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data/data_dev.conll

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+= PUNCT B-O
+Manual PROPN B-LF
+Ability PROPN I-LF
+Classification PROPN I-LF
+System PROPN I-LF
+; PUNCT B-O
+QUEST PROPN B-AC
+= PUNCT B-O
+Quest PROPN B-LF
+- ADJ I-LF
+Quality PROPN I-LF
+of ADP I-LF
+upper ADJ I-LF
+extremity NOUN I-LF
+skills NOUN I-LF
+test NOUN I-LF
+; PUNCT B-O
+Cont PROPN B-O
+= PUNCT B-O
+control NOUN B-O
+; PUNCT B-O
+M NOUN B-O
+= PUNCT B-O
+male NOUN B-O
+, PUNCT B-O
+F NOUN B-O
+= PUNCT B-O
+female ADJ B-O
+, PUNCT B-O
+V NOUN B-O
+= PUNCT B-O
+verbal ADJ B-O
+, PUNCT B-O
+nonV NOUN B-O
+= PUNCT B-O
+non ADJ B-O
+- ADJ B-O
+Verbal ADJ B-O
+, PUNCT B-O
+|Quad NOUN B-O
+= PUNCT B-O
+quadriplegia NOUN B-O
+, PUNCT B-O
+Di NOUN B-O
+= PUNCT B-O
+Diplegia NOUN B-O
+, PUNCT B-O
+Hemi NOUN B-O
+= PUNCT B-O
+hemiplegia NOUN B-O
+. PUNCT B-O
+
+Electro NOUN B-LF
+- PUNCT I-LF
+oculography NOUN I-LF
+( PUNCT B-O
+EOG PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+RetiPort32 PROPN B-O
+, PUNCT B-O
+Roland PROPN B-O
+Consult PROPN B-O
+, PUNCT B-O
+Wiesbaden PROPN B-O
+, PUNCT B-O
+Germany PROPN B-O
+) PUNCT B-O
+was AUX B-O
+performed VERB B-O
+in ADP B-O
+all DET B-O
+patients NOUN B-O
+according VERB B-O
+to ADP B-O
+the DET B-O
+guidelines NOUN B-O
+of ADP B-O
+the DET B-O
+International PROPN B-O
+Society PROPN B-O
+for ADP B-O
+Clinical PROPN B-O
+Electrophysiology PROPN B-O
+of ADP B-O
+Vision PROPN B-O
+( PUNCT B-O
+ISCEV).[12 PROPN B-O
+] PUNCT B-O
+Arden NOUN B-O
+ratios NOUN B-O
+below ADP B-O
+1.8 NUM B-O
+were AUX B-O
+rated VERB B-O
+as ADP B-O
+pathologic ADJ B-O
+. PUNCT B-O
+
+Soluble ADJ B-LF
+N NOUN I-LF
+- NOUN I-LF
+ethylmaleimide NOUN I-LF
+- NOUN I-LF
+sensitive ADJ I-LF
+factor NOUN I-LF
+attachment NOUN I-LF
+protein NOUN I-LF
+receptor NOUN I-LF
+( PUNCT B-O
+SNARE PROPN B-AC
+) PUNCT B-O
+proteins NOUN B-O
+, PUNCT B-O
+including VERB B-O
+target- NOUN B-O
+( PUNCT B-O
+t- NOUN B-O
+) PUNCT B-O
+membrane NOUN B-O
+SNAREs PROPN B-AC
+( PUNCT B-O
+Syntaxins PROPN B-LF
+[ X B-O
+Syn PROPN B-AC
+] PUNCT B-O
+) PUNCT B-O
+and CCONJ B-O
+synaptosomal NOUN B-O
+- NOUN B-O
+associated VERB B-O
+proteins NOUN B-O
+of ADP B-O
+25 NUM B-O
+kDa NOUN B-O
+( PUNCT B-O
+SNAP25 PROPN B-O
+) PUNCT B-O
+and CCONJ B-O
+vesicle NOUN B-LF
+- NOUN I-LF
+associated VERB I-LF
+membrane NOUN I-LF
+proteins NOUN I-LF
+( PUNCT B-O
+VAMPs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+are AUX B-O
+the DET B-O
+fundamental ADJ B-O
+components NOUN B-O
+of ADP B-O
+the DET B-O
+exocytotic ADJ B-O
+machinery NOUN B-O
+required VERB B-O
+for ADP B-O
+the DET B-O
+docking NOUN B-O
+and CCONJ B-O
+fusion NOUN B-O
+of ADP B-O
+secretory ADJ B-O
+granules NOUN B-O
+( PUNCT B-O
+SGs PROPN B-AC
+) PUNCT B-O
+with ADP B-O
+the DET B-O
+plasma NOUN B-LF
+membrane NOUN I-LF
+( PUNCT B-O
+PM PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+have AUX B-O
+been AUX B-O
+well ADV B-O
+studied VERB B-O
+in ADP B-O
+neurons NOUN B-O
+[ X B-O
+1 NUM B-O
+, PUNCT B-O
+2 NUM B-O
+] PUNCT B-O
+and CCONJ B-O
+neuroendocrine ADJ B-O
+cells NOUN B-O
+, PUNCT B-O
+particularly ADV B-O
+pancreatic ADJ B-O
+islet NOUN B-O
+β PUNCT B-O
+- NOUN B-O
+cells NOUN B-O
+[ X B-O
+3–5 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+t PROPN B-AC
+-SNAREs PROPN B-AC
+Syn-1A PROPN B-AC
+and CCONJ B-O
+SNAP25 PROPN B-O
+through ADP B-O
+their PRON B-O
+interactions NOUN B-O
+with ADP B-O
+PM PROPN B-AC
+- NOUN B-O
+bound VERB B-O
+voltage NOUN B-LF
+- NOUN I-LF
+gated VERB I-LF
+calcium NOUN I-LF
+channels NOUN I-LF
+( PUNCT B-O
+Cav PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+L NOUN B-O
+- NOUN B-O
+type NOUN B-O
+in ADP B-O
+β PUNCT B-O
+- NOUN B-O
+cells NOUN B-O
+and CCONJ B-O
+N NOUN B-O
+- NOUN B-O
+type NOUN B-O
+in ADP B-O
+neurons NOUN B-O
+, PUNCT B-O
+position VERB B-O
+the DET B-O
+predocked VERB B-O
+SGs PROPN B-AC
+to ADP B-O
+the DET B-O
+site NOUN B-O
+of ADP B-O
+maximum ADJ B-O
+Ca2 NOUN B-O
++ NOUN B-O
+influx NOUN B-O
+for ADP B-O
+efficient ADJ B-O
+exocytosis NOUN B-O
+[ X B-O
+6–12 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Large ADJ B-O
+whole ADJ B-LF
+genome NOUN I-LF
+sequencing NOUN I-LF
+( PUNCT B-O
+WGS PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+whole ADJ B-LF
+exome NOUN I-LF
+sequencing NOUN I-LF
+( PUNCT B-O
+WES PROPN B-AC
+) PUNCT B-O
+studies NOUN B-O
+in ADP B-O
+IBD PROPN B-AC
+are AUX B-O
+in ADP B-O
+progress NOUN B-O
+. PUNCT B-O
+
+Welsh PROPN B-O
+and CCONJ B-O
+coworkers NOUN B-O
+first ADV B-O
+reported VERB B-O
+that SCONJ B-O
+neurons NOUN B-O
+within ADP B-O
+the DET B-O
+suprachiasmatic ADJ B-LF
+nucleus NOUN I-LF
+( PUNCT B-O
+SCN PROPN B-AC
+; PUNCT B-O
+the DET B-O
+master NOUN B-O
+pacemaker NOUN B-O
+in ADP B-O
+the DET B-O
+hypothalamus NOUN B-O
+of ADP B-O
+mammals NOUN B-O
+) PUNCT B-O
+are AUX B-O
+surprisingly ADV B-O
+heterogeneous ADJ B-O
+in ADP B-O
+their PRON B-O
+intrinsic ADJ B-O
+periods NOUN B-O
+of ADP B-O
+circadian ADJ B-O
+firing NOUN B-O
+pattern NOUN B-O
+[ PUNCT B-O
+4 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+So ADV B-O
+far ADV B-O
+, PUNCT B-O
+reviews NOUN B-O
+investigating VERB B-O
+insulin NOUN B-O
+pump NOUN B-O
+therapy NOUN B-O
+showed VERB B-O
+mixed ADJ B-O
+results NOUN B-O
+regarding VERB B-O
+the DET B-O
+health NOUN B-LF
+- PUNCT I-LF
+related VERB I-LF
+quality NOUN I-LF
+of ADP I-LF
+life NOUN I-LF
+( PUNCT B-O
+HRQOL PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+paediatric ADJ B-O
+diabetes NOUN B-O
+patients.[13 NOUN B-O
+, PUNCT B-O
+16 NUM B-O
+, PUNCT B-O
+17 NUM B-O
+] PUNCT B-O
+According VERB B-O
+to ADP B-O
+recent ADJ B-O
+publications,[15 NOUN B-O
+, PUNCT B-O
+18–20 NUM B-O
+] PUNCT B-O
+there PRON B-O
+is VERB B-O
+still ADV B-O
+a DET B-O
+lack NOUN B-O
+of ADP B-O
+adequately ADV B-O
+powered VERB B-O
+studies NOUN B-O
+to ADP B-O
+underpin VERB B-O
+the DET B-O
+advantages NOUN B-O
+of ADP B-O
+CSII PROPN B-AC
+regarding VERB B-O
+QoL PROPN B-AC
+improvement NOUN B-O
+for ADP B-O
+children NOUN B-O
+diagnosed VERB B-O
+with ADP B-O
+DM PROPN B-AC
+and CCONJ B-O
+to ADP B-O
+potentially ADV B-O
+balance VERB B-O
+the DET B-O
+higher ADJ B-O
+treatment NOUN B-O
+cost NOUN B-O
+attached VERB B-O
+to ADP B-O
+it.[8 PRON B-O
+] PUNCT B-O
+Thus ADV B-O
+, PUNCT B-O
+insulin NOUN B-O
+pumps NOUN B-O
+are AUX B-O
+– PUNCT B-O
+forty NUM B-O
+years NOUN B-O
+after SCONJ B-O
+they PRON B-O
+were AUX B-O
+first ADJ B-O
+introduced VERB B-O
+to ADP B-O
+the DET B-O
+market NOUN B-O
+– PUNCT B-O
+still ADV B-O
+not PART B-O
+part NOUN B-O
+of ADP B-O
+first ADJ B-O
+- PUNCT B-O
+line NOUN B-O
+recommendations NOUN B-O
+in ADP B-O
+most ADJ B-O
+countries NOUN B-O
+around ADP B-O
+the DET B-O
+world NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+data NOUN B-O
+are AUX B-O
+reported VERB B-O
+as ADP B-O
+mean NOUN B-O
+± SYM B-O
+standard ADJ B-LF
+deviation NOUN I-LF
+( PUNCT B-O
+SD PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+n NOUN B-O
+≥ PUNCT B-O
+3 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+lack NOUN B-O
+of ADP B-O
+dystrophin NOUN B-O
+in ADP B-O
+Duchenne PROPN B-LF
+muscular ADJ I-LF
+dystrophy NOUN I-LF
+( PUNCT B-O
+DMD PROPN B-AC
+) PUNCT B-O
+compromises VERB B-O
+the DET B-O
+integrity NOUN B-O
+and CCONJ B-O
+function NOUN B-O
+of ADP B-O
+muscle NOUN B-O
+fibers NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+respondents NOUN B-O
+consisted VERB B-O
+of ADP B-O
+20 NUM B-O
+to PART B-O
+42 NUM B-O
+years NOUN B-O
+of ADP B-O
+age NOUN B-O
+with ADP B-O
+a DET B-O
+mean ADJ B-O
+age NOUN B-O
+and CCONJ B-O
+standard ADJ B-LF
+deviation NOUN I-LF
+( PUNCT B-O
+SD PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+25.95±3.81 NUM B-O
+. PUNCT B-O
+
+Here ADV B-O
+we PRON B-O
+provide VERB B-O
+a DET B-O
+direct ADJ B-O
+demonstration NOUN B-O
+, PUNCT B-O
+based VERB B-O
+on ADP B-O
+our PRON B-O
+analysis NOUN B-O
+of ADP B-O
+rad-50 NOUN B-O
+mutants NOUN B-O
+, PUNCT B-O
+that SCONJ B-O
+the DET B-O
+meiotic ADJ B-O
+program NOUN B-O
+in ADP B-O
+Caenorhabditis PROPN B-O
+elegans NOUN B-O
+involves VERB B-O
+both DET B-O
+acquisition NOUN B-O
+and CCONJ B-O
+loss NOUN B-O
+of ADP B-O
+a DET B-O
+specialized ADJ B-O
+mode NOUN B-O
+of ADP B-O
+double ADJ B-LF
+- PUNCT I-LF
+strand NOUN I-LF
+break NOUN I-LF
+repair NOUN I-LF
+( PUNCT B-O
+DSBR PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+premeiotic ADJ B-O
+germ NOUN B-O
+cells NOUN B-O
+, PUNCT B-O
+RAD-50 PROPN B-O
+is AUX B-O
+not PART B-O
+required VERB B-O
+to PART B-O
+load VERB B-O
+strand NOUN B-O
+- PUNCT B-O
+exchange NOUN B-O
+protein NOUN B-O
+RAD-51 PROPN B-O
+at ADP B-O
+sites NOUN B-O
+of ADP B-O
+spontaneous ADJ B-O
+or CCONJ B-O
+ionizing ADJ B-LF
+radiation NOUN I-LF
+( PUNCT B-O
+IR)-inducedDSBs PROPN B-AC
+. PUNCT B-O
+
+A DET B-O
+specialized ADJ B-O
+meiotic ADJ B-O
+DSBR PROPN B-AC
+mode NOUN B-O
+is AUX B-O
+engaged VERB B-O
+at ADP B-O
+the DET B-O
+onset NOUN B-O
+of ADP B-O
+meiotic ADJ B-O
+prophase NOUN B-O
+, PUNCT B-O
+coincident ADJ B-O
+with ADP B-O
+assembly NOUN B-O
+of ADP B-O
+meiotic ADJ B-O
+chromosome NOUN B-O
+axis NOUN B-O
+structures NOUN B-O
+. PUNCT B-O
+
+Figure NOUN B-O
+3 NUM B-O
+illustrates VERB B-O
+the DET B-O
+differences NOUN B-O
+in ADP B-O
+the DET B-O
+estimates NOUN B-O
+of ADP B-O
+the DET B-O
+annual ADJ B-LF
+rate NOUN I-LF
+of ADP I-LF
+reduction NOUN I-LF
+( PUNCT B-O
+ARR PROPN B-AC
+) PUNCT B-O
+from ADP B-O
+1990 NUM B-O
+to ADP B-O
+2010 NUM B-O
+for ADP B-O
+all DET B-O
+countries NOUN B-O
+. PUNCT B-O
+
+In ADP B-O
+order NOUN B-O
+to PART B-O
+further ADV B-O
+confirm VERB B-O
+that SCONJ B-O
+the DET B-O
+interaction NOUN B-O
+of ADP B-O
+the DET B-O
+η8 NUM B-O
+helix NOUN B-O
+with ADP B-O
+Rps14 NOUN B-O
+is AUX B-O
+not PART B-O
+an DET B-O
+artifact NOUN B-O
+of ADP B-O
+crystal NOUN B-O
+packing NOUN B-O
+, PUNCT B-O
+we PRON B-O
+have AUX B-O
+conducted VERB B-O
+structural ADJ B-O
+studies NOUN B-O
+in ADP B-O
+solution NOUN B-O
+by ADP B-O
+small ADJ B-LF
+angle NOUN I-LF
+X NOUN I-LF
+- NOUN I-LF
+ray NOUN I-LF
+scattering NOUN I-LF
+( PUNCT B-O
+SAXS PROPN B-AC
+) PUNCT B-O
+on ADP B-O
+the DET B-O
+aFap7 NOUN B-O
+– PUNCT B-O
+aRps14 NOUN B-O
+complex NOUN B-O
+. PUNCT B-O
+
+To PART B-O
+identify VERB B-O
+the DET B-O
+BDNF PROPN B-AC
+- PUNCT B-O
+responsive ADJ B-O
+proliferating VERB B-O
+cells NOUN B-O
+, PUNCT B-O
+we PRON B-O
+performed VERB B-O
+co NOUN B-O
+- PUNCT B-O
+staining NOUN B-O
+with ADP B-O
+astrocyte NOUN B-O
+marker NOUN B-O
+GFAP PROPN B-O
+and CCONJ B-O
+found VERB B-O
+that SCONJ B-O
+the DET B-O
+cells NOUN B-O
+positive ADJ B-O
+for ADP B-O
+Ki67 PROPN B-AC
+( PUNCT B-O
+antigen NOUN B-LF
+identified VERB I-LF
+by ADP I-LF
+monoclonal ADJ I-LF
+antibody NOUN I-LF
+Ki-67 PROPN I-LF
+, PUNCT B-O
+a DET B-O
+marker NOUN B-O
+for ADP B-O
+proliferating VERB B-O
+cells NOUN B-O
+) PUNCT B-O
+are AUX B-O
+GFAP PROPN B-O
+negative ADJ B-O
+, PUNCT B-O
+suggesting VERB B-O
+that SCONJ B-O
+BDNF PROPN B-AC
+- PUNCT B-O
+responsive ADJ B-O
+proliferating VERB B-O
+cells NOUN B-O
+are AUX B-O
+not PART B-O
+astrocytes NOUN B-O
+( PUNCT B-O
+S7 NUM B-O
+Fig NOUN B-O
+, PUNCT B-O
+S10 NUM B-O
+Fig NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+particular ADJ B-O
+, PUNCT B-O
+experiencing VERB B-O
+moderate ADJ B-O
+/ SYM B-O
+high ADJ B-O
+levels NOUN B-O
+of ADP B-O
+perceived VERB B-O
+stress NOUN B-O
+was AUX B-O
+associated VERB B-O
+with ADP B-O
+a DET B-O
+1.61 ADJ B-O
+- ADJ B-O
+fold ADJ B-O
+increase NOUN B-O
+in ADP B-O
+the DET B-O
+odds NOUN B-LF
+ratio NOUN I-LF
+( PUNCT B-O
+OR PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+having AUX B-O
+ever ADV B-O
+smoked VERB B-O
+( PUNCT B-O
+95%CI PROPN B-AC
+1.42 NUM B-O
+, PUNCT B-O
+1.83 NUM B-O
+; PUNCT B-O
+P<0.001 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+a DET B-O
+1.67 ADJ B-O
+- ADJ B-O
+fold ADJ B-O
+increase NOUN B-O
+in ADP B-O
+having AUX B-O
+been AUX B-O
+diagnosed VERB B-O
+or CCONJ B-O
+treated VERB B-O
+for ADP B-O
+hypertension NOUN B-O
+( PUNCT B-O
+95%CI PROPN B-AC
+1.46 NUM B-O
+, PUNCT B-O
+1.90 NUM B-O
+; PUNCT B-O
+P<0.001 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Kaposi PROPN B-LF
+'s PART I-LF
+sarcoma NOUN I-LF
+- PUNCT I-LF
+associated VERB I-LF
+herpesvirus NOUN I-LF
+( PUNCT B-O
+KSHV PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+the DET B-O
+most ADV B-O
+recently ADV B-O
+discovered VERB B-O
+human ADJ B-O
+herpesvirus NOUN B-O
+and CCONJ B-O
+the DET B-O
+etiologic ADJ B-O
+agent NOUN B-O
+of ADP B-O
+several ADJ B-O
+neoplasms NOUN B-O
+, PUNCT B-O
+the DET B-O
+most ADV B-O
+prominent ADJ B-O
+of ADP B-O
+which PRON B-O
+is AUX B-O
+Kaposi PROPN B-O
+'s PART B-O
+sarcoma NOUN B-O
+( PUNCT B-O
+KS PROPN B-O
+) PUNCT B-O
+[ PUNCT B-O
+1 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Other ADJ B-O
+methods NOUN B-O
+of ADP B-O
+assaying VERB B-O
+recombination NOUN B-O
+in ADP B-O
+A. NOUN B-O
+thaliana PROPN B-O
+have AUX B-O
+been AUX B-O
+developed VERB B-O
+, PUNCT B-O
+and CCONJ B-O
+one NUM B-O
+in ADP B-O
+particular ADJ B-O
+involving VERB B-O
+a DET B-O
+tandem NOUN B-O
+disrupted VERB B-O
+beta NOUN B-LF
+- PUNCT I-LF
+D NOUN I-LF
+- PUNCT I-LF
+glucuronidase NOUN I-LF
+( PUNCT B-O
+GUS PROPN B-AC
+) PUNCT B-O
+gene NOUN B-O
+[ X B-O
+43 X B-O
+] PUNCT B-O
+was AUX B-O
+recently ADV B-O
+applied VERB B-O
+to PART B-O
+study VERB B-O
+recombination NOUN B-O
+in ADP B-O
+Atmus81 PROPN B-O
+mutants NOUN B-O
+[ X B-O
+27 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Although SCONJ B-O
+one PRON B-O
+should AUX B-O
+be AUX B-O
+careful ADJ B-O
+to ADP B-O
+relate VERB B-O
+absolute ADJ B-O
+concentrations NOUN B-O
+from ADP B-O
+an DET B-O
+in ADP B-O
+vitro X B-O
+assay NOUN B-O
+to ADP B-O
+actual ADJ B-O
+drug NOUN B-O
+concentrations NOUN B-O
+administered VERB B-O
+to ADP B-O
+patients NOUN B-O
+and CCONJ B-O
+clinical ADJ B-O
+antibiotic ADJ B-O
+breakpoints NOUN B-O
+[ PUNCT B-O
+61 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+we PRON B-O
+found VERB B-O
+that SCONJ B-O
+the DET B-O
+dose NOUN B-O
+- PUNCT B-O
+responses NOUN B-O
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+our PRON B-O
+PAO1 PROPN B-O
+WT PROPN B-AC
+strain NOUN B-O
+( PUNCT B-O
+and CCONJ B-O
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+inhibitory ADJ I-LF
+concentrations NOUN I-LF
+[ PUNCT B-O
+MICs PROPN B-AC
+] PUNCT B-O
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+Fig NUM B-O
+1 NUM B-O
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+to ADP B-O
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+MIC50 NUM B-O
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+7,452 NUM B-O
+clinical ADJ B-O
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+62 NUM B-O
+] PUNCT B-O
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+
+A DET B-O
+15 NUM B-O
+- PUNCT B-O
+s NOUN B-O
+rest NOUN B-O
+period NOUN B-O
+preceded VERB B-O
+and CCONJ B-O
+followed VERB B-O
+each DET B-O
+block NOUN B-O
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+( PUNCT B-O
+C X B-O
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+image NOUN B-O
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+a DET B-O
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+subject NOUN B-O
+) PUNCT B-O
+were AUX B-O
+acquired VERB B-O
+and CCONJ B-O
+covered VERB B-O
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+brain NOUN B-O
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+cord NOUN B-O
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+the DET B-O
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+( PUNCT B-O
+T1 PROPN B-AC
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+segment NOUN B-O
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+they PRON B-O
+were AUX B-O
+placed VERB B-O
+at ADP B-O
+an DET B-O
+angle NOUN B-O
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+was AUX B-O
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+the DET B-O
+C4 NOUN B-O
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+segment NOUN B-O
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+( PUNCT B-O
+D NOUN B-O
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+Performance NOUN B-O
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+( PUNCT B-O
+i.e. X B-O
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+block NOUN B-O
+duration NOUN B-O
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+across ADP B-O
+all DET B-O
+subjects NOUN B-O
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+that SCONJ B-O
+the DET B-O
+learning NOUN B-O
+curves NOUN B-O
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+the DET B-O
