data/test.conll

Abbreviations NOUN B-O
: PUNCT B-O
GEMS PROPN B-AC
, PUNCT B-O
Global PROPN B-LF
Enteric PROPN I-LF
Multicenter PROPN I-LF
Study PROPN I-LF
; PUNCT B-O
VIP PROPN B-AC
, PUNCT B-O
ventilated VERB B-LF
improved ADJ I-LF
pit NOUN I-LF
. PUNCT B-O

Fractions NOUN B-O
from ADP B-O
FPLC PROPN B-O
purification NOUN B-O
were AUX B-O
treated VERB B-O
with ADP B-O
Laemmli PROPN B-O
buffer NOUN B-O
[ X B-O
82 X B-O
] X B-O
with ADP B-O
10 NUM B-O
mM NOUN B-O
1,4 NUM B-O
- PUNCT B-O
dithiothreitol NOUN B-LF
( PUNCT B-O
DTT PROPN B-AC
) PUNCT B-O
and CCONJ B-O
heated VERB B-O
for ADP B-O
5 NUM B-O
m NOUN B-O
at ADP B-O
85 NUM B-O
° NOUN B-O
C NOUN B-O
then ADV B-O
analyzed VERB B-O
on ADP B-O
a DET B-O
4 NUM B-O
% NOUN B-O
to PART B-O
15 NUM B-O
% NOUN B-O
discontinuous ADJ B-O
SDS PROPN B-AC
gel NOUN B-O
with ADP B-O
a DET B-O
6 NUM B-O
% NOUN B-O
stacking NOUN B-O
gel NOUN B-O
run VERB B-O
at ADP B-O
ambient ADJ B-O
temperature NOUN B-O
at ADP B-O
a DET B-O
constant ADJ B-O
100 NUM B-O
V. NOUN B-O
Two NUM B-O
epithelial ADJ B-O
cytokines NOUN B-O
other ADJ B-O
than ADP B-O
IL33 NOUN B-O
, PUNCT B-O
IL25 NOUN B-O
, PUNCT B-O
and CCONJ B-O
thymic ADJ B-LF
stromal ADJ I-LF
lymphopoietin NOUN I-LF
( PUNCT B-O
TSLP PROPN B-AC
) PUNCT B-O
are AUX B-O
known VERB B-O
to PART B-O
activate VERB B-O
ILC2 PROPN B-AC
in ADP B-O
the DET B-O
lung NOUN B-O
[ PUNCT B-O
22,24 NUM B-O
] PUNCT B-O
. PUNCT B-O

We PRON B-O
developed VERB B-O
a DET B-O
variant NOUN B-O
of ADP B-O
gene NOUN B-LF
set NOUN I-LF
enrichment NOUN I-LF
analysis NOUN I-LF
( PUNCT B-O
GSEA PROPN B-AC
) PUNCT B-O
to PART B-O
determine VERB B-O
whether SCONJ B-O
a DET B-O
genetic ADJ B-O
pathway NOUN B-O
shows VERB B-O
evidence NOUN B-O
for ADP B-O
age NOUN B-O
regulation NOUN B-O
[ PUNCT B-O
23 NUM B-O
] PUNCT B-O
. PUNCT B-O

Red NOUN B-O
represents VERB B-O
samples NOUN B-O
having VERB B-O
the DET B-O
normalized VERB B-O
pY232 PROPN B-AC
and/or CCONJ B-O
pY291 NOUN B-O
values NOUN B-O
in ADP B-O
cancer NOUN B-O
tissues NOUN B-O
≥ PUNCT B-O
1.1 NUM B-O
folds NOUN B-O
of ADP B-O
normal ADJ B-O
tissues NOUN B-O
( PUNCT B-O
of ADP B-O
which PRON B-O
enhanced VERB B-O
pY232 PROPN B-AC
and/or CCONJ B-O
pY291 NOUN B-O
level NOUN B-O
may AUX B-O
be AUX B-O
indicative ADJ B-O
of ADP B-O
dominant ADJ B-O
survival NOUN B-O
mode NOUN B-O
of ADP B-O
Fas PROPN B-O
signaling NOUN B-O
) PUNCT B-O
; PUNCT B-O
blue NOUN B-O
represents VERB B-O
samples NOUN B-O
having VERB B-O
both CCONJ B-O
normalized VERB B-O
pY232 PROPN B-AC
and CCONJ B-O
pY291 NOUN B-O
values NOUN B-O
< ADP B-O
1.1 NUM B-O
( PUNCT B-O
of ADP B-O
which PRON B-O
pY232 PROPN B-AC
and CCONJ B-O
pY291 NOUN B-O
levels NOUN B-O
less ADJ B-O
than ADP B-O
or CCONJ B-O
equal ADJ B-O
to ADP B-O
normal ADJ B-O
may AUX B-O
be AUX B-O
indicative ADJ B-O
of ADP B-O
the DET B-O
apoptosis NOUN B-O
- NOUN B-O
ready ADJ B-O
mode NOUN B-O
of ADP B-O
Fas PROPN B-O
signaling NOUN B-O
) PUNCT B-O
. PUNCT B-O

( PUNCT B-O
D X B-O
) PUNCT B-O
Lysates NOUN B-O
of ADP B-O
rectal ADJ B-O
cancer NOUN B-O
tissues NOUN B-O
before ADP B-O
and CCONJ B-O
after ADP B-O
radiotherapy NOUN B-LF
( PUNCT B-O
RT PROPN B-AC
) PUNCT B-O
from ADP B-O
each PRON B-O
of ADP B-O
the DET B-O
nine NUM B-O
patients NOUN B-O
were AUX B-O
subjected VERB B-O
to ADP B-O
SDS PROPN B-O
- NOUN B-O
PAGE PROPN B-O
and CCONJ B-O
immunoblotting NOUN B-O
with ADP B-O
antibodies NOUN B-O
against ADP B-O
pY232 PROPN B-AC
, PUNCT B-O
pY291 NOUN B-O
, PUNCT B-O
and CCONJ B-O
C NOUN B-O
- NOUN B-O
terminal ADJ B-O
( PUNCT B-O
C NOUN B-O
- NOUN B-O
ter NOUN B-O
) PUNCT B-O
of ADP B-O
Fas PROPN B-O
. PUNCT B-O

Relative ADJ B-LF
risks NOUN I-LF
( PUNCT B-O
RRs PROPN B-AC
) PUNCT B-O
with ADP B-O
95 NUM B-O
% NOUN B-O
confidence NOUN B-LF
intervals NOUN I-LF
( PUNCT B-O
CIs PROPN B-AC
) PUNCT B-O
are AUX B-O
reported VERB B-O
. PUNCT B-O

Increasing VERB B-O
concentrations NOUN B-O
of ADP B-O
the DET B-O
p53 NOUN B-O
activators NOUN B-O
significantly ADV B-O
decrease NOUN B-O
the DET B-O
levels NOUN B-O
of ADP B-O
SOD1G85R PROPN B-O
but CCONJ B-O
not PART B-O
the DET B-O
endogenous ADJ B-O
WTSOD1 PROPN B-AC
proteins NOUN B-O
in ADP B-O
western ADJ B-O
blots NOUN B-O
of ADP B-O
both CCONJ B-O
supernatant NOUN B-O
and CCONJ B-O
pellet NOUN B-LF
fractions NOUN I-LF
. PUNCT B-O

( PUNCT B-O
B X B-O
) PUNCT B-O
A DET B-O
decrease NOUN B-O
in ADP B-O
p53 NOUN B-O
as SCONJ B-O
the DET B-O
result NOUN B-O
of ADP B-O
shRNA PROPN B-AC
knockdown NOUN B-O
increases VERB B-O
the DET B-O
levels NOUN B-O
of ADP B-O
SOD1G85R PROPN B-O
but CCONJ B-O
not PART B-O
WT PROPN B-AC
SOD1 PROPN B-AC
proteins NOUN B-O
in ADP B-O
the DET B-O
SOD1G85R PROPN B-O
aggregation NOUN B-O
assay NOUN B-O
, PUNCT B-O
as SCONJ B-O
shown VERB B-O
by ADP B-O
western ADJ B-O
blots NOUN B-O
of ADP B-O
both CCONJ B-O
supernatant NOUN B-O
( PUNCT B-O
S PROPN B-AC
) PUNCT B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
2 NUM B-O
) PUNCT B-O
and CCONJ B-O
pellet NOUN B-O
( PUNCT B-O
P PROPN B-AC
) PUNCT B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
3 NUM B-O
) PUNCT B-O
fractions NOUN B-O
. PUNCT B-O

( PUNCT B-O
C X B-O
) PUNCT B-O
A DET B-O
complete ADJ B-O
absence NOUN B-O
of ADP B-O
p53 NOUN B-O
increases VERB B-O
the DET B-O
accumulation NOUN B-O
of ADP B-O
SOD1G85R PROPN B-O
mutant ADJ B-O
proteins NOUN B-O
in ADP B-O
p53–/ NOUN B-O
– PUNCT B-O
HCT116 PROPN B-O
cells NOUN B-O
when SCONJ B-O
compared VERB B-O
with ADP B-O
controls NOUN B-O
. PUNCT B-O

Pravastatin ADJ B-LF
sodium NOUN I-LF
( PUNCT B-O
PSS PROPN B-AC
, PUNCT B-O
Fig NOUN B-O
2.9 NUM B-O
) PUNCT B-O
is AUX B-O
the DET B-O
only ADJ B-O
included VERB B-O
NP PROPN B-AC
of ADP B-O
microbial ADJ B-O
origin NOUN B-O
. PUNCT B-O

I PRON B-O
have VERB B-O
read VERB B-O
the DET B-O
journal NOUN B-O
's PART B-O
policy NOUN B-O
and CCONJ B-O
the DET B-O
authors NOUN B-O
of ADP B-O
this DET B-O
manuscript NOUN B-O
have VERB B-O
the DET B-O
following VERB B-O
competing VERB B-O
interests NOUN B-O
: PUNCT B-O
DF PROPN B-O
, PUNCT B-O
EJ PROPN B-O
, PUNCT B-O
and CCONJ B-O
NNL PROPN B-O
are AUX B-O
staff NOUN B-O
members NOUN B-O
of ADP B-O
the DET B-O
World PROPN B-LF
Health PROPN I-LF
Organization PROPN I-LF
( PUNCT B-O
WHO PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Characteristics NOUN B-O
were AUX B-O
compared VERB B-O
across ADP B-O
the DET B-O
matched VERB B-O
groups NOUN B-O
using VERB B-O
standardized ADJ B-LF
mean ADJ I-LF
differences NOUN I-LF
( PUNCT B-O
SMDs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
with ADP B-O
an DET B-O
SMD PROPN B-AC
> ADP B-O
0.1 NUM B-O
indicating VERB B-O
a DET B-O
clinically ADV B-O
important ADJ B-O
difference NOUN B-O
. PUNCT B-O

Nutrients NOUN B-O
that PRON B-O
are AUX B-O
rich ADJ B-O
in ADP B-O
seafood NOUN B-O
were AUX B-O
selected VERB B-O
to PART B-O
be AUX B-O
included VERB B-O
this DET B-O
study NOUN B-O
: PUNCT B-O
protein NOUN B-O
, PUNCT B-O
eicosapentaenoic NOUN B-LF
acid NOUN I-LF
( PUNCT B-O
EPA PROPN B-AC
) PUNCT B-O
and CCONJ B-O
docosahexaenoic NOUN B-LF
acid NOUN I-LF
( PUNCT B-O
DHA PROPN B-AC
) PUNCT B-O
, PUNCT B-O
vitamins NOUN B-O
( PUNCT B-O
A NOUN B-O
, PUNCT B-O
D NOUN B-O
, PUNCT B-O
B12 NOUN B-O
, PUNCT B-O
and CCONJ B-O
niacin NOUN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
minerals NOUN B-O
( PUNCT B-O
zinc NOUN B-O
and CCONJ B-O
selenium NOUN B-O
, PUNCT B-O
and CCONJ B-O
iron NOUN B-O
) PUNCT B-O
. PUNCT B-O

To PART B-O
test VERB B-O
if SCONJ B-O
this DET B-O
polymorphism NOUN B-O
modulates VERB B-O
CD24 NOUN B-O
mRNA NOUN B-O
stability NOUN B-O
, PUNCT B-O
we PRON B-O
constructed VERB B-O
two NUM B-O
plasmids NOUN B-O
( PUNCT B-O
pTracer PROPN B-O
CMV2 NOUN B-O
- PUNCT B-O
CD24TG NOUN B-O
and CCONJ B-O
pTracer PROPN B-O
CMV2 NOUN B-O
- PUNCT B-O
CD24del NOUN B-O
; PUNCT B-O
Figure PROPN B-O
5 NUM B-O
, PUNCT B-O
top ADJ B-O
panel NOUN B-O
) PUNCT B-O
and CCONJ B-O
transfected VERB B-O
Chinese ADJ B-LF
hamster NOUN I-LF
ovary NOUN I-LF
( PUNCT B-O
CHO PROPN B-AC
) PUNCT B-O
cells NOUN B-O
with ADP B-O
the DET B-O
two NUM B-O
constructs NOUN B-O
. PUNCT B-O

Blood NOUN B-LF
pressure NOUN I-LF
( PUNCT B-O
BP PROPN B-AC
) PUNCT B-O
will AUX B-O
be AUX B-O
controlled VERB B-O
after ADP B-O
each DET B-O
visit NOUN B-O
. PUNCT B-O

Briefly ADV B-O
, PUNCT B-O
Phenotypic ADJ B-O
Age PROPN B-O
is AUX B-O
calculated VERB B-O
using VERB B-O
chronological ADJ B-O
age NOUN B-O
and CCONJ B-O
9 NUM B-O
biomarkers NOUN B-O
( PUNCT B-O
albumin NOUN B-O
, PUNCT B-O
creatinine NOUN B-O
, PUNCT B-O
glucose NOUN B-O
, PUNCT B-O
[ PUNCT B-O
log X B-O
] PUNCT B-O
C NOUN B-LF
- NOUN I-LF
reactive ADJ I-LF
protein NOUN I-LF
[ PUNCT B-O
CRP PROPN B-AC
] PUNCT B-O
, PUNCT B-O
lymphocyte NOUN B-O
percent NOUN B-O
, PUNCT B-O
mean ADJ B-O
cell NOUN B-O
volume NOUN B-O
, PUNCT B-O
red ADJ B-O
blood NOUN B-O
cell NOUN B-O
distribution NOUN B-O
width NOUN B-O
, PUNCT B-O
alkaline ADJ B-O
phosphatase NOUN B-O
, PUNCT B-O
and CCONJ B-O
white ADJ B-O
blood NOUN B-O
cell NOUN B-O
count NOUN B-O
) PUNCT B-O
that PRON B-O
were AUX B-O
selected VERB B-O
using VERB B-O
a DET B-O
Cox PROPN B-O
proportional ADJ B-O
hazard NOUN B-O
elastic ADJ B-O
net NOUN B-O
model NOUN B-O
for ADP B-O
mortality NOUN B-O
based VERB B-O
on ADP B-O
10 ADJ B-O
- NOUN B-O
fold ADJ B-O
cross NOUN B-O
- NOUN B-O
validation NOUN B-O
. PUNCT B-O

