Everything Dies

**Everything Dies** (*すべてが死ぬ, Subete ga shinu*) is an AU in the Glad you Came universe. It takes place during a zombie apocalypse where shinobi and the Akatsuki alike are forced to survive.

## Theme

The theme is a version of Itachi's theme (fan-made by Adaru32) it is both the theme for Itachi and Everything Dies

## Plot

Various viruses plague the world of Naruto and it's up to Naruto along with the Akatsuki to find a cure or die trying their main goal is to survive.

Key

* A character with an "Unknown" status was alive when last seen but was either injured, lost, unsecured, absent, or written out.

## Characters

**A list of characters and their role in Everything Dies**

### Members and Assassins

* Killer B
* Might Guy
* Neji Hyuga
* Rock Lee
* Sai
* Shikamaru Nara
* Shino Aburame
* Shisui Uchiha
* Suigetsu Hozuki
* Temari
* Yamato
* Konohamaru Sarutobi

#### Elders

* Hiashi Hyuga
* Hyuga Elder
* Hiruzen Sarutobi
* Tanaka
* Siashi Haruno
* Reo Haruno
* Izuru Hoshigaki

### Akatsuki Survivors

***Key:*** *Assassins are sent out to kill or mercy kill antagonists or the infected or kill survivors outright this isn't the only time assassins appear as they appear in different AU's with a different purpose in each*

* Nagato - Leader & Assassin
* Obito Uchiha - Assassin
* Itachi Uchiha - Assassin
* Sasori - Assassin
* Deidara - Assassin and Bomber
* Hidan - Assassin
* Josurin Hoshigaki - Assassin, partnered with Kisame Hoshigaki
* Kisame Hoshigaki - Assassin, partnered with Josurin Hoshigaki
* Kakuzu - Assassin
* Madara Uchiha - Assassin
* Zetsu - Assassin
* Airi - Assassin
* Akio - Assassin
* Asaka Uchiha - Assassin
* Ayako - Assassin
* Ayane - Assassin
* Heruko Uchiha - Assassin
* Himari - Assassin
* Hiyori Uchiha - Assassin
* Mayuko - Assassin

### Antagonists / Other Survivors

* Bido
* Dolcetto
* Roa
* Shark Fujishiro Momoshi
* Zabuza Momochi
* Junko Momochi

### Protagonists / Other Survivors

* Tanjiro Kamado - Lone survivor and Assassin
* Ling Yao - Lone survivor and Assassin
* Neteyamu - Lone survivor and Assassin
* Zuko Kamado - Lone survivor and Assassin
* Takaji - Chef

### Suffer the Children

**Suffer the Children** (*子供たちに苦しむ, Kodomo-tachi ni kurushimu*) is an organization of the next generation of Konoha and Kiri's greatest ninja's they are Assassin's in training and are led by Boruto Uzumaki they take in orphans and heal the sick and wounded.

* Boruto Uzumaki
* Haruto Uzumaki
* Asamu
* Ashiru Hoshigaki
* Chojo Akimichi
* Daku Momochi
* Eigon Hoshigaki
* Eiichi
* Genta
* Haruo Uchiha
* Hidemi
* Hikaru
* Himawari Uzumaki
* Hiroji
* Hokuto Uchiha
* Illumi Hoshigaki
* Inojin Yamanaka
* Iruku Hoshigaki
* Jashi
* Jinchi
* Jinkusu Uchiha
* Kagura Karatachi
* Hokuto
* Kaia Hoshigaki
* Kawaki
* Kazuro
* Keji
* Kimio Hyuga
* Mangetsu Hozuki
* Miluki Hoshigaki
* Minoru Uchiha
* Mitsuki
* Naozumi Hoshigaki
* Natsu
* Sakumo Hatake
* Sarada Uchiha
* Satoshi Imamiya
* Arumi Asahina
* Akihiro Yamanaka
* Ame Hoshigaki
* Seishu Hoshigaki
* Shikadai Nara
* Shikanai Nara
* Shiko Aburame
* Shinai Aburame
* Shinki
* Shion Hoshigaki
* Shisua Uchiha
* Shiushi Hoshigaki
* Shizuma Hoshigaki
* Suro
* Takeo Hoshigaki
* Yagura Karatachi
* Yukari Uchiha
* Genju Yakushi
* Hamaru Sarutobi
* Metal Lee
* Iwabee Yuino
* Neteyamou
* Jet Lee

### Other Kiri / Konoha Survivors /Kunoichi

* Airi
* Akio
* Asaka Uchiha
* Asami
* Ayako
* Ayame Hatake
* Ayana Hozuki
* Ayane
* Emiko Yakushi
* Erina
* Hatsue
* Heruko Uchiha
* Himari
* Hiyori Uchiha
* Ichika
* Inoue Yamanaka
* Itsuko Akimichi
* Junko Momochi
* Kana Hyuga
* Kanna
* Mayuko
* Mie Aburame
* Narumi
* Amane
* Mirai Sarutobi

## Diseases / Viruses

Rather than just one virus that plagues the shinobi world, there are multiple some real-world viruses, others inspired by real world viruses

### Yellow Fever

**Yellow Fever** (*黄熱病, Ōnetsubyō*) is a real world mosquito-borne virus The disease originated in Africa and spread to the Americas starting in the 17th century with the European trafficking of enslaved Africans from sub-Saharan Africa. Since the 17th century, several major outbreaks of the disease have occurred in the Americas, Africa, and Europe. In the 18th and 19th centuries, yellow fever was considered one of the most dangerous infectious diseases; numerous epidemics swept through major cities of the US and in other parts of the world.

