Page 421-430

Wow, our thread has been drifting along and we
have been missing out on quite a bit that has been happening in the 3-BP
 universe.

For example, I had been very unaware of the severity of burden on
global health related to the fungal infection, C. neoformans. This
infection causes substantial mortaility and morbidity among those with
HIV and cancer. Existing treatments are not highly effective, nor
inexpensive. 3-BP appears to have a considerable potential to help treat
 this condition and perhaps others as expressed in the recent 3-BP
review.

https://www.ncbi.nlm.nih.gov/pubmed/?term=27983708

https://www.ncbi.nlm.nih.gov/pubmed/?term=23541578

This newly revealed potential role for 3-BP might be of considerable
importance in assisting 3-BP through the clinic for cancer. Obviously a
large dataset of patients treated safely and effectively with it for
other rationales could be extremely helpful. It also might explain
something that has puzzled me for quite a while. Why are some Chinese
online chemical houses offering kilogram scale quantities of
pharmaceutical grade 3-BP? I could not understand that. Perhaps the
above is a plausible explanation.

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What do you guys think of this recent article saying
 that a high fat diet aids in the spread of cancer due to CD36, which is
 a protein identified to be important to metastasis and mediated by
fatty acids: https://www.sciencedaily.com/releases/2016/12/161207132117.h Seems to go against the conventional wisdom of the metabolic theory of cancer.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by dumbcritic on Mon Jan 02, 2017 12:33 PM
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Dr. Ko will give a presentation entitled: 'Understanding and Targeting Cancer Cell Energy Metabolism' at this http://metabolictherapeuticsconference.com/speakers/

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Sat Jan 21, 2017 07:12 PM
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I want the thread to know that a poster and
friend of our thread, falcon, has lost his mother to cancer. He tried
his best to find the treatments that would be of help, though the cancer
 was stronger. It sobering to remember that several others who have
posted to our thread have likewise succumbed to their illness.

I so greatly wish that 2017 will bring more happiness and less sorrow in cancer therapy.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Sat Jan 21, 2017 07:14 PM
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Along that line of thought there is this:

https://www.nytimes.com/2016/12/07/health/cancer-immunothera

If the TIL approach that has been championed by the NCI for decades
could finally globailze from melanoma to a wider range of cancers, then
this would be a sparkle of light to celebrate.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Sat Jan 21, 2017 07:44 PM
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Pluripotency runs through the metabolic system? Question is: could you selectively differentiate cancer cells?

https://www.ncbi.nlm.nih.gov/pubmed/25738455?dopt=Abstract&a

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Sat Jan 21, 2017 11:04 PM
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I also noticed that another patent application
has been filed for Mito-3-BP. This one clearly has large potential. If
we can sidestep all those issues of cell entry through MCT and just drag
 it in an ionic tug boat, then the game certainly changes. The original
article of a few years back was impressive.

I would still like to see the in vivo work. I want to be clear that
toxicity is not an issue. I am not entirely sure how specific Mito-3-BP
would be for cancerous cells. It would be great if this could be
clarified.

Is it typical that multiple patents will be filed, when the research
into a product seems dormant? There have been quite a few Mito-3-BP
patents filed to date and additional publication of research has not
been forthcoming.

http://www.freshpatents.com/-dt20170119ptan20170014361.php

Wonder why https://www.ncbi.nlm.nih.gov/pubmed/27983708 went with 3-BrOP over Mito-3-BP? (perhaps Mito-3-BrOP?)

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Tue Jan 24, 2017 06:43 PM
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This is starting to get quite exciting!

We have talked for a long time about minicells.

There are three ingredients needed: a therapeutic payload, minicells
and a targetting mechanism. Only the last item posed particular trouble
sourcing.

The bispecific antibodies needed were not readily available, some
were from animal sources which could cause an immune response etc.. The
below article apparently has found a way around these obstacles by using
 folic acid and off-the-shelve ingredients. They showed as a proof of
principle that using the payload of shRNA VEGF they could achieve a
response in mice.

The article noted that the presence of folic acid reduces the
effectiveness of the folic acid coated minicells. This makes me wonder
whether reducing folic acid levels (with anti-folates?) might increase
the anti-cancer effect noted in the article.

Figure 8 from the article was somewhat misleading. The figure shows
the tumor, liver cells and heart cells lit up due to the high presence
of the minicells. This might indicate concerns about possible side
effects to the heart and the liver. However, the authors explain that
the minicells were only present in these organs due to blood flow: it
was expected that little if any of the minicells would actually be
retained in the tissues, most of the minicells were retained in the
tumor. Are there not tests that look for chemicals that are incorporated
 into cells and not merely bystanders?

The research into minicells continues and they increasingly appear to
 offer an attractive therapeutic platform. I can hardly wait to see what
 results will be obtained when oncoviruses, mito-3BP, shRNA LDH, ... are
 tried. A wisely chosen combination should have simply near total power
to control cancer.

Engeneic, the company developing these minicells, notes on their
website, that they are researching chemotherapies that are 1000 more
potent than those currently used. Such chemo could never be used
systemically, though in minicells dosed at 1 million times lower doses,
there would likely be no side effects.

(Not sure of the broader relevance of the PSMA [prostate specific
membrane antigen] uptake noted in the article for prostate
cancer.)

https://www.ncbi.nlm.nih.gov/pubmed/27378204

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Tue Jan 24, 2017 07:22 PM
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Hmm, this goes back to ernemef's article on the radioactive PMSA treatment.

http://atlasofscience.org/a-novel-radionuclide-treatment/

No, side effects were noted in normal prostate cells.

Would have liked to see in the folate minicell article if there might
 have been any prostate problems. Normal prostate cells express PMSA,
prostate cancer cells express quite a bit more. Wonder if this might
limit the application of folate minicells cells as a cancer
treatment.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Wed Jan 25, 2017 12:07 AM
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Very interesting!

Here's a preprint of an article that focuses in on the GSH 3-BP
connection. The point noted earlier on the thread that 3-BP has a nearly
 singularly unique property among chemotherapeutics in that it can be
recalled by applying GSH/NAC is highlighted in the article. This feature
 if it had been fully appreciated at Bracht might have changed what
happened there. GSH/NAC should become a standard on the shelf emergency
protocol for 3-BP treatment crises.

The article below is also of interest in that it goes on to mention
high dose paracetamol with NAC rescue. I thought that there was an error
 when the article talked of >10g/m2 that seemed much too much
paracetamol (perhaps even toxically so).

However, https://www.ncbi.nlm.nih.gov/pubmed/12690304
 was a phase 1 trial using an MTD of 15g/m2. It is surprising to me
that this has not been noted before. A combination of 3-BP along with
high dose paracetamol with NAC rescue might yield more responses, though
 this would need to be done carefully preferably within a highly
professional medical context.

This study found a counterintuitive decrease in effectiveness with high dose paracetamol treatment.  https://www.ncbi.nlm.nih.gov/pubmed/17526808  &nbs

Would really like to see a minicell treatment using paracetamol or
shGSH. In my view it is becoming increasingly clear that using systemic
dosing when minicells are available is primitive.

http://ac.els-cdn.com/S0306987716303462/1-s2.0-S030698771630

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Wed Jan 25, 2017 12:23 AM
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Brings me back to this one.

Wonder why the preprint didn't mention Curcumin?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567432/

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Wed Jan 25, 2017 10:42 PM
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Dayspring is once again an official named 3-Bromopyruvate clinic.

http://www.dayspringcancerclinic.com/

I think in light of what happened at Bracht the thread should
consider a treatment protocol that could address some of the safety
issues that are inherent to the use of 3-BP.

Some of the ideas I have thought of include:

- on-site GSH if treatment were to go wrong (though not necessarily requiring that the clinic itself would administer it)

- spectrophotometer to confirm dosing for each batch

- only single patient dosing if a new batch or formulation is used with a 1 hour window to the next dosing

- no single employee clinics. If something were to go wrong, then a team would be needed to help

- more transparency with actual clinical results would also be very welcome

The big concern is that even after a serious incident often there are no changes that would truly improve safety.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Wed Jan 25, 2017 10:59 PM
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I am sure that D was all over this one, though I
only noticed now that metformin combined with 2DG seems to be fairly
effective. The idea was that 2DG for blocking glycolysis and metformin
for OXPHOS. An article noted that using only 2DG or 3-BP might be
ineffective because only one energy pathway would be blocked.

https://www.ncbi.nlm.nih.gov/pubmed/21992792

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by dumbcritic on Mon Jan 30, 2017 06:26 PM
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“We will start with a baseline trial testing the
arginine-depleting drug against sarcomas with this defect, and then we
can begin layering additional drugs on top of that therapy,” Van Tine
said. “Unlike breast cancer, for example, sarcomas currently have no
targeted therapies. If this strategy is effective, it could transform
the treatment of 90 percent of sarcoma tumors.”

https://medicine.wustl.edu/news/study-unveils-new-way-starve

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by dumbcritic on Mon Jan 30, 2017 11:51 PM
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Look to improve in-situ tumor vaccination

In preclinical studies although cryoablated mice remain tumor free,
only 20-50% survive a rechallenge with melanoma cells, indicating that a
 minority developed efficient immunologic memory against the tumor.
These findings emphasized the need to boost antitumor immunity by
combining tumor-destructive treatment with adjuvant immunotherapy. In
further studies with the administration of the toll-like receptor (TLR) 9
 agonist, CpG oligodeoxynucleotides, immediately after the ablation
elevates the numbers of cytotoxic t lymphocytes in the lymph nodes and
promoted survival rates upon rechallenge to 90-100% http://cancerres.aacrjournals.org/content/66/14/7285.long http://journals.plos.org/plosone/article?id=10.1371/journal. http://cancerres.aacrjournals.org/content/68/13/5390.long

