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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun May 31, 2015 04:24 AM

Quote | Reply

On May 30, 2015 3:37 AM mahkcots wrote:

Do you know their names?
Yes, but because those are not advertising 3BP treatments on their webpage I cannot share their names in public. I can give you the details on private msg. if you need that. But why do you need the info?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun May 31, 2015 12:45 PM
Quote | ReplyDoes anyone have an opinion on the combiniation DCA and paracetamol?

The third patient in the article below had a good response to IV DCA. However, it is not clear whether he was taking paracetamol at the same time as IV DCA.

The IV 3-BP and paracetamol produced a metabolic cure in the melanoma patient after two treatments.

http://www.ncbi.nlm.nih.gov/pubmed/25362214
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun May 31, 2015 12:46 PM
Quote | ReplyYes, I agree. Treatment at centres outside of first world nations such as America and Germany would have to beconsidered carefully.

It is also worth pointing out that there is now quite a trade in 3-BP through Chinese sellers. For example, what is being called Pharmaceutical Intermediate 3-BP is now on sale (99% purity).

http://www.alibaba.com/showroom/3--bromopyruvate.html

http://www.molbase.com/en/search.html?search\_type=text&s
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun May 31, 2015 01:37 PM
Quote | ReplyIt is quite remarkable how much of the 3-BP how purity product is being offered for sale. Does anyone know whether this high quality 3-BP has only recently been marketed? There appears to be substantial production capacity for it. The site noted above has suppliers offering product with minimum orders of 1 kilogram.

I wonder if some of these suppliers would offer products more aimed at the consumer level. For example, perhaps they could create pills of say 10 mg 3-BP with very high chemical purity and detailed chemical descriptions. Such a description might be able to provide assurance that  any contaminant had been determined to not be harmuful to human health.

Another idea of product they could aim at the consumer would be a sterile IV 3-BP product. Perhaps such a product could contain the whole set-up for a sterile IV administration. For example, an IV bag, a dose of 3-BP, places to add water etc. .
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### RE: Anyone used 3bp (3-bromopyruvate)?

by mahkcots on Mon Jun 01, 2015 11:14 PM
Quote | ReplyPlease do send me a private message. Because I am looking for the best treatment option. All of the literature says an iv is not the best method for curing liver metastasis and im hoping there are places in Germany that i can go to.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Tue Jun 02, 2015 01:53 AM
Quote | ReplyI just sent a response. Btw, are you looking for a place where they perform chemoembolisation using 3BP? If that is the case, you probably want to contact Prof Vogl and ask if he can help with that.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Tue Jun 02, 2015 02:30 PM

Quote | Reply

On May 31, 2015 4:45 PM Jcancom wrote:

Does anyone have an opinion on the combiniation DCA and paracetamol?

The third patient in the article below had a good response to IV DCA. However, it is not clear whether he was taking paracetamol at the same time as IV DCA.

The IV 3-BP and paracetamol produced a metabolic cure in the melanoma patient after two treatments.

http://www.ncbi.nlm.nih.gov/pubmed/25362214 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/25362214 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/25362214
Here is the full PDF http://alternative-therapies.com/at/web\_pdfs/S202Khan.pdf  Its hard to say about glutathione http://www.ncbi.nlm.nih.gov/pubmed/15386533  http://www.hindawi.com/journals/omcl/2013/972913/  Its hard to say if paracetamol will help or not
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Tue Jun 02, 2015 07:49 PM
Quote | ReplyDCA has made me so weak I spent 2 hrs getting out of the tub today.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Wed Jun 03, 2015 03:43 PM
Quote | ReplyLate to the party here. Does anyone have a suggestion as to how to obtain a 3BP IV? Certainly no one I know would give it, not even our naturopaths specializing in oncology.

### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Wed Jun 03, 2015 03:53 PM
Quote | ReplyDayspring in AZ
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Wed Jun 03, 2015 03:54 PM

Quote | Reply

On May 24, 2015 8:55 PM kcervantes wrote:

Daniel -

I think this would be an amazing opportunity for so many cancer patients!  Especially the ones who conventional treatment has failed and have no where else to turn.
For many of us, particularly those who have failed conventional (rubbish) tx, time is of essence. And $. Dayspring is charging a huge amount, which for us is out of the question. Why does something like this take so long (rhetorical Q of course). Trying to get hold of the clinic in Germany but so far no luck. I just emailed Dr. Ko.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Wed Jun 03, 2015 04:07 PM

Quote | Reply

On Jun 03, 2015 7:43 PM Moonlitnight wrote:

Late to the party here. Does anyone have a suggestion as to how to obtain a 3BP IV? Certainly no one I know would give it, not even our naturopaths specializing in oncology.
Hi Moonlitnight, I gave some details in some of the previous posts on how we do the IVs. Please read that and if you have questions let me know.

In anycase, the 3BP that is used for IV can be bought as powder at purity >97% from chemical suppliers. (This is not sterile, so after mixing with water for injection or saline, it is filtered with a 0.2um sterile filter for serynge.)
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Wed Jun 03, 2015 04:10 PM

Quote | Reply

On Jun 03, 2015 7:54 PM Moonlitnight wrote:

On May 24, 2015 8:55 PM kcervantes wrote:

Daniel -

I think this would be an amazing opportunity for so many cancer patients!  Especially the ones who conventional treatment has failed and have no where else to turn.
For many of us, particularly those who have failed conventional (rubbish) tx, time is of essence. And $. Dayspring is charging a huge amount, which for us is out of the question. Why does something like this take so long (rhetorical Q of course). Trying to get hold of the clinic in Germany but so far no luck. I just emailed Dr. Ko.
As I know, dr. Ko doent reply. I wil send to you on private (due to the reason I mentioned) some contact details of clinics in Germany doing 3BP.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jun 03, 2015 04:11 PM
Quote | ReplyIt looks like someone might be interested in the crowdfunding idea. Does anyone know how to private message with Facebook? Do you have to disclose emails publically?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Wed Jun 03, 2015 04:13 PM

Quote | Reply

On Jun 02, 2015 11:49 PM Genelle wrote:

DCA has made me so weak I spent 2 hrs getting out of the tub today.
Genelle, I havent heard of such side effects from DCA. How much and how often are you taking that, and what form? IV and oral or IV ony?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Wed Jun 03, 2015 04:16 PM

Quote | Reply

On Jun 03, 2015 8:11 PM Jcancom wrote:

It looks like someone might be interested in the crowdfunding idea. Does anyone know how to private message with Facebook? Do you have to disclose emails publically?
Hey Jcancom! Just be yourself. Disclose your email :D
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Wed Jun 03, 2015 04:16 PM

Quote | Reply

On Jun 03, 2015 8:07 PM Danielus wrote:

On Jun 03, 2015 7:43 PM Moonlitnight wrote:

Late to the party here. Does anyone have a suggestion as to how to obtain a 3BP IV? Certainly no one I know would give it, not even our naturopaths specializing in oncology.
Hi Moonlitnight, I gave some details in some of the previous posts on how we do the IVs. Please read that and if you have questions let me know.

In anycase, the 3BP that is used for IV can be bought as powder at purity >97% from chemical suppliers. (This is not sterile, so after mixing with water for injection or saline, it is filtered with a 0.2um sterile filter for serynge.)
My apologies, I missed this. I've been wading through this and the Inspire threads...so many pages. Will go back and track it down.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jun 03, 2015 04:25 PM
Quote | ReplyDanielus posted the IV 3-BP details on Sunday March 29 at 1:37 PM.

You could use the find function with the below url if you like.

http://3bromopyruvate.wikia.com/wiki/Full2
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Wed Jun 03, 2015 04:39 PM
Quote | ReplyThey say it is the max dose for IV and more than the max dose If i were doing pills.

### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Wed Jun 03, 2015 04:56 PM
Quote | ReplyThank you very much Jcancom.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Wed Jun 03, 2015 05:23 PM

Quote | Reply

On Jun 03, 2015 8:39 PM Genelle wrote:

They say it is the max dose for IV and more than the max dose If i were doing pills.
I hear of max such as 100mg/kg IV.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Wed Jun 03, 2015 05:42 PM

Quote | Reply

On Jun 03, 2015 9:23 PM Danielus wrote:

On Jun 03, 2015 8:39 PM Genelle wrote:

They say it is the max dose for IV and more than the max dose If i were doing pills.
I hear of max such as 100mg/kg IV.
I look forward to learning which German clinic is offering 3-BP Daniel, AND, I just discovered that there is a Toronto clinic already providing it for "solid tumours." I am not sure what this means and they have gone home for the day. Are mets defined as "solid tumours"? This clinic also offers low dose chemotherapy and is populated by MDs as well as NDs.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Wed Jun 03, 2015 05:52 PM
Quote | ReplyHey Jcancom, we are at page nr. 100 and reaching 1000 comments on this thread. Let's celebrate :D
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jun 03, 2015 06:08 PM
Quote | ReplyYes, I think a celebration is definitely in order! We are really starting to pick up some steam around here.

Toronto clinic offering 3-BP? Would that be Medicor? I checked their website, though I did not see any reference to 3-BP treatment. They did have a photo op with the discoverers of 3-BP.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Wed Jun 03, 2015 06:28 PM
Quote | ReplyIt would have helped if I included a link! http://cancerimmunotherapycentres.com/your-frist-visit.php
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Wed Jun 03, 2015 06:32 PM
Quote | ReplyI am wondering if they also charge Dayspring rates since their consultation is $350 or thereabouts. I hate it when websites are full of typos as well, Doesn't create confidence. I will go check these docs out.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Wed Jun 03, 2015 06:36 PM
Quote | ReplyTypical treatment cost is approximately $1,200- $1,500 per week. This cost can change depending upon what treatments are used. Whatever treatments are offered to our patients the cost is always of concern, both to us and our patients, and this is discussed before any treatment is given. The rationale for the treatment modality is also discussed with the patient. Most lab investigations and studies are covered through health care, but certain lab investigation(s) are not covered by OHIP. In addition, the cost of supplements, vaccines or other custom made treatments for the patient are NOT included in the cost.

Please be advised that the cost of IPT/ Low Dose Chemotherapy costs from $700 per treatment (depending on which reagents are used), and does NOT include the price of the chemotherapy medication itself.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jun 03, 2015 06:39 PM
Quote | ReplyWow!! "Over the years we have also started to provide intra-tumoral"3-Bromo-pyruvate"injections."

They are really starting to come out of the woodwork. No one else has talked about 3-BP direct tumor injections before!! Wonder if they could set people up with IV 3-BP. It would be interesting if they have any patient reports.

They have been doing this for years? We really need to start asking around a bit more. It would be great if someone got on the horn and found out about Medicor.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Wed Jun 03, 2015 06:40 PM
Quote | ReplyAnd 1000! :)
Quote | Reply

# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jun 03, 2015 06:50 PM
Quote | Reply1001 here!! Woo-HOO!

Thanks everyone for making this such a great thread. It is such an honor for me to be here on the frontlines of a cure for cancer. We are just going from strength to strength. If you look back on the start of this thread there were years!!! without posts! Now it is hard to find days without thread activity.

Let's make the next 1000 even better!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Wed Jun 03, 2015 06:55 PM
Quote | ReplyShould we have the next 1000, on 3BP or should we start another one with the title: "Anyone used Salinomycin?" or "Anyone used Triptolide?"
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Wed Jun 03, 2015 07:03 PM
Quote | ReplyBtw, we now have to realize that just half an year ago everyone was considering using 3BP difficult and dangerous since you need to buffer according to the patents, etc ... and where are we now? We know how to prepare it at home and we know many clinics that can administrate 3BP for us! Offcourse, I still think that a part of the magic is in 3BP and the other part is in knowing how to use it to get the best out of it.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jun 03, 2015 07:07 PM
Quote | ReplyI am just worried that I will be evicted from the thread and cast away to my own private thread: Anyone want to post to Jcancom?

A fair few of those first 1000 posts are mine. If anyone thinks I should post less, then I'll just lurk quietly. I like this thread!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jun 03, 2015 07:29 PM
Quote | ReplyDoes anyone know of a directory for the world's alternative cancer clinics? There probably are not that many. Perhaps they have an association or an annual meeting. It might be a fairly small group.

If we knew who all the players were, we could check out their websites and find out which ones offer 3-BP. Otherwise, it is quite hit and miss finding the 3-BP providers.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Meech90 on Wed Jun 03, 2015 09:42 PM

Quote | Reply

On Jun 03, 2015 10:39 PM Jcancom wrote:

Wow!! "Over the years we have also started to provide intra-tumoral"3-Bromo-pyruvate"injections."

They are really starting to come out of the woodwork. No one else has talked about 3-BP direct tumor injections before!! Wonder if they could set people up with IV 3-BP. It would be interesting if they have any patient reports.

They have been doing this for years? We really need to start asking around a bit more. It would be great if someone got on the horn and found out about Medicor.
I emailed Medicor last night as I live in the Toronto area but haven't received a response yet. I emailed their generic address for general inquiries but they also have the head of the clinic's email address listed so I will try that tomorrow if no response is received.

I specifically asked if they offer 3-BP treatment.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Meech90 on Wed Jun 03, 2015 09:50 PM
Quote | ReplySolid tumours are sarcomas, carcinomas, and lymphomas. As far as I know, it excludes things like leukemia as that's a blood linked cancer and not 'solid'. Metastasis would be solid tumors depending on if the diagnosed cancer fits this criteria.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Meech90 on Wed Jun 03, 2015 09:51 PM

Quote | Reply

On Jun 03, 2015 9:42 PM Moonlitnight wrote:

On Jun 03, 2015 9:23 PM Danielus wrote:

On Jun 03, 2015 8:39 PM Genelle wrote:

They say it is the max dose for IV and more than the max dose If i were doing pills.
I hear of max such as 100mg/kg IV.
I look forward to learning which German clinic is offering 3-BP Daniel, AND, I just discovered that there is a Toronto clinic already providing it for "solid tumours." I am not sure what this means and they have gone home for the day. Are mets defined as "solid tumours"? This clinic also offers low dose chemotherapy and is populated by MDs as well as NDs.
Solid tumours are sarcomas, carcinomas, and lymphomas. As far as I know, it excludes things like leukemia as that's a blood linked cancer and not 'solid'. Metastasis would be solid tumors depending on if the diagnosed cancer fits this criteria.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jun 03, 2015 10:14 PM
Quote | ReplyIt is great that the people are also coming out of nowhere. I guess everyone was waiting for us to make it to 1000 before they jumped on board. Welcome everyone! We can all make our own contributions on this thread.

It seems that 3-BP is approaching a breakthrough moment. Many clinics have probably been sitting back waiting for the early adopters to take the risk and get everything worked out. Well, we are approaching the one year mark of alternative clinic use of 3-BP. It seems that many patients and clinics are realizing that 3-BP is for real. When this point of collective consciousness is truly reached, 3-BP could experience a wave of demand.

This is great news about asking whether Medicor will offer 3-BP treatment! We would be quite interested in knowing the answer. Last time one of the members of the thread asked them they said they had never heard of 3-BP. That was before we discovered the photo on their website in which they appeared to be super schmoozing with the Hopkins discoverers of 3-BP. If they do not want to make a public disclosure that is OK as well.

