Betty Brant

* Alicia Masters - Betty hears of Alicia when covering the FF trial (Fantastic Four #5.5)
* Annihilus - Betty hears of Annihilus when covering the FF trial (Fantastic Four #5.5)
* Big Man - Betty works with him in his cover identity at the Daily Bugle (from Spider-Man #10)
* Blastaar - Betty hears of Blastaar when covering the FF trial (Fantastic Four #5.5)
* Crystal - Betty hears of Crystal when covering the FF trial (Fantastic Four #5.5)
* Daredevil - Betty mentions DD in her reporting (Fantastic Four #5.5)
* Doctor Doom - Betty hears editor Jameson talk about Doom (Spider-Man #5), later she mentions Doom in her reporting (Fantastic Four #5.5)
* Doctor Octopus - *Enemy:* Doc Oc manipulates and attacks Betty many times (since Spider-Man #11), including holding her hostage (An. #1)
* Electro - *Enemy:* Betty warns Peter Parker of seeking out Electro (Spider-Man #9), later Electro kidnaps Betty for Sinister Six (An. #1)
* Flash Thompson - Betty first hears editor Jameson talk about Flash (Spider-Man #5), they randomly meet a number of times (from #15), later her boyfriend at the Daily Bugle
* Galactus - Betty hears of Galactus when covering the FF trial (Fantastic Four #5.5)
* George Stacy - she probably knows the Bugle attacks Stacy on the front page (Spider-Man #60)
* Green Goblin - *Enemy:* Betty first sees Goblin attack the Spider-Man Fan Club (#17), later they meet at the Daily Bugle (e.g. #257)
* Gwen Stacy - they meet at the sendoff party for Flash (Spider-Man #47), and Gwen asks Betty about Peter's whereabouts when he is missing (#115)
* Harry Osborn - they meet at the sendoff party for Flash (Spider-Man #47)
* Hulk - Betty mentions Hulk in her reporting of the FF trial (Fantastic Four #5.5)
* Human Torch - Betty first hears editor Jameson talk about Fantastic Four (Spider-Man #5), and she observes Torch on the street (#21), later covers the trial of Fantastic Four (FaFo #5.5)
* J. Jonah Jameson - her boss at the Daily Bugle (from Spider-Man #4)
* John Jameson - the staff of Daily Bugle had talked of Jameson Jr. (Spider-Man #42), and they meet there (#58)
* Kingpin - *Enemy*: the Daily Bugle puts Kingpin on the front page (Spider-Man #52-53)
* Kraven the Hunter - Betty sees Kraven at the piers and the Bugle office (Spider-Man #15), later Kraven attacks the sendoff party for Flash (#47)
* Liz Allan - they are rivals over the affections of Peter Parker (Spider-Man #13-25)
* Lizard - Betty dicusses Lizard with Peter Parker (Spider-Man #6)
* Magneto - Betty mentions Magneto in her reporting (Fantastic Four #5.5)
* Mary Jane Watson - they meet at Aunt May's house (Spider-Man #25) and the sendoff party for Flash (#47)
* May Reilly - Betty visits Aunt May in hospital with Peter (Spider-Man #9), and they are both held ransom by Sinister Six (An. #1)
* Mole Man - Betty hears of Mole Man as she covers the trial of Fantastic Four (FaFo #5.5)
* Mysterio - Mysterio visits the Bugle offices (Spider-Man #13)
* Ned Leeds - friend and romantic interest (from Spider-Man #19), engaged (#43 to at least 112) and married (unknown exactly when, but in #113 she is named as Betty Leeds)
* Randy Robertson - they meet at the Daily Bugle offices (Spider-Man #67)
* Reed Richards - Betty hears editor Jameson talk about Fantastic Four (Spider-Man #5), later Betty covers their trial (FaFo #5.5)
* Rhino - Rhino is discussed in the Daily Bugle offices (Spider-Man #43)
* Robbie Robertson - co-workers at the Daily Bugle (from Spider-Man #51)
* Sandman - *Enemy:* he kidnaps Betty for Sinister Six (An. #1)
* Scorpion - *Enemy:* Scorpion has made attacks on the Daily Bugle office (Spider-Man #20, 29)
* She-Hulk - Betty covers the trial of Fantastic Four where Jennifer is defense lawyer (FaFo #5.5)
* Silver Surfer - Betty hears of Silver Surfer when covering the FF trial (Fantastic Four #5.5)
* Spider-Man - they meet as they work at the Daily Bugle (from SM#4), where they are once romantically involved (#4-30)
* Sub-Mariner - Betty hears of Sub-Mariner when covering the FF trial (Fantastic Four #5.5)
* Susan Richards - Betty hears editor Jameson talk about Fantastic Four (Spider-Man #5), later Betty covers their trial (FaFo #5.5)
* The Thing - Betty hears editor Jameson talk about Fantastic Four (Spider-Man #5), later Betty covers their trial (FaFo #5.5)
* The Watcher - Betty hears of Uatu when covering the FF trial (Fantastic Four #5.5)
* Valeria Richards - Betty hears of Valeria when covering the FF trial (Fantastic Four #5.5)
* Vulture - *Enemy:* Vulture attacks the Daily Bugle offices (Spider-Man #7), later he and Sinister Six hold Betty hostage (An. Spider-Man #1)