PH-responsive...

1: Wang J, Xu W, Guo H, Ding J, Chen J, Guan J, Wang C. Selective intracellular

drug delivery from pH-responsive polyion complex micelle for enhanced malignancy

suppression in vivo. Colloids Surf B Biointerfaces. 2015 Jul 26;135:283-290. doi:

10.1016/j.colsurfb.2015.07.065. [Epub ahead of print] PubMed PMID: 26277711.

2: Colombo S, Brisander M, Haglöf J, Sjövall P, Andersson P, Østergaard J,

Malmsten M. Matrix effects in nilotinib formulations with pH-responsive polymer

produced by carbon dioxide-mediated precipitation. Int J Pharm. 2015 Aug 11. pii:

S0378-5173(15)30129-0. doi: 10.1016/j.ijpharm.2015.08.031. [Epub ahead of print]

PubMed PMID: 26276256.

3: Hebeish A, Farag S, Sharaf S, Shaheen TI. Radically new cellulose

nanocomposite hydrogels: Temperature and pH responsive characters. Int J Biol

Macromol. 2015 Aug 11. pii: S0141-8130(15)00549-8. doi:

10.1016/j.ijbiomac.2015.08.014. [Epub ahead of print] PubMed PMID: 26275463.

4: Meng LB, Zhang W, Li D, Li Y, Hu XY, Wang L, Li G. pH-Responsive

supramolecular vesicles assembled by water-soluble pillar[5]arene and a BODIPY

photosensitizer for chemo-photodynamic dual therapy. Chem Commun (Camb). 2015 Aug

13. [Epub ahead of print] PubMed PMID: 26270623.

5: Shrestha N, Shahbazi MA, Araújo F, Mäkilä E, Raula J, Kauppinen EI, Salonen J,

Sarmento B, Hirvonen J, Santos HA. Multistage pH-responsive mucoadhesive

nanocarriers prepared by aerosol flow reactor technology: A controlled dual

protein-drug delivery system. Biomaterials. 2015 Jul 26;68:9-20. doi:

10.1016/j.biomaterials.2015.07.045. [Epub ahead of print] PubMed PMID: 26253804.

6: Zhao H, Li Z, Yang B, Wang J, Li Y. Synthesis of Dual-functional Targeting

Probes for Cancer Theranostics Based on Iron Oxide Nanoparticles Coated by

Centipede-like Polymer Connected with pH-Responsive Anticancer Drug. J Biomater

Sci Polym Ed. 2015 Aug 7:1-30. [Epub ahead of print] PubMed PMID: 26249213.

7: Qi C, Zhu YJ, Sun TW, Wu J, Chen F. Microwave-assisted hydrothermal rapid

synthesis of amorphous calcium phosphate mesoporous microspheres using adenosine

5'-diphosphate and application in pH-responsive drug delivery. Chem Asian J. 2015

Aug 7. doi: 10.1002/asia.201500667. [Epub ahead of print] PubMed PMID: 26248600.

8: Eyley S, Vandamme D, Lama S, Van den Mooter G, Muylaert K, Thielemans W. CO(2)

controlled flocculation of microalgae using pH responsive cellulose nanocrystals.

Nanoscale. 2015 Aug 7. [Epub ahead of print] PubMed PMID: 26248574.

9: Yu M, Guo F, Wang J, Tan F, Li N. Photosensitizer-Loaded pH-Responsive Hollow

Gold Nanospheres for Single Light-Induced Photothermal/Photodynamic Therapy. ACS

Appl Mater Interfaces. 2015 Aug 19;7(32):17592-7. doi: 10.1021/acsami.5b05763.

Epub 2015 Aug 10. PubMed PMID: 26248033.

10: Ding Z, Li S, Cao X. Microbial Transglutaminase Separation by pH-Responsive

Affinity Precipitation with Crocein Orange G as the Ligand. Appl Biochem

Biotechnol. 2015 Aug 6. [Epub ahead of print] PubMed PMID: 26245259.