Individual TLR agonists can significantly improve the host's immune
response to small tumors. But to be effective against large established
tumors, a number of TLR agonist combinations seem to be needed. Based on
 preliminary studies, the combination of TLRs 7/8 with a TLR 9 can
eliminate most large established tumors https://jitc.biomedcentral.com/articles/10.1186/2051-1426-2-
 To further improve upon these effects then you could also add a STING
agonist as well
http://www.cell.com/cell-reports/fulltext/S2211-1247(15)00432-5 Some
previous studies shows that TLR 9 and STING synergistic effect http://onlinelibrary.wiley.com/doi/10.1002/eji.201445132/ful

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by dumbcritic on Tue Jan 31, 2017 12:09 AM
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'' Seems
 to go against the conventional wisdom of the metabolic theory of
cancer.'' It's the chicken or the egg argument. Whether it's the
metabolic abnormalities that cause the mutations observed in cancer
cells or whether it's the mutations that produce the metabolic
abnormalities. It's possible as certain cancer cells evolve they
can utilize certain lipids. So this might call into question the
ketogenic diet for patients.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by chris1023 on Fri Feb 03, 2017 01:04 PM
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I also think they should post clinical findings in all cases. Not just the ones that respond.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by dumbcritic on Sat Feb 11, 2017 01:30 AM
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Legally
 as of Jan of this year, it should be much tougher for a company to
simply disappear with regards to posting results of finished trials https://www.statnews.com/2016/09/16/clinical-trials-reportin

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Tue Feb 14, 2017 09:10 PM
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Happy Valentine's Day  everyone!

D has set such a great tone of love and compassion on our thread that
 it seems such an appropriate date to post. His research efforts and his
 personal devotion as a caregiver have set an example to all of a love
filled life.

I have been reading some very exciting metabolic cancer research and
have been carefully contemplating the events of the last year. I have
concluded that the fundamental message of our thread of propounding the
virtues of cancer metabolics is as valid as ever. There is so much
unexplored potential on this horizon it is truly bewildering that it has
 not been examined in more detail.

One group that is exploring this landscape is Dayspring. They are now
 reporting another patient. This patient is dated Feb 2017 and has stage
 IV bile duct cancer. I am unsure whether some of these patients would
even be treated elsewhere. It is highly impressive that Dayspring has
consistently reported patients that from the reports provided seem
almost unhelpable. (Of course, they are selecting which patients are
reported.) We would really love to hear from patients who might have
been treated at Dayspring with 3-BP. Perhaps  you read our thread and
this helped you decide, please post we would all really love to hear
from you.

I also impressed by the integrity Dayspring has shown by staying with
 3-BP treatment when it would be so much easier to move into another
treatment. Dayspring probably has one of the best understandings of
anyone in the world of the clinical effectiveness of 3-BP and it is
reassuring to see that their clinical experience supports continued use.

Feel the love!

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Tue Feb 14, 2017 11:43 PM
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This one has several statements that really jumped off the page for me.

"It is to be noted that many studies have shown that cells with
aerobic glycolysis have a clear proliferative advantage over cells that
use mitochondrial oxidative phosphorylation "

To what extent might the strategy of cancer be to simply starve
normal cells of glucose? It is true that glycolysis is not efficient
versus OXPHOS, though with cancer consuming up to 200 the glucose of
other cells perhaps it is simply a strategy of gobbling up all the food
in sight perhaps forcing neighbouring cells to evolve in the same
direction. Not sure if they considered this idea within the concept of
their theory.

They developed a theory that Warburg's effect might be the driver of
cancer. With one metabolic driver as :"the teleological reason for
recruiting of α-ketoglutarate as a cosubstrate to regulate the activity
of HIF1"

"metabolic plasticity is a built-in feature that allows even normal
cells to acquire aerobic glycolysis under many physiological
conditions."

They are pushing a Warburg plus effect "the initial event in sporadic
 cancer is the fortuitous shift to aerobic glycolysis, which then
provides a unique environment for cells to proliferate rapidly and
evolve in a cooperative fashion."

Love to see some lab research that could mimic cancer in the lab using this approach.

"in principle, Warburg effect, once initiated, can substitute for a mutation"

"indicates that fluctuating levels of α-ketoglutarate can drive a cell to a new phenotype purely due to noise in the system."

"a fortuitous metabolic shift followed by epigenetic modification and
 genetic alterations seems to be the sequence of events that occurs in
cases of sporadic cancers. "

"the role of hexokinase II (HXKII) and glucose metabolism in aerobic
glycolysis is highlighted by the observation that H-19 hepatoma cells
produce more lactate when glucose is used as the carbon source as
compared to galactose. Consistent with this, HXII protein, an apoptotic
suppressor, is associated with mitochondrial fraction only when glucose
but not galactose was used as the carbon source,

INDICATING that apoptotic suppression is specific to glucose metabolism "

That one really leapt off the page for me. Apoptotic
suppression is specific to glucose versus galactose metabolism? I would
need to read up on that one. Could apoptosis be encouraged by simply
switching to galactose?

"can also explain the phenomenon of reversion of cancer cells to
normal cells " Very startling! Cancer cells can revert back to normal
cells?

"more than 90% of ovarian cancer is due to ovulation-induced wound repair"

The far reaching position of the article:

"because of noise, a stable glycolytic phenotype can be manifested
and propagated during cell division in normal cells, independent of
genetic or epigenetic event, provides a conceptually new avenue that
would radically alter the way we think about cancer. "

Cancer that could be independent of genetics, the thread has taken a
weaker take on this by often suggesting that genetics is downstream of
the driving process. This article is putting forward the seemingly
radical proposition that cancer or a precancer state could exist in
normal cells due to a stable glycolysis created from noise in the
biological system.

"a cancerous state as one of the aberrant developmental options available to a normal cell"

https://www.ncbi.nlm.nih.gov/pubmed/22704333

A very thought provoking article.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Wed Feb 15, 2017 07:42 PM
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critic, the article that I just posted resolves
the chicken and egg question in a fairly unique way, there is no chicken
 and egg! The article is proposing that a cancer phenotype could
spontaneously emerge simply noise in the biological system. They suggest
 that this could push cells into a stable hyperglycolysis state without
the need for genetic or epigenetic drivers. This would seem to be a new
and innovative departure from the current accepted wisdom.

Yes, chris I think greater transparency about results from 3-BP
treating clinics should be forthcoming. If clinical trials are not to
begin in the near time horizon, I am unclear why such disclosures are
not a legal requirement.

We have learned from the Bracht investigation that a substantial
number of patients were treated with 3-BP there (perhaps more than
100) and apparently few if any actually saw a benefit from their
treatment. I am not sure why this has not been more fully reported and
investigated by the media and investigators. Regulators allowed this and
 other clinics to continue treating patients, while tacitly permitting
efficacy claims on the clinic websites. At the same time this treatment
did not help the patients.

3-BP is a maturing treatment and fuller disclosure of clinical
activity should be required. It would be very helpful if the Right to
Try activists were to advocate for such disclosures. Many people have
succombed to illnesses all the while seeking treatments from clinics who
 would reasonably have been expected to know such treatment would be
futile. Where is the rage?

I was also thinking that the idea of an initial treatment with
sub-therapeutic 3-BP dosing should also be encouraged. 3-BP is a fairly
unique treatment in that it can show very rapid effectiveness. Many
people including some on thread likely would be willing to pay for 3-BP
if it were known to be effective before a substantial bill was due for a
 full round of treatment. 3-BP clinics that offered such a treatment
plan would be showing good that they believed in their product and were
focused on the best interests of their patients. We should also be
advancing this concept which has now been discussed on thread of years.

I would really love to hear from the stage IV bile duct cancer. We
have been through a lot of grief with what happened at the Bracht
clinic, it would be so uplifting to hear some success stories. I am sure
 you must be familiar with our thread, please post!

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Meech90 on Wed Feb 15, 2017 07:48 PM
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On the note of glycolysis and apoptosis suppression:
 it can be logically assumed that in cells in cells with mutated or
inactivated p53 (large amount of cancers, over 50%), that mdm2 is
activated since activation of mdm2 suppresses activation of p53. mTOR is
 an activator of mdm2. mTOR also activated HIF1-a.
p53 is a tumour suppressor protein. During the cell cycle, if there is
cell damage, p53 halts cell cycle progression in the G1-S phase and it
attempts to repair the damage. If damage is successfully repaired, it
allows the cell cycle to continue as normal, but if the cell cannot be
repaired, it initiates apoptosis. You can see where the mutation or
disabling of this gene could lead to infinite replication among cancer
cells.
This is all part of the PI3K-Akt-mTOR pathway, and this pathway is
enabled by either PTEN being knocked out or via a mutation called
PIK3CA.
I'm not sure how many cancers exhibit mutations in the PI3K-Akt-mTOR
pathway but it certainly is not all of them. This could be one partial
explanation of why glycolysis can lead to suppression of apoptosis. mTOR
 can encourage both glycolysis through activation of HIF-1a as well as
suppression of apoptosis by indirectly shutting off p53.
This is all hypothesis by me by the way, so take it with a grain of salt
 haha.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Meech90 on Wed Feb 15, 2017 07:49 PM
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Sorry about the lack of formatting. I typed it on mobile and I guess the line spacing wasn't recognized.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Wed Feb 15, 2017 08:22 PM
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Meech, thank you for posting.