+CS PROPN B-AC
+( PUNCT B-O
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+( PUNCT B-O
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+) PUNCT B-O
+conditions NOUN B-O
+. PUNCT B-O
+
+We PRON B-O
+found VERB B-O
+that SCONJ B-O
+SOCS1 PROPN B-O
+- PUNCT B-O
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+DCs PROPN B-AC
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+induced VERB B-O
+enhanced ADJ B-O
+envelope NOUN B-LF
+HIV-1 PROPN B-AC
+( PUNCT B-O
+Env)-specific PROPN B-AC
+CD8 NOUN B-O
++ NOUN B-O
+cytotoxic ADJ B-O
+T NOUN B-O
+lymphocytes NOUN B-O
+and CCONJ B-O
+CD4 NOUN B-O
++ NOUN B-O
+T NOUN B-O
+helper NOUN B-O
+cells NOUN B-O
+, PUNCT B-O
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+well ADV B-O
+as ADP B-O
+antibody NOUN B-O
+responses NOUN B-O
+, PUNCT B-O
+in ADP B-O
+mice NOUN B-O
+. PUNCT B-O
+
+This PRON B-O
+is AUX B-O
+potentially ADV B-O
+attributed VERB B-O
+to ADP B-O
+decreased VERB B-O
+T PROPN B-LF
+cell NOUN I-LF
+receptor NOUN I-LF
+( PUNCT B-O
+TCR PROPN B-AC
+) PUNCT B-O
+signaling NOUN B-O
+strength NOUN B-O
+due ADP B-O
+to ADP B-O
+inefficiency NOUN B-O
+in ADP B-O
+promiscuous ADJ B-O
+expression NOUN B-O
+of ADP B-O
+self NOUN B-O
+- PUNCT B-O
+antigens NOUN B-O
+or CCONJ B-O
+presenting VERB B-O
+a DET B-O
+neo NOUN B-O
+- PUNCT B-O
+self NOUN B-O
+- PUNCT B-O
+antigen NOUN B-O
+by ADP B-O
+medullary ADJ B-O
+TECs PROPN B-AC
+, PUNCT B-O
+displaying VERB B-O
+decreased VERB B-O
+negative ADJ B-O
+selection NOUN B-O
+- PUNCT B-O
+related VERB B-O
+marker NOUN B-O
+genes NOUN B-O
+( PUNCT B-O
+Nur77 PROPN B-O
+and CCONJ B-O
+CD5high PROPN B-O
+) PUNCT B-O
+in ADP B-O
+CD4 PROPN B-O
+single ADJ B-LF
+positive ADJ I-LF
+( PUNCT B-O
+SP PROPN B-AC
+) PUNCT B-O
+thymocytes NOUN B-O
+. PUNCT B-O
+
+Members NOUN B-O
+of ADP B-O
+the DET B-O
+plant NOUN B-O
+Heme PROPN B-LF
+Activator PROPN I-LF
+Protein PROPN I-LF
+( PUNCT B-O
+HAP PROPN B-AC
+) PUNCT B-O
+or CCONJ B-O
+NUCLEAR PROPN B-O
+FACTOR PROPN B-O
+Y PROPN B-O
+( PUNCT B-O
+NF PROPN B-O
+- PUNCT B-O
+Y PROPN B-O
+) PUNCT B-O
+are AUX B-O
+trimeric ADJ B-O
+transcription NOUN B-O
+factor NOUN B-O
+complexes NOUN B-O
+composed VERB B-O
+of ADP B-O
+the DET B-O
+NF PROPN B-O
+- PUNCT B-O
+YA PROPN B-O
+, PUNCT B-O
+NF PROPN B-O
+- PUNCT B-O
+YB PROPN B-O
+and CCONJ B-O
+NF PROPN B-O
+- PUNCT B-O
+YC PROPN B-O
+subfamilies NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+wing NOUN B-O
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+is AUX B-O
+a DET B-O
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+structure NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+its PRON B-O
+formation NOUN B-O
+requires VERB B-O
+the DET B-O
+proper ADJ B-O
+expression NOUN B-O
+of ADP B-O
+cuticle NOUN B-O
+- PUNCT B-O
+related VERB B-O
+genes NOUN B-O
+, PUNCT B-O
+such ADJ B-O
+as ADP B-O
+enzymes NOUN B-O
+involved VERB B-O
+in ADP B-O
+cuticle NOUN B-O
+deposition NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+zona NOUN B-LF
+pellucida NOUN I-LF
+( PUNCT B-O
+ZP PROPN B-AC
+) PUNCT B-O
+domain NOUN B-O
+proteins NOUN B-O
+, PUNCT B-O
+which PRON B-O
+link VERB B-O
+the DET B-O
+apical ADJ B-O
+surface NOUN B-O
+of ADP B-O
+wing NOUN B-O
+cells NOUN B-O
+to ADP B-O
+the DET B-O
+overlying VERB B-O
+cuticle NOUN B-O
+[ PUNCT B-O
+37 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+After ADP B-O
+confirming VERB B-O
+this DET B-O
+result NOUN B-O
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+quantitative ADJ B-LF
+real ADJ I-LF
+- PUNCT I-LF
+time NOUN I-LF
+reverse ADJ I-LF
+transcription NOUN I-LF
+polymerase NOUN I-LF
+chain NOUN I-LF
+reaction NOUN I-LF
+( PUNCT B-O
+qRT-PCR PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+we PRON B-O
+extended VERB B-O
+the DET B-O
+qRT PROPN B-AC
+analysis NOUN B-O
+to ADP B-O
+other ADJ B-O
+kidney NOUN B-O
+diseases NOUN B-O
+and CCONJ B-O
+found VERB B-O
+that SCONJ B-O
+-PCRIFI27 PROPN B-AC
+mRNA NOUN B-O
+levels NOUN B-O
+were AUX B-O
+reduced VERB B-O
+in ADP B-O
+PBMCs PROPN B-AC
+of ADP B-O
+many ADJ B-O
+patients NOUN B-O
+. PUNCT B-O
+
+a X B-O
+) PUNCT B-O
+correlation NOUN B-LF
+coefficient NOUN B-O
+r PROPN B-AC
+, PUNCT B-O
+which PRON B-O
+ranges VERB B-O
+between ADP B-O
+0 NUM B-O
+( PUNCT B-O
+no DET B-O
+relationship NOUN B-O
+) PUNCT B-O
+to ADP B-O
+1 NUM B-O
+( PUNCT B-O
+perfect ADJ B-O
+relationship NOUN B-O
+) PUNCT B-O
+or CCONJ B-O
+-1 NUM B-O
+( PUNCT B-O
+perfect ADJ B-O
+negative ADJ B-O
+relationship NOUN B-O
+) PUNCT B-O
+respectively ADV B-O
+. PUNCT B-O
+
+Therefore ADV B-O
+, PUNCT B-O
+the DET B-O
+aim NOUN B-O
+of ADP B-O
+this DET B-O
+study NOUN B-O
+was AUX B-O
+to ADP B-O
+evaluate VERB B-O
+the DET B-O
+importance NOUN B-O
+of ADP B-O
+both CCONJ B-O
+systemic ADJ B-O
+oxygen NOUN B-O
+delivery NOUN B-O
+factors NOUN B-O
+and CCONJ B-O
+peripheral ADJ B-O
+factors NOUN B-O
+for ADP B-O
+aerobic ADJ B-O
+ExCap PROPN B-AC
+in ADP B-O
+mild ADJ B-O
+- ADJ B-O
+to ADP B-O
+- ADJ B-O
+severe ADJ B-O
+non ADJ B-O
+- ADJ B-O
+dialysis ADJ B-O
+CKD PROPN B-AC
+. PUNCT B-O
+
+Handgrip NOUN B-O
+strength NOUN B-O
+, PUNCT B-O
+lean ADJ B-LF
+body NOUN I-LF
+mass NOUN I-LF
+( PUNCT B-O
+LBM PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+vascular ADJ B-O
+stiffness NOUN B-O
+represent VERB B-O
+peripheral ADJ B-O
+factors NOUN B-O
+in ADP B-O
+the DET B-O
+present ADJ B-O
+study NOUN B-O
+. PUNCT B-O
+
+To PART B-O
+further ADV B-O
+investigate VERB B-O
+whether SCONJ B-O
+BMAL1 PROPN B-O
+- PUNCT B-O
+K537 PROPN B-O
+acetylation NOUN B-O
+up ADV B-O
+- PUNCT B-O
+regulates VERB B-O
+BMAL1 PROPN B-O
+– PUNCT B-O
+CK2β NOUN B-O
+binding VERB B-O
+and CCONJ B-O
+subsequently ADV B-O
+represses VERB B-O
+BMAL1 PROPN B-O
+- PUNCT B-O
+S90 NOUN B-O
+phosphorylation NOUN B-O
+, PUNCT B-O
+we PRON B-O
+utilized VERB B-O
+a DET B-O
+mouse NOUN B-O
+fibroblast NOUN B-O
+cell NOUN B-O
+line NOUN B-O
+deficient ADJ B-O
+in ADP B-O
+silent ADJ B-O
+information NOUN B-O
+regulator NOUN B-O
+1 NUM B-O
+( PUNCT B-O
+SIRT1 PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+a DET B-O
+member NOUN B-O
+of ADP B-O
+the DET B-O
+sirtuin NOUN B-O
+family NOUN B-O
+of ADP B-O
+NAD+-dependent PROPN B-O
+histone NOUN B-LF
+deacetylases NOUN I-LF
+( PUNCT B-O
+HDACs PROPN B-AC
+) PUNCT B-O
+that PRON B-O
+also ADV B-O
+targets VERB B-O
+acetyl NOUN B-O
+BMAL1 PROPN B-O
+- PUNCT B-O
+K537 PROPN B-O
+[ PUNCT B-O
+30 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+EP PROPN B-AC
+: PUNCT B-O
+Group NOUN B-O
+: PUNCT B-O
+extra ADJ B-LF
+- ADJ I-LF
+perigastric ADJ I-LF
+lymph NOUN B-O
+node NOUN B-O
+group NOUN B-O
+A DET B-O
+recent ADJ B-O
+result NOUN B-O
+from ADP B-O
+S. PROPN B-O
+pombe PROPN B-O
+suggests VERB B-O
+that SCONJ B-O
+in ADP B-O
+this DET B-O
+organism NOUN B-O
+, PUNCT B-O
+in ADP B-O
+which PRON B-O
+all DET B-O
+COs PROPN B-AC
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+mediated VERB B-O
+by ADP B-O
+Mus81 PROPN B-O
+- PUNCT B-O
+Eme1 PROPN B-O
+, PUNCT B-O
+the DET B-O
+predominant ADJ B-O
+meiotic ADJ B-O
+recombination NOUN B-O
+intermediate NOUN B-O
+is AUX B-O
+a DET B-O
+single ADJ B-LF
+Holliday PROPN I-LF
+junction NOUN I-LF
+( PUNCT B-O
+sHJ PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+26 NUM B-O
+] PUNCT B-O
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+Ab PROPN B-AC
+, PUNCT B-O
+antibody NOUN B-LF
+; PUNCT B-O
+EC50 PROPN B-AC
+, PUNCT B-O
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+- PUNCT I-LF
+maximal ADJ I-LF
+effective ADJ I-LF
+concentration NOUN I-LF
+; PUNCT B-O
+IL-6R PROPN B-AC
+, PUNCT B-O
+interleukin-6 NOUN B-LF
+receptor NOUN I-LF
+; PUNCT B-O
+MMP PROPN B-AC
+, PUNCT B-O
+matrix NOUN B-LF
+metalloproteinase NOUN I-LF
+. PUNCT B-O
+
+QALY PROPN B-AC
+, PUNCT B-O
+quality NOUN B-LF
+- PUNCT I-LF
+adjusted VERB I-LF
+life NOUN I-LF
+year NOUN I-LF
+; PUNCT B-O
+USD PROPN B-O
+, PUNCT B-O
+US PROPN B-O
+dollars NOUN B-O
+. PUNCT B-O
+
+We PRON B-O
+adapted VERB B-O
+the DET B-O
+Preferred ADJ B-LF
+Reporting PROPN I-LF
+Items PROPN I-LF
+for ADP I-LF
+Systematic PROPN I-LF
+Reviews PROPN I-LF
+and CCONJ I-LF
+Meta PROPN I-LF
+- PUNCT I-LF
+Analyses PROPN I-LF
+( PUNCT B-O
+PRISMA PROPN B-AC
+) PUNCT B-O
+statement NOUN B-O
+for ADP B-O
+scoping NOUN B-O
+reviews NOUN B-O
+to PART B-O
+report VERB B-O
+our PRON B-O
+systematic ADJ B-O
+review NOUN B-O
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+observational ADJ B-O
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+interventional ADJ B-O
+studies NOUN B-O
+[ X B-O
+19 X B-O
+] X B-O
+( PUNCT B-O
+S1 PROPN B-O
+Table NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Plates NOUN B-O
+were AUX B-O
+developed VERB B-O
+, PUNCT B-O
+and CCONJ B-O
+the DET B-O
+optical ADJ B-LF
+density NOUN I-LF
+( PUNCT B-O
+OD PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+read VERB B-O
+using VERB B-O
+a DET B-O
+spectrophotometer NOUN B-O
+( PUNCT B-O
+microplate NOUN B-O
+reader NOUN B-O
+; PUNCT B-O
+Molecular PROPN B-O
+Devices PROPN B-O
+, PUNCT B-O
+Sunnyvale PROPN B-O
+, PUNCT B-O
+CA PROPN B-O
+, PUNCT B-O
+US PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Raw ADJ B-O
+OD PROPN B-AC
+for ADP B-O
+each DET B-O
+specimen NOUN B-O
+was AUX B-O
+normalized VERB B-O
+using VERB B-O
+the DET B-O
+calibrator NOUN B-O
+OD PROPN B-AC
+on ADP B-O
+each DET B-O
+plate NOUN B-O
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+a DET B-O
+ratio NOUN B-O
+, PUNCT B-O
+such ADJ B-O
+that SCONJ B-O
+normalized VERB B-O
+OD PROPN B-AC
+= SYM B-O
+OD PROPN B-AC
+of ADP B-O
+specimen NOUN B-O
+/ SYM B-O
+median NOUN B-O
+OD PROPN B-AC
+of ADP B-O
+calibrator NOUN B-O
+. PUNCT B-O
+
+Hemophagocytic ADJ B-LF
+lymphohistiocytosis NOUN I-LF
+( PUNCT B-O
+HLH PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+also ADV B-O
+known VERB B-O
+as ADP B-O
+hemophagocytic ADJ B-O
+syndrome NOUN B-O
+, PUNCT B-O
+is AUX B-O
+a DET B-O
+rare ADJ B-O
+, PUNCT B-O
+life NOUN B-O
+threatening VERB B-O
+hyperinflammatory ADJ B-O
+syndrome NOUN B-O
+characterized VERB B-O
+by ADP B-O
+excessive ADJ B-O
+activation NOUN B-O
+of ADP B-O
+histiocytes NOUN B-O
+and CCONJ B-O
+T NOUN B-O
+lymphocytes NOUN B-O
+leading VERB B-O
+to ADP B-O
+highly ADV B-O
+active ADJ B-O
+but CCONJ B-O
+ineffective ADJ B-O
+immune ADJ B-O
+response NOUN B-O
+[ PUNCT B-O
+1 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Our PRON B-O
+assumption NOUN B-O
+of ADP B-O
+constant ADJ B-O
+As PROPN B-AC
+levels NOUN B-O
+throughout ADP B-O
+the DET B-O
+study NOUN B-O
+period NOUN B-O
+is AUX B-O
+supported VERB B-O
+by ADP B-O
+geological ADJ B-O
+data NOUN B-O
+which PRON B-O
+document VERB B-O
+stable ADJ B-O
+arsenic NOUN B-LF
+contamination NOUN B-O
+of ADP B-O
+the DET B-O
+hydrothermal ADJ B-O
+system NOUN B-O
+that DET B-O
+has AUX B-O
+supplied VERB B-O
+drinking NOUN B-O
+water NOUN B-O
+in ADP B-O
+the DET B-O
+study NOUN B-O
+area NOUN B-O
+since SCONJ B-O
+the DET B-O
+‘ PUNCT B-O
+70s NOUN B-O
+[ PUNCT B-O
+14 NUM B-O
+, PUNCT B-O
+15 NUM B-O
+, PUNCT B-O
+17–19 NUM B-O
+] PUNCT B-O
+and CCONJ B-O
+to ADP B-O
+the DET B-O
+lack NOUN B-O
+of ADP B-O
+any DET B-O
+remediation NOUN B-O
+treatment NOUN B-O
+in ADP B-O
+that DET B-O
+time NOUN B-O
+due ADP B-O
+to ADP B-O
+the DET B-O
+long ADJ B-O
+period NOUN B-O
+of ADP B-O
+derogations NOUN B-O
+[ PUNCT B-O
+68 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+NCD PROPN B-AC
+, PUNCT B-O
+noncommunicable ADJ B-LF
+disease NOUN I-LF
+; PUNCT B-O
+OLS PROPN B-AC
+, PUNCT B-O
+ordinary ADJ B-LF
+least ADJ I-LF
+squares NOUN I-LF
+. PUNCT B-O
+
+To PART B-O
+further ADV B-O
+identify VERB B-O
+the DET B-O
+molecular ADJ B-O
+mechanism NOUN B-O
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+sIBM PROPN B-AC
+, PUNCT B-O
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+whole ADJ B-O
+mitochondrial ADJ B-LF
+DNA NOUN I-LF
+( PUNCT B-O
+mtDNA PROPN B-AC
+) PUNCT B-O
+from ADP B-O
+myoblasts NOUN B-O
+from ADP B-O
+normal ADJ B-O
+controls NOUN B-O
+and CCONJ B-O
+3 NUM B-O
+sIBM PROPN B-AC
+patients NOUN B-O
+. PUNCT B-O
+
+To PART B-O
+test VERB B-O
+whether SCONJ B-O
+F NOUN B-O
+- PUNCT B-O
+actin NOUN B-O
+polymerization NOUN B-O
+dynamics NOUN B-O
+are AUX B-O
+required VERB B-O
+for ADP B-O
+proper ADJ B-O
+VP26 PROPN B-O
+organization NOUN B-O
+, PUNCT B-O
+we PRON B-O
+treated VERB B-O
+cells NOUN B-O
+with ADP B-O
+the DET B-O
+actin NOUN B-O
+filament NOUN B-O
+- PUNCT B-O
+stabilizing VERB B-O
+drug NOUN B-O
+jasplakinolide PROPN B-LF
+( PUNCT B-O
+jasp PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+There PRON B-O
+were VERB B-O
+no DET B-O
+reported VERB B-O
+differences NOUN B-O
+between ADP B-O
+deaths NOUN B-O
+in ADP B-O
+males NOUN B-O
+and CCONJ B-O
+females NOUN B-O
+in ADP B-O
+Boukoki PROPN B-O
+( PUNCT B-O
+male NOUN B-LF
+- PUNCT I-LF
+to ADP I-LF
+- PUNCT I-LF
+female NOUN I-LF
+ratio NOUN I-LF
+[ PUNCT B-O
+M:Fratio PROPN B-AC
+] PUNCT B-O
+1.3:1 NUM B-O
+[ PUNCT B-O
+17:13 NUM B-O
+, PUNCT B-O
+p NOUN B-O
+= SYM B-O
+0.79 NUM B-O
+] PUNCT B-O
+) PUNCT B-O
+or CCONJ B-O
+in ADP B-O
+Moursal PROPN B-O
+( PUNCT B-O
+M PROPN B-AC
+1.5:1 NUM B-O
+[ PUNCT B-O
+12:8 NUM B-O
+, PUNCT B-O
+p NOUN B-O
+= SYM B-O
+0.75 NUM B-O
+] PUNCT B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Rev NOUN B-O
+# NOUN B-O
+3 NUM B-O
+: PUNCT B-O
+“ PUNCT B-O
+Is AUX B-O
+GAL PROPN B-AC
+gene NOUN B-O
+optimization NOUN B-O
+not PART B-O
+correlated VERB B-O
+with ADP B-O
+growth NOUN B-O
+under ADP B-O
+other ADJ B-O
+( PUNCT B-O
+non ADJ B-O
+- ADJ B-O
+galactose ADJ B-LF
+) PUNCT B-O
+growth NOUN B-O
+conditions NOUN B-O
+? PUNCT B-O
+” PUNCT B-O
+As SCONJ B-O
+the DET B-O
+world NOUN B-O
+edges VERB B-O
+closer ADV B-O
+to ADP B-O
+global ADJ B-O
+polio NOUN B-O
+eradication NOUN B-O
+and CCONJ B-O
+continues VERB B-O
+the DET B-O
+strategic ADJ B-O
+withdrawal NOUN B-O
+of ADP B-O
+the DET B-O
+Oral PROPN B-LF
+Polio PROPN I-LF
+Vaccine PROPN I-LF
+( PUNCT B-O
+OPV PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+the DET B-O
+regular ADJ B-O
+identification NOUN B-O
+of ADP B-O
+, PUNCT B-O
+and CCONJ B-O
+rapid ADJ B-O
+response NOUN B-O
+to ADP B-O
+, PUNCT B-O
+these DET B-O
+silent ADJ B-O
+chains NOUN B-O
+of ADP B-O
+transmission NOUN B-O
+is AUX B-O
+of ADP B-O
+the DET B-O
+utmost ADJ B-O
+importance NOUN B-O
+. PUNCT B-O
+
+ABA PROPN B-AC
+, PUNCT B-O
+abscisic NOUN B-LF
+acid NOUN I-LF
+; PUNCT B-O
+BR PROPN B-AC
+, PUNCT B-O
+brassinosteroid NOUN B-LF
+; PUNCT B-O
+GA3 PROPN B-AC
+, PUNCT B-O
+gibberellic NOUN B-LF
+acid3 NOUN I-LF
+; PUNCT B-O
+ZR PROPN B-AC
+, PUNCT B-O
+zeatin NOUN B-LF
+riboside NOUN I-LF
+Green ADJ B-LF
+tea NOUN I-LF
+( PUNCT B-O
+GT PROPN B-AC
+) PUNCT B-O
+catechins NOUN B-O
+have VERB B-O
+been AUX B-O
+shown VERB B-O
+to PART B-O
+have VERB B-O
+anti ADJ B-O
+- ADJ B-O
+obesity ADJ B-O
+effects NOUN B-O
+in ADP B-O
+humans NOUN B-O
+. PUNCT B-O
+
+We PRON B-O
+inserted VERB B-O
+the DET B-O
+CAN1 PROPN B-O
+and CCONJ B-O
+URA3 PROPN B-O
+genes NOUN B-O
+, PUNCT B-O
+two NUM B-O
+counter ADJ B-O
+- PUNCT B-O
+selectable ADJ B-O
+markers NOUN B-O
+, PUNCT B-O
+∼10 NUM B-O
+kb NOUN B-O
+from ADP B-O
+the DET B-O
+telomere NOUN B-O
+of ADP B-O
+ChrXV PROPN B-O
+- PUNCT B-O
+L PROPN B-O
+( PUNCT B-O
+Figure PROPN B-O
+1A NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+simultaneous ADJ B-O
+loss NOUN B-O
+of ADP B-O
+CAN1 PROPN B-O
+and CCONJ B-O
+URA3 PROPN B-O
+( PUNCT B-O
+detected VERB B-O
+on ADP B-O
+media NOUN B-O
+containing VERB B-O
+canavinine NOUN B-LF
+[ X B-O
+can PROPN B-AC
+] PUNCT B-O
+and CCONJ B-O
+5 NUM B-O
+- PUNCT B-O
+fluoro NOUN B-O
+- PUNCT B-O
+orotic ADJ B-O
+acid NOUN B-O
+[ X B-O
+5 NUM B-O
+- PUNCT B-O
+FOA NOUN B-O
+] PUNCT B-O
+) PUNCT B-O
+at ADP B-O
+this DET B-O
+locus NOUN B-O
+occurs VERB B-O
+at ADP B-O
+a DET B-O
+rate NOUN B-O
+of ADP B-O
+8.9 NUM B-O
+× PUNCT B-O
+10−8 NUM B-O
+( PUNCT B-O
+Table PROPN B-O
+1 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+approximately ADV B-O
+250 NUM B-O
+- PUNCT B-O
+fold ADJ B-O
+higher ADJ B-O
+than ADP B-O
+the DET B-O
+rate NOUN B-O
+observed VERB B-O
+at ADP B-O
+ChrV PROPN B-O
+- PUNCT B-O
+L PROPN B-O
+( PUNCT B-O
+3.5 NUM B-O
+× PUNCT B-O
+10−10 NUM B-O
+; PUNCT B-O
+Table PROPN B-O
+2 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Pilot NOUN B-O
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+exhaustive ADJ B-O
+sampling NOUN B-O
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+progressive ADJ B-O
+means NOUN B-O
+analysis NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+the DET B-O
+formula NOUN B-O
+of ADP B-O
+West PROPN B-O
+et PROPN B-O
+al PROPN B-O
+. PUNCT B-O
+
+, PUNCT B-O