11: Pramod PS, Deshpande NU, Jayakannan M. Real-Time Drug Release Analysis of

Enzyme and pH Responsive Polysaccharide Nanovesicles. J Phys Chem B. 2015 Aug 12.

[Epub ahead of print] PubMed PMID: 26237375.

12: Peng T, Lee H, Lim S. Design of a reversible inversed pH-responsive caged

protein. Biomater Sci. 2015 Apr 17;3(4):627-35. doi: 10.1039/c4bm00313f. Epub

2015 Feb 9. PubMed PMID: 26222423.

13: Narambuena CF, Longo GS, Szleifer I. Lysozyme adsorption in pH-responsive

hydrogel thin-films: the non-trivial role of acid-base equilibrium. Soft Matter.

2015 Aug 12;11(33):6669-79. doi: 10.1039/c5sm00980d. PubMed PMID: 26219383.

14: Shi Q, Zhang L, Liu M, Zhang X, Zhang X, Xu X, Chen S, Li X, Zhang J.

Reversion of multidrug resistance by a pH-responsive cyclodextrin-derived

nanomedicine in drug resistant cancer cells. Biomaterials. 2015 Jul

14;67:169-182. doi: 10.1016/j.biomaterials.2015.07.023. [Epub ahead of print]

PubMed PMID: 26218743.

15: Zhang S, Bellinger AM, Glettig DL, Barman R, Lee YL, Zhu J, Cleveland C,

Montgomery VA, Gu L, Nash LD, Maitland DJ, Langer R, Traverso G. A pH-responsive

supramolecular polymer gel as an enteric elastomer for use in gastric devices.

Nat Mater. 2015 Jul 27. doi: 10.1038/nmat4355. [Epub ahead of print] PubMed PMID:

16: Arnould A, Gaillard C, Fameau AL. pH-responsive fatty acid self-assembly

transition induced by UV light. J Colloid Interface Sci. 2015 Nov 15;458:147-54.

doi: 10.1016/j.jcis.2015.07.043. Epub 2015 Jul 21. PubMed PMID: 26210918.

17: Guha A, Biswas N, Bhattacharjee K, Das P, Kuotsu K. In vitro evaluation of pH

responsive doxazosin loaded mesoporous silica nanoparticles: A smart approach in

drug delivery. Curr Drug Deliv. 2015 Jul 22. [Epub ahead of print] PubMed PMID:

18: de León AS, Muñoz-Bonilla A, Gallardo A, Fernandez-Mayoralas A, Bernard J,

Rodríguez-Hernández J. Straightforward functionalization of breath figures:

Simultaneous orthogonal host-guest and pH-responsive interfaces. J Colloid

Interface Sci. 2015 Nov 1;457:272-80. doi: 10.1016/j.jcis.2015.06.039. Epub 2015

Jun 29. PubMed PMID: 26196710.

19: Hwang AA, Lee BY, Clemens DL, Dillon BJ, Zink JI, Horwitz MA. pH-Responsive

Isoniazid-Loaded Nanoparticles Markedly Improve Tuberculosis Treatment in Mice.

Small. 2015 Jul 20. doi: 10.1002/smll.201500937. [Epub ahead of print] PubMed

PMID: 26193431.

20: Yao X, Chen L, Chen X, Xie Z, Ding J, He C, Zhang J, Chen X. pH-responsive

metallo-supramolecular nanogel for synergistic chemo-photodynamic therapy. Acta

Biomater. 2015 Jul 16. pii: S1742-7061(15)30022-2. doi:

10.1016/j.actbio.2015.07.024. [Epub ahead of print] PubMed PMID: 26190797.

21: Monzel C, Veschgini M, Madsen J, Lewis AL, Armes SP, Tanaka M. Fine

Adjustment of Interfacial Potential between pH-Responsive Hydrogels and

Cell-Sized Particles. Langmuir. 2015 Aug 11;31(31):8689-96. doi:

10.1021/acs.langmuir.5b01896. Epub 2015 Jul 31. PubMed PMID: 26190346.