#### Symptoms

Yellow fever begins after an incubation period of three to six days. Most cases cause only a mild infection with fever, headache, chills, back pain, fatigue, loss of appetite, muscle pain, nausea, and vomiting. In these cases, the infection lasts only three to six days.

But in 15% of cases, people enter a second, toxic phase of the disease characterized by recurring fever, this time accompanied by jaundice due to liver damage, as well as abdominal pain. Bleeding in the mouth, nose, the eyes, and the gastrointestinal tract cause vomit containing blood, hence one of the names in Spanish for yellow fever, *vómito negro* ("black vomit"). There may also be kidney failure, hiccups, and delirium.

### Black Fever

**Black Fever** (黒熱病, Kokunetsubyō) also known as **Kala Azar** (Hindi for "Black sickness) (黒病, Kuro-byō) is real world virus and the most severe form of leishmaniasis and, without proper diagnosis and treatment, is associated with high fatality. Leishmaniasis is a disease caused by protozoan parasites of the genus *Leishmania*.

#### Symptoms

When people develop visceral leishmaniasis, the most typical symptoms are fever and the enlargement of the spleen, with enlargement of the liver sometimes being seen as well. The blackening of the skin that gave the disease its common name in India does not appear in most strains of the disease, and the other symptoms are very easy to mistake for those of malaria. Misdiagnosis is dangerous, as without proper treatment the mortality rate for kala-azar is close to 100%. *L. donovani* itself is not usually the direct cause of death in people with kala-azar, however. Pneumonia, tuberculosis, and dysentery are omnipresent in the immuno-depressed regions where leishmaniasis thrives, and, as with AIDS, it is these opportunistic infections that are more likely to kill, flaring up in a host whose immune system has been weakened by the *L. donovani* infection. Progress of the disease is extremely variable, taking anywhere from one to twenty weeks, but a typical duration for the Sudanese strain of the disease is narrower, between twelve and sixteen weeks.[*citation needed*]

Even with recovery, kala-azar does not always leave its hosts unmarked. Some time after successful treatment—generally a few months with African kala-azar, or as much as several years with the Indian strain—a secondary form of the disease may set in, called post kala-azar dermal leishmaniasis, or PKDL. This condition manifests first as small, measle-like skin lesions on the face, which gradually increase in size and spread over the body. Eventually the lesions may coalesce to form disfiguring, swollen structures resembling leprosy, and occasionally causing blindness if they spread to the eyes. (This disease is not the same as cutaneous leishmaniasis, a milder disease caused by another protozoan of the *Leishmania* genus which also causes skin lesions.)

### Blood Fever

**Blood Fever** (血熱, Chi netsu) is an ancient fictional virus that was responsible for wiping out many villages and humans. It is a seaborne virus known to be found in infected fish

The history of the virus is unknown but what is known is that it wiped a small little known village centuries ago. The virus has an incubation period of 1-2 days before setting in. Moments before the virus enters the hosts they begin coughing which starts mildly akin to that of the common cold before the coughing increases causing paleness of the skin and blue or purple rings around the eyes. Low blood pressure begins to set in which gives the disease it's name. The nose begins to bleed, and the eyes become bloodshot if not treated, the disease can be fatal. Keeping the victim hydrated and well-rested will cure the disease

### Fish Flu

**Fish Flu** (インフルエンザ, *Mana furu*) is an ancient fictional disease that is the main biological antagonist of Everything Dies. It is an ocean-borne virus as well as coming from shark bites. Symptoms during the infection are pale skin, bleeding from eyes, nose, and mouth, fish scale like skin, grey rough skin, cough up blood, seizures, surfaced veins, fainting, death, and reanimation. The virus turns its victims into fish or shark-like hybrids dubbed fish zombies (魚のゾンビ, *mana no zonbi*).

### Bubonic Plague

**Bubonic plague** (腺ペスト, Sen pesuto) is one of three types of plague caused by the bacterium *Yersinia pestis*. One to seven days after exposure to the bacteria, flu-like symptoms develop. These symptoms include fever, headaches, and vomiting, as well as swollen and painful lymph nodes occurring in the area closest to where the bacteria entered the skin. Acral necrosis, the dark discoloration of skin, is another symptom. Occasionally, swollen lymph nodes, known as "buboes", may break open.

