recursal/Fanatic-Fandom huggingface dataset:
Pyro Flarezon

## Pyro has exceptions to be non-realistic as he's a main editor of the page and a friend of Uarikao/Uikai.

Pyro

Words in Place of Pyro’s Picture..

> " *Well, When Your Enemies Don’t Die, You Just Bite them....*"
>
>
>

Information

Description

He is an Orange wolf that has flame patterns across his Pelt.

His underbelly is mostly black and most of his back, legs and tail have black stripes.

On his Muzzle he has a series of red, orange and yellow flames going up and then all the way down to his back.

His eyes are blood red in colour and have a single large scar going through his right eye.

**Likes**

The Colour Orange

Loyalty

The Night

(Memes)

Friends

Kindness to Others

Odd People

Lots of Food

Other Wolves

Open Flames

Uikai (Though She Doesn’t Like Him The Same Way Back R.I.P.)

Drawing

Getting Help From People Who Can Do Stuff Better

Chicken

**Dislikes**

The Colour Yellow

Discouragement

People Telling Him What He Can or Can’t Do

Torture

People Shipping Him With Water Wolves

People Telling Him to Stop Doing Something

School

Hard Work

Annoying People

Splash (A Water Wolf)

Itches

Stubbing His Paws

Illness

Reading

History

Pyro Flarezon a Young weak wolf was born on The Fifth Of May, in the galaxy Flara.
He specializes in fire and dark powers and abilities.
His parents died in war at a young age leaving him with his grandfather and older brother.
His grandfather was the strongest wolf in all of Flara.
But his older brother was not far behind grandfathers strength.
So he trained with them over many years.
So this is where the story stops because we are at present time.
Phagocytosis

Engulfment and destruction of pathogen.

## Phagosome maturation

The phagosome fuses with early endosomes, late endosomes then the lysosome.

The phagolysosome is a degradative compartment containing potent antimicrobial factors in an acidic environment.

## NADPH oxidase

This powerful complex is required to generate **reactive oxygen and nitrogen species**.

A **respiratory burst** is the rapid release of reactive oxygen species.
Immunoglobulin isotypes

Tfh cytokines influence which Ab isotype made by selected B cell.

## IgM

* Primary isotype during primary infections
* Blood
* Pentameric; large is size - not efficient at entering tissues
* Can be transported by poly Ig receptor

Functions

* C' activation
* Opsonization

## IgG

* Main Ab in blood
* Smaller than IgM → can enter tissue

* Taken up by pinocytosis from blood
	+ In endosome (acidic conditions), binds FcRn
	+ Vesicles fuses with basolateral membrane
	+ Neutral pH of extracellular environment → release of IgG from FcRn

Functions

* C' activation
* Opsonization
* Neutralization
	+ Toxins
* Transplacental transfer

## IgA

* Dimeric
* Blood and body secretions
	+ Maternal milk
* Transport to tissues via poly Ig receptor

Functions

* Neutralization
	+ Toxins
* Mucosal infections
Antiviral state

The antiviral state limits the host cell's ability to support viral replication by reducing the cell's ability to make protein. It requires dsRNA as the viral genome or replication intermediate.

IFN-α/-β released by viral-infected cells bind to nearby cells expressing a common IFN-α/-β receptor. Receptor engagement triggers a signalling cascade, inducing the transcription of IFN-stimulated genes.

Two important antiviral proteins are produced: **2',5'-oligoA synthetase (2',5'-OAS)** and **dsRNA dependent protein kinase (PKR).** The activities of these molecules inhibit the synthesis of both host and viral proteins.

## 2', 5'-OAS

2',5'-OAS enzyme activates RNase-L, which degrades mRNAs, both cellular and viral.

## PKR

Activated PKR inactivates eIF-2, an essential factor in translation.

###
Gut associated lymphoid tissue

The gut is heavily invested with immune cells in organized regions, including gut associated lymphoid tissue (GALT).

The GALT is populated with the same cell types in systemic immunity (lymphocytes, DCs and macrophages).

The environment of the GALT influences the behaviour and differentiation of immune cells in response to Ag.

The GALT is primarily proactive and avoids inflammation.

## Organization

In the small intestine, the surface is folded into finger-like projections called **villi.**

**Goblet cells** interspersed between enterocytes (epithelial cells) secrete mucus.

**Paneth cells** in **crypts** secrete anti-microbial factors, e.g. defensins, lysozyme.

**M cells,** "microfold" cells, are specialized to transport micro-organisms and Ags to the GALT.

## Peyer's patch

Peyer's patches (PPs) are found throughout the small intestine.

### Similarities and differences with lymph nodes

#### Similar

* Organization of T cell and B cell zones
* Cell types found (Ts, Bs, DCs)
* Lymphocytes can leave via efferent lymphatic
* Germinal centres can form for B cell class switching and somatic hypermutation

#### Different

* Cell entry
	+ LN = via blood (HEV) or afferent lymphatic
	+ PP = via blood (HEV)
* Ag entry
	+ LN = via afferent lymphatic, sometimes carried by DC
	+ PP = via M cell to be delivered to waiting DC
* Cell adhesion molecules
	+ To restrict entry to cells previously activated in the structure

## Isolated lymphoid follicle

Isolated lymphoid follicles (ILFs) are frequently found in the large intestine and, to a lesser extent, in the small intestine.

## Intestinal macrophages

In the LP, intestinal Mφs phagocytose bacteria and apoptotic cells. They constitutively secrete IL-10 to limit inflammation.

Unlike non-mucosal tissue Mφs, they are not instigators of inflammation. Intestinal macrophages do not...

* Produce pro-inflammatory cytokines
* Produce reactive oxygen or nitrogen species
* Express B7 co-stimulatory molecules
* Make cytokines needed for T cell activation and proliferation (not APCs)

## Intestinal DCs

Under resting conditions, DCs in the PP produce IL-10 in response to Ag uptake.