22: Davaran S, Lotfipour F, Sedghipour N, Sedghipour MR, Alimohammadi S, Salehi

R. Preparation and in vivo evaluation of in situ gel system as dual

thermo-/pH-responsive nanocarriers for sustained ocular drug delivery. J

Microencapsul. 2015;32(5):511-9. doi: 10.3109/02652048.2015.1065915. Epub 2015

Jul 20. PubMed PMID: 26190215.

23: Solanki A, Thakore S. Cellulose crosslinked pH-responsive polyurethanes for

drug delivery: α-hydroxy acids as drug release modifiers. Int J Biol Macromol.

2015 Jul 16;80:683-691. doi: 10.1016/j.ijbiomac.2015.07.003. [Epub ahead of

print] PubMed PMID: 26188306.

24: Li J, Jia Y, Dong W, Wang A, Li J. pH responsive ATP carriers to drive

kinesin movement. Chem Commun (Camb). 2015 Jul 30;51(65):13044-6. doi:

10.1039/c5cc05251c. PubMed PMID: 26186258.

25: Li Z, Li J, Huang J, Zhang J, Cheng D, Shuai X. Synthesis and

Characterization of pH-Responsive Copolypeptides Vesicles for siRNA and

Chemotherapeutic Drug Co-Delivery. Macromol Biosci. 2015 Jul 17. doi:

10.1002/mabi.201500161. [Epub ahead of print] PubMed PMID: 26184375.

26: Yan L, Crayton SH, Thawani JP, Amirshaghaghi A, Tsourkas A, Cheng Z. A

pH-Responsive Drug-Delivery Platform Based on Glycol Chitosan-Coated Liposomes.

Small. 2015 Jul 16. doi: 10.1002/smll.201501412. [Epub ahead of print] PubMed

PMID: 26183232.

27: Bhuiyan MP, Aryal MP, Janic B, Karki K, Varma NR, Ewing JR, Arbab AS, Ali MM.

Concentration-independent MRI of pH with a dendrimer-based pH-responsive

nanoprobe. Contrast Media Mol Imaging. 2015 Jul 14. doi: 10.1002/cmmi.1651. [Epub

ahead of print] PubMed PMID: 26173742.

28: Bhaskar U, Hickey AM, Li G, Mundra RV, Zhang F, Fu L, Cai C, Ou Z, Dordick

JS, Linhardt RJ. A purification process for heparin and precursor polysaccharides

using the pH responsive behavior of chitosan. Biotechnol Prog. 2015 Jul 3. doi:

10.1002/btpr.2144. [Epub ahead of print] PubMed PMID: 26147064.

29: Chung MF, Liu HY, Lin KJ, Chia WT, Sung HW. A pH-Responsive Carrier System

that Generates NO Bubbles to Trigger Drug Release and Reverse

P-Glycoprotein-Mediated Multidrug Resistance. Angew Chem Int Ed Engl. 2015 Aug

17;54(34):9890-3. doi: 10.1002/anie.201504444. Epub 2015 Jul 1. PubMed PMID:

30: Chen R, Jiang H, Gu H, Zhou Q, Wu J, Chen D, Zhang J. A pH-responsive

fluorescent [5]pseudorotaxane formed by self-assembly of cationic water-soluble

pillar[5]arenes and a tetraphenylethene derivative. Chem Commun (Camb). 2015 Jul

16;51(61):12220-3. doi: 10.1039/c5cc04720j. PubMed PMID: 26134923.

31: Wang C, Cheng H, Huang Y, Xu Z, Lin H, Zhang C. Facile sonochemical synthesis

of pH-responsive copper nanoclusters for selective and sensitive detection of

Pb(2+) in living cells. Analyst. 2015 Jul 27;140(16):5634-9. doi:

10.1039/c5an00741k. PubMed PMID: 26133700.