+[ PUNCT B-O
+166 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+as ADP B-O
+well ADV B-O
+as ADP B-O
+a PRON B-O
+posteriori X B-O
+power NOUN B-O
+analysis NOUN B-O
+, PUNCT B-O
+using VERB B-O
+data NOUN B-O
+from ADP B-O
+our PRON B-O
+previous ADJ B-O
+studies NOUN B-O
+of ADP B-O
+cell NOUN B-O
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+axon NOUN B-O
+densities NOUN B-O
+, PUNCT B-O
+or CCONJ B-O
+tract NOUN B-O
+tracing NOUN B-O
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+pathways NOUN B-O
+, PUNCT B-O
+took VERB B-O
+into ADP B-O
+consideration NOUN B-O
+all DET B-O
+known VERB B-O
+and CCONJ B-O
+estimated VERB B-O
+variables NOUN B-O
+, PUNCT B-O
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+age NOUN B-O
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+sex NOUN B-O
+, PUNCT B-O
+postmortem ADJ B-LF
+interval NOUN I-LF
+( PUNCT B-O
+PMI PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+other ADJ B-O
+diagnoses NOUN B-O
+. PUNCT B-O
+
+A DET B-O
+series NOUN B-O
+of ADP B-O
+computer NOUN B-O
+- PUNCT B-O
+aided VERB B-O
+virtual ADJ B-O
+screening VERB B-O
+techniques NOUN B-O
+were AUX B-O
+utilized VERB B-O
+to PART B-O
+identify VERB B-O
+potential ADJ B-O
+agonists NOUN B-O
+of ADP B-O
+STING PROPN B-AC
+. PUNCT B-O
+
+Structure NOUN B-O
+- PUNCT B-O
+based VERB B-O
+screening VERB B-O
+using VERB B-O
+Libdock PROPN B-O
+was AUX B-O
+carried VERB B-O
+out ADP B-O
+followed VERB B-O
+by ADP B-O
+ADME PROPN B-AC
+( PUNCT B-O
+absorption NOUN B-LF
+, PUNCT I-LF
+distribution NOUN I-LF
+, PUNCT I-LF
+metabolism NOUN I-LF
+, PUNCT I-LF
+excretion NOUN I-LF
+) PUNCT B-O
+and CCONJ B-O
+toxicity NOUN B-O
+prediction NOUN B-O
+. PUNCT B-O
+
+Since SCONJ B-O
+the DET B-O
+absolute ADJ B-O
+precision NOUN B-O
+is AUX B-O
+depending VERB B-O
+on ADP B-O
+prevalence NOUN B-O
+of ADP B-O
+atrial ADJ B-LF
+fibrillation NOUN I-LF
+, PUNCT B-O
+which PRON B-O
+was AUX B-O
+low ADJ B-O
+in ADP B-O
+the DET B-O
+screened VERB B-O
+population NOUN B-O
+, PUNCT B-O
+one PRON B-O
+must AUX B-O
+consider VERB B-O
+sample NOUN B-O
+size NOUN B-O
+, PUNCT B-O
+i.e. X B-O
+what PRON B-O
+is AUX B-O
+the DET B-O
+absolute ADJ B-O
+precision NOUN B-O
+in ADP B-O
+the DET B-O
+validation NOUN B-O
+trial NOUN B-O
+with ADP B-O
+the DET B-O
+reported VERB B-O
+sample NOUN B-O
+size NOUN B-O
+and CCONJ B-O
+AF PROPN B-AC
+prevalence NOUN B-O
+? PUNCT B-O
+We PRON B-O
+also ADV B-O
+described VERB B-O
+the DET B-O
+dilutions NOUN B-O
+of ADP B-O
+the DET B-O
+antibody NOUN B-O
+in ADP B-O
+the DET B-O
+“ PUNCT B-O
+Results NOUN B-O
+” PUNCT B-O
+section NOUN B-O
+under ADP B-O
+the DET B-O
+heading NOUN B-O
+“ PUNCT B-O
+Detection NOUN B-O
+of ADP B-O
+anti ADJ B-O
+- PUNCT B-O
+FXIII/13 PROPN B-AC
+- PUNCT B-O
+A NOUN B-O
+autoantibodies NOUN B-O
+using VERB B-O
+enzyme NOUN B-LF
+- PUNCT I-LF
+linked VERB I-LF
+immunosorbent ADJ I-LF
+assay NOUN I-LF
+( PUNCT B-O
+ELISA PROPN B-AC
+) PUNCT B-O
+” PUNCT B-O
+( PUNCT B-O
+p.12 NOUN B-O
+, PUNCT B-O
+lane NOUN B-O
+3 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+They PRON B-O
+invade VERB B-O
+primary ADJ B-O
+tumors NOUN B-O
+, PUNCT B-O
+where SCONJ B-O
+they PRON B-O
+promote VERB B-O
+angiogenesis NOUN B-O
+, PUNCT B-O
+via ADP B-O
+Matrix PROPN B-LF
+Metaloproteinases PROPN I-LF
+( PUNCT B-O
+MMP PROPN B-AC
+) PUNCT B-O
+secretion NOUN B-O
+and CCONJ B-O
+Vascular PROPN B-LF
+Endothelial PROPN I-LF
+Growth PROPN I-LF
+Factor PROPN I-LF
+( PUNCT B-O
+VEGF PROPN B-AC
+) PUNCT B-O
+production NOUN B-O
+[ PUNCT B-O
+24 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+All DET B-O
+AmpC NOUN B-LF
+beta NOUN I-LF
+AmpC PROPN B-AC
+- PUNCT I-LF
+lactamase NOUN I-LF
+producing VERB B-O
+GNB PROPN B-AC
+were AUX B-O
+detected VERB B-O
+in ADP B-O
+urine NOUN B-O
+specimens NOUN B-O
+3.3 NUM B-O
+% PUNCT B-O
+( PUNCT B-O
+8/244 NUM B-O
+) PUNCT B-O
+and CCONJ B-O
+in ADP B-O
+patients NOUN B-O
+whose DET B-O
+age NOUN B-O
+group NOUN B-O
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+above ADP B-O
+61 NUM B-O
+years NOUN B-O
+( PUNCT B-O
+40.1 NUM B-O
+% PUNCT B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Temperature NOUN B-O
+data NOUN B-O
+such ADJ B-O
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+the DET B-O
+decadal ADJ B-O
+( PUNCT B-O
+10 NUM B-O
+- PUNCT B-O
+day NOUN B-O
+) PUNCT B-O
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+air NOUN B-O
+temperature NOUN B-O
+( PUNCT B-O
+DMDMAT PROPN B-AC
+) PUNCT B-O
+were AUX B-O
+obtained VERB B-O
+from ADP B-O
+a DET B-O
+nearby ADJ B-O
+weather NOUN B-O
+station NOUN B-O
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+statistical ADJ B-O
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+tick NOUN B-O
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+minimal ADJ B-LF
+infection NOUN I-LF
+rates NOUN I-LF
+( PUNCT B-O
+MIR PROPN B-AC
+) PUNCT B-O
+were AUX B-O
+calculated VERB B-O
+. PUNCT B-O
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+In ADP B-O
+the DET B-O
+case NOUN B-O
+of ADP B-O
+the DET B-O
+Schizophrenia PROPN B-LF
+( PUNCT B-O
+SZ PROPN B-AC
+) PUNCT B-O
+GWAS PROPN B-AC
+original ADJ B-O
+report NOUN B-O
+, PUNCT B-O
+16 NUM B-O
+% NOUN B-O
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+the DET B-O
+findings NOUN B-O
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+shown VERB B-O
+to PART B-O
+have VERB B-O
+brain NOUN B-O
+eQTL PROPN B-AC
+effects NOUN B-O
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+the DET B-O
+gene NOUN B-O
+level NOUN B-O
+[ PUNCT B-O
+1 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+but CCONJ B-O
+further ADJ B-O
+studies NOUN B-O
+are AUX B-O
+increasing VERB B-O
+this DET B-O
+number NOUN B-O
+[ PUNCT B-O
+6 NUM B-O
+, PUNCT B-O
+7 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+To PART B-O
+explore VERB B-O
+the DET B-O
+relationships NOUN B-O
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+HP1 PROPN B-AC
+and CCONJ B-O
+these DET B-O
+marks NOUN B-O
+, PUNCT B-O
+we PRON B-O
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+- PUNCT B-O
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+available ADJ B-O
+high ADJ B-O
+- PUNCT B-O
+resolution NOUN B-O
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+maps NOUN B-O
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+dimethylated VERB B-LF
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+3 NUM I-LF
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+4 NUM I-LF
+( PUNCT B-O
+H3K4me2 PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+H3.3 NOUN B-O
+, PUNCT B-O
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+generated VERB B-O
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+the DET B-O
+Drosophila PROPN B-O
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+cell NOUN B-O
+line NOUN B-O
+or CCONJ B-O
+in ADP B-O
+the DET B-O
+closely ADV B-O
+related VERB B-O
+S2 PROPN B-O
+cell NOUN B-O
+line NOUN B-O
+[ X B-O
+51,53 X B-O
+] X B-O
+( PUNCT B-O
+see VERB B-O
+Materials NOUN B-O
+and CCONJ B-O
+Methods PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+This DET B-O
+virus NOUN B-O
+quickly ADV B-O
+spread VERB B-O
+globally ADV B-O
+, PUNCT B-O
+and CCONJ B-O
+on ADP B-O
+June PROPN B-O
+11 NUM B-O
+, PUNCT B-O
+2009 NUM B-O
+, PUNCT B-O
+the DET B-O
+World PROPN B-LF
+Health PROPN I-LF
+Organization PROPN I-LF
+( PUNCT B-O
+WHO PROPN B-AC
+) PUNCT B-O
+declared VERB B-O
+a DET B-O
+pandemic NOUN B-O
+alert NOUN B-O
+phase NOUN B-O
+6 NUM B-O
+, PUNCT B-O
+indicating VERB B-O
+that SCONJ B-O
+the DET B-O
+first ADJ B-O
+influenza NOUN B-O
+pandemic NOUN B-O
+of ADP B-O
+the DET B-O
+21st ADJ B-O
+century NOUN B-O
+had AUX B-O
+begun VERB B-O
+[ X B-O
+1]–[3 X B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Between ADP B-O
+1990 NUM B-O
+and CCONJ B-O
+2014 NUM B-O
+the DET B-O
+world NOUN B-O
+prevalence NOUN B-O
+of ADP B-O
+cesarean ADJ B-LF
+section NOUN I-LF
+( PUNCT B-O
+CS PROPN B-AC
+) PUNCT B-O
+increased VERB B-O
+by ADP B-O
+285 NUM B-O
+% NOUN B-O
+( PUNCT B-O
+6.7 NUM B-O
+% NOUN B-O
+versus ADP B-O
+19.1 NUM B-O
+% NOUN B-O
+of ADP B-O
+all DET B-O
+births NOUN B-O
+) PUNCT B-O
+[ PUNCT B-O
+1 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+albeit SCONJ B-O
+with ADP B-O
+large ADJ B-O
+regional ADJ B-O
+disparities NOUN B-O
+. PUNCT B-O
+
+Note VERB B-O
+that SCONJ B-O
+as ADP B-O
+a DET B-O
+consequence NOUN B-O
+of ADP B-O
+standardization NOUN B-O
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+the DET B-O
+continuous ADJ B-O
+variables NOUN B-O
+( PUNCT B-O
+age NOUN B-O
+, PUNCT B-O
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+circumference NOUN B-O
+, PUNCT B-O
+fasting VERB B-O
+plasma NOUN B-O
+glucose NOUN B-O
+, PUNCT B-O
+total ADJ B-O
+- PUNCT B-O
+to ADP B-O
+- PUNCT B-O
+HDL NOUN B-O
+cholesterol NOUN B-O
+, PUNCT B-O
+24 NUM B-O
+- PUNCT B-O
+h NOUN B-O
+systolic ADJ B-O
+blood NOUN B-O
+pressure NOUN B-O
+) PUNCT B-O
+the DET B-O
+regression NOUN B-O
+coefficient NOUN B-O
+( PUNCT B-O
+B NOUN B-O
+) PUNCT B-O
+for ADP B-O
+continuous ADJ B-O
+variables NOUN B-O
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+the DET B-O
+standardized ADJ B-O
+beta NOUN B-O
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+
+* PUNCT B-O
+P<0.05 NUM B-O
+, PUNCT B-O
+SD PROPN B-AC
+, PUNCT B-O
+standard ADJ B-LF
+deviation NOUN I-LF
+; PUNCT B-O
+CI NOUN B-O
+, PUNCT B-O
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+HDL NOUN B-O
+, PUNCT B-O
+high ADJ B-O
+- PUNCT B-O
+density NOUN B-O
+lipoprotein NOUN B-O
+. PUNCT B-O
+
+For ADP B-O
+this DET B-O
+interim ADJ B-O
+analysis NOUN B-O
+, PUNCT B-O
+we PRON B-O
+excluded VERB B-O
+patients NOUN B-O
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+with ADP B-O
+different ADJ B-O
+therapies NOUN B-O
+other ADJ B-O
+than ADP B-O
+standard ADJ B-O
+chemotherapy NOUN B-O
+including VERB B-O
+anthracycline NOUN B-O
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+trastuzumab NOUN B-O
+( PUNCT B-O
+n NOUN B-O
+= SYM B-O
+2,929 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+patients NOUN B-O
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+no DET B-O
+left ADJ B-LF
+ventricular ADJ I-LF
+ejection NOUN I-LF
+fraction NOUN I-LF
+( PUNCT B-O
+LVEF PROPN B-AC
+) PUNCT B-O
+measurement NOUN B-O
+at ADP B-O
+baseline NOUN B-O
+( PUNCT B-O
+n NOUN B-O
+= SYM B-O
+918)or NUM B-O
+no DET B-O
+available ADJ B-O
+follow VERB B-O
+- PUNCT B-O
+up ADP B-O
+measurements NOUN B-O
+( PUNCT B-O
+n NOUN B-O
+= SYM B-O
+799 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+patients NOUN B-O
+with ADP B-O
+LVEF PROPN B-AC
+at ADP B-O
+baseline NOUN B-O
+< ADP B-O
+50 NUM B-O
+% NOUN B-O
+( PUNCT B-O
+n NOUN B-O
+= SYM B-O
+13 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+patients NOUN B-O
+with ADP B-O
+BMI PROPN B-AC
+< ADP B-O
+18.5 NUM B-O
+kg NOUN B-O
+/ SYM B-O
+m2 NOUN B-O
+( PUNCT B-O
+n NOUN B-O
+= SYM B-O
+32 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+patients NOUN B-O
+with ADP B-O
+evidence NOUN B-O
+of ADP B-O
+local ADJ B-O
+, PUNCT B-O
+regional ADJ B-O
+, PUNCT B-O
+or CCONJ B-O
+metastatic ADJ B-O
+recurrence NOUN B-O
+of ADP B-O
+BC PROPN B-AC
+( PUNCT B-O
+n NOUN B-O
+= SYM B-O
+181 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Meanwhile ADV B-O
+, PUNCT B-O
+it PRON B-O
+lowered VERB B-O
+malondialdehyde NOUN B-LF
+( PUNCT B-O
+MDA PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+nitric NOUN B-LF
+oxide NOUN I-LF
+( PUNCT B-O
+NO PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+nuclear ADJ B-LF
+factor NOUN I-LF
+erythroid NOUN I-LF
+2 NUM I-LF
+- PUNCT I-LF
+related VERB I-LF
+factor NOUN I-LF
+2 NUM I-LF
+( PUNCT B-O
+NRF-2 PROPN B-AC
+) PUNCT B-O
+levels NOUN B-O
+with ADP B-O
+restoration NOUN B-O
+of ADP B-O
+glutathione NOUN B-LF
+( PUNCT B-O
+GSH PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+glutathione NOUN B-LF
+peroxidase NOUN I-LF
+( PUNCT B-O
+GPx PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+CD PROPN B-AC
+, PUNCT B-O
+change NOUN B-LF
+- PUNCT I-LF
+detection NOUN I-LF
+. PUNCT B-O
+
+As SCONJ B-O
+the DET B-O
+transfer NOUN B-O
+of ADP B-O
+bacteria NOUN B-O
+to ADP B-O
+the DET B-O
+embryo NOUN B-O
+is AUX B-O
+being AUX B-O
+completed VERB B-O
+, PUNCT B-O
+expression NOUN B-O
+of ADP B-O
+the DET B-O
+Engrailed PROPN B-LF
+( PUNCT B-O
+En PROPN B-AC
+) PUNCT B-O
+protein NOUN B-O
+( PUNCT B-O
+FBgn0000577 NOUN B-O
+) PUNCT B-O
+( PUNCT B-O
+Patel PROPN B-O
+et NOUN B-O
+al NOUN B-O
+. PUNCT B-O
+
+1989 NUM B-O
+) PUNCT B-O
+is AUX B-O
+detected VERB B-O
+( PUNCT B-O
+Figure NOUN B-O
+1 NUM B-O
+G NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Knowledge NOUN B-LF
+translation NOUN I-LF
+( PUNCT B-O
+KT PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+one NUM B-O
+of ADP B-O
+a DET B-O
+host NOUN B-O
+of ADP B-O
+terms NOUN B-O
+( PUNCT B-O
+e.g. X B-O
+, PUNCT B-O
+implementation NOUN B-O
+, PUNCT B-O
+knowledge NOUN B-O
+transfer NOUN B-O
+) PUNCT B-O
+used VERB B-O
+to PART B-O
+describe VERB B-O
+“ PUNCT B-O
+a DET B-O
+dynamic ADJ B-O
+and CCONJ B-O
+iterative ADJ B-O
+process NOUN B-O
+that PRON B-O
+includes VERB B-O
+the DET B-O
+synthesis NOUN B-O
+, PUNCT B-O
+dissemination NOUN B-O
+, PUNCT B-O
+exchange NOUN B-O
+and CCONJ B-O
+ethically ADV B-O
+sound ADJ B-O
+application NOUN B-O
+of ADP B-O
+knowledge NOUN B-O
+to PART B-O
+improve VERB B-O
+health NOUN B-O
+, PUNCT B-O
+provide VERB B-O
+more ADV B-O
+effective ADJ B-O
+health NOUN B-O
+services NOUN B-O
+and CCONJ B-O
+products NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+strengthen VERB B-O
+the DET B-O
+healthcare NOUN B-O
+system NOUN B-O
+. PUNCT B-O
+
+”[6 X B-O
+] X B-O
+This DET B-O
+value NOUN B-O
+is AUX B-O
+in ADP B-O
+excellent ADJ B-O
+agreement NOUN B-O
+with ADP B-O
+the DET B-O
+expected VERB B-O
+molecular ADJ B-O
+weight NOUN B-O
+of ADP B-O
+the DET B-O
+holoenzyme NOUN B-O
+, PUNCT B-O
+28,705.88 NUM B-O
+Da PROPN B-AC
+. PUNCT B-O
+
+As ADP B-O
+an DET B-O
+independent ADJ B-O
+confirmation NOUN B-O
+of ADP B-O
+these DET B-O
+results NOUN B-O
+, PUNCT B-O
+an DET B-O
+electrospray NOUN B-LF
+ionization NOUN I-LF
+( PUNCT B-O
+ESI PROPN B-AC
+) PUNCT B-O
+mass NOUN B-O
+spectrum NOUN B-O
+was AUX B-O
+acquired VERB B-O
+for ADP B-O
+APS PROPN B-AC
+reductase NOUN B-O
+. PUNCT B-O
+
+Real ADJ B-O
+- PUNCT B-O
+time NOUN B-O
+reverse ADJ B-O
+transcription NOUN B-O
+PCR NOUN B-O
+( PUNCT B-O
+qPCR NOUN B-O
+) PUNCT B-O
+normalized VERB B-O
+to ADP B-O
+an DET B-O
+internal ADJ B-O
+reference NOUN B-LF
+gene NOUN I-LF
+( PUNCT B-O
+RG PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+is AUX B-O
+a DET B-O
+frequently ADV B-O
+used VERB B-O
+method NOUN B-O
+for ADP B-O
+quantifying VERB B-O
+gene NOUN B-O
+expression NOUN B-O
+changes NOUN B-O
+in ADP B-O
+neuroscience NOUN B-O
+. PUNCT B-O
+
+Consensus NOUN B-O
+documents NOUN B-O
+developed VERB B-O
+by ADP B-O
+professional ADJ B-O
+societies NOUN B-O
+from ADP B-O
+the DET B-O
+US PROPN B-O
+, PUNCT B-O
+Europe PROPN B-O
+, PUNCT B-O
+and CCONJ B-O
+Canada PROPN B-O
+[ X B-O
+9–12 NUM B-O
+] X B-O
+have AUX B-O
+cautioned VERB B-O
+against ADP B-O
+generic ADJ B-O
+immunosuppressant ADJ B-O
+use NOUN B-O
+, PUNCT B-O
+citing VERB B-O
+( PUNCT B-O
+1 X B-O
+) PUNCT B-O
+the DET B-O
+lack NOUN B-O
+of ADP B-O
+data NOUN B-O
+in ADP B-O
+transplant NOUN B-O
+recipients NOUN B-O
+, PUNCT B-O
+especially ADV B-O
+“ PUNCT B-O
+high ADJ B-O
+risk NOUN B-O
+” PUNCT B-O
+transplant NOUN B-O
+recipients NOUN B-O
+; PUNCT B-O
+( PUNCT B-O
+2 X B-O
+) PUNCT B-O
+the DET B-O
+need NOUN B-O
+to PART B-O
+implement VERB B-O
+stricter ADJ B-O
+bioequivalence NOUN B-O
+standards NOUN B-O
+, PUNCT B-O
+as SCONJ B-O
+tacrolimus PROPN B-O
+is AUX B-O
+a DET B-O
+narrow ADJ B-LF
+therapeutic ADJ I-LF
+index NOUN I-LF
+( PUNCT B-O
+NTI PROPN B-AC
+) PUNCT B-O
+drug NOUN B-O
+for ADP B-O
+which PRON B-O
+small ADJ B-O
+changes NOUN B-O
+in ADP B-O
+dose NOUN B-O
+or CCONJ B-O
+exposure NOUN B-O
+can AUX B-O
+result VERB B-O
+in ADP B-O
+therapeutic ADJ B-O
+failure NOUN B-O
+or CCONJ B-O
+toxicity NOUN B-O
+; PUNCT B-O
+and CCONJ B-O
+( PUNCT B-O
+3 X B-O
+) PUNCT B-O
+the DET B-O
+lack NOUN B-O
+of ADP B-O
+bioequivalence NOUN B-O
+data NOUN B-O
+between ADP B-O
+generics NOUN B-O
+. PUNCT B-O
+
+Ductal ADJ B-LF
+carcinoma NOUN I-LF
+in ADP I-LF
+situ NOUN I-LF
+( PUNCT B-O
+DCIS PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+a DET B-O
+noninvasive ADJ B-O
+nonobligate ADJ B-O
+precursor NOUN B-O
+of ADP B-O
+breast NOUN B-O
+cancer NOUN B-O
+, PUNCT B-O
+accounts VERB B-O
+for ADP B-O
+about ADV B-O
+25 NUM B-O
+% NOUN B-O
+of ADP B-O
+all DET B-O
+breast NOUN B-O