Does anyone know whetherCancer Immunotherapy Centers is in fact plural or are they looking forward to future growth. Medicor also uses the plural, though there appears to be only one Medicor. I suppose Centers/Centres sounds more important than Center.Centre .
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Meech90 on Thu Jun 04, 2015 12:13 AM
Quote | ReplyI'm wondering if anyone's been able to find any information about the "Cancer Treatment Institute ofColombia"?

I know that they've claimed to have cured a Stage IV SCLC patient but finding any information on this clinic seems a tough task. I'd like to potentially be able to get in contact with them but I haven't been able to find anything about the institute whatsoever online. The press release also claims that a case report has been published on the patient but I haven't been able to find anything except the press release about this particular case.

Thus far, I believe I've only read two published case reports on human use of 3BP. One was the hepatocellular carcinoma patient in Germany, and the other was the melanoma patient in Egypt. Are there any more results? I see Dayspring claims that one patient was cured of metastatic breast cancer and that a metastatic pancreatic cancer patient is well on his way as well; although I do trust it, there don't appear to be case reports. I'm also wondering how many patients this Dayspring has treated in total with 3BP, and why those results haven't been posted.

I'm very hopeful for this treatment so I'd like to see some of these things substantiated.
Quote | Reply

# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jun 04, 2015 12:32 AM
Quote | ReplyThat is the problem that we have all been grappling with for all these months. There are only two well documented patients after 15 years! Each of these patients had a different treatment route: the liver patient had TACE (intra-arterially to the liver) and the melanoma patient had IV 3-BP and then combined with paracetamol. Only the liver patient received treatment for about 10 months, the melanoma patient for only 2 months.

There are other reports, though they are very brief. Dayspring mentioned some patient outlines. Columbia Institute has an extremely low profile on the internet. Johns Hopkins website mentions two other liver cancer patients that had a good response to treatment, though provides no details. The Toronto clinic is now talking about intra-tumoral injections of 3-BP over the last few years. It would so great if there were a legal mechanism available that could force disclosure-- Freedom of Information Request?

Members of this thread and others appear to be moving towards disclosing 3-BP results. This would be amazing, as none of the patient reports so far have been prospective. The concern is that the patients reported have been selected for their enormous responses-- others who might have been treated with lesser results probably were never published.

For example, with the liver patient, once ethics approval was granted they immediately gave a dose of 250mg 3-BP TACE. I do not believe it is conceivable that this would have been done unless they had already treated another patient and knew such a dose was safe.

So, basically yes two patients- two different routes. It is completely outrageous after 15 years. It appears that if action is not taken, then this will continue indefinitely.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Thu Jun 04, 2015 01:07 AM

Quote | Reply

On Jun 04, 2015 4:32 AM Jcancom wrote:

That is the problem that we have all been grappling with for all these months. There are only two well documented patients after 15 years! Each of these patients had a different treatment route: the liver patient had TACE (intra-arterially to the liver) and the melanoma patient had IV 3-BP and then combined with paracetamol. Only the liver patient received treatment for about 10 months, the melanoma patient for only 2 months.

There are other reports, though they are very brief. Dayspring mentioned some patient outlines. Columbia Institute has an extremely low profile on the internet. Johns Hopkins website mentions two other liver cancer patients that had a good response to treatment, though provides no details. The Toronto clinic is now talking about intra-tumoral injections of 3-BP over the last few years. It would so great if there were a legal mechanism available that could force disclosure-- Freedom of Information Request?

Members of this thread and others appear to be moving towards disclosing 3-BP results. This would be amazing, as none of the patient reports so far have been prospective. The concern is that the patients reported have been selected for their enormous responses-- others who might have been treated with lesser results probably were never published.

For example, with the liver patient, once ethics approval was granted they immediately gave a dose of 250mg 3-BP TACE. I do not believe it is conceivable that this would have been done unless they had already treated another patient and knew such a dose was safe.

So, basically yes two patients- two different routes. It is completely outrageous after 15 years. It appears that if action is not taken, then this will continue indefinitely.
That cherry picking aspect has always been my concern. I read books like Life Over Cancer, where there are many examples of patients who were given, say, a month, by some other doctor and are now 10 or 15 years on. Maybe there are 10 such examples. What about all the other scores of patients who have attended the specific cancer centre written about? I have been a medical writer for over 30 years. I have seen patients and written their stories, but I have always asked, "What about the others?" There are always mumblings and excuses and "patient confidentiality" responses. Is this whole 3-BP thing smoke and mirrors? I don't know. I had read aboiut it some time ago then read Tripping Over the Truth, but I wonder where the truth lies.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Thu Jun 04, 2015 01:08 AM
Quote | ReplyEeow. No edit function and a typo.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Meech90 on Thu Jun 04, 2015 01:15 AM
Quote | ReplySelective reporting is my main issue as well. By the way, one of the doctors mentioned in the Colombia article as working on the 3BP therapy which cured the SCLC patient: http://www.newhopeforcancer.org/index.html  Dr. Mark Rosenberg. I assume he would be someone to contact. Not sure if this has been posted before.Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterGenelle

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Thu Jun 04, 2015 01:17 AM
Quote | ReplyMaybe people on this thread will do it and report
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Thu Jun 04, 2015 01:22 AM
Quote | ReplyDr Rosenberg told me 3BP is dangerous. It will be interesting to hear more
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Thu Jun 04, 2015 12:04 PM

Quote | Reply

On Jun 04, 2015 5:22 AM Genelle wrote:

Dr Rosenberg told me 3BP is dangerous. It will be interesting to hear more
Genelle, are you a patient of Dr. Rosenberg? I thought he was a fan of 3-BP.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Thu Jun 04, 2015 01:47 PM
Quote | ReplyNot a patient but I accidently got his cell number. I was surprised to hear him say that.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Thu Jun 04, 2015 01:50 PM
Quote | ReplyDanielus, My doctor is putting my symptoms on her doctor site and taking me off DCA for now. These are not symptoms we expected but I am on a high dose. I am also going for a scan.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Thu Jun 04, 2015 01:56 PM

Quote | Reply

On Jun 04, 2015 5:50 PM Genelle wrote:

Danielus, My doctor is putting my symptoms on her doctor site and taking me off DCA for now. These are not symptoms we expected but I am on a high dose. I am also going for a scan.
Genelle, I havent hear of such symptoms from DCA while knowing many people taking 70-80mg/kg IV. But maybe it was your reaction special. If I would be you, I would certainly like to know what was the dose. Why not lower the dose?Actually, I have the feeling that you went relatively fast to the "very high dose" you mentioned, or maybe I am wrong?

# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Thu Jun 04, 2015 02:00 PM

Quote | Reply

On Jun 04, 2015 5:47 PM Genelle wrote:

Not a patient but I accidently got his cell number. I was surprised to hear him say that.
I think I am getting these guys mixed up. Isn't he involved with that Colombian clinic? He wrote a very good guest article about the American health system and chemo on one website. I was impressed until he said he woke up at 3 am because the truth had suddenly hit him...it was the cells' environment that caused cancer, not mutational events (paraphrased by me). Seriously, I have been reading and writing about this for over 10 years. All the quantum guys have discussed it and written books on it (Bruce Lipton, Gregg Braydon) and Seyfried and Pederson, not to mention Ko have been promoting this POV. Even the much maligned, now deceased, Andreas Moritz, wrote about it in Cancer is Not a Disease, it's a Survival Mechanism. There is also a researcher in Australia who has promoted this POV, based on research, for a number of years.

That kind of put me off. If he had written, "I sat up at 3 am with one thought in my mind: They were right," then I could accept it more. I hate deception as it pulls down the rest of what the author is saying.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Thu Jun 04, 2015 02:01 PM

Quote | Reply

On Jun 04, 2015 5:22 AM Genelle wrote:

Dr Rosenberg told me 3BP is dangerous. It will be interesting to hear more
Did he said why? Is this the reason why it is so rapidly addopted by the private clinics across the world?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Thu Jun 04, 2015 02:03 PM

Quote | Reply

On Jun 04, 2015 6:01 PM Danielus wrote:

On Jun 04, 2015 5:22 AM Genelle wrote:

Dr Rosenberg told me 3BP is dangerous. It will be interesting to hear more
Did he said why? Is this the reason why it is so rapidly addopted by the private clinics across the world?
Daniel, it IS dangerous. Very dangerous...

...for cancer cells.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Thu Jun 04, 2015 02:07 PM
Quote | ReplyDanielus, The doctor did titrate but at 1st I had no response. Later I should have said something before I did. I think my dose was higher than 70 to 80. I will find out FRI.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Thu Jun 04, 2015 02:10 PM

Quote | Reply

On Jun 04, 2015 6:03 PM Moonlitnight wrote:

On Jun 04, 2015 6:01 PM Danielus wrote:

On Jun 04, 2015 5:22 AM Genelle wrote:

Dr Rosenberg told me 3BP is dangerous. It will be interesting to hear more
Did he said why? Is this the reason why it is so rapidly addopted by the private clinics across the world?
Daniel, it IS dangerous. Very dangerous...

...for cancer cells.
Yes ... I agree ... but I was wondering what is behind his statement. There is something and that is not reated to 3BP beeing dangerous. I am confident about that based on all science, case reports and personal experience on 3BP. So why he would say that?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Thu Jun 04, 2015 02:14 PM
Quote | ReplyOk, let me share something very interesting and new to me that I only found today:

SMCT1 has been identified as responsible for DCA uptake, with high affinity (Babu et al., 2011) but it is epigenetically silenced in most tumour cells (Ganapathy et al., 2005), which could explain why high DCA concentrations should be used to achieve cytotoxicity in cancer cells http://repositorium.sdum.uminho.pt/bitstream/1822/32518/1/ba

Maybe some of you knew this before but to me this is new and so interesting. Now lets see if we find ways to upregulate SMCT1!

If we can find that, then that may be a way to incraese DCA effectivness, or alternativey, lower the dose of DCA.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Thu Jun 04, 2015 02:17 PM
Quote | ReplyOK I do not feel well but will try to anwer. I called and he said I got the number from an old site. He said he will not do 3BP anymore. He also said he had worked with Dr Ko. My local oncologist tried for a long time to get UCLA to do a 3BP trial. They would not and he said it was toxic. Strange since it has been approved by the FDA and chemo is toxic. Somethig here does not jive.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Thu Jun 04, 2015 02:20 PM
Quote | ReplyIn the interest of sharing information I will let you all know the outcome.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Thu Jun 04, 2015 02:23 PM

Quote | Reply

On Jun 04, 2015 6:17 PM Genelle wrote:

OK I do not feel well but will try to anwer. I called and he said I got the number from an old site. He said he will not do 3BP anymore. He also said he had worked with Dr Ko. My local oncologist tried for a long time to get UCLA to do a 3BP trial. They would not and he said it was toxic. Strange since it has been approved by the FDA and chemo is toxic. Somethig here does not jive.
Thanks Genelle and feel better soon. My thoughts are with you. I just hate it when oncologists and others call some innocuous substance or plant "toxic" or "dangerous" and then prescribe chemo or radiation (my husband's immune response was destroyed by injected radiation, which also caused widespread inflammation and release of ferritin - two things cancer just loves. I think a lot of these guys just diss what other clinics are doing for the sake of it. At the cancer agency up here, the egos - and contradictory opinions - are so vast that it is hard to get through the doors (not that you'd ever want to...)
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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Thu Jun 04, 2015 02:26 PM
Quote | ReplyIve been researching DCA and found that caffeine improves its effectiveness greatly.  The study stated the patients were drinking caffinated black tea, green tea and coffee 6-7 cups a day. Also vitamin B1 helped as well

http://www.thedcasite.com/dca\_dosage.html

# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Thu Jun 04, 2015 02:27 PM
Quote | ReplyI have a problem because I cannot get advice on some of what I do from drs
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Thu Jun 04, 2015 02:29 PM
Quote | ReplyThanks kcervantes. The prob is not effectiveness. It is side effects
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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Thu Jun 04, 2015 02:32 PM
Quote | ReplyGenelle -

The DCA site has alot of useful information regarding managing side effects too.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jun 04, 2015 02:34 PM
Quote | ReplyGet well soon!

"our findings suggest that combining DCA with a DNA methylation inhibitor would offer a means to reduce the doses of DCA to avoid detrimental effects associated with high doses but without compromisingantitumoractivity."

Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate.

I think we are starting to gain some understanding about what is meant by "toxic". For example, methylglyoxal was for decades widely understood by the scientific community to be toxic, until they found large amounts of it in Australian honey (Manuka honey up to 700 mg/kg). These toxicity claims are almost always an easy out for them because they know that no one can refute the statement, so their credibility is not open to criticism. 3-BP is a synthetic chemical that almost no human has ever been exposed to; the claim of toxicity for 3-BP is thus at least plausible. However, a type of honey that has been existed for 20 million years is likely not toxic.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Thu Jun 04, 2015 02:35 PM
Quote | ReplyThanks kcervantes. I would indeed use those + alfa lipoic acid. But even in that case, DCA may not work for all.

And the questions is why. Some say taht it may be becasue the cancers cells in those people do not have a working mito. In that case, tehre is nothing to do but just stop DCA and switch to e.g. 3BP that may be even more effective if that is the case. But one other obstacle for DCA effectivness seems to be SMCT1 (just as it is MCT1 for 3BP) as mentioned above.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jun 04, 2015 02:37 PM
Quote | ReplyI would think that the best way to avoid side effects is to not try for the maximum possible dose with any one drug.

Combining drugs with similar though not identical mechanisms or with synergies would seem to be the best way. This is why I suggested investigating paracetamol with DCA. It appears that it might have been used in the third patient in the recent article descrbing clinical use of IV DCA.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Thu Jun 04, 2015 02:38 PM

Quote | Reply

On Jun 04, 2015 6:35 PM Danielus wrote:

Thanks kcervantes. I would indeed use those + alfa lipoic acid. But even in that case, DCA may not work for all.

And the questions is why. Some say taht it may be becasue the cancers cells in those people do not have a working mito. In that case, tehre is nothing to do but just stop DCA and switch to e.g. 3BP that may be even more effective if that is the case. But one other obstacle for DCA effectivness seems to be SMCT1 (just as it is MCT1 for 3BP) as mentioned above.
One addition: I would not use so much coffee.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Thu Jun 04, 2015 02:43 PM

Quote | Reply

On Jun 04, 2015 6:38 PM Danielus wrote:

On Jun 04, 2015 6:35 PM Danielus wrote:

Thanks kcervantes. I would indeed use those + alfa lipoic acid. But even in that case, DCA may not work for all.

And the questions is why. Some say taht it may be becasue the cancers cells in those people do not have a working mito. In that case, tehre is nothing to do but just stop DCA and switch to e.g. 3BP that may be even more effective if that is the case. But one other obstacle for DCA effectivness seems to be SMCT1 (just as it is MCT1 for 3BP) as mentioned above.
One addition: I would not use so much coffee.
Much agreed.  And the DCA site kcervantes mentioned, also states better not to use caffeine if one has brain cancer.  Much info on that site--takes time to read--but very informative and worthwhile.