32: Qian J, Sullivan BP, Berkland C. pH-Responsive Micelle Sequestrant Polymers

Inhibit Fat Absorption. Biomacromolecules. 2015 Aug 10;16(8):2340-6. doi:

10.1021/acs.biomac.5b00560. Epub 2015 Jul 17. PubMed PMID: 26133544.

33: Kondo S, Asano Y, Koizumi N, Tatematsu K, Sawama Y, Sasai Y, Yamauchi Y,

Kuzuya M, Kurosawa S. Novel pH-Responsive Polymeric Micelles Prepared through

Self-assembly of Amphiphilic Block Copolymer with Poly-4-vinylpyridine Block

Synthesized by Mechanochemical Solid-State Polymerization. Chem Pharm Bull

(Tokyo). 2015;63(7):489-94. doi: 10.1248/cpb.c14-00869. PubMed PMID: 26133065.

34: Zhou Z, Gu F, Peng L, Hu Y, Wang Q. Spectroscopic analysis and in vitro

imaging applications of a pH responsive AIE sensor with a two-input inhibit

function. Chem Commun (Camb). 2015 Jul 14;51(60):12060-3. doi:

10.1039/c5cc03788c. PubMed PMID: 26121058.

35: Rossi B, Venuti V, D'Amico F, Gessini A, Mele A, Punta C, Melone L, Crupi V,

Majolino D, Trotta F, Masciovecchio C. Toward an understanding of the

thermosensitive behaviour of pH-responsive hydrogels based on cyclodextrins. Soft

Matter. 2015 Jul 15;11(29):5862-71. doi: 10.1039/c5sm01093d. PubMed PMID:

36: Heinzelman P, Krais J, Ruben E, Pantazes R. Engineering pH responsive

fibronectin domains for biomedical applications. J Biol Eng. 2015 May 15;9:6.

doi: 10.1186/s13036-015-0004-1. eCollection 2015. PubMed PMID: 26106447; PubMed

Central PMCID: PMC4477602.

37: Lane DD, Su FY, Chiu DY, Srinivasan S, Wilson JT, Ratner DM, Stayton PS,

Convertine AJ. Dynamic intracellular delivery of antibiotics via pH-responsive

polymersomes. Polym Chem. 2015 Feb 28;6(8):1255-1266. PubMed PMID: 26097513;

PubMed Central PMCID: PMC4470576.

38: Luo YL, Han M, Xu F, Chen YS, Zhang YQ. pH-Responsive H-Type PMAA(2)

-b-HTPBN-b-PMAA(2) Four-Arm Star Block Copolymer Micelles for PTX Drug Release.

Macromol Biosci. 2015 Jun 11. doi: 10.1002/mabi.201500103. [Epub ahead of print]

PubMed PMID: 26096959.

39: Li L, Knickelbein K, Zhang L, Wang J, Obrinske M, Ma GZ, Zhang LM, Bitterman

L, Du W. Amphiphilic sugar poly(orthoesters) as pH-responsive nanoscopic

assemblies for acidity-enhanced drug delivery and cell killing. Chem Commun

(Camb). 2015 Aug 4;51(66):13078-81. doi: 10.1039/c5cc04078g. PubMed PMID:

40: Wang X, Wu Y, Soesbe TC, Yu J, Zhao P, Kiefer GE, Sherry AD. A pH-Responsive

MRI Agent that Can Be Activated Beyond the Tissue Magnetization Transfer Window.

Angew Chem Int Ed Engl. 2015 Jul 20;54(30):8662-4. doi: 10.1002/anie.201502497.

Epub 2015 Jun 11. PubMed PMID: 26096197.

41: Hu J, Xie L, Zhao W, Sun M, Liu X, Gao W. Design of tumor-homing and

pH-responsive polypeptide-doxorubicin nanoparticles with enhanced anticancer

efficacy and reduced side effects. Chem Commun (Camb). 2015 Jul 2;51(57):11405-8.

doi: 10.1039/c5cc04035c. PubMed PMID: 26086450.