+cancer NOUN B-O
+cases NOUN B-O
+[ PUNCT B-O
+38 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Indeed ADV B-O
+, PUNCT B-O
+as SCONJ B-O
+expected VERB B-O
+, PUNCT B-O
+pretreatment NOUN B-O
+of ADP B-O
+Hsp26 PROPN B-O
+for ADP B-O
+10 NUM B-O
+min NOUN B-O
+at ADP B-O
+45 NUM B-O
+° NOUN B-O
+C NOUN B-O
+increased VERB B-O
+the DET B-O
+ability NOUN B-O
+of ADP B-O
+Hsp26 PROPN B-O
+to ADP B-O
+suppress VERB B-O
+aggregation NOUN B-O
+of ADP B-O
+glutamate NOUN B-LF
+dehydrogenase NOUN I-LF
+( PUNCT B-O
+GDH PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+Figure PROPN B-O
+6D NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+By ADP B-O
+contrast NOUN B-O
+, PUNCT B-O
+the DET B-O
+same ADJ B-O
+pretreatment NOUN B-O
+reduced VERB B-O
+the DET B-O
+ability NOUN B-O
+of ADP B-O
+Hsp26 PROPN B-O
+to ADP B-O
+inhibit VERB B-O
+spontaneous ADJ B-O
+NM NOUN B-O
+assembly NOUN B-O
+( PUNCT B-O
+Figure PROPN B-O
+6D NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Thus ADV B-O
+, PUNCT B-O
+at ADP B-O
+elevated VERB B-O
+temperatures NOUN B-O
+Hsp26 PROPN B-O
+might AUX B-O
+switch VERB B-O
+from ADP B-O
+inhibiting VERB B-O
+prion NOUN B-O
+assembly NOUN B-O
+to ADP B-O
+suppressing VERB B-O
+aggregation NOUN B-O
+of ADP B-O
+denatured VERB B-O
+substrates NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+results NOUN B-O
+demonstrated VERB B-O
+that SCONJ B-O
+this DET B-O
+human ADJ B-O
+LCM PROPN B-AC
+gene NOUN B-O
+set NOUN B-O
+was AUX B-O
+significantly ADV B-O
+decreased VERB B-O
+in ADP B-O
+the DET B-O
+STHdhQ111 NOUN B-O
+/ SYM B-O
+Q111 NOUN B-O
+cells NOUN B-O
+( PUNCT B-O
+enrichment NOUN B-LF
+score NOUN I-LF
+[ X B-O
+ES PROPN B-AC
+] X B-O
+0.51 NUM B-O
+, PUNCT B-O
+p NOUN B-O
+- NOUN B-O
+value NOUN B-O
+0.000 NUM B-O
+, PUNCT B-O
+FDR PROPN B-AC
+q NOUN B-O
+- NOUN B-O
+value NOUN B-O
+0.180 NUM B-O
+) PUNCT B-O
+but CCONJ B-O
+was AUX B-O
+not PART B-O
+altered VERB B-O
+in ADP B-O
+the DET B-O
+3 PROPN B-AC
+treated VERB B-O
+cells NOUN B-O
+( PUNCT B-O
+-NPES PROPN B-AC
+0.38 NUM B-O
+, PUNCT B-O
+p NOUN B-O
+- NOUN B-O
+value NOUN B-O
+0.271 NUM B-O
+, PUNCT B-O
+FDR PROPN B-AC
+q NOUN B-O
+- NOUN B-O
+value NOUN B-O
+0.713 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+BP PROPN B-AC
+: PUNCT B-O
+blood NOUN B-LF
+pressure NOUN I-LF
+. PUNCT B-O
+
+In ADP B-O
+pemphigus NOUN B-LF
+vulgaris PROPN I-LF
+( PUNCT B-O
+PV PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+the DET B-O
+most ADV B-O
+common ADJ B-O
+clinical ADJ B-O
+variant NOUN B-O
+of ADP B-O
+pemphigus NOUN B-O
+, PUNCT B-O
+several ADJ B-O
+in ADP B-O
+vitro ADJ B-O
+and CCONJ B-O
+in ADP B-O
+vivo ADJ B-O
+studies NOUN B-O
+demonstrated VERB B-O
+the DET B-O
+critical ADJ B-O
+role NOUN B-O
+of ADP B-O
+Dsg3 NOUN B-O
+- NOUN B-O
+specific ADJ B-O
+CD4 NOUN B-O
++ NOUN B-O
+T NOUN B-O
+cells NOUN B-O
+in ADP B-O
+the DET B-O
+generation NOUN B-O
+of ADP B-O
+Dsg3 NOUN B-O
+- NOUN B-O
+specific ADJ B-O
+auto-ab PROPN B-AC
+[ X B-O
+4–9 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+I PRON B-O
+employed VERB B-O
+a DET B-O
+Z NOUN B-O
+- PUNCT B-O
+score NOUN B-O
+measure NOUN B-O
+of ADP B-O
+structural ADJ B-O
+proximity NOUN B-O
+as ADP B-O
+weight NOUN B-O
+for ADP B-O
+the DET B-O
+edges NOUN B-O
+to PART B-O
+create VERB B-O
+a DET B-O
+protein NOUN B-LF
+domains NOUN I-LF
+universe NOUN I-LF
+graph NOUN I-LF
+( PUNCT B-O
+PDUG PROPN B-AC
+[ PUNCT B-O
+19 NUM B-O
+] PUNCT B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+VHL PROPN B-AC
+mutation NOUN B-O
+diminishes VERB B-O
+VHL PROPN B-AC
+'s PART B-O
+binding VERB B-O
+affinity NOUN B-O
+for ADP B-O
+hydroxylated VERB B-O
+HIF PROPN B-AC
+- PUNCT B-O
+α PUNCT B-O
+, PUNCT B-O
+thereby ADV B-O
+partially ADV B-O
+inhibiting VERB B-O
+HIF PROPN B-AC
+- PUNCT B-O
+α PUNCT B-O
+degradation NOUN B-O
+and CCONJ B-O
+pathologically ADV B-O
+up ADV B-O
+- PUNCT B-O
+regulating VERB B-O
+HIF PROPN B-AC
+target NOUN B-O
+genes NOUN B-O
+including VERB B-O
+erythropoietin NOUN B-LF
+( PUNCT B-O
+EPO PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+8 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+BMI PROPN B-AC
+, PUNCT B-O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT B-O
+HR NOUN B-O
+, PUNCT B-O
+hazard NOUN B-O
+ratio NOUN B-O
+; PUNCT B-O
+ICS PROPN B-AC
+, PUNCT B-O
+inhaled VERB B-LF
+corticosteroid NOUN I-LF
+; PUNCT B-O
+LABA PROPN B-AC
+, PUNCT B-O
+long ADV B-LF
+- PUNCT I-LF
+acting VERB I-LF
+beta NOUN I-LF
+- PUNCT I-LF
+agonist NOUN I-LF
+. PUNCT B-O
+
+Information NOUN B-O
+is AUX B-O
+available ADJ B-O
+from ADP B-O
+Avert PROPN B-O
+, PUNCT B-O
+an DET B-O
+international ADJ B-O
+AIDS PROPN B-O
+charity NOUN B-O
+, PUNCT B-O
+on ADP B-O
+many ADJ B-O
+aspects NOUN B-O
+of ADP B-O
+HIV PROPN B-O
+/ SYM B-O
+AIDS PROPN B-O
+, PUNCT B-O
+including VERB B-O
+information NOUN B-O
+on ADP B-O
+antiretroviral ADJ B-LF
+drugs NOUN B-O
+and CCONJ B-O
+on ADP B-O
+universal ADJ B-O
+access NOUN B-O
+to ADP B-O
+ARV PROPN B-AC
+therapy NOUN B-O
+; PUNCT B-O
+Avert PROPN B-O
+also ADV B-O
+provides VERB B-O
+personal ADJ B-O
+stories NOUN B-O
+about ADP B-O
+living VERB B-O
+with ADP B-O
+HIV PROPN B-O
+/ SYM B-O
+AIDS PROPN B-O
+The DET B-O
+efficiency NOUN B-O
+of ADP B-O
+siRNA NOUN B-O
+delivery NOUN B-O
+was AUX B-O
+checked VERB B-O
+with ADP B-O
+fluorescent ADJ B-O
+siGLO NOUN B-O
+. PUNCT B-O
+
+Among ADP B-O
+these DET B-O
+siRNAs NOUN B-O
+, PUNCT B-O
+only ADV B-O
+those PRON B-O
+silencing VERB B-O
+the DET B-O
+Ca2 NOUN B-O
++ NOUN B-O
+-independent ADJ B-O
+Group PROPN B-LF
+VIIIA PROPN I-LF
+( PUNCT B-O
+GVIIIA)-PLA2 PROPN B-AC
+inhibited VERB B-O
+VSVG PROPN B-AC
+transport NOUN B-O
+, PUNCT B-O
+resulting VERB B-O
+in ADP B-O
+accumulation NOUN B-O
+of ADP B-O
+cargo NOUN B-O
+within ADP B-O
+the DET B-O
+Golgi PROPN B-O
+complex NOUN B-O
+( PUNCT B-O
+Figure NOUN B-O
+8L NUM B-O
+and CCONJ B-O
+8P NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Strikingly ADV B-O
+, PUNCT B-O
+this DET B-O
+PLA2 PROPN B-AC
+isoform NOUN B-O
+has AUX B-O
+been AUX B-O
+detected VERB B-O
+by ADP B-O
+others NOUN B-O
+at ADP B-O
+the DET B-O
+Golgi PROPN B-O
+membranes NOUN B-O
+and CCONJ B-O
+appears VERB B-O
+to PART B-O
+be AUX B-O
+important ADJ B-O
+for ADP B-O
+maintenance NOUN B-O
+of ADP B-O
+the DET B-O
+tubular ADJ B-O
+elements NOUN B-O
+of ADP B-O
+the DET B-O
+Golgi PROPN B-O
+complex NOUN B-O
+( PUNCT B-O
+W. PROPN B-O
+The DET B-O
+main ADJ B-O
+outcome NOUN B-O
+is AUX B-O
+whether SCONJ B-O
+baseline NOUN B-O
+participants NOUN B-O
+received VERB B-O
+RPC PROPN B-AC
+( PUNCT B-O
+includes VERB B-O
+both CCONJ B-O
+pan ADJ B-O
+- PUNCT B-O
+retinal ADJ B-LF
+photocoagulation NOUN I-LF
+and CCONJ B-O
+focal ADJ B-O
+retinal ADJ B-O
+treatment NOUN B-O
+for ADP B-O
+macular ADJ B-O
+edema NOUN B-O
+) PUNCT B-O
+during ADP B-O
+the DET B-O
+follow NOUN B-O
+- PUNCT B-O
+up ADP B-O
+period NOUN B-O
+, PUNCT B-O
+which PRON B-O
+is AUX B-O
+an DET B-O
+indicator NOUN B-O
+of ADP B-O
+progression NOUN B-O
+to ADP B-O
+sNPDR PROPN B-AC
+or CCONJ B-O
+PDR PROPN B-AC
+. PUNCT B-O
+
+A DET B-O
+participant NOUN B-O
+who PRON B-O
+had AUX B-O
+at ADV B-O
+least ADV B-O
+one NUM B-O
+retinal ADJ B-O
+laser NOUN B-O
+treatment NOUN B-O
+record NOUN B-O
+in ADP B-O
+the DET B-O
+MBS PROPN B-AC
+database NOUN B-O
+( PUNCT B-O
+MBS PROPN B-AC
+code NOUN B-O
+for ADP B-O
+RPC PROPN B-AC
+: PUNCT B-O
+42809 NUM B-O
+) PUNCT B-O
+were AUX B-O
+defined VERB B-O
+as SCONJ B-O
+had AUX B-O
+undergone VERB B-O
+RPC PROPN B-AC
+. PUNCT B-O
+
+The DET B-O
+date NOUN B-O
+of ADP B-O
+first ADJ B-O
+laser NOUN B-O
+treatment NOUN B-O
+was AUX B-O
+utilized VERB B-O
+for ADP B-O
+analysis NOUN B-O
+if SCONJ B-O
+the DET B-O
+patient NOUN B-O
+underwent VERB B-O
+multiple ADJ B-O
+RPC PROPN B-AC
+treatments NOUN B-O
+. PUNCT B-O
+
+Chronic ADJ B-O
+airflow NOUN B-O
+limitation NOUN B-O
+was AUX B-O
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+5th ADJ B-O
+percentile NOUN B-O
+( PUNCT B-O
+lower ADJ B-O
+limit NOUN B-O
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+normal ADJ B-O
+; PUNCT B-O
+LLN PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Diffusing VERB B-LF
+lung NOUN I-LF
+capacity NOUN I-LF
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+carbon NOUN I-LF
+monoxide NOUN I-LF
+( PUNCT B-O
+DLCO PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+the DET B-O
+DLCO PROPN B-AC
+corrected VERB B-O
+for ADP B-O
+lung NOUN B-O
+volume NOUN B-O
+( PUNCT B-O
+DLCO PROPN B-AC
+) PUNCT B-O
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+a DET B-O
+single ADJ B-O
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+carbon NOUN B-O
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+diffusion NOUN B-O
+test NOUN B-O
+and CCONJ B-O
+were AUX B-O
+adjusted VERB B-O
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+plasma NOUN B-O
+haemoglobin NOUN B-O
+level.[20 NOUN B-O
+] X B-O
+Inspiratory ADJ B-LF
+capacity NOUN I-LF
+( PUNCT B-O
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+capacity NOUN I-LF
+( PUNCT B-O
+TLC PROPN B-AC
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+minus CCONJ B-O
+the DET B-O
+functional ADJ B-LF
+residual ADJ I-LF
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+( PUNCT B-O
+FRC PROPN B-AC
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+. PUNCT B-O
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+All DET B-O
+lung NOUN B-O
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+measures NOUN B-O
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+( PUNCT B-O
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+formula NOUN B-O
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+( PUNCT B-O
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+−3.6 NUM B-O
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+( PUNCT B-O
+UI PROPN B-AC
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+−6.1 NUM B-O
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+−0.6 NUM B-O
+% NOUN B-O
+] PUNCT B-O
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+−3.3 NUM B-O
+% NOUN B-O
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+−5.1 NUM B-O
+% NOUN B-O
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+pricing NOUN B-O
+, NOUN B-O
+−10.3 NUM B-O
+% NOUN B-O
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+−10.3 NUM B-O
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+−7.0 NUM B-O
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+) PUNCT B-O
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+professional ADJ B-O
+/ SYM B-O
+managerial ADJ B-O
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+groups NOUN B-O
+( PUNCT B-O
+current ADJ B-O
+tax NOUN B-O
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+−1.8 NUM B-O
+% NOUN B-O
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+UI PROPN B-AC
+−4.7 NUM B-O
+% NOUN B-O
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++1.6 NUM B-O
+% NOUN B-O
+] PUNCT B-O
+; PUNCT B-O
+value NOUN B-O
+- PUNCT B-O
+based VERB B-O
+tax NOUN B-O
+, NOUN B-O
+−1.9 NUM B-O
+% NOUN B-O
+[ PUNCT B-O
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+−3.6 NUM B-O
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+% NOUN B-O
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++4.0 NUM B-O
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+−5.6 NUM B-O
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++3.6 NUM B-O
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+) PUNCT B-O
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+Chronic ADJ B-O
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+C PROPN I-LF
+virus NOUN I-LF
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+HCV PROPN B-AC
+) PUNCT B-O
+infection NOUN B-O
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+leading VERB B-O
+cause NOUN B-O
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+cirrhosis NOUN B-O
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+liver NOUN B-O
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+hepatocellular ADJ B-LF
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+1 NUM B-O
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+2 NUM B-O
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+
+DUSP1 PROPN B-AC
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+MAPK PROPN B-AC
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+, PUNCT B-O
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+osteolysis NOUN B-O
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+cartilage NOUN B-O
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+studies NOUN B-O
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+mouse NOUN B-O
+models NOUN B-O
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+lipopolysaccharide NOUN B-O
+( PUNCT B-O
+LPS PROPN B-AC
+) PUNCT B-O
+induced VERB B-O
+inflammatory ADJ B-O
+bone NOUN B-O
+loss NOUN B-O
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+collagen NOUN B-LF
+induced VERB I-LF
+arthritis NOUN I-LF
+( PUNCT B-O
+CIA PROPN B-AC
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+16,19,20 NUM B-O
+] PUNCT B-O
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+Genomic ADJ B-O
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+young ADJ B-O
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+a DET B-O
+modified VERB B-O
+cetyltrimethyl NOUN B-LF
+ammonium NOUN I-LF
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+( PUNCT B-O
+CTAB PROPN B-AC
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+method NOUN B-O
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+
+The DET B-O
+median ADJ B-O
+age NOUN B-O
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+first ADJ B-O
+admission NOUN B-O
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+( PUNCT B-O
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+IQR PROPN B-AC
+] X B-O
+2–14 NUM B-O
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+, PUNCT B-O
+and CCONJ B-O
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+commonest ADJ B-O
+code NOUN B-O
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+to ADP B-O
+the DET B-O
+first ADJ B-O
+and CCONJ B-O
+all DET B-O
+admissions NOUN B-O
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+urinary ADJ B-LF
+tract NOUN I-LF
+infection NOUN I-LF
+( PUNCT B-O
+UTI PROPN B-AC
+; PUNCT B-O
+ICD-10 PROPN B-AC
+codes NOUN B-O
+N39.0 NUM B-O
+, PUNCT B-O
+N39.1 NUM B-O
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+or CCONJ B-O
+P39.3 NUM B-O
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+RS PROPN B-AC
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+retrospective ADJ B-LF
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+These DET B-O
+two NUM B-O
+regions NOUN B-O
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+the DET B-O
+VE PROPN B-AC
+also ADV B-O
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+differences NOUN B-O
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+localisation NOUN B-O
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+the DET B-O
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+F PROPN B-O
+- NOUN B-O
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+IIA PROPN B-O
+, PUNCT B-O
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+Planar PROPN B-LF
+Cell PROPN I-LF
+Polarity PROPN I-LF
+( PUNCT B-O
+PCP PROPN B-AC
+) PUNCT B-O
+signalling NOUN B-O
+molecules NOUN B-O
+Dishevelled-2 PROPN B-LF
+( PUNCT B-O
+Dvl-2 PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+Vangl2 PROPN B-O
+[ PUNCT B-O
+20 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
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+Human ADJ B-O
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+mouse NOUN B-O
+B PROPN B-O
+cells NOUN B-O
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+with ADP B-O
+membrane NOUN B-O
+- PUNCT B-O
+tethered VERB B-O
+or CCONJ B-O
+soluble ADJ B-O
+mB PROPN B-O
+- PUNCT B-O
+Fab′–anti NOUN B-O
+- PUNCT B-O
+Ig NOUN B-O
+plus CCONJ B-O
+streptavidin NOUN B-O
+before ADP B-O
+staining VERB B-O
+for ADP B-O
+phosphorylated VERB B-LF
+WASP NOUN I-LF
+WASP PROPN B-AC
+( PUNCT B-O
+pWASP PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+N-WASP PROPN B-AC
+( PUNCT B-O
+pN PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Using VERB B-O
+total ADJ B-O
+internal ADJ B-O
+reflection NOUN B-O
+fluorescence NOUN B-O
+microscopy NOUN B-O
+( PUNCT B-O
+TIRFM PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+we PRON B-O
+analyzed VERB B-O
+the DET B-O
+distribution NOUN B-O
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+the DET B-O
+relative ADJ B-O
+levels NOUN B-O
+of ADP B-O
+-WASPpWASP PROPN B-AC
+and CCONJ B-O