However ADV B-O
, PUNCT B-O
c NOUN B-O
- PUNCT B-O
Fos NOUN B-O
, PUNCT B-O
PStat3 PROPN B-O
, PUNCT B-O
and CCONJ B-O
PIP3 PROPN B-AC
formation NOUN B-O
were AUX B-O
not PART B-O
elevated VERB B-O
in ADP B-O
response NOUN B-O
to ADP B-O
leptin NOUN B-O
in ADP B-O
obese ADJ B-O
GSL PROPN B-O
- PUNCT B-O
deficient ADJ B-O
mice NOUN B-O
6 NUM B-O
wk PROPN B-AC
p.i NOUN B-O
. PUNCT B-O

( PUNCT B-O
Figures NOUN B-O
7A NUM B-O
, PUNCT B-O
B NOUN B-O
and CCONJ B-O
S10A NOUN B-O
) PUNCT B-O
. PUNCT B-O

No DET B-O
significant ADJ B-O
changes NOUN B-O
were AUX B-O
found VERB B-O
in ADP B-O
mediobasal ADJ B-LF
hypothalamus NOUN I-LF
( PUNCT B-O
MBH PROPN B-AC
) PUNCT B-O
baseline NOUN B-O
mRNA NOUN B-O
expression NOUN B-O
of ADP B-O
Pomc PROPN B-O
and CCONJ B-O
cocaine- NOUN B-O
and CCONJ B-O
amphetamine NOUN B-O
- PUNCT B-O
regulated VERB B-O
transcript NOUN B-O
( PUNCT B-O
Cart PROPN B-O
) PUNCT B-O
mRNA NOUN B-O
6 NUM B-O
wk PROPN B-AC
p.i NOUN B-O
. PUNCT B-O

( PUNCT B-O
Figure NOUN B-O
S10B NOUN B-O
) PUNCT B-O
. PUNCT B-O

It PRON B-O
has AUX B-O
been AUX B-O
found VERB B-O
that SCONJ B-O
control NOUN B-O
has AUX B-O
been AUX B-O
centered VERB B-O
around ADP B-O
cyclin NOUN B-LF
- PUNCT I-LF
dependent ADJ I-LF
protein NOUN I-LF
kinases NOUN I-LF
( PUNCT B-O
CDKs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
trigger VERB B-O
the DET B-O
major ADJ B-O
events NOUN B-O
of ADP B-O
the DET B-O
eukaryotic ADJ B-O
cell NOUN B-O
cycle NOUN B-O
. PUNCT B-O

The DET B-O
asparagine NOUN B-O
hydroxylase NOUN B-O
, PUNCT B-O
termed VERB B-O
factor NOUN B-LF
inhibiting VERB I-LF
HIF NOUN I-LF
HIF PROPN B-AC
( PUNCT B-O
FIH PROPN B-AC
) PUNCT B-O
( PUNCT B-O
Uniprot ADJ B-O
accession NOUN B-O
number NOUN B-O
: PUNCT B-O
Q9NWT6 NOUN B-O
) PUNCT B-O
, PUNCT B-O
hydroxylates VERB B-O
an DET B-O
asparagine NOUN B-O
residue NOUN B-O
within ADP B-O
HIFα NOUN B-O
subunits NOUN B-O
( PUNCT B-O
N803 NUM B-O
on ADP B-O
HIF-1α PROPN B-AC
) PUNCT B-O
, PUNCT B-O
resulting VERB B-O
in ADP B-O
steric ADJ B-O
inhibition NOUN B-O
of ADP B-O
its PRON B-O
interaction NOUN B-O
with ADP B-O
the DET B-O
transcriptional ADJ B-O
co NOUN B-O
- PUNCT B-O
activator NOUN B-O
p300 NOUN B-O
/ SYM B-O
CBP PROPN B-O
, PUNCT B-O
thereby ADV B-O
inhibiting VERB B-O
HIF PROPN B-AC
- PUNCT B-O
dependent ADJ B-O
transcription NOUN B-O
[ PUNCT B-O
2 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
manuscript NOUN B-O
by ADP B-O
Varma PROPN B-O
et PROPN B-O
al NOUN B-O
explores VERB B-O
the DET B-O
relationships NOUN B-O
between ADP B-O
bile NOUN B-LF
acid NOUN I-LF
( PUNCT B-O
BA PROPN B-AC
) PUNCT B-O
levels NOUN B-O
/ SYM B-O
synthesis NOUN B-O
and CCONJ B-O
dementia NOUN B-O
related VERB B-O
pathology NOUN B-O
, PUNCT B-O
such ADJ B-O
as ADP B-O
white ADJ B-LF
matter NOUN I-LF
lesions NOUN I-LF
( PUNCT B-O
WML PROPN B-AC
) PUNCT B-O
and CCONJ B-O
amyloid NOUN B-O
deposition NOUN B-O
, PUNCT B-O
as ADP B-O
well ADV B-O
as ADP B-O
vascular ADJ B-O
dementia NOUN B-O
risk NOUN B-O
and CCONJ B-O
sex NOUN B-O
related VERB B-O
differences NOUN B-O
. PUNCT B-O

However ADV B-O
, PUNCT B-O
current ADJ B-O
literature NOUN B-O
on ADP B-O
the DET B-O
stability NOUN B-O
of ADP B-O
the DET B-O
steroids NOUN B-O
in ADP B-O
DBS PROPN B-AC
is AUX B-O
very ADV B-O
limited ADJ B-O
, PUNCT B-O
dealing VERB B-O
exclusively ADV B-O
with ADP B-O
17OHP PROPN B-AC
[ PUNCT B-O
10–16 NUM B-O
] PUNCT B-O
or CCONJ B-O
cortisol NOUN B-LF
( PUNCT B-O
Cort PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
17 NUM B-O
] PUNCT B-O
. PUNCT B-O

CD PROPN B-AC
is AUX B-O
the DET B-O
most ADV B-O
common ADJ B-O
form NOUN B-O
of ADP B-O
inflammatory ADJ B-O
bowel NOUN B-O
disease NOUN B-O
, PUNCT B-O
the DET B-O
other ADJ B-O
being AUX B-O
ulcerative ADJ B-LF
colitis NOUN I-LF
( PUNCT B-O
UC PROPN B-AC
) PUNCT B-O
. PUNCT B-O

We PRON B-O
genotyped VERB B-O
a DET B-O
cohort NOUN B-O
of ADP B-O
246 NUM B-O
Belgian ADJ B-O
UC PROPN B-AC
patients NOUN B-O
( PUNCT B-O
Caucasians PROPN B-O
) PUNCT B-O
for ADP B-O
IL23R NOUN B-O
( PUNCT B-O
rs11209026 NUM B-O
) PUNCT B-O
, PUNCT B-O
ATG16L1 NOUN B-O
( PUNCT B-O
rs2241880 NUM B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
novel ADJ B-O
5p13.1 NOUN B-O
locus NOUN B-O
( PUNCT B-O
rs4613763 NUM B-O
) PUNCT B-O
. PUNCT B-O

Endophthalmitis NOUN B-O
after ADP B-O
vitreous ADJ B-O
surgery NOUN B-O
is AUX B-O
an DET B-O
uncommon ADJ B-O
but CCONJ B-O
a DET B-O
devastating ADJ B-O
complication.[1 NOUN B-O
] PUNCT B-O
The DET B-O
reported VERB B-O
incidence NOUN B-O
of ADP B-O
endophthalmitis NOUN B-O
after ADP B-O
vitreous ADJ B-O
surgery NOUN B-O
ranges VERB B-O
from ADP B-O
0.05 NUM B-O
% NOUN B-O
to ADP B-O
0.02 NUM B-O
% NOUN B-O
with ADP B-O
20 NUM B-O
- ADJ B-O
G NOUN B-O
vitrectomy.[2–10 NOUN B-O
] PUNCT B-O
Initial ADJ B-O
reports NOUN B-O
showed VERB B-O
higher ADJ B-O
rates NOUN B-O
of ADP B-O
post ADJ B-O
- ADJ B-O
minimally ADJ B-LF
invasive ADJ I-LF
vitreoretinal ADJ I-LF
surgery NOUN I-LF
( PUNCT B-O
MIVS PROPN B-AC
) PUNCT B-O
endophthalmitis NOUN B-O
, PUNCT B-O
whereas SCONJ B-O
recent ADJ B-O
reports NOUN B-O
have AUX B-O
shown VERB B-O
a DET B-O
declining VERB B-O
trend.[6,8,10,11 NUM B-O
] PUNCT B-O
Body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT B-O
BMI PROPN B-AC
) PUNCT B-O
was AUX B-O
calculated VERB B-O
as ADP B-O
the DET B-O
weight NOUN B-O
in ADP B-O
kilograms NOUN B-O
divided VERB B-O
by ADP B-O
the DET B-O
square NOUN B-O
of ADP B-O
the DET B-O
height NOUN B-O
in ADP B-O
meters NOUN B-O
. PUNCT B-O

Source NOUN B-O
data NOUN B-O
are AUX B-O
available ADJ B-O
from ADP B-O
https://figshare.com/s/b14c8e6cb1fc5135dd87 X B-O
. PUNCT B-O

# PUNCT B-O
Cells NOUN B-O
, PUNCT B-O
number NOUN B-O
of ADP B-O
cells NOUN B-O
; PUNCT B-O
μ PUNCT B-O
CA PROPN B-O
, PUNCT B-O
average ADJ B-O
cell NOUN B-O
area NOUN B-O
; PUNCT B-O
LATE PROPN B-AC
, PUNCT B-O
a DET B-LF
timing NOUN I-LF
factor NOUN I-LF
; PUNCT B-O
Leaf NOUN B-O
A NOUN B-O
, PUNCT B-O
leaf NOUN B-O
area NOUN B-O
; PUNCT B-O
spch PROPN B-AC
, PUNCT B-O
speechless ADJ B-LF
. PUNCT B-O

The DET B-O
best ADJ B-LF
linear ADJ I-LF
unbiased ADJ I-LF
estimates NOUN I-LF
( PUNCT B-O
BLUEs PROPN B-AC
) PUNCT B-O
of ADP B-O
the DET B-O
481 NUM B-O
BC1F3:4 NOUN B-O
families NOUN B-O
were AUX B-O
estimated VERB B-O
following VERB B-O
the DET B-O
model NOUN B-O
: PUNCT B-O
yijm NOUN B-O
= SYM B-O
μ+gi+ej+geij+δ(j)m+εijm X B-O
, PUNCT B-O
where SCONJ B-O
yijm NOUN B-O
is AUX B-O
the DET B-O
phenotype NOUN B-O
of ADP B-O
the DET B-O
ith NOUN B-O
( PUNCT B-O
i NOUN B-O
= SYM B-O
1,2 NUM B-O
… PUNCT B-O
, PUNCT B-O
481 NUM B-O
) PUNCT B-O
genotype NOUN B-O
in ADP B-O
the DET B-O
jth NOUN B-O
( PUNCT B-O
j NOUN B-O
= SYM B-O
1,2,3,4 NUM B-O
) PUNCT B-O
environment NOUN B-O
, PUNCT B-O
the DET B-O
mth NOUN B-O
( PUNCT B-O
m NOUN B-O
= SYM B-O
1,2 NUM B-O
) PUNCT B-O
replicate NOUN B-O
effect NOUN B-O
was AUX B-O
nested VERB B-O
in ADP B-O
each DET B-O
environment NOUN B-O
. PUNCT B-O

μ PUNCT B-O
is AUX B-O
the DET B-O
overall ADJ B-O
mean NOUN B-O
, PUNCT B-O
gi NOUN B-O
is AUX B-O
the DET B-O
genotype NOUN B-O
effect NOUN B-O
, PUNCT B-O
ej NOUN B-O
is AUX B-O
the DET B-O
environmental ADJ B-O
effect NOUN B-O
, PUNCT B-O
geij NOUN B-O
is AUX B-O
the DET B-O
G×E PROPN B-AC
effect NOUN B-O
, PUNCT B-O
δ(j)m NOUN B-O
is AUX B-O
the DET B-O
replicate NOUN B-O
effect NOUN B-O
, PUNCT B-O
and CCONJ B-O
εijm NOUN B-O
~ PUNCT B-O
N NOUN B-O
( PUNCT B-O
0 NUM B-O
, PUNCT B-O
σε2 NUM B-O
) PUNCT B-O
is AUX B-O
the DET B-O
error NOUN B-O
term NOUN B-O
. PUNCT B-O

KO PROPN B-AC
, PUNCT B-O
knockout NOUN B-LF
; PUNCT B-O
PSD PROPN B-AC
, PUNCT B-O
postsynaptic ADJ B-LF
density NOUN I-LF
. PUNCT B-O

Small ADJ B-O
RNA NOUN B-O
sequencing NOUN B-O
was AUX B-O
performed VERB B-O
to PART B-O
profile VERB B-O
miRNA PROPN B-AC
expression NOUN B-O
in ADP B-O
SW480 NUM B-O
and CCONJ B-O
SW620 NUM B-O
cell NOUN B-LF
lysates NOUN I-LF
( PUNCT B-O
CLs PROPN B-AC
) PUNCT B-O
and CCONJ B-O
their PRON B-O
released VERB B-O
EVs PROPN B-AC
. PUNCT B-O

Initially ADV B-O
, PUNCT B-O
a DET B-O
total NOUN B-O
of ADP B-O
160.46 NUM B-O
million NUM B-O
raw ADJ B-O
reads NOUN B-O
were AUX B-O
generated VERB B-O
by ADP B-O
an DET B-O
Illumina PROPN B-O
HiSeq-2000 PROPN B-O
system NOUN B-O
for ADP B-O
all DET B-O
the DET B-O
samples NOUN B-O
, PUNCT B-O
yielding VERB B-O
an DET B-O
average ADJ B-O
12.77 NUM B-O
million NUM B-O
clean ADJ B-O
reads NOUN B-O
. PUNCT B-O

