | -0.09 |
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Modality: protein
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| Metric | Training Value | Validation Value |
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| Mean Absolute Error | 0.32 | 0.32 |
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| Pearson Correlation | 0.53 | 0.53 |
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| Spearman Correlation | 0.78 | 0.78 |
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| R² (R-Squared) | -1.45 | -1.43 |
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The gene-wise coefficient of variation summarizes how well variation between different genes is
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preserved by the generated model expression. This value is usually quite high.
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**Gene-wise Coefficient of Variation**:
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| Metric | Training Value |
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| Mean Absolute Error | 26.96 |
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| Pearson Correlation | 0.95 |
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| Spearman Correlation | 0.99 |
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| R² (R-Squared) | -0.25 |
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Modality: protein
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| Metric | Training Value |
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| Mean Absolute Error | 4.29 |
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| Pearson Correlation | 0.42 |
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| Spearman Correlation | 0.73 |
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| R² (R-Squared) | -6.32 |
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</details>
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**Differential expression**:
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| Index | gene_f1 | lfc_mae | lfc_pearson | lfc_spearman | roc_auc | pr_auc | n_cells |
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| --- | --- | --- | --- | --- | --- | --- | --- |
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| CD14-positive monocyte | 0.94 | 2.13 | 0.59 | 0.91 | 0.09 | 0.02 | 120843.00 |
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| CD16-positive, CD56-dim natural killer cell, human | 0.95 | 2.34 | 0.46 | 0.83 | 0.09 | 0.02 | 92848.00 |
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| naive thymus-derived CD4-positive, alpha-beta T cell | 0.90 | 2.75 | 0.39 | 0.76 | 0.09 | 0.02 | 63096.00 |
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| effector CD8-positive, alpha-beta T cell | 0.87 | 3.49 | 0.39 | 0.73 | 0.07 | 0.02 | 53534.00 |
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| central memory CD4-positive, alpha-beta T cell | 0.94 | 2.52 | 0.38 | 0.75 | 0.06 | 0.02 | 49904.00 |
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| naive B cell | 0.93 | 3.21 | 0.43 | 0.73 | 0.08 | 0.02 | 44136.00 |
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| naive thymus-derived CD8-positive, alpha-beta T cell | 0.92 | 3.47 | 0.39 | 0.65 | 0.06 | 0.02 | 31175.00 |
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| mature NK T cell | 0.91 | 3.70 | 0.42 | 0.63 | 0.04 | 0.01 | 21673.00 |
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| effector memory CD8-positive, alpha-beta T cell | 0.83 | 4.48 | 0.36 | 0.55 | 0.07 | 0.02 | 18917.00 |
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| T-helper 22 cell | 0.90 | 3.98 | 0.42 | 0.61 | 0.06 | 0.02 | 18379.00 |
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| gamma-delta T cell | 0.86 | 4.59 | 0.38 | 0.50 | 0.05 | 0.01 | 15942.00 |
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| platelet | 0.89 | 4.43 | 0.51 | 0.66 | 0.06 | 0.02 | 15847.00 |
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| T follicular helper cell | 0.93 | 4.43 | 0.42 | 0.54 | 0.06 | 0.02 | 13608.00 |
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| mucosal invariant T cell | 0.87 | 5.03 | 0.40 | 0.45 | 0.05 | 0.02 | 10992.00 |
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| CD16-negative, CD56-bright natural killer cell, human | 0.85 | 5.21 | 0.40 | 0.46 | 0.05 | 0.02 | 10442.00 |
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| class switched memory B cell | 0.89 | 5.24 | 0.44 | 0.49 | 0.08 | 0.02 | 7244.00 |
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| immature B cell | 0.89 | 5.50 | 0.46 | 0.46 | 0.09 | 0.02 | 5238.00 |
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| natural killer cell | 0.89 | 5.36 | 0.44 | 0.43 | 0.09 | 0.02 | 4963.00 |
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| plasmacytoid dendritic cell | 0.91 | 5.18 | 0.46 | 0.46 | 0.05 | 0.02 | 4612.00 |
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| CD14-low, CD16-positive monocyte | 0.91 | 4.32 | 0.58 | 0.59 | 0.10 | 0.02 | 4140.00 |
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| plasmablast | 0.82 | 5.05 | 0.51 | 0.54 | 0.10 | 0.02 | 4121.00 |
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| IgG plasma cell | 0.69 | 5.20 | 0.49 | 0.51 | 0.14 | 0.01 | 3527.00 |