+pN PROPN B-AC
+at ADP B-O
+the DET B-O
+surface NOUN B-O
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+B PROPN B-O
+cells NOUN B-O
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+contact NOUN B-O
+with ADP B-O
+the DET B-O
+mB PROPN B-O
+- PUNCT B-O
+Fab′–anti NOUN B-O
+- PUNCT B-O
+Ig NOUN B-O
+– PUNCT B-O
+tethered VERB B-O
+lipid NOUN B-O
+bilayer NOUN B-O
+( PUNCT B-O
+B PROPN B-O
+- PUNCT B-O
+cell NOUN B-O
+contact NOUN B-O
+zone NOUN B-O
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+This DET B-O
+study NOUN B-O
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+Strengthening VERB B-LF
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+Observational PROPN I-LF
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+( PUNCT B-O
+STROBE PROPN B-AC
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+guidelines NOUN B-O
+( PUNCT B-O
+S1 PROPN B-O
+STROBE PROPN B-AC
+Checklist PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
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+SARS PROPN B-AC
+-CoV-2 PROPN B-AC
+entry NOUN B-O
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+cells NOUN B-O
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+the DET B-O
+binding NOUN B-O
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+the DET B-O
+viral ADJ B-O
+spike NOUN B-O
+( PUNCT B-O
+S NOUN B-O
+) PUNCT B-O
+protein NOUN B-O
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+cognate NOUN B-O
+receptor NOUN B-O
+angiotensin NOUN B-LF
+converting VERB I-LF
+enzyme NOUN I-LF
+II NUM I-LF
+( PUNCT B-O
+ACE2 PROPN B-AC
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+the DET B-O
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+surface NOUN B-O
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+This DET B-O
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+Strengthening VERB B-LF
+the DET I-LF
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+Studies PROPN I-LF
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+Epidemiology PROPN I-LF
+( PUNCT B-O
+STROBE PROPN B-AC
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+guidelines NOUN B-O
+( PUNCT B-O
+S1 PROPN B-O
+STROBE PROPN B-AC
+Checklist PROPN B-O
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+[ PUNCT B-O
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+As ADP B-O
+a DET B-O
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+line NOUN B-O
+, PUNCT B-O
+countries NOUN B-O
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+Food PROPN B-LF
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+Agriculture PROPN I-LF
+Organization PROPN I-LF
+( PUNCT B-O
+FAO PROPN B-AC
+) PUNCT B-O
+advice NOUN B-O
+[ X B-O
+6 X B-O
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+withdraw VERB B-O
+the DET B-O
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+toxic ADJ B-O
+WHO PROPN B-AC
+/ SYM B-O
+US PROPN B-O
+Environmental PROPN B-LF
+Protection PROPN I-LF
+Agency PROPN I-LF
+( PUNCT B-O
+EPA PROPN B-AC
+) PUNCT B-O
+class NOUN B-O
+I NUM B-O
+pesticides NOUN B-O
+( PUNCT B-O
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+Table NOUN B-O
+1 NUM B-O
+for ADP B-O
+description NOUN B-O
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+toxicity NOUN B-O
+classifications NOUN B-O
+) PUNCT B-O
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+Patients NOUN B-O
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+diagnostic ADJ B-O
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+assessment NOUN B-O
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+Scale PROPN I-LF
+( PUNCT B-O
+ESS PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+24 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
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+resonance NOUN B-O
+imaging NOUN B-O
+, PUNCT B-O
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+Test PROPN I-LF
+( PUNCT B-O
+MSLT PROPN B-AC
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+, PUNCT B-O
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+video NOUN B-O
+- PUNCT B-O
+documentation NOUN B-O
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+antigen NOUN I-LF
+( PUNCT B-O
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+typing NOUN B-O
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+CSF PROPN B-O
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+Although SCONJ B-O
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+complete ADJ B-O
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+IAR PROPN B-AC
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+74 NUM B-O
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+, PUNCT B-O
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+drug NOUN B-O
+- PUNCT B-O
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+acute ADJ B-O
+inflammatory ADJ B-O
+vesiculobullous ADJ B-O
+reactions NOUN B-O
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+the DET B-O
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+mucous ADJ B-O
+membranes NOUN B-O
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+the DET B-O
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+
+Previous ADJ B-O
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+controls NOUN I-LF
+( PUNCT B-O
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+[ PUNCT B-O
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+Identification NOUN B-O
+of ADP B-O
+new ADJ B-O
+genes NOUN B-O
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+the DET B-O
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+and CCONJ B-O
+placement NOUN B-O
+of ADP B-O
+all DET B-O
+genes NOUN B-O
+, PUNCT B-O
+along ADP B-O
+with ADP B-O
+genetic ADJ B-O
+markers NOUN B-O
+, PUNCT B-O
+on ADP B-O
+a DET B-O
+physical ADJ B-O
+assembly NOUN B-O
+has AUX B-O
+greatly ADV B-O
+aided VERB B-O
+in ADP B-O
+the DET B-O
+search NOUN B-O
+for ADP B-O
+phenotypically ADV B-O
+important ADJ B-O
+genes NOUN B-O
+in ADP B-O
+both CCONJ B-O
+quantitative ADJ B-LF
+trait NOUN I-LF
+loci NOUN I-LF
+( PUNCT B-O
+QTL PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+mutagenesis NOUN B-O
+- PUNCT B-O
+based VERB B-O
+mapping NOUN B-O
+. PUNCT B-O
+
+Individuals NOUN B-O
+can AUX B-O
+be AUX B-O
+diagnosed VERB B-O
+when SCONJ B-O
+they PRON B-O
+develop VERB B-O
+symptoms NOUN B-O
+and CCONJ B-O
+present VERB B-O
+at ADP B-O
+a DET B-O
+clinic NOUN B-O
+, PUNCT B-O
+or CCONJ B-O
+when SCONJ B-O
+they PRON B-O
+are AUX B-O
+referred VERB B-O
+from ADP B-O
+an DET B-O
+antenatal ADJ B-LF
+clinic NOUN I-LF
+( PUNCT B-O
+ANC PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+or CCONJ B-O
+when SCONJ B-O
+they PRON B-O
+voluntarily ADV B-O
+get AUX B-O
+tested VERB B-O
+for ADP B-O
+HIV PROPN B-O
+( PUNCT B-O
+voluntary ADJ B-LF
+counselling NOUN I-LF
+and CCONJ I-LF
+testing NOUN I-LF
+, PUNCT B-O
+VCT PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+For ADP B-O
+simplicity NOUN B-O
+, PUNCT B-O
+we PRON B-O
+investigated VERB B-O
+circumstances NOUN B-O
+that PRON B-O
+range VERB B-O
+from ADP B-O
+the DET B-O
+worst ADJ B-O
+- PUNCT B-O
+case NOUN B-O
+to ADP B-O
+the DET B-O
+achievable ADJ B-O
+best ADJ B-O
+- PUNCT B-O
+case NOUN B-O
+scenario NOUN B-O
+. PUNCT B-O
+
+TBC PROPN B-AC
+, PUNCT B-O
+Tre2 PROPN B-LF
+- PUNCT I-LF
+Bub2 PROPN I-LF
+- PUNCT I-LF
+Cdc16 PROPN I-LF
+. PUNCT B-O
+
+* PUNCT B-O
+* PUNCT B-O
+* PUNCT B-O
+p NOUN B-O
+< SYM B-O
+0.001 NUM B-O
+LAD PROPN B-AC
+, PUNCT B-O
+left ADJ B-LF
+atrial ADJ I-LF
+diameter NOUN I-LF
+; PUNCT B-O
+LVDd PROPN B-AC
+, PUNCT B-O
+left ADJ B-LF
+ventricular ADJ I-LF
+end NOUN I-LF
+- PUNCT I-LF
+diastolic ADJ I-LF
+diameter NOUN I-LF
+; PUNCT B-O
+LVDs PROPN B-AC
+, PUNCT B-O
+left ADJ B-LF
+ventricular ADJ I-LF
+end NOUN I-LF
+- PUNCT I-LF
+systolic ADJ I-LF
+diameter NOUN I-LF
+; PUNCT B-O
+IVSth PROPN B-AC
+, PUNCT B-O
+intraventricular ADJ B-LF
+septum NOUN I-LF
+thickness NOUN I-LF
+; PUNCT B-O
+PWth PROPN B-AC
+, PUNCT B-O
+posterior ADJ B-LF
+wall NOUN I-LF
+thickness NOUN I-LF
+; PUNCT B-O
+LVEF PROPN B-AC
+, PUNCT B-O
+LV NOUN B-LF
+ejection NOUN I-LF
+LV PROPN B-AC
+fraction NOUN I-LF
+; PUNCT B-O
+LVM PROPN B-AC
+, PUNCT B-O
+LV NOUN B-LF
+mass NOUN I-LF
+LV PROPN B-AC
+; PUNCT B-O
+LVMI PROPN B-AC
+, PUNCT B-O
+LV NOUN B-LF
+mass NOUN I-LF
+LV PROPN B-AC
+index NOUN I-LF
+; PUNCT B-O
+E PROPN B-AC
+/ SYM B-O
+e NOUN B-O
+’ PUNCT B-O
+, PUNCT B-O
+the DET B-O
+ratio NOUN B-O
+of ADP B-O
+early ADJ B-LF
+- PUNCT I-LF
+diastolic ADJ I-LF
+left ADJ I-LF
+ventricular ADJ I-LF
+inflow ADJ I-LF
+velocity NOUN I-LF
+( PUNCT B-O
+E PROPN B-AC
+) PUNCT B-O
+to ADP B-O
+early ADJ B-O
+- PUNCT B-O
+diastolic ADJ B-O
+mitral ADJ B-O
+annular ADJ B-O
+velocity NOUN B-O
+( PUNCT B-O
+e′ NOUN B-O
+): PUNCT B-O
+LAVI PROPN B-AC
+, PUNCT B-O
+left ADJ B-LF
+atrial ADJ I-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT B-O
+other ADJ B-O
+abbreviations NOUN B-O
+as ADP B-O
+in ADP B-O
+Table NOUN B-O
+2 NUM B-O
+. PUNCT B-O
+
+LDL PROPN B-AC
+, PUNCT B-O
+low ADJ B-LF
+- PUNCT I-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+. PUNCT B-O
+
+( PUNCT B-O
+A X B-O
+) PUNCT B-O
+Confocal ADJ B-O
+fluorescence NOUN B-O
+image NOUN B-O
+of ADP B-O
+miniSOG PROPN B-AC
+targeted VERB B-O
+to ADP B-O
+the DET B-O
+mitochondria NOUN B-O
+in ADP B-O
+body NOUN B-O
+wall NOUN B-O
+muscles NOUN B-O
+of ADP B-O
+C. NOUN B-O
+elegans NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+B X B-O
+– PUNCT B-O
+C NOUN B-O
+) PUNCT B-O
+Thin ADJ B-O
+section NOUN B-O
+EM PROPN B-AC
+images NOUN B-O
+of ADP B-O
+a DET B-O
+portion NOUN B-O
+of ADP B-O
+C. NOUN B-O
+elegans NOUN B-O
+showing VERB B-O
+a DET B-O
+subset NOUN B-O
+of ADP B-O
+labeled VERB B-O
+mitochondria NOUN B-O
+in ADP B-O
+the DET B-O
+body NOUN B-O
+wall NOUN B-O
+muscle NOUN B-O
+( PUNCT B-O
+arrow NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+adjacent ADJ B-O
+unlabeled VERB B-O
+mitochondria NOUN B-O
+in ADP B-O
+a DET B-O
+different ADJ B-O
+cell NOUN B-O
+type NOUN B-O
+( PUNCT B-O
+arrowheads NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+( PUNCT B-O
+D X B-O
+– PUNCT B-O
+E X B-O
+) PUNCT B-O
+Ultrastructural ADJ B-O
+localization NOUN B-O
+of ADP B-O
+miniSOG PROPN B-AC
+- PUNCT B-O
+labeled VERB B-O
+synaptic ADJ B-LF
+cell NOUN I-LF
+- PUNCT I-LF
+adhesion NOUN I-LF
+molecules NOUN I-LF
+( PUNCT B-O
+SynCAMs PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+cultured VERB B-O
+cortical ADJ B-O
+neurons NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+D X B-O
+) PUNCT B-O
+SynCAM1 PROPN B-O
+fusion NOUN B-O
+reveals VERB B-O
+uniform ADJ B-O
+membrane NOUN B-O
+labeling NOUN B-O
+at ADP B-O
+the DET B-O
+presynaptic ADJ B-O
+apposition NOUN B-O
+( PUNCT B-O
+arrow NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+( PUNCT B-O
+E X B-O
+) PUNCT B-O
+SynCAM2 PROPN B-O
+fusion NOUN B-O
+shows VERB B-O
+postsynaptic ADJ B-O
+membrane NOUN B-O
+labeling NOUN B-O
+( PUNCT B-O
+pointed VERB B-O
+by ADP B-O
+arrow NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Att PROPN B-O
+, PUNCT B-O
+Attacin PROPN B-O
+A PROPN B-O
+; PUNCT B-O
+Dpt PROPN B-O
+, PUNCT B-O
+Diptericin PROPN B-O
+; PUNCT B-O
+Drs NOUN B-O
+, PUNCT B-O
+Drosomycin PROPN B-O
+; PUNCT B-O
+IMD PROPN B-O
+/ SYM B-O
+NFkB PROPN B-AC
+, PUNCT B-O
+immune ADJ B-O
+deficiency NOUN B-O
+/ SYM B-O
+nuclear ADJ B-LF
+factor NOUN I-LF
+kappa NOUN I-LF
+B PROPN I-LF
+; PUNCT B-O
+qRT PROPN B-AC
+, PUNCT B-O
+quantitative ADJ B-LF
+real ADJ I-LF
+- PUNCT I-LF
+time NOUN I-LF
+PCR NOUN I-LF
+; PUNCT B-O
+-PCRRNAi PROPN B-AC
+, PUNCT B-O
+RNA NOUN B-LF
+interference NOUN I-LF
+. PUNCT B-O
+
+We PRON B-O
+sought VERB B-O
+to ADP B-O
+develop VERB B-O
+and CCONJ B-O
+validate VERB B-O
+an DET B-O
+outcomes NOUN B-O
+model NOUN B-O
+for ADP B-O
+the DET B-O
+development NOUN B-O
+of ADP B-O
+diabetes NOUN B-O
+and CCONJ B-O
+related ADJ B-O
+complications NOUN B-O
+derived VERB B-O
+from ADP B-O
+Chinese ADJ B-O
+( PUNCT B-O
+East ADJ B-O
+Asian ADJ B-O
+) PUNCT B-O
+populations NOUN B-O
+and CCONJ B-O
+compare VERB B-O
+this DET B-O
+new ADJ B-O
+Chinese ADJ B-LF
+Hong PROPN I-LF
+Kong PROPN I-LF
+Integrated PROPN I-LF
+Modeling PROPN I-LF
+and CCONJ I-LF
+Evaluation PROPN I-LF
+( PUNCT B-O
+CHIME PROPN B-AC
+) PUNCT B-O
+model NOUN B-O
+to ADP B-O
+the DET B-O
+existing VERB B-O
+UKPDS PROPN B-AC
+and CCONJ B-O
+-OM2RECODe PROPN B-AC
+models NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+A X B-O
+) PUNCT B-O
+Immunoblot NOUN B-O
+analysis NOUN B-O
+of ADP B-O
+acetylation NOUN B-O
+levels NOUN B-O
+of ADP B-O
+7 NUM B-O
+lysine NOUN B-O
+residues NOUN B-O
+on ADP B-O
+histone NOUN B-O
+H3 NOUN B-O
+protein NOUN B-O
+in ADP B-O
+the DET B-O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+( PUNCT B-O
+WT PROPN B-AC
+) PUNCT B-O
+strain NOUN B-O
+and CCONJ B-O
+the DET B-O
+mutants NOUN B-O
+ΔHdac1 NOUN B-O
+and CCONJ B-O
+ΔHat1 NOUN B-O
+. PUNCT B-O
+
+Different ADJ B-O
+subtypes NOUN B-O
+of ADP B-O
+T NOUN B-LF
+helper NOUN I-LF
+( PUNCT B-O
+Th PROPN B-AC
+) PUNCT B-O
+cells NOUN B-O
+are AUX B-O
+activated VERB B-O
+in ADP B-O
+different ADJ B-O
+types NOUN B-O
+of ADP B-O
+chronic ADJ B-O
+intestinal ADJ B-O
+inflammation NOUN B-O
+. PUNCT B-O
+
+For ADP B-O
+encoding NOUN B-O
+and CCONJ B-O
+consolidation NOUN B-O
+, PUNCT B-O
+we PRON B-O
+compared VERB B-O
+30 NUM B-O
+min NOUN B-O
+and CCONJ B-O
+5 NUM B-O
+h NOUN B-O
+after ADP B-O
+the DET B-O
+watermaze NOUN B-LF
+encoding NOUN B-O
+session NOUN B-O
+animals NOUN B-O
+that PRON B-O
+experienced VERB B-O
+the DET B-O
+watermaze NOUN B-LF
+( PUNCT B-O
+WM PROPN B-AC
+) PUNCT B-O
+directly ADV B-O
+with ADP B-O
+animals NOUN B-O
+that PRON B-O
+had AUX B-O
+not PART B-O
+experienced VERB B-O
+the DET B-O
+watermaze NOUN B-LF
+( PUNCT B-O
+NoWM PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Thus ADV B-O
+, PUNCT B-O
+positive ADJ B-O
+values NOUN B-O
+on ADP B-O
+the DET B-O
+y NOUN B-O
+- NOUN B-O
+axis NOUN B-O
+show VERB B-O
+that PRON B-O
+animals NOUN B-O
+consolidating VERB B-O
+a DET B-O
+memory NOUN B-O
+( PUNCT B-O
+WM PROPN B-AC
+) PUNCT B-O
+show VERB B-O
+higher ADJ B-O
+gene NOUN B-O
+expression NOUN B-O
+than ADP B-O
+animals NOUN B-O
+that PRON B-O
+are AUX B-O
+not PART B-O
+consolidating VERB B-O
+a DET B-O
+memory NOUN B-O
+( PUNCT B-O
+NoWM PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+independent ADJ B-O
+of ADP B-O
+what PRON B-O
+they PRON B-O
+are AUX B-O
+doing VERB B-O
+at ADP B-O
+the DET B-O
+moment NOUN B-O
+( PUNCT B-O
+sleep NOUN B-O
+/ SYM B-O
+N+SD PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Additionally ADV B-O
+, PUNCT B-O
+to PART B-O
+investigate VERB B-O
+the DET B-O
+differences NOUN B-O
+between ADP B-O
+sleep NOUN B-O
+and CCONJ B-O
+N PROPN B-AC
+animals NOUN B-O
+at ADP B-O
+retrieval NOUN B-O
+, PUNCT B-O
+we PRON B-O
+calculated VERB B-O
+percentage NOUN B-O
+change NOUN B-O
+( PUNCT B-O
+sleep NOUN B-O
+> SYM B-O
++SDN PROPN B-AC
+) PUNCT B-O
+on ADP B-O
+each DET B-O
+plate NOUN B-O
+and CCONJ B-O
+then ADV B-O
+averaged VERB B-O
+the DET B-O
+data NOUN B-O
+( PUNCT B-O
+see VERB B-O
+S7 PROPN B-O
+Fig PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+AOR PROPN B-AC
+= PUNCT B-O
+Adjusted ADJ B-O
+Adds NOUN B-O
+Ratio NOUN B-O
+, PUNCT B-O
+COR PROPN B-AC
+= PUNCT B-O
+Crude NOUN B-LF
+Odds NOUN I-LF
+Ratio NOUN I-LF
+. PUNCT B-O
+

data/data_test.conll

@@ -0,0 +1,5152 @@
+Abbreviations NOUN B-O
+: PUNCT B-O
+GEMS PROPN B-AC
+, PUNCT B-O
+Global PROPN B-LF
+Enteric PROPN I-LF
+Multicenter PROPN I-LF
+Study PROPN I-LF
+; PUNCT B-O
+VIP PROPN B-AC
+, PUNCT B-O
+ventilated VERB B-LF
+improved ADJ I-LF
+pit NOUN I-LF
+. PUNCT B-O
+
+Fractions NOUN B-O
+from ADP B-O
+FPLC PROPN B-O
+purification NOUN B-O
+were AUX B-O
+treated VERB B-O
+with ADP B-O
+Laemmli PROPN B-O
+buffer NOUN B-O
+[ X B-O
+82 X B-O
+] X B-O
+with ADP B-O
+10 NUM B-O
+mM NOUN B-O
+1,4 NUM B-O
+- PUNCT B-O
+dithiothreitol NOUN B-LF
+( PUNCT B-O
+DTT PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+heated VERB B-O
+for ADP B-O
+5 NUM B-O
+m NOUN B-O
+at ADP B-O
+85 NUM B-O
+° NOUN B-O
+C NOUN B-O
+then ADV B-O
+analyzed VERB B-O
+on ADP B-O
+a DET B-O
+4 NUM B-O
+% NOUN B-O
+to PART B-O
+15 NUM B-O
+% NOUN B-O
+discontinuous ADJ B-O
+SDS PROPN B-AC
+gel NOUN B-O
+with ADP B-O
+a DET B-O
+6 NUM B-O
+% NOUN B-O
+stacking NOUN B-O
+gel NOUN B-O
+run VERB B-O
+at ADP B-O
+ambient ADJ B-O
+temperature NOUN B-O
+at ADP B-O
+a DET B-O
+constant ADJ B-O
+100 NUM B-O
+V. NOUN B-O
+Two NUM B-O
+epithelial ADJ B-O
+cytokines NOUN B-O
+other ADJ B-O
+than ADP B-O
+IL33 NOUN B-O
+, PUNCT B-O
+IL25 NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+thymic ADJ B-LF
+stromal ADJ I-LF
+lymphopoietin NOUN I-LF
+( PUNCT B-O
+TSLP PROPN B-AC