Yes, cancer appears to have strategically switched to glycolysis
partly to prevent the apoptosis inititation mechanism of mitochondria.
In recent research it was found that mitochondria can circulate in the
blood stream. Would be very interesting to know whether injecting
functional mitochondria into cancer patients might show efficacy.

I was also glad to read more about HIF-1. As you mentioned and also
in the recent article I cited there are important feedback loops with
HIF-1.

Starting from the basic metabolic machinery layers of feedbacks loops
 accumulate. Considering that life most likely began as not much more
than glycolysis and DNA greatly clarifies what is truly the essential
essence of cancer.

Don't worry about formatting, there is no edit function here so it is best to just let typos happen.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Wed Feb 15, 2017 08:31 PM
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Go Oz Go!

Wow!

"In less than 20 minutes the tumour had gone purple then black"

https://www.qbiotics.com/index.php/public-relations

This is only for intratumoral and is only in phase 1 though it is impressive.

D, how might they be able to convert this to a systemic drug?

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Wed Feb 15, 2017 08:48 PM
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I elect ernemef, to go up to the mangrove swamps
of Northern Queensland and locate some seeds from the Blushwood tree.
Erne, mind the crocs up there, there's some mighty big hungry crocs in
those swamps.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Wed Feb 15, 2017 09:56 PM
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Click on the 3D model Jmol interactive image link to see it. https://en.wikipedia.org/wiki/EBC-46

Molecular Formula C30H42O10.

Appears to have truly profound anti-cancer properties limited to intratumoral injection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182759/

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by dumbcritic on Thu Feb 16, 2017 03:09 AM
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G100 is administered intratumorally. The first group had three
patients in it and all had locoregional stage IIIB merkel cell
carcinoma. The drug was injected on days 0 and 7 followed by surgery on
day 28. Two of the three are still recurrence free at months 19 and 23
and the other patient had a pathologic complete response. In the second
group then seven patients had stage IV. This was injected on days 0, 7
and 21. It was followed by optional treatment cycles in months 2-4. If
patients had this then on day 0 they got a single fraction of 8 Gy of
radiotherapy to one tumour followed by injections on days 1-3, 7, 14 and
 35. Two of the seven patients have had reductions of their tumour
burden by 30% or more and responses are ongoing (17 and 18 months). Most
 of the side-effects were mild http://www.immunedesign.com/wp-content/uploads/2016/06/MCC-A This can be combined with other IT treatments like IL12 http://www.immunedesign.com/wp-content/uploads/2016/04/2016-
 SD-101 is another agent that is administered intratumorally. In this
trial they recruited 28 patients with biopsy-confirmed, untreated,
low-grade B-cell lymphoma (follicular, marginal or chronic lymphocytic
leukemia/small lymphocytic lymphoma) with lymph node involvement
(appropriate candidates for watch and wait). Most of them had stage III
or IV follicular lymphoma. On days 0 and 1 they all got 2 Gy of
radiotherapy followed by injections on days 1, 8, 15, 22 and 29. Around
70-75% had reductions in their tumour burden. For most patients the
responce has been durable ranging up to almost day 600. Three patients
had a partial response (PR) and1 had a complete response (CR) as
measured by Cheson criteria. http://files.shareholder.com/downloads/DVAX/2548598851x0x921

Rose bengal (PV-10) has been used IT for HCC and liver mets http://provectusbio.com/media/docs/publications/CIO%202017%2

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by ernemef on Thu Feb 16, 2017 08:15 AM
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Thanks
 J for your faith in my ability to undertake such an honorable task but
regretfully I'm afraid I must decline. I am still recovering from a
recent trip to Lisbon to have a PAE (prostate artery embolization)
performed by Professor Pisco on my prostate cancer. He has done 29 so
far. I would have been number 30 but although all external tests were
propitious, once they were inside unfortunately my prostate artery was
found to be too narrow for their catheter and so the operation failed
much to my regret, and I have had to return to Australia much lighter in
 the hip pocket.

As well as the embolization I would have received a mini dose of docetaxel directly into the prostate at the same time.

I think we are going to see a lot more prostate PAEs done in the near future.

Obviously the procedure could be adapted to 3BP once it is proved safe and maybe even the mangrove swamp berry extract as well.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by peggyznd on Thu Feb 16, 2017 06:12 PM
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The blue scorpion venom is not tested in any
clinical trials, and is not apparently of any interest to others than
those who sell it.  Must say that this is not likely to give benefit,
but wish it were possible to kill tumors so easily.  If it were the
case, some pharmaceutical company or academic center would be breeding
these scorpions and creating a meaningful product.

There are often 'active' ingredients which work in a petri dish or
seem to help an individual or two, but without real studies, this type
of reporting is quite unreliable.  Sorry to have to remind us.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Thu Feb 16, 2017 07:59 PM
 Quote | Reply

Thank you very much for posting, ernemef!

Seems like everyone has more interesting things to write than I do. I
 am more of a talker than a listener, though it is often instructive to
pay careful attention to what others say when you need to inhale.

Prostate TACE? Is this a new one? D suggested that TACE could be done
 nearly anywhere in the human body. I wonder if the conceptual idea of
controlling cancer and converting it to a truly chronic life long
illness by simply TACEing all the major organs might be valid. Patients
might wind up with large cancer burdens while at the same maintaining
good overal organ function.

The Blushwood tree treatment seems ridiculously powerful as an intratumoral injection.

*"Usually when you treat a tumor it takes several weeks for it to
resolve, but this is very, very rapid. There’s a purpling of the area,
of the tumor itself, and you see that within five minutes and you come back the next day and the tumor’s black and you come back a few days later and the tumor’s fallen off.”*

http://naturalsociety.com/blushwood-berries-kill-cancer-75-c

Wow! These were the results that they found with almost 200 animal
patients. The two phase 1 clinical trials are finding similar results in
 people. Would really love to see whether this might be transitioned to a
 systemic treatment.

"If this goes well, there is potential for treating internal tumours where injection can be guided through imaging processes."

http://www.ucansurvive.org/editor/assets/qimr\_articles/natur

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Thu Feb 16, 2017 08:33 PM
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Anyone notice that someone known to our thread has an article published? Well done.

CELLULAR ACIDIFICATION AS A NEW APPROACH TO CANCER TREATMENT AND TO
THE UNDERSTANDING AND THERAPEUTICS OF NEURODEGENERATIVE DISEASES

The article discusses the role of the acid/base balance within and outside of cancer cells as a regulator of cancer survival.

I was very impressed by the article I recently cited that tried to
focus on the emergence of hyperglycolysis as a cell state that could be
stably maintained even without genetic changes merely due to cell noise.
 It is hard to know for sure, though the above article appears
to provide a solid framework to consider that the acid base relationship
 might be an equally fundamental driver of cancer cells possibly in a
more intuitive manner (while this is probably intereconnected) than even
 hyperglycolysis.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Thu Feb 16, 2017 08:47 PM
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Would have liked to see the article mention ACCA.

"Highly malignant tumors rely heavily on aerobic glycolysis
(metabolism of glucose to lactic acid even under ample tissue oxygen;
Warburg Effect) and thus need to efflux lactic acid via MCTs to the
tumor micro-environment to maintain a robust glycolytic flux and to
prevent the tumor from being "pickled to death ... a small-molecule
inhibitor alpha-cyano-4-hydroxycinnamic acid (ACCA; CHC) to show that
inhibiting lactic acid efflux is a very effective therapeutic strategy
against highly glycolytic malignant tumors" wiki Monocarboxylate
transporter

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by zmkdr on Thu Feb 16, 2017 09:58 PM
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I tried blue scorpion venom during the month of January with no effect. I actually progressed.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Fri Feb 17, 2017 06:28 PM
 Quote | Reply

Thank you very much for posting, ernemef!

Seems like everyone has more interesting things to write than I
do. I am more of a talker than a listener, though it is often
instructive to pay careful attention to what others say when you need to
 inhale.

Wow, prostate TACE!
Is this a new one?

D suggested that TACE could be done nearly anywhere in the human
body. I wonder if the conceptual idea of controlling cancer and
converting it to a truly chronic life long illness by simply TACEing all
 the major organs might be valid. Patients might wind up with large
cancer burdens while at the same maintaining good overal organ
function.

The Blushwood tree treatment seems ridiculously powerful as an intratumoral injection.

"Usually when you treat a tumor it takes several weeks for it to
resolve, but this is very, very rapid. There’s a purpling of the area,
of the tumor itself, and you see that within five minutes and you come
back the next day and the tumor’s black and you come back a few days
later and the tumor’s fallen off.”

These were the results that
they found with almost 200 animal patients. The two phase 1 clinical
trials are finding similar results in a small number of people. Would
really love to see whether this might be transitioned to a systemic
treatment.

"If this goes well, there is potential for treating internal tumours where injection can be guided through imaging processes."

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Fri Feb 17, 2017 09:14 PM
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It has only now occurred to me that the two
patients reports for 3-BP that we have endlessly referenced on thread
did not report on why these patients responded so profoundly to
treatment.

Hopefully any future articles on 3-BP published patients will have
detailed reasons for why one patient might have responded, while another
 patient did not respond. In this genomic age it would not be
unreasonable to expect full genome sequencing of the patient's somatic
and cancer cells. Having such details would be of great benefit as this
would give prospective patients even greater insight into their
liklikhood of responding and inspire them to seek 3-BP if it were felt
to have particular potential for a particular patient. It might also
allow for manipulaiton of a patient's biology to increase the chance of
success.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by mikeadams on Fri Feb 17, 2017 10:03 PM
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From this https://sciencebasedmedicine.org/3-bromopyruvate-the-latest-

''As I pointed out with DCA, the widespread use of 3-BP leading to
complications such as these deaths of patients under Ross’ care could
endanger its clinical trials and approval. After all, what companies or
venture capital firms would want to partner to fund studies of 3-BP
after this news? If 3-BP is really an effective anticancer treatment in
humans, this recklessness on the part of alternative cancer clinics
could deny cancer patients a truly effective drug by tainting it with
their association.''

