Little Bear meets Osmosis Jones

***Little Bear meets Osmosis Jones*** is an upcoming Little Bear/Warner Bros. Pictures crossover to be made by Hiatt Grey.

## Plot

Frank DeTorre is an unhealthy and lazy zookeeper at the Sucat Memorial Zoo in Rhode Island. Miserable by the death of his wife Maggie, he copes by overeating and foregoing basic hygiene, much to his daughter Shane's embarrassment. Inside his body, which is called the "City of Frank" by its anthropomorphic inhabitants, white blood cell Osmosis "Ozzy" Jones is a maverick officer of the Frank Police Department, the city's center for responses against bodily threats. After Ozzy - against orders - induced Frank to vomit a contaminated oyster onto Shane's teacher Mrs. Boyd, Frank lost his previous job at a pea soup factory and was banned from visiting Shane's school, and Ozzy was demoted to patrol duty in the mouth.

Some time afterward, facing a serious challenge to his re-election prospects, Mayor Phlegmming doubles down on his junk food policies, ignoring their effect on Frank's health. This induces Frank to eat a boiled egg that fell into a chimpanzee's habitat, allowing Thrax, a virus known as La Muerte Roja, to enter his body; to alleviate the safety concerns of his secretary Leah Estrogen, Phlegmming then instructs Frank to take a cold pill through brain signals. The pill, Drixenol "Drix" Koldreliff, proceeds to disinfect the throat, covering up evidence of Thrax's arrival. Ozzy is told to assist Drix in his investigation, much to his chagrin. Thrax assumes leadership of a gang of sweat germs and launches an attack on the mucus dam in Frank's nose, nearly killing Drix before Ozzy rescues him.

The duo pay a visit to Chill, a cell from a flu vaccine and one of Ozzy's informants. Chill directs them to Thrax's hideout - a germ-ridden nightclub in a large zit on Frank's forehead. Ozzy goes undercover and infiltrates Thrax's gang, where he learns that Thrax, wanting to be known as the most dangerous virus in medical history, intends to masquerade as a common cold and use his knowledge of DNA to kill Frank within forty-eight hours. When Ozzy is discovered, Drix comes to his aid, causing a brawl which culminates in the zit being popped by a grenade. The pus lands on Mrs. Boyd's lip during a conversation between her and Frank, foiling Frank's one chance to apologize to her. In response, Phlegmming furiously closes the investigation, has Ozzy fired from the force and reminds Drix that pills are only to remain in the body temporarily before ordering him to leave.

Unbeknownst to the duo, Thrax has survived the zit's destruction. After killing his remaining henchmen, he proceeds to launch a lone assault on the hypothalamus, where he steals a crucial nucleotide. He then abducts Leah and flees to the mouth to escape. His actions disable the body's ability to regulate temperature, causing Frank to develop a severe fever. As Frank is taken to the hospital, Ozzy, having discovered Thrax's survival, reunites with Drix and convinces him not to leave. The two catch up to Thrax in the uvula and rescue Leah. Thrax uses pollen to induce Frank to sneeze, riding the 'wind' out of the mouth. Drix then shoots Ozzy out of the mouth after Thrax, and they land on Shane's cornea. As they fight, they fall onto one of Shane's false eyelashes, dislodging it. Ozzy tricks Thrax into getting his hand embedded in the lash, and escapes just as the lash falls into a beaker of rubbing alcohol, where Thrax dissolves.

As Frank's temperature surpasses 108 degrees, he goes into cardiac arrest. Riding on one of Shane's tears as she mourns her father, Ozzy returns to Frank's body with the stolen nucleotide, reviving him just in time. Ozzy is welcomed back into the police force and enters a relationship with Leah, while Drix is allowed to stay in the body as Ozzy's new partner. Having narrowly cheated death, Frank commits himself to living a healthier lifestyle, which results in Phlegmming losing the election to his opponent, Tom Colonic, in a landslide. Phlegmming is reduced to janitorial duty in the bowels, where he accidentally triggers Frank's flatulence, ejecting himself from the body.

## Trivia

* Belle, Gordon Quid, Waffle, Mr. Blik, One, Two, Three, Four, Five, Six, Seven, SpongeBob SquarePants, Patrick Star, Squidward Tentacles, Sandy Cheeks, Mr. Krabs, Jenny Wakeman, Dudley Puppy, Kitty Katswell, the Powerpuff Girls (Blossom, Bubbles, and Buttercup), Dexter, Lazlo, Raj, Clam, Queen Anna, Elsa, Kristoff, Sven, Princess Rapunzel, Flynn Rider, Maximus, Pascal, Wreck-It Ralph, Fix-It Felix Jr., Vanellope von Schweetz, Sergeant Calhoun, Judy Hopps, Nick Wilde, Flik, Francis, Slim, Heimlich, Dim, Rosie, Gypsy, Manny, Tuck, Roll, Lightning McQueen, Mater, Sally Carrera, Luigi, Guido, Ramone, Flo, Sheriff, Fillmore, Sarge, Lizzie, Red, Mack, Lady, Tramp, Scamp, Annette, Collette, Danielle, Angel, Duchess, Thomas O'Malley, Toulouse, Marie, Berlioz, Oliver, Dodger, Tito, Francis, Einstein, Rita, Georgette, Jenny Foxworth, James P. Sullivan, Mike Wazowski, Chicken Little, Abby Mallard, Fish Out of Water, Runt of the Litter, Alex, Marty, Melman, Gloria, the Penguins (Skipper, Kowalski, Private, and Rico), King Julien, Maurice, Mort, Gia, Stefano, Vitaly, Rodney Copperbottom, Fender Pinwheeler, Wonderbot, Piper Pinwheeler, Crank Casey, Lugnut, Diesel, Wilbur, Cardigan, Nellie, Aranea, Joy, Templeton, Ash Ketchum, Pikachu, Misty, Brock, May, Max, Dawn, Piplup, Molly Hale, Tory Lund, Plusle, Minun, Rafe, Audrey and Kathryn, Sid, Rebecca, Sailor Moon, Tuxedo Mask, Sailor Chibi Moon, the Sailor Guardians (Sailor Mercury, Sailor Mars, Sailor Jupiter, Sailor Venus, Sailor Pluto, Sailor Uranus, Sailor Neptune, and Sailor Saturn), Luna, Artemis, Diana, Max Taylor, Zoe Drake, and Rex Owen guest star in this film.
* Diesel 10 will work for Thrax in this film.
* *The Little Bear Movie*, *Lady and the Tramp II: Scamp's Adventure*, *Monsters, Inc.*, *Pokémon 3: The Movie*, and *Osmosis Jones* were both released in the year, 2001.
* *The Powerpuff Girls Movie*, the first three *Pokémon* films, *Pokémon: Mewtwo Returns*, *Pokémon: Detective Pikachu*, and *Osmosis Jones* were all released by Warner Bros. Pictures.
* Marty and Osmosis Jones are both voiced by Chris Rock.
* Slim and Drix were both voiced by David Hyde Pierce.