42: Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Muñoz A, Walker LA,

Herbst S, Safari M, Cheverton AM, Chen D, Liu H, Saijo S, Fedorova ND,

Armstrong-James D, Munro CA, Read ND, Filler SG, Espeso EA, Nierman WC, Haas H,

Bignell EM. Correction: The pH-Responsive PacC Transcription Factor of

Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during

Pulmonary Aspergillosis. PLoS Pathog. 2015 Jun 18;11(6):e1004943. doi:

10.1371/journal.ppat.1004943. eCollection 2015 Jun. PubMed PMID: 26086393; PubMed

Central PMCID: PMC4472839.

43: Tang X, Dai J, Xie J, Zhu Y, Zhu M, Wang Z, Xie C, Yao A, Liu T, Wang X, Chen

L, Jiang Q, Wang S, Liang Y, Xu C. Enhanced Antifungal Activity by Ab-Modified

Amphotericin B-Loaded Nanoparticles Using a pH-Responsive Block Copolymer.

Nanoscale Res Lett. 2015 Dec;10(1):969. doi: 10.1186/s11671-015-0969-1. Epub 2015

Jun 10. PubMed PMID: 26061446; PubMed Central PMCID: PMC4486495.

44: Das S, Subuddhi U. pH-Responsive guar gum hydrogels for controlled delivery

of dexamethasone to the intestine. Int J Biol Macromol. 2015 Aug;79:856-63. doi:

10.1016/j.ijbiomac.2015.06.008. Epub 2015 Jun 7. PubMed PMID: 26056988.

45: Yamamura M, Takizawa H, Nabeshima T. Zwitterionic N2O2-Type Protonated

Dipyrrin Bearing a Phosphate Anionic Moiety as a pH-Responsive Fluorescence

Indicator. Org Lett. 2015 Jun 19;17(12):3114-7. doi: 10.1021/acs.orglett.5b01414.

Epub 2015 Jun 4. PubMed PMID: 26042936.

46: Gao Y, Zhou Y, Zhao L, Zhang C, Li Y, Li J, Li X, Liu Y. Enhanced antitumor

efficacy by cyclic RGDyK-conjugated and paclitaxel-loaded pH-responsive polymeric

micelles. Acta Biomater. 2015 Sep 1;23:127-35. doi: 10.1016/j.actbio.2015.05.021.

Epub 2015 May 23. PubMed PMID: 26013038.

47: Li Y, Chen H, Liu D, Wang W, Liu Y, Zhou S. pH-Responsive Shape Memory

Poly(ethylene glycol)-Poly(ε-caprolactone)-based Polyurethane/Cellulose

Nanocrystals Nanocomposite. ACS Appl Mater Interfaces. 2015 Jun

17;7(23):12988-99. doi: 10.1021/acsami.5b02940. Epub 2015 Jun 2. PubMed PMID:

48: Mahdavinia GR, Etemadi H, Soleymani F. Magnetic/pH-responsive beads based on

caboxymethyl chitosan and κ-carrageenan and controlled drug release. Carbohydr

Polym. 2015 Sep 5;128:112-21. doi: 10.1016/j.carbpol.2015.04.022. Epub 2015 Apr

21. PubMed PMID: 26005146.

49: Gallon E, Matini T, Sasso L, Mantovani G, Armiñan de Benito A, Sanchis J,

Caliceti P, Alexander C, Vicent MJ, Salmaso S. Triblock Copolymer Nanovesicles

for pH-Responsive Targeted Delivery and Controlled Release of siRNA to Cancer

Cells. Biomacromolecules. 2015 Jul 13;16(7):1924-37. doi:

10.1021/acs.biomac.5b00286. Epub 2015 Jun 2. PubMed PMID: 25988940.