+) PUNCT B-O
+are AUX B-O
+known VERB B-O
+to PART B-O
+activate VERB B-O
+ILC2 PROPN B-AC
+in ADP B-O
+the DET B-O
+lung NOUN B-O
+[ PUNCT B-O
+22,24 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+We PRON B-O
+developed VERB B-O
+a DET B-O
+variant NOUN B-O
+of ADP B-O
+gene NOUN B-LF
+set NOUN I-LF
+enrichment NOUN I-LF
+analysis NOUN I-LF
+( PUNCT B-O
+GSEA PROPN B-AC
+) PUNCT B-O
+to PART B-O
+determine VERB B-O
+whether SCONJ B-O
+a DET B-O
+genetic ADJ B-O
+pathway NOUN B-O
+shows VERB B-O
+evidence NOUN B-O
+for ADP B-O
+age NOUN B-O
+regulation NOUN B-O
+[ PUNCT B-O
+23 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Red NOUN B-O
+represents VERB B-O
+samples NOUN B-O
+having VERB B-O
+the DET B-O
+normalized VERB B-O
+pY232 PROPN B-AC
+and/or CCONJ B-O
+pY291 NOUN B-O
+values NOUN B-O
+in ADP B-O
+cancer NOUN B-O
+tissues NOUN B-O
+≥ PUNCT B-O
+1.1 NUM B-O
+folds NOUN B-O
+of ADP B-O
+normal ADJ B-O
+tissues NOUN B-O
+( PUNCT B-O
+of ADP B-O
+which PRON B-O
+enhanced VERB B-O
+pY232 PROPN B-AC
+and/or CCONJ B-O
+pY291 NOUN B-O
+level NOUN B-O
+may AUX B-O
+be AUX B-O
+indicative ADJ B-O
+of ADP B-O
+dominant ADJ B-O
+survival NOUN B-O
+mode NOUN B-O
+of ADP B-O
+Fas PROPN B-O
+signaling NOUN B-O
+) PUNCT B-O
+; PUNCT B-O
+blue NOUN B-O
+represents VERB B-O
+samples NOUN B-O
+having VERB B-O
+both CCONJ B-O
+normalized VERB B-O
+pY232 PROPN B-AC
+and CCONJ B-O
+pY291 NOUN B-O
+values NOUN B-O
+< ADP B-O
+1.1 NUM B-O
+( PUNCT B-O
+of ADP B-O
+which PRON B-O
+pY232 PROPN B-AC
+and CCONJ B-O
+pY291 NOUN B-O
+levels NOUN B-O
+less ADJ B-O
+than ADP B-O
+or CCONJ B-O
+equal ADJ B-O
+to ADP B-O
+normal ADJ B-O
+may AUX B-O
+be AUX B-O
+indicative ADJ B-O
+of ADP B-O
+the DET B-O
+apoptosis NOUN B-O
+- NOUN B-O
+ready ADJ B-O
+mode NOUN B-O
+of ADP B-O
+Fas PROPN B-O
+signaling NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+( PUNCT B-O
+D X B-O
+) PUNCT B-O
+Lysates NOUN B-O
+of ADP B-O
+rectal ADJ B-O
+cancer NOUN B-O
+tissues NOUN B-O
+before ADP B-O
+and CCONJ B-O
+after ADP B-O
+radiotherapy NOUN B-LF
+( PUNCT B-O
+RT PROPN B-AC
+) PUNCT B-O
+from ADP B-O
+each PRON B-O
+of ADP B-O
+the DET B-O
+nine NUM B-O
+patients NOUN B-O
+were AUX B-O
+subjected VERB B-O
+to ADP B-O
+SDS PROPN B-O
+- NOUN B-O
+PAGE PROPN B-O
+and CCONJ B-O
+immunoblotting NOUN B-O
+with ADP B-O
+antibodies NOUN B-O
+against ADP B-O
+pY232 PROPN B-AC
+, PUNCT B-O
+pY291 NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+C NOUN B-O
+- NOUN B-O
+terminal ADJ B-O
+( PUNCT B-O
+C NOUN B-O
+- NOUN B-O
+ter NOUN B-O
+) PUNCT B-O
+of ADP B-O
+Fas PROPN B-O
+. PUNCT B-O
+
+Relative ADJ B-LF
+risks NOUN I-LF
+( PUNCT B-O
+RRs PROPN B-AC
+) PUNCT B-O
+with ADP B-O
+95 NUM B-O
+% NOUN B-O
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+geij NOUN B-O
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+the DET B-O
+G×E PROPN B-AC
+effect NOUN B-O
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+δ(j)m NOUN B-O
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+εijm NOUN B-O
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+N NOUN B-O
+( PUNCT B-O
+0 NUM B-O
+, PUNCT B-O
+σε2 NUM B-O
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+KO PROPN B-AC
+, PUNCT B-O
+knockout NOUN B-LF
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+PSD PROPN B-AC
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+postsynaptic ADJ B-LF
+density NOUN I-LF
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+Small ADJ B-O
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+SW480 NUM B-O
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+reads NOUN B-O
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+- PUNCT B-O
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+intraclass NOUN B-LF
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+( PUNCT B-O
+ICC PROPN B-AC
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+R PROPN B-O
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+( PUNCT B-O
+Version PROPN B-O
+1.1.456 NUM B-O
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+RStudio PROPN B-O
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+2 NUM B-O
+- PUNCT B-O
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+- PUNCT B-O
+effects NOUN B-O
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+qualitative ADJ B-O
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+[ PUNCT B-O
+42 NUM B-O
+] PUNCT B-O
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+
+The DET B-O
+signaling NOUN B-O
+molecule NOUN B-O
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+by ADP B-O
+the DET B-O
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+arginine NOUN B-LF
+vasopressin NOUN I-LF
+( PUNCT B-O
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+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
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+( PUNCT B-O
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+- PUNCT B-O
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+- PUNCT B-O
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+PDF PROPN B-AC
+- PUNCT B-O
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+LNVs PROPN B-AC
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+- PUNCT B-O
+advance NOUN B-O
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+LD PROPN B-AC
+, PUNCT B-O
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+- PUNCT B-O
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+locomotor ADJ B-O
+rhythms NOUN B-O
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+DD PROPN B-AC
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+In ADP B-O
+order NOUN B-O
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+( PUNCT B-O
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+LND PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+dorsal ADJ B-LF
+neuron NOUN I-LF
+( PUNCT B-O
+DN)1 PROPN B-AC
+, PUNCT B-O
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+flies NOUN B-O
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+membrane NOUN B-O
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+- PUNCT B-O
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+. PUNCT B-O
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+PDP1 PROPN B-AC
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+oscillating VERB B-O
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+8 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
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+Mosquitoes NOUN B-O
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+, PUNCT B-O
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+h NOUN B-O
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+the DET B-O
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+( PUNCT B-O
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+Compared VERB B-O
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+Lymphocytes NOUN B-O
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+These DET B-O
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+PM2.5 PROPN B-AC
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+( PUNCT B-O
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+2.5 NUM B-O
+μm NOUN B-O
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+The DET B-O
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+3 NUM I-LF
+( PUNCT B-O
+iGb3 PROPN B-AC
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+( PUNCT B-O
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+cell NOUN B-O
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+self NOUN B-O
+- PUNCT B-O
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+humans NOUN B-O
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+Other ADJ B-O
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+16,17 X B-O
+] X B-O
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+( PUNCT B-O
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+( PUNCT B-O
+627/1,271 NUM B-O
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+( PUNCT B-O
+1,026/1,271 NUM B-O
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+( PUNCT B-O
+427/1,271 NUM B-O
+) PUNCT B-O
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+- ADJ B-O
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+rates NOUN B-O
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+risk NOUN B-O
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+( PUNCT B-O
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+- ADJ B-O
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+This DET B-O
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+( PUNCT B-O
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+( PUNCT B-O
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+, PUNCT B-O
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+( PUNCT B-O
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+( PUNCT B-O
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+< NUM B-O
+90th NUM B-O
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+Most ADV B-O
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+NP PROPN B-AC
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+The DET B-O
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+( PUNCT B-O
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+miR-148a NOUN B-O
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+25 NUM B-O
+- ADJ B-O
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+( PUNCT B-O
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+- ADJ B-O
+coding ADJ B-O
+RNA NOUN B-O
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+the DET B-O
+expression NOUN B-O
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+4 NUM B-O
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+( PUNCT B-O
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+To PART B-O
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+, PUNCT B-O
+negative ADJ B-O
+- PUNCT B-O
+stranded ADJ B-O
+RNA NOUN B-O
+virus NOUN B-O
+. PUNCT B-O
+
+Legend NOUN B-O
+: PUNCT B-O
+HCV PROPN B-AC
+: PUNCT B-O
+Chronic ADJ B-O
+hepatitis NOUN B-O
+C NOUN B-O
+; PUNCT B-O
+DAA PROPN B-AC
+: PUNCT B-O
+Direct ADV B-LF
+- PUNCT I-LF
+acting VERB I-LF
+antivirals NOUN I-LF
+; PUNCT B-O
+N NOUN B-O
+: PUNCT B-O
+Sample NOUN B-O
+size NOUN B-O
+; PUNCT B-O
+comorbidities NOUN B-O
+: PUNCT B-O
+Comorbidity NOUN B-O
+; PUNCT B-O
+comedications NOUN B-O
+: PUNCT B-O
+Comedication NOUN B-O
+. PUNCT B-O
+
+Time NOUN B-O
+to ADP B-O
+ART PROPN B-AC
+initiation NOUN B-O
+was AUX B-O
+estimated VERB B-O
+using VERB B-O
+cumulative ADJ B-LF
+incidence NOUN I-LF
+functions NOUN I-LF
+( PUNCT B-O
+CIFs PROPN B-AC
+): PUNCT B-O
+mortality NOUN B-O
+and CCONJ B-O
+LTFU PROPN B-AC
+were AUX B-O
+considered VERB B-O
+competing VERB B-O
+events NOUN B-O
+to ADP B-O
+ART PROPN B-AC
+initiation NOUN B-O
+[ PUNCT B-O
+9 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+while SCONJ B-O
+those PRON B-O
+transferred VERB B-O
+out ADV B-O
+were AUX B-O
+right ADV B-O
+- PUNCT B-O
+censored VERB B-O
+, PUNCT B-O
+with ADP B-O
+the DET B-O
+assumption NOUN B-O
+that SCONJ B-O
+they PRON B-O
+remained VERB B-O
+in ADP B-O
+HIV PROPN B-O
+care NOUN B-O
+and CCONJ B-O
+had VERB B-O
+similar ADJ B-O
+outcomes NOUN B-O
+as ADP B-O
+patients NOUN B-O
+still ADV B-O
+in ADP B-O
+observation NOUN B-O
+. PUNCT B-O
+
+FISH PROPN B-AC
+, PUNCT B-O
+fluorescence NOUN B-LF
+in ADP I-LF
+situ NOUN I-LF
+hybridization NOUN I-LF
+. PUNCT B-O
+
+We PRON B-O
+included VERB B-O
+those PRON B-O
+with ADP B-O
+follow VERB B-O
+- PUNCT B-O
+up ADP B-O
+visits NOUN B-O
+and CCONJ B-O
+pulmonary ADJ B-LF
+function NOUN I-LF
+tests NOUN I-LF
+( PUNCT B-O
+PFTs PROPN B-AC
+) PUNCT B-O
+available ADJ B-O
+after ADP B-O
+hospitalization NOUN B-O
+. PUNCT B-O
+
+WT PROPN B-O
+, PUNCT B-O
+wild ADJ B-O
+type NOUN B-O
+; PUNCT B-O
+TG PROPN B-AC
+, PUNCT B-O
+transgenic ADJ B-O
+; PUNCT B-O
+TSA PROPN B-AC
+, PUNCT B-O
+total ADJ B-LF
+salvianolic ADJ I-LF
+acid NOUN I-LF
+; PUNCT B-O
+n NOUN B-O
+= SYM B-O
+20 NUM B-O
+, PUNCT B-O
+error NOUN B-O
+bars NOUN B-O
+represent VERB B-O
+SEM NOUN B-O
+. PUNCT B-O
+
+* NOUN B-O
+p<0.05 NUM B-O
+, PUNCT B-O
+* NOUN B-O
+* NOUN B-O
+p<0.01 NUM B-O
+versus ADP B-O
+WT PROPN B-O
+control NOUN B-O
+group NOUN B-O
+; PUNCT B-O
+# SYM B-O
+p<0.05 NUM B-O
+, PUNCT B-O
+# SYM B-O
+# SYM B-O
+p<0.01 NUM B-O
+versus ADP B-O
+vehicle NOUN B-O
+- PUNCT B-O
+treated VERB B-O
+APPswe PROPN B-O
+/ SYM B-O
+PS1dE9 PROPN B-O
+transgenic ADJ B-O
+group NOUN B-O
+. PUNCT B-O
+
+M PROPN B-O
+, PUNCT B-O
+mirror NOUN B-O
+; PUNCT B-O
+P NOUN B-O
+, PUNCT B-O
+pinhole NOUN B-O
+; PUNCT B-O
+λ/2 NUM B-O
+, PUNCT B-O
+λ/2 NUM B-O
+plate NOUN B-O
+; PUNCT B-O
+PBS PROPN B-AC
+, PUNCT B-O
+polarizing VERB B-LF
+beam NOUN I-LF
+splitter NOUN I-LF
+; PUNCT B-O
+EOM PROPN B-O
+, PUNCT B-O
+electro ADJ B-O
+optical ADJ B-O
+modulator NOUN B-O
+; PUNCT B-O
+S NOUN B-O
+, PUNCT B-O
+shutter NOUN B-O
+; PUNCT B-O
+F NOUN B-O
+, PUNCT B-O
+filter NOUN B-O
+; PUNCT B-O
+Pol PROPN B-O
+, PUNCT B-O
+polarizer NOUN B-O
+; PUNCT B-O
+DC NOUN B-O
+, PUNCT B-O
+dichroic ADJ B-O
+mirror NOUN B-O
+. PUNCT B-O
+
+In ADP B-O
+the DET B-O
+third ADJ B-O
+group NOUN B-O
+, PUNCT B-O
+the DET B-O
+variables NOUN B-O
+related VERB B-O
+to ADP B-O
+resuming VERB B-O
+dialysis NOUN B-O
+were AUX B-O
+: PUNCT B-O
+Charlson PROPN B-O
+comorbidity NOUN B-O
+index NOUN B-O
+[ PUNCT B-O
+18 NUM B-O
+] PUNCT B-O
+; PUNCT B-O
+dialysis NOUN B-O
+modality NOUN B-O
+and CCONJ B-O
+access NOUN B-O
+, PUNCT B-O
+such ADJ B-O
+as ADP B-O
+arterio ADJ B-O
+- PUNCT B-O
+venous ADJ B-O
+( PUNCT B-O
+AV PROPN B-AC
+) PUNCT B-O
+fistula NOUN B-O
+as ADP B-O
+access NOUN B-O
+for ADP B-O
+hemodialysis NOUN B-O
+, PUNCT B-O
+venous ADJ B-O
+catheters NOUN B-O
+, PUNCT B-O
+or CCONJ B-O
+peritoneal ADJ B-O
+catheters NOUN B-O
+for ADP B-O
+peritoneal ADJ B-O
+dialysis NOUN B-O
+; PUNCT B-O
+and CCONJ B-O
+biochemical ADJ B-O
+parameters NOUN B-O
+such ADJ B-O
+as ADP B-O
+creatinine NOUN B-O
+, PUNCT B-O
+hemoglobin NOUN B-O
+, PUNCT B-O
+urea NOUN B-O
+, PUNCT B-O
+potassium NOUN B-O
+, PUNCT B-O
+ionic ADJ B-O
+calcium NOUN B-O
+, PUNCT B-O
+phosphorus NOUN B-O
+, PUNCT B-O
+parathormone NOUN B-LF
+( PUNCT B-O
+PTH PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+serum NOUN B-O
+albumin NOUN B-O
+and CCONJ B-O
+C NOUN B-O
+- PUNCT B-O
+reactive ADJ B-O
+protein NOUN B-O
+. PUNCT B-O
+
+HPD PROPN B-AC
+, PUNCT B-O
+human ADJ B-LF
+population NOUN I-LF
+density NOUN I-LF
+. PUNCT B-O
+
+PD PROPN B-AC
+; PUNCT B-O
+the DET B-O
+ERK PROPN B-O
+inhibitor NOUN B-O
+PD98059 PROPN B-LF
+. PUNCT B-O
+
+β PUNCT B-O
+- PUNCT B-O
+Actin PROPN B-O
+served VERB B-O
+as ADP B-O
+an DET B-O
+input NOUN B-O
+control NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+G NOUN B-O
+) PUNCT B-O
+Levels NOUN B-O
+of ADP B-O
+inflammatory ADJ B-O
+response NOUN B-O
+markers NOUN B-O
+( PUNCT B-O
+NF NOUN B-O
+- PUNCT B-O
+κB NOUN B-O
+p65 NOUN B-O
+activity NOUN B-O
+and CCONJ B-O
+TNFα PROPN B-O
+and CCONJ B-O
+IL-8 PROPN B-AC
+production NOUN B-O
+, PUNCT B-O
+by ADP B-O
+ELISA PROPN B-O
+) PUNCT B-O
+in ADP B-O
+control NOUN B-O
+medium NOUN B-O
+- PUNCT B-O
+treated VERB B-O
+or CCONJ B-O
+CSE PROPN B-AC
+- PUNCT B-O
+exposed VERB B-O
+H292 PROPN B-O
+cells NOUN B-O
+, PUNCT B-O
+pretreated VERB B-O
+with ADP B-O
+either CCONJ B-O
+Csn-B PROPN B-AC
+( PUNCT B-O
+10 NUM B-O
+μM NOUN B-O
+) PUNCT B-O
+or CCONJ B-O
+Veh PROPN B-AC
+. PUNCT B-O
+
+( PUNCT B-O
+left ADJ B-O
+panel NOUN B-O
+) PUNCT B-O
+Spectrophotometric ADJ B-O
+reading NOUN B-O
+value NOUN B-O
+( PUNCT B-O
+A450 NOUN B-O
+) PUNCT B-O
+represents VERB B-O
+NF NOUN B-O
+- PUNCT B-O
+κB NOUN B-O
+p65 NOUN B-O
+activity NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+middle ADJ B-O
+and CCONJ B-O
+right ADJ B-O
+panels NOUN B-O
+) PUNCT B-O
+The DET B-O
+levels NOUN B-O
+of ADP B-O
+cytokine NOUN B-O
+and CCONJ B-O
+chemokine NOUN B-O
+are AUX B-O
+shown VERB B-O
+as ADP B-O
+protein NOUN B-O
+concentrations NOUN B-O
+( PUNCT B-O
+pg NOUN B-O
+) PUNCT B-O
+in ADP B-O
+ml NOUN B-O
+of ADP B-O
+cell NOUN B-O
+culture NOUN B-O
+medium NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+EP3 NOUN B-O
+receptor NOUN B-O
+as ADP B-O
+a DET B-O
+PGE2 PROPN B-AC
+receptor NOUN B-O
+, PUNCT B-O
+same ADJ B-O
+as ADP B-O
+the DET B-O
+other ADJ B-O
+types NOUN B-O
+of ADP B-O
+EP PROPN B-O
+receptor NOUN B-O
+( PUNCT B-O
+EP1 NOUN B-O
+- PUNCT B-O
+2 NUM B-O
+and CCONJ B-O
+EP4 PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+is AUX B-O
+a DET B-O
+G PROPN B-LF
+- PUNCT I-LF
+protein NOUN I-LF
+- PUNCT I-LF
+coupled VERB I-LF
+receptor NOUN I-LF
+( PUNCT B-O
+GPCR PROPN B-AC
+) PUNCT B-O
+[ X B-O
+23 NUM B-O
+] PUNCT B-O
+and CCONJ B-O
+specifically ADV B-O
+contributes VERB B-O
+to ADP B-O