Thanks everyone for the latest updates on so many subjects--and, Genelle, please feel better very soon!  Best to all!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Thu Jun 04, 2015 02:49 PM
Quote | ReplyDanielus, I completely agree that using 3BP can be much more beneficial but DCA is easier to obtain for most people.  Please explain MCT1, as I havent followed the thread completely.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Thu Jun 04, 2015 03:17 PM

Quote | Reply

On Jun 04, 2015 6:49 PM kcervantes wrote:

Danielus, I completely agree that using 3BP can be much more beneficial but DCA is easier to obtain for most people.  Please explain MCT1, as I havent followed the thread completely.
I agree. What I intended to say is that someone can try DCA and if that doesnt work, it may be due to the mito. In that case that person can switch to 3BP and if it is the mito that doesnt work, the chance for 3BP to be effective may be higher. Here it is Kim http://en.wikipedia.org/wiki/Monocarboxylate\_transporter\_1
Quote | Reply

# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Thu Jun 04, 2015 03:25 PM
Quote | ReplyThank you Danielus!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jun 04, 2015 03:25 PM
Quote | ReplyBelow from Role of SLC5A8, a plasma membrane transporter (see article cited above). Surprised we have not heard more of this combination as the drugs noted below are already available.

"DNA methylation plays a critical role in silencing tumor suppressor genes in a variety of cancers, and DNA methylation inhibitors hold promise as anticancer drugs (Baylin, 2005). Two compounds with DNA methylation inhibition activity are in clinical use for treatment of hematologic malignancies. These are 5′-aza-2′-deoxycytidine, also known as decitabine (trade name, Dacogen) and 5′-azacytidine (trade name, Vidaza). In vitro studies have shown that treatment of a variety of cancer cell lines with these compounds re-activates the expression of SLC5A8. We speculate that the same phenomenon would also occur in vivo. Therefore, a combination of a DNA methylation inhibitor and dichloroacetate is likely to be effective for treatment of cancer because the DNA methylation inhibitor would induce the expression of SLC5A8 in tumors, which would then effectively transport dichloroacetate into tumor cells to elicit its antitumor activity. This mode of treatment would reduce considerably the concentration of dichloroacetate necessary for in vivo efficacy as an anticancer agent, thus potentially providing tumor selectivity and also avoiding the detrimental side effects such as neuropathy.

"Monocarboxylate transporters (MCTs) belong to a family of  of transporters, encoded by the SLC16 genefamily, which is presently composed by 14 members. ... MCT1-4 have been demonstrated to facilitate the transmembrane proton-linked transport of metabolically important monocarboxylates such as lactate, pyruvate,branched-chain oxoacids, and the ketone bodies acetoacetate and β-hydroxybutyrate . ..."

This is relevant for 3-BP treatment as MCT-1 is a major transporter of 3-BP into the cell and phenyl butyrate increases expression of MCT-1 (see thread post of  Sun May 17, 2015 08:18 AM)
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Thu Jun 04, 2015 03:30 PM

Quote | Reply

On Jun 04, 2015 7:25 PM kcervantes wrote:

Thank you Danielus!
Allways welcome Kim!

And Butyrate comes back: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811868/

Based on this, Butyrate (which can be found as a supplement in Only shops, e.g. Sodium Butyrate) not only helps 3BP and Artemisinin effectivness but can also help DCA effectvness! But it smels so bad ... :)
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Thu Jun 04, 2015 03:31 PM

Quote | Reply

On Jun 04, 2015 7:25 PM Jcancom wrote:

Below from Role of SLC5A8, a plasma membrane transporter (see article cited above). Surprised we have not heard more of this combination as the drugs noted below are already available.

"DNA methylation plays a critical role in silencing tumor suppressor genes in a variety of cancers, and DNA methylation inhibitors hold promise as anticancer drugs (Baylin, 2005). Two compounds with DNA methylation inhibition activity are in clinical use for treatment of hematologic malignancies. These are 5′-aza-2′-deoxycytidine, also known as decitabine (trade name, Dacogen) and 5′-azacytidine (trade name, Vidaza). In vitro studies have shown that treatment of a variety of cancer cell lines with these compounds re-activates the expression of SLC5A8. We speculate that the same phenomenon would also occur in vivo. Therefore, a combination of a DNA methylation inhibitor and dichloroacetate is likely to be effective for treatment of cancer because the DNA methylation inhibitor would induce the expression of SLC5A8 in tumors, which would then effectively transport dichloroacetate into tumor cells to elicit its antitumor activity. This mode of treatment would reduce considerably the concentration of dichloroacetate necessary for in vivo efficacy as an anticancer agent, thus potentially providing tumor selectivity and also avoiding the detrimental side effects such as neuropathy.

"Monocarboxylate transporters (MCTs) belong to a family of  of transporters, encoded by the SLC16 genefamily, which is presently composed by 14 members. ... MCT1-4 have been demonstrated to facilitate the transmembrane proton-linked transport of metabolically important monocarboxylates such as lactate, pyruvate,branched-chain oxoacids, and the ketone bodies acetoacetate and β-hydroxybutyrate . ..."

This is relevant for 3-BP treatment as MCT-1 is a major transporter of 3-BP into the cell and phenyl butyrate increases expression of MCT-1 (see thread post of  Sun May 17, 2015 08:18 AM)
Thanks, Jcancom. Very good link and explanation of MCT.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Thu Jun 04, 2015 05:09 PM
Quote | ReplySo are you no longer suggesting combining 3BP and Paracetamol?  But 3BP and Butyrate instead?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Thu Jun 04, 2015 05:29 PM

Quote | Reply

On Jun 04, 2015 9:09 PM kcervantes wrote:

So are you no longer suggesting combining 3BP and Paracetamol?  But 3BP and Butyrate instead?
No, Paracetamol stays as it is used to address Gluthadiole (i.e. reduce) while Butyrate is used to address the transporters (i.e. upregulate). Note: I would not use Paracetamol continuously due to the toxicity - instead cycles.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jun 04, 2015 06:08 PM
Quote | ReplyEarlier the question was asked: Is 3-BP actually effective or are the results that we have discussed largely been about selection effects ? From the evidence that we have compiled over almost the last year on this thread, it is reasonably clear to me that 3-BP is in fact quite effective.

The authors of the liver cancer report were unequivocal:

"The rate of tumor necrosis due to 3BP treatment seems to exceed all known cytostatic drugs."

[Am I the only one that noticed? The liver cancer article is now behind a paywall! There must have been quite a few downloads going on! http://link.springer.com/article/10.1007%2Fs10863-012-9425-4  ].

Furthermore, as I noted earlier as a thought experiment on the thread:  What would you expect would happen if you treated someone with cancer with a pyruvic acid analog? [This would disrupt the cellular respiration pathway and should stress cancer cells.] If you go to the chemicalize.org " target="\_blank" rel="nofollow">chemicalize.org  website and type in pyruvic acid and ask for all similar molecules you find that almost all of the 130 or so chemicals that have 20 or more pages associated with them have anti-cancer effects ( including 3-BP and MG ). Not surprisingly DCA and 3-BrOP (which is a chemical similar to 3-BP being devleped by MD Anderson) also have anti-cancer properties. Given this result from the chemicalize.org " target="\_blank" rel="nofollow">chemicalize.org  site it would be surprising if 3-BP did not have anti-cancer properties.

Another point to keep in mind is that there were likely not many other patients similar to the liver cancer patient treated with 3-BP through official medical channels. There has not been much selection involved. The number of hospitals that would be willing to do this procedure (especially at that time around 2011) would be small. Importantly the Hopkins people had to go to Germany to even find one patient that could be treated. Decisions regarding treatment might have required input from federal regulators in Germany. If there had been earlier unsuccessful attempts, this would probably have been known to them.

With alternative medicine unsubstatiated claims can always be made: many of which are never published in generally accepted journals. One suspects that in many instances the people "cured from cancer" never had cancer in the first place. There can be no doubt that the liver cancer patient had cancer.

Given this, it is very disappointing that 3-BP has been in limbo for so many years. It is likely that the liver cancer patient is at the very worst a 1 in ten outcome. Yet, mainstream medicine had absolutely nothing left to offer. Why are so many cancer being offered treatments that have a 0.0% chance of success when they could be offered a treatment with at a minimum 10%?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Thu Jun 04, 2015 06:17 PM
Quote | ReplyExcellent post Jcancom. I will be speaking with my husband's oncology naturopath as apparently, he was approached (this is third party info) by someone at a conference and offered the whole 3-BP thing at astronomical cost which he felt was not serving patients in any way. He also felt there was not enough evidence to justify providing it as a service. He does DCA, Vit C + artesunate (there's a good one) and various immune-boosting therapies. I will get more info on how he was approached and by whom and post it.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Thu Jun 04, 2015 10:08 PM
Quote | ReplyDanielus, My doctor just called me having received a lot of feedback from the doctor site. She thinks all my symptoms are from DCA so tomorrow I will get fluids and nutrients and vit C IVs. I think I want to go cold turkey and do 3BP. Will email you later as I am so tired.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Meech90 on Fri Jun 05, 2015 12:53 AM
Quote | ReplyI have gotten in touch with Medicor and they do not provide 3BP treatments as they have not attained government approval to administer such a treatment. They do however have similar treatments (DCA). They are definitely aware of the treatment as the basics of it and how it relates to DCA was discussed in the reply to my email. The email was directly from Dr. Khan.Quote | Reply

# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Fri Jun 05, 2015 02:34 PM

Quote | Reply

On Jun 05, 2015 4:53 AM Meech90 wrote:

I have gotten in touch with Medicor and they do not provide 3BP treatments as they have not attained government approval to administer such a treatment. They do however have similar treatments (DCA). They are definitely aware of the treatment as the basics of it and how it relates to DCA was discussed in the reply to my email. The email was directly from Dr. Khan.I spoke with Dr. Gagovski of cancer immunotherapy centres of Tto. They offer 3-BP IVs at $370 a pop with suggested regimen of 2 or 3x weekly for 12 weeks. You would have to stay in Tto for three months if you didn't live there.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Fri Jun 05, 2015 03:25 PM
Quote | ReplyThis is super awesome! (even better than our 1000th post party!) Woo-Hoo, Woo Hoo!

Given the risk aversive nature of Canada, it seems fair to say that 3-BP is transitioning toward mainstream acceptance. It now should be expected that many clinics worldwide that had been sitting on the fence on 3-BP will step forward.

And the price point that the TO clinic is offering is almost unbeatable. That is 370 Canadian pesos! We should all pray for lower oil prices and that 370 could be even more affordable in US dollars. Currently, that 370 Canadian would be less than US $1000 for three treatments. Per injection pricing should make this an easy decision for patients. Patients now do not have to face the grim option of trusting the hygienic or chemical purity standards of a third world nation for 3-BP treatment. Within a modern industralized nation, such behaviors would offer legal recourse (though perhaps not the 3-BP treatment itself).

At these prices, paying for treatment through an official clinic is competitive with ordering through a scientific supplier and doing it yourself (considering the strain one would undergo). This move by a Canadian clinic to bring down prices was to be expected but it is a significant development. It will be very interesting to see if/how Medicor responds. It does not seem plausbile that one clinic has been allowed by the governement to provide 3-BP treatment and not Medicor.

Did the clinic mention how long they have been offering treatment?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Meech90 on Fri Jun 05, 2015 03:39 PM

Quote | Reply

On Jun 05, 2015 6:34 PM Moonlitnight wrote:

On Jun 05, 2015 4:53 AM Meech90 wrote:

I have gotten in touch with Medicor and they do not provide 3BP treatments as they have not attained government approval to administer such a treatment. They do however have similar treatments (DCA). They are definitely aware of the treatment as the basics of it and how it relates to DCA was discussed in the reply to my email. The email was directly from Dr. Khan.I spoke with Dr. Gagovski of cancer immunotherapy centres of Tto. They offer 3-BP IVs at $370 a pop with suggested regimen of 2 or 3x weekly for 12 weeks. You would have to stay in Tto for three months if you didn't live there.
Thank you for the information. Is the $370 a weekly cost for 12 weeks or is it ($370\*3)\*12?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Fri Jun 05, 2015 03:47 PM
Quote | ReplyIt is amazing how much the price of 3-BP treatment has now fallen. The Dayspring price was probably around US $3000 per injection, while the Toronto price is now close to US $300.

At this price point, one might expect a very large quantity demanded. For most people such pricing has removed the economic barrier to treatment. It will also be much easier to try some crowdfunding.

Canada has found the sweet spot on the 3-BP risk curve. Even a few months ago, a casual observer trying to sort out the research would have had a difficult task. However, now, even with what has been publically disclosed, a casual observer would probably allow limited 3-BP treatment.  The Canadian government would likely have access to a considerable amount of information about 3-BP that has not been disclosed publically (for example, possibly patient results from clinics using 3-BP).
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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Fri Jun 05, 2015 03:47 PM

Quote | Reply

On Jun 05, 2015 7:25 PM Jcancom wrote:

This is super awesome! (even better than our 1000th post party!) Woo-Hoo, Woo Hoo!

Given the risk aversive nature of Canada, it seems fair to say that 3-BP is transitioning toward mainstream acceptance. It now should be expected that many clinics worldwide that had been sitting on the fence on 3-BP will step forward.

And the price point that the TO clinic is offering is almost unbeatable. That is 370 Canadian pesos! We should all pray for lower oil prices and that 370 could be even more affordable in US dollars. Currently, that 370 Canadian would be less than US $1000 for three treatments. Per injection pricing should make this an easy decision for patients. Patients now do not have to face the grim option of trusting the hygienic or chemical purity standards of a third world nation for 3-BP treatment. Within a modern industralized nation, such behaviors would offer legal recourse (though perhaps not the 3-BP treatment itself).

At these prices, paying for treatment through an official clinic is competitive with ordering through a scientific supplier and doing it yourself (considering the strain one would undergo). This move by a Canadian clinic to bring down prices was to be expected but it is a significant development. It will be very interesting to see if/how Medicor responds. It does not seem plausbile that one clinic has been allowed by the governement to provide 3-BP treatment and not Medicor.

Did the clinic mention how long they have been offering treatment?

A google search for Dr. Gagovski states the clinic is *Permanently closed* and there are no reviews for it. Also the website claims *Over the years we have also started to provide intra-tumoral 3-Bromo-pyruvate injections* http://cancerimmunotherapycentres.com/
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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Fri Jun 05, 2015 03:52 PM
Quote | ReplyIf Dr Khan of the Medicor Cancer Center isn't allowed to do 3BrPA then how come Dr Gagovski is?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Fri Jun 05, 2015 03:53 PM
Quote | ReplyThe Google search does not correspond to the above post that mentioned that the doctor in question was spoken to.

Has the clinic "permanently closed" starting today?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Meech90 on Fri Jun 05, 2015 03:55 PM
Quote | ReplyAlso, for clarification regarding the two known case reports of 3BP patients:

1. Were they clear of disease, according to scans and markers, post-treatment?

2. Did they have metastatic cancer and were the metasteses resolved? I know the melanoma patient had metastases and he underwent IV infusion, which would theoretically attack metastases, but the liver patient appears to have had direct injection into the hepatic artery which I assume would only attack the liver tumor, and not the metastatic sites. I could be wrong on this though, and that's why I'm asking.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Fri Jun 05, 2015 03:56 PM
Quote | ReplyYeah, that did not make sense to me either. Medicor is a leader and their stated philosophy is to offer innovative treatments such as 3-BP, if possible.