Inter- ADJ B-O
and CCONJ B-O
intra ADJ B-O
- PUNCT B-O
rater ADJ B-O
reliability NOUN B-O
was AUX B-O
determined VERB B-O
by ADP B-O
means NOUN B-O
of ADP B-O
intraclass NOUN B-LF
correlation NOUN I-LF
coefficients NOUN I-LF
( PUNCT B-O
ICC PROPN B-AC
) PUNCT B-O
using VERB B-O
R PROPN B-O
Studio PROPN B-O
( PUNCT B-O
Version PROPN B-O
1.1.456 NUM B-O
; PUNCT B-O
RStudio PROPN B-O
) PUNCT B-O
based VERB B-O
on ADP B-O
a DET B-O
mean NOUN B-O
of ADP B-O
2 NUM B-O
raters NOUN B-O
, PUNCT B-O
consistency NOUN B-O
, PUNCT B-O
2 NUM B-O
- PUNCT B-O
way NOUN B-O
mixed VERB B-O
- PUNCT B-O
effects NOUN B-O
model NOUN B-O
for ADP B-O
the DET B-O
qualitative ADJ B-O
analysis NOUN B-O
[ PUNCT B-O
42 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
signaling NOUN B-O
molecule NOUN B-O
secreted VERB B-O
by ADP B-O
the DET B-O
hypothalamus NOUN B-O
is AUX B-O
arginine NOUN B-LF
vasopressin NOUN I-LF
( PUNCT B-O
AVP PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
binds VERB B-O
to ADP B-O
a DET B-O
specific ADJ B-O
protein NOUN B-O
on ADP B-O
the DET B-O
surface NOUN B-O
of ADP B-O
kidney NOUN B-O
cells NOUN B-O
, PUNCT B-O
AVP PROPN B-AC
receptor NOUN B-O
( PUNCT B-O
AVPR2 PROPN B-AC
) PUNCT B-O
. PUNCT B-O

The DET B-O
results NOUN B-O
described VERB B-O
above ADV B-O
show VERB B-O
that PRON B-O
membrane NOUN B-O
- PUNCT B-O
tethered VERB B-O
δ PUNCT B-O
- PUNCT B-O
ACTX NOUN B-O
- PUNCT B-O
Hv1a PROPN B-O
expression NOUN B-O
in ADP B-O
PDF PROPN B-AC
- PUNCT B-O
secreting VERB B-O
LNVs PROPN B-AC
induces VERB B-O
a DET B-O
phase NOUN B-O
- PUNCT B-O
advance NOUN B-O
of ADP B-O
both CCONJ B-O
sLNV PROPN B-AC
PDF PROPN B-AC
secretion NOUN B-O
rhythms NOUN B-O
and CCONJ B-O
morning ADJ B-O
anticipatory ADJ B-O
locomotor ADJ B-O
behavior NOUN B-O
in ADP B-O
LD PROPN B-AC
, PUNCT B-O
and CCONJ B-O
disrupts VERB B-O
free ADV B-O
- PUNCT B-O
running VERB B-O
locomotor ADJ B-O
rhythms NOUN B-O
in ADP B-O
DD PROPN B-AC
. PUNCT B-O

In ADP B-O
order NOUN B-O
to PART B-O
determine VERB B-O
the DET B-O
relationship NOUN B-O
between ADP B-O
these DET B-O
phenotypes NOUN B-O
and CCONJ B-O
cellular ADJ B-O
transcriptional ADJ B-O
feedback NOUN B-O
oscillation NOUN B-O
, PUNCT B-O
par PROPN B-LF
domain NOUN I-LF
protein NOUN I-LF
1 NUM I-LF
( PUNCT B-O
PDP1 PROPN B-AC
) PUNCT B-O
clock NOUN B-O
protein NOUN B-O
levels NOUN B-O
were AUX B-O
assayed VERB B-O
in ADP B-O
the DET B-O
sLNV PROPN B-AC
, PUNCT B-O
dorsal ADJ B-LF
lateral ADJ I-LF
neuron NOUN I-LF
( PUNCT B-O
LND PROPN B-AC
) PUNCT B-O
, PUNCT B-O
dorsal ADJ B-LF
neuron NOUN I-LF
( PUNCT B-O
DN)1 PROPN B-AC
, PUNCT B-O
and CCONJ B-O
DN2 NOUN B-O
neurons NOUN B-O
of ADP B-O
flies NOUN B-O
expressing VERB B-O
membrane NOUN B-O
- PUNCT B-O
tethered VERB B-O
δ PUNCT B-O
- PUNCT B-O
ACTX NOUN B-O
- PUNCT B-O
Hv1a PROPN B-O
in ADP B-O
the DET B-O
LNVs PROPN B-AC
. PUNCT B-O

PDP1 PROPN B-AC
is AUX B-O
an DET B-O
oscillating VERB B-O
transcription NOUN B-O
factor NOUN B-O
that PRON B-O
has AUX B-O
been AUX B-O
implicated VERB B-O
in ADP B-O
a DET B-O
second ADJ B-O
interlocking VERB B-O
circadian ADJ B-O
transcriptional ADJ B-O
feedback NOUN B-O
loop NOUN B-O
[ PUNCT B-O
8 NUM B-O
] PUNCT B-O
. PUNCT B-O

Mosquitoes NOUN B-O
were AUX B-O
allowed VERB B-O
to ADP B-O
feed VERB B-O
on ADP B-O
a DET B-O
human NOUN B-O
, PUNCT B-O
then ADV B-O
, PUNCT B-O
24 NUM B-O
h NOUN B-O
after ADP B-O
the DET B-O
blood NOUN B-O
feeding NOUN B-O
, PUNCT B-O
gut NOUN B-O
sections NOUN B-O
were AUX B-O
prepared VERB B-O
for ADP B-O
histology NOUN B-O
and CCONJ B-O
stained VERB B-O
with ADP B-O
hematoxylin NOUN B-LF
and CCONJ I-LF
eosin NOUN I-LF
( PUNCT B-O
HE PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Compared VERB B-O
to ADP B-O
non ADJ B-O
- PUNCT B-O
transgenic ADJ B-O
midguts NOUN B-O
which PRON B-O
were AUX B-O
filled VERB B-O
with ADP B-O
intact ADJ B-O
erythrocytes NOUN B-O
( PUNCT B-O
Figure PROPN B-O
5A NUM B-O
and CCONJ B-O
5C NUM B-O
) PUNCT B-O
, PUNCT B-O
erythrocytes NOUN B-O
in ADP B-O
the DET B-O
midgut NOUN B-O
of ADP B-O
transgenic ADJ B-O
mosquito NOUN B-O
were AUX B-O
extensively ADV B-O
hemolyzed VERB B-O
( PUNCT B-O
Figure PROPN B-O
5B NUM B-O
and CCONJ B-O
5D NUM B-O
) PUNCT B-O
. PUNCT B-O

Lymphocytes NOUN B-O
were AUX B-O
clearly ADV B-O
contrasted VERB B-O
in ADP B-O
the DET B-O
midgut NOUN B-O
of ADP B-O
transgenic ADJ B-O
mosquito NOUN B-O
( PUNCT B-O
Figure PROPN B-O
5D NUM B-O
) PUNCT B-O
, PUNCT B-O
but CCONJ B-O
not PART B-O
amongst ADP B-O
the DET B-O
intact ADJ B-O
erythrocytes NOUN B-O
in ADP B-O
the DET B-O
midgut NOUN B-O
of ADP B-O
non ADJ B-O
- PUNCT B-O
transgenic ADJ B-O
mosquito NOUN B-O
( PUNCT B-O
Figure PROPN B-O
5C NUM B-O
) PUNCT B-O
. PUNCT B-O

These DET B-O
results NOUN B-O
are AUX B-O
consistent ADJ B-O
with ADP B-O
the DET B-O
data NOUN B-O
shown VERB B-O
in ADP B-O
Figure PROPN B-O
3C NUM B-O
, PUNCT B-O
where SCONJ B-O
the DET B-O
secretion NOUN B-O
of ADP B-O
CEL NOUN B-O
- PUNCT B-O
III NUM B-O
into ADP B-O
the DET B-O
midgut NOUN B-O
lumen NOUN B-O
caused VERB B-O
effective ADJ B-O
hemolysis NOUN B-O
. PUNCT B-O

PM2.5 PROPN B-AC
, PUNCT B-O
fine ADJ B-LF
particulate ADJ I-LF
matter NOUN I-LF
( PUNCT B-O
particulate ADJ B-O
matter NOUN B-O
with ADP B-O
a DET B-O
diameter NOUN B-O
of ADP B-O
< ADP B-O
2.5 NUM B-O
μm NOUN B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
glycosphingolipid NOUN B-O
isoglobotrihexosylceramide NOUN B-O
, PUNCT B-O
or CCONJ B-O
isogloboside NOUN B-LF
3 NUM I-LF
( PUNCT B-O
iGb3 PROPN B-AC
) PUNCT B-O
, PUNCT B-O
is AUX B-O
believed VERB B-O
to PART B-O
be AUX B-O
critical ADJ B-O
for ADP B-O
natural ADJ B-LF
killer NOUN I-LF
T PROPN I-LF
( PUNCT B-O
NKT PROPN B-AC
) PUNCT B-O
cell NOUN B-O
development NOUN B-O
and CCONJ B-O
self NOUN B-O
- PUNCT B-O
recognition NOUN B-O
in ADP B-O
mice NOUN B-O
and CCONJ B-O
humans NOUN B-O
. PUNCT B-O

Other ADJ B-O
authors NOUN B-O
[ X B-O
16,17 X B-O
] X B-O
have AUX B-O
proposed VERB B-O
different ADJ B-O
methods NOUN B-O
for ADP B-O
continuous ADJ B-O
nICP PROPN B-AC
monitoring NOUN B-O
based VERB B-O
on ADP B-O
the DET B-O
waveform NOUN B-O
analysis NOUN B-O
of ADP B-O
cerebral ADJ B-O
blood NOUN B-O
flow NOUN B-O
velocity NOUN B-O
from ADP B-O
the DET B-O
middle ADJ B-LF
cerebral ADJ I-LF
artery NOUN I-LF
( PUNCT B-O
MCA PROPN B-AC
) PUNCT B-O
and CCONJ B-O
arterial ADJ B-O
pressure NOUN B-O
. PUNCT B-O

The DET B-O
median ADJ B-O
age NOUN B-O
of ADP B-O
women NOUN B-O
screened VERB B-O
was AUX B-O
25 NUM B-O
years NOUN B-O
( PUNCT B-O
interquartile ADJ B-LF
range NOUN I-LF
[ PUNCT B-O
IQR PROPN B-AC
] PUNCT B-O
: PUNCT B-O
22–29 NUM B-O
) PUNCT B-O
, PUNCT B-O
8 NUM B-O
% NOUN B-O
( PUNCT B-O
105/1,271 NUM B-O
) PUNCT B-O
were AUX B-O
< ADP B-O
20 NUM B-O
years NOUN B-O
old ADJ B-O
, PUNCT B-O
and CCONJ B-O
49 NUM B-O
% NOUN B-O
( PUNCT B-O
627/1,271 NUM B-O
) PUNCT B-O
were AUX B-O
< ADP B-O
24 NUM B-O
years NOUN B-O
old ADJ B-O
; PUNCT B-O
82 NUM B-O
% NOUN B-O
( PUNCT B-O
1,026/1,271 NUM B-O
) PUNCT B-O
were AUX B-O
married ADJ B-O
, PUNCT B-O
and CCONJ B-O
more ADJ B-O
than ADP B-O
a DET B-O
third ADJ B-O
( PUNCT B-O
427/1,271 NUM B-O
) PUNCT B-O
of ADP B-O
the DET B-O
women NOUN B-O
did AUX B-O
not PART B-O
know VERB B-O
their PRON B-O
male ADJ B-O
partners NOUN B-O
’ PUNCT B-O
HIV PROPN B-O
status NOUN B-O
( PUNCT B-O
Table PROPN B-O
1 NUM B-O
) PUNCT B-O
. PUNCT B-O

In ADP B-O
a DET B-O
' PUNCT B-O
status X B-O
quo X B-O
' PUNCT B-O
setting NOUN B-O
, PUNCT B-O
the DET B-O
VMMC PROPN B-AC
program NOUN B-O
could AUX B-O
be AUX B-O
accompanied VERB B-O
by ADP B-O
continuations NOUN B-O
of ADP B-O
recent ADJ B-O
trends NOUN B-O
in ADP B-O
antiretroviral ADJ B-LF
therapy NOUN I-LF
( PUNCT B-O
ART PROPN B-AC
) PUNCT B-O
scale NOUN B-O
- ADJ B-O
up NOUN B-O
, PUNCT B-O
with ADP B-O
constant ADJ B-O
coverage NOUN B-O
of ADP B-O
prevention NOUN B-O
interventions NOUN B-O
and CCONJ B-O
constant ADJ B-O
rates NOUN B-O
of ADP B-O
risk NOUN B-O
and CCONJ B-O
( PUNCT B-O
non ADJ B-O
- ADJ B-O
VMMC PROPN B-AC
) PUNCT B-O
protective ADJ B-O
behaviors NOUN B-O
. PUNCT B-O

This DET B-O
study NOUN B-O
included VERB B-O
31 NUM B-O
women NOUN B-O
who PRON B-O
delivered VERB B-O
small ADJ B-LF
for ADP I-LF
gestational ADJ I-LF
age NOUN I-LF
( PUNCT B-O
SGA PROPN B-AC
) PUNCT B-O
babies NOUN B-O
( PUNCT B-O
SGA PROPN B-AC
, PUNCT B-O
≤10th ADJ B-O
percentile NOUN B-O
) PUNCT B-O
, PUNCT B-O
28 NUM B-O
who PRON B-O
delivered VERB B-O
large ADJ B-LF
for ADP I-LF
gestational ADJ I-LF
age NOUN I-LF
( PUNCT B-O
LGA PROPN B-AC
) PUNCT B-O
babies NOUN B-O
( PUNCT B-O
≥90th ADJ B-O
percentile NOUN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
31 NUM B-O
who PRON B-O
delivered VERB B-O
appropriate ADJ B-LF
for ADP I-LF
gestational ADJ I-LF
age NOUN I-LF
( PUNCT B-O
AGA PROPN B-AC
) PUNCT B-O
babies NOUN B-O
( PUNCT B-O
controls NOUN B-O
, PUNCT B-O
> NUM B-O
10th ADJ B-O
to PART B-O
< NUM B-O
90th NUM B-O
percentile NOUN B-O
) PUNCT B-O
. PUNCT B-O

Most ADV B-O
strikingly ADV B-O
, PUNCT B-O
the DET B-O
strongly ADV B-O
conserved VERB B-O
proline NOUN B-LF
( PUNCT B-O
Pro PROPN B-AC
) PUNCT B-O
residue NOUN B-O
at ADP B-O
site NOUN B-O
283 NUM B-O
in ADP B-O
NP PROPN B-AC
is AUX B-O
rendered VERB B-O
highly ADV B-O
unfit ADJ B-O
by ADP B-O
HSF1 PROPN B-AC
inhibition NOUN B-O
at ADP B-O
febrile ADJ B-O
temperatures NOUN B-O
. PUNCT B-O

The DET B-O
microRNA NOUN B-LF
( PUNCT B-O
miRNA PROPN B-AC
) PUNCT B-O
miR-148a NOUN B-O
is AUX B-O
a DET B-O
17- NUM B-O
to ADP B-O
25 NUM B-O
- ADJ B-O
nucleotide NOUN B-O
( PUNCT B-O
nt)-long ADJ B-O
highly ADV B-O
conserved ADJ B-O
single ADJ B-O
- ADJ B-O
stranded ADJ B-O
non ADJ B-O
- ADJ B-O
coding ADJ B-O
RNA NOUN B-O
regulating VERB B-O
the DET B-O
expression NOUN B-O
of ADP B-O
target NOUN B-O
genes NOUN B-O
at ADP B-O
the DET B-O
post ADJ B-O
- ADJ B-O
transcriptional ADJ B-O
level NOUN B-O
by ADP B-O
binding VERB B-O
to ADP B-O
the DET B-O
complementary ADJ B-O
sites NOUN B-O
of ADP B-O
the DET B-O
mRNA NOUN B-O
of ADP B-O
specific ADJ B-O
target NOUN B-O
genes NOUN B-O
[ PUNCT B-O
4 NUM B-O
] PUNCT B-O
. PUNCT B-O

