Death

This article is about the conditions that will kill Isaac. For the Death tarot card, see Cards and Runes. For the boss, see Death (Boss).
**Death** occurs when Isaac runs out of health. There are multiple ways to cause this.

* Damage from monsters
* Damage from bosses
* Damage from obstacles
* Damage from bombs
* Damage from a Blood Donation Machine
* Damage from Curse Rooms
* Trading your last bit of health when making a deal with the Devil unless that item provides any hearts in return, such as the
* Using  against Satan
* Using the  card
* ... and more.

As long as Isaac has health of any type (Red, Black, Soul, Bone, Rotten, or Coin hearts) left, they will not be killed, except if Isaac only has an Eternal Heart, though this is impossible.

## Extra Lives

Typically, when Isaac dies, the game over screen appears; however, there are certain revival items, characters, and abilities that can resurrect Isaac after death. It is possible to obtain extra lives throughout a run by picking up various items. When Isaac dies (on most ocasions), they will be revived in the previous room under the new life. Below is a list of these items and special death / extra life conditions that they bestow; take note that reviving as a different character than your current one gives any further Completion Marks to the new one, and the transformation may change stats if the new character has different base values. The order of revives is independent of order of item pickup, determined by the list below from highest to lowest placing:

### Soul of Lazarus

When a  is used, Isaac immediately dies and is revived in the same room at half a heart and given some invincibility time. Alternatively, if Isaac dies while holding the stone, it is automatically used upon taking the fatal hit, acting as another life (still has the same effect as if it was used manually). If used manually, it does not count as taking damage, so any positive or negative effects associated with taking damage are not triggered.

### 1up!

The  grants Isaac an extra life. Upon death of the previous life, Isaac will be revived with full Red Heart containers. If he lacks any, he will revive with one Half Soul Heart. For characters that can't use Red hearts, they will respawn with 3 of their respective heart type (Soul Hearts for  ???,  The Soul,  Tainted ???,  Tainted Soul, and  Tainted Bethany, Black Hearts for  Dark Judas and  Tainted Judas, and Bone Hearts for  The Forgotten).

### Lazarus and Lazarus' Rags

While holding  or playing as  Lazarus, the player will be revived as  Lazarus Risen with 1 Red Heart container. Note that unlike other items, the Rags will revive Isaac on the spot with brief invincibility, as opposed to in the previous room.

### Dead Cat

 grants Isaac nine extra lives. Isaac will be revived with one Red Heart container unless playing as  ??? or  Tainted Judas, where he will be revived with one soul heart/black heart.

### Inner Child

 grants Isaac another life. Upon death, Isaac respawns in the same room with half a heart left, a massive size down, and +0.2 speed. If Isaac has any heart containers, he will respawn with half a heart container filled; otherwise he will respawn with half a soul heart.

### Guppy's Collar

 grants Isaac a 50% chance to be revived with one Red Heart container half-filled. If he lacks any, he will be revived at half a Soul Heart instead. If the collar fails to activate, any other items after Guppy's Collar will be checked. The revives from Guppy's Collar are seeded per death.

### Ankh

The  revives Isaac as ??? with 3 Soul Hearts.

### Broken Ankh

When held,  has a 2/9 chance to resurrect Isaac as ??? with 3 Soul Hearts. The revives from Broken Ankh are seeded per death.

### Judas' Shadow

 revives Isaac as  Dark Judas with 2 Black Hearts.

### Missing Poster

While holding this trinket Isaac will be revived as  The Lost and  will be removed. If already playing as The Lost or  Tainted Lost, Isaac will respawn as normal in the previous room.

## Unlockable Achievements

* The Scissors - **Die** 100 times.

* The Lost -  It's complicated
 Die in a Sacrifice Room while holding .

* Lil Spewer - Have Isaac die to his own explosion from , , or a Horf! pill.