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| dendritic cell, human | 0.84 | 5.18 | 0.43 | 0.43 | 0.62 | 0.20 | 3357.00 |
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| unswitched memory B cell | 0.92 | 5.41 | 0.46 | 0.43 | 0.18 | 0.02 | 3285.00 |
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| myeloid dendritic cell | 0.82 | 5.29 | 0.49 | 0.47 | 0.14 | 0.02 | 3243.00 |
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| B cell | 0.86 | 5.34 | 0.48 | 0.44 | 0.20 | 0.02 | 3024.00 |
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| IgA plasma cell | 0.70 | 5.21 | 0.50 | 0.49 | 0.13 | 0.02 | 2699.00 |
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| effector memory CD4-positive, alpha-beta T cell | 0.89 | 5.33 | 0.46 | 0.38 | 0.13 | 0.02 | 2634.00 |
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| malignant cell | 0.93 | 5.74 | 0.44 | 0.40 | 0.32 | 0.02 | 2291.00 |
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| CD34-positive, CD38-negative hematopoietic stem cell | 0.78 | 5.51 | 0.48 | 0.49 | 0.11 | 0.02 | 2238.00 |
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| erythrocyte | 0.79 | 5.67 | 0.40 | 0.25 | 0.62 | 0.33 | 2232.00 |
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| CD8-positive, alpha-beta T cell | 0.84 | 5.01 | 0.51 | 0.43 | 0.35 | 0.03 | 1355.00 |
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| IgM plasma cell | 0.78 | 4.62 | 0.54 | 0.51 | 0.28 | 0.02 | 1163.00 |
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| ILC1, human | 0.81 | 4.58 | 0.52 | 0.45 | 0.39 | 0.03 | 776.00 |
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| erythroid progenitor cell, mammalian | 0.71 | 5.58 | 0.50 | 0.46 | 0.34 | 0.02 | 773.00 |
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| monocyte | 0.88 | 4.17 | 0.57 | 0.51 | 0.37 | 0.02 | 649.00 |
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| CD4-positive, alpha-beta T cell | 0.82 | 4.63 | 0.54 | 0.49 | 0.33 | 0.02 | 624.00 |
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| dendritic cell | 0.76 | 5.16 | 0.50 | 0.42 | 0.45 | 0.03 | 585.00 |
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| T-helper 1 cell | 0.83 | 3.91 | 0.58 | 0.54 | 0.29 | 0.02 | 481.00 |
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| regulatory T cell | 0.76 | 3.91 | 0.56 | 0.53 | 0.32 | 0.02 | 329.00 |
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| hematopoietic precursor cell | 0.70 | 4.55 | 0.58 | 0.54 | 0.26 | 0.02 | 180.00 |
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| group 2 innate lymphoid cell, human | 0.65 | 3.00 | 0.59 | 0.63 | 0.27 | 0.02 | 93.00 |
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| T-helper 2 cell | 0.67 | 2.79 | 0.61 | 0.67 | 0.19 | 0.02 | 55.00 |
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| myeloid lineage restricted progenitor cell | 0.53 | 3.95 | 0.52 | 0.56 | 0.32 | 0.02 | 53.00 |
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| megakaryocyte | 0.70 | 3.62 | 0.62 | 0.61 | 0.30 | 0.02 | 53.00 |
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| T-helper 17 cell | 0.48 | 2.54 | 0.53 | 0.69 | 0.21 | 0.02 | 13.00 |
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Modality: protein
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| Index | gene_f1 | lfc_mae | lfc_pearson | lfc_spearman | roc_auc | pr_auc | n_cells |
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| --- | --- | --- | --- | --- | --- | --- | --- |
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| CD14-positive monocyte | 0.95 | 0.07 | 1.00 | 0.99 | 0.26 | 0.12 | 120843.00 |
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| CD16-positive, CD56-dim natural killer cell, human | 0.95 | 0.06 | 0.99 | 0.98 | 0.22 | 0.12 | 92848.00 |
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| naive thymus-derived CD4-positive, alpha-beta T cell | 0.84 | 0.06 | 0.99 | 0.98 | 0.37 | 0.13 | 63096.00 |
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| effector CD8-positive, alpha-beta T cell | 0.95 | 0.05 | 0.99 | 0.97 | 0.17 | 0.09 | 53534.00 |
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| central memory CD4-positive, alpha-beta T cell | 1.00 | 0.06 | 1.00 | 0.99 | 0.33 | 0.12 | 49904.00 |
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| naive B cell | 1.00 | 0.08 | 1.00 | 0.96 | 0.20 | 0.12 | 44136.00 |
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| naive thymus-derived CD8-positive, alpha-beta T cell | 0.95 | 0.07 | 0.99 | 0.95 | 0.13 | 0.08 | 31175.00 |
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| mature NK T cell | 0.89 | 0.06 | 0.99 | 0.98 | 0.21 | 0.10 | 21673.00 |
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| effector memory CD8-positive, alpha-beta T cell | 0.84 | 0.05 | 0.99 | 0.98 | 0.06 | 0.11 | 18917.00 |
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| T-helper 22 cell | 0.95 | 0.06 | 0.99 | 0.98 | 0.11 | 0.08 | 18379.00 |
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| gamma-delta T cell | 0.89 | 0.07 | 0.97 | 0.94 | 0.26 | 0.18 | 15942.00 |
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| platelet | 0.79 | 0.10 | 0.97 | 0.94 | 0.21 | 0.11 | 15847.00 |