Everyday some mucosal DCs migrate to mLNs to present Ags to T cells. In the absence of infection/inflammation, naive CD4 T cells are activated to become FoxP3+ T regulatory cells. These T regs go to the wall of the small intestine to suppress inflammatory responses. This is important in the maintenance of tolerance to food Ags.
T cell activation

T cell activation involves 3 signals:

* Phosphorylated ITAM recruits **ZAP-70**, a cytoplasmic tyrosine kinase with SH2 domains that bind ITAMs
	+ ZAP-70 signals TCR engagement

### Signal 3 = Cytokines secreted by DC

* Polarize to specific effector type

* Note: effector T cells do not require co-stimulatory signals

**Summary**

 (TCR : MHC-peptide → ZAP-70) + (CD28 : B7 → JNK )

→ NFκB, AP-1, NFAT → IL-2 → proliferation
Medicine

*Never* use these yourself. The medicinal properties are unconfirmed, and many plants look alike and can be easily confused with one another.

## Medicines and Herbs

### Herbs

#### Valerian

Description: Talk stalks with many small, pinkish flowers, not to be confused with milkweed

Location: Grows in damp grassland

Usage: Stem is chewed into a pulp and ingested

Effect: Eases headaches, fever, and cramps

#### Blueberry

Description: Bush low to ground with bright blue berries and oval leaves

Location: Marshy areas

Usage: Berries are eaten

Effect: Fights infections

#### Wild Rose

Description: Large bush with bright pink flowers

Location: Grows in marshes and swamps

Usage: Hip of rose is harvested, washed, and ingested or applied to wound

Effect: Treats stress and infection

#### Buttercup

Description: Small yellow flowers

Location: Grows in fields

Usage: Leaves are chewed into a pulp

Effect: Eases joint pain

#### Milkweed

Description: Tall stalk with pale pink flowers, not to be confused with valerian

Location: Fields

Usage: Leaves are harvested and applied to wounds

Effect: Treats sores and burning

#### Everlasting

Description: Short plants with small, yellow buds

Location: Damp grasslands

Usage: Stalks ingested

Effects: Treats lung problems and mouth sores

#### Lupine

Description: Tall, bright purple or pink flowers

Location: Wetlands

Usage: Flowers chewed

Effect: Treats nausea

#### Trillium

Description: Large three-petaled flower growing close to ground facing sky

Location: Deep woods

Usage: Leaves ingested

Effect: Treats breathing problems

#### Lobelia

Description: Bright purple flowers growing out of tall stalk

Location: Damp grasslands

Usage: Whole plant ingested

Effect: Induces vomiting; flush out poison

#### Sweet Cicely

Description: Tall stalks with delicate white flowers

Location: Forest

Usage: Leaves ingested

Effect: Helps with production of milk and sleep problems

### Seaweeds

#### Dulse

Description: Dark reddish-brown or black when dried, red when wet

Location: Beaches after high tide, attached to rocks

Usage: Dried in sun then ingested

Effect: Strengthening effect, helps with digestion

#### Sea Lettuce

Description: Sticky bright green seaweed

Location: Washed up on beach, attached to rocks

Usage: Stretched over wounds

Effect: Stops bleeding, binds herbs in place, helps when making splints

#### Rockweed/Bladderwrack

Description: Dark brown seaweed with yellow bladders

Location: Often found attached to sides of rocks at high tide level

Usage: Bladders burst and juice is spread on body

Effect: Heals burns and fights infection

## Trivia

* This website was used to come up with most medicinal properties: https://botanical.com/botanical/mgmh/comindx.html. It is unknown how factual it is
* However, the properties of dulse are *somewhat* confirmed. Dulce is commonly eaten on the island where Bayclan is based off of (I have tried it, can't say I'd recommend it)
* The information for the seaweeds was found here: https://harmonicarts.ca/2014/02/glimpse-therapeutic-benefits-seaweeds/
* All of these plants are naturally found in the area where Bayclan is based off of
Eu Nao Ganhei

**Eu Nao Ganhei**is a Brazilian rock song recorded in 1989.

## Lyrics (Portuguese)

(27-second music prelude)

Agora eu vo a me mandar

Vo apertar na velocidade

E eu vo me movomentar

No valoca da cidade

Valeu, whoo hoo hoo hoo hoo

E bossa, que o bossa e nossa

Whoo hoo hoo hoo hoo

E verdade, essa bossa da cidade

Se alguma grana eu nao ganhei

Eu nao vo esquentar, nessas ruas eu so rei

Se algume grana eu nao ganhei

Eu nao vo chegar na tristeza, nessas ruas eu so rei

Espera o quem decide, o que bom e o que legau

Se voce nao prender comigo, voce vai sigar mau!

Se alguma grana (valeu) eu nao ganhei

Eu nao vo esquentar, nessas ruas eu so rei

Se alguma grana eu nao ganhei

Eu nao vo chegar na tristeza, nesses ruas eu so rei

"Voce e bom, agente vai dessiz"

No meio das garotas/garotos que eu fico mais feliz!

Eu so um boa, sei me cansar

Depoiz diga eu quero, sica vida vai mudar
Dendritic cell

DCs link innate and adaptive immunity.

## Types

### Plasmacytoid DCs

Type of DC that produces copious amounts of IFN in response to the detection of viral infection through its TLRs.

### Myeloid DCs

Conventional DCs (professional APCs) process ingested pathogens and activate naive T cells.

### Follicular DCs

Non-lymphoid cell in follicles of secondary lymphoid tissues.

Crucial in

* Ag capture and presentation to B cells
* B cell maturation
* Formation of germinal centres
* Selecting Ag-binding B cells during Ab responses

## Maturation

### Immature DCs

* highly phagocytic
* poorly equipped as APCs; low expression of...
	+ MHC class I and II
	+ co-stimulatory molecules
	+ chemokine receptors for migration and homing to lymphoid organs
	+ cytokine production

### Maturation process

After ingestion of Ag, maturation begins as DC leaves infection site and migrates to LN.