+the DET B-O
+cough NOUN B-O
+through ADP B-O
+activating VERB B-O
+airway NOUN B-O
+sensory ADJ B-O
+nerves NOUN B-O
+[ X B-O
+24 NUM B-O
+, PUNCT B-O
+25 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+G6PD PROPN B-AC
+, PUNCT B-O
+glucose-6 NOUN B-LF
+- PUNCT I-LF
+phosphate NOUN I-LF
+dehydrogenase NOUN I-LF
+. PUNCT B-O
+
+Partial ADJ B-LF
+least ADJ I-LF
+squares NOUN I-LF
+regression NOUN I-LF
+( PUNCT B-O
+PLSR PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+a DET B-O
+technique NOUN B-O
+previously ADV B-O
+shown VERB B-O
+to ADP B-O
+be AUX B-O
+useful ADJ B-O
+for ADP B-O
+the DET B-O
+creation NOUN B-O
+of ADP B-O
+signal NOUN B-O
+– PUNCT B-O
+response NOUN B-O
+models NOUN B-O
+based VERB B-O
+on ADP B-O
+highly ADV B-O
+dimensional ADJ B-O
+datasets NOUN B-O
+, PUNCT B-O
+was AUX B-O
+used VERB B-O
+to ADP B-O
+correlate VERB B-O
+phosphorylation NOUN B-O
+events NOUN B-O
+to ADP B-O
+both CCONJ B-O
+migration NOUN B-O
+and CCONJ B-O
+proliferation NOUN B-O
+[ PUNCT B-O
+10 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Copper NOUN B-LF
+( PUNCT B-O
+Cu PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+zinc NOUN B-LF
+( PUNCT B-O
+Zn PROPN B-AC
+) PUNCT B-O
+are AUX B-O
+essential ADJ B-O
+nutritional ADJ B-O
+metals NOUN B-O
+required VERB B-O
+for ADP B-O
+the DET B-O
+function NOUN B-O
+of ADP B-O
+numerous ADJ B-O
+enzymatic ADJ B-O
+molecules NOUN B-O
+active ADJ B-O
+in ADP B-O
+human ADJ B-O
+cell NOUN B-O
+metabolic ADJ B-O
+pathways NOUN B-O
+. PUNCT B-O
+
+RNase NOUN B-O
+T NOUN B-O
+showed VERB B-O
+in ADP B-O
+in ADP B-O
+vitro ADJ B-O
+experiments NOUN B-O
+that SCONJ B-O
+it PRON B-O
+can AUX B-O
+serve VERB B-O
+as ADP B-O
+a DET B-O
+downstream ADJ B-O
+exonuclease NOUN B-O
+of ADP B-O
+Endonuclease NOUN B-LF
+V NOUN I-LF
+( PUNCT B-O
+alternative ADJ B-LF
+EndoV)–mediated PROPN B-AC
+base NOUN I-LF
+excision NOUN I-LF
+repair NOUN I-LF
+( PUNCT B-O
+AER PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+33 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Interestingly ADV B-O
+, PUNCT B-O
+incubation NOUN B-O
+of ADP B-O
+parasites NOUN B-O
+in ADP B-O
+the DET B-O
+presence NOUN B-O
+of ADP B-O
+0.5 NUM B-O
+μM NOUN B-O
+Cytochalasin NOUN B-LF
+D PROPN I-LF
+( PUNCT B-O
+CD PROPN B-AC
+; PUNCT B-O
+a DET B-O
+drug NOUN B-O
+used VERB B-O
+to PART B-O
+disrupt VERB B-O
+F NOUN B-O
+- ADJ B-O
+actin NOUN B-O
+) PUNCT B-O
+did AUX B-O
+not PART B-O
+result VERB B-O
+in ADP B-O
+significant ADJ B-O
+reduction NOUN B-O
+of ADP B-O
+bead NOUN B-O
+translocation NOUN B-O
+( PUNCT B-O
+Fig NOUN B-O
+1 NUM B-O
+G NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+confirming VERB B-O
+that SCONJ B-O
+retrograde ADJ B-O
+membrane NOUN B-O
+flow NOUN B-O
+can AUX B-O
+occur VERB B-O
+in ADP B-O
+the DET B-O
+absence NOUN B-O
+of ADP B-O
+a DET B-O
+functional ADJ B-O
+acto NOUN B-O
+- ADJ B-O
+myosin NOUN B-O
+system NOUN B-O
+, PUNCT B-O
+as SCONJ B-O
+reported VERB B-O
+previously ADV B-O
+[ X B-O
+5 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Focal ADJ B-O
+increases NOUN B-O
+in ADP B-O
+fMRI PROPN B-AC
+- PUNCT B-O
+activity NOUN B-O
+were AUX B-O
+observed VERB B-O
+in ADP B-O
+area NOUN B-O
+AIP PROPN B-AC
+, PUNCT B-O
+consisting VERB B-O
+of ADP B-O
+both DET B-O
+aAIP PROPN B-AC
+and CCONJ B-O
+pAIP PROPN B-AC
+( PUNCT B-O
+Fig NOUN B-O
+. PUNCT B-O
+
+2A NUM B-O
+, PUNCT B-O
+left ADJ B-O
+column NOUN B-O
+, PUNCT B-O
+first ADJ B-O
+and CCONJ B-O
+second ADJ B-O
+row NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+in ADP B-O
+the DET B-O
+anterior ADJ B-O
+lateral ADJ B-O
+bank NOUN B-O
+of ADP B-O
+the DET B-O
+IPS PROPN B-AC
+. PUNCT B-O
+
+Furthermore ADV B-O
+, PUNCT B-O
+aAIP PROPN B-AC
+- PUNCT B-O
+EM PROPN B-AC
+elicited VERB B-O
+significant ADJ B-O
+fMRI PROPN B-AC
+activations NOUN B-O
+in ADP B-O
+the DET B-O
+medial ADJ B-O
+bank NOUN B-O
+of ADP B-O
+the DET B-O
+IPS PROPN B-AC
+( PUNCT B-O
+area NOUN B-O
+MIP PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+in ADP B-O
+area NOUN B-O
+PFG PROPN B-AC
+in ADP B-O
+the DET B-O
+rostral ADJ B-O
+portion NOUN B-O
+of ADP B-O
+the DET B-O
+inferior ADJ B-O
+parietal ADJ B-O
+lobule NOUN B-O
+, PUNCT B-O
+in ADP B-O
+the DET B-O
+most ADV B-O
+anterior ADJ B-O
+sector NOUN B-O
+of ADP B-O
+somatosensory ADJ B-O
+area NOUN B-O
+S2 PROPN B-O
+and CCONJ B-O
+in ADP B-O
+ventral ADJ B-LF
+premotor ADJ I-LF
+cortex NOUN I-LF
+( PUNCT B-O
+PMv PROPN B-AC
+, PUNCT B-O
+or CCONJ B-O
+area NOUN B-O
+F5 NUM B-O
+; PUNCT B-O
+Fig NOUN B-O
+. PUNCT B-O
+
+2A NUM B-O
+, PUNCT B-O
+left ADJ B-O
+column NOUN B-O
+, PUNCT B-O
+rows NOUN B-O
+2–5 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Here ADV B-O
+, PUNCT B-O
+the DET B-O
+high ADJ B-O
+level NOUN B-O
+of ADP B-O
+HR PROPN B-AC
+is AUX B-O
+due ADJ B-O
+to ADP B-O
+the DET B-O
+programmed VERB B-O
+formation NOUN B-O
+of ADP B-O
+a DET B-O
+large ADJ B-O
+number NOUN B-O
+of ADP B-O
+DNA NOUN B-O
+double ADJ B-LF
+- PUNCT I-LF
+strand NOUN I-LF
+breaks NOUN I-LF
+( PUNCT B-O
+DSBs PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+4 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Natural ADJ B-LF
+killer NOUN I-LF
+T PROPN I-LF
+( PUNCT B-O
+NKT PROPN B-AC
+) PUNCT B-O
+cell NOUN B-O
+development NOUN B-O
+depends VERB B-O
+on ADP B-O
+recognition NOUN B-O
+of ADP B-O
+self NOUN B-O
+- PUNCT B-O
+glycolipids NOUN B-O
+via ADP B-O
+their PRON B-O
+semi ADJ B-O
+- PUNCT B-O
+invariant ADJ B-O
+Vα14i NOUN B-O
+- PUNCT B-O
+TCR PROPN B-O
+. PUNCT B-O
+
+However ADV B-O
+, PUNCT B-O
+to PART B-O
+what DET B-O
+extent NOUN B-O
+TCR PROPN B-O
+- PUNCT B-O
+mediated VERB B-O
+signals NOUN B-O
+determine VERB B-O
+identity NOUN B-O
+and CCONJ B-O
+function NOUN B-O
+of ADP B-O
+mature ADJ B-O
+NKT PROPN B-AC
+cells NOUN B-O
+remains AUX B-O
+incompletely ADV B-O
+understood VERB B-O
+. PUNCT B-O
+
+Inhalation NOUN B-O
+injury NOUN B-O
+predisposes VERB B-O
+these DET B-O
+patients NOUN B-O
+to ADP B-O
+respiratory ADJ B-O
+failure NOUN B-O
+, PUNCT B-O
+acute ADJ B-LF
+respiratory ADJ I-LF
+distress NOUN I-LF
+syndrome NOUN I-LF
+( PUNCT B-O
+ARDS PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+pneumonia NOUN B-O
+. PUNCT B-O
+
+In ADP B-O
+support NOUN B-O
+of ADP B-O
+this DET B-O
+idea NOUN B-O
+we PRON B-O
+found VERB B-O
+that SCONJ B-O
+a DET B-O
+bacterially ADV B-O
+expressed VERB B-O
+p180 NOUN B-O
+lysine NOUN B-O
+- PUNCT B-O
+rich ADJ B-O
+region NOUN B-O
+, PUNCT B-O
+fused VERB B-O
+to ADP B-O
+glutathione NOUN B-LF
+s NOUN I-LF
+- PUNCT I-LF
+transferase NOUN I-LF
+( PUNCT B-O
+GST PROPN B-AC
+- PUNCT B-O
+p180 NOUN B-O
+- PUNCT B-O
+Lys PROPN B-O
+; PUNCT B-O
+Figure PROPN B-O
+7A NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+could AUX B-O
+form VERB B-O
+a DET B-O
+complex NOUN B-O
+with ADP B-O
+a DET B-O
+32P NOUN B-O
+- PUNCT B-O
+labeled VERB B-O
+RNA NOUN B-O
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+from ADP B-O
+the DET B-O
+human ADJ B-O
+insulin NOUN B-O
+SSCR PROPN B-AC
+( PUNCT B-O
+Figure PROPN B-O
+7B NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+contrast NOUN B-O
+, PUNCT B-O
+no DET B-O
+complex NOUN B-O
+was AUX B-O
+formed VERB B-O
+between ADP B-O
+this DET B-O
+RNA NOUN B-O
+and CCONJ B-O
+a DET B-O
+control NOUN B-O
+protein NOUN B-O
+, PUNCT B-O
+GST PROPN B-AC
+- PUNCT B-O
+Ran PROPN B-O
+( PUNCT B-O
+Figure PROPN B-O
+7A NUM B-O
+– PUNCT B-O
+B NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+By ADP B-O
+varying VERB B-O
+the DET B-O
+amount NOUN B-O
+of ADP B-O
+protein NOUN B-O
+in ADP B-O
+our PRON B-O
+binding VERB B-O
+assay NOUN B-O
+, PUNCT B-O
+we PRON B-O
+estimate VERB B-O
+that SCONJ B-O
+the DET B-O
+GST PROPN B-AC
+- PUNCT B-O
+p180 NOUN B-O
+- PUNCT B-O
+Lys PROPN B-O
+binds VERB B-O
+to ADP B-O
+RNA NOUN B-O
+with ADP B-O
+an DET B-O
+affinity NOUN B-O
+of ADP B-O
+about ADP B-O
+0.8 NUM B-O
+µM. NOUN B-O
+Here ADV B-O
+we PRON B-O
+report VERB B-O
+the DET B-O
+modulation NOUN B-O
+of ADP B-O
+the DET B-O
+structure NOUN B-O
+/ SYM B-O
+function NOUN B-O
+of ADP B-O
+recombinant ADJ B-O
+Ace PROPN B-AC
+by ADP B-O
+small ADJ B-O
+molecule NOUN B-O
+calcium NOUN B-LF
+- PUNCT I-LF
+activated VERB I-LF
+chloride NOUN I-LF
+channel NOUN I-LF
+( PUNCT B-O
+CaCC PROPN B-AC
+) PUNCT B-O
+inhibitors NOUN B-O
+, PUNCT B-O
+namely ADV B-O
+CaCCinh PROPN B-O
+- PUNCT B-O
+A01 PROPN B-O
+, PUNCT B-O
+digallic ADJ B-LF
+acid NOUN I-LF
+( PUNCT B-O
+DGA PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+tannic NOUN B-O
+acid NOUN B-O
+. PUNCT B-O
+
+IMD PROPN B-O
+, PUNCT B-O
+Index PROPN B-O
+of ADP B-O
+Multiple ADJ B-O
+Deprivation NOUN B-O
+, PUNCT B-O
+derived VERB B-O
+from ADP B-O
+the DET B-O
+Lower PROPN B-O
+Super PROPN B-O
+Output PROPN B-O
+Area PROPN B-O
+of ADP B-O
+the DET B-O
+patient NOUN B-O
+’s PART B-O
+home NOUN B-O
+address NOUN B-O
+; PUNCT B-O
+IQR PROPN B-AC
+, PUNCT B-O
+interquartile ADJ B-LF
+range NOUN I-LF
+. PUNCT B-O
+
+Analyzed VERB B-O
+parameter NOUN B-O
+were AUX B-O
+immunoreactive ADJ B-LF
+area NOUN B-O
+( PUNCT B-O
+IR PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+percent NOUN B-O
+of ADP B-O
+the DET B-O
+ROI NOUN B-O
+area NOUN B-O
+and CCONJ B-O
+summarized VERB B-O
+object NOUN B-O
+intensity NOUN B-O
+in ADP B-O
+a.u./mm2 X B-O
+. PUNCT B-O
+
+Bovine ADJ B-LF
+serum NOUN I-LF
+albumin NOUN I-LF
+( PUNCT B-O
+BSA PROPN B-AC
+) PUNCT B-O
+medium NOUN B-O
+, PUNCT B-O
+containing VERB B-O
+no DET B-O
+peptides NOUN B-O
+, PUNCT B-O
+was AUX B-O
+used VERB B-O
+as ADP B-O
+a DET B-O
+negative ADJ B-O
+control NOUN B-O
+. PUNCT B-O
+
+Recently ADV B-O
+, PUNCT B-O
+it PRON B-O
+has AUX B-O
+been AUX B-O
+shown VERB B-O
+that PRON B-O
+PD-L1 PROPN B-AC
+intracytoplasmic ADJ B-O
+tail NOUN B-O
+can AUX B-O
+trigger VERB B-O
+a DET B-O
+signal NOUN B-O
+cascade NOUN B-O
+that PRON B-O
+make VERB B-O
+cancer NOUN B-O
+cells NOUN B-O
+resistant ADJ B-O
+to ADP B-O
+interferon NOUN B-LF
+( PUNCT B-O
+IFN)-mediated PROPN B-AC
+cytotoxicity NOUN B-O
+through ADP B-O
+a DET B-O
+STAT3 NOUN B-O
+/ SYM B-O
+caspase-7 NOUN B-O
+- PUNCT B-O
+dependent ADJ B-O
+pathway NOUN B-O
+[ PUNCT B-O
+16 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Their PRON B-O
+transcripts NOUN B-O
+were AUX B-O
+generally ADV B-O
+classified VERB B-O
+into ADP B-O
+two NUM B-O
+groups NOUN B-O
+including VERB B-O
+long ADJ B-O
+non ADJ B-O
+- ADJ B-O
+coding ADJ B-O
+RNAs NOUN B-O
+( PUNCT B-O
+longer ADJ B-O
+than ADP B-O
+200 NUM B-O
+nt NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+small ADJ B-LF
+RNAs NOUN I-LF
+( PUNCT B-O
+sRNAs PROPN B-AC
+, PUNCT B-O
+shorter ADJ B-O
+than ADP B-O
+200 NUM B-O
+nt NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+underlying VERB B-O
+data NOUN B-O
+can AUX B-O
+be AUX B-O
+found VERB B-O
+in ADP B-O
+S1 PROPN B-O
+Data PROPN B-O
+. PUNCT B-O
+
+; PUNCT B-O
+eFSGM PROPN B-AC
+, PUNCT B-O
+extended ADJ B-LF
+FSGM PROPN I-LF
+FSGM PROPN B-AC
+; PUNCT B-O
+FBA PROPN B-AC
+, PUNCT B-O
+feature NOUN B-LF
+- PUNCT I-LF
+based VERB I-LF
+attention NOUN I-LF
+; PUNCT B-O
+HR PROPN B-AC
+, PUNCT B-O
+hit NOUN B-LF
+rate NOUN I-LF
+; PUNCT B-O
+RT PROPN B-AC
+, PUNCT B-O
+reaction NOUN B-LF
+time NOUN I-LF
+. PUNCT B-O
+
+Results NOUN B-O
+of ADP B-O
+logistic ADJ B-O
+regression NOUN B-O
+models NOUN B-O
+are AUX B-O
+presented VERB B-O
+using VERB B-O
+adjusted ADJ B-LF
+Odds NOUN I-LF
+Ratio PROPN I-LF
+( PUNCT B-O
+aOR PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+95 NUM B-LF
+% NOUN I-LF
+Confidence PROPN I-LF
+Interval NOUN I-LF
+( PUNCT B-O
+95 PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+To PART B-O
+handle VERB B-O
+missing VERB B-O
+data NOUN B-O
+of ADP B-O
+two NUM B-O
+covariates NOUN B-O
+, PUNCT B-O
+multivariate ADJ B-O
+logistic ADJ B-O
+regression NOUN B-O
+models NOUN B-O
+were AUX B-O
+performed VERB B-O
+using VERB B-O
+multiple ADJ B-O
+imputation NOUN B-O
+[ X B-O
+45,46 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+F NOUN B-O
+- PUNCT B-O
+actin NOUN B-O
+induction NOUN B-O
+was AUX B-O
+plotted VERB B-O
+as ADP B-O
+mean NOUN B-O
+± SYM B-O
+standard ADJ B-O
+error NOUN B-O
+of ADP B-O
+the DET B-O
+mean NOUN B-O
+( PUNCT B-O
+SEM PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+n NOUN B-O
+= SYM B-O
+3 NUM B-O
+. PUNCT B-O
+
+* PUNCT B-O
+p NOUN B-O
+≤ PUNCT B-O
+0.05 NUM B-O
+, PUNCT B-O
+* PUNCT B-O
+* PUNCT B-O
+* PUNCT B-O
+p NOUN B-O
+≤ PUNCT B-O
+0.001 NUM B-O
+. PUNCT B-O
+
+( PUNCT B-O
+D X B-O
+) PUNCT B-O
+Time NOUN B-O
+- PUNCT B-O
+lapse NOUN B-O
+total ADJ B-LF
+internal ADJ I-LF
+reflection NOUN I-LF
+fluorescence NOUN I-LF
+microscopy NOUN I-LF
+( PUNCT B-O
+TIRFM PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+speckle NOUN B-O
+mCherry NOUN B-O
+- PUNCT B-O
+β PUNCT B-O
+- PUNCT B-O
+actin NOUN B-O
+in ADP B-O
+eNOS PROPN B-AC
+and CCONJ B-O
+G2A NOUN B-O
+T NOUN B-O
+cells NOUN B-O
+, PUNCT B-O
+stimulated VERB B-O
+on ADP B-O
+CD3 PROPN B-O
+Ab PROPN B-O
+- PUNCT B-O
+coated VERB B-O
+chambers NOUN B-O
+. PUNCT B-O
+
+Free ADJ B-O
+fatty ADJ B-LF
+acid NOUN I-LF
+( PUNCT B-O
+FA PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+polar ADJ B-O
+lipid NOUN B-O
+species NOUN B-O
+were AUX B-O
+determined VERB B-O
+in ADP B-O
+flowers NOUN B-O
+and CCONJ B-O
+caulinary ADJ B-O
+leaves NOUN B-O
+of ADP B-O
+7 NUM B-O
+- PUNCT B-O
+week NOUN B-O
+- PUNCT B-O
+old ADJ B-O
+, PUNCT B-O
+mature ADJ B-O
+flowering VERB B-O
+plants NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+substances NOUN B-O
+which PRON B-O
+mainly ADV B-O
+contributed VERB B-O
+to ADP B-O
+Ozone PROPN B-LF
+layer NOUN I-LF
+depletion NOUN I-LF
+( PUNCT B-O
+OLD PROPN B-AC
+) PUNCT B-O
+were AUX B-O
+Methane PROPN B-O
+, PUNCT B-O
+bromotrifluoro- NOUN B-O
+, PUNCT B-O
+Halon PROPN B-O
+1301 NUM B-O
+( PUNCT B-O
+7.16E-06 NUM B-O
+kg NOUN B-O
+CFC-11 NOUN B-O
+eq NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+Methane PROPN B-O
+, PUNCT B-O
+trichlorofluoro NOUN B-O
+CFC-11 NOUN B-O
+( PUNCT B-O
+7.28559E-11 NUM B-O
+kg NOUN B-O
+CFC-11 NOUN B-O
+eq NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+There PRON B-O
+is VERB B-O
+an DET B-O
+increasing VERB B-O
+expectation NOUN B-O
+that SCONJ B-O
+CHWs PROPN B-AC
+will AUX B-O
+participate VERB B-O
+in ADP B-O
+disease NOUN B-O
+surveillance NOUN B-O
+and CCONJ B-O
+data NOUN B-O
+collection NOUN B-O
+, PUNCT B-O
+diagnosis NOUN B-O
+and CCONJ B-O
+referral NOUN B-O
+for ADP B-O
+care NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+antiretroviral ADJ B-LF
+therapy NOUN I-LF
+( PUNCT B-O
+ART PROPN B-AC
+) PUNCT B-O
+provision NOUN B-O
+[ PUNCT B-O
+10 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+( PUNCT B-O
+A X B-O
+) PUNCT B-O
+Trimethoprim NOUN B-O
++ SYM B-O
+sulfamethizole NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+B X B-O
+) PUNCT B-O
+Trimethoprim NOUN B-O
++ SYM B-O
+AZT PROPN B-AC
+. PUNCT B-O
+
+Synergistic ADJ B-O
+fractional ADJ B-LF
+inhibitory ADJ I-LF
+concentration NOUN I-LF
+index NOUN I-LF
+( PUNCT B-O
+FICI PROPN B-AC
+) PUNCT B-O
+values NOUN B-O
+( PUNCT B-O
+≤0.5 NUM B-O
+) PUNCT B-O
+are AUX B-O
+marked VERB B-O
+with ADP B-O
+yellow ADJ B-O
+bars NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+nonsynergistic ADJ B-O
+( PUNCT B-O
+FICI PROPN B-AC
+> SYM B-O
+0.5 NUM B-O
+) PUNCT B-O
+FICI PROPN B-AC
+values NOUN B-O
+are AUX B-O
+marked VERB B-O
+with ADP B-O
+blue ADJ B-O
+bars NOUN B-O
+. PUNCT B-O
+
+However ADV B-O
+, PUNCT B-O
+Zbtb7a NOUN B-O
+is AUX B-O
+not PART B-O
+restricted VERB B-O
+to PART B-O
+NFκB PROPN B-AC
+target NOUN B-O
+promoters NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+indeed ADV B-O
+, PUNCT B-O
+a DET B-O
+large ADJ B-O
+fraction NOUN B-O
+of ADP B-O
+all DET B-O
+genomic ADJ B-O
+promoters NOUN B-O
+are AUX B-O
+associated VERB B-O
+with ADP B-O
+overlapping VERB B-O
+— PUNCT B-O
+or CCONJ B-O
+nearby ADJ B-O
+— PUNCT B-O
+Zbtb7a NOUN B-O
+binding NOUN B-O
+( PUNCT B-O
+up ADP B-O
+to PART B-O
+17 NUM B-O
+% PUNCT B-O
+or CCONJ B-O
+41 NUM B-O
+% PUNCT B-O
+, PUNCT B-O
+respectively ADV B-O
+, PUNCT B-O
+of ADP B-O
+all DET B-O
+promoters NOUN B-O
+in ADP B-O
+fibroblasts NOUN B-O
+; PUNCT B-O
+Fig PROPN B-O
+2D NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+with ADP B-O
+a DET B-O
+preference NOUN B-O
+for ADP B-O
+guanine NOUN B-LF
+- PUNCT I-LF
+cytosine NOUN I-LF
+( PUNCT B-O
+GC)-rich PROPN B-AC
+and CCONJ B-O
+CpG NOUN B-LF
+island NOUN I-LF
+( PUNCT B-O
+CGI)-containing PROPN B-AC
+promoters NOUN B-O
+( PUNCT B-O
+S2H PROPN B-O
+and CCONJ B-O
+S2I PROPN B-O
+Fig PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+LUSC PROPN B-AC
+( PUNCT B-O
+lung NOUN B-LF
+squamous ADJ I-LF