While SCONJ B-O
FGF PROPN B-AC
primarily ADV B-O
induces VERB B-O
the DET B-O
Ras PROPN B-O
– PUNCT B-O
Mitogen PROPN B-LF
- PUNCT I-LF
Activated PROPN I-LF
Protein PROPN I-LF
Kinase PROPN I-LF
( PUNCT B-O
MAPK PROPN B-AC
) PUNCT B-O
axis NOUN B-O
to PART B-O
promote VERB B-O
lens NOUN B-O
cell NOUN B-O
differentiation NOUN B-O
, PUNCT B-O
PDGF PROPN B-AC
preferentially ADV B-O
stimulates VERB B-O
Phosphoinositide NOUN B-LF
3 NUM I-LF
- PUNCT I-LF
kinase NOUN I-LF
( PUNCT B-O
PI3 PROPN B-AC
) PUNCT B-O
to PART B-O
enhance VERB B-O
Notch NOUN B-O
signaling NOUN B-O
, PUNCT B-O
which PRON B-O
is AUX B-O
necessary ADJ B-O
for ADP B-O
maintaining VERB B-O
the DET B-O
lens NOUN B-O
progenitor NOUN B-O
cell NOUN B-O
pool NOUN B-O
. PUNCT B-O

To PART B-O
begin VERB B-O
to PART B-O
establish VERB B-O
such ADJ B-O
links NOUN B-O
between ADP B-O
genotype NOUN B-O
and CCONJ B-O
growth NOUN B-O
phenotype NOUN B-O
, PUNCT B-O
we PRON B-O
developed VERB B-O
a DET B-O
computer NOUN B-O
model NOUN B-O
for ADP B-O
the DET B-O
intracellular ADJ B-O
growth NOUN B-O
of ADP B-O
vesicular NOUN B-LF
stomatitis NOUN I-LF
virus NOUN I-LF
( PUNCT B-O
VSV PROPN B-AC
) PUNCT B-O
, PUNCT B-O
a DET B-O
well ADV B-O
- PUNCT B-O
studied VERB B-O
, PUNCT B-O
nonsegmented ADJ B-O
, PUNCT B-O
negative ADJ B-O
- PUNCT B-O
stranded ADJ B-O
RNA NOUN B-O
virus NOUN B-O
. PUNCT B-O

Legend NOUN B-O
: PUNCT B-O
HCV PROPN B-AC
: PUNCT B-O
Chronic ADJ B-O
hepatitis NOUN B-O
C NOUN B-O
; PUNCT B-O
DAA PROPN B-AC
: PUNCT B-O
Direct ADV B-LF
- PUNCT I-LF
acting VERB I-LF
antivirals NOUN I-LF
; PUNCT B-O
N NOUN B-O
: PUNCT B-O
Sample NOUN B-O
size NOUN B-O
; PUNCT B-O
comorbidities NOUN B-O
: PUNCT B-O
Comorbidity NOUN B-O
; PUNCT B-O
comedications NOUN B-O
: PUNCT B-O
Comedication NOUN B-O
. PUNCT B-O

Time NOUN B-O
to ADP B-O
ART PROPN B-AC
initiation NOUN B-O
was AUX B-O
estimated VERB B-O
using VERB B-O
cumulative ADJ B-LF
incidence NOUN I-LF
functions NOUN I-LF
( PUNCT B-O
CIFs PROPN B-AC
): PUNCT B-O
mortality NOUN B-O
and CCONJ B-O
LTFU PROPN B-AC
were AUX B-O
considered VERB B-O
competing VERB B-O
events NOUN B-O
to ADP B-O
ART PROPN B-AC
initiation NOUN B-O
[ PUNCT B-O
9 NUM B-O
] PUNCT B-O
, PUNCT B-O
while SCONJ B-O
those PRON B-O
transferred VERB B-O
out ADV B-O
were AUX B-O
right ADV B-O
- PUNCT B-O
censored VERB B-O
, PUNCT B-O
with ADP B-O
the DET B-O
assumption NOUN B-O
that SCONJ B-O
they PRON B-O
remained VERB B-O
in ADP B-O
HIV PROPN B-O
care NOUN B-O
and CCONJ B-O
had VERB B-O
similar ADJ B-O
outcomes NOUN B-O
as ADP B-O
patients NOUN B-O
still ADV B-O
in ADP B-O
observation NOUN B-O
. PUNCT B-O

FISH PROPN B-AC
, PUNCT B-O
fluorescence NOUN B-LF
in ADP I-LF
situ NOUN I-LF
hybridization NOUN I-LF
. PUNCT B-O

We PRON B-O
included VERB B-O
those PRON B-O
with ADP B-O
follow VERB B-O
- PUNCT B-O
up ADP B-O
visits NOUN B-O
and CCONJ B-O
pulmonary ADJ B-LF
function NOUN I-LF
tests NOUN I-LF
( PUNCT B-O
PFTs PROPN B-AC
) PUNCT B-O
available ADJ B-O
after ADP B-O
hospitalization NOUN B-O
. PUNCT B-O

WT PROPN B-O
, PUNCT B-O
wild ADJ B-O
type NOUN B-O
; PUNCT B-O
TG PROPN B-AC
, PUNCT B-O
transgenic ADJ B-O
; PUNCT B-O
TSA PROPN B-AC
, PUNCT B-O
total ADJ B-LF
salvianolic ADJ I-LF
acid NOUN I-LF
; PUNCT B-O
n NOUN B-O
= SYM B-O
20 NUM B-O
, PUNCT B-O
error NOUN B-O
bars NOUN B-O
represent VERB B-O
SEM NOUN B-O
. PUNCT B-O

* NOUN B-O
p<0.05 NUM B-O
, PUNCT B-O
* NOUN B-O
* NOUN B-O
p<0.01 NUM B-O
versus ADP B-O
WT PROPN B-O
control NOUN B-O
group NOUN B-O
; PUNCT B-O
# SYM B-O
p<0.05 NUM B-O
, PUNCT B-O
# SYM B-O
# SYM B-O
p<0.01 NUM B-O
versus ADP B-O
vehicle NOUN B-O
- PUNCT B-O
treated VERB B-O
APPswe PROPN B-O
/ SYM B-O
PS1dE9 PROPN B-O
transgenic ADJ B-O
group NOUN B-O
. PUNCT B-O

M PROPN B-O
, PUNCT B-O
mirror NOUN B-O
; PUNCT B-O
P NOUN B-O
, PUNCT B-O
pinhole NOUN B-O
; PUNCT B-O
λ/2 NUM B-O
, PUNCT B-O
λ/2 NUM B-O
plate NOUN B-O
; PUNCT B-O
PBS PROPN B-AC
, PUNCT B-O
polarizing VERB B-LF
beam NOUN I-LF
splitter NOUN I-LF
; PUNCT B-O
EOM PROPN B-O
, PUNCT B-O
electro ADJ B-O
optical ADJ B-O
modulator NOUN B-O
; PUNCT B-O
S NOUN B-O
, PUNCT B-O
shutter NOUN B-O
; PUNCT B-O
F NOUN B-O
, PUNCT B-O
filter NOUN B-O
; PUNCT B-O
Pol PROPN B-O
, PUNCT B-O
polarizer NOUN B-O
; PUNCT B-O
DC NOUN B-O
, PUNCT B-O
dichroic ADJ B-O
mirror NOUN B-O
. PUNCT B-O

In ADP B-O
the DET B-O
third ADJ B-O
group NOUN B-O
, PUNCT B-O
the DET B-O
variables NOUN B-O
related VERB B-O
to ADP B-O
resuming VERB B-O
dialysis NOUN B-O
were AUX B-O
: PUNCT B-O
Charlson PROPN B-O
comorbidity NOUN B-O
index NOUN B-O
[ PUNCT B-O
18 NUM B-O
] PUNCT B-O
; PUNCT B-O
dialysis NOUN B-O
modality NOUN B-O
and CCONJ B-O
access NOUN B-O
, PUNCT B-O
such ADJ B-O
as ADP B-O
arterio ADJ B-O
- PUNCT B-O
venous ADJ B-O
( PUNCT B-O
AV PROPN B-AC
) PUNCT B-O
fistula NOUN B-O
as ADP B-O
access NOUN B-O
for ADP B-O
hemodialysis NOUN B-O
, PUNCT B-O
venous ADJ B-O
catheters NOUN B-O
, PUNCT B-O
or CCONJ B-O
peritoneal ADJ B-O
catheters NOUN B-O
for ADP B-O
peritoneal ADJ B-O
dialysis NOUN B-O
; PUNCT B-O
and CCONJ B-O
biochemical ADJ B-O
parameters NOUN B-O
such ADJ B-O
as ADP B-O
creatinine NOUN B-O
, PUNCT B-O
hemoglobin NOUN B-O
, PUNCT B-O
urea NOUN B-O
, PUNCT B-O
potassium NOUN B-O
, PUNCT B-O
ionic ADJ B-O
calcium NOUN B-O
, PUNCT B-O
phosphorus NOUN B-O
, PUNCT B-O
parathormone NOUN B-LF
( PUNCT B-O
PTH PROPN B-AC
) PUNCT B-O
, PUNCT B-O
serum NOUN B-O
albumin NOUN B-O
and CCONJ B-O
C NOUN B-O
- PUNCT B-O
reactive ADJ B-O
protein NOUN B-O
. PUNCT B-O

HPD PROPN B-AC
, PUNCT B-O
human ADJ B-LF
population NOUN I-LF
density NOUN I-LF
. PUNCT B-O

PD PROPN B-AC
; PUNCT B-O
the DET B-O
ERK PROPN B-O
inhibitor NOUN B-O
PD98059 PROPN B-LF
. PUNCT B-O

β PUNCT B-O
- PUNCT B-O
Actin PROPN B-O
served VERB B-O
as ADP B-O
an DET B-O
input NOUN B-O
control NOUN B-O
. PUNCT B-O

( PUNCT B-O
G NOUN B-O
) PUNCT B-O
Levels NOUN B-O
of ADP B-O
inflammatory ADJ B-O
response NOUN B-O
markers NOUN B-O
( PUNCT B-O
NF NOUN B-O
- PUNCT B-O
κB NOUN B-O
p65 NOUN B-O
activity NOUN B-O
and CCONJ B-O
TNFα PROPN B-O
and CCONJ B-O
IL-8 PROPN B-AC
production NOUN B-O
, PUNCT B-O
by ADP B-O
ELISA PROPN B-O
) PUNCT B-O
in ADP B-O
control NOUN B-O
medium NOUN B-O
- PUNCT B-O
treated VERB B-O
or CCONJ B-O
CSE PROPN B-AC
- PUNCT B-O
exposed VERB B-O
H292 PROPN B-O
cells NOUN B-O
, PUNCT B-O
pretreated VERB B-O
with ADP B-O
either CCONJ B-O
Csn-B PROPN B-AC
( PUNCT B-O
10 NUM B-O
μM NOUN B-O
) PUNCT B-O
or CCONJ B-O
Veh PROPN B-AC
. PUNCT B-O

( PUNCT B-O
left ADJ B-O
panel NOUN B-O
) PUNCT B-O
Spectrophotometric ADJ B-O
reading NOUN B-O
value NOUN B-O
( PUNCT B-O
A450 NOUN B-O
) PUNCT B-O
represents VERB B-O
NF NOUN B-O
- PUNCT B-O
κB NOUN B-O
p65 NOUN B-O
activity NOUN B-O
. PUNCT B-O

( PUNCT B-O
middle ADJ B-O
and CCONJ B-O
right ADJ B-O
panels NOUN B-O
) PUNCT B-O
The DET B-O
levels NOUN B-O
of ADP B-O
cytokine NOUN B-O
and CCONJ B-O
chemokine NOUN B-O
are AUX B-O
shown VERB B-O
as ADP B-O
protein NOUN B-O
concentrations NOUN B-O
( PUNCT B-O
pg NOUN B-O
) PUNCT B-O
in ADP B-O
ml NOUN B-O
of ADP B-O
cell NOUN B-O
culture NOUN B-O
medium NOUN B-O
. PUNCT B-O

The DET B-O
EP3 NOUN B-O
receptor NOUN B-O
as ADP B-O
a DET B-O
PGE2 PROPN B-AC
receptor NOUN B-O
, PUNCT B-O
same ADJ B-O
as ADP B-O
the DET B-O
other ADJ B-O
types NOUN B-O
of ADP B-O
EP PROPN B-O
receptor NOUN B-O
( PUNCT B-O
EP1 NOUN B-O
- PUNCT B-O
2 NUM B-O
and CCONJ B-O
EP4 PROPN B-O
) PUNCT B-O
, PUNCT B-O
is AUX B-O
a DET B-O
G PROPN B-LF
- PUNCT I-LF
protein NOUN I-LF
- PUNCT I-LF
coupled VERB I-LF
receptor NOUN I-LF
( PUNCT B-O
GPCR PROPN B-AC
) PUNCT B-O
[ X B-O
23 NUM B-O
] PUNCT B-O
and CCONJ B-O
specifically ADV B-O
contributes VERB B-O
to ADP B-O
the DET B-O
cough NOUN B-O
through ADP B-O
activating VERB B-O
airway NOUN B-O
sensory ADJ B-O
nerves NOUN B-O
[ X B-O
24 NUM B-O
, PUNCT B-O
25 NUM B-O
] PUNCT B-O
. PUNCT B-O

G6PD PROPN B-AC
, PUNCT B-O
glucose-6 NOUN B-LF
- PUNCT I-LF
phosphate NOUN I-LF
dehydrogenase NOUN I-LF
. PUNCT B-O

Partial ADJ B-LF
least ADJ I-LF
squares NOUN I-LF
regression NOUN I-LF
( PUNCT B-O
PLSR PROPN B-AC
) PUNCT B-O
, PUNCT B-O
a DET B-O
technique NOUN B-O
previously ADV B-O
shown VERB B-O
to ADP B-O
be AUX B-O
useful ADJ B-O
for ADP B-O
the DET B-O
creation NOUN B-O
of ADP B-O
signal NOUN B-O
– PUNCT B-O
response NOUN B-O
models NOUN B-O
based VERB B-O
on ADP B-O
highly ADV B-O
dimensional ADJ B-O
datasets NOUN B-O
, PUNCT B-O
was AUX B-O
used VERB B-O
to ADP B-O
correlate VERB B-O
phosphorylation NOUN B-O
events NOUN B-O
to ADP B-O
both CCONJ B-O
migration NOUN B-O
and CCONJ B-O
proliferation NOUN B-O
[ PUNCT B-O
10 NUM B-O
] PUNCT B-O
. PUNCT B-O

