brussels airlines melayani destinasi berikut ini (termasuk virgin express dan sn brussels airlines):
luanda (bandar udara quatro de fevereiro)
bujumbura (bandar udara internasional bujumbura)
banjul (bandar udara internasional banjul)
conakry (bandar udara internasional conakry)
douala (bandar udara douala)
yaound (bandar udara internasional yaound nsimalen)
nairobi (bandar udara internasional jomo kenyatta)
monrovia (bandar udara internasional roberts)
casablanca (bandar udara internasional mohammed v)
abidjan (bandar udara port bouet)
republik demokratik kongo
kinshasa (bandar udara internasional kinshasa)
kigali (bandar udara internasional kigali)
dakar (bandar udara internasional dakar-yoff-lopold sdar senghor)
freetown (bandar udara internasional fungi)
entebbe (bandar udara internasional entebbe)
beijing (bandar udara beijing capital)
tel aviv (bandar udara internasional ben gurion)
istanbul (bandar udara internasional atatrk)
uni emirat arab
abu dhabi (bandar udara internasional abu dhabi)
vienna (bandar udara internasional vienna)
brussels (bandar udara brussels) hub
birmingham (bandar udara internasional birmingham)
bristol (bandar udara bristol)
london (bandar udara london gatwick)
manchester (bandar udara manchester)
newcastle (bandar udara newcastle)
copenhagen (bandar udara copenhagen)
helsinki (bandar udara helsinki-vantaa)
budapest (bandar udara internasional budapest ferihegy)
bari (bandar udara palese macchie)
bologna (bandar udara internasional guglielmo marconi)
cagliari (bandar udara cagliari) [april 2007]
catania (bandar udara catania-fontanarossa)
florence (bandar udara amerigo vespucci)
(bandar udara internasional malpensa)
(bandar udara internasional orio al serio)
palermo (bandar udara falcone-borsellino)
roma (bandar udara internasional leonardo da vinci)
turin (bandar udara internasional turin)
venesia (bandar udara internasional marco polo)
(bandar udara internasional berlin-schnefeld)
(bandar udara internasional tempelhof)
frankfurt (bandar udara internasional frankfurt)
hamburg (bandar udara hamburg)
munich (bandar udara internasional munich)
oslo (bandar udara oslo, gardermoen)
lyon (bandar udara internasional saint-exupry)
marseille (bandar udara marseille provence)
nice (bandar udara internasional cte d'azur)
paris (bandar udara charles de gaulle)
strasbourg (bandar udara strasbourg)
toulouse (bandar udara internasional toulouse blagnac)
krakw (bandar udara internasional john paul ii)
warsawa (bandar udara warsaw frederic chopin)
faro (bandar udara faro)
lisbon (bandar udara portela)
porto (bandar udara francisco s carneiro)
praha (bandar udara internasional ruzyn)
moskow (bandar udara internasional domodedovo)
st. petersburg (bandar udara pulkovo) [28 april 2007]
barcelona (bandar udara internasional barcelona)
bilbao (bandar udara bilbao)
madrid (bandar udara internasional madrid barajas)
malaga (bandar udara malaga)
murcia (bandar udara murcia)
palma (bandar udara palma)
seville (bandar udara internasional san pablo)
valencia (bandar udara valencia)
gothenburg (bandar udara gothenburg-landvetter)
stockholm (bandar udara stockholm-bromma)
jenewa (bandar udara internasional geneva cointrin)
zrich (bandar udara internasional zrich)
athena (bandar udara internasional athens)
brussels airlines travels also in second life with b.places