Express chemokine receptors (CCR7) for migration and entry to lymphoid tissues.

Upregulate expression of MHC I and II, co-stimulatory molecules and cell adhesion molecules.

Mature DCs are non-phagocytic and express the co-stimulatory molecule B7.
HCV hijacking of host lipid metabolism pathway

HCV hijacks critical molecules of host lipid metabolism pathways to support its **life cycle.**

## Liver is the main target organ

HCV exhibits **hepatotropism.**

HCV circulates as lipo-viro-particles (**LVPs).** LVPs have liver-specific receptors that mediate binding and uptake in hepatocytes (attachment and entry).

## HCV infection of hepatocytes result in LVPs

HCV hijacks the **VLDL-secretory pathway** and associated apolipoproteins for its assembly and maturation.

## Liver cells can support translation

Liver-specific host factors include **miR-122**. HCV hijacks miR-122 to stabilize its genome and stimulate translation.

## Liver cells can support replication

HCV proteins induce the rearrangement of ER-derived membranes. Leads to the formation of replicase complexes (**RCs)** in modified **membranous webs** associated with LD.

## Liver cells can support assembly

HCV hijacks host lipoprotein synthesis pathways (**lipid droplet** formation) required for the formation of assembly platforms.
Case study: Hemolytic disease of the newborn

Transplacental transfer of IgG via FcRn can transport Abs from mother to fetus.

If a mother is Rh- and a baby is Rh+, the mother may become sensitized to the Rh factor present in the fetus and produce alloantibodies directed against the Rh factor.

Anti-Rh Abs cross the placenta and enter fetal circulation. These Abs bind to fetal RBCs, marking them for destruction.

Risk of sensitization is increased with subsequent pregnancies.

### ABO incompatibility

Risk of sensitization is decreased if fetus is incompatible with mother.

## Coombs test

Direct test = sample of fetus RBCs

Indirect test = sample of woman's serum incubated with Rh+ RBCs

## Prevention

Passive immunization with low concentration of anti-Rh antibodies. The antibodies bind Rh+ fetal RBCs and FcγRIIBI, inducing apoptosis in the naive anti-Rh B cell.
Primary immune deficiencies

Defects in B cells and T cells

## B cell immune deficiencies

Agammaglobulinemia

**Hyper IgM (HIGM)** = B cells cannot class-switch because

* Deficiency in AID enzyme
* Deficiency in CD40 or CD40L

**Common variable immune deficiency (CVID)** = B cells cannot differentiate into plasma cells

Most patients are diagnosed in their 30s or 40s.
Recognition molecules of innate immunity

Pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs), common structures found on broad classes of pathogens that are not on host cells. These host sensors are germ-line encoded and do not undergo somatic recombination.

There are 4 main groups of PRRs:

* Membrane-bound phagocytic receptors (e.g. mannose receptor)
* Membrane-bound signalling receptors (e.g. TLRs)
* Cytoplasmic signalling receptors (e.g. NLRs)
* Soluble proteins in serum (e.g. MBL)

## Membrane-bound signalling receptors

### Toll-like receptors (TLRs)

#### Plasma membrane-bound

**TLR-2/6**

**TLR-1/2**

**TLR-4 :** LPS

**TLR-5**

#### Endosomal membrane-bound

In general, TLRs localized on endosomes recognize foreign nucleic acids. TLRs 3, 7 and 8 recognize viral nucleic acids.

**TLR-3 :** dsRNA

**TLR-7 :** ssRNA

**TLR-8 :** ssRNA

**TLR-9 :** DNA

## Cytoplasmic signalling receptors

### RIG-1-like receptors (RLRs)

RLRs recognize viral RNA. Signalling pathways lead to the expression of type 1 IFNs.

## Soluble proteins in serum

### Inflammatory cytokines

*See inflammation*

Upon pathogen recognition, resident macrophages release inflammatory cytokines (**IL-1**, **IL-6** and **TNF-α**).

Specifically, IL-6 induces the acute-phase response, trigger changes in blood plasma protein concentrations.

### C-reactive protein (CRP) and mannose-binding lectin (MBL)

*See Complement activation*

These proteins function like early-evolutionary antibodies. They can activate complement and function as opsonins.
Acute phase response

IL-6 induces the production of C-reactive protein (CRP) and mannose-binding lectin (MBL) in the liver.

CRP and MBL function like early-evolutionary Abs. Both can activate complement and function as opsonins.

## CRP pathway

CRP recognizes phosphocholine on bacterial surfaces.

Similar to the classical pathway, including use of C1q.

## MBL pathway

MBL recognizes carbohydrates (mannose sugars) on bacterial surfaces.

Requires MASP-1 and MASP2 to activate complement. MASP (MBL-serine protease) functions like C1q - acts like a protease to activate other C' components.

## Other proteins

LPS-binding protein (LBP) for recognition of LPS by TLR-4.

Complement components.
Adaptive response to intracellular bacteria

To generate a **cell-mediated response** to intracellular bacteria, cytokines produced by DC (signal 3) polarize naive CD4s to the Th1 phenotype (IL-12 and IFN-γ).

Th1s can super-activate macrophages to promote killing of phagocytosed bacteria. NKs are also important in providing IFN-γ to activate naive CD4s and macrophages.

## "Super-activating" macrophages

2 signals for activation:

1. TCR : MHC II-peptide
2. CD40L : CD40

This combination of signals induce changes in gene expression to allow...

* Better fusion of phagosomes with lysosomes
* Increased production of toxic oxygen radicals (also damaging to healthy tissues)

## Granuloma formation

Some intracellular bacteria persist inside macrophages, leading to chronic, low-level infection. An ongoing Th1 response is required to limit proliferation and spread of bacteria, leading to the formation of a granuloma.

In the case of tuberculosis, the centres of granulomas can become **necrotic**. Cells in the centre begin to die due to noxious stimuli, including toxic products of activated macrophages.