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Fri Feb 17, 2017 11:35 PM
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mike, thank you for posting.

Welcome aboard!

Always great to have someone new to the discussion with a fresh
outlook. Posters do not have to agree with the main narrative of the
thread here, though those with dissenting opinion need to point to
evidence instead of rhetoric to gain the confidence of the thread.

Yes, the sciencebasedmedicine does have a strongly articulated stance favoring the scientific method.

However, for a site that is strongly orientated to factual reporting
there are some statements made in the above url needing rebuttal.

For example, as we have discussed on several occasions on this thread
 the treatment effect seen in the melanoma patient cited on sbm was not
"minimal". Combination of 3-BP with paracetamol produced a profound
anti-effect after two combo treatments. The patient's LDH went from 4500
 to 12. I simply do not see how this can be dismissed. Such a dramatic
decline constitutes a metabolic cure.  See pubmed: 24636230. Notice on
the far right of Figure 3 that LDH levels approach 0 after the 2nd combo
 treatment.

It is also unclear to me why the sbm site goes on at length
describing how truly hopeless the liver patient's plight was. There did
not seem to be any available options, the patient was in an acute
terminal stage of cancer and 3-BP consistently had profound anti-cancer
effects. We have also noted on several occasions on thread that the
demise of the patient could with some justification be understood to
have resulted from focusing too heavily on his cancer and not enough on
his liver function. The sbm goes on and on with these long extended
quotes: all of which boil down to the patient was profoundly sick; 3-BP
had a profound anti-cancer effect. Do they think that we do not know how
 to read?

Also the comments from the url are no longer avaiable. One
interesting comment that was made was that sbm vehemently denied that
the article was suggesting that 3-BP was quack medicine, instead that it
 was medicine treated by a quack. There is a large distinction and they
wanted it to be clearly known that even though quack medicine and 3-BP
were often used in the same sentence that it should in no way imply that
 they believe that 3-Bp is quack medicine. OK?

Given the ongoing depth of research that continues to accumulate
behind 3-BP, it becomes ever less credible to suggest that 3-BP is in
fact quack medicine.

sbm also describes Dayspring as a quack clinic. At the same time
Dayspring has continued to post 3-BP success stories with patients that
in fairness would seem to truly have no available options.
Also of note is that MD Anderson, widely considered the
world's premiere Cancer Center (therefore, not a quack clinic) has
developed a slightly modified version of 3-BP called 3-BrOP
and has reported some equally impressive preclinical results with it.
Not much has been heard of it though of late.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Sat Feb 18, 2017 10:38 PM
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Very exciting!

I have spent the day firming up my understanding on the mechanism
behind DCA. D's site has a great review from earlier in the year and his
 article motivated me to learn more.

The translational research continues to role out for DCA. The role of
 GSTZ1 genotypes, the importance of upregulating SLC5A8 , a new
formulation that is emerging (diisopropylamine dichloroacetate), and
also a chitosan-dichloroacetate (CSDC) formulation are all helping to
move DCA forward even more than 10 years since its debut. A similar path
 of incremental development might also emerge for 3-BP.

One question: How might upregulating Pyruvate dehydrogenase phosphatase (PDCP1) fit into DCA treatment?

DCA turns Pyruvate dehydrogenase (PDH) back on by turning Pyruvate
dehydrogenase kinase (PDK) off. With PDH on, pyruvate can continue along
 the normal metabolic path to acetyl-CoA and onward to the TCA cycle and
 then OXPHOS.

Pyruvate dehydrogenase phosphatase (PDCP1) also reverses the
phosphorylation of PDK. DCA and PDCP1 both turn down PDK activity, so
perhaps it might be worthwhile to increase PDPC1.

Also wonder about the newly discovered mitochondrial pyruvate
carriers. Might increasing MPC activity in order to move pyruvate into
the mitochondria be helpful to fuel up OXPHOS?  PMID:27911865 Appears
that cancer has used this for metabolic reprogramming.
Felt really great to develop a firmer understanding of DCA. today. Very
encouraging to see all these products moving closer and closer to the
goal line.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Sat Feb 18, 2017 10:49 PM
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I just have to post this one.

Anyone care to guess how many journal articles were published in 2000
 came back as hits for "Warburg effect" AND (cancer or tumor)?

0!

We might now all take the "Warburg effect" as a near central truth
about cancer, though this is only a recent trend. It has only been in
the last 10 years that there has been an enormous interest develop in
it. Probably in fair measure as a result of DCA and then 3-BP.

Difficult to understand that the scientific community would be so
fixated on the latest fads and nearly entirely neglect what our thread
understands as an integral component of cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784299/

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Sun Feb 19, 2017 01:19 PM
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Speechless!

PMC4440852

Phase 1 clinical trial started last March .

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by peggyznd on Sun Feb 19, 2017 03:51 PM
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Where is the reference to the Phase I clinical trial?  I can't findit, but do get led to a series of studies.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Sun Feb 19, 2017 04:27 PM
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Very startling! In the article the tumor volumes went to zero and stayed there. I never remember seeing that before.

Active ingredient appears to be synthetic cyclic dinucleotide (CDN)
derivatives. Cyclic dinucleotides are basically two nucleotides attached
 through the phosphate group.

One can only hope that we will soon enter an era in which home
remedies for serious medical conditions can be discontinued. Go pharma,
go!

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Sun Feb 19, 2017 11:23 PM
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ernemef, just reading about this one and I was
thinking of you. Heard of Bipolar Androgen Therapy? Aften the CDNs
everything seems like a home remedy, though perhaps you might be
interested.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Wed Feb 22, 2017 01:51 PM
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2DG and fenofibrates.

https://www.sciencedaily.com/releases/2016/05/160518141255.h

There is a fair amount of excitement on D's site over citrate. It is
truly amazing how many points along the metabolic pathway are available
for manipulation. It would be well advised for all of us to carefully
reflect on how energy is used by cells and how these steps are
regulated. The answer seems to be right there.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Wed Feb 22, 2017 10:01 PM
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Very exciting everyone. There is a real ah ha
type moment out there putting together citrate and the other
anti-metabolics into an integrated approach treatment strategy.

I think this has been mentioned on the thread before, though I have
only recently looked at this one more carefully. Calithera is working on
 a glutaminase product that can hugely reduce its activty (pdf below
seems to suggest 100%?). Combining a pharmaceutical such as that with
other metabolic interventions could significantly increase
effectiveness. Glutamine as several important functions that are of
interest to our thread.

http://www.calithera.com/wp-content/uploads/2016/11/Phase-1-

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by kbmac on Thu Feb 23, 2017 01:33 AM
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Please send  me the link to chinese source of 3BP.  Thank you

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by kbmac on Thu Feb 23, 2017 01:36 AM
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Please send me the chinese contact to purchse 3BP.  Thank you.

Karen

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Meech90 on Thu Feb 23, 2017 06:08 PM
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The
 main exciting news for me here is that safe dosages of glutamine
inhibitors are being tested. I feel like a much better strategy can be
thought of than solely the one that the trial was testing.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Meech90 on Thu Feb 23, 2017 06:12 PM
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By blocking the PI3K/mTOR/Akt pathway, I would
assume that you're conditioning the cells to be more sensitive to
apoptosis through eliminating a pathway that tends to block p53, and
blocking an escape mechanism from this pathway seems to doubly do that. I
 would think adding a cytotoxic chemotherapy to this protocol would
yield some promising results. Especially since the majority of patients
experienced tumour progression arrest, indicating that the combination
therapy was sufficient to block the tumour's metastatic and
proliferative properties but was largely unsuccessful at inducing
apoptosis.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Thu Feb 23, 2017 09:39 PM
 Quote | Reply

Meech, you are so correct. Often with cancer
trials they are testing a drug in a way that could never be shown
effectiveness. Perhaps the rule that drugs need to show efficacy as
single agents should be relaxed.

I was not clear about what I meant about the ah ha. This was meant to
 express my appreciation of all the other metabolic targets out there.

I have been very focused on 3-BP and have not been as aware of the
others as I should have been. There is a whole list of them. 3-BP, DCA,
ketogenic diet, sodium fluoride (applicable to humans?), citrate, alpha
lipoic acid and hyroxycitrate, and on and on. D's polypharmacy approach
makes so much sense. Others should be aware that rotating through them
until finding something that creates a response is a fairly good
strategy.

Wonder when a clinical trial might start up based on this idea.
Instead of a trial with one or two agents, why not try a basket full?
The end point would be best response. One of the great parts of many
metabolic approaches is that knowing whether a response will or will not
 occur often can be discovered very quickly. Often people will stick
with something even when it has not been shown to be effective.

I have been reading through quite a few articles of late and these caught my eye.

Passenger Deletions Generate Therapeutic Vulnerabilities in Cancer

The example given in the article is ENO1 and ENO2 from  glycolysis.
Article notes that often a cancer gene can be mutated and along with it a
 nearby gene such as ENO1. This would not cause a problem for the cancer
 because there is a backup copy with ENO2. Together they are essential
genes, though when one is mutated the cell can carry on. Now if the
backup copy is also inactivated by a pharmaceutical, the cancer cell
cannot carry on, while the normal cells can lose ENO2 activity and still
 have a backup with ENO1.