Copper NOUN B-LF
( PUNCT B-O
Cu PROPN B-AC
) PUNCT B-O
and CCONJ B-O
zinc NOUN B-LF
( PUNCT B-O
Zn PROPN B-AC
) PUNCT B-O
are AUX B-O
essential ADJ B-O
nutritional ADJ B-O
metals NOUN B-O
required VERB B-O
for ADP B-O
the DET B-O
function NOUN B-O
of ADP B-O
numerous ADJ B-O
enzymatic ADJ B-O
molecules NOUN B-O
active ADJ B-O
in ADP B-O
human ADJ B-O
cell NOUN B-O
metabolic ADJ B-O
pathways NOUN B-O
. PUNCT B-O

RNase NOUN B-O
T NOUN B-O
showed VERB B-O
in ADP B-O
in ADP B-O
vitro ADJ B-O
experiments NOUN B-O
that SCONJ B-O
it PRON B-O
can AUX B-O
serve VERB B-O
as ADP B-O
a DET B-O
downstream ADJ B-O
exonuclease NOUN B-O
of ADP B-O
Endonuclease NOUN B-LF
V NOUN I-LF
( PUNCT B-O
alternative ADJ B-LF
EndoV)–mediated PROPN B-AC
base NOUN I-LF
excision NOUN I-LF
repair NOUN I-LF
( PUNCT B-O
AER PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
33 NUM B-O
] PUNCT B-O
. PUNCT B-O

Interestingly ADV B-O
, PUNCT B-O
incubation NOUN B-O
of ADP B-O
parasites NOUN B-O
in ADP B-O
the DET B-O
presence NOUN B-O
of ADP B-O
0.5 NUM B-O
μM NOUN B-O
Cytochalasin NOUN B-LF
D PROPN I-LF
( PUNCT B-O
CD PROPN B-AC
; PUNCT B-O
a DET B-O
drug NOUN B-O
used VERB B-O
to PART B-O
disrupt VERB B-O
F NOUN B-O
- ADJ B-O
actin NOUN B-O
) PUNCT B-O
did AUX B-O
not PART B-O
result VERB B-O
in ADP B-O
significant ADJ B-O
reduction NOUN B-O
of ADP B-O
bead NOUN B-O
translocation NOUN B-O
( PUNCT B-O
Fig NOUN B-O
1 NUM B-O
G NOUN B-O
) PUNCT B-O
, PUNCT B-O
confirming VERB B-O
that SCONJ B-O
retrograde ADJ B-O
membrane NOUN B-O
flow NOUN B-O
can AUX B-O
occur VERB B-O
in ADP B-O
the DET B-O
absence NOUN B-O
of ADP B-O
a DET B-O
functional ADJ B-O
acto NOUN B-O
- ADJ B-O
myosin NOUN B-O
system NOUN B-O
, PUNCT B-O
as SCONJ B-O
reported VERB B-O
previously ADV B-O
[ X B-O
5 NUM B-O
] PUNCT B-O
. PUNCT B-O

Focal ADJ B-O
increases NOUN B-O
in ADP B-O
fMRI PROPN B-AC
- PUNCT B-O
activity NOUN B-O
were AUX B-O
observed VERB B-O
in ADP B-O
area NOUN B-O
AIP PROPN B-AC
, PUNCT B-O
consisting VERB B-O
of ADP B-O
both DET B-O
aAIP PROPN B-AC
and CCONJ B-O
pAIP PROPN B-AC
( PUNCT B-O
Fig NOUN B-O
. PUNCT B-O

2A NUM B-O
, PUNCT B-O
left ADJ B-O
column NOUN B-O
, PUNCT B-O
first ADJ B-O
and CCONJ B-O
second ADJ B-O
row NOUN B-O
) PUNCT B-O
, PUNCT B-O
in ADP B-O
the DET B-O
anterior ADJ B-O
lateral ADJ B-O
bank NOUN B-O
of ADP B-O
the DET B-O
IPS PROPN B-AC
. PUNCT B-O

Furthermore ADV B-O
, PUNCT B-O
aAIP PROPN B-AC
- PUNCT B-O
EM PROPN B-AC
elicited VERB B-O
significant ADJ B-O
fMRI PROPN B-AC
activations NOUN B-O
in ADP B-O
the DET B-O
medial ADJ B-O
bank NOUN B-O
of ADP B-O
the DET B-O
IPS PROPN B-AC
( PUNCT B-O
area NOUN B-O
MIP PROPN B-AC
) PUNCT B-O
, PUNCT B-O
in ADP B-O
area NOUN B-O
PFG PROPN B-AC
in ADP B-O
the DET B-O
rostral ADJ B-O
portion NOUN B-O
of ADP B-O
the DET B-O
inferior ADJ B-O
parietal ADJ B-O
lobule NOUN B-O
, PUNCT B-O
in ADP B-O
the DET B-O
most ADV B-O
anterior ADJ B-O
sector NOUN B-O
of ADP B-O
somatosensory ADJ B-O
area NOUN B-O
S2 PROPN B-O
and CCONJ B-O
in ADP B-O
ventral ADJ B-LF
premotor ADJ I-LF
cortex NOUN I-LF
( PUNCT B-O
PMv PROPN B-AC
, PUNCT B-O
or CCONJ B-O
area NOUN B-O
F5 NUM B-O
; PUNCT B-O
Fig NOUN B-O
. PUNCT B-O

2A NUM B-O
, PUNCT B-O
left ADJ B-O
column NOUN B-O
, PUNCT B-O
rows NOUN B-O
2–5 NUM B-O
) PUNCT B-O
. PUNCT B-O

Here ADV B-O
, PUNCT B-O
the DET B-O
high ADJ B-O
level NOUN B-O
of ADP B-O
HR PROPN B-AC
is AUX B-O
due ADJ B-O
to ADP B-O
the DET B-O
programmed VERB B-O
formation NOUN B-O
of ADP B-O
a DET B-O
large ADJ B-O
number NOUN B-O
of ADP B-O
DNA NOUN B-O
double ADJ B-LF
- PUNCT I-LF
strand NOUN I-LF
breaks NOUN I-LF
( PUNCT B-O
DSBs PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
4 NUM B-O
] PUNCT B-O
. PUNCT B-O

Natural ADJ B-LF
killer NOUN I-LF
T PROPN I-LF
( PUNCT B-O
NKT PROPN B-AC
) PUNCT B-O
cell NOUN B-O
development NOUN B-O
depends VERB B-O
on ADP B-O
recognition NOUN B-O
of ADP B-O
self NOUN B-O
- PUNCT B-O
glycolipids NOUN B-O
via ADP B-O
their PRON B-O
semi ADJ B-O
- PUNCT B-O
invariant ADJ B-O
Vα14i NOUN B-O
- PUNCT B-O
TCR PROPN B-O
. PUNCT B-O

However ADV B-O
, PUNCT B-O
to PART B-O
what DET B-O
extent NOUN B-O
TCR PROPN B-O
- PUNCT B-O
mediated VERB B-O
signals NOUN B-O
determine VERB B-O
identity NOUN B-O
and CCONJ B-O
function NOUN B-O
of ADP B-O
mature ADJ B-O
NKT PROPN B-AC
cells NOUN B-O
remains AUX B-O
incompletely ADV B-O
understood VERB B-O
. PUNCT B-O

Inhalation NOUN B-O
injury NOUN B-O
predisposes VERB B-O
these DET B-O
patients NOUN B-O
to ADP B-O
respiratory ADJ B-O
failure NOUN B-O
, PUNCT B-O
acute ADJ B-LF
respiratory ADJ I-LF
distress NOUN I-LF
syndrome NOUN I-LF
( PUNCT B-O
ARDS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
pneumonia NOUN B-O
. PUNCT B-O

In ADP B-O
support NOUN B-O
of ADP B-O
this DET B-O
idea NOUN B-O
we PRON B-O
found VERB B-O
that SCONJ B-O
a DET B-O
bacterially ADV B-O
expressed VERB B-O
p180 NOUN B-O
lysine NOUN B-O
- PUNCT B-O
rich ADJ B-O
region NOUN B-O
, PUNCT B-O
fused VERB B-O
to ADP B-O
glutathione NOUN B-LF
s NOUN I-LF
- PUNCT I-LF
transferase NOUN I-LF
( PUNCT B-O
GST PROPN B-AC
- PUNCT B-O
p180 NOUN B-O
- PUNCT B-O
Lys PROPN B-O
; PUNCT B-O
Figure PROPN B-O
7A NUM B-O
) PUNCT B-O
, PUNCT B-O
could AUX B-O
form VERB B-O
a DET B-O
complex NOUN B-O
with ADP B-O
a DET B-O
32P NOUN B-O
- PUNCT B-O
labeled VERB B-O
RNA NOUN B-O
derived VERB B-O
from ADP B-O
the DET B-O
human ADJ B-O
insulin NOUN B-O
SSCR PROPN B-AC
( PUNCT B-O
Figure PROPN B-O
7B NUM B-O
) PUNCT B-O
. PUNCT B-O

In ADP B-O
contrast NOUN B-O
, PUNCT B-O
no DET B-O
complex NOUN B-O
was AUX B-O
formed VERB B-O
between ADP B-O
this DET B-O
RNA NOUN B-O
and CCONJ B-O
a DET B-O
control NOUN B-O
protein NOUN B-O
, PUNCT B-O
GST PROPN B-AC
- PUNCT B-O
Ran PROPN B-O
( PUNCT B-O
Figure PROPN B-O
7A NUM B-O
– PUNCT B-O
B NOUN B-O
) PUNCT B-O
. PUNCT B-O

By ADP B-O
varying VERB B-O
the DET B-O
amount NOUN B-O
of ADP B-O
protein NOUN B-O
in ADP B-O
our PRON B-O
binding VERB B-O
assay NOUN B-O
, PUNCT B-O
we PRON B-O
estimate VERB B-O
that SCONJ B-O
the DET B-O
GST PROPN B-AC
- PUNCT B-O
p180 NOUN B-O
- PUNCT B-O
Lys PROPN B-O
binds VERB B-O
to ADP B-O
RNA NOUN B-O
with ADP B-O
an DET B-O
affinity NOUN B-O
of ADP B-O
about ADP B-O
0.8 NUM B-O
µM. NOUN B-O
Here ADV B-O
we PRON B-O
report VERB B-O
the DET B-O
modulation NOUN B-O
of ADP B-O
the DET B-O
structure NOUN B-O
/ SYM B-O
function NOUN B-O
of ADP B-O
recombinant ADJ B-O
Ace PROPN B-AC
by ADP B-O
small ADJ B-O
molecule NOUN B-O
calcium NOUN B-LF
- PUNCT I-LF
activated VERB I-LF
chloride NOUN I-LF
channel NOUN I-LF
( PUNCT B-O
CaCC PROPN B-AC
) PUNCT B-O
inhibitors NOUN B-O
, PUNCT B-O
namely ADV B-O
CaCCinh PROPN B-O
- PUNCT B-O
A01 PROPN B-O
, PUNCT B-O
digallic ADJ B-LF
acid NOUN I-LF
( PUNCT B-O
DGA PROPN B-AC
) PUNCT B-O
and CCONJ B-O
tannic NOUN B-O
acid NOUN B-O
. PUNCT B-O

IMD PROPN B-O
, PUNCT B-O
Index PROPN B-O
of ADP B-O
Multiple ADJ B-O
Deprivation NOUN B-O
, PUNCT B-O
derived VERB B-O
from ADP B-O
the DET B-O
Lower PROPN B-O
Super PROPN B-O
Output PROPN B-O
Area PROPN B-O
of ADP B-O
the DET B-O
patient NOUN B-O
’s PART B-O
home NOUN B-O
address NOUN B-O
; PUNCT B-O
IQR PROPN B-AC
, PUNCT B-O
interquartile ADJ B-LF
range NOUN I-LF
. PUNCT B-O

Analyzed VERB B-O
parameter NOUN B-O
were AUX B-O
immunoreactive ADJ B-LF
area NOUN B-O
( PUNCT B-O
IR PROPN B-AC
) PUNCT B-O
in ADP B-O
percent NOUN B-O
of ADP B-O
the DET B-O
ROI NOUN B-O
area NOUN B-O
and CCONJ B-O
summarized VERB B-O
object NOUN B-O
intensity NOUN B-O
in ADP B-O
a.u./mm2 X B-O
. PUNCT B-O

Bovine ADJ B-LF
serum NOUN I-LF
albumin NOUN I-LF
( PUNCT B-O
BSA PROPN B-AC
) PUNCT B-O
medium NOUN B-O
, PUNCT B-O
containing VERB B-O
no DET B-O
peptides NOUN B-O
, PUNCT B-O
was AUX B-O
used VERB B-O
as ADP B-O
a DET B-O
negative ADJ B-O
control NOUN B-O
. PUNCT B-O

Recently ADV B-O
, PUNCT B-O
it PRON B-O
has AUX B-O
been AUX B-O
shown VERB B-O
that PRON B-O
PD-L1 PROPN B-AC
intracytoplasmic ADJ B-O
tail NOUN B-O
can AUX B-O
trigger VERB B-O
a DET B-O
signal NOUN B-O
cascade NOUN B-O
that PRON B-O
make VERB B-O
cancer NOUN B-O
cells NOUN B-O
resistant ADJ B-O
to ADP B-O
interferon NOUN B-LF
( PUNCT B-O
IFN)-mediated PROPN B-AC
cytotoxicity NOUN B-O
through ADP B-O
a DET B-O
STAT3 NOUN B-O
/ SYM B-O
caspase-7 NOUN B-O
- PUNCT B-O
dependent ADJ B-O
pathway NOUN B-O
[ PUNCT B-O
16 NUM B-O
] PUNCT B-O
. PUNCT B-O

Their PRON B-O
transcripts NOUN B-O
were AUX B-O
generally ADV B-O
classified VERB B-O
into ADP B-O
two NUM B-O
groups NOUN B-O
including VERB B-O
long ADJ B-O
non ADJ B-O
- ADJ B-O
coding ADJ B-O
RNAs NOUN B-O
( PUNCT B-O
longer ADJ B-O
than ADP B-O
200 NUM B-O
nt NOUN B-O
) PUNCT B-O
and CCONJ B-O
small ADJ B-LF
RNAs NOUN I-LF
( PUNCT B-O
sRNAs PROPN B-AC
, PUNCT B-O
shorter ADJ B-O
than ADP B-O
200 NUM B-O
nt NOUN B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
underlying VERB B-O
data NOUN B-O
can AUX B-O
be AUX B-O
found VERB B-O
in ADP B-O
S1 PROPN B-O
Data PROPN B-O
. PUNCT B-O