Macrophages attempt to wall off substances that they are not able to eliminate. These macrophages may be surrounded by Th cells.
Marshclan

Mistralclan: Ambivalent

Marshclan is one of the four clans featured in the Adventures in Bayclan series. They are a group of cats living in a salt marsh and the beach that borders it.

## Description

Marshclan is an extremely friendly clan. They are overly-trusting and often share their abundance of prey with other cats. They can swim to an extent, but are not as skilled as Bayclan cats. They are renowned for their stealth in the marsh, and can sneak up on nearly anything, though they lose their touch once they leave their home territory. They are fiercely loyal to their allies. They often get caught in between Highclan and Bayclan's skirmishes, being friendly towards both of them. They run on a monarchy, instead of the clan's current leader choosing the next. The firstborn kit of the leader will become the next leader after they die. The clan still has deputies, who will take over as leader if the leader and their family dies. This system is kept a secret, as the other clans look down upon it.

## Appearance

Marshclan cats are usually really small. They're beautiful shades of gold, brown, and cream, and their fur is usually complemented by highlights and complex patterns. Classic tabby, spotted tabby, ticked tabby, and colourpoint are extremely common patterns. Other pelts are rare in Marshclan. They're considered the most beautiful clan of cats. They're extremely fast.

## Territory

### Adventures in Bayclan

In Adventures in Bayclan, Marshclan's territory was very small. It was located on a flat salt marsh with the occasional stream.Their camp was in a depression in the ground, with dens lining the hole. It became extremely muddy when wet. Prey was abundant.

### The Coming Storm

Marshclan's territory is much bigger in The Coming Storm, and much harder to patrol. As well as a flat salt marsh, the territory contains a rocky beach filled with shellfish, a dangerous bog, and a small flooded forest with dead trees. Prey is less abundant, but there's more areas to hunt.

## Trivia

* When it was first created, Marshclan was known as Blizzardclan. The theme was completely changed from a tundra to a marsh to make it more realistic right before the creation of Adventures in Bayclan
* Comparable to Hufflepuff from Harry Potter
Mutation

Missense

Nonsense

Framework

Insertion

Deletion

## Loss-of-function mutations

Amorphic (null) = complete loss of gene function

Hypomorphic = partial loss of gene function, as result in reduction in gene expression or reduced protein/enzyme performance

Haploinsufficient = haploid dose of gene not sufficient for normal gene function

Antimorphs, a.k.a. dominant negative = oppose normal activity; dimeric protein consisting of one normal and one mutated protein no longer functional
Humoral immunity

Involves antibodies.

## Primary response

IgM is the main Ab isotype produced in primary infection. It is found in the blood.

## Secondary response

Involves improved response due to T cell help to create antibodies.

Note that the lack of improved response upon secondary immunization is characteristic of a T cell independent Ab response.

Key preferred characteristics include:

* Shorter lag time post-immunization before Ab responses are detectable
* Increased peak magnitude of the Ab response over the primary response
* Long-lasting increase in antibody titers
Empire City

In the DJMutt universe, Empire City is the most populous city of United Territories, with 12,349,856 residents in 2015.

## Buildings

* Empire Tower, equivalent to Tokyo Tower
* Petronas Towers, equivalent to Petronas Towers in Malaysia
* Tower of Time, equivalent to Burj Khalifa in Dubai
* 230,000 resident buildings

## Attractions

* Amethyst Avenue, equivalent to Las Vegas Strip
* Broadway Street, the name says it all
* Grand Wizard Gate, equivalent to Brandenburg Gate
* Millifest, equivalent to Piccadilly Circus
* Quartz Redeemer, equivalent to Christ Redeemer
* Sapphire Oval Garden, equivalent to Madison Square Garden
* Squared Circle, equivalent to Arc de Triomphe
* SubTube, the subway system

## Places

### Stores

* Merch Mall, equivalent to Walmart (25 operations)
* Disney/Warner Bros/Paramount/Universal Stores (10 operations each)
* Animal House, pet adoption store (17 operations)
* Spoiled Brats, pet supplies store (15 operations)

### Restaurants

* ALB Pearl's, equivalent to TGI Friday's (23 operations)
* BraZillion, equivalent to Chipotle (12 operations)
* McDonnie's, equivalent to McDonald's (28 operations)
* Panucci's Pizza, a pizzeria (4 operations)
* Namtrac's Coffee, a coffeehouse (4 operations)
* Tweek Bros. Coffee, a coffeehouse (HQ in 59th St)

### Schools

* Southern Border Elementary, kindergarten to 5th grade (225 students)
* Hopefest School, 6th to 10th grade (672 students)
* Supreterra, 8th to 10th grade (336 students)

### Other

* Alamo Drafthouse Cinema, the name says it all (7 operations)
* Teletoon, a TV bumper company (HQ in Amethyst Av)
* Teletoon at Night, a cinematic Teletoon (3 operations)
Somatic recombination

Somatic recombination occurs during D → J gene rearrangements and V → DJ gene rearrangements.

### RAG-1/2 bind either side of the selected gene segment and recruit other DNA repair enzymes

Recombination signal sequences (**RSS**) that flank V, D and J segments are recognized by enzymes (**RAG-1/2)** involved in cutting and rejoining the gene segments. An RSS contains a conserved nonamer sequence and heptamer sequence separated by a spacer sequence either of either 12 bp or 23 bp. To ensure that segments are brought together in the correct order, an RSS with a 12-bp spacer is always paired with one with a 23-bp spacer (**12/23 rule**).

### 2 RSSs are aligned

Pairs heptamers together and nonamers together.

### DNA is cleaved at random sites, forming a hairpin on each end

Splicing is imprecise.

Intervening DNA is cut out. Its ends are joined, forming a signal joint, then it is sent to be degraded.

Chromosomal DNA is ligated by DNA repair enzymes, forming a coding joint.

### Generation of junctional diversity

Palindromic (**P**) nucleotides are added depending where the enzyme cuts into the hairpin.