+cell NOUN I-LF
+carcinoma NOUN I-LF
+) PUNCT B-O
+Based VERB B-O
+on ADP B-O
+observations NOUN B-O
+in ADP B-O
+Drosophila PROPN B-O
+[ PUNCT B-O
+5 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+we PRON B-O
+set VERB B-O
+out ADP B-O
+to PART B-O
+assess VERB B-O
+the DET B-O
+role NOUN B-O
+of ADP B-O
+stress NOUN B-O
+- PUNCT B-O
+response NOUN B-O
+pathways NOUN B-O
+, PUNCT B-O
+particularly ADV B-O
+of ADP B-O
+heat NOUN B-LF
+shock NOUN I-LF
+protein NOUN I-LF
+90 NUM I-LF
+( PUNCT B-O
+Hsp90 PROPN B-AC
+) PUNCT B-O
+function NOUN B-O
+, PUNCT B-O
+in ADP B-O
+phenotype NOUN B-O
+modification NOUN B-O
+, PUNCT B-O
+using VERB B-O
+zebrafish NOUN B-O
+as ADP B-O
+a DET B-O
+vertebrate ADJ B-O
+model NOUN B-O
+. PUNCT B-O
+
+Driving VERB B-LF
+simulator NOUN I-LF
+( PUNCT B-O
+DS PROPN B-AC
+) PUNCT B-O
+systems NOUN B-O
+have VERB B-O
+advantages NOUN B-O
+in ADP B-O
+controlling VERB B-O
+traffic- NOUN B-O
+and CCONJ B-O
+automobile NOUN B-O
+- PUNCT B-O
+related VERB B-O
+conditions NOUN B-O
+[ PUNCT B-O
+1,13,14 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+We PRON B-O
+assumed VERB B-O
+a DET B-O
+50 NUM B-O
+% NOUN B-O
+proportion NOUN B-O
+, PUNCT B-O
+80 NUM B-O
+% NOUN B-O
+power NOUN B-O
+, PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+confidence NOUN B-LF
+interval NOUN I-LF
+( PUNCT B-O
+CI PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+5 NUM B-O
+% NOUN B-O
+precision NOUN B-O
+. PUNCT B-O
+
+All DET B-O
+known VERB B-O
+AP PROPN B-AC
+endonucleases NOUN B-O
+are AUX B-O
+grouped VERB B-O
+in ADP B-O
+two NUM B-O
+distinct ADJ B-O
+superfamilies NOUN B-O
+based VERB B-O
+on ADP B-O
+their PRON B-O
+structural ADJ B-O
+and CCONJ B-O
+sequence NOUN B-O
+similarity NOUN B-O
+to ADP B-O
+either CCONJ B-O
+Escherichia PROPN B-LF
+coli PROPN I-LF
+exonuclease NOUN I-LF
+III NUM I-LF
+( PUNCT B-O
+Xth PROPN B-AC
+; PUNCT B-O
+Endonuclease NOUN B-LF
+— PUNCT I-LF
+Exonuclease NOUN I-LF
+— PUNCT I-LF
+Phosphatase NOUN I-LF
+superfamily NOUN B-O
+, PUNCT B-O
+or CCONJ B-O
+EEP PROPN B-AC
+) PUNCT B-O
+or CCONJ B-O
+endonuclease NOUN B-O
+IV NUM B-O
+( PUNCT B-O
+Nfo PROPN B-O
+) PUNCT B-O
+[ PUNCT B-O
+10 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Arm PROPN B-AC
+, PUNCT B-O
+Armadillo PROPN B-LF
+; PUNCT B-O
+bGal PROPN B-AC
+, PUNCT B-O
+beta NOUN B-LF
+- PUNCT I-LF
+galactosidase NOUN I-LF
+; PUNCT B-O
+Cyt PROPN B-AC
+-Arm PROPN B-AC
+, PUNCT B-O
+Cytoplasm NOUN B-O
+- PUNCT B-O
+Armadillo PROPN B-LF
+; PUNCT B-O
+GBSC PROPN B-AC
+, PUNCT B-O
+glioblastoma NOUN B-LF
+multiforme ADJ I-LF
+stem NOUN I-LF
+- PUNCT I-LF
+like ADJ I-LF
+cell NOUN I-LF
+; PUNCT B-O
+GFP PROPN B-AC
+, PUNCT B-O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT B-O
+igl PROPN B-AC
+, PUNCT B-O
+igloo NOUN B-LF
+; PUNCT B-O
+myrRFP PROPN B-O
+, PUNCT B-O
+myristoilated PROPN B-O
+Red PROPN B-O
+Fluorescent PROPN B-O
+Protein PROPN B-O
+; PUNCT B-O
+nkd PROPN B-AC
+, PUNCT B-O
+-lacZnkd PROPN B-AC
+, PUNCT B-O
+transcriptional ADJ B-O
+beta NOUN B-LF
+- PUNCT I-LF
+galactosidase NOUN I-LF
+reporter NOUN B-O
+of ADP B-O
+naked ADJ B-O
+gene NOUN B-O
+NLGN3 PROPN B-O
+; PUNCT B-O
+NMRI PROPN B-O
+, PUNCT B-O
+Naval PROPN B-O
+Medical PROPN B-O
+Research PROPN B-O
+Institute PROPN B-O
+. PUNCT B-O
+
+Very ADV B-LF
+- PUNCT I-LF
+long ADV I-LF
+- PUNCT I-LF
+chain NOUN I-LF
+fatty ADJ I-LF
+acid NOUN I-LF
+( PUNCT B-O
+VLCFA PROPN B-AC
+) PUNCT B-O
+accumulation NOUN B-O
+has AUX B-O
+long ADV B-O
+been AUX B-O
+suggested VERB B-O
+as ADP B-O
+a DET B-O
+major ADJ B-O
+disease NOUN B-O
+- PUNCT B-O
+mediating VERB B-O
+factor NOUN B-O
+, PUNCT B-O
+although SCONJ B-O
+the DET B-O
+exact ADJ B-O
+pathological ADJ B-O
+consequences NOUN B-O
+are AUX B-O
+unclear ADJ B-O
+. PUNCT B-O
+
+Unexpectedly ADV B-O
+, PUNCT B-O
+we PRON B-O
+found VERB B-O
+that SCONJ B-O
+Notch1 NOUN B-O
+- PUNCT B-O
+expressing VERB B-O
+cells NOUN B-O
+invariably ADV B-O
+lacked VERB B-O
+the DET B-O
+expression NOUN B-O
+of ADP B-O
+ERα PROPN B-AC
+and CCONJ B-O
+PR PROPN B-AC
+( PUNCT B-O
+Fig PROPN B-O
+. PUNCT B-O
+
+2F NUM B-O
+, PUNCT B-O
+G NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
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+we PRON B-O
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+Real ADJ I-LF
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+Chain PROPN I-LF
+Reaction PROPN I-LF
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+qRT PROPN B-AC
+) PUNCT B-O
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+sorted ADJ B-O
+-PCRGFP PROPN B-AC
+- PUNCT B-O
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+( PUNCT B-O
+S3B PROPN B-O
+, PUNCT B-O
+C PROPN B-O
+Fig PROPN B-O
+. PUNCT B-O
+
+) PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+RSV PROPN B-AC
+infected VERB B-O
+animals NOUN B-O
+treated VERB B-O
+with ADP B-O
+EGY-2 PROPN B-AC
+, PUNCT B-O
+alveolar ADJ B-LF
+macrophages NOUN I-LF
+( PUNCT B-O
+AM PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+the DET B-O
+high ADJ B-O
+dose NOUN B-O
+group NOUN B-O
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+a DET B-O
+markedly ADV B-O
+enhanced VERB B-O
+phagocytic ADJ B-O
+function NOUN B-O
+at ADP B-O
+the DET B-O
+early ADJ B-O
+phase NOUN B-O
+of ADP B-O
+infection NOUN B-O
+, PUNCT B-O
+as ADP B-O
+both CCONJ B-O
+the DET B-O
+number NOUN B-O
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+phagocytic ADJ B-O
+AM PROPN B-AC
+as ADP B-O
+well ADV B-O
+as ADP B-O
+their PRON B-O
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+compared VERB B-O
+to ADP B-O
+untreated ADJ B-O
+animals NOUN B-O
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+1 NUM B-O
+p.i PROPN B-AC
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+
+( PUNCT B-O
+Fig NOUN B-O
+4A NUM B-O
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+4B NOUN B-O
+, PUNCT B-O
+respectively ADV B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Finally ADV B-O
+, PUNCT B-O
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+a DET B-O
+sensitivity NOUN B-O
+analysis NOUN B-O
+, PUNCT B-O
+we PRON B-O
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+genetic ADJ B-LF
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+scores NOUN I-LF
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+hair NOUN B-O
+color NOUN B-O
+, PUNCT B-O
+skin NOUN B-O
+phototype NOUN B-O
+, PUNCT B-O
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+the DET B-O
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+freckles NOUN B-O
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+tanning NOUN B-O
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+, PUNCT B-O
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+our PRON B-O
+data NOUN B-O
+( PUNCT B-O
+S2 PROPN B-O
+Table PROPN B-O
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+we PRON B-O
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+their PRON B-O
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+cancer NOUN B-O
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+for ADP B-O
+the DET B-O
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+
+SDQ PROPN B-AC
+, PUNCT B-O
+Strengths NOUN B-LF
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+Difficulties NOUN I-LF
+Questionnaire NOUN I-LF
+. PUNCT B-O
+
+In ADP B-O
+Drosophila PROPN B-O
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+( PUNCT B-O
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+genes NOUN B-O
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+4],[5 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+DIC PROPN B-AC
+, PUNCT B-O
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+interference NOUN I-LF
+contrast NOUN I-LF
+; PUNCT B-O
+SM PROPN B-O
+, PUNCT B-O
+Sperm NOUN B-O
+Medium NOUN B-O
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+In ADP B-O
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+, PUNCT B-O
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+) PUNCT B-O
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+the DET B-O
+care NOUN B-O
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+vascular ADJ B-O
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+adults NOUN B-O
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+Aptima PROPN B-LF
+HIV-1 NOUN I-LF
+Aptima PROPN B-AC
+Quant NOUN I-LF
+Dx NOUN I-LF
+assay NOUN I-LF
+Equation NOUN B-O
+2 NUM B-O
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+is AUX B-O
+number NOUN B-O
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+predictions NOUN B-O
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+Various ADJ B-O
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+, PUNCT B-O
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+IHC PROPN B-AC
+, PUNCT B-O
+SS PROPN B-AC
+, PUNCT B-O
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+( PUNCT B-O
+PS PROPN B-AC
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+, PUNCT B-O
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+to PART B-O
+analyze VERB B-O
+genetic ADJ B-O
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+profiles NOUN B-O
+in ADP B-O
+clinical ADJ B-O
+tissue NOUN B-O
+samples NOUN B-O
+. PUNCT B-O
+
+One NUM B-O
+compound NOUN B-O
+seemed VERB B-O
+a DET B-O
+particularly ADV B-O
+promising ADJ B-O
+candidate NOUN B-O
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+this DET B-O
+sort NOUN B-O
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+approach NOUN B-O
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+( PUNCT B-O
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+, PUNCT B-O
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+40 NUM B-O
+years NOUN B-O
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+Though SCONJ B-O
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+endemic ADJ B-O
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+] PUNCT B-O
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+( PUNCT B-O
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+- PUNCT B-O
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+( PUNCT B-O
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+] PUNCT B-O
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+Ethical ADJ B-O
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+Greater PROPN B-O
+Manchester PROPN B-O
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+Ethics PROPN B-O
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+( PUNCT B-O
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+18 NUM B-O
+/ NUM B-O
+NW/0211 NUM B-O
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+Health PROPN I-LF
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+NHS PROPN B-AC
+) PUNCT B-O
+Health PROPN B-O
+Research PROPN B-O
+Authority PROPN B-O
+( PUNCT B-O
+project NOUN B-O
+reference NOUN B-O
+244772 NUM B-O
+) PUNCT B-O
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+For ADP B-O
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+women NOUN B-LF
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+HIV PROPN I-LF
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+( PUNCT B-O
+WLHIV PROPN B-AC
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+it PRON B-O
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+in ADP B-O
+care NOUN B-O
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+their PRON B-O
+pregnancy NOUN B-O
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+so SCONJ B-O
+that SCONJ B-O
+they PRON B-O
+receive VERB B-O
+the DET B-O
+full ADJ B-O
+package NOUN B-O
+of ADP B-O
+prevention NOUN B-O
+of ADP B-O
+mother NOUN B-O
+- PUNCT B-O
+to ADP B-O
+- PUNCT B-O
+child NOUN B-O
+transmission NOUN B-O
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+HIV PROPN B-AC
+( PUNCT B-O
+PMTCT PROPN B-AC
+) PUNCT B-O
+services NOUN B-O
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+
+Primer NOUN B-O
+pairs NOUN B-O
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+for ADP B-O
+three NUM B-O
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+open ADJ B-LF
+reading NOUN I-LF
+frame NOUN I-LF
+( PUNCT B-O
+ORF PROPN B-AC
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+regions NOUN B-O
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+ASH1 PROPN B-O
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+ADH1 PROPN B-O
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+chromosome NOUN B-O
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+Dahlbäck PROPN B-O
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+. PUNCT B-O
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+observed VERB B-O
+that SCONJ B-O
+addition NOUN B-O
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+APC PROPN B-AC
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+plasma NOUN B-O
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+patients NOUN B-O
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+multiple ADJ B-O
+thrombotic ADJ B-O
+events NOUN B-O
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+not PART B-O
+result VERB B-O
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+expected VERB B-O
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+( PUNCT B-O
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+assay NOUN B-O
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+1 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
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+Graphs NOUN B-O
+illustrate VERB B-O
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+scenarios NOUN B-O
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+order NOUN B-O
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+performance NOUN B-O
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+( PUNCT B-O
+Root NOUN B-O
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+Error NOUN B-O
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+MAE PROPN B-AC
+( PUNCT B-O
+Mean NOUN B-LF
+Absolute PROPN I-LF
+Error NOUN I-LF
+) PUNCT B-O
+, PUNCT B-O
+R NOUN B-O
+- PUNCT B-O
+squared NOUN B-O
+and CCONJ B-O
+Spearman PROPN B-O
+correlation NOUN B-O
+coefficient NOUN B-O
+. PUNCT B-O
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+Risky ADJ B-O
+sexual ADJ B-O
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+serious ADJ B-O
+health NOUN B-O
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+unintended ADJ B-O
+pregnancy NOUN B-O
+, PUNCT B-O
+abortion NOUN B-O
+, PUNCT B-O
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+infections NOUN I-LF
+( PUNCT B-O
+STIs PROPN B-AC
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+HIV PROPN B-AC
+[ PUNCT B-O
+19 NUM B-O
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+In ADP B-O
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+settings NOUN I-LF
+( PUNCT B-O
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+, PUNCT B-O
+treatment NOUN B-O
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+jaundice NOUN B-O
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+often ADV B-O
+sub ADJ B-O
+- ADJ B-O
+optimal ADJ B-O
+[ PUNCT B-O
+4 NUM B-O
+, PUNCT B-O
+5 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
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+In ADP B-O
+2015 NUM B-O
+, NOUN B-O
+the DET B-O
+prevalence NOUN B-O
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+low ADJ B-O
+birth NOUN B-O
+weight NOUN B-O
+per ADP B-O
+100 NUM B-O
+births NOUN B-O
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+southern ADJ B-O
+Asia PROPN B-O
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+- ADJ B-O
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+( PUNCT B-O
+26.4 NUM B-O
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+uncertainty NOUN B-LF
+range NOUN I-LF
+[ PUNCT B-O
+UR PROPN B-AC
+] PUNCT B-O
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+18.6–35.2 NUM B-O
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+14.0 NUM B-O
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+UR PROPN B-AC
+: PUNCT B-O
+12.2–17.2 NUM B-O
+) PUNCT B-O
+[ PUNCT B-O
+28 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Three NUM B-O
+retinoic ADJ B-LF
+acid NOUN I-LF
+receptors NOUN B-O
+( PUNCT B-O
+RARα PROPN B-O
+, PUNCT B-O
+RARβ PROPN B-O
+and CCONJ B-O
+RARγ NOUN B-O
+) PUNCT B-O
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+been AUX B-O
+identified VERB B-O
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+receptors NOUN B-O
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+These DET B-O
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+- PUNCT B-O
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+= PUNCT B-O
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+= PUNCT B-O
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+Measure NOUN I-LF
+; PUNCT B-O
+MACS PROPN B-AC