50: Chen Y, Ai K, Liu J, Sun G, Yin Q, Lu L. Multifunctional envelope-type

mesoporous silica nanoparticles for pH-responsive drug delivery and magnetic

resonance imaging. Biomaterials. 2015 Aug;60:111-20. doi:

10.1016/j.biomaterials.2015.05.003. Epub 2015 May 15. PubMed PMID: 25988726.

51: Zhang QM, Berg D, Mugo SM, Serpe MJ. Lipase-modified pH-responsive

microgel-based optical device for triglyceride sensing. Chem Commun (Camb). 2015

Jun 14;51(47):9726-8. doi: 10.1039/c5cc02853a. PubMed PMID: 25983030.

52: Buchner S, Schlundt A, Lassak J, Sattler M, Jung K. Structural and Functional

Analysis of the Signal-Transducing Linker in the pH-Responsive One-Component

System CadC of Escherichia coli. J Mol Biol. 2015 Jul 31;427(15):2548-61. doi:

10.1016/j.jmb.2015.05.001. Epub 2015 May 12. PubMed PMID: 25979249.

53: Kim BJ, Cheong H, Hwang BH, Cha HJ. Mussel-Inspired Protein Nanoparticles

Containing Iron(III)-DOPA Complexes for pH-Responsive Drug Delivery. Angew Chem

Int Ed Engl. 2015 Jun 15;54(25):7318-22. doi: 10.1002/anie.201501748. Epub 2015

May 12. PubMed PMID: 25968933.

54: Kim JY, Yang JH, Lee JH, Choi G, Park DH, Jo MR, Choi SJ, Choy JH. 2D

Inorganic-Antimalarial Drug-Polymer Hybrid with pH-Responsive Solubility. Chem

Asian J. 2015 May 12. doi: 10.1002/asia.201500347. [Epub ahead of print] PubMed

PMID: 25965188.

55: Ujjwal RR, Purohit MP, Patnaik S, Ojha U. General Reagent Free Route to pH

Responsive Polyacryloyl Hydrazide Capped Metal Nanogels for Synergistic

Anticancer Therapeutics. ACS Appl Mater Interfaces. 2015 Jun 3;7(21):11497-507.

doi: 10.1021/acsami.5b02452. Epub 2015 May 20. PubMed PMID: 25961335.

56: Kim HW, Kim JW, Jo SH, Lee CL, Lee WK, Park SS, Chung B, Yoo SI.

pH-Responsive assembly of metal nanoparticles and fluorescent dyes by diblock

copolymer micelles. Soft Matter. 2015 Jun 14;11(22):4402-7. doi:

10.1039/c5sm00824g. PubMed PMID: 25959746.

57: You JO, Rafat M, Almeda D, Maldonado N, Guo P, Nabzdyk CS, Chun M, LoGerfo

FW, Hutchinson JW, Pradhan-Nabzdyk LK, Auguste DT. pH-responsive scaffolds

generate a pro-healing response. Biomaterials. 2015 Jul;57:22-32. doi:

10.1016/j.biomaterials.2015.04.011. Epub 2015 Apr 21. PubMed PMID: 25956194.

58: Hsieh CJ, Chen YC, Hsieh PY, Liu SR, Wu SP, Hsieh YZ, Hsu HY. Graphene Oxide

Based Nanocarrier Combined with a pH-Sensitive Tracer: A Vehicle for Concurrent

pH Sensing and pH-Responsive Oligonucleotide Delivery. ACS Appl Mater Interfaces.

2015 Jun 3;7(21):11467-75. doi: 10.1021/acsami.5b02397. Epub 2015 May 18. PubMed

PMID: 25945595.

59: Manchun S, Dass CR, Cheewatanakornkool K, Sriamornsak P. Enhanced anti-tumor

effect of pH-responsive dextrin nanogels delivering doxorubicin on colorectal

cancer. Carbohydr Polym. 2015 Aug 1;126:222-30. doi:

10.1016/j.carbpol.2015.03.018. Epub 2015 Mar 18. PubMed PMID: 25933543.