The only explanation I could think of, is that Medicor could actually offer 3-BP treatment, though for some unexplained reason decided not to. Blaming government regulation would then be just a convenient out.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Meech90 on Fri Jun 05, 2015 03:59 PM

Quote | Reply

On Jun 05, 2015 7:52 PM james-peters wrote:

If Dr Khan of the Medicor Cancer Center isn't allowed to do 3BrPA then how come Dr Gagovski is?
Maybe approval of treatment by the government is a process which takes some time, and Dr. Gagovski applied for approval long before (as evidenced by the claim that they had been administering 3BP for years). Or maybe Medicor has no interest in administering this type of treatment and haven't even inquired about attaining permission for the treatment.

From the email:

"We do not have permission from the government to administer 3BP"

It doesn't imply that they're seeking permission.
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# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Fri Jun 05, 2015 04:01 PM
Quote | ReplyThe liver patient at last check had no evidence of cancer. They collected a huge amount of fluid from him. They could find no live cancer cells. The scans in the article showed that other tumors also resolved. (I will leave it to other posters to explain how TACE could help with these tumors).

The melanoma patient's LDH was measured near 10 after his second combo treatment. Before treatment it was over 4000. The authors of the article talked of the treatment as being a metabolic cure. They noted that the huge destroyed tumor mass should be understood as being distinct from actually metabollically active disease.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Meech90 on Fri Jun 05, 2015 04:08 PM

Quote | Reply

On Jun 05, 2015 8:01 PM Jcancom wrote:

The liver patient at last check had no evidence of cancer. They collected a huge amount of fluid from him. They could find no live cancer cells. The scans in the article showed that other tumors also resolved. (I will leave it to other posters to explain how TACE could help with these tumors).

The melanoma patient's LDH was measured near 10 after his second combo treatment. Before treatment it was over 4000. The authors of the article talked of the treatment as being a metabolic cure. They noted that the huge destroyed tumor mass should be understood as being distinct from actually metabollically active disease.
I see the melanoma patient also had a 2.5x2.5cm metastasis on the left ventricle. I don't see whether or not this was resolved or not, from reading the case report.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Fri Jun 05, 2015 04:10 PM
Quote | ReplyThe LDH of 10 which might have went to 0 if the patient had suvived should indicate that essentially the entire tumor mass in the patient's body was inactive.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Meech90 on Fri Jun 05, 2015 04:16 PM

Quote | Reply

On Jun 05, 2015 8:10 PM Jcancom wrote:

The LDH of 10 which might have went to 0 if the patient had suvived should indicate that essentially the entire tumor mass in the patient's body was inactive.
Great, thanks for clearing that up!Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterJcancom

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Fri Jun 05, 2015 05:14 PM
Quote | ReplyOh, that is interesting. The Toronto clinic says it will not offer treatment to out of country patients.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Fri Jun 05, 2015 05:47 PM

Quote | Reply

On Jun 05, 2015 7:59 PM Meech90 wrote:

On Jun 05, 2015 7:52 PM james-peters wrote:

If Dr Khan of the Medicor Cancer Center isn't allowed to do 3BrPA then how come Dr Gagovski is?
Maybe approval of treatment by the government is a process which takes some time, and Dr. Gagovski applied for approval long before (as evidenced by the claim that they had been administering 3BP for years). Or maybe Medicor has no interest in administering this type of treatment and haven't even inquired about attaining permission for the treatment.

From the email:

"We do not have permission from the government to administer 3BP"

It doesn't imply that they're seeking permission.
If anyone wants the 3-BP, I wouldn't be making waves about how come such-and-such a clinic can and the other can't. Just quietly go with it and get what you want in case the powers thet be stop it.  Here's what Dr. Akbar says:

We do not administer 3BP because it is not approved for human use in Canada, and the government has not given us permission to use it.

The closest thing we have is a drug called DCA, which works in a similar way to 3BP.

It looks to me like Dr. Akbar is happy with DCA and maybe doesn't even want to administer 3-BP.Someon e back there asked if the $370 was per shot. Yes it is.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Fri Jun 05, 2015 06:33 PM

Quote | Reply

On Jun 05, 2015 9:47 PM Moonlitnight wrote:

On Jun 05, 2015 7:59 PM Meech90 wrote:

On Jun 05, 2015 7:52 PM james-peters wrote:

If Dr Khan of the Medicor Cancer Center isn't allowed to do 3BrPA then how come Dr Gagovski is?
Maybe approval of treatment by the government is a process which takes some time, and Dr. Gagovski applied for approval long before (as evidenced by the claim that they had been administering 3BP for years). Or maybe Medicor has no interest in administering this type of treatment and haven't even inquired about attaining permission for the treatment.

From the email:

"We do not have permission from the government to administer 3BP"

It doesn't imply that they're seeking permission.
If anyone wants the 3-BP, I wouldn't be making waves about how come such-and-such a clinic can and the other can't. Just quietly go with it and get what you want in case the powers thet be stop it.  Here's what Dr. Akbar says:

We do not administer 3BP because it is not approved for human use in Canada, and the government has not given us permission to use it.

The closest thing we have is a drug called DCA, which works in a similar way to 3BP.

It looks to me like Dr. Akbar is happy with DCA and maybe doesn't even want to administer 3-BP.Someon "" target="\_blank" rel="nofollow">http://3-BP.Someon " target="\_blank" rel="nofollow">3-BP.Someon  e back there asked if the $370 was per shot. Yes it is.
But thats the problem, how do we know the clinic in question is legitimate?.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Fri Jun 05, 2015 06:37 PM

Quote | Reply

On Jun 05, 2015 7:53 PM Jcancom wrote:

The Google search does not correspond to the above post that mentioned that the doctor in question was spoken to.

Has the clinic "permanently closed" starting today?
I did a search a few days ago and the "permanently closed" info was up. Also there are no reviews either. However I did find this http://www.cpso.on.ca/public-register/doctor-details.aspx?vi
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Fri Jun 05, 2015 06:49 PM

Quote | Reply

On Jun 05, 2015 10:37 PM james-peters wrote:

On Jun 05, 2015 7:53 PM Jcancom wrote:

The Google search does not correspond to the above post that mentioned that the doctor in question was spoken to.

Has the clinic "permanently closed" starting today?
I did a search a few days ago and the "permanently closed" info was up. Also there are no reviews either. However I did find this http://www.cpso.on.ca/public-register/doctor-details.aspx?vi ew=1&id=%2056041"" target="\_blank" rel="nofollow">http://www.cpso.on.ca/public-register/doctor-details.aspx?vi  target="\_blank" rel="nofollow">http://www.cpso.on.ca/public-register/doctor-details.aspx?vi
Where does it say "permanently closed" James? I can't see that anywhere. I must be losing it.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Fri Jun 05, 2015 06:52 PM
Quote | ReplyIf you click on the Practice Locations and Professional Corporations tab and look at the Medical Record Locations heading it says: "Location Not Available (available only if physician has ceased practising in Ontario and provided a medical records location)."

Therefore, he must continue to be practising medicine in Ontario.
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# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Fri Jun 05, 2015 06:55 PM

Quote | Reply

On Jun 05, 2015 10:52 PM Jcancom wrote:

If you click on the Practice Locations and Professional Corporations tab and look at the Medical Record Locations heading it says: "Location Not Available (available only if physician has ceased practising in Ontario and provided a medical records location)."

Therefore, he must continue to be practising medicine in Ontario.
That is how I read it as well.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Fri Jun 05, 2015 06:57 PM
Quote | Reply...except I forgot the andcondition (and provided a medical records location).
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Fri Jun 05, 2015 07:50 PM
Quote | ReplyIf the clinic were not legitimate, I would not expect that they would advertise that they "have treated patients with 3-BP for years" (paraphrase). They could always have done it under the table and there would have been little notice.

The comment from Medicor seems odd. They are not treating with 3-BP because it is not approved in Canada (and the government has not given them permission to use it)? None of their treatments have been approved!

The best way to understand the Toronto clinic offering 3-BP is the government wants to gradually gain confidence in the treatment and then it can move up the altrnative cancer clinic food chain (or the other clinics want to hedge for a while to let everything settle out).

It would be interesting to know how long they have been treating with IV 3-BP.

This is very good news. As 3-BP moves into different regulatory environments, there might be an opportunity to demand disclosure of patient outcomes through some sort of a legal mechanism such as a Freedom of Information request. If that were to happen, we could finally start to see some significant numbers of sequential, intent to treat patient reports. I wonder if there is a website that would give details of the government approval for the 3-BP treatments.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Meech90 on Fri Jun 05, 2015 08:35 PM
Quote | ReplyIt seems that the "cancer as a metabolic disease" movement has gained a good deal of traction. Here's a study from three months ago on antibiotics which target the mitochondria eradicating cancer stem cells, which has implications for controling metastasis:

http://www.ncbi.nlm.nih.gov/pubmed/25625193
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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Fri Jun 05, 2015 08:40 PM

Quote | Reply

On Jun 05, 2015 11:50 PM Jcancom wrote:

If the clinic were not legitimate, I would not expect that they would advertise that they "have treated patients with 3-BP for years" (paraphrase). They could always have done it under the table and there would have been little notice.

The comment from Medicor seems odd. They are not treating with 3-BP because it is not approved in Canada (and the government has not given them permission to use it)? None of their treatments have been approved!

The best way to understand the Toronto clinic offering 3-BP is the government wants to gradually gain confidence in the treatment and then it can move up the altrnative cancer clinic food chain (or the other clinics want to hedge for a while to let everything settle out).

It would be interesting to know how long they have been treating with IV 3-BP.

This is very good news. As 3-BP moves into different regulatory environments, there might be an opportunity to demand disclosure of patient outcomes through some sort of a legal mechanism such as a Freedom of Information request. If that were to happen, we could finally start to see some significant numbers of sequential, intent to treat patient reports. I wonder if there is a website that would give details of the government approval for the 3-BP treatments.
DCA and naltrexone are approved in Canada and in many other countries for human use. DCA has medical uses for removing warts and other skin growths. Researchers have also tested it on humans for decreasing lactic acidosis (lactic acid buildup), hypertension and metabolic diseases. Naltrexone is used primarily in the management of alcohol dependence and opioid dependence. So any Dr can write an *off-label* prescription, which is legal. If the government has given them the ok then it would be hoped that they have a legal document to prove it, or other paper work
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Fri Jun 05, 2015 09:09 PM
Quote | ReplyThat is true about the off label usage. I was thinking about the quote from their website when they talked about treating with medications that had actually never went through all three phases in any indication. In fact, 3-BP would also be in that category.

From the glacial progress that has occurred at the clinic level with 3-BP, it might never make it through a phase III trial. Perhaps that is why these altrnative clinics are now starting to offer it. It seems pretty clear that interest from the pharmas has been quite subdued. This is unfortunate because 3-BP has never went throught the proper medicinal chemistry development cycle to create a truly optimized product. It is all quite disheartening. If 3-BP does not work out, everything can say I told you so and it would fade into obscurity.

"However, these drugs are unlikely to be approved and marketed as cancer treatments because they may be off patent or not patentable. Without a drug patent, it is difficult to find funds for expensive human trials since the cost of the trials could never be recovered.

Some of the drugs we prescribe have not completed the necessary 3 stages of clinical trials, and are therefore considered “unproven” despite the fact that they have shown good results in preliminary cancer research."
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Fri Jun 05, 2015 10:30 PM
Quote | ReplyDoes anyone have an opinion on the big Nature article that came out in the last few days about a newly discovered link between the lymphatic system and the brain? Does this have any relevance for mets to the brain. Might this be a way for cancer to enter the brain?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jun 06, 2015 10:41 AM

Quote | Reply

On Jun 06, 2015 3:54 AM Jcancom wrote:

We have a Cure

The wehaveacure Facebook page  https://www.facebook.com/TheCancerCure "" target="\_blank" rel="nofollow">https://www.facebook.com/TheCancerCure " target="\_blank" rel="nofollow">https://www.facebook.com/TheCancerCure

has an interesting comment near the top on the left hand side of the page (First Posts to Page embedded).

[See quote below] Who does Dayspring have this non-disclosure arrangement with? I am not sure what is meant by this would be "operating against Federal Rule". Has the government really been so obstructionist that they have prevented Dayspring from bringing attention to their successes with 3-BP? This might explain the truly sad quality of patient disclosures on their website. It seems almost the worst possible outcome that this thread is often marketing for Dayspring when we have almost no idea what their results have been. How exactly would it be inappropriate for Dayspring to disclose sequential intent to treat patient files?

"Dayspring Clinic has a non-disclosure agreement not allowing them to discuss their protocol so they have not in principle accepted to publicize results. They are also bound by the HIPPA laws not to do so without express consent from their patients. Itis up to their individual patients to discuss their experience. We are working with one patient who wants full public disclosure of their results. Dayspring clinic may also be operating against Federal Rule even if what they are doing is legal in their state. There are many campaigns in Indiegogo etc trying to get money for cancer patients and failing. There have been headlines that "we have a cure" for 3 bromopyruvate as well as for many agents who are NOT a cure and you will find many a deaf ear when you try to advertise a concept that the majority of people consider impossible. We welcome your help and ideas. Please, contact us at thecanccercure@outlook.com, not anonymously. Funding agencies have been contacting us and MD's are trying to get treatment for themselves and their loved ones in clinics that can disclose their findings. ONE CAVEAT: Seriously ill patients may be beyond rescue. Yvar Verhoeven was cured of cancer but had only 5% of his liver left when he was allowed to use 3bromopyruvate. Patients need to use a drug that frees them from cancer before their vital organs are rendered useless."
So to summarize, we have the following knowledge re players:

Dr. Ko: No idea what she's up to but she seems to have broken off her relationship with Dr. Rosenberg.

JH: Developed an oral route that will take forever to get to market.

Dr. M. Rosenberg: No longer offering 3-BP and may have called it "dangerous" although we do not know the context. Was involved in the Bogota clinic along with Dr. J. Williams but not any more.Appear s to be high on salinomycin.

Dr. J. Williams: Operates a clinic in Alabama and one in Bogota, both of which deliver 3-BP and possibly also salinomycin in Bogota (although this seems dubious).

Dr. V. Gagovski (cancerImmunotherapy.com): runs a clinic in Ontario that provides 3-BP at $370 CD an infusion and has apparently been doing this for a while.

Dr. A. Khan (Medicor in Ontario) does not offer 3-BP as he is not approved to do so (but has an image of the players at Medicor with Dr. Ko).

The most genuine fellow out of this lot seems to be Dr. Rosenberg. He has a story to tell and I'd love to know what it is.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 06, 2015 12:23 PM
Quote | ReplyYes, it is pretty thin.

Is there a url for the Alabama clinic?

It gets even murkier when we add in  Cytoluminator. He is claiming that he has been treating with a second generation 3-BP for about a year. The figure on his website showing X-Gly depressing body temperature (and thus probably cellular respiration) much more than 3-BP made me more concerned than impressed.

MD Anderson has developed 3-BRoP which is 3-BP with 3 carbons added and this could be moving to the clinic. (It is supposed to be safer and more effective than 3-BP).  An Atlanta clinic is also treating with 3-BP.