; PUNCT B-O
eFSGM PROPN B-AC
, PUNCT B-O
extended ADJ B-LF
FSGM PROPN I-LF
FSGM PROPN B-AC
; PUNCT B-O
FBA PROPN B-AC
, PUNCT B-O
feature NOUN B-LF
- PUNCT I-LF
based VERB I-LF
attention NOUN I-LF
; PUNCT B-O
HR PROPN B-AC
, PUNCT B-O
hit NOUN B-LF
rate NOUN I-LF
; PUNCT B-O
RT PROPN B-AC
, PUNCT B-O
reaction NOUN B-LF
time NOUN I-LF
. PUNCT B-O

Results NOUN B-O
of ADP B-O
logistic ADJ B-O
regression NOUN B-O
models NOUN B-O
are AUX B-O
presented VERB B-O
using VERB B-O
adjusted ADJ B-LF
Odds NOUN I-LF
Ratio PROPN I-LF
( PUNCT B-O
aOR PROPN B-AC
) PUNCT B-O
and CCONJ B-O
95 NUM B-LF
% NOUN I-LF
Confidence PROPN I-LF
Interval NOUN I-LF
( PUNCT B-O
95 PROPN B-AC
) PUNCT B-O
. PUNCT B-O

To PART B-O
handle VERB B-O
missing VERB B-O
data NOUN B-O
of ADP B-O
two NUM B-O
covariates NOUN B-O
, PUNCT B-O
multivariate ADJ B-O
logistic ADJ B-O
regression NOUN B-O
models NOUN B-O
were AUX B-O
performed VERB B-O
using VERB B-O
multiple ADJ B-O
imputation NOUN B-O
[ X B-O
45,46 NUM B-O
] PUNCT B-O
. PUNCT B-O

F NOUN B-O
- PUNCT B-O
actin NOUN B-O
induction NOUN B-O
was AUX B-O
plotted VERB B-O
as ADP B-O
mean NOUN B-O
± SYM B-O
standard ADJ B-O
error NOUN B-O
of ADP B-O
the DET B-O
mean NOUN B-O
( PUNCT B-O
SEM PROPN B-O
) PUNCT B-O
. PUNCT B-O

n NOUN B-O
= SYM B-O
3 NUM B-O
. PUNCT B-O

* PUNCT B-O
p NOUN B-O
≤ PUNCT B-O
0.05 NUM B-O
, PUNCT B-O
* PUNCT B-O
* PUNCT B-O
* PUNCT B-O
p NOUN B-O
≤ PUNCT B-O
0.001 NUM B-O
. PUNCT B-O

( PUNCT B-O
D X B-O
) PUNCT B-O
Time NOUN B-O
- PUNCT B-O
lapse NOUN B-O
total ADJ B-LF
internal ADJ I-LF
reflection NOUN I-LF
fluorescence NOUN I-LF
microscopy NOUN I-LF
( PUNCT B-O
TIRFM PROPN B-AC
) PUNCT B-O
of ADP B-O
speckle NOUN B-O
mCherry NOUN B-O
- PUNCT B-O
β PUNCT B-O
- PUNCT B-O
actin NOUN B-O
in ADP B-O
eNOS PROPN B-AC
and CCONJ B-O
G2A NOUN B-O
T NOUN B-O
cells NOUN B-O
, PUNCT B-O
stimulated VERB B-O
on ADP B-O
CD3 PROPN B-O
Ab PROPN B-O
- PUNCT B-O
coated VERB B-O
chambers NOUN B-O
. PUNCT B-O

Free ADJ B-O
fatty ADJ B-LF
acid NOUN I-LF
( PUNCT B-O
FA PROPN B-AC
) PUNCT B-O
and CCONJ B-O
polar ADJ B-O
lipid NOUN B-O
species NOUN B-O
were AUX B-O
determined VERB B-O
in ADP B-O
flowers NOUN B-O
and CCONJ B-O
caulinary ADJ B-O
leaves NOUN B-O
of ADP B-O
7 NUM B-O
- PUNCT B-O
week NOUN B-O
- PUNCT B-O
old ADJ B-O
, PUNCT B-O
mature ADJ B-O
flowering VERB B-O
plants NOUN B-O
. PUNCT B-O

The DET B-O
substances NOUN B-O
which PRON B-O
mainly ADV B-O
contributed VERB B-O
to ADP B-O
Ozone PROPN B-LF
layer NOUN I-LF
depletion NOUN I-LF
( PUNCT B-O
OLD PROPN B-AC
) PUNCT B-O
were AUX B-O
Methane PROPN B-O
, PUNCT B-O
bromotrifluoro- NOUN B-O
, PUNCT B-O
Halon PROPN B-O
1301 NUM B-O
( PUNCT B-O
7.16E-06 NUM B-O
kg NOUN B-O
CFC-11 NOUN B-O
eq NOUN B-O
) PUNCT B-O
and CCONJ B-O
Methane PROPN B-O
, PUNCT B-O
trichlorofluoro NOUN B-O
CFC-11 NOUN B-O
( PUNCT B-O
7.28559E-11 NUM B-O
kg NOUN B-O
CFC-11 NOUN B-O
eq NOUN B-O
) PUNCT B-O
. PUNCT B-O

There PRON B-O
is VERB B-O
an DET B-O
increasing VERB B-O
expectation NOUN B-O
that SCONJ B-O
CHWs PROPN B-AC
will AUX B-O
participate VERB B-O
in ADP B-O
disease NOUN B-O
surveillance NOUN B-O
and CCONJ B-O
data NOUN B-O
collection NOUN B-O
, PUNCT B-O
diagnosis NOUN B-O
and CCONJ B-O
referral NOUN B-O
for ADP B-O
care NOUN B-O
, PUNCT B-O
and CCONJ B-O
antiretroviral ADJ B-LF
therapy NOUN I-LF
( PUNCT B-O
ART PROPN B-AC
) PUNCT B-O
provision NOUN B-O
[ PUNCT B-O
10 NUM B-O
] PUNCT B-O
. PUNCT B-O

( PUNCT B-O
A X B-O
) PUNCT B-O
Trimethoprim NOUN B-O
+ SYM B-O
sulfamethizole NOUN B-O
. PUNCT B-O

( PUNCT B-O
B X B-O
) PUNCT B-O
Trimethoprim NOUN B-O
+ SYM B-O
AZT PROPN B-AC
. PUNCT B-O

Synergistic ADJ B-O
fractional ADJ B-LF
inhibitory ADJ I-LF
concentration NOUN I-LF
index NOUN I-LF
( PUNCT B-O
FICI PROPN B-AC
) PUNCT B-O
values NOUN B-O
( PUNCT B-O
≤0.5 NUM B-O
) PUNCT B-O
are AUX B-O
marked VERB B-O
with ADP B-O
yellow ADJ B-O
bars NOUN B-O
, PUNCT B-O
and CCONJ B-O
nonsynergistic ADJ B-O
( PUNCT B-O
FICI PROPN B-AC
> SYM B-O
0.5 NUM B-O
) PUNCT B-O
FICI PROPN B-AC
values NOUN B-O
are AUX B-O
marked VERB B-O
with ADP B-O
blue ADJ B-O
bars NOUN B-O
. PUNCT B-O

However ADV B-O
, PUNCT B-O
Zbtb7a NOUN B-O
is AUX B-O
not PART B-O
restricted VERB B-O
to PART B-O
NFκB PROPN B-AC
target NOUN B-O
promoters NOUN B-O
, PUNCT B-O
and CCONJ B-O
indeed ADV B-O
, PUNCT B-O
a DET B-O
large ADJ B-O
fraction NOUN B-O
of ADP B-O
all DET B-O
genomic ADJ B-O
promoters NOUN B-O
are AUX B-O
associated VERB B-O
with ADP B-O
overlapping VERB B-O
— PUNCT B-O
or CCONJ B-O
nearby ADJ B-O
— PUNCT B-O
Zbtb7a NOUN B-O
binding NOUN B-O
( PUNCT B-O
up ADP B-O
to PART B-O
17 NUM B-O
% PUNCT B-O
or CCONJ B-O
41 NUM B-O
% PUNCT B-O
, PUNCT B-O
respectively ADV B-O
, PUNCT B-O
of ADP B-O
all DET B-O
promoters NOUN B-O
in ADP B-O
fibroblasts NOUN B-O
; PUNCT B-O
Fig PROPN B-O
2D NUM B-O
) PUNCT B-O
, PUNCT B-O
with ADP B-O
a DET B-O
preference NOUN B-O
for ADP B-O
guanine NOUN B-LF
- PUNCT I-LF
cytosine NOUN I-LF
( PUNCT B-O
GC)-rich PROPN B-AC
and CCONJ B-O
CpG NOUN B-LF
island NOUN I-LF
( PUNCT B-O
CGI)-containing PROPN B-AC
promoters NOUN B-O
( PUNCT B-O
S2H PROPN B-O
and CCONJ B-O
S2I PROPN B-O
Fig PROPN B-O
) PUNCT B-O
. PUNCT B-O

LUSC PROPN B-AC
( PUNCT B-O
lung NOUN B-LF
squamous ADJ I-LF
cell NOUN I-LF
carcinoma NOUN I-LF
) PUNCT B-O
Based VERB B-O
on ADP B-O
observations NOUN B-O
in ADP B-O
Drosophila PROPN B-O
[ PUNCT B-O
5 NUM B-O
] PUNCT B-O
, PUNCT B-O
we PRON B-O
set VERB B-O
out ADP B-O
to PART B-O
assess VERB B-O
the DET B-O
role NOUN B-O
of ADP B-O
stress NOUN B-O
- PUNCT B-O
response NOUN B-O
pathways NOUN B-O
, PUNCT B-O
particularly ADV B-O
of ADP B-O
heat NOUN B-LF
shock NOUN I-LF
protein NOUN I-LF
90 NUM I-LF
( PUNCT B-O
Hsp90 PROPN B-AC
) PUNCT B-O
function NOUN B-O
, PUNCT B-O
in ADP B-O
phenotype NOUN B-O
modification NOUN B-O
, PUNCT B-O
using VERB B-O
zebrafish NOUN B-O
as ADP B-O
a DET B-O
vertebrate ADJ B-O
model NOUN B-O
. PUNCT B-O

Driving VERB B-LF
simulator NOUN I-LF
( PUNCT B-O
DS PROPN B-AC
) PUNCT B-O
systems NOUN B-O
have VERB B-O
advantages NOUN B-O
in ADP B-O
controlling VERB B-O
traffic- NOUN B-O
and CCONJ B-O
automobile NOUN B-O
- PUNCT B-O
related VERB B-O
conditions NOUN B-O
[ PUNCT B-O
1,13,14 NUM B-O
] PUNCT B-O
. PUNCT B-O

We PRON B-O
assumed VERB B-O
a DET B-O
50 NUM B-O
% NOUN B-O
proportion NOUN B-O
, PUNCT B-O
80 NUM B-O
% NOUN B-O
power NOUN B-O
, PUNCT B-O
95 NUM B-O
% NOUN B-O
confidence NOUN B-LF
interval NOUN I-LF
( PUNCT B-O
CI PROPN B-AC
) PUNCT B-O
and CCONJ B-O
5 NUM B-O
% NOUN B-O
precision NOUN B-O
. PUNCT B-O

All DET B-O
known VERB B-O
AP PROPN B-AC
endonucleases NOUN B-O
are AUX B-O
grouped VERB B-O
in ADP B-O
two NUM B-O
distinct ADJ B-O
superfamilies NOUN B-O
based VERB B-O
on ADP B-O
their PRON B-O
structural ADJ B-O
and CCONJ B-O
sequence NOUN B-O
similarity NOUN B-O
to ADP B-O
either CCONJ B-O
Escherichia PROPN B-LF
coli PROPN I-LF
exonuclease NOUN I-LF
III NUM I-LF
( PUNCT B-O
Xth PROPN B-AC
; PUNCT B-O
Endonuclease NOUN B-LF
— PUNCT I-LF
Exonuclease NOUN I-LF
— PUNCT I-LF
Phosphatase NOUN I-LF
superfamily NOUN B-O
, PUNCT B-O
or CCONJ B-O
EEP PROPN B-AC
) PUNCT B-O
or CCONJ B-O
endonuclease NOUN B-O
IV NUM B-O
( PUNCT B-O
Nfo PROPN B-O
) PUNCT B-O
[ PUNCT B-O
10 NUM B-O
] PUNCT B-O
. PUNCT B-O

Arm PROPN B-AC
, PUNCT B-O
Armadillo PROPN B-LF
; PUNCT B-O
bGal PROPN B-AC
, PUNCT B-O
beta NOUN B-LF
- PUNCT I-LF
galactosidase NOUN I-LF
; PUNCT B-O
Cyt PROPN B-AC
-Arm PROPN B-AC
, PUNCT B-O
Cytoplasm NOUN B-O
- PUNCT B-O
Armadillo PROPN B-LF
; PUNCT B-O
GBSC PROPN B-AC
, PUNCT B-O
glioblastoma NOUN B-LF
multiforme ADJ I-LF
stem NOUN I-LF
- PUNCT I-LF
like ADJ I-LF
cell NOUN I-LF
; PUNCT B-O
GFP PROPN B-AC
, PUNCT B-O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT B-O
igl PROPN B-AC
, PUNCT B-O
igloo NOUN B-LF
; PUNCT B-O
myrRFP PROPN B-O
, PUNCT B-O
myristoilated PROPN B-O
Red PROPN B-O
Fluorescent PROPN B-O
Protein PROPN B-O
; PUNCT B-O
nkd PROPN B-AC
, PUNCT B-O
-lacZnkd PROPN B-AC
, PUNCT B-O
transcriptional ADJ B-O
beta NOUN B-LF
- PUNCT I-LF
galactosidase NOUN I-LF
reporter NOUN B-O
of ADP B-O
naked ADJ B-O
gene NOUN B-O
NLGN3 PROPN B-O
; PUNCT B-O
NMRI PROPN B-O
, PUNCT B-O
Naval PROPN B-O
Medical PROPN B-O
Research PROPN B-O
Institute PROPN B-O
. PUNCT B-O

Very ADV B-LF
- PUNCT I-LF
long ADV I-LF
- PUNCT I-LF
chain NOUN I-LF
fatty ADJ I-LF
acid NOUN I-LF
( PUNCT B-O
VLCFA PROPN B-AC
) PUNCT B-O
accumulation NOUN B-O
has AUX B-O
long ADV B-O
been AUX B-O
suggested VERB B-O
as ADP B-O
a DET B-O
major ADJ B-O
disease NOUN B-O
- PUNCT B-O
mediating VERB B-O
factor NOUN B-O
, PUNCT B-O
although SCONJ B-O
the DET B-O
exact ADJ B-O
pathological ADJ B-O
consequences NOUN B-O
are AUX B-O
unclear ADJ B-O
. PUNCT B-O

Unexpectedly ADV B-O
, PUNCT B-O
we PRON B-O
found VERB B-O
that SCONJ B-O
Notch1 NOUN B-O
- PUNCT B-O
expressing VERB B-O
cells NOUN B-O
invariably ADV B-O
lacked VERB B-O
the DET B-O
expression NOUN B-O
of ADP B-O
ERα PROPN B-AC
and CCONJ B-O
PR PROPN B-AC
( PUNCT B-O
Fig PROPN B-O
. PUNCT B-O