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| T follicular helper cell | 1.00 | 0.07 | 0.99 | 0.98 | 0.24 | 0.12 | 13608.00 |
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| mucosal invariant T cell | 0.89 | 0.08 | 0.97 | 0.95 | 0.15 | 0.09 | 10992.00 |
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| CD16-negative, CD56-bright natural killer cell, human | 0.95 | 0.08 | 0.98 | 0.95 | 0.45 | 0.47 | 10442.00 |
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| class switched memory B cell | 0.89 | 0.09 | 0.99 | 0.96 | 0.11 | 0.12 | 7244.00 |
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| immature B cell | 0.89 | 0.12 | 0.98 | 0.94 | 0.26 | 0.14 | 5238.00 |
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| natural killer cell | 0.74 | 0.06 | 0.99 | 0.98 | 0.68 | 0.68 | 4963.00 |
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| plasmacytoid dendritic cell | 0.84 | 0.09 | 0.98 | 0.96 | 0.54 | 0.56 | 4612.00 |
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| CD14-low, CD16-positive monocyte | 0.84 | 0.08 | 0.99 | 0.98 | 0.58 | 0.23 | 4140.00 |
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| plasmablast | 0.79 | 0.08 | 0.99 | 0.97 | 0.47 | 0.49 | 4121.00 |
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| IgG plasma cell | 0.89 | 0.09 | 0.98 | 0.94 | 0.47 | 0.51 | 3527.00 |
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| dendritic cell, human | 0.79 | 0.10 | 0.98 | 0.90 | 0.94 | 0.90 | 3357.00 |
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| unswitched memory B cell | 0.95 | 0.10 | 0.99 | 0.96 | 0.63 | 0.61 | 3285.00 |
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| myeloid dendritic cell | 0.89 | 0.11 | 0.97 | 0.94 | 0.74 | 0.74 | 3243.00 |
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| B cell | 0.89 | 0.10 | 0.98 | 0.93 | 0.58 | 0.59 | 3024.00 |
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| IgA plasma cell | 0.89 | 0.10 | 0.97 | 0.91 | 0.47 | 0.48 | 2699.00 |
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| effector memory CD4-positive, alpha-beta T cell | 0.95 | 0.08 | 0.99 | 0.95 | 0.79 | 0.79 | 2634.00 |
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| malignant cell | 0.89 | 0.09 | 0.99 | 0.98 | 0.17 | 0.08 | 2291.00 |
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| CD34-positive, CD38-negative hematopoietic stem cell | 0.74 | 0.10 | 0.96 | 0.93 | 0.37 | 0.36 | 2238.00 |
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| erythrocyte | 0.84 | 0.08 | 0.99 | 0.98 | 0.21 | 0.25 | 2232.00 |
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| CD8-positive, alpha-beta T cell | 0.68 | 0.09 | 0.87 | 0.87 | 0.69 | 0.54 | 1355.00 |
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| IgM plasma cell | 0.95 | 0.09 | 0.98 | 0.92 | 0.42 | 0.46 | 1163.00 |
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| ILC1, human | 0.84 | 0.10 | 0.96 | 0.88 | 0.53 | 0.55 | 776.00 |
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| erythroid progenitor cell, mammalian | 0.58 | 0.15 | 0.94 | 0.92 | 0.22 | 0.22 | 773.00 |
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| monocyte | 0.79 | 0.09 | 0.98 | 0.96 | 0.69 | 0.70 | 649.00 |
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| CD4-positive, alpha-beta T cell | 0.89 | 0.11 | 0.96 | 0.83 | 0.58 | 0.59 | 624.00 |
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| dendritic cell | 0.74 | 0.20 | 0.83 | 0.80 | 0.52 | 0.41 | 585.00 |
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| T-helper 1 cell | 0.95 | 0.10 | 0.98 | 0.95 | 0.73 | 0.73 | 481.00 |
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| regulatory T cell | 0.89 | 0.14 | 0.97 | 0.94 | 0.89 | 0.85 | 329.00 |
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| hematopoietic precursor cell | 0.63 | 0.28 | 0.29 | 0.88 | 0.36 | 0.28 | 180.00 |
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| group 2 innate lymphoid cell, human | 0.63 | 0.25 | 0.98 | 0.53 | 0.33 | 0.36 | 93.00 |
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| T-helper 2 cell | 0.68 | 0.28 | 0.88 | 0.73 | 0.74 | 0.65 | 55.00 |
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| myeloid lineage restricted progenitor cell | 0.32 | 0.27 | 0.98 | 0.80 | 0.54 | 0.26 | 53.00 |
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| megakaryocyte | 0.63 | 0.23 | 0.98 | 0.81 | 0.57 | 0.52 | 53.00 |
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| T-helper 17 cell | 0.68 | 0.53 | 0.70 | 0.74 | 0.48 | 0.36 | 13.00 |
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</details>
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**Cell-wise Coefficient of Variation**:
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The gene-wise coefficient of variation summarizes how well variation between different genes is
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preserved by the generated model expression. This value is usually quite high.
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**Gene-wise Coefficient of Variation**:
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</details>
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**Differential expression**:
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</details>
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