That's pretty neat thinking.

Identification and characterization of essential genes in the human genome

This article found that there are about 2000 essential genes.

Might be worth doing a moon shot, finding all the genes that have
redundancy and finding a blocker for all of them. Cancer cells that had
one of these missing would be unable to survive if the other one were
blocked. This would be all the more true of later stage cancers that
had a greater tumor burden. It would also be true of e.g. melanoma which
 is known to have a very high mutation burden compared to other
types.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Fri Feb 24, 2017 09:18 PM
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Something has put into perspective what we have
been trying to achieve on our thread over the last four thousand, 2
hundred and fifty posts.

The lastest pubmed article that is pulled up by a search for 3-BP is
PMID:27938509. This article begins by noting that liver cancer (HCC) is a
 leading cause of cancer mortaility worldwide. PMID:25651787 calls liver
 cancer the number 2 global cause of cancer mortailty.

Most of these patients are not diagnosed until a late stage of the
illness. At which point there is only one FDA approved option:
sorafenib. Sorafenib was approved in 2008. The partial response rate is
2%. Sorafenib was found to increase median survival by 2.8 months.
The article then described what happened when they combined sorafenib with antiglycolytics including 3-BP in cell culture.

They tried 3-BP, it was not effective in combo.They tried Gossypol, it was not effecitve.They tried lmatinib, it was not effective.They tried Lonidamine, it was not effective.

They tried 2DG, it was effective.

"This profound decrease in cellular-ATP level was observed in both parental and sorafenib resistant Huh7 cells."

The authors talk about moving this one further along in the research pipe.

This
 article highlights for me the substantial potential of the metabolic
approach to help many people who are coping with metastatic illness.
This is all the more true when you compare the Global Cancer Statistics
article noted above to the version of the article quoted in the above
described research from the year before.

As can be seen by such a
comparison we are now in the midst of a global cancer pandemic. It is
urgently necessary to try innovations such as what is reported with the
anti-glycolytic combination. Otherwise the numbers are going to continue
 to increase exponentially. (It is somewhat surprising though that this
research is being reported 10 years after the approval of sorafenib.)

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by ernemef on Sat Feb 25, 2017 12:10 AM
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Jcancom,
 yes I have heard of it but was switched off from reading up on it by
the words Androgen Therapy which I am averse to. Now that I have had a
proper look at it I am certainly interested though it is still very
experimental and far off clinically I'm afraid, but a step in the right
direction.

Here are a few comments:
A New Prostate Cancers Treatment Strategy – Part 3 of 3

Bipolar androgen therapy is probably not for “men who have not yet
had any treatment for prostate cancer”. Moreover, the long-term effects
or dangers of the therapy aren’t yet known. Only longer, larger trials
will mitigate uncover any risks associated with the treatment. And one
expert worries that alternating testosterone levels could actually
shorten men’s lives. “A cancer cubicle could escape and grow, as
happened in breast cancer when this method was tried with estrogen,
causing early death,” said Dr Anthony D’Amico, chief of radiation
oncology at Brigham and Women’s Hospital in Boston. D’Amico agreed with
the think over authors that bipolar androgen therapy is not ready to be
used in clinical practice and doctors should wait for the results of
ongoing trials before gift it to men.

The promising developments always seem to be just over the horizon.
Maybe however the time is nigh for banishing the bogie of testosterone
in prostate cancer. A few studies have shown that patients with high
levels of testosterone survive longer than those with low levels, though
 I can't recall where I read this. Professor Morgentaler (Boston) has
for many years been thinking along these lines..

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by dumbcritic on Sat Feb 25, 2017 06:12 AM
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A new paper: Press-pulse: a novel therapeutic strategy for the metabolic management of cancer http://nutritionandmetabolism.biomedcentral.com/articles/10.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Sat Feb 25, 2017 02:20 PM
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Good one critic! The article was very well
written and pulled together many of the ideas that have been of long
term interest of the thread.

I think it might have been helpful for the article to have included
the idea of cycling through various anti-glycolytics. I do not think the
 article was explicit in this regard, though mentioning several in the
class (including 3-BP) might be understood to imply this.

Something that has perhaps not been talked about enough in the cancer
 as a metabolic illness conversation is mitochondrial replacement
(mitophagy). The article went into depth discussing the deficiencies in
mitochondrial function related to cancer. A simple minded rebuttal would
 be if cancer is caused by defective mitochondria, then why
not make more mitochondria (hopefully ones that are not defective). See
url below starting at post #127.

As a reply to post #127:

"But since mitochondria are already shut down, I don't see the point
of an anti-mitochondrial in general, especially as that might damage the
 entire organism."

Doing a mitochondrial reset and eliminating "zombie mitchondria"
might allow for mitogenesis to create functional mitochondria.
Functional mitochondria could then undergo apoptosis. I am not sure,
though, whether functional mitochondria would emerge from this process.

It is interesting to note that PQQ, niacin and others mentioned in
the Longecity thread do have anti-cancer activity. However, it is not
clear to me whether this is related to the mitogenesis pathway.

Also very interesting about NAD+/NADH ratio. They are involved in
mitogenesis reset and these chemicals are also involved in the rationale
 for lactate?

http://www.longecity.org/forum/topic/86297-a-protocol-to-upg

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Sat Feb 25, 2017 06:02 PM
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Dear ernemef: I am so glad that you are in that
class of cancer patients that can be more circumspect and demand a
higher level of evidence. Bipolar Androgen Therapy is counter-intuitive
and one would want it to be more consensus than controversial before
putting one's toe into the water.

Ideally the same would be true for all cancer patients.
n=1 experiments may or may not be much more helpful than n=0
experiments. Yet, upon the onset of metastatic illness, usually after
extensive traditional therapies have been tried, then non-approved
sometimes are almost the only option which has been a focal point of the
 thread.

I was quite stunned by the liver cancer statistics. I had not fully
appreciated the global magnitude of the problem. The latest
statistics noted three quarter of a million deaths in 2012, perhaps a
million or more this year. And all there is is sorafenib? It took 10
years to think of 2DG?

We need more Warburg thinking!

You really do not need to be a genius, all we need is a conspiracy to
 tilt the conversation to metabolics. We can simply sideline others by
changing the vocabulary. Those who were not talking in metabolese would
be the out crowd. In a Tower of Babel scenario, one can simply win the
argument through force of demography.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Mon Feb 27, 2017 08:54 PM
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Very exciting! A new 3-BP article.
PMID:28236852 Not
 really that new, I think we talked about this one a few months ago,
though it is great to see it now in pubmed. This one highlights the
considerable importance of GSH in 3-BP effectiveness. Several
interesting ideas emerged from the paper for me.1. possibly limiting
cysteine in the diet.2. possibly specifically targetting tumors for GSH
depletion. 3. use of GSH rescue therapy if trouble were to be
encountered with 3-BP. I noted the below url before. The highest dose
was able to greatly decrease glutaminase levels. This should reduce
glutamate levels. GSH needs glutamate to be synthesized. However, this
would not be tumor specific. What might happen to 3-BP safety with
maximal whole body GSH depletion?http://www.calithera.com/wp-content/uploads/2016/11/Phase-1-
 is encouraging to watch the ongoing accumulation of 3-BP research.
There is potential and admittedly risk involved with this. Perhaps
chitosan acetaminophen might help?

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Mon Feb 27, 2017 10:48 PM
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ernemef, very interesting article in the
forthcoming April volume of Medical Hypotheses. The hypothesis that is
presented is that prostate cancer results from menopause (somewhat
indirectly). Look forward to hearing your thoughts.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by ernemef on Tue Feb 28, 2017 06:56 AM
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Jcancom, for years I have been
 sucpicious of prostatic infection due to sexual intercourse as a cause
of benign prostatic hyperplasia and subsequentally prostate cancer,
largely due to the widespread nature of its occurrence. I used to
suspect a connection with vaginal fungal infections which are very
common, but my GP didn't think much of the idea. She is a woman after
all. However the menapausal connection throws new light on the matter.
Maybe, maybe. Unfortunatly once you have undergone the transformation to
 the cancerous state it doesn't help much what the cause was. I wonder
what the incidence is for homosexual men.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Tue Feb 28, 2017 06:20 PM
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ernemef, there has been so much great cancer news
 that I have been reading lately that I was thinking that we should call
 for a global "Cancer is nearly defeated" event for this weekend coming
up. With this news about BPH prehaps being pre-malignancy, the idea is
all the more relevant.

I had not realized how enlarged the prostate can become with BPH.
wiki shows it as this huge growth that covers much of the male
urogenital tract. If this were to be a simple infection, then treating
with curative intent could help us determine whether BPH does eventually
 progress to cancer. Considering the symptomatic consequences of BPH I
suspect that quite a few guys will now be visiting their doctors for
curative antibacterial/antifungal? treatments.

There would be a strong parallel to peptic ulcers and H.pylori .
 From what I understand BPH is now commonly treated more as a cryptic
inflammation than as an infection. This is how ulcers were always
treated. Simply treating the inflammation and not the infection probably
 did not help reduce the risk of stomach cancer, same would be true for
BPH. This is a very exciting development and is one of those times where
 you really have to wonder how this was not convincingly pieced together
 before. It has been sitting right there for us for decades and no
one could put it into words.

Amazing how much great news there is out there, most of which people
are largely unaware of. For example, it has been reported in 2015 that a
 H. pylori vaccine is safe and fairly effective. H. pylori is an
essential cofactor in up to 85% of stomach cancer which is currently one
 of the world's biggest cancer mortaility risks.