2F NUM B-O
, PUNCT B-O
G NOUN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
we PRON B-O
confirmed VERB B-O
these DET B-O
results NOUN B-O
by ADP B-O
quantitative ADJ B-LF
Real ADJ I-LF
Time NOUN I-LF
Polymerase PROPN I-LF
Chain PROPN I-LF
Reaction PROPN I-LF
( PUNCT B-O
qRT PROPN B-AC
) PUNCT B-O
in ADP B-O
sorted ADJ B-O
-PCRGFP PROPN B-AC
- PUNCT B-O
labeled VERB B-O
cells NOUN B-O
( PUNCT B-O
S3B PROPN B-O
, PUNCT B-O
C PROPN B-O
Fig PROPN B-O
. PUNCT B-O

) PUNCT B-O
. PUNCT B-O

In ADP B-O
RSV PROPN B-AC
infected VERB B-O
animals NOUN B-O
treated VERB B-O
with ADP B-O
EGY-2 PROPN B-AC
, PUNCT B-O
alveolar ADJ B-LF
macrophages NOUN I-LF
( PUNCT B-O
AM PROPN B-AC
) PUNCT B-O
in ADP B-O
the DET B-O
high ADJ B-O
dose NOUN B-O
group NOUN B-O
showed VERB B-O
a DET B-O
markedly ADV B-O
enhanced VERB B-O
phagocytic ADJ B-O
function NOUN B-O
at ADP B-O
the DET B-O
early ADJ B-O
phase NOUN B-O
of ADP B-O
infection NOUN B-O
, PUNCT B-O
as ADP B-O
both CCONJ B-O
the DET B-O
number NOUN B-O
of ADP B-O
phagocytic ADJ B-O
AM PROPN B-AC
as ADP B-O
well ADV B-O
as ADP B-O
their PRON B-O
phagocytic ADJ B-O
activity NOUN B-O
was AUX B-O
significantly ADV B-O
enhanced VERB B-O
compared VERB B-O
to ADP B-O
untreated ADJ B-O
animals NOUN B-O
on ADP B-O
day NOUN B-O
1 NUM B-O
p.i PROPN B-AC
. PUNCT B-O

( PUNCT B-O
Fig NOUN B-O
4A NUM B-O
and CCONJ B-O
4B NOUN B-O
, PUNCT B-O
respectively ADV B-O
) PUNCT B-O
. PUNCT B-O

Finally ADV B-O
, PUNCT B-O
as ADP B-O
a DET B-O
sensitivity NOUN B-O
analysis NOUN B-O
, PUNCT B-O
we PRON B-O
constructed VERB B-O
five NUM B-O
different ADJ B-O
genetic ADJ B-LF
pigmentation NOUN I-LF
scores NOUN I-LF
, PUNCT B-O
one NUM B-O
for ADP B-O
each DET B-O
pigmentation NOUN B-O
trait NOUN B-O
( PUNCT B-O
eye NOUN B-O
color NOUN B-O
, PUNCT B-O
hair NOUN B-O
color NOUN B-O
, PUNCT B-O
skin NOUN B-O
phototype NOUN B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
presence NOUN B-O
of ADP B-O
freckles NOUN B-O
and CCONJ B-O
tanning NOUN B-O
) PUNCT B-O
, PUNCT B-O
from ADP B-O
our PRON B-O
data NOUN B-O
( PUNCT B-O
S2 PROPN B-O
Table PROPN B-O
) PUNCT B-O
we PRON B-O
analyzed VERB B-O
their PRON B-O
relationship NOUN B-O
with ADP B-O
cancer NOUN B-O
in ADP B-O
the DET B-O
same ADJ B-O
way NOUN B-O
we PRON B-O
have AUX B-O
described VERB B-O
for ADP B-O
the DET B-O
GPS PROPN B-AC
. PUNCT B-O

SDQ PROPN B-AC
, PUNCT B-O
Strengths NOUN B-LF
and CCONJ I-LF
Difficulties NOUN I-LF
Questionnaire NOUN I-LF
. PUNCT B-O

In ADP B-O
Drosophila PROPN B-O
, PUNCT B-O
the DET B-O
family NOUN B-O
of ADP B-O
gustatory ADJ B-LF
receptors NOUN I-LF
( PUNCT B-O
Grs PROPN B-AC
) PUNCT B-O
is AUX B-O
predicted VERB B-O
to PART B-O
consist VERB B-O
of ADP B-O
68 NUM B-O
genes NOUN B-O
[ PUNCT B-O
4],[5 NUM B-O
] PUNCT B-O
. PUNCT B-O

DIC PROPN B-AC
, PUNCT B-O
differential ADJ B-LF
interference NOUN I-LF
contrast NOUN I-LF
; PUNCT B-O
SM PROPN B-O
, PUNCT B-O
Sperm NOUN B-O
Medium NOUN B-O
. PUNCT B-O

In ADP B-O
October PROPN B-O
2018 NUM B-O
, PUNCT B-O
we PRON B-O
published VERB B-O
a DET B-O
systematic ADJ B-O
review NOUN B-O
of ADP B-O
clinical ADJ B-LF
practice NOUN I-LF
guidelines NOUN I-LF
( PUNCT B-O
CPG PROPN B-AC
) PUNCT B-O
that PRON B-O
provide VERB B-O
recommendations NOUN B-O
for ADP B-O
the DET B-O
care NOUN B-O
and CCONJ B-O
prevention NOUN B-O
of ADP B-O
adverse ADJ B-O
events NOUN B-O
associated VERB B-O
with ADP B-O
vascular ADJ B-O
catheter NOUN B-O
in ADP B-O
adults NOUN B-O
. PUNCT B-O

Aptima PROPN B-LF
HIV-1 NOUN I-LF
Aptima PROPN B-AC
Quant NOUN I-LF
Dx NOUN I-LF
assay NOUN I-LF
Equation NOUN B-O
2 NUM B-O
: PUNCT B-O
Where SCONJ B-O
RMSE PROPN B-AC
is AUX B-O
root NOUN B-LF
mean ADJ I-LF
square ADJ I-LF
error NOUN I-LF
, PUNCT B-O
Yi PROPN B-O
is AUX B-O
ANN PROPN B-AC
predicted VERB B-O
values NOUN B-O
; PUNCT B-O
yi PROPN B-O
is AUX B-O
experimental ADJ B-O
values NOUN B-O
; PUNCT B-O
n NOUN B-O
is AUX B-O
number NOUN B-O
of ADP B-O
predictions NOUN B-O
. PUNCT B-O

Various ADJ B-O
platforms NOUN B-O
, PUNCT B-O
such ADJ B-O
as ADP B-O
IHC PROPN B-AC
, PUNCT B-O
SS PROPN B-AC
, PUNCT B-O
pyrosequencing NOUN B-LF
( PUNCT B-O
PS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
HRM PROPN B-AC
, PUNCT B-O
are AUX B-O
available ADJ B-O
to PART B-O
analyze VERB B-O
genetic ADJ B-O
mutation NOUN B-O
profiles NOUN B-O
in ADP B-O
clinical ADJ B-O
tissue NOUN B-O
samples NOUN B-O
. PUNCT B-O

One NUM B-O
compound NOUN B-O
seemed VERB B-O
a DET B-O
particularly ADV B-O
promising ADJ B-O
candidate NOUN B-O
for ADP B-O
this DET B-O
sort NOUN B-O
of ADP B-O
approach NOUN B-O
: PUNCT B-O
thiabendazole NOUN B-LF
( PUNCT B-O
TBZ PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
has AUX B-O
been AUX B-O
in ADP B-O
clinical ADJ B-O
use NOUN B-O
as ADP B-O
a DET B-O
systemic ADJ B-O
antifungal ADJ B-O
and CCONJ B-O
deworming NOUN B-O
treatment NOUN B-O
for ADP B-O
40 NUM B-O
years NOUN B-O
. PUNCT B-O

Though SCONJ B-O
long ADJ B-O
endemic ADJ B-O
in ADP B-O
the DET B-O
southeastern ADJ B-O
U.S. PROPN B-O
, PUNCT B-O
raccoon NOUN B-O
rabies NOUN B-O
expanded VERB B-O
rapidly ADV B-O
along ADP B-O
the DET B-O
eastern ADJ B-O
seaboard NOUN B-O
during ADP B-O
the DET B-O
1980s NOUN B-O
and CCONJ B-O
1990s NOUN B-O
from ADP B-O
an DET B-O
initial ADJ B-O
focus NOUN B-O
along ADP B-O
the DET B-O
West PROPN B-O
Virginia PROPN B-O
– PUNCT B-O
Virginia PROPN B-O
border NOUN B-O
; PUNCT B-O
the DET B-O
initial ADJ B-O
focus NOUN B-O
was AUX B-O
linked VERB B-O
to ADP B-O
the DET B-O
long ADJ B-LF
- PUNCT I-LF
distance NOUN I-LF
translocation NOUN I-LF
( PUNCT B-O
LDT PROPN B-AC
) PUNCT B-O
of ADP B-O
rabid ADJ B-O
animals NOUN B-O
from ADP B-O
Florida PROPN B-O
[ PUNCT B-O
5 NUM B-O
] PUNCT B-O
. PUNCT B-O

( PUNCT B-O
A X B-O
) PUNCT B-O
Two NUM B-O
- PUNCT B-O
dimensional ADJ B-O
representation NOUN B-O
of ADP B-O
the DET B-O
mTufA PROPN B-AC
5′ NUM B-O
UTR NOUN B-O
. PUNCT B-O

The DET B-O
RNAfold ADJ B-O
algorithm NOUN B-O
predicted VERB B-O
three NUM B-O
structured VERB B-LF
regions NOUN I-LF
: PUNCT B-O
SR PROPN B-AC
I NOUN B-O
( PUNCT B-O
pink NOUN B-O
) PUNCT B-O
, PUNCT B-O
SR PROPN B-AC
II PROPN B-O
( PUNCT B-O
violet ADJ B-O
) PUNCT B-O
, PUNCT B-O
SR PROPN B-AC
IIIa NOUN B-O
( PUNCT B-O
yellow ADJ B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
SR PROPN B-AC
IIIb NOUN B-O
( PUNCT B-O
green NOUN B-O
) PUNCT B-O
. PUNCT B-O

However ADV B-O
, PUNCT B-O
in ADP B-O
some DET B-O
studies NOUN B-O
, PUNCT B-O
we PRON B-O
investigated VERB B-O
the DET B-O
effects NOUN B-O
of ADP B-O
gp120 NOUN B-O
on ADP B-O
MDDC PROPN B-AC
that PRON B-O
were AUX B-O
simultaneously ADV B-O
induced VERB B-O
to PART B-O
mature VERB B-O
by ADP B-O
other ADJ B-O
stimuli NOUN B-O
, PUNCT B-O
notably ADV B-O
lipopolysaccharide NOUN B-LF
( PUNCT B-O
LPS PROPN B-AC
) PUNCT B-O
. PUNCT B-O

The DET B-O
red ADJ B-O
dots NOUN B-O
represents VERB B-O
LCI PROPN B-AC
, PUNCT B-O
the DET B-O
bright ADJ B-O
yellow ADJ B-O
rectangle NOUN B-O
represents VERB B-O
RV PROPN B-AC
, PUNCT B-O
and CCONJ B-O
the DET B-O
black ADJ B-O
triangle NOUN B-O
represents VERB B-O
the DET B-O
/TLCnLCI PROPN B-AC
. PUNCT B-O

LCI PROPN B-AC
: PUNCT B-O
lung NOUN B-LF
clearance NOUN I-LF
index NOUN I-LF
; PUNCT B-O
RV PROPN B-AC
: PUNCT B-O
the DET B-LF
ratio NOUN I-LF
of ADP I-LF
residual ADJ I-LF
volume NOUN I-LF
to ADP I-LF
total ADJ I-LF
lung NOUN I-LF
capacity NOUN I-LF
; PUNCT B-O
/TLCnLCI PROPN B-AC
: PUNCT B-O
normalized ADJ B-LF
lung NOUN B-LF
clearance NOUN I-LF
index NOUN I-LF
. PUNCT B-O

The DET B-O
drug NOUN B-LF
utilisation NOUN I-LF
( PUNCT B-O
DU PROPN B-AC
) PUNCT B-O
90 NUM B-O
% NOUN B-O
methodology NOUN B-O
was AUX B-O
used VERB B-O
to PART B-O
present VERB B-O
the DET B-O
antibiotics NOUN B-O
accounting VERB B-O
for ADP B-O
90 NUM B-O
% NOUN B-O
of ADP B-O
all DET B-O
antibiotics NOUN B-O
prescribed VERB B-O
[ PUNCT B-O
19 NUM B-O
] PUNCT B-O
. PUNCT B-O

AC PROPN B-AC
and CCONJ B-O
CaM PROPN B-AC
peptides NOUN B-O
were AUX B-O
separated VERB B-O
over ADP B-O
an DET B-O
8 NUM B-O
- PUNCT B-O
min NOUN B-O
gradient NOUN B-O
of ADP B-O
5%–40 NUM B-O
% NOUN B-O
acetonitrile NOUN B-LF
( PUNCT B-O
ACN PROPN B-AC
) PUNCT B-O
at ADP B-O
40 NUM B-O
μL NOUN B-O
/ SYM B-O
min NOUN B-O
and CCONJ B-O
at ADP B-O
0 NUM B-O
° NOUN B-O
C NOUN B-O
. PUNCT B-O

In ADP B-O
this DET B-O
regard NOUN B-O
, PUNCT B-O
the DET B-O
concept NOUN B-O
of ADP B-O
mild ADJ B-LF
cognitive ADJ I-LF
impairment NOUN I-LF
( PUNCT B-O
MCI PROPN B-AC
) PUNCT B-O
is AUX B-O
interesting ADJ B-O
since SCONJ B-O
it PRON B-O
is AUX B-O
seen VERB B-O
as ADP B-O
a DET B-O
transitional ADJ B-O
zone NOUN B-O
between ADP B-O
normal ADJ B-O
aging NOUN B-O
and CCONJ B-O
dementia NOUN B-O
. PUNCT B-O

The DET B-O
quantity NOUN B-O
ρ PUNCT B-O
is AUX B-O
the DET B-O
atmospheric ADJ B-O
density NOUN B-O
depending VERB B-O
on ADP B-O
altitude NOUN B-O
and CCONJ B-O
temperature NOUN B-LF
We PRON B-O
estimate VERB B-O
the DET B-O
prevalence NOUN B-O
of ADP B-O
both CCONJ B-O
overall ADJ B-O
psychiatric ADJ B-O
disorders NOUN B-O
and CCONJ B-O
specific ADJ B-O
diagnoses NOUN B-O
based VERB B-O
on ADP B-O
the DET B-O
International PROPN B-LF
Classification PROPN I-LF
of ADP I-LF
Diseases PROPN I-LF
( PUNCT B-O
ICD PROPN B-AC
) PUNCT B-O
. PUNCT B-O