The FDA approved Prescience Labs to begin a phase 1 trial with 3-BP two years ago that has yet to start. The FDA has also granted two orphan designations for 3-BP.

http://3bromopyruvate.wikia.com/wiki/7.\_Clinics\_Offering\_3-B

One book that goes into the behind the scenes activity of 3-BP and cancer research is Tripping over the Truth. When I first clicked on the book at the below url most of the book was provided online. The story about 3-BP appears to be truly scandalous. It would be a good book to read along with the book by Cancer as a Metabolic Disease.

http://www.amazon.com/Tripping-Over-Truth-Metabolic-Theory/d
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 06, 2015 12:37 PM
Quote | ReplyQuite a bit of Cancer as a Metabolic Disease can also be accessed online. The foreward was written by a discoverer of 3-BP.

http://www.amazon.com/reader/0470584920/ref=rdr\_sb\_li\_hist\_1
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# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jun 06, 2015 01:31 PM

Quote | Reply

On Jun 06, 2015 4:23 PM Jcancom wrote:

Yes, it is pretty thin.

Is there a url for the Alabama clinic?

It gets even murkier when we add in  Cytoluminator. He is claiming that he has been treating with a second generation 3-BP for about a year. The figure on his website showing X-Gly depressing body temperature (and thus probably cellular respiration) much more than 3-BP made me more concerned than impressed.

MD Anderson has developed 3-BRoP which is 3-BP with 3 carbons added and this could be moving to the clinic. (It is supposed to be safer and more effective than 3-BP).  An Atlanta clinic is also treating with 3-BP.

The FDA approved Prescience Labs to begin a phase 1 trial with 3-BP two years ago that has yet to start. The FDA has also granted two orphan designations for 3-BP.

http://3bromopyruvate.wikia.com/wiki/7.\_Clinics\_Offering\_3-B P"" target="\_blank" rel="nofollow">http://3bromopyruvate.wikia.com/wiki/7.\_Clinics\_Offering\_3-B  target="\_blank" rel="nofollow">http://3bromopyruvate.wikia.com/wiki/7.\_Clinics\_Offering\_3-B

One book that goes into the behind the scenes activity of 3-BP and cancer research is Tripping over the Truth. When I first clicked on the book at the below url most of the book was provided online. The story about 3-BP appears to be truly scandalous. It would be a good book to read along with the book by Cancer as a Metabolic Disease.

http://www.amazon.com/Tripping-Over-Truth-Metabolic-Theory/d p/1500600318#reader\_1500600318"" target="\_blank" rel="nofollow">http://www.amazon.com/Tripping-Over-Truth-Metabolic-Theory/d  target="\_blank" rel="nofollow">http://www.amazon.com/Tripping-Over-Truth-Metabolic-Theory/d
Thanks JCanCom for filling in the gaps. I read Tripping Over the Truth a while back. A singularly well written book IMO and, yes, it is scandalous. Alabama clinic:

http://cancerablation.com/?page\_id=85  Note that I contacted their PR person about 3-BP and she referred me to this site and requested full medical records including a scan on CD fir a review (gratis) before going for a consultation. I see nothing here on 3-BP. Do you?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 06, 2015 01:39 PM
Quote | ReplyNo mention that I could see on the Alabama site of 3-BP.

Perhaps they offer it, though do not advertise it. Would be very good to know whether or not they are providing 3-BP treatment.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jun 06, 2015 02:41 PM

Quote | Reply

On Jun 06, 2015 5:39 PM Jcancom wrote:

No mention that I could see on the Alabama site of 3-BP.

Perhaps they offer it, though do not advertise it. Would be very good to know whether or not they are providing 3-BP treatment.
When I emailed their PR person about 3-BP, I was asked to provide medical records. Dr. Jason Williams would then contact me to discuss 3-BP and immunotherapy protocols. I was then invited to go to the website "to see what protocols Dr. Williams has developed."
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jun 06, 2015 02:42 PM

Quote | Reply

On Jun 06, 2015 6:41 PM Moonlitnight wrote:

On Jun 06, 2015 5:39 PM Jcancom wrote:

No mention that I could see on the Alabama site of 3-BP.

Perhaps they offer it, though do not advertise it. Would be very good to know whether or not they are providing 3-BP treatment.
When I emailed their PR person about 3-BP, I was asked to provide medical records. Dr. Jason Williams would then contact me to discuss 3-BP and immunotherapy protocols. I was then invited to go to the website "to see what protocols Dr. Williams has developed."
I have the records now and am firing them off to Alabama next week.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 06, 2015 03:02 PM
Quote | ReplyI am sure everyone will look forward to the report from the Alabama clinic. Their doctor has actual 3-BP clinical experience. It will be very interesting to hear from their doctor. When I went back to the PRN news wire release of the Columbia results I noticed that the ablation website was given near the bottom.

It is a worry that one of the other Columbia Institute doctors considers 3-BP "dangerous". There are only a few named doctors treating with 3-BP, everyone else is reporting on their results or on second hand gossip.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 06, 2015 03:17 PM
Quote | ReplySince we have a few new thread posters I wanted to add links to some other cancer treatments that I have found especially impressive.

Minicells and X-Ray PDT

-Minicells! Wow, up to 1 million times more effective than straight chemotherapy. Human clinical  trials have been published and are ongoing. It looks like when they optimize the minicells by removing the endotoxin coatng that minicells will deliver curative responses in people. The dosing curve is translating almost exactly from mice to human. Only minor flu like symptoms in the published phase 1 trial.

http://www.ncbi.nlm.nih.gov/pubmed/17482133

http://ac.els-cdn.com/S1535610807000906/1-s2.0-S153561080700

-X-Ray PDT

PDT has mostly shown limited ability to reach tumors. What if you could use X-Rays to reach tumors? The whole body could then be treatable.

http://cen.acs.org/articles/93/web/2015/03/Nanoparticle-Take
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 06, 2015 03:32 PM
Quote | ReplyI see now what was being referred to with the google search yielding "Permanently closed" for the Toronto doctor providing 3-BP treatment.

The google map that is above this shows a clinic at Don Mills and Eglinton. The doctor's new clinic is at the 401 and Mccowan. The doctor seems to move around quite a bit, he seems to be listed at all sorts of other clinics in the Toronto area.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 06, 2015 05:20 PM
Quote | ReplyBad link for the X-Ray PDT. Here itis again

http://cen.acs.org/articles/93/web/2015/03/Nanoparticle-Take
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jun 06, 2015 05:25 PM

Quote | Reply

On Jun 06, 2015 9:20 PM Jcancom wrote:

Bad link for the X-Ray PDT. Here itis again

http://cen.acs.org/articles/93/web/2015/03/Nanoparticle-Take s-Photodynamic-Therapy-Deep.html"" target="\_blank" rel="nofollow">http://cen.acs.org/articles/93/web/2015/03/Nanoparticle-Take  target="\_blank" rel="nofollow">http://cen.acs.org/articles/93/web/2015/03/Nanoparticle-Take
Dr. Rosenberg had a very unpleasant incident with a patient after administering 3-BP (she had SCLC with brain mets). It set up an autoimmune response with swelling in the brain I believe. She survived but was in hospital for a week. Maybe this put him off. He is no longer associated with the Bogota clinic or Jason Williams as far as I can tell.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 06, 2015 05:49 PM
Quote | ReplyThis thread below appears to give the history of the patient in question (Look for the April 11 9:13 am post). The post says she was treated in a Florida clinic by the doctor.

The patient description notes that the there were over 70 brain mets. This would not seem to be the ideal patient to treat with 3-BP. 3-BP is understood not to cross the BBB, though one could imagine that if some did get through with someone with over 70 brain mets that there could be serious side effects. 3-BP is promoted as a universal anti-cancer agent. One of the only probable limitations of 3-BP would be brain mets.

http://www.inspire.com/groups/ovarian-cancer-national-allian
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# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 06, 2015 06:06 PM
Quote | ReplyThe liver patient and the melanoma patient had overwhelmingly severe illness. The liver patient had almost no liver function when he started 3-BP treatment, the melanoma patient had almost no respiratory capacity. Even still they achieved extraordinary levels of anit-tumor repsonse. However, it seems likely that neither had few if any brain mets.

It is possible (though unclear) that a few brain mets might be compatible with 3-BP treatment. However, the patient noted above would not be an ideal candidate. It seems unfortunate that this patient's experience appears to be swaying the perception of 3-BP as much as it is. In almost any clinical trial there are numerous exclusions. Most cancer trials exclude patients with any active brain mets.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jun 06, 2015 06:15 PM

Quote | Reply

On Jun 06, 2015 9:49 PM Jcancom wrote:

This thread below appears to give the history of the patient in question (Look for the April 11 9:13 am post). The post says she was treated in a Florida clinic by the doctor.

The patient description notes that the there were over 70 brain mets. This would not seem to be the ideal patient to treat with 3-BP. 3-BP is understood not to cross the BBB, though one could imagine that if some did get through with someone with over 70 brain mets that there could be serious side effects. 3-BP is promoted as a universal anti-cancer agent. One of the only probable limitations of 3-BP would be brain mets.

http://www.inspire.com/groups/ovarian-cancer-national-allian ce/discussion/1st-stateside-3-bromopyruvate/?reply\_sort=asc&page=7#replies"" target="\_blank" rel="nofollow">http://www.inspire.com/groups/ovarian-cancer-national-allian  target="\_blank" rel="nofollow">http://www.inspire.com/groups/ovarian-cancer-national-allian
Yes...read that. It is possible that this is why Dr. R. said it was "dangerous." I wasn't aware that it didn't cross the BBB...actually never considered that.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 06, 2015 06:23 PM
Quote | ReplyOne of the posters on our thread believes that it does actually cross the BBB. The poster noted that if you put 3-BP into DSMO and put it on the skin you can soon smell the DSMO coming from the head. (I am not totally sure about this, just check on the wikia thread and use the find function with DSMO).

Often in medicine there will be comment...  oh, this wouldn't cross the BBB and then it turns out that it does. It seems plausible that 3-BP would cross the BBB as it is quite a small molecule.

IF 3-BP crossed the BBB and someone had 70 brain mets, I would think that would be quite dangerous. I am not sure how one's brain could cope with all the toxic byproducts that would result from massive tumor destruction. I wonder what lab measurements confirmed that it was an immune reaction
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sat Jun 06, 2015 06:54 PM

Quote | Reply

On Jun 06, 2015 10:23 PM Jcancom wrote:

One of the posters on our thread believes that it does actually cross the BBB. The poster noted that if you put 3-BP into DSMO and put it on the skin you can soon smell the DSMO coming from the head. (I am not totally sure about this, just check on the wikia thread and use the find function with DSMO).

Often in medicine there will be comment...  oh, this wouldn't cross the BBB and then it turns out that it does. It seems plausible that 3-BP would cross the BBB as it is quite a small molecule.

IF 3-BP crossed the BBB and someone had 70 brain mets, I would think that would be quite dangerous. I am not sure how one's brain could cope with all the toxic byproducts that would result from massive tumor destruction. I wonder what lab measurements confirmed that it was an immune reaction
Hey Jcancom, I was "one of the posters" saying that, but not exactly that. You do not smell the DMSO but the specific smel of the combination of DMSO+3BP which is different.

Anyway, via private communication I have received from Dr. Dickens docs with scientific evidence indicating that 3BP can pass BBB, specificaly in cases of starvation. Based on that, I would conclude that in some cases 3BP can pass BBB.

Regarding brain mets, that is always the risk with most of the drugs including DCA. This is why in these cases you want to start at low dose.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 06, 2015 07:14 PM
Quote | ReplyThank you, I knew that it did not quite smell right.

With a patient with 70 brain mets, 3-BP crossing the BBB would be a problem wouldn't it?

What are they referring to when they talk about this as an autoimmune response? That seems surprising to me. It would not seem to me that the body would have an autoimmune response to a pyruvic acid analog: What would happen if someone developed autoimmune responses to pyruvate (i.e the main chemical of glycolysis)?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sat Jun 06, 2015 07:44 PM

Quote | Reply

On Jun 06, 2015 11:14 PM Jcancom wrote:

Thank you, I knew that it did not quite smell right.

With a patient with 70 brain mets, 3-BP crossing the BBB would be a problem wouldn't it?

What are they referring to when they talk about this as an autoimmune response? That seems surprising to me. It would not seem to me that the body would have an autoimmune response to a pyruvic acid analog: What would happen if someone developed autoimmune responses to pyruvate (i.e the main chemical of glycolysis)?
Jcancom, I am not aware of any autoimmune reaction following 3BP administration to humans. In addition, to my knowledge, there is nothing published to support that.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 06, 2015 07:55 PM
Quote | ReplyIt did not make any sense to me either.How  could 3-BP possibly be related to an autoimmune response?

From the Stateside Inspire thread (April 11 9:13 AM).

"We arrived on a Tuesday, had a port surgery on Wed, and our first 3BP treatment that afternoon. Again on Thursday and Friday. My Friday she was not doing well at all. By Sat morning she was almost unresponsive and we spent the next 7 night in a hospital. She has an auto immune response and swelling in her brain."
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Sat Jun 06, 2015 08:07 PM

Quote | Reply

On Jun 06, 2015 11:55 PM Jcancom wrote:

It did not make any sense to me either.How "" target="\_blank" rel="nofollow">http://either.How " target="\_blank" rel="nofollow">either.How  could 3-BP possibly be related to an autoimmune response?

From the Stateside Inspire thread (April 11 9:13 AM).

"We arrived on a Tuesday, had a port surgery on Wed, and our first 3BP treatment that afternoon. Again on Thursday and Friday. My Friday she was not doing well at all. By Sat morning she was almost unresponsive and we spent the next 7 night in a hospital. She has an auto immune response and swelling in her brain."
Speaking about my own experience, I had much difficulty after the port was placed.  I  have trouble with after effects of anesthesia--plus they had problems inserting the port.  The anesthesiologist even said they had to place my head very far back--and the surgeon tried at at least 3-4 times to place the port properly.  The next day I was dizzy and had much difficulty swallowing.  Found out later about many displaced cervical vertebrae and swelling affecting the throat area.  The surgeon thought I should just take anti-anxiety meds.  Could not believe it--I was having physical problems.  Thank goodness for my osteopath who correctly diagnosed the real problems!

I had been scheduled for conventional chemo the following day after surgery--it was cancelled and never went that route then.

More to the story--but just wanted to relate that experience because it is beyond me how and why doctors would want to immediately (next day) do any type of chemo or other treatments--even 3-BP.  Patients are usually fragile at this point.  A short period of time--at least--should be given for them to get over the port surgery and anesthesia.

No wonder there may be autoimmune responses.  Many varied factors combined here to develop such a response--not just the 3-BP itself.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 06, 2015 08:19 PM
Quote | ReplyThey did the port on Wednesday then treated with 3-BP that afternoon and for the next two days! Patient was not doing well on Friday.

This treatment plan would not seem to be advisable.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jun 06, 2015 08:45 PM

Quote | Reply

On Jun 06, 2015 7:17 PM Jcancom wrote:

Since we have a few new thread posters I wanted to add links to some other cancer treatments that I have found especially impressive.

