leigh mengawali kariernya sebagai seorang remaja yang menjadi bintang tamu di beberapa acara televisi pada tahun 1970-an.
ia tampil perdana di dunia perfilman sebagai pemeran tokoh stacy hamilton dalam film fast times at ridgemont high (1982).
sejak saat itu ia terus memerankan tokoh-tokoh dewasa dan mendapat pujian atas penampilannya di film miami blues dan last exit to brooklyn tahun 1990.
tahun 1991, ia tampil di backdraft besutan ron howard, dan pada tahun 1992, ia membintangi film drama single white female.
tahun 1993, ia terlibat dalam film short cuts yang disutradarai robert altman, dan pada tahun 1994, ia membintangi the hudsucker proxy yang disutradarai coen bersaudara.
leigh mendapat nominasi golden globe atas pemeranan tokoh dorothy parker dalam mrs.
parker and the vicious circle (1994).
pada tahun 1995, ia membintangi film yang ditulis oleh ibunya sendiri, barbara turner, berjudul georgia.
tahun 2001, ia dan alan cumming menyutradarai film berjudul the anniversary party.
pada tahun 2002, leigh tampil di film drama kejahatan road to perdition.
tahun 2007, ia membintangi margot at the wedding yang disutradarai oleh mantan suaminya, noah baumbach.
ia memerankan tokoh berulang dalam seri televisi weeds sebagai jill price-gray. tahun 2015, ia mendapat pujian luas atas keterlibatannya sebagai pengisi suara lisa di anomalisa besutan charlie kaufman dan pemeran daisy domergue di the hateful eight yang disutradarai quentin tarantino.
atas perannya di the hateful eight, ia mendapat nominasi golden globe, critic's choice, bafta, dan academy award for best supporting actress.
di industri teater, leigh mendapat nominasi drama desk award atas penampilan off-broadway dalam lakon abigail's party karya mike leigh. leigh pertama kali terjun ke broadway tahun 1998 sebagai pengganti pemeran sally bowles di cabaret.
tidak masuk kredit
eyes of a stranger
the best little girl in the world
wrong is right
fast times at ridgemont high
flesh + blood
the men's club
heart of midnight
the big picture
last exit to brooklyn
boston society of film critics award for best supporting actress
boston society of film critics award for best supporting actressnew york film critics circle award for best supporting actress
single white female
hedra 'hedy' carlson/ellen besch
mtv movie award for best villainnominasichicago film critics association award for best actress
golden globe special award for best ensemble castvolpi cup for best acting ensemblenominasinational society of film critics award for best supporting actress (peringkat ke-3)nominasinew york film critics circle award for best supporting actress (peringkat ke-3)
the hudsucker proxy
mrs. parker and the vicious circle
chicago film critics association award for best actressnational society of film critics award for best actressnominasigolden globe award for best actress in a motion picture  dramanominasiindependent spirit award for best female leadnominasinew york film critics circle award for best actress (peringkat ke-2)
selena st. george
nominasisaturn award for best supporting actress
montreal world film festival award for best actressnew york film critics circle award for best actressnominasiindependent spirit award for best female leadnominasilos angeles film critics association award for best actressnominasinational society of film critics award for best actress (peringkat ke-2)
bastard out of carolina
a thousand acres
verona love screens film festival: best actress (bersama michelle pfeiffer dan jessica lange)
the king is alive
tokyo international film festival award for best actress
the man who wasn't there
the anniversary party
sekaligus penulis, produser, dan sutradaranominasiindependent spirit award for best first feature (bersama alan cumming)nominasiindependent spirit award for best first screenplay (bersama alan cumming)
road to perdition
karla faye tucker
in the cut
nominasifangoria chainsaw award for best supporting actress (peringkat ke-3)
genie award for best performance by an actress in a supporting rolenominasivancouver film critics circle for best actress in a canadian film
dr. beth lorenson
mary josephine morton
margot at the wedding
pescola comedy film festival award for best actressnominasichicago film critics association award for best supporting actressnominasidallasfort worth film critics association award for best supporting actressnominasigotham award for best ensemble castnominasiindependent spirit award for best supporting female
synecdoche, new york
gotham award for best ensemble castindependent spirit awards: robert altman award (bersama pemeran lainnya dan kru film)
sekaligus penulis dan produser
the spectacular now
kill your darlings
welcome to me
alliance of women film journalists award for best depiction of nudity, sexuality or seduction (bersama david thewlis, seri dengan carol)belum diputuskanannie award for voice acting in a feature productionbelum diputuskanindependent spirit award for best supporting femalenominasichicago film critics association award for best supporting actress
the hateful eight
daisy domergue a.k.a. "the prisoner"
florida film critics circle award for best supporting actress (runner up)hollywood film award for ensemble of the yearnational board of review award for best supporting actresssan diego film critics society award for best supporting actressbelum diputuskanaacta international award for best supporting actressbelum diputuskanacademy award for best supporting actressbelum diputuskanawards circuit community award for best supporting actressbelum diputuskanbafta award for best actress in a supporting rolebelum diputuskanhouston film critics society award for best supporting actressnominasichicago film critics association award for best supporting actressnominasicritics' choice movie award for best supporting actressnominasidetroit film critics society award for best supporting actressnominasigolden globe award for best supporting actress  motion picturenominasilas vegas film critics society award for best supporting actressnominasiphoenix critics circle award for best supporting actressnominasiphoenix film critics society award for best supporting actressnominasist.
louis gateway film critics association award for best supporting actressnominasiwashington d.c.
area film critics association award for best supporting actress
amityville: the awakening
lady bird johnson
episode: "and baby makes three"
episode: "the young runaways"
cbs schoolbreak special
episode: "i think i'm having a baby"
episode: "the pursuit"
diane, gadis di bar
episode: "samuels and the kid"
trapper john, m.d.
episode: "the one and only"
abc afterschool special
episode: "have you ever been ashamed of your parents?"
girls of the white orchid
the love letter
king of the hill
episode: "i remember mono"
tracey takes on...
adventures from the book of virtues
thanks of a grateful nation
film televisinominasisatellite award for best actress  miniseries or television film
superman: the animated series
episode: "absolute power"
todd mcfarlane's spawn
episode: "the life of reilly"
episode: "the two hundredth"
eunice eulmeyer (suara)
episode: "kevin loves weirdie"
8 april 1986  24 mei 1986
circle repertory theatre
9 desember 1989  14 januari 1990
stephen sondheim theatrestudio 54
4 agustus 1998  28 februari 1999
walter kerr theatre
13 september 2001  30 june 2002
theater of the new ear: anomalisa
14 september 2005  16 september 2005
1 december 2005  11 maret 2006nominasidrama desk award for outstanding actress in a playnominasilucille lortel award for outstanding lead actress
the house of blue leaves
walter kerr theatre
25 april 2011  25 juni 2011
"anima animus: jennifer jason leighs bisexual method in last exit to brooklyn" by ian murphy (article in alphaville journal)
jennifer jason leigh at internet off-broadway database
in-depth interview at museum of moving image in 1994
article in alphaville journal
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