Sibling Team / Video Games

* *Assassin's Creed: Syndicate* has the two playable protagonists, twins Jacob and Evie Frye.
* *Dark Souls III*: Lorian the Elder Prince and Lothric the Younger Prince. Lorian is crippled and mute thanks to the curse borne by Lothric, but he's willing to protect his ill younger brother regardless. Should you defeat Lorian, Lothric will revive him and they will both fight against you.
* ***Super Mario Bros.***: Mario and Luigi, the titular brothers. And their Evil Counterparts Wario and Waluigi, though it's ambiguous if those two are actually brothers.

* *Call of Juarez: Bound in Blood*: The McCall brothers, adventurers and robbers.
* *Vampire: The Masquerade – Bloodlines*: The Chang brothers, guardians of Ankaran Sarcophagus.
* *Arcana Heart*: The Kasuga Family consists of four Miko sisters that fight together with Maori as head.

* ***Crash Bandicoot***: The Komodo Brothers, although they only appeared together in *Crash Bandicoot 2: Cortex Strikes Back* and *Crash Bash*, while Joe went it alone in *Crash Team Racing*. Neither has been seen since.
* *Final Fantasy*:
	+ Palom and Porom are two little twins who team up with Cecil in *Final Fantasy IV*.
	+ The same game introduced the Magus Sisters, a trio of sisters who serve as Barbariccia's minions. They made a few reapearrances in some form in several other games since, most notably as a bonus summon in *Final Fantasy X*.
	+ From *Final Fantasy X*, we have the Summoner Issaru, along with his two younger brothers as his Guardians.
	+ Sisters Faris and Lenna from *Final Fantasy V*.
	+ Edgar and Sabin Figaro from *Final Fantasy VI*. Royal siblings, no less. Having them in the same team together is only mandatory for one very brief period, but their most significant scenes involve both of them. Amusingly, while Sabin can be recruited before Edgar in the World of Ruin, but because he's optional, the (mandatory) scenes for Edgar's recruitment leave him mostly silent. You'd think he'd have some comments about his brother's Paper-Thin Disguise, but no.
	+ *Final Fantasy Dimensions* has two sets of siblings, Diana + Aigis and Alba + Dusk. For most of the game the siblings are separated by the dimensional rift, but they can all potentially be on the same team in the endgame.

* *Double Dragon*: Billy and Jimmy Lee, the Double Dragons.
	+ In the arcade version of *Double Dragon 3*, this trope is invoked literally by having the playable characters divided into four groups of different sibling teams (the Lee Bros., the Oyama Bros., the Urquidez Bros., and the Chin Bros.), essentially an excuse to allow more than one player to control the same character.
	+ Billy and Jimmy's counterpart in *River City Ransom* were named Randy and Andy. Their counterparts in the *Kunio-kun* series were named Ryūichi and Ryūji Hattori.

* *The Great Giana Sisters* features twin sisters, however Giana's twin is missing in one game and is the Damsel in Distress in another. The franchise started out as a Distaff Counterpart PC version of *Super Mario Bros.*.
* The eponymous *Cun-Cun & Santi.*

* ***WarioWare***: The twins Kat and Ana are child ninjas who are always together.

* *Skies of Arcadia*: Jao and Mao, the twin co-leaders of the Tenkou Pirates.
* *Devil May Cry 3*: Dante and Vergil for one glorious moment put aside their differences and subject Big Bad Arkham to the wrong side of a Curb-Stomp Battle. It's implied Dante and Vergil have even done this before as they skillfully switch swords with each other mid-fight. Played straight again in *Devil May Cry 5* as The Stinger shows Dante and Vergil demolishing some demons together in the underworld, albeit in a Enemy Mine situation.

* *Dragon Age II*: Hawke and his or her twin siblings are quite capable in battle, and the surviving twin will always have a class that compliments Hawke's, also making them Sword and Sorcerer.

* *A Super Mario Thing* and its spin-offs have Demo and Iris, the two cycloptic demon sisters and main characters.
* ***Pokémon***:
	+ *Pokémon Ruby and Sapphire* has Tate and Liza, the Brother–Sister Team of Gym Leaders from Mossdeep City.
	+ Some of the trainer classes you can encounter throughout the series are also siblings, like the Twins, Sis and Bro, and the Mysterious Sisters.
* *Disgaea 4: A Promise Unforgotten*: Fuka and Desco, though the former isn't initially happy with the idea of a demon she just met calling her a sister. She does warm up to her and the idea over time, though, and they end up forming a proper team in short time.
* *Telepath Tactics*: Emma and Sabrina Strider, the protagonists, work together to free their father from slavery. There is also the Brother–Sister Team Gavrielle and Farasat Hashmal, who are similarly trying to rescue their enslaved brother.