Also the report that you mentioned about 177Lu for prostate cancer.
Two clinical trials for this are opening up in the States. The
hypothesis about the menopausal link to prostate gives us the
possibility that in the medium term that most prostate cancer would
never manifest.

Report out today that the T-Car trial with Kite has shown almost 40% 6 month complete responders.

Blushwood Tree, immunotherapy, the cell results for 2DG + sorafenib, ...

There is enough good news out there for a celebration (in my opinion).

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by ipappas on Wed Mar 01, 2017 06:03 PM
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Hi J, thanks for keeping the thread alive !

If you noticed, the article you cited PMID:28236852 (do you have the
full-text?), is authored by Dr. El Sayed, who treated the patient with
metastatic melanoma in Egypt in 2014. He had used paracetamol to deplete
 tumor glutathione. This means he still believes in this approach and we
 may see more results coming!

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by ipappas on Wed Mar 01, 2017 06:28 PM
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Hi all, I don't know if you noticed the paper PMID: 28193528, co-authored by our dear friend Danielus! Congratulations!

It discusses at length (quite technical) the abnormalities of
intracellular alkalinization along with extracellular acidification
typical in solid tumors and leukemic cells and the relationship between
pH and the Wardburg effect. It reviews various cellular acidifiers that
have shown strong anticancer properties: Salinomycin, Metformin, DCA,
3BP, and others.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Wed Mar 01, 2017 11:18 PM
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Dear ipappas:

The 3-BP story continues and the research continues to pile up. The
basic story line continues to confirm the basic findings reported 15
years ago.

It is very exciting to see further investigation by the group who
treated the melanoma patient (read the article through a library). I
think there should be more such clinical reports that are followed up
with subsequent theoretical in the scientific literature. Sometimes with
 clinical reports there are large unresolved question marks that are
never addressed. For example, there is still a large mystery of why the
original liver patient treated with 3-BP responded in such a massive
way. It would be very helpful if this were to be answered.

Yeah, if we were to have another patient report, then I would
probably freak (as would many others on the thread). Many of the reports
 of 3-BP to date have been of very late stage patients, if they could
report on one who while late stage also had some reasonable expectation
that they could regain health then the entire nature of the discussion
would change. How ethical would it then be for end stage patients
without treatment options not to have freer access to 3-BP? That would
apply to the 8 million cancer patients who are not expected to see it to
 the end of the year. At the core of our years long 3-BP journey, there
has been lurking a profoundly absent sense of basic morality which is
not easily attributable to anyone or anything in particular.

The newly cited research clearly opens up a range of new clinical
avenues to extend the initial result. I am somewhat concerned though
about when normal cells might become vulnerable to knocking down GSH
with 3-BP treatment.

I just realized that the Ko group also have a GSH article
out PMID:27582536 from October. It is quite interesting to see how the
two groups wrote on the same topic, though had different spins.

With  PMID:27582536, I was interested in the finding that glutathione
 S-transferase is the enzyme that forms the 3-BP-GSH conjugates. Wonder
if you might be able to get around having to lower GSH levels and simply
 knock down  glutathione S-transferase. At least this might be
interesting to look at in cells.

The article also reported for the first time that 3-BP actually
upregulates GSH related genes. That is quite interesting. Some people
might introduce resistance to 3-BP by simply dosing up too slowly. The
GSH genes would increase and then oppose 3-BP.

Also like how both articles noted the importance of reducing GSH over
 simply upping 3-BP and consequently its risk. The Minimal Inhibition
Concentration decreased by up to 8 times by simply adding a GSH depletor
 in the earlier article.
These articles highlight for me how much of the so called informed
commentary related to 3-BP has instead been ill-informed. For example,
most popular reports on PMID:24636230 suggested that 3-BP had not been
successful. This is largely untrue. Figure 3 (at the right) shows a near
 disappearance in LDH. The current articles can shed some light on how
to interpret the Figure. When the LDH level fell by 25% (4000-->
3000) with a low dose of 3-BP, this should suggest that perhaps GSH is
countering the effectivenss of 3-BP. As more doses of mono 3-BP are
applied the LDH continues to decline to around 1500, perhaps a 60%
decline. This should give yet more hints of the opposing effect of GSH.
3-BP is working, it is entering the cell though there is some pushback
(perhaps GSH?). Then when the paracetamol is combined the LDH plunges to
 12! LDH has declined by 99.8%!!! It is a large stretch to consider this
 some great example of how 3-BP was ineffective, as was widely reported.
 3-BP needed a little help and then it had a massive effect. The October
 report noted, though that optimizing 3-BP once it has reached the
inside of the cell is not truly the real challenge. 3-BP has so much
inherent power to destroy cancer cells once in the cytoplasm that it
removing these blocks such as GSH really should not be overly strenuous.
 The big problem though is simply attaining cell entry.    Both of
these articles took months and months (approaching a year) to be
formally published. It does not seem unreasonable to me that these
articles could be added to pubmed once they are received and then
corrected/edited. I am not sure whether that is how it works, though 8
months seems a rediculously glacial time frame. Even the article that
has only been uploaded to pubmed within the last few days already seems
dated. For intance it does not cite the article also on 3-BP and GSH nor
 does it cite the article that researched the proteome and 3-BP. Having
such a highly deliberated publishing model results in research that is
hot off the press being somewhat stale.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Thu Mar 02, 2017 08:41 PM
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Early stage, though plausible. I think the thead
commented on this anti-malarial approach a few years back.

PMID:26461094

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Fri Mar 03, 2017 11:33 PM
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A long standing mystery on the thread is the
identity of tow liver patients treated with 3-BP as reported on the
Hopkins site. Might have found them.

The Ministry of Health in Israel granted permission for 3-BrPA
treatment "under the compassionate use protocol in two clinical patients
 who received the drug intra-arterially. In both cases, patients were
diagnosed with end-stage liver cancer (HCC and cholangiocarcinoma,
respectively). As a result, both treatments were technically successful
and no drug-related toxicities were recorded."
PMID:26989470

And as a followup to PMID:25569102 with
 the quite startling comment that ccRCC has a near absence of
mitochondria, there was this PMID:27418963. I have wondered if there
might be any interest from the ccRCC community in 3-BP.A fair amount of
3-BP research seems to be below the radar. Two of the above articles do
not pull up under a search for 3-BP. Is there a way to search pubmed
that would search articles for the text "bromopyruvate"?

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Sun Mar 05, 2017 02:32 PM
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Congratulations to Germany for upholding patient
choice and respecting fundamental human rights! Given German medical law
 it is no great surprise that the initial published 3-BP patient was
treated there, a point that has not been stressed enough on our thread.

No other nation allow for human treatment with little more than
pre-clinical mouse research. This innovation bottleneck is a central
feature of the minimal progress that has been made in biomedical
research.

The German recognition of the sanctity of the patient doctor
relationship outside of democratic inteference  demonstrates
a commitement to freedom. Further, allowing decisions to be made at a
local level creates an innovation driver (as was seen with 3-BP).
Central planning failed? Who knew?

With the massive amount of pre-clinical research that is constantly
being published, patients in need of innovative medical treatment should
 be aware that Germany might offer them options within their
established medical system that would not be available anywhere else in
the world.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Sun Mar 05, 2017 08:25 PM
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Interesting Germany has recently changed the
prescription status of 3-BP. How would a doctor write a prescripiton for
 a drug which has not been approved?

http://www.bfarm.de/SharedDocs/Risikoinformationen/Pharmakov

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Sun Mar 05, 2017 08:42 PM
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Finder, your help would be appreciated.

Does the above url imply that 3-BP is currently within the authority of the Pharmacovigilance Division of Bfarm?

This is confusing. The FDA would not convolute 3-BP with other
products in its Orange book. It appears that this is being done with
3-BP at Bfarm.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by dumbcritic on Mon Mar 06, 2017 08:38 AM
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I'm guessing it's due to what happened in Brüggen-Bracht. I wonder if compassionate use will still be allowed?

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Mon Mar 06, 2017 09:32 PM
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critic, I have also been thinking along
compassionate lines. Why have they stopped compassionate use? This seems
 very strange to me. The FDA went through a thorough analysis of the
evidence and concluded that a phase 1 clinical trial with 3-BP was
warranted. The clinical trial has yet to start after all of these years,
 though why not have a compassionate use program? Compassionate use
through perhaps Hopkins could would not need the formal structure or
cost of a formal clinical trial, though could gather valuable
information in terms of patient response etc.

Quite exciting to see that a second edition of Tripping over the
Truth was published last month. The narrative of the Metabolic thought
leaders that has been central to much of our online discussions has
largely been maintained.

I had started to wonder whether there might yet be a way to the goal
line for the Somatic Mutation Theory, though the book continues to
strongly rebut this theory. Book also notes that a metabolic clinic in
Turkey has applied many familars such as 2DG, DCA, ketogenic, etc. and
appears to report a fair amount of success. Love to know whether they
have also used 3-BP.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by entery on Thu Mar 09, 2017 03:50 PM
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Hi everyone!

Does anyone know about a clinic preferably in Europe, that can help me with getting a central venous catheter (port) ?

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Danielus on Thu Mar 09, 2017 04:20 PM
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Hi, most in Germany if you are sent by a doctor (e.g. from cancer private clinics).