**TdT** adds non-templated (**N**) nucleotides, generating diversity although frameshift mutations and/or stop codons may be introduced.

### Ends are ligated together

The exonuclease of DNA repair enzymes removes nucleotides that do not complementary base pair.

Gaps are filled in by DNA synthase and DNA ligase seals gaps.
Positive and negative selection (T cell)

αβ T cells are subject to positive and negative selection prior to leaving the thymus. The goal is to allow the survival of T cells that can dock MHC but do not recognize self-peptide.

## Positive selection

Cortical epithelial cells test whether a TCR can dock with a self-MHC protein.

## Negative selection

Medullary epithelial cells select against self-reactive T cells by testing whether a TCR binds MHC/self-peptide too strongly.
Cytotoxic T lymphocyte

Effector CD8 T cells (CTLs) recognize peptide bound to MHC class I.

## Activation

Requires 3 signals:

1. TCR : MHC I-peptide + co-receptor engagement
2. CD28 : B7.1/.2 signalling (co-stimulation)
3. Requirement for additional IL-2

In some cases, a CD4 T cell being activated by the same DC can provide additional IL-2.

## Differentiation

The differentiation process involves changes in the expression of adhesion molecules to allow entry to infection sites. Effector CD8 T cells express high levels of CD2 and LFA-1.

## Killing

When an effector CD8 T cell recognizes MHC I-peptide, LFA-1 undergoes a conformational change to bind more tightly to ICAM-1 on the infected cell. Effector CD8 T cells do not need co-stimulation to function.

The CTL releases granules to direct the infected cell to undergo apoptosis rather than cell lysis. This ensures that only the target cell is killed, and not healthy bystander cells or the CTL itself, and that no new virus particles are released as the target cell is being killed.

Infected cells that have undergone apoptosis are then phagocytosed by macrophages. CTLs also secrete IFN-γ to stimulate nearby macrophages so the latter can phagocytose more effectively.
Lean On Me

## Plot

A tomboy named Bebe and her best friend Clyde cosplay as superheroes and roleplay saving the world from harm.

On an overnight trip, the duo get lost in a cosplay convention during a snack break. Clyde teams up with Marvel superboy cosplayers, and Bebe teams up with DC supergirl cosplayers. Even when they're not together, they'll make it out alive.
Agammaglobulinemia

A primary immunodeficiency disorder - low/absent serum antibodies and low/absent circulating B cells.

Most congenital cases are X-linked form (XLA). Other patients have autosomal recessive form (ARA).

Some cases due to hypomorph mutation that hampers but not completely abolish B cell development and function.

XLA = defect in Btk, involved in downstream signalling of pre-BCR or BCR

ARA = defect in BCR or downstream signalling molecules (BLNK, an adaptor protein)

### Treatment

Ig injections, either monthly intravenous (IVIG) or weekly subcutaneous (SCIg). IVIG contains polyclonal IgG from pooled human plasma donations.
Laila

Laila is the love interest of Cirrus, and sometimes, the leading female of Bolt fanfics.

## History

Laila used to be a Junkyard dog back in NYC, but she left to be with someone else. That someone else turned out to be Cirrus, who was a playful dude.

Attraction was immediate, but love took time, and pretty soon, they loved each other. They now live together in Sacramento, California.
Adam Ateer

Adam Ateer is a student of Hope's Peak Academy and a participant in the Discordronpa V3 Killing Game.

His talent is the Ultimate Analyst.

## Prologue

Adam woke up in the pool room with Yuuko Pyua and Kaguya Ono.

Eventually, he met with the rest of the cast and was greeted by the very handsome Monokuma in the gymnasium, where it was announced the students would have to murder each other in order to escape. Adam was not very fond of this idea.

## Chapter 1

Despite Monokuma's mean-spirited threat, Adam remained calm. He still held trust in everyone and was sure they would be rescued by authorities if they just waited long enough. He theorized that the best possible way to strengthen everyone's bond was through a bonfire party, the idea also formed with the help of Jake Eldon and Atsuko Kurohi. Unfortunately, the bonfire party was a failure, with less than half of the students making an appearance. Things got worse when they discovered the corpse of their classmate Maemi Aomame in the chemistry lab; this truly was the worst day ever.
Cappo Comico

Cappo Comico is a student of Hope's Peak Academy and a participant in the Discordronpa V3 Killing Game.

His talent is the Ultimate Clown. He is Italian.

## Prologue

Cappo first woke up in the gymnasium with Jennifer Claire, Kazuya Omori, and Naoki Kobayashi. He acted friendly and polite to everyone, often cracking jokes, mimicking others, and juggling various objects. Eventually, he found himself back in the gym where Monokuma announced the beginning of the Killing Game. The information shocked him so much he stayed in the gym for hours.
Oliver & Company

The second-worst animated movie produced by Disney, after The Black Cauldron.

## Why it sucks

1. It tries to be an adaption to Oliver Twist, but it ends up being a ripoff to the 1982 film *Annie*.
2. It's a dull cash-grab, even though the producers thought they were making a classic.
3. There was no reason to set it in 1980s NYC, there's nothing wrong with producing two feature-length movies in a row set in London. More specifically, **1830s London.**
4. Straight-up insulting to the people who live in both London and New York.
5. It tries so hard to be the 1968 film *Oliver*but it fails miserably.
6. PRODUCT PLACEMENT. Must I say more? I mean, Reese's Pieces were in *ET* but at least they were subtle enough!
7. Incredibly insensitive to 9/11, as the film treats the Twin Towers as if they were built by Jesus. It's insulting to the viewers, it's insulting to children's intelligence, and it's straight-up insulting to the people who died in 9/11. That's like saying nobody died on the Titanic!
8. The protagonist is a KITTEN. How much am I gonna say I HATE cats? In reality they EAT MICE, who were the main characters in Disney's other film, *The Great Mouse Detective*. Also I've learned in my life that cats are NO FUN.
9. Why do stories with orphans NEED AN ANTAGONIST?! Shouldn't the STREETS be the actual villain? Sykes does almost NOTHING for the film and is a totally unnecessary character.
10. And speaking of villains, Disney stereotyped Dobermans by making them aggressive! Dobermans in real life are very friendly and they do NOT deserve this reputation!
11. Dodger tries to sing, but instead he ends up screaming his lines. His song? VERY ANNOYING.
12. Wastes the voice talents of everyone who voiced the film's characters, the voices are wooden and Joey Lawrence is so squeaky even though HE'S THE OLDEST OF HIS BROTHERS.
13. Jenny Foxworth is Daddy Warbucks because she's a millionaire AND SHE ADOPTS THE ORPHAN.
14. Charley Bates is missing from the film. If he was in the film, where would he have been?
15. What's with the abandoned kittens? Are the producers so cruel and just throw them out, and make the remaining kitten forget all about it? Or did they know this film was gonna be hated?
16. The characters are so dumb, they never think twice on ANYTHING. Also they never. Stop. TALKING.