Minicells and X-Ray PDT

-Minicells! Wow, up to 1 million times more effective than straight chemotherapy. Human clinical  trials have been published and are ongoing. It looks like when they optimize the minicells by removing the endotoxin coatng that minicells will deliver curative responses in people. The dosing curve is translating almost exactly from mice to human. Only minor flu like symptoms in the published phase 1 trial.

http://www.ncbi.nlm.nih.gov/pubmed/17482133 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/17482133 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/17482133

http://ac.els-cdn.com/S1535610807000906/1-s2.0-S153561080700 0906-main.pdf?\_tid=dd210350-0c7e-11e5-9dec-00000aab0f01&acdnat=1433617652\_db39fcc831d2e4f24ce95f1318a00d90"" target="\_blank" rel="nofollow">http://ac.els-cdn.com/S1535610807000906/1-s2.0-S153561080700  target="\_blank" rel="nofollow">http://ac.els-cdn.com/S1535610807000906/1-s2.0-S153561080700

-X-Ray PDT

PDT has mostly shown limited ability to reach tumors. What if you could use X-Rays to reach tumors? The whole body could then be treatable.

http://cen.acs.org/articles/93/web/2015/03/Nanoparticle-Take "" target="\_blank" rel="nofollow">http://cen.acs.org/articles/93/web/2015/03/Nanoparticle-Take  target="\_blank" rel="nofollow">http://cen.acs.org/articles/93/web/2015/03/Nanoparticle-Take
Thanks for posting this.

# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 06, 2015 08:54 PM
Quote | ReplyThe minicells look extremely impressive.

We have went through the details on this thread of how one might actually mix up the minicells with bispecific antibodies. (use the find function on the wikia site).

It looks very easy. There are industrial scale suppliers of minicells out there. If you could source the minicells, bispecific antibodies and 3-BP (or almost any anti-cancer agent) you would have a very powerful, safe and non-toxic treatment.

The flu like symptoms emerged in the phase 1 trial just below the curative dose. A recent article explained how to remove this side-effect. This treatment might take another 10 years to work its way through clinical trials, though it might be possible to access it now.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 06, 2015 10:00 PM
Quote | ReplyThought it was interesting to note that 3-BP might also be of use in non-solid cancers.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081395/
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Sun Jun 07, 2015 07:34 AM
Quote | ReplyHello guys, I am a little better now. I got a lot of questions so here is some information. Dose of DCA was from 50 to 80mg/kg so I was doing the top number twice a week IV. I was also getting nutrient bags they call poly MVA and Vit C. Part of the problem was i was doing so much because i have many responsibilities and I have no family so I have to take care of myself. I was extremely dehydrated even though I drank a lot of water, got terrible headaches in the morning,blurred vision,weakness,balance issues, and mental confusion. I had been told about side effects but just tried to power through. One of the doctors posted my symptoms on the doctor site. I had not reported much to the doctors because I wanted badly to attack the cancer and I had already failed to do the keto diet. Both of my doctors had spoken to the doctor who wrote the protocol and he said a lot of people cannot tolerate the diet so just to go very low carb.I just collapsed and one day spent 2 hours trying to get out of the bathtub. I was forced to tell doctors and friends. I have now spent several days in bed after my legs swelled up and I could not walk. We have stopped DCA and I am on fluids. I will do a PET scan this week but i have a growth on my neck that does not look good, especially since it grew while I was on DCA. Jetsparkle and I are waiting for 3BP.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Jun 07, 2015 02:32 PM
Quote | ReplyGlad to hear you are feeling better. I will be interested to learn more about the swelling and other side effects.

It is very frustrating that apparently the chemical space around 3-bromopyruvate has not been explored more fully. molbase lists a range of similar compounds to 3-BP including: ethyl 3-bromopyruvate, methyl-bromopyruvate, ethyl 3-bromopyruvate, 2-propyl bromopyruvate, tert-butyl bromopyruvate, methyl ethyl bromopyruvate, 3,3-dibromo-2-oxopropanoic acid, tribromo-pyruvic acid ....

MD Anderson's  3-bromo-2-oxopropionate-1-propyl ester (aka, 3-BrOP and Glycolysin) seems to be even more effective than 3-BP (3-BrOP simply adds 3 carbons to 3-BP). 15 years after the discovery of 3-BP's anti-cancer effects an even better chemcial analog should have emerged. There are not even animal studies on any of the compounds that I listed above!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Jun 07, 2015 03:38 PM
Quote | ReplyDear All, for those who have the time, you may want to have a look at this clinic http://www.neoplas.org/id16.html

The results they claim are amaizing. And those are achieved with a releatively simple strategy. That is Lovastatin & Interferone.

They also have an interesting story behind as the doctor who is leading this clinic had an agressive form of cancer that he succeded to cure with his treatment, which now is patented.

Let me know what you think.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Jun 07, 2015 03:50 PM
Quote | ReplyI had heard of lovastatin with gamma tocotrienolin melanoma. There is a body of evidence for that combination.

http://www.ncbi.nlm.nih.gov/pubmed/17392488
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Jun 07, 2015 04:02 PM

Quote | Reply

On Jun 07, 2015 7:50 PM Jcancom wrote:

I had heard of lovastatin with gamma tocotrienolin melanoma. There is a body of evidence for that combination.

http://www.ncbi.nlm.nih.gov/pubmed/17392488 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/17392488 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/17392488
Yes, Jcancome there is a lot on statins (as anti-cancer elements) but have a look at the specific protocol of this clinic and the results that they are claiming.

Btw, to all, avoid statins while on 3BP.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Jun 07, 2015 04:24 PM
Quote | ReplyI have went through their protocol and it is interesting. I wonder how recent their results are. Melanoma treatment has been undergoing a revolution in the last few years. It seems to be the leader in pointing to the cure for cancer. It would be great to know whether these patients had been offered all available current drugs for treatment.

I would still be interested to know whether they have considered amping up their treatment with tocotrienols. Tocotrienols give you another hit on the mevalonate pathway while reducing side effects.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Jun 07, 2015 04:46 PM
Quote | ReplyYou may want to contact them and ask about tocotrienols?

Their webpage including the results is constantly updated and last was updated this month. So some of the results seem to be very recent.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Jun 07, 2015 05:00 PM
Quote | ReplyThat is true about the updates, though I am still wondering how far back their patient files stretch. The site notes that this treatment has been in development since at least 2008. There has been an ongoing revolution in melanoma treatment options over the last few years with almost constant updates.

In melanoma, it is no longer beyond imagination that currently perhaps up to a half of patients could now be able to expect complete long term responses. The expected outcomes in melanoma have rapidly improved and I am not entirely sure whether the results from their website are competitive with the latest results. Simply noting 80% response rates does not address whether the responses are long term.

I am not sure about contacting them. It always surprises me when the experts do not appear to know things that could be found with a simple pubmed search.
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# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Jun 07, 2015 05:09 PM
Quote | ReplyI dont understand why you are reffering to melanoma only. If you read further the list of cancer types and results on their webpage http://www.neoplas.org/id16.html  you will find pancreatic cancer 80%, colon and coorectal cancer 79%, etc.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Jun 07, 2015 05:12 PM
Quote | ReplyI dont understand why you are reffering to melanoma only. If you read further the list of cancer types and results on their webpage http://www.neoplas.org/id16.html  you will find pancreatic cancer 80% response, colon and coorectal cancer 79% response, etc.

I agree with the fact that we do not knwo what response is in this case, but response is better than nothing ...
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Jun 07, 2015 05:18 PM
Quote | ReplyIt was just that melanoma was the number 1 cancer type they listed on the site, though it is true that there were also colorectal and pacreatic patients that also appeared to do quite well.

Perhaps they could do even better with this approach using nanoparticles (or liposomal formulations). Would  liposomal lovastatin and/or interferon alfa-2b make any sense?

http://www.ncbi.nlm.nih.gov/pubmed/20123009

Int J Pharm. 2010 Apr 15;389(1-2):223-31. doi: 10.1016/j.ijpharm.2010.01.018. Epub 2010 Feb 1.

Preparation, characterization, and anticancer effects of simvastatin-tocotrienol lipid nanoparticles.

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Jun 07, 2015 05:40 PM
Quote | ReplyIn terms of response in melanoma the bar has really shifted. It no longer seems impossible that all metastatic melanoma patients treated with current conventional protocols or those in clinical developement might achieve a long term compete response.

These developments in clinical cancer care might be why 3-BP has lingered. If conventional medicine can come up with truly effective treatments for cancer, then people will stay within official medicine. However, if the current medicines do not offer truly long term cures, perhaps people will be more inclined to try things like 3-BP.

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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Sun Jun 07, 2015 06:35 PM

Quote | Reply

On Jun 07, 2015 9:18 PM Jcancom wrote:

It was just that melanoma was the number 1 cancer type they listed on the site, though it is true that there were also colorectal and pacreatic patients that also appeared to do quite well.

Perhaps they could do even better with this approach using nanoparticles (or liposomal formulations). Would  liposomal lovastatin and/or interferon alfa-2b make any sense?

http://www.ncbi.nlm.nih.gov/pubmed/20123009 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/20123009 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/20123009

Int J Pharm. 2010 Apr 15;389(1-2):223-31. doi: 10.1016/j.ijpharm.2010.01.018. Epub 2010 Feb 1.

Preparation, characterization, and anticancer effects of simvastatin-tocotrienol lipid nanoparticles.

Interferon alfa-2b is given as an injection into a muscle or under the skin. Lovastatin has a half-life of 2-5 hrs and a bioavailability of under 5% http://www.ncbi.nlm.nih.gov/pubmed/18563955  However if the two work then I wouldn't try and use a liposomal version of lovastatin as this could increase the side-effects
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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Sun Jun 07, 2015 06:42 PM

Quote | Reply

On Jun 07, 2015 9:40 PM Jcancom wrote:

In terms of response in melanoma the bar has really shifted. It no longer seems impossible that all metastatic melanoma patients treated with current conventional protocols or those in clinical developement might achieve a long term compete response.

These developments in clinical cancer care might be why 3-BP has lingered. If conventional medicine can come up with truly effective treatments for cancer, then people will stay within official medicine. However, if the current medicines do not offer truly long term cures, perhaps people will be more inclined to try things like 3-BP.

Yervoy an anti-ctla4 has an ORR of just 11% and CR of 2%. The anti-pd1 drugs have an ORR of 30-40% and CR of around 5%. In Yervoy refractory the ORR of anti-pd1 drugs drops to around 20% and CR to 2%. However a combo of Opdivo and Yervoy had a ORR of 60% and CR of 11%. The cost of  Opdivo is $150,000 a year and for Yervoy its $120,000 for 4 IV infusions every 3 weeks (thats the course of treatment). Every cancer patient lacks tumor-infiltrating lymphocytes to some degree. The ones that do well on these drugs have a higher amount of them, but most, well over 50% don't. Also we don't know if the CR rate is durable. Some good things are in trials http://www.nwbio.com/nw-bio-announces-data-date-dcvax-direct  http://oncosec.com/oncosec-technologies/  http://lbio.com/wp-content/uploads/2015/03/Cowen-Corp-presen
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Jun 07, 2015 08:37 PM
Quote | ReplyMetastatic melanoma really seems to be the leader in finding the cure for cancer. It is the most immumological of the cancers.

The point of note is that the Opdivo Yevoy combo is almost the worst situation for a melanoma patient. Half of the patients would have a BRAF mutation: these patients have displayed truly amazing responses. There are just so many treatments emerging for melanoma. It no longer seems speculative to suggest that a cure is emerging.

http://www.projectsinknowledge.com/Activity/pdfs/2173\_02.pdf

TVEC and other emerging oncolytic viruses, Neostem's immunotherapy, electroporation, Rose Bengal (aleady available), CART cells ... The UPENN results with chimeric antigen T cells were simply overwhelming! Clearly when this technology is rolled out for melanoma, a cure would not be unexpected.

Most of the trials start off with monotherapy. So TVEC had 11% complete responses as a monotherapy. Some of the recent numbers that used combinations are impressive. Clinical trials probably should be conducted by having a range of treatments that are applied sequentially if one treatment is found not to be effective. Given the wide range of fairly powerful options in melanoma treatment now it would be very interesting to see the sort of numbers that they could post.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Jun 07, 2015 08:53 PM
Quote | ReplyWOW! I am too controversial for the American Cancer Society discussion board (What corporations or organization is behind the ACS?). I posted to their board and mentioned the background on 3-Bromopyruvate. All my posts have just now been removed from their discussion boards and my login authorization has been blocked! I am too provocative! Am I also too much for the Cancer Compass site?

Here goes. If I am banned here too, well I just want to say to everyone it has been a great pleasure and honor to know you all.

Here is my post (Alert to censors!).

"Evidence in favor of the effectiveness of 3-BP has been accumulating over the last 14 years.

http://www.ncbi.nlm.nih.gov/pubmed/11578813
Cancer Lett. 2001 Nov 8;173(1):83-91.
Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase.

http://www.ncbi.nlm.nih.gov/pubmed/15465013
Biochem Biophys Res Commun. 2004 Nov 5;324(1):269-75.
Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP

An opinion piece in the New York Times was published April 1, 2007 that mentioned 3-BP.
http://www.nytimes.com/2007/04/01/opinion/01moss.html?\_r=0

http://www.ncbi.nlm.nih.gov/pubmed/22328020
J Bioenerg Biomembr. 2012 Feb;44(1):163-70. doi: 10.1007/s10863-012-9417-4. Epub 2012 Feb 11.
A translational study "case report" on the small molecule "energy blocker" 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside

http://www.ncbi.nlm.nih.gov/pubmed/24636230
Chin J Cancer. 2014 Jul;33(7):356-64. doi: 10.5732/cjc.013.10111. Epub 2014 Mar 14.
Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study.
The FDA granted orphan designation for 3-Bromopyruvate for pancreatic cancer (04-29-2014) and for liver and intrahepatic bile duct cancer (03-05-2013).

Prescience Labs was granted authority by the FDA to begin immediately a phase 1 trial in early 2013. This trial has not yet started.
http://presciencelabs.com/prescience-labs-investors/press.ph

Given the extraordinary published results for 3-Bromopyruvate several cancer clinics are now offering
3-BP including Dayspring (Arizona), Advanced Rejuvenation Institute (Georgia), and several in Germany (among others).

An explanation of some of the backroom issues concerning the development of 3-BP can be found in the book Tripping over the Truth. Cancer as a Metabolic Disease is another book of interest."
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Sun Jun 07, 2015 09:11 PM
Quote | ReplyI do not know what else to post so if you all want to know something ask
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sun Jun 07, 2015 10:02 PM

Quote | Reply

On Jun 08, 2015 12:53 AM Jcancom wrote:

WOW! I am too controversial for the American Cancer Society discussion board (What corporations or organization is behind the ACS?). I posted to their board and mentioned the background on 3-Bromopyruvate. All my posts have just now been removed from their discussion boards and my login authorization has been blocked! I am too provocative! Am I also too much for the Cancer Compass site?

Here goes. If I am banned here too, well I just want to say to everyone it has been a great pleasure and honor to know you all.

Here is my post (Alert to censors!).