We PRON B-O
used VERB B-O
generalized ADJ B-LF
linear ADJ I-LF
model NOUN I-LF
( PUNCT B-O
GLM PROPN B-AC
) PUNCT B-O
estimation NOUN B-O
, PUNCT B-O
which PRON B-O
is AUX B-O
a DET B-O
Maximum PROPN B-O
Likelihood NOUN B-O
generalization NOUN B-O
of ADP B-O
the DET B-O
ordinary ADJ B-O
linear ADJ B-O
regression NOUN B-O
approach NOUN B-O
. PUNCT B-O

This DET B-O
assay NOUN B-O
was AUX B-O
used VERB B-O
to PART B-O
screen NOUN B-O
a DET B-O
genome NOUN B-O
- PUNCT B-O
wide ADJ B-O
long ADJ B-LF
double ADJ I-LF
- PUNCT I-LF
stranded VERB I-LF
RNA NOUN I-LF
( PUNCT B-O
dsRNA PROPN B-AC
) PUNCT B-O
library NOUN B-O
for ADP B-O
modulation NOUN B-O
of ADP B-O
pMAPK PROPN B-AC
levels NOUN B-O
induced VERB B-O
by ADP B-O
RASV12 NOUN B-O
expression NOUN B-O
( PUNCT B-O
Figure NOUN B-O
S1B NOUN B-O
and CCONJ B-O
S1C NOUN B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
results NOUN B-O
from ADP B-O
this DET B-O
primary ADJ B-O
screen NOUN B-O
and CCONJ B-O
all DET B-O
subsequent ADJ B-O
screens NOUN B-O
are AUX B-O
made VERB B-O
available ADJ B-O
online ADV B-O
at ADP B-O
the DET B-O
IRIC PROPN B-O
RNAi PROPN B-AC
database NOUN B-O
( PUNCT B-O
http://www.bioinfo.iric.ca/iricrnai X B-O
) PUNCT B-O
. PUNCT B-O

309 NUM B-O
hit NOUN B-O
genes NOUN B-O
, PUNCT B-O
which PRON B-O
reproducibly ADV B-O
altered VERB B-O
pMAPK PROPN B-AC
signal NOUN B-O
, PUNCT B-O
were AUX B-O
identified VERB B-O
in ADP B-O
the DET B-O
primary ADJ B-O
screen NOUN B-O
( PUNCT B-O
Table NOUN B-O
S1 NUM B-O
) PUNCT B-O
. PUNCT B-O

GLA PROPN B-AC
, PUNCT B-O
grape NOUN B-LF
- PUNCT I-LF
like ADJ I-LF
aggregation NOUN I-LF
. PUNCT B-O

We PRON B-O
carried VERB B-O
out ADP B-O
a DET B-O
prospective ADJ B-O
multicentre ADJ B-O
cohort NOUN B-O
study NOUN B-O
within ADP B-O
the DET B-O
Italian PROPN B-O
Cystic PROPN B-LF
Fibrosis PROPN I-LF
Society PROPN B-O
involving VERB B-O
32 NUM B-O
CF PROPN B-AC
centres NOUN B-O
following VERB B-O
6597 NUM B-O
patients NOUN B-O
. PUNCT B-O

The DET B-O
approach NOUN B-O
relies VERB B-O
on ADP B-O
systematic ADJ B-O
creation NOUN B-O
of ADP B-O
genetically ADV B-O
modified VERB B-O
strains NOUN B-O
using VERB B-O
the DET B-O
synthetic ADJ B-LF
genetic ADJ I-LF
array NOUN I-LF
( PUNCT B-O
SGA PROPN B-AC
) PUNCT B-O
methodology NOUN B-O
[ PUNCT B-O
13],[14],[23 NUM B-O
] PUNCT B-O
, PUNCT B-O
which PRON B-O
is AUX B-O
followed VERB B-O
by ADP B-O
acquisition NOUN B-O
of ADP B-O
fluorescent ADJ B-O
images NOUN B-O
of ADP B-O
all DET B-O
strains NOUN B-O
using VERB B-O
a DET B-O
high ADJ B-O
- PUNCT B-O
throughput NOUN B-O
automated VERB B-O
microscopy NOUN B-O
platform NOUN B-O
. PUNCT B-O

Compared VERB B-O
to ADP B-O
the DET B-O
normal ADJ B-O
lung NOUN B-O
function NOUN B-O
group NOUN B-O
, PUNCT B-O
patients NOUN B-O
with ADP B-O
SAD PROPN B-AC
and CCONJ B-O
without ADP B-O
AL PROPN B-AC
had VERB B-O
lower ADJ B-O
spirometric ADJ B-O
values NOUN B-O
, PUNCT B-O
poorer ADJ B-O
quality NOUN B-O
of ADP B-O
life NOUN B-O
and CCONJ B-O
higher ADJ B-O
levels NOUN B-O
of ADP B-O
C NOUN B-LF
- PUNCT I-LF
reactive ADJ I-LF
protein NOUN I-LF
( PUNCT B-O
CRP PROPN B-AC
) PUNCT B-O
, PUNCT B-O
as ADP B-O
well ADV B-O
as ADP B-O
increased VERB B-O
cardiovascular ADJ B-O
risk NOUN B-O
and CCONJ B-O
more ADJ B-O
vascular ADJ B-O
age NOUN B-O
. PUNCT B-O

Similarly ADV B-O
, PUNCT B-O
1,25 NUM B-O
di NOUN B-O
- NOUN B-O
hydroxy NOUN B-O
vitamin NOUN B-LF
D NOUN I-LF
D PROPN B-AC
can AUX B-O
act VERB B-O
as ADP B-O
a DET B-O
modulator NOUN B-O
of ADP B-O
ERs PROPN B-AC
and CCONJ B-O
activate VERB B-O
the DET B-O
nuclear ADJ B-O
signaling NOUN B-O
of ADP B-O
these DET B-O
ERs PROPN B-AC
in ADP B-O
the DET B-O
colonic ADJ B-O
smooth ADJ B-O
muscles[15 X B-O
] PUNCT B-O
. PUNCT B-O

Ethical ADJ B-O
approval NOUN B-O
was AUX B-O
granted VERB B-O
by ADP B-O
the DET B-O
North PROPN B-O
West PROPN B-O
Greater PROPN B-O
Manchester PROPN B-O
East PROPN B-O
Research PROPN B-O
Ethics PROPN B-O
Committee PROPN B-O
( PUNCT B-O
reference NOUN B-O
18 NUM B-O
/ NUM B-O
NW/0211 NUM B-O
) PUNCT B-O
and CCONJ B-O
the DET B-O
National PROPN B-LF
Health PROPN I-LF
Service PROPN I-LF
( PUNCT B-O
NHS PROPN B-AC
) PUNCT B-O
Health PROPN B-O
Research PROPN B-O
Authority PROPN B-O
( PUNCT B-O
project NOUN B-O
reference NOUN B-O
244772 NUM B-O
) PUNCT B-O
. PUNCT B-O

For ADP B-O
pregnant ADJ B-O
women NOUN B-LF
living VERB I-LF
with ADP I-LF
HIV PROPN I-LF
HIV PROPN B-AC
( PUNCT B-O
WLHIV PROPN B-AC
) PUNCT B-O
it PRON B-O
is AUX B-O
critical ADJ B-O
that SCONJ B-O
they PRON B-O
remain VERB B-O
in ADP B-O
care NOUN B-O
throughout ADP B-O
their PRON B-O
pregnancy NOUN B-O
and CCONJ B-O
after ADP B-O
so SCONJ B-O
that SCONJ B-O
they PRON B-O
receive VERB B-O
the DET B-O
full ADJ B-O
package NOUN B-O
of ADP B-O
prevention NOUN B-O
of ADP B-O
mother NOUN B-O
- PUNCT B-O
to ADP B-O
- PUNCT B-O
child NOUN B-O
transmission NOUN B-O
of ADP B-O
HIV PROPN B-AC
( PUNCT B-O
PMTCT PROPN B-AC
) PUNCT B-O
services NOUN B-O
. PUNCT B-O

Primer NOUN B-O
pairs NOUN B-O
were AUX B-O
designed VERB B-O
for ADP B-O
three NUM B-O
different ADJ B-O
open ADJ B-LF
reading NOUN I-LF
frame NOUN I-LF
( PUNCT B-O
ORF PROPN B-AC
) PUNCT B-O
regions NOUN B-O
of ADP B-O
ASH1 PROPN B-O
, PUNCT B-O
a DET B-O
distinct ADJ B-O
region NOUN B-O
within ADP B-O
the DET B-O
ORF PROPN B-AC
regions NOUN B-O
of ADP B-O
PMA1 PROPN B-O
and CCONJ B-O
FBA1 NOUN B-O
, PUNCT B-O
the DET B-O
promoter NOUN B-O
, PUNCT B-O
coding VERB B-O
and CCONJ B-O
terminator NOUN B-O
regions NOUN B-O
of ADP B-O
ADH1 PROPN B-O
, PUNCT B-O
as ADP B-O
well ADV B-O
as ADP B-O
for ADP B-O
a DET B-O
heterochromatic ADJ B-O
control NOUN B-O
region NOUN B-O
of ADP B-O
chromosome NOUN B-O
V. NOUN B-O
Dahlbäck PROPN B-O
et PROPN B-O
al NOUN B-O
. PUNCT B-O

observed VERB B-O
that SCONJ B-O
addition NOUN B-O
of ADP B-O
APC PROPN B-AC
to ADP B-O
plasma NOUN B-O
of ADP B-O
patients NOUN B-O
with ADP B-O
multiple ADJ B-O
thrombotic ADJ B-O
events NOUN B-O
did AUX B-O
not PART B-O
result VERB B-O
in ADP B-O
the DET B-O
expected VERB B-O
prolongation NOUN B-O
of ADP B-O
the DET B-O
coagulation NOUN B-O
time NOUN B-O
in ADP B-O
an DET B-O
activated VERB B-LF
partial ADJ I-LF
thromboplastin NOUN I-LF
time NOUN I-LF
( PUNCT B-O
aPTT PROPN B-AC
) PUNCT B-O
assay NOUN B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
. PUNCT B-O

Graphs NOUN B-O
illustrate VERB B-O
performance NOUN B-O
for ADP B-O
these DET B-O
scenarios NOUN B-O
, PUNCT B-O
ranked VERB B-O
in ADP B-O
order NOUN B-O
of ADP B-O
relative ADJ B-O
performance NOUN B-O
for ADP B-O
four NUM B-O
metrics NOUN B-O
: PUNCT B-O
RMSE PROPN B-AC
( PUNCT B-O
Root NOUN B-O
Mean NOUN B-O
Square PROPN B-O
Error NOUN B-O
) PUNCT B-O
, PUNCT B-O
MAE PROPN B-AC
( PUNCT B-O
Mean NOUN B-LF
Absolute PROPN I-LF
Error NOUN I-LF
) PUNCT B-O
, PUNCT B-O
R NOUN B-O
- PUNCT B-O
squared NOUN B-O
and CCONJ B-O
Spearman PROPN B-O
correlation NOUN B-O
coefficient NOUN B-O
. PUNCT B-O

Risky ADJ B-O
sexual ADJ B-O
behavior NOUN B-O
may AUX B-O
result VERB B-O
in ADP B-O
serious ADJ B-O
health NOUN B-O
problems NOUN B-O
such ADJ B-O
as ADP B-O
unintended ADJ B-O
pregnancy NOUN B-O
, PUNCT B-O
abortion NOUN B-O
, PUNCT B-O
and CCONJ B-O
sexually ADV B-LF
transmitted VERB I-LF
infections NOUN I-LF
( PUNCT B-O
STIs PROPN B-AC
) PUNCT B-O
including VERB B-O
HIV PROPN B-AC
[ PUNCT B-O
19 NUM B-O
] PUNCT B-O
. PUNCT B-O

In ADP B-O
low ADJ B-LF
resource NOUN I-LF
settings NOUN I-LF
( PUNCT B-O
LRSs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
treatment NOUN B-O
of ADP B-O
neonatal ADJ B-O
jaundice NOUN B-O
is AUX B-O
often ADV B-O
sub ADJ B-O
- ADJ B-O
optimal ADJ B-O
[ PUNCT B-O
4 NUM B-O
, PUNCT B-O
5 NUM B-O
] PUNCT B-O
. PUNCT B-O

In ADP B-O
2015 NUM B-O
, NOUN B-O
the DET B-O
prevalence NOUN B-O
of ADP B-O
low ADJ B-O
birth NOUN B-O
weight NOUN B-O
per ADP B-O
100 NUM B-O
births NOUN B-O
was AUX B-O
greater ADJ B-O
in ADP B-O
southern ADJ B-O
Asia PROPN B-O
than ADP B-O
in ADP B-O
sub ADJ B-O
- ADJ B-O
Saharan ADJ B-O
Africa PROPN B-O
( PUNCT B-O
26.4 NUM B-O
% NOUN B-O
; NOUN B-O
uncertainty NOUN B-LF
range NOUN I-LF
[ PUNCT B-O
UR PROPN B-AC
] PUNCT B-O
: PUNCT B-O
18.6–35.2 NUM B-O
versus ADP B-O
14.0 NUM B-O
% NOUN B-O
, NOUN B-O
UR PROPN B-AC
: PUNCT B-O
12.2–17.2 NUM B-O
) PUNCT B-O
[ PUNCT B-O
28 NUM B-O
] PUNCT B-O
. PUNCT B-O

Three NUM B-O
retinoic ADJ B-LF
acid NOUN I-LF
receptors NOUN B-O
( PUNCT B-O
RARα PROPN B-O
, PUNCT B-O
RARβ PROPN B-O
and CCONJ B-O
RARγ NOUN B-O
) PUNCT B-O
have AUX B-O
been AUX B-O
identified VERB B-O
as ADP B-O
cognate NOUN B-O
receptors NOUN B-O
for ADP B-O
RA PROPN B-AC
. PUNCT B-O

These DET B-O
RARs NOUN B-O
are AUX B-O
structurally- ADV B-O
and CCONJ B-O
functionally ADV B-O
- PUNCT B-O
conserved VERB B-O
nuclear ADJ B-O
retinoid NOUN B-O
receptors NOUN B-O
[ PUNCT B-O
36–39 NUM B-O
] PUNCT B-O
. PUNCT B-O

CCHQ PROPN B-AC
= PUNCT B-O
Care PROPN B-LF
and CCONJ I-LF
Comfort PROPN I-LF
Hypertonicity PROPN I-LF
Questionnaire PROPN I-LF
; PUNCT B-O
GMFCS PROPN B-AC
= PUNCT B-O
Gross ADJ B-LF
motor NOUN I-LF
functional ADJ I-LF
classification NOUN I-LF
scale NOUN I-LF
; PUNCT B-O
GMFM PROPN B-AC
= PUNCT B-O
Gross ADJ B-LF
Motor PROPN I-LF
Function NOUN I-LF
Measure NOUN I-LF
; PUNCT B-O
MACS PROPN B-AC