## Redeeming qualities

1. The chorus of Dodger's song in the Brazilian Portuguese dub is good.
2. Cheech Marin was praised being Tito and he would later on be casted as Banzai in *The Lion King*.
3. It's slightly better than *The Black Cauldron*. No blood, no extreme violence, no intense horror.

## My review

Faux Annie ripoff is weak, unfunny, boring, charmless and forgettable. A complete waste of time.
Jack Kind Of Had To Die

Angry that he died?

Well, here the reasons how Jack died was kind of relevant.

## So this is why he died

1. From the looks of it, there is **no way**he and Rose would've balanced on that plank togther. They would've been dangling on it, with 80% of their body in the freezing water. Then they would've **both**died.
2. Everyone is arguing there was **plenty**of room on that plank. The truth is... some people were greedy, unfortunately including ROSE.
3. TBH, if he lived, that would make the film itself **less memorable.**To keep the emotions strong, Jack died so he and Rose would reunite some eight decades later.

So yeah. Jack had to die.

"Let it go"
Jennifer Claire

Jennifer Claire (or "Taylor") is a student of Hope's Peak Academy and a participant in the Discordronpa V3 Killing Game.

Her talent is the Ultimate Tailor.

## Chapter 0

As the students awakened in the school, Jennifer found herself in the gymnasium. Uninterested in conversation, she spent her time investigating the room until the doors unlocked.

Ostracized for her abrasive personality and terse speech, Jennifer quickly became antagonized by students around her.
Atsuko Kurohi

Atsuko Kurohi is a student of Hope's Peak Academy and a participant in the Discordronpa V3 Killing Game.

Her title is the Ultimate Arsonist.

## Prologue

Atsuko woke up in the dining room with Maemi Aomame. A little later, she left to meet the rest of the students, a little aggressively, before being informed by Monkouma that they were all taking part in a Killing Game.

## Chapter 1

Atsuko was unamused by the bear's threat and shrugged it off as some joke. She came up with the idea that it was all some reality show and that no one was in any harm and kept that mindeset throughout the following days. Though aggressive with a few of the students, she befriended a lot of them, and got very close with Cappo Comico one night in the showers. Along with Jake Eldon and Adam Ateer, she came up with the idea of the bonfire party for everyone to meet up and have fun. Her knowledge with fires proved useful when setting up the pit and organizing the party. Although roughly half the students showed up, she had fun and danced with Cappo. Unfortunately, the parade was rained on when the sprinklers went off at the end of the party, sending everyone out of the gym. Soon after, she arrived at the chemistry lab to find out Maemi was murdered.
Memory cells

Memory is an important aspect of adaptive immunity.

During the early stages of infection, effector cells outnumber memory cells. As the infection subsides, memory cells outnumber effector cells.

## Secondary response

During secondary responses to the same antigen, memory cells are preferentially activated over naive cells for they...

* Outnumber naive cells
* Do not need constant rescue from apoptosis
* Easier to activate
* Have undergone affinity maturation, thus have higher affinity BCR for pathogen (B cell)
* Don't express inhibitory receptor FcγRIIBI (B cell)
	+ When Ag-Ab complexes bind to this receptor, initiates apoptosis in naive B cell
	+ Ensures immune response targeted to produce high affinity Abs by memory cells
* Express higher levels of MHC II and co-stimulatory molecules (B cell)
* Do not need co-stimulation for activation (T cell)

## Memory B cells

### Distinguishing different types of B cells

* Low IgM, high IgD
* Membrane Ig
* Likely to have isotype-switched
* Membrane Ig (could be IgM; more likely IgG, IgA or IgE - no IgD)
* Expression of CD27
* Lots of ribosomes, ER, large Golgi apparatus
* No membrane Ig

## Memory T cells

### Distinguishing different types of T cells

More challenging. Combinations of cell surface markers are used to identify memory T cells

CD45 is a tyrosine phosphatase that dephosphorylates Lck. It is found in all hematopoietic cells, except erythrocytes and plasma cells.

* Express CD45RA and CD45 RB
* Express CD45RO, which transduces strong signals from the TCR
* Does not express CD45
Akira Shimizu

Akira Shimizu is a student of Hope's Peak Academy and a participant in the Discordronpa V3 Killing Game.

His talent is the Ultimate Conspiracy Theorist or Conspiracist.

## Prologue

Akira first woke up in the library alongside Rika Yurei and Mayumi Ichikawa. After being let out of the room, they met the other students before being made aware of the Killing Game by Monokuma in the gymnasium.

## Chapter 1

Akira first reacted to the idea of the Killing Game by making several different random ringleader predictions, including the government, the Russians, and even aliens. These ideas were mostly scoffed at. Despite seeming to be an introverted character, he spent some time getting to know his classmates. A lot of his time was spent with Rika, and bouncing ideas back and forth with Maemi Aomame in an effort to figure out the intentions of both Monokuma and some of the other students. He spoke in vague terms about whether or not he would attend the bonfire party, but when the time came he was nowhere to be seen. He showed up to the crime scene in the chemistry later that night, however, to discover his peer Maemi's deceased body.