"Evidence in favor of the effectiveness of 3-BP has been accumulating over the last 14 years.

http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813
Cancer Lett. 2001 Nov 8;173(1):83-91.
Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase.

http://www.ncbi.nlm.nih.gov/pubmed/15465013 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/15465013 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/15465013
Biochem Biophys Res Commun. 2004 Nov 5;324(1):269-75.
Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP

An opinion piece in the New York Times was published April 1, 2007 that mentioned 3-BP.
http://www.nytimes.com/2007/04/01/opinion/01moss.html?\_r=0 "" target="\_blank" rel="nofollow">http://www.nytimes.com/2007/04/01/opinion/01moss.html?\_r=0 " target="\_blank" rel="nofollow">http://www.nytimes.com/2007/04/01/opinion/01moss.html?\_r=0

http://www.ncbi.nlm.nih.gov/pubmed/22328020 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22328020 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22328020
J Bioenerg Biomembr. 2012 Feb;44(1):163-70. doi: 10.1007/s10863-012-9417-4. Epub 2012 Feb 11.
A translational study "case report" on the small molecule "energy blocker" 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside

http://www.ncbi.nlm.nih.gov/pubmed/24636230 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/24636230 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/24636230
Chin J Cancer. 2014 Jul;33(7):356-64. doi: 10.5732/cjc.013.10111. Epub 2014 Mar 14.
Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study.
The FDA granted orphan designation for 3-Bromopyruvate for pancreatic cancer (04-29-2014) and for liver and intrahepatic bile duct cancer (03-05-2013).

Prescience Labs was granted authority by the FDA to begin immediately a phase 1 trial in early 2013. This trial has not yet started.
http://presciencelabs.com/prescience-labs-investors/press.ph p"" target="\_blank" rel="nofollow">http://presciencelabs.com/prescience-labs-investors/press.ph  target="\_blank" rel="nofollow">http://presciencelabs.com/prescience-labs-investors/press.ph

Given the extraordinary published results for 3-Bromopyruvate several cancer clinics are now offering
3-BP including Dayspring (Arizona), Advanced Rejuvenation Institute (Georgia), and several in Germany (among others).

An explanation of some of the backroom issues concerning the development of 3-BP can be found in the book Tripping over the Truth. Cancer as a Metabolic Disease is another book of interest."
This to me speaks volumes. I have posted a lot of alternative/complementary stuff on that board. It has not been removed. Obviously, they are scared of something and that "something" is likely a loss of $$$ from sponsors (Pharma). I wonder what would happen if you posted on healingwell.com  ? This is disgraceful. I hope you are not removed from this board and that they are more open minded.
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# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sun Jun 07, 2015 10:14 PM

Quote | Reply

On Jun 08, 2015 2:02 AM Moonlitnight wrote:

On Jun 08, 2015 12:53 AM Jcancom wrote:

WOW! I am too controversial for the American Cancer Society discussion board (What corporations or organization is behind the ACS?). I posted to their board and mentioned the background on 3-Bromopyruvate. All my posts have just now been removed from their discussion boards and my login authorization has been blocked! I am too provocative! Am I also too much for the Cancer Compass site?

Here goes. If I am banned here too, well I just want to say to everyone it has been a great pleasure and honor to know you all.

Here is my post (Alert to censors!).

"Evidence in favor of the effectiveness of 3-BP has been accumulating over the last 14 years.

http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813  "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813  " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813  "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813  "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813  " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813  " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813  "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813  " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813  "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813  "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813  " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813  "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813  "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813  " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813  " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813  "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813  " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813  " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813  "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813  " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/11578813 "" target="\_blank" 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Cancer Lett. 2001 Nov 8;173(1):83-91.
Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase.

http://www.ncbi.nlm.nih.gov/pubmed/15465013 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/15465013 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/15465013  "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/15465013 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/15465013 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/15465013  " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/15465013 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/15465013 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/15465013  "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/15465013 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/15465013 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/15465013  "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/15465013 "" 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Biochem Biophys Res Commun. 2004 Nov 5;324(1):269-75.
Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP

An opinion piece in the New York Times was published April 1, 2007 that mentioned 3-BP.
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J Bioenerg Biomembr. 2012 Feb;44(1):163-70. doi: 10.1007/s10863-012-9417-4. Epub 2012 Feb 11.
A translational study "case report" on the small molecule "energy blocker" 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside

http://www.ncbi.nlm.nih.gov/pubmed/24636230 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/24636230 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/24636230  "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/24636230 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/24636230 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/24636230  " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/24636230 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/24636230 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/24636230  "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/24636230 "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/24636230 " target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/24636230  "" target="\_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/24636230 "" 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Chin J Cancer. 2014 Jul;33(7):356-64. doi: 10.5732/cjc.013.10111. Epub 2014 Mar 14.
Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study.
The FDA granted orphan designation for 3-Bromopyruvate for pancreatic cancer (04-29-2014) and for liver and intrahepatic bile duct cancer (03-05-2013).

Prescience Labs was granted authority by the FDA to begin immediately a phase 1 trial in early 2013. This trial has not yet started.
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Given the extraordinary published results for 3-Bromopyruvate several cancer clinics are now offering
3-BP including Dayspring (Arizona), Advanced Rejuvenation Institute (Georgia), and several in Germany (among others).

An explanation of some of the backroom issues concerning the development of 3-BP can be found in the book Tripping over the Truth. Cancer as a Metabolic Disease is another book of interest."
This to me speaks volumes. I have posted a lot of alternative/complementary stuff on that board. It has not been removed. Obviously, they are scared of something and that "something" is likely a loss of $$$ from sponsors (Pharma). I wonder what would happen if you posted on healingwell.com "" target="\_blank" rel="nofollow">http://healingwell.com " target="\_blank" rel="nofollow">healingwell.com  ? This is disgraceful. I hope you are not removed from this board and that they are more open minded.
Also, with JH and Mayo develping their own oral versions, why would your post be even faintly controversial?
Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterJcancom

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Jun 07, 2015 10:14 PM
Quote | ReplyYes, I was shocked. They might have objected to my naming of cancer clinics that were providing 3-BP treatment. I did not do that to market for these clinics. I just thought it would add some credibility that 3-BP is not quack medicine. Some might question the slow pace of uptake in 3-BP. It  appears this glacial advance has a lot more to do with trying to settle commerical and patent questions (than the well being of cancer patients).

I totally agree that when people will no longer tolerate open discussion, it surely is a bad sign that they no longer have anything relevant to say and have clearly indicated that they fear ideas that they might feel uncomfortable with (Does the American Cancer Society feel uncomfortable with the Cure for Cancer?). Teenagers generally try to push their parents buttons with vulgarity. It is interesting to observe that powerful ideas can achieve the same response.

It was especially disheartening to me because when I read through the posts some of the patients were discussing how they were carrying on with yet more chemotherapy. I would not have the heart to delete posts about 3-BP from such patients. It seems like they are taking away any chance those people might have of seeing light at the end of the tunnel.

It should be noted that there have also been irregularities on this thread. Posts have disappeared. We should keep a hard copy in order to see how the past is being rewritten.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Sun Jun 07, 2015 10:16 PM

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On Jun 08, 2015 12:37 AM Jcancom wrote:

Metastatic melanoma really seems to be the leader in finding the cure for cancer. It is the most immumological of the cancers.

The point of note is that the Opdivo Yevoy combo is almost the worst situation for a melanoma patient. Half of the patients would have a BRAF mutation: these patients have displayed truly amazing responses. There are just so many treatments emerging for melanoma. It no longer seems speculative to suggest that a cure is emerging.

http://www.projectsinknowledge.com/Activity/pdfs/2173\_02.pdf "" target="\_blank" rel="nofollow">http://www.projectsinknowledge.com/Activity/pdfs/2173\_02.pdf  target="\_blank" rel="nofollow">http://www.projectsinknowledge.com/Activity/pdfs/2173\_02.pdf

TVEC and other emerging oncolytic viruses, Neostem's immunotherapy, electroporation, Rose Bengal (aleady available), CART cells ... The UPENN results with chimeric antigen T cells were simply overwhelming! Clearly when this technology is rolled out for melanoma, a cure would not be unexpected.

Most of the trials start off with monotherapy. So TVEC had 11% complete responses as a monotherapy. Some of the recent numbers that used combinations are impressive. Clinical trials probably should be conducted by having a range of treatments that are applied sequentially if one treatment is found not to be effective. Given the wide range of fairly powerful options in melanoma treatment now it would be very interesting to see the sort of numbers that they could post.
Who has got $270,000 for both these drugs. The NHS will never pay this amount. Also the rate of serious drug-related side effects was highest in the combination arm at 55%, forcing 36% of patients in that group to halt therapy. CAR-T seems hype, even if it does work then it only goes after one antigen and not the full set, and only in non solid cancers. Also some of the prices I've heard are $500-750,000. In the Phase III for TVEC is was against GM-CSF, when did GM-CSF become SOC for melanoma?. TVEC is only useful for patients when there is an injectable lesion also. Only one-third of advanced melanoma patients have some skin, soft tissue or nodal disease that is amenable to TVEC injection. OS will not be attained by only killing lesions on the skin, as the metastatic disease in the liver, brain and lungs are ultimately fatal. 11% of 436 is almost 48, so just 48% have a CR and only 26 had a ORRQuote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitter james-peters
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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Sun Jun 07, 2015 10:22 PM

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On Jun 08, 2015 2:14 AM Jcancom wrote:

Yes, I was shocked. They might have objected to my naming of cancer clinics that were providing 3-BP treatment. I did not do that to market for these clinics. I just thought it would add some credibility that 3-BP is not quack medicine. Some might question the slow pace of uptake in 3-BP. It  appears this glacial advance has a lot more to do with trying to settle commerical and patent questions (than the well being of cancer patients).

I totally agree that when people will no longer tolerate open discussion, it surely is a bad sign that they no longer have anything relevant to say and have clearly indicated that they fear ideas that they might feel uncomfortable with (Does the American Cancer Society feel uncomfortable with the Cure for Cancer?). Teenagers generally try to push their parents buttons with vulgarity. It is interesting to observe that powerful ideas can achieve the same response.

It was especially disheartening to me because when I read through the posts some of the patients were discussing how they were carrying on with yet more chemotherapy. I would not have the heart to delete posts about 3-BP from such patients. It seems like they are taking away any chance those people might have of seeing light at the end of the tunnel.

It should be noted that there have also been irregularities on this thread. Posts have disappeared. We should keep a hard copy in order to see how the past is being rewritten.
The ASC added Coleys Toxins to their quack cancer cures list for years and years. If it was for Dr Lloyd J. Old MD, Helen Coley Nauts and many others it would still be there now http://www.cancerresearch.org/about/history
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Jun 07, 2015 10:23 PM
Quote | ReplyThe problem with metastatic melanoma was the standard of care at the time of the TVEC trial (dacarbazine) was so toxic and non-effective that even the FDA did not believe in SOC.

I do not understand why TIL therapy was in development for decades and there had never been advanced clinical trials. It seems like a fairly successful treatment, though it is still unclear after all that time. They should have brought something to trial years ago and improve it from there.

The results from the CAR were stunning. The clinical trial results keep coming in great. Melanoma would be the obvious solid tumor to turn to after leukemia and lymphomas.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sun Jun 07, 2015 10:27 PM

Quote | Reply

On Jun 08, 2015 2:22 AM james-peters wrote:

On Jun 08, 2015 2:14 AM Jcancom wrote:

Yes, I was shocked. They might have objected to my naming of cancer clinics that were providing 3-BP treatment. I did not do that to market for these clinics. I just thought it would add some credibility that 3-BP is not quack medicine. Some might question the slow pace of uptake in 3-BP. It  appears this glacial advance has a lot more to do with trying to settle commerical and patent questions (than the well being of cancer patients).

I totally agree that when people will no longer tolerate open discussion, it surely is a bad sign that they no longer have anything relevant to say and have clearly indicated that they fear ideas that they might feel uncomfortable with (Does the American Cancer Society feel uncomfortable with the Cure for Cancer?). Teenagers generally try to push their parents buttons with vulgarity. It is interesting to observe that powerful ideas can achieve the same response.

It was especially disheartening to me because when I read through the posts some of the patients were discussing how they were carrying on with yet more chemotherapy. I would not have the heart to delete posts about 3-BP from such patients. It seems like they are taking away any chance those people might have of seeing light at the end of the tunnel.

It should be noted that there have also been irregularities on this thread. Posts have disappeared. We should keep a hard copy in order to see how the past is being rewritten.
The ASC added Coleys Toxins to their quack cancer cures list for years and years. If it was for Dr Lloyd J. Old MD, Helen Coley Nauts and many others it would still be there now http://www.cancerresearch.org/about/history "" target="\_blank" rel="nofollow">http://www.cancerresearch.org/about/history " target="\_blank" rel="nofollow">http://www.cancerresearch.org/about/history
That is just ridiculous. I'd like to get my hands on Coley's toxins. I keep hearing that hyperthermia has taken over but the cost is astronomical.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Jun 07, 2015 10:57 PM
Quote | ReplyI have looked around the internet for claims that 3-BP is quack medicine: no takers. I wonder if the ACS considers 3-BP quack medicine or more ominously it is on their "Do not comment" list.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sun Jun 07, 2015 11:16 PM

Quote | Reply

On Jun 08, 2015 2:57 AM Jcancom wrote:

I have looked around the internet for claims that 3-BP is quack medicine: no takers. I wonder if the ACS considers 3-BP quack medicine or more ominously it is on their "Do not comment" list.
Was adding the links a violation of their TOS?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Jun 07, 2015 11:20 PM
Quote | ReplyI do not think so, as I had done that before without problem.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Jun 07, 2015 11:44 PM
Quote | ReplyI have just read the ACS User Agreement in its entirety. I found it very edifying, I suggest others do likewise, you will feel elevated by doing so.

The grounds for deleting posts are below. I really do not see how offensive, racist, lewd, profance, obscene, pornographic, hateful ..... would apply. Perhaps they should have added the word provocative.

"...to delete any information or data which ACS becomes aware of which ACS determines, in its sole and absolute discretion, to be offensive, racist, lewd, profane, obscene, pornographic, hateful, rude, abusive, disruptive, defamatory or otherwise in violation of this Usage Agreement."

# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Mon Jun 08, 2015 12:02 AM
Quote | ReplyIt just occurred to me that probably the best way to get around the 3-BP logjam is for the Hopkins people to win a Nobel prize. When the vested interested no longer are willing to talk about ideas and would much rather ignore them, it is probably a good time to bring things out to the limelight.

The Hopkins researchers are a great example of dissenting opinion. Awarding them a Nobel would make a whole bunch of people very uncomfortable. Foremost among them would be those who thought one of these researchers required a psychiatric assessment for curing cancer.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Mon Jun 08, 2015 12:46 PM
Quote | ReplyI just wanted to correct my comment on the Inspire thread patient. I posted that this patient had 70 mets. However, these 70 brain mets were only present some time after the 3-BP treatment. At the time of 3-BP treatment.

"we went for 3BP. She had multiple brain mets and the cancer was back in her lung, bones, and liver. We felt something like 3BP was our only shot."

http://www.inspire.com/groups/ovarian-cancer-national-allian
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Mon Jun 08, 2015 12:52 PM

Quote | Reply

On Jun 08, 2015 4:46 PM Jcancom wrote:

I just wanted to correct my comment on the Inspire thread patient. I posted that this patient had 70 mets. However, these 70 brain mets were only present some time after the 3-BP treatment. At the time of 3-BP treatment.