60: Wang X, Li Z, Yang Y, Gong X, Liao Y, Xie X. Photomechanically Controlled

Encapsulation and Release from pH-Responsive and Photoresponsive Microcapsules.

Langmuir. 2015 May 19;31(19):5456-63. doi: 10.1021/acs.langmuir.5b01180. Epub

2015 May 7. PubMed PMID: 25924083.

61: Liu Q, Chen X, Jia J, Zhang W, Yang T, Wang L, Ma G. pH-Responsive

Poly(D,L-lactic-co-glycolic acid) Nanoparticles with Rapid Antigen Release

Behavior Promote Immune Response. ACS Nano. 2015 May 26;9(5):4925-38. doi:

10.1021/nn5066793. Epub 2015 Apr 24. PubMed PMID: 25898266.

62: Salehi R, Rasouli S, Hamishehkar H. Smart thermo/pH responsive magnetic

nanogels for the simultaneous delivery of doxorubicin and methotrexate. Int J

Pharm. 2015 Jun 20;487(1-2):274-84. doi: 10.1016/j.ijpharm.2015.04.051. Epub 2015

Apr 17. PubMed PMID: 25895723.

63: Bellingeri RV, Picco NY, Alustiza FE, Canova JV, Molina MA, Acevedo DF,

Barbero C, Vivas AB. pH-responsive hydrogels to protect IgY from gastric

conditions: in vitro evaluation. J Food Sci Technol. 2015 May;52(5):3117-22. doi:

10.1007/s13197-014-1337-3. Epub 2014 Apr 10. PubMed PMID: 25892818; PubMed

Central PMCID: PMC4397343.

64: Wang X, Niu D, Wu Q, Bao S, Su T, Liu X, Zhang S, Wang Q. Iron

oxide/manganese oxide co-loaded hybrid nanogels as pH-responsive magnetic

resonance contrast agents. Biomaterials. 2015 Jun;53:349-57. doi:

10.1016/j.biomaterials.2015.02.101. Epub 2015 Mar 17. PubMed PMID: 25890733.

65: Xu H, Zhang H, Wang D, Wu L, Liu X, Jiao Z. A facile route for rapid

synthesis of hollow mesoporous silica nanoparticles as pH-responsive delivery

carrier. J Colloid Interface Sci. 2015 Aug 1;451:101-7. doi:

10.1016/j.jcis.2015.03.057. Epub 2015 Apr 11. PubMed PMID: 25890118.

66: Heinzelman P, Schoborg JA, Jewett MC. pH responsive granulocyte

colony-stimulating factor variants with implications for treating Alzheimer's

disease and other central nervous system disorders. Protein Eng Des Sel. 2015 Apr

15. pii: gzv022. [Epub ahead of print] PubMed PMID: 25877663.

67: Niedermayer S, Weiss V, Herrmann A, Schmidt A, Datz S, Müller K, Wagner E,

Bein T, Bräuchle C. Multifunctional polymer-capped mesoporous silica

nanoparticles for pH-responsive targeted drug delivery. Nanoscale. 2015 May

7;7(17):7953-64. doi: 10.1039/c4nr07245f. PubMed PMID: 25865957.

68: Zhang Z, Lv Q, Gao X, Chen L, Cao Y, Yu S, He C, Chen X. pH-Responsive

Poly(ethylene glycol)/Poly(L-lactide) Supramolecular Micelles Based on Host-Guest

Interaction. ACS Appl Mater Interfaces. 2015 Apr 29;7(16):8404-11. doi:

10.1021/acsami.5b01213. Epub 2015 Apr 17. PubMed PMID: 25856564.

69: PLOS Pathogens Staff. Correction: The pH-responsive PacC transcription factor

of Aspergillus fumigatus governs epithelial entry and tissue invasion during

pulmonary aspergillosis. PLoS Pathog. 2015 Apr 8;11(4):e1004802. doi:

10.1371/journal.ppat.1004802. eCollection 2015 Apr. PubMed PMID: 25853727; PubMed

Central PMCID: PMC4390368.

