README.md

metadata

license: mit
tags:
  - Hi-C
  - deep-learning
  - chromatin-loop-detection
  - biology
  - 3D-genomics

A Versatile Framework for Chromatin Loop Annotation in Bulk and Single-cell Hi-C Data

See https://github.com/ai4nucleome/Polaris for more details.

🌟 Polaris is a versatile and efficient command line tool tailored for rapid and accurate chromatin loop detectionfrom from contact maps generated by various assays, including bulk Hi-C, scHi-C, Micro-C, and DNA SPRITE. Polaris is particularly well-suited for analyzing sparse scHi-C data and low-coverage datasets.

📝Documentation

Detailed documentation can be found at: Polaris Doc.

Citation:

Yusen Hou, Audrey Baguette, Mathieu Blanchette*, & Yanlin Zhang*. A versatile tool for chromatin loop annotation in bulk and single-cell Hi-C data. bioRxiv, 2024. Paper

@article {Hou2024Polaris,
    title = {A versatile tool for chromatin loop annotation in bulk and single-cell Hi-C data},
    author = {Yusen Hou, Audrey Baguette, Mathieu Blanchette, and Yanlin Zhang},
    journal = {bioRxiv}
    year = {2024},
}

📩 Contact

A GitHub issue is preferable for all problems related to using Polaris.

For other concerns, please email Yusen Hou or Yanlin Zhang (yhou925@connect.hkust-gz.edu.cn, yanlinzhang@hkust-gz.edu.cn).