After being transmitted via the bite of an infected flea, the *Y. pestis* bacteria become localized in an inflamed lymph node, where they begin to colonize and reproduce. Infected lymph nodes develop hemorrhages, which result in the death of tissue. *Y. pestis* bacilli can resist phagocytosis and even reproduce inside phagocytes and kill them. As the disease progresses, the lymph nodes can hemorrhage and become swollen and necrotic. Bubonic plague can progress to lethal septicemic plague in some cases. The plague is also known to spread to the lungs and become the disease known as the pneumonic plague. Symptoms appear 2–7 days after getting bitten and they include:

* Chills
* General ill feeling (malaise)
* High fever >39 °C (102.2 °F)
* Muscle cramps
* Seizures
* Smooth, painful lymph gland swelling called a bubo, commonly found in the groin, but may occur in the armpits or neck, most often near the site of the initial infection (bite or scratch)
* Pain may occur in the area before the swelling appears
* Gangrene of the extremities such as toes, fingers, lips, and tip of the nose.

The best-known symptom of bubonic plague is one or more infected, enlarged, and painful lymph nodes, known as buboes. Buboes associated with the bubonic plague are commonly found in the armpits, upper femoral, groin, and neck region. Symptoms include heavy breathing, continuous vomiting of blood (hematemesis), aching limbs, coughing, and extreme pain caused by the decay or decomposition of the skin while the person is still alive. Additional symptoms include extreme fatigue, gastrointestinal problems, spleen inflammation, lenticulae (black dots scattered throughout the body), delirium, coma, organ failure, and death. Organ failure is a result of the bacteria infecting organs through the bloodstream. Other forms of the disease include septicemic plague and pneumonic plague in which the bacterium reproduces in the person's blood and lungs respectively.

#### Known Infections

* Unnamed boy (Cured)
* Unnamed boy (Deceased)

### Cocolitztli

The **Cocoliztli Epidemic** or **the Great Pestilence** was an outbreak of a mysterious illness characterized by high fevers and bleeding which caused 5–15 million deaths in New Spain during the 16th century. The Aztec people called it *cocoliztli*, Nahuatl for pestilence. It ravaged the Mexican highlands in epidemic proportions, resulting in the demographic collapse of some Indigenous populations.

Based on the death toll, this outbreak is often referred to as the worst epidemic in the history of Mexico. Subsequent outbreaks continued to baffle both Spanish and native doctors, with little consensus among modern researchers on the pathogenesis. However, recent bacterial genomic studies have suggested that Salmonella, specifically a serotype of *Salmonella enterica* known as Paratyphi C, was at least partially responsible for this initial outbreak. Others believe *cocoliztli* was caused by an indigenous viral hemorrhagic fever, perhaps exacerbated by the worst droughts to affect that region in 500 years and poor living conditions for Indigenous peoples of Mexico following the Spanish conquest (c. 1519).

Although symptomatic descriptions of *cocoliztli* are similar to those of Old World diseases, including measles, yellow fever, and typhus, many researchers recognize it as a separate disease. According to Francisco Hernández de Toledo, a physician who witnessed the outbreak in 1576, symptoms included high fever, severe headache, vertigo, black tongue, dark urine, dysentery, severe abdominal and chest pain, head and neck nodules, neurological disorders, jaundice, and profuse bleeding from the nose, eyes, and mouth. Some also describe spotted skin, gastrointestinal hemorrhaging, leading to bloody diarrhea, and bleeding from the eyes, mouth, and vagina. The onset was rapid and without any precursors that would suggest one was sick. The disease was characterized by an extremely high level of virulence, with death often occurring within a week of the first symptoms, occasionally in as few as 3 or 4 days. Due to the virulence and effectiveness of the disease, recognizing its existence in the archaeological record has been difficult. This is because *cocoliztli*, and other diseases that work rapidly, usually do not leave impacts (lesions) on the decedent’s bones, despite causing significant damage to the gastrointestinal, respiratory, and other bodily systems.

### Typhoid Fever

**Typhoid fever**, also known as **typhoid**, (腸チフス, Chōchifusu) is a disease caused by *Salmonella* serotype Typhi bacteria. Symptoms vary from mild to severe, and usually begin six to 30 days after exposure. Often there is a gradual onset of a high fever over several days. This is commonly accompanied by weakness, abdominal pain, constipation, headaches, and mild vomiting. Some people develop a skin rash with rose colored spots. In severe cases, people may experience confusion. Without treatment, symptoms may last weeks or months. Diarrhea may be severe, but is uncommon. Other people may carry it without being affected, but are still contagious. Typhoid fever is a type of enteric fever, along with paratyphoid fever. *S. enterica* Typhi is believed to infect and replicate only within humans.

Typhoid is caused by the bacterium *Salmonella enterica* subsp. *enterica* serovar Typhi growing in the intestines, Peyer's patches, mesenteric lymph nodes, spleen, liver, gallbladder, bone marrow and blood. Typhoid is spread by eating or drinking food or water contaminated with the feces of an infected person. Risk factors include limited access to clean drinking water and poor sanitation. Those who have not yet been exposed to