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by entery on Thu Mar 09, 2017 04:30 PM
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Hi Daniel,

I would not be sent by any doctor, since it would not be used for any conventional treatment.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Danielus on Thu Mar 09, 2017 04:57 PM
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Hi Entery, that is why I mentioned cancer
treatment clinics - there are many in Germany - you could go to one of
thise a few times (one that has a Dr. not a Naturopath) and also ask the
 Dr. for a letter to instal a port-a-cath.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Danielus on Thu Mar 09, 2017 04:58 PM
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I meant a small private cancer clinic.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by entery on Thu Mar 09, 2017 06:15 PM
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Thanks Daniel, I will consider that. I have tried
 using peripheral venous catheter for some time now, but I don't think
it will work when I start with 2DG and 3BP.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Danielus on Thu Mar 09, 2017 06:22 PM
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You are welcome Entery. For 2DG I havent heard of issues but 3BP, to my knowledge, will be best with a port.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Thu Mar 09, 2017 06:51 PM
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entery, would be a very good idea to have some GSH on hand.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Sat Mar 11, 2017 03:52 PM
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Very exciting news!

FDA management is changing and with it the possibility that their
regulatory stance on issues that we have constantly discussed over the
last many years might actually budge. Probably most importantly there
can be at least a moment in which our state of consciousness can shift
and an important lesson can be learned: life does not have to be an
endless repeat of the past.

That is worth repeating! Life really does not have to be the same as it always was.

The FDA might finally be exiting Einsteins's insanity loop.

That is:

1. Fail

2. Go to back to 1

The fact that nearly all stage standardized solid cancer mortaility
rates have remained unchanged for at least 50 years has to be recognized
 as failure.

It is self-apparently true that if the FDA changes the rules of the
game wisely, then there will be a powerful wave of biomedical progress
that will clearly be apparent to the patient communities. Basically, we
will know that they made the right changes when the medicines of the
future finally move from the lab to patients. We'll have to monitor
whether this a real or cosmetic change.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Sun Mar 12, 2017 12:21 AM
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Been thinking about how FDA policy changes could
help move things forward.  Very excited! All this talk of moon shots and
 we are still on the launch pad even after a trillion dollars of
government investment. If they could simply adjust some of the rules,
another trillion dollars and still awaiting ignition would not have to
happen.

For instance, why not simply extend an unlimited Right to Try for
those who have life expectancies of at most a few months? Posters on our
 thread have talked about their fears of how treating their terminally
ill loved ones might result in professional misconduct charges applying
to those you were hleping them. Combining such an interpretation of
Right To Try with a Duty to Report would be a powerful innovation
driver. For instance, consider how this could drive 3-BP forward if of
1000 terminal cancer patients even 10 had a response even close to that
of the two published patients we refer to constantly on our thread.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Wed Mar 15, 2017 06:55 PM
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Appears to be some developing news on the Bracht investigation. The report is expected by the end of this month.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by peggyznd on Thu Mar 16, 2017 12:05 AM
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Jcancom, Re your reference to 3BP "even 10 had a
response even close to that of the two published patients". Concerned
that phrase may be interpreted by some readers to think that these two
patients were somehow cured, or had long-term benefit.

In the situation of the young liver cancer patient, he was thought to
 have died of liver failure, though no autopsy was done.  THat is not
the outcome that anyone wanted, of course.  He had had some limited
response to another FDA-approved drug, used off-label, but with the
first treatment of 3BP, went into a coma, and after a total of 9
treatments, went into liver failure and died.

Not exactly the response that we would want for other patients.  Let
us be more precise about what we know and not imply something that is
not factual.  This is too important to create misperceptions.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Danielus on Thu Mar 16, 2017 05:16 AM
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Dear Peggy,

Let’s not mislead people here, which I see you are constantly doing.

Regarding the liver cancer patient:

1. The published article is clearly showing the
effectiveness of 3BP in the case of the boy, a substance that extended
his life. This evidence is represented by at least two major
institutions of this world, i.e. John Hopkins University of USA and
Frankfurt University Hospital of Germany. Not to speak about the people
representing those institutions who each of them are world leaders of
both science and clinical interventions in their fields.

2. The father of the boy, a scientist himself, can
demonstrate step by step with impressive scientific evidence that 3BP
was extremely valuable for his dear son, and that was the reason why his
 dear son could live more. If you like to contact him, I am sure you
will find his contact details at the Dutch University he is working for

These are facts, no questions.

Now I am asking the people reading this, what
should we do? Listen to someone like you who constantly is trying to
push 3BP in to the negative light or listen to some of the best
scientist and medical doctors of this world.

The choice is in our hands on selecting the value
and filtering out the noise that is created by various people with
various reasons, believes or needs behind.

Let’s not forget, that as it was discovered some
time ago and shared with all here there is a Forbes article indicating
that every now and then, Peggy was financially supported by some of the
largest Pharma companies of this world. That tells me there is a
conscious  or unconscious bias is her judgement and statements.

The point is that I am a little tired of all this noise, intended or un intended.

Check the facts. Not the stories. There is both
scientific and clinical evidence published by some of the best of this
world showing the positive facts regarding 3BP. The rest is noise.

Kind regards,

Daniel

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by dumbcritic on Thu Mar 16, 2017 07:04 AM
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''Initial results with Sorafenib were
encouraging. Thus, tumor growth appeared to have halted during the first
 2 months of Sorafenib application, even with some regression of tumor
volume. However, after 6 months, CT scans indicated a renewed expansion
of the tumor’s mass, and Sorafenib treatment was halted. By now, the
health condition of the patient had deteriorated, in fact, so far that
he could not consume sufficient amounts of food to sustain life. On the
basis of this condition, a duodenal feeding tube was installed and
continuous (24 h) enteral feeding was started. The caloric intake was
adjusted to 2000–3000 kCalories per day.''

''Due to a large tumor burden at the presentation, it was determined
to try to obtain a very high dosing with 3BP in the first treatment
month. A second treatment was scheduled 2 weeks after the first, the
third after 4 weeks. After the second application (128 mg), which went
without any acute problems, the patient started to get disturbed. Four
days later, the patient went into a hepatic coma and was
hospitalized. The diagnosis was hepatic coma, which usually results in
death. It was suspected that the patient was undergoing a potential
tumor lysis syndrome (TLS) after three 3BP treatments. Without
additional help from the hospital, the patient was allowed to leave the
hospital by ambulance and transferred back home. After 4 h at home, he
began to show signs of recovery, and by nightfall, he was completely
back to baseline, with most of his mental capabilities functioning. The
recovery continued over the next day. The patient was able to consume
food and have social interactions with his friends, without any memory
of the comatic phase. The treatment team, in close communication with
the patient and his parents, and with their consent, decided to continue
 with the 3BP treatment as scheduled, with modifications in which the
blood chemistry was carefully monitored. Especially, ammonia, urea, and
potassium were added to the weekly schedule for monitoring. A medication
 for reducing blood ammonia in liver cancer patients, Hepamerz was
prescribed (6000 mg/day) and used for the patient as needed, but always
following application of 3BP.''

''Pre existing ascites and edema continued to be a major problem for
the patient, and despite daily exercise, his mobility continued to be
limited. However, during the summer of 2009 he started to regain his
physical strength and went out in his wheelchair regularly for a
promenade. In addition, the patient celebrated his 18th birthday at his
home surrounded by many friends and family members on September 9, 2009.
 The photo of the patient in Fig. 5 was taken on his birthday. At the
end of October 2009, a part of the discomforting ascites was removed by
CT-guided puncture. About 1 l of ascites fluid was removed and sent to
the pathology lab for cellular analysis. An outcome of an increased
lymphocyte count with some mesothelial cells, but no malignant cells was
 obtained. This lack of tumor cells in the ascites suggested that the
tumors in the liver were well encapsulated and dead. In December 2009
the edema and ascites were becoming more problematic. Liver functions
were overloaded due to rapid destruction of the tumor cells resulting in
 the liver’s inefficient detoxification. Despite regeneration of the
healthy liver cells, this process apparently could not compensate
adequately for the rapid destruction of tumor cells and could not
detoxify the dead cancer cell debris fast enough. Consequently, the
blood albumin levels were decreasing. The patient passed away 2 years
after his first diagnosis due to an overload of liver function. The
patient (Fig. 5) was able to survive a much longer period than expected
with an improved quality of life, which is clearly attributable to the
treatment with 3BP.''

Taken from the free PDF https://link.springer.com/article/10.1007%2Fs10863-012-9417-

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Thu Mar 16, 2017 06:02 PM
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critic, good one! Other commentators of 3-BP have
 pulled out a long quote from this article and then have created their
own interpretation based upon the assumption that no one will even
actually bother reading the quote (or the article).

Let the people read the article and decide for themselves! It is hard
 to imagine that anything but a favorable impression of 3-BP would
emerge relating to the treatment of this specific patient.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Thu Mar 16, 2017 06:07 PM
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I have actually followed my own advice and
several interesting aspects of the article came into focus for me. The
Sorafenib that they treated with (I have learned recently) has a 2%
response rate, where the responses typically appear to be short-lived
(28 days?). The patient in the article experienced tumor stabilization
if not perhaps a regression, though this might not actually qualify as a
 response (perhaps at least a 20% reduction is a more typical minimum).
Even still the patient continue to detiorate symptomatically.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Thu Mar 16, 2017 06:12 PM
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I was also interested in what they followed up with: TACE Gemcitabine and Cisplatin.

They performed one treatment but it was found that these chemos were
so cytotoxic that they decided against using them again. In fact, even
while the patient was now in an emerging end stage of his illness it was
 thought best to treat with no additional approved medications but
instead wait a month for authorization to treat with 3-BP. An immediate
bolus dose was give when this approval was authorized.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Thu Mar 16, 2017 06:21 PM
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I have been unsure on this point for years. Does
3-BP actually contribute meaningfully to the therapeutic options of
those patients who can undergo TACE? I mean how high a hurdle is it for
even a chemo drug to destroy cancer cells when you are essentially
delivering the drug directly to the region of the cancer?