The absolute state
Boys X Girls (Pound Puppies)

## Summary

Ginger is a girl puppy with tough masculine behavior, while Stevie is a boy puppy with cute feminine behavior. Cooper think something is wrong with them, but Revvy tries to assure him that it's just their choice for personality.

## Trivia

* The episode was critically praised due to sexual equality and freedom of tomboyism/effinemacy.
Maemi Aomame

Maemi Aomama is a student of Hope's Peak Academy and a participant in the Discordronpa V3 Killing Game.

Her talent is the Ultimate Journalist.

She's a seemingly trusting person, with the goal to unite everyone and keep everyone safe. She serves as the heart of the group and definitely doesn't raise death flags by trying to protect everyone.

She was the first victim in the killing game.
Cinque Notti con Cinzio

***Cinque Noites con Cinzio***is the Italian edition of ***Five Nights at Freddy's***.

## Characters (Personaggi)

* Cinzio Orso (Cinzio Bear) = Freddy Fazbear
* Conglino (Little Bunny) = Bonnie
* Pollina (Chicken) = Chica
* Volp Pirata (Fox Pirate) = Foxy

## Entries (Inserimenti)

### Games (Giochi)

1. Cinque Notti con Cinzio = September 4, 2014
2. Cinque Notti con Cinzio 2 = December 7, 2014
3. Cinque Notti con Cinzio 3 = March 31, 2015
4. Cinque Notti con Cinzio 4 = August 15, 2015
5. Il Mondo di CNcC = February 18, 2016
6. Cinque Notti con Cinzio: Posizione Junior = November 4, 2016
7. Simulatore Pizzeria di Cinzio Urso = December 20, 2017
8. CNcC: Massimo Notte Personalizzata = July 15, 2018

### Novels (Romanzi)

1. L'Occhi D'Argento = February 9, 2016
2. L'Distortini = August 4, 2017
3. L'Armadio di Segreti = August 5, 2018

## Phone calls (chiamate telefoniche)

### FNAF 1

#### Night 1

Benvenuti in Cíntio Urso Pizzeria, un luogo magico per tutte le età, dove la fantasia e il divertimento prendono vita, bla bla bla...
Ottoman Empire - reunited today

## Information

* Population: 426 million (3rd)
* Size: about same size as Australia
* Capital: Constantinople (Turkey territory) (Constantinople is imaginary)
* Largest city: Instanbul (Turkey territory)
* GDP (nominal): 3.675 trillion (5th)
* Military: 8.1 million (1st)

## Religions

* Islam (64%)
	+ Sunni Islam (56%)
	+ Shia Islam (8%)
* Christianity (22%)
* Judaism (2%)
* Atheism (3%)
* Other (9%)

## Languages

1. Arabic
2. Turkish
3. Kurdish
4. Romanian
5. Greek

## Largest cities

1. Instanbul
2. Cairo
3. Baghdad
4. Ankara
5. Alexandria
6. Giza
7. Izmir
8. Jeddah
9. Alger
10. Bucharest
11. Chisinau
Kara Patronsker

**Kara Patronsker**is a fan-made *South Park* character created and owned by me, DJMutt. Feel free to use her, just as long as you credit me. Thanks!

## Information

* Species: human
* Race: Caucasian
* Weapons: her soccer ball
* Sex: female
* Age: 12
* Outfit: bright blue hooded sweater, underneath a bright green shirt, navy blue pants, green shoes
* Accessories: yellow panting dog on bright green shirt
* Birthday: April 14
* Handedness: left
* Height: moderate
* Hair: hazel
* Eyes: chocolate brown
* Occupation: seventh grader at South Park Education
* Status: alive
* Relatives: the Patronsker family
* Pets: Oliver (black lab), Damian (grey kitten)
* Friends: Butters (love interest), Stan, Kyle, Kenny (close friends), Clyde, Kevin, Craig, Tweek, Token (normal friends), Cartman (friend-rival)
* Rivals: Cartman (occasionally)

## Relationships

* Butters: he is her love interest. After she saved him from teenage bullies, he couldn't thank her more and they have been together ever since.
* Stan: he's one of her closest friends. Since she's older than him, she refers to him as "kid" to show her affection.

## Trivia

* Kara is inspired by her creator (DJMutt).
* Her family is Brazilian, so she celebrates Brazilian culture and is fluent in the Portuguese language.
Mariana Torres

## Information

* September 8, 1977 (age 41)
* Sex: Female
* Birthplace: São Paulo, Brazil
* Residence: São Paulo
* Nationality: Brazilian
* Occupation: Voice actress
* Active: 1986-present

## Filmography

### Films

* Olivia Flaversham in *Peripécias do Ratinho Detetive* (The Great Mouse Detective) (1986)
* Jenny Foxworth in *Oliver e sua Turma* (Oliver & Company) (1988)
* Anne-Marie in *Todos os Cães Merecem o Céu* (All Dogs Go to Heaven) (1989)
* Edmond in *Chanticler: O Rei do Rock* (Rock-A-Doodle) (1991)
* Mindy in *Bob-Esponja: O Filme* (The Spongebob Squarepants Movie) (2004)
* Ravena (Raven) in *Jovens Titãs: Missão Tóquio* (Teen Titans: Trouble in Tokyo) (2007)
* Kendra in *Libra Cachorros: O Grande Cãofusão* (Pound Puppies: The Long-Lost Puppy) (2017)

### Programs

* Manteigas (Butters) in *Sul Parque* (South Park) (1997-2019)
* Ravena (Raven) in *Jovens Titãs* (Teen Titans) (2003-2007)
* Pérola (Pearl) in *Steven Universo* (Steven Universe) (2003-2010)
* Kendra in *Libra Cachorros* (Pound Puppies) (2012-2020)
Favela (Greatest Films)

## Characters

* Marina Carondos - an 18-year-old Brazilian woman who helps out the favela.
* Antonio - Marina's new friend who is the favela manager and wants to make a change.
* Claudio - Antonio's uncle who is the charge for murders in the favela.
* Dominicus - a Fila Brasileiro (Brazilian mastiff) and Marina's pet dog.
* Alessandra and Carla - Marina's older and younger sisters respectively.