70: Wang H, Zhao S, Agarwal P, Dumbleton J, Yu J, Lu X, He X. Multi-layered

polymeric nanoparticles for pH-responsive and sequenced release of theranostic

agents. Chem Commun (Camb). 2015 May 4;51(36):7733-6. doi: 10.1039/c5cc01833a.

PubMed PMID: 25850616.

71: Haldar U, Bauri K, Li R, Faust R, De P. Polyisobutylene-Based pH-Responsive

Self-Healing Polymeric Gels. ACS Appl Mater Interfaces. 2015 Apr

29;7(16):8779-88. doi: 10.1021/acsami.5b01272. Epub 2015 Apr 14. PubMed PMID:

72: Li L, Gu J, Zhang J, Xie Z, Lu Y, Shen L, Dong Q, Wang Y. Injectable and

Biodegradable pH-Responsive Hydrogels for Localized and Sustained Treatment of

Human Fibrosarcoma. ACS Appl Mater Interfaces. 2015 Apr 22;7(15):8033-40. doi:

10.1021/acsami.5b00389. Epub 2015 Apr 10. PubMed PMID: 25838258.

73: Adachi N, Kaneko Y, Sekiguchi K, Sugiyama H, Sugeno M. pH-responsive

fluorescence chemical sensor constituted by conjugated polymers containing

pyridine rings. Luminescence. 2015 Mar 31. doi: 10.1002/bio.2898. [Epub ahead of

print] PubMed PMID: 25828634.

74: Bai L, Zhao Q, Wang J, Gao Y, Sha Z, Di D, Han N, Wang Y, Zhang J, Wang S.

Mechanism study on pH-responsive cyclodextrin capped mesoporous silica: effect of

different stalk densities and the type of cyclodextrin. Nanotechnology. 2015 Apr

24;26(16):165704. doi: 10.1088/0957-4484/26/16/165704. Epub 2015 Apr 1. PubMed

PMID: 25827241.

75: Fernando IR, Ferris DP, Frasconi M, Malin D, Strekalova E, Yilmaz MD,

Ambrogio MW, Algaradah MM, Hong MP, Chen X, Nassar MS, Botros YY, Cryns VL,

Stoddart JF. Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous

silica nanoparticles for drug delivery. Nanoscale. 2015 Apr 28;7(16):7178-83.

doi: 10.1039/c4nr07443b. PubMed PMID: 25820516.

76: Fu J, Shao Y, Wang L, Zhu Y. Lysosome-controlled efficient ROS overproduction

against cancer cells with a high pH-responsive catalytic nanosystem. Nanoscale.

2015 Apr 28;7(16):7275-83. doi: 10.1039/c5nr00706b. PubMed PMID: 25813671.

77: Chen L, Cao W, Grishkewich N, Berry RM, Tam KC. Synthesis and

characterization of pH-responsive and fluorescent poly (amidoamine)

dendrimer-grafted cellulose nanocrystals. J Colloid Interface Sci. 2015 Jul

15;450:101-8. doi: 10.1016/j.jcis.2015.03.002. Epub 2015 Mar 10. PubMed PMID:

78: Zhang W, Xing L, Wang H, Liu X, Feng Y, Gao C. Preparation of novel porphyrin

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Release of Encapsulated Material within the Range of Intracellular pH Financial

support was provided by the NSF (Cooperative Agreement No. ECC9843342 to the MIT

Biotechnology Process Engineering Center), the NIH (GM26698), and the Department

of the Army (Cooperative Agreement DAMD 17-99-2-9-001 to the Center for

Innovative Minimally Invasive Therapy). D.M.L. wishes to thank the NIH for a

Postdoctoral Fellowship (NRSA Fellowship No. 1 F32 GM20227-01). Scanning electron

microscopy and confocal microscopy images were acquired by William Fowle at the

Northeastern University Center for Electron Microscopy. Dr. David Putnam, David

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