Apparently this is a hurdle too high sometimes for chemo. The liver
patient received the standard of care to the book and even though he was
 in a near pre-morbid state decided to wait one month for 3-BP treatment
 while offering no other supplemental treatments.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Thu Mar 16, 2017 06:27 PM
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"The patient (Fig.5) was able to survive a much
 longer period than expected with an improved quality of life, which is
clearly attributable to the treatment with 3BP."

One of the authors of the article after the Bracht incident has
retracted the above statement. However, in carefully reading the article
 is very hard to understand why the statement would need to be
retracted: the above statement appears entirely consistent with the text
 of the article. The liver patient had been in a nearly constant
symptomatic decline for 9 months before starting on 3-BP. Yet, within
hours of the first 3-BP appears to have regained his appetite. He
continued to enjoy symptomatic benefits from 3-BP treatment for 11
months.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Thu Mar 16, 2017 06:39 PM
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I have been thinking lately of how the FDA could
demonstrate that they are sincerely interested in embracing meaningful
regulatory change. The idea of allowing for approval designations
without requiring efficicay demonstrations has been suggested. However,
it has occurred to me that 3-BP really does not need such a change: 3-BP
 could easily demonstrate efficacy measures if different measures were
allowed for approval. The reasoning being that proving long term
survival benefits would likely take a long time, probably years and a
large amount of money. If we were to move to an efficacy measure such as
 reduction in metabollicaly active tumore mass then that is something
that 3-BP can achieve within 15 minutes.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Thu Mar 16, 2017 06:47 PM
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Without 3-BP being given some level of officially
 recognized approved, we are stuck in the strange circumstance that
mainstream medicine sometimes feels that the best treatment option is to
 withhold all further treatment as noted above instead of offering their
 patients the most powerful known cytostatic drug ("The rate of tumor
necrosis due to 3BP treatment seems to exceed all known cytostatic
drugs" .) [quoted from the liver patient article] {Wouldn't cytotoxic be
 the more appropriate word than cytostatic?}

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Thu Mar 16, 2017 06:55 PM
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In terms of actual cure of long term response by
the liver patient or melanoma patient, no it is true that they did not
achieve this. However, these patients were specifically selected on the
basis that they did not have long term survival potential. Notably even
though both had truly large tumor burdens when 3-BP treatment started
neither of the patients appeared to have metabolically active cancer
detectable on their last labs.

Where I was going with if "even 10 had a response close ..." was that
 if you were to treat patients who actually had a functioning liver
(liver patient had 5% liver function) and a functioning lung ( melanoma
patient had perhaps 50% lung funciton) then you could start to see
unquestionable benefits in terms of survival etc. Apparently, the stage
IV lung patient treated with 3-BP from Columbia achieved these
milestones.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Thu Mar 16, 2017 07:01 PM
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Perhaps the real point of note is that the
patient benefited from his treatment. There is no way that I could
imagine that he would have been smiling on his 18th birthday photo
without 3-BP treatment. It seems nearly impossible to imagine that he
would have even be alive. The approved treatments that he received did
not even provide him with a short term symptomatic boost.

Basically, his response is exactly what we would want for others. The
 two patients had truly overwhelming responses. I totally agree this is
too important to create misperceptions.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Thu Mar 16, 2017 07:09 PM
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One aspect that some readers of the thread might
not be fully aware of is that the reason why he went into a coma after
the second treatment round is that TLS developed. TLS? 3-BP was so
overwhelmingly effective for this patient as an anti-cancer drug that
too many cancer cells were killed. 3-BP kills too many cancer cells?
First world problem? 3-BP is one of the first cancer drugs that you have
 more therapeutic index under the hood than you actually need. Same
problem in the melanoma patient: 99.8% reduction in LDH. Almost more
cancer destruction than is desirable at any given time. Liver patient's
demise is likely attributable to too much cancer destruction not enough
liver function.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Thu Mar 16, 2017 07:41 PM
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Sorry for hogging the mic, though it is one way of preventing others from just making things up.

Appears the possible outcome of the Bracht investigation is currently in evolution. We should know in about 2 weeks.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Thu Mar 16, 2017 08:20 PM
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That's interesting.

In the write up of the melanoma patient, they quote 2-3.5 mg/kg 3-BP
dosage from the liver patient article as their treatment guide. What is
strange is that the quote from the liver patient article is referring to
 3-BP TACE not IV.

Stranger still is that even with what appears to be an enormous dose
reduction, they still reported a 99.8% reduction in LDH production from
the tumor.

It would be of enormous help if a phase 1 trial could be done to help clarify such issues.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by peggyznd on Thu Mar 16, 2017 09:15 PM
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I stand by my statement that we must be careful
not to imply by any statements that 3-BP (or any other compound,what
ever it is) can be valuable in cancer treatment on the basis of the
responses in the two patients referenced at the beginning of this
thread.  Since I am most familiar with the young man who had an
extremely rare liver cancer, and whose cancer was essentially
untreatable per the history, his story may or may not have relevance for
 cancer as a whole, nor even for liver cancers as a group.

It is the story of a teenage who was treated under dire
circumstances, first with a drug sorafenib/Nexavar which had been
recently approved in the USA in 12/2005 for adult kidney cancer patients
 who had progression despite earlier failed treatments. The Progression
Free Survival for the responding group was 167 DAYS, with just 2% of
kidney cancer patients having a partial response. Stats from the Phase
III trial in hepatocellular carcinoma (a more common liver cancer)
showed a median TTP (Time to Progression of disease) of 2.8 months.
Sadly, this must have been the most rationale drug to give this boy, and
 required special permission to do so, as it had never been tested in
that age group.

Per the report, he had an initial response, which was remarkable, but
 that was discontinued due to rising liver measures that exceeded the
tolerable levels.  After six months of treatment--nearly twice the
length of time of the median in the trials--there was more tumor growth.
  The boy's health had deteriorated and he was put on a feeding tube.

By this time, requests were made to access 3BP in early 2009, but
before permission came, and with the grim situation, chemo meds were
given, along with other meds.  Concerned with interaction of these meds
with the forthcoming 3BP, chemo was halted, and 3BP began.

This was two treatments in one day, the patient was discharged to go
home, and he seemed to have an appetite.  TWo weeks later, he received
another treatment and went into a coma four days later.  Sent home from
the hospital in the coma, the boy began to recover.

Additional treatments followed, and with some improvement in his
general health, but by the end of year, the boy had died, reportedly
"due an overlaod of liver function."

Case studies are often the basis for designing Phase I trial which
test the safety of the proposed meds.  This case study, despite its
obvious disappointing results, may have value in creating a such a
trial.

Similarly, this case study also reveals that there was a relatively
lengthy response to the use of sorafenib, in a cancer, never previously
treated, and iwth greater duration of response than with the other liver
 cancer types.  This may also lead to a Phase I trial, also valuable.
 One might also ask if the sequence use of sorafenib, followed by the
chemo and then the 3BP was the cause for the extra months he seemed to
have gained.

Beyond that, we need to be cautious about what any of these limited
case report mean to treatment as a whole.  Pretty defensible approach
and protective of patients who with grim prognosis.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Thu Mar 16, 2017 10:05 PM
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Anyone know why  http://www.3bpko.com/ is now open?

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by kccoc on Sat Mar 18, 2017 10:52 AM
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and we stand by the following statemets by Danielus;

1. "Dear Peggy, Let’s not mislead people here, which I see you are constantly doing."

2. " ....every now and then, Peggy was financially
supported by some of the largest Pharma companies of this world. That
tells me there is a conscious  or unconscious bias is her judgement and
statements"

By that, we need to be cautious.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by peggyznd on Sat Mar 18, 2017 12:37 PM
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Please do clarify what you think is misleading as
 to how I have discussed 3BP and its use in the single young liver
cancer patient from the published report. This case study is just that, a
 part of a larger discussion, does not provide any objective proof to
support its use for cancer patients as a whole.  It does not even
describe the exact formulation of 3BP, rather just "speciallly
formulated 3BP (patented and proprietary)".  To point out this basic
lack of information and to explain the range of treatments given to the
young patient is not misleading.

I am concerned that there is too little known about the drug to
promote it as if it were a safe and effective therapy.  That is not
misleading, simply cautious.

I acknowledge openly here and in my other patient advocacy work that I
 have twice a year served on an ethic committee for Roche, along with a
number of academic leaders and internationally prominent human rights
advocates.  In that setting, I advocate for the patient's rights to a
good trial design, respectful treatment and a chance to stay on their
drug, should it be beneficial. In addition, 3-4 times a year I speak to
oncology nurses and some sales staff about my own experience receiving a
 medication, Proleukin (Prometheus Labs) which savedmy life.  For that I
 receive a small check, a flight to the meeting, a stay in an airport
hotel, and the opportunity to tell those nurses what it like to be
desperate for a cure from kidney cancer and melanoma.   Other than that,
 I live on savings and Social Security, glad to be alive to be able to
do so.

I also am a volunteer in a number of patient advocacy groups,
especially centered around kidney cancer education, lobbying for federal
 funds for additional research, or just simply explaining treatment
options.

Do point out to me any particulars of any bias which you see, and we
can discuss it openly.  It is indeed appropriate to be cautious and
clear-headed about any of the meds and therapies which are promoted to
us patients.  We must carefully review the facts, assess them
objectively, and tender warnings when warranted.

Peggyzuckerman@gmail.com

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