Game Progression

In order to make progression, it is necessary to unlock various characters and chapters.

On this page, the unlock requirements for these steps in progression are listed in order of rough availability.

# Major Chapter Unlocks

## Womb

An entrance to Womb is unlocked by beating Mom 1 time.  The Womb

This entrance will spawn after beating Mom on every subsequent run.

* It is possible to reach Womb alternatively via a trapdoor generated by  or .

## Sheol and Cathedral

Entrances to Sheol and Cathedral are unlocked by beating Mom's Heart 11 times.  It Lives!

These entrances will spawn after beating It Lives, which replaces Mom's Heart on every subsequent run.

 The entrances will also spawn after beating Hush.

* It is possible to reach Sheol alternatively via a trapdoor generated by  or  on Womb II, or through a trapdoor which spawns in the Devil Room on Womb II.
* It is possible to reach Cathedral alternatively via a beam of light which spawns in the Angel Room on Womb II.

## Dark Room and Chest

The player will transport to Dark Room when entering the chest spawned by Satan so long as the player holds .

The player will transport to Chest when entering the chest spawned by Isaac so long as the player holds .

 is unlocked by beating Satan 5 times.  The Negative

 is unlocked by beating Isaac 5 times.  The Polaroid

Once unlocked  and/or  will always spawn after beating Mom(but only one can be taken).

* It is possible to enter Dark Room alternatively by using the Sacrifice Room 12+ Times on any floor.

## Mega Satan

A door to Mega Satan will appear at the beginning of Dark Room and Chest once ??? or The Lamb has been beaten once.  Angels

This door can be opened by collecting  and , by using , , or , using  or  on the door, or taking damage while having .

It is possible to obtain  and  by bombing the angel statues inside of Angel Rooms and defeating the angel spawned.
Alternatively these angels will spawn when using the Sacrifice Room.

* Note: It is possible to obtain both  and  before unlocking  Angels; however the door to Mega Satan will not appear until the achievement is unlocked.

## ???

A door to ??? is unlocked by beating Mom's Heart 10 times.  Blue Womb

This door will spawn after beating It Lives in under 30 minutes on any subsequent run.

## The Void

A door to The Void is unlocked by beating Hush 1 time.

This door will spawn after beating Hush on any subsequent run.

A portal to The Void will also have a chance to spawn after most major bosses on any subsequent run.

## Alternate Floors

Doors to Downpour, Mines, Mausoleum and Corpse will unlock by beating Hush 3 times.  A Secret Exit

These doors will spawn in the Boss Room once the boss is defeated on chapters I, II, and III on subsequent runs.

* See  and  on how to access Corpse.

## Ascent and Home

A door to a special version of Mausoleum will appear at the beginning of Depths II on every subsequent run once Mother has been beaten 1 time.  A Strange Door

This door can be opened by interacting with it, by using either  or .

It can also be opened with  and .

This can be done using any form of teleporting (e.g. ) after beating Mom. (a marked skull (see Rocks) on the floor will always contain a ) card

* Although difficult to achieve under normal circumstances, if Isaac uses  in the starting room *without entering any other rooms*, he will instantly warp to Home, skipping the Ascent. This works regardless of if  Mother has been defeated or not, meaning that it's theoretically possible to reach Home without even killing Mom once.
	+ This can be done through various means.  Eden can start with , and use it as soon as the first room. If Isaac has , , and , using  and then  in succession will warp Isaac to Home.