"we went for 3BP. She had multiple brain mets and the cancer was back in her lung, bones, and liver. We felt something like 3BP was our only shot."

http://www.inspire.com/groups/ovarian-cancer-national-allian ce/discussion/1st-stateside-3-bromopyruvate/?reply\_sort=asc&page=7#replies"" target="\_blank" rel="nofollow">http://www.inspire.com/groups/ovarian-cancer-national-allian  target="\_blank" rel="nofollow">http://www.inspire.com/groups/ovarian-cancer-national-allian
What makes this blocking doubly strange is that there is a very robust thread on soursop/graviola with various recipes for it, where to get the leaves, etc.  I would imagine the ACS would find that more of a health concern. Graviola is what we are using, along with taxanes and noscapine, to address mitosis/tubulin.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Mon Jun 08, 2015 01:00 PM
Quote | ReplyIn the modern context, it would seem the best way to avoid "The Whole World is Watching" scenario is to just give everyone some bandwidth and push it off to the corner. That would not be difficult to do.

The ACS site does have a few comments on 3-Bromopyruvate (one of my comments from several months back was among them until recently). It appears that they might have a problem with 3-BP now that it is entering acceptance in clinics in America and around the world.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Meech90 on Mon Jun 08, 2015 01:22 PM

Quote | Reply

On Jun 08, 2015 4:46 PM Jcancom wrote:

I just wanted to correct my comment on the Inspire thread patient. I posted that this patient had 70 mets. However, these 70 brain mets were only present some time after the 3-BP treatment. At the time of 3-BP treatment.

"we went for 3BP. She had multiple brain mets and the cancer was back in her lung, bones, and liver. We felt something like 3BP was our only shot."

http://www.inspire.com/groups/ovarian-cancer-national-allian ce/discussion/1st-stateside-3-bromopyruvate/?reply\_sort=asc&page=7#replies"" target="\_blank" rel="nofollow">http://www.inspire.com/groups/ovarian-cancer-national-allian  target="\_blank" rel="nofollow">http://www.inspire.com/groups/ovarian-cancer-national-allian
So 3-BP wasn't effective in her case? What happened to the mets outside the brain?Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterkcervantes

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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Mon Jun 08, 2015 01:54 PM
Quote | ReplyHas anyone on this thread tried Methylglyoxal?  I've received it from a reliable source but am wondering if there needs to be some sort of preparation prior to administration?  The case study from India indicated the preparation was simple with 8ml of Methylglyoxal mixed with 60 ml of water.  Just wanting to make sure Im doing it correctly.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Mon Jun 08, 2015 01:57 PM
Quote | ReplyIt would be important to carefully read the protocol used in the Indian clinical trial. I think they noted it was important to add in vitamin C for MG to be effective.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Mon Jun 08, 2015 02:03 PM
Quote | ReplyFor the patient treated with 3-BP noted above with "mulitple brain mets" a fuller patient history is given on the Inspire thread. Three doses of 3-BP might not have had much of an impact long term. No mention of dosing is given.

With the melanoma patient straight 3-BP given IV only had temporary effects when first given, as evidenced by the LDH numbers. The tumors at first seemed to be stunned, though not totally destroyed by 3-BP treatment. With the liver cancer patient it is only after the third high dose treatment does a massive anti-cancer effect become apparent.

The Inspire thread patient in many ways does not seem to be an ideal patient for 3-BP. Others on this thread have noted earlier that the port surgery might have contributed to the side effects noted.

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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Mon Jun 08, 2015 02:04 PM
Quote | ReplyI have added vitamin C and B complex.  Thank you Jcancom!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Mon Jun 08, 2015 05:05 PM
Quote | ReplyPNAS2014-04-01Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans.

Weijing Cai, Jaime Uribarri, Li Zhu, Xue Chen, Shobha Swamy, Zhengshan Zhao, Fabrizio Grosjean, Calogera Simonaro, George A Kuchel, Michal Schnaider-Beeri, Mark Woodward, Gary E Striker, Helen Vlassara

PMID 24567379AbstractAge-associated dementia and Alzheimer's disease (AD) are currently epidemic. Neither their cause nor connection to the metabolic syndrome (MS) is clear. Suppression of deacetylase survival factor sirtuin 1 (SIRT1), a key host defense, is a central feature of AD. Age-related MS and diabetes are also causally associated with suppressed SIRT1 partly due to oxidant glycotoxins [advanced glycation end products (AGEs)]. Changes in the modern diet include excessive nutrient-bound AGEs, such as neurotoxic methyl-glyoxal derivatives (MG). To determine whether dietary AGEs promote AD, we evaluated WT mice pair-fed three diets throughout life: low-AGE (MG(-)), MG-supplemented low-AGE (MG(+)), and regular (Reg) chow. Older MG(+)-fed mice, similar to old Reg controls, developed MS, increased brain amyloid-β42, deposits of AGEs, gliosis, and cognitive deficits, accompanied by suppressed SIRT1, nicotinamide phosphoribosyltransferase, AGE receptor 1, and PPARγ. These changes were not due to aging or caloric intake, as neither these changes nor the MS were present in age-matched, pair-fed MG(-) mice. The mouse data were enhanced by significant temporal correlations between high circulating AGEs and impaired cognition, as well as insulin sensitivity in older humans, in whom dietary and serum MG levels strongly and inversely associated with SIRT1 gene expression. The data identify a specific AGE (MG) as a modifiable risk factor for AD and MS, possibly acting via suppressed SIRT1 and other host defenses, to promote chronic oxidant stress and inflammation. Because SIRT1 deficiency in humans is both preventable and reversible by AGE reduction, a therapeutic strategy that includes AGE reduction may offer a new strategy to combat the epidemics of AD and MS.Quote | Reply

# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Mon Jun 08, 2015 05:11 PM

Quote | Reply

On Jun 08, 2015 9:05 PM Jcancom wrote:

PNAS2014-04-01Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans.

Weijing Cai, Jaime Uribarri, Li Zhu, Xue Chen, Shobha Swamy, Zhengshan Zhao, Fabrizio Grosjean, Calogera Simonaro, George A Kuchel, Michal Schnaider-Beeri, Mark Woodward, Gary E Striker, Helen Vlassara

PMID 24567379AbstractAge-associated dementia and Alzheimer's disease (AD) are currently epidemic. Neither their cause nor connection to the metabolic syndrome (MS) is clear. Suppression of deacetylase survival factor sirtuin 1 (SIRT1), a key host defense, is a central feature of AD. Age-related MS and diabetes are also causally associated with suppressed SIRT1 partly due to oxidant glycotoxins [advanced glycation end products (AGEs)]. Changes in the modern diet include excessive nutrient-bound AGEs, such as neurotoxic methyl-glyoxal derivatives (MG). To determine whether dietary AGEs promote AD, we evaluated WT mice pair-fed three diets throughout life: low-AGE (MG(-)), MG-supplemented low-AGE (MG(+)), and regular (Reg) chow. Older MG(+)-fed mice, similar to old Reg controls, developed MS, increased brain amyloid-β42, deposits of AGEs, gliosis, and cognitive deficits, accompanied by suppressed SIRT1, nicotinamide phosphoribosyltransferase, AGE receptor 1, and PPARγ. These changes were not due to aging or caloric intake, as neither these changes nor the MS were present in age-matched, pair-fed MG(-) mice. The mouse data were enhanced by significant temporal correlations between high circulating AGEs and impaired cognition, as well as insulin sensitivity in older humans, in whom dietary and serum MG levels strongly and inversely associated with SIRT1 gene expression. The data identify a specific AGE (MG) as a modifiable risk factor for AD and MS, possibly acting via suppressed SIRT1 and other host defenses, to promote chronic oxidant stress and inflammation. Because SIRT1 deficiency in humans is both preventable and reversible by AGE reduction, a therapeutic strategy that includes AGE reduction may offer a new strategy to combat the epidemics of AD and MS.I've written a lot on AGEs and read a lot of Aubrey de Grey's work. Keep off the toast and barbecued meats. (I make my toast in a very low oven so that is just dries out.)
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Mon Jun 08, 2015 06:02 PM
Quote | ReplyAny update today on the Alabama clinic or the Toronto clinic with regards to 3-BP treatment?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Mon Jun 08, 2015 06:44 PM
Quote | ReplyI wonder whether with melanoma we have already reached the point where with existing treatments the typical patient at first presentation will achieve a reasonably good outcome. It would seem possible that such a typical patient might at worst be stage 3. Current treatments can provide good responses in these patients. The problem up to this point has been that no effective treatments could help prevent the inevitable slide into more severe stages of illness. Currently, melanoma patients might start receiving effective non-toxic treatment during their first medical appointment after diagnosis.

Even for those patients who are watching and waiting their melanoma (after surgery etc.) a round or two of IV 3-BP per year (possibly with paracetamol) would seem to be a good preventative strategy.

If it were true that typical patients can now usually be effectively managed, it could have ominous implications for future drug development. If the number of melanoma patients who would now likely progress to metastatic illness is quite small the market opportunity for drug developers might not be considered sufficient.

We should know the answer to this suggestion fairly soon, as these statistics should be emerging fairly soon.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by mahkcots on Mon Jun 08, 2015 09:57 PM
Quote | ReplyCould you provide me the names of the.clinic s in Germany that are offering 3bp. Also, are you aware whether or not these or any others.offer  it through TACE? If necessary this can be a private response.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Mon Jun 08, 2015 11:19 PM

Quote | Reply

On Jun 08, 2015 10:02 PM Jcancom wrote:

Any update today on the Alabama clinic or the Toronto clinic with regards to 3-BP treatment?
My g/f emailed Dr. G at the Tto clinic and is waiting to hear back from him.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Tue Jun 09, 2015 05:17 AM

Quote | Reply

On Jun 09, 2015 1:57 AM mahkcots wrote:

Could you provide me the names of the.clinic "" target="\_blank" rel="nofollow">http://the.clinic " target="\_blank" rel="nofollow">the.clinic  s in Germany that are offering 3bp. Also, are you aware whether or not these or any others.offer "" target="\_blank" rel="nofollow">http://others.offer " target="\_blank" rel="nofollow">others.offer  it through TACE? If necessary this can be a private response.
I sent a few names to you. Regarding, TACE you could check with Prof. Vogl.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Tue Jun 09, 2015 01:51 PM

Quote | Reply

On Jun 09, 2015 9:17 AM Danielus wrote:

On Jun 09, 2015 1:57 AM mahkcots wrote:

Could you provide me the names of the.clinic " target="\_blank" rel="nofollow">the.clinic  " target="\_blank" rel="nofollow">the.clinic " target="\_blank" rel="nofollow">the.clinic  "" target="\_blank" rel="nofollow">http://the.clinic " target="\_blank" rel="nofollow">the.clinic  " target="\_blank" rel="nofollow">the.clinic " target="\_blank" rel="nofollow">the.clinic  " " target="\_blank" rel="nofollow">the.clinic " target="\_blank" rel="nofollow">the.clinic  " target="\_blank" rel="nofollow">the.clinic " target="\_blank" rel="nofollow">the.clinic  "" target="\_blank" rel="nofollow">http://the.clinic " target="\_blank" rel="nofollow">the.clinic  " target="\_blank" rel="nofollow">the.clinic " target="\_blank" rel="nofollow">the.clinic  " " target="\_blank" rel="nofollow">the.clinic " target="\_blank" rel="nofollow">the.clinic  " target="\_blank" rel="nofollow">the.clinic " target="\_blank" rel="nofollow">the.clinic  "" target="\_blank" rel="nofollow">http://the.clinic " 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rel="nofollow">the.clinic  " target="\_blank" rel="nofollow">the.clinic " target="\_blank" rel="nofollow">the.clinic  s in Germany that are offering 3bp. Also, are you aware whether or not these or any others.offer " target="\_blank" rel="nofollow">others.offer  " target="\_blank" rel="nofollow">others.offer " target="\_blank" rel="nofollow">others.offer  "" target="\_blank" rel="nofollow">http://others.offer " target="\_blank" rel="nofollow">others.offer  " target="\_blank" rel="nofollow">others.offer " target="\_blank" rel="nofollow">others.offer  " " target="\_blank" rel="nofollow">others.offer " target="\_blank" rel="nofollow">others.offer  " target="\_blank" rel="nofollow">others.offer " target="\_blank" rel="nofollow">others.offer  "" target="\_blank" rel="nofollow">http://others.offer " target="\_blank" rel="nofollow">others.offer  " target="\_blank" rel="nofollow">others.offer " target="\_blank" rel="nofollow">others.offer  " " target="\_blank" rel="nofollow">others.offer " target="\_blank" rel="nofollow">others.offer  " target="\_blank" rel="nofollow">others.offer " target="\_blank" rel="nofollow">others.offer  "" 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target="\_blank" rel="nofollow">others.offer  " target="\_blank" rel="nofollow">others.offer " target="\_blank" rel="nofollow">others.offer  "" target="\_blank" rel="nofollow">http://others.offer " target="\_blank" rel="nofollow">others.offer  " target="\_blank" rel="nofollow">others.offer " target="\_blank" rel="nofollow">others.offer  " " target="\_blank" rel="nofollow">others.offer " target="\_blank" rel="nofollow">others.offer  " target="\_blank" rel="nofollow">others.offer " target="\_blank" rel="nofollow">others.offer  "" target="\_blank" rel="nofollow">http://others.offer " target="\_blank" rel="nofollow">others.offer  " target="\_blank" rel="nofollow">others.offer " target="\_blank" rel="nofollow">others.offer  " " target="\_blank" rel="nofollow">others.offer " target="\_blank" rel="nofollow">others.offer  " target="\_blank" rel="nofollow">others.offer " target="\_blank" rel="nofollow">others.offer  "" target="\_blank" rel="nofollow">http://others.offer " target="\_blank" rel="nofollow">others.offer  " target="\_blank" rel="nofollow">others.offer " target="\_blank" rel="nofollow">others.offer  " target="\_blank" rel="nofollow">others.offer " target="\_blank" rel="nofollow">others.offer  " target="\_blank" rel="nofollow">others.offer " target="\_blank" rel="nofollow">others.offer  it through TACE? If necessary this can be a private response.
I sent a few names to you. Regarding, TACE you could check with Prof. Vogl.
I am not understanding how to post a new question or comment that isn't a reply to a previous comment.

Question: I have heard that people received "one IV" of 3 BP. So I am wondering how the Toronto MD is giving "2 or 3 a week for 12 weeks." Maybe this is to prevent the possibility of TLS and to permit better monitoring. Three months in Toronto is horrendously expensive, along with his fee (and for us, boarding two dogs at $66 a day). I am waiting for him to call me back re patient experiences.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Tue Jun 09, 2015 01:56 PM
Quote | ReplyIt is confusing about the reply or quote options. Just click reply and you can comment without having to quote.

The melanoma patient received several treatments per week. Receiving 2 or 3 IV 3-BP treatments with monitoring should not be a problem.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Tue Jun 09, 2015 02:00 PM

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On Jun 09, 2015 5:56 PM Jcancom wrote:

It is confusing about the reply or quote options. Just click reply and you can comment without having to quote.

The melanoma patient received several treatments per week. Receiving 2 or 3 IV 3-BP treatments with monitoring should not be a problem.
That's what I did (I thought...) I still find it challenging to wrap my mind around the fact there are so few patients who seem to have a) undergone, and b) benefitted from 3-BP treatment. I wonder if there are any who haven't benefitted. I asked the good doc to provide patient names/stories if he can.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Tue Jun 09, 2015 02:00 PM
Quote | ReplyOne IV of 3BP is not enough. Depending on the dose, etc. more are required. Usually, the first IV seems to take part or all pain away when that is present.
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