* Very common in the *Fire Emblem* series:
	+ *Fire Emblem: Shadow Dragon and the Blade of Light*, *Fire Emblem: Mystery of the Emblem*, and their remakes have a few. Both games have the Whitewing sisters Palla, Catria, and Est and the axe fighter brothers Barst, Bord, and Cord, *Shadow Dragon and the Blade of Light* has Lena/Matthis and Minerva/Maria, and *New Mystery* has Minerva/Michalis. Marth/Elice in both games, Lena/Matthis and Minerva/Maria in *Mystery of the Emblem*, and Maria/Michalis in *New Mystery* are downplayed examples since the sisters of each pairing are among the last characters to join the party.
	+ *Fire Emblem Gaiden* has the above-mentioned Palla, Catria, and Est return, while the remake *Echoes: Shadows of Valentia* has Celica fight alongside her long-lost and presumed-dead older brother Conrad.
	+ *Fire Emblem: Genealogy of the Holy War* has Sigurd fight alongside Ethlyn in the first generation, and almost every playable character in the second generation has a playable sibling.
	+ *Fire Emblem: The Binding Blade* has the pegasus siblings Shanna, Thea, and Juno, the armor knight siblings Bors and Gwendolyn, and the Etrurian nobles Klein and Clarine.
	+ *Fire Emblem: The Blazing Blade* has the pegasus siblings Florina, Fiora, and Farina, plus the siblings Priscilla and Raven.
	+ *Fire Emblem: The Sacred Stones* stars the royal siblings of Renais, Eirika and Ephraim (who double subvert this in that they don't spend much time fighting alongside each other until halfway through the game). In addition, the royalty of Frelia, Innes and Tana, fight together, as well as Tethys and her brother Ewan.
	+ *Fire Emblem: Path of Radiance* and *Fire Emblem: Radiant Dawn* both have Ike/Mist, Oscar/Boyd/Rolf, Marcia/Makalov, and Lucia/Geoffrey, while *Radiant Dawn* has Lethe/Lyre and Micaiah/Sanaki (who don't learn about their relationship until the end of the game). Reyson/Rafiel/Leanne is an aversion in that they can never take the battlefield at the same time.
	+ *Fire Emblem Awakening*:
		- Ylissean royalty Chrom can be this with his younger sister Lissa, taking advantage of the same Pair Up mechanic that originated in this game and passed on to *Fates.*
		- Any of the second generation children can form a Paired Up team with their sister Lucina or their sister Morgan, if their father is Chrom or a male Avatar, respectively.note
		- Through SpotPass, Say'ri can team up with one of the Secret Characters, an alternate version of her brother Yen'fay.
	+ *Fire Emblem Fates*:
		- The Polar Opposite Twin ninja Saizo and Kaze can act as this on the *Birthright* and *Revelation* paths with the Pair-Up mechanic, which lets units of the army support and defend one another in battle. But on the *Conquest* path, they have more of a one-sided (on Saizo's part) Cain and Abel, with Saizo enraged over Kaze's defection to their homeland Hoshido's Arch-Enemy Nohr.
		- The members of the Hoshidan royal family (Ryoma, Hinoka, Takumi and Sakura) and the Avatar can act as this with each other on the *Birthright* and *Revelation* paths using the Pair Up mechanic, though it's subverted in the Avatar's case, as he or she is Not Blood Siblings with the Hoshidan royals. Likewise, the Nohrian royal family (Xander, Camilla, Leo, and Elise) can team up (although it's downplayed here; they are paternal half-siblings, and the Avatar is adopted).
		- As in *Awakening*, any of the second-generation children can Pair Up with their brother Kana or their brother Shigure, as long as their mother is a female Avatar or Azura, respectively.note
		- Twin maids Flora and Felicia of *Fates* can Pair Up on the *Conquest* and *Revelation* routes.
	+ *Fire Emblem: Three Houses*, as of Version 1.1.0, Mercedes and Jeritza (also known as the Death Knight) can become one on the Crimson Flower route, as nobles of house Bartels.
	+ *Fire Emblem Heroes* has the twin protagonists Alfonse and Sharena, the royal siblings of Askr.
	+ *Fire Emblem Warriors* has the twin protagonists Rowan and Lianna, the royal siblings of Aytolis.
* The Shitodo siblings (Aoji, Hooaka, and Kuroji) from the *Len'en* series where the first game they appeared as stage bosses and by the fourth game, they become a playable team.
* *Uncharted 4: A Thief's End* sees series protagonist Nathan Drake team up with his long-lost and presumed-dead older brother Sam. One chapter explaining their backstory is even called "The Brothers Drake".
* *A Very Long Rope to the Top of the Sky*: Mint and Ivy are sisters who start out with only each other, fighting monsters, but gain companions on their journey.
* *Chantelise*: Chante and Elise are sisters, on a journey to free Chante from the curse that transformed her into a fairy. It turns out that the witch's curse does this to a pair of sisters every few years, at least, until Chante and Elise stop the Vicious Cycle.