## Why is it great?

1. Brazilian culture is depiected accurately:
	1. The Portuguese language (its official language), a jaguar (its official animal), brigadeiros (its traditional candy) and the Brazilian National Anthem are all included.
	2. Marina points out how dangerous favelas are and what we people can do to save them.
	3. Dia do Finados is about dedicating and celebrating people in the Afterlife.
2. Marina is a very adventurous and likable protagonist.
3. Strong, touchful scenes, like when Antonio dies of hemorrhaging while Marina looks on.
4. Claudio is a legitimately scary villain.
5. Some funny moments, such as at the street fair when Dominicus chases a rat who is stealing meat from him.

## Bad thing

1. Dominicus can be annoying to some people.
Ed, Edd N Eddy characters portrayed by 1987 TMNT

"Ed, Edd N Eddy characters portrayed by 1987 TMNT" is a set of pics portrayed by characters from the 1987 TMNT.

Ed portrayed by Michelangelo.Edd portrayed by Donatello.Eddy portrayed by Raphael.Sarah portrayed by Shredder (Featuring April O'Neil)Jimmy portrayed by Baxter Stockman (featuring Shredder)Kevin portrayed by Casey JonesJohnny 2X4 and Plank portrayed by Slash.Rolf portrayed by the accordian player from the episode, "The Case of the Killer Pizzas" (featuring April O'Neil)Nazz portrayed by April O'Neil (featuring Leonardo, Donatello, Raphael, & Michelangelo)The Kanker sister portrayed by human versions of Rocksteady, Bebop, & the street punks.Matthew (B.K.A. Eddy's Brother) portrayed by Lord Dregg.
Jatekfold Resimler

**Jatekfold Resimler**(English translation is "Toy Pictures") was a Turkish animation studio located in Bursa and was active from 1982 to 2000. It was known for its low-budget knockoffs to animated films of the 1980s and 1990s, especially Disney and Don Bluth.

## Portfolio

### *Foxes and Hounds*(1983)

* Turkish title: *Tilki ve Tazi*
* Mockbuster of: *The Fox and the Hound*

### *Mice Sorcerers* (1984)

* Turkish title: *Fareler Buyuculer*
* Mockbuster of: *The Secret of NIMH*

### *Mouse Detective* (1988)

* Turkish title: *Fare Detekfiti*
* Mockbuster of: *The Great Mouse Detective*

### *Afterlife, According to Dogs*(1990)

* Turkish title: *Olenler, Kopeklere Gore*
* Mockbuster to: *All Dogs go to Heaven*

### *Beast and Me* (1993)

* Turkish title: *Canavar ve Ben*
* Mockbuster of: *Beauty and the Beast*

### *Tiger Prince*(1996)

* Turkish title: *Kaplan Prens*
* Mockbuster of: *The Lion King*

### *The King of Egypt*(2000)

* Turkish title: *Misir Krali*
* Mockbuster of: *The Prince of Egypt*
Mujer

## Lyrics

Mujer

Mujer!

Mujer

Oh, mujer!

Ladies are the best species in history

And we ain't playin

Don't you abduct us queens

That's what I'm sayin

They don't think it, but we're the best

We're Number One

We're better than males

Yo, holdin the bun!

What can make you move?

Mujer!

Can ya feel the groove?

Mujer!

What can make you slide?

Mujer!

Oh, mujer!

Mujer!
Cartoon Network Will Get Sued

December 4, 2017

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAHHHHHHHHHHH!!!

(That was me SCREAMIN!)

I can't believe how ruined my childhood is. And the whole Sesame Street mocking isn't even part of this.

Basically, I thought Sesame Street was mocked too much. But when I looked at a clip for a spinoff TV special to The Amazing World of Gumball, I realized I was wrong.

You see, Cartoon Network had mocked Dora the Explorer. Great, now all we need to do is have a South Park episode about Dora the EXPILICT, am I right folks...oh wait never mind. Dora was on the episode Taming Strange. If Ike was watching Sesame Street, it would've been the end of the road for my love of South Park.

And now I can't wait until Cartoon Network gets sued by Nick Jr, who might as well tell them that Nickelodeon is the best animation channel out there.

You see, Dora was a part of my childhood, and I don't know why it's so popular in spoofing. Basically, I now hate Gumball. And yeah, just like South Park, it mocks everything, but Gumball is the one crossing the line without using any profanities.

CN took all the charm of Dora and completely flushed it down the toilet. Just like Sesame Street, I watched Dora as a toddler and saw it till I was about seven. When my sister introduced me to South Park, I became a huge fan because of its humor, colorfulness and it's always looking on the bright side.

(don't ask me how I got to watch South Park at nine years old, my parents didn't give a fuck. But also because my sister loves it)

I swear, if you have the balls to do a Dora the Explorer mock, try ruining everyone's childhood by getting the balls to do a Sesame Street mock.
Marco Diaz

Marco Diaz is the leading male of most *Star VS the Forces of Evil* media.

## Information

* Created by: Daron Nefcy
* TV appearances: *Star VS the Forces of Evil*by Disney XD
* Other appearances: A Stendy Story
* Full name: Marco Stephen Olivier Diaz

## Relatives

### Normal media

* Parents, but no name given to them
* Star Butterfly (either girlfriend or wife; depends on timeline)
* Olwen (daughter; depends on timeline)

### A Stendy Story

* Sportacus (deceased uncle)
* Star Diaz (wife)
* Wendy Tester Diaz (daughter)
* Steven Olivier Diaz (son)
* Oliver Stephen Diaz (son)
* Olwen Maggie Diaz (daughter)
* Robbie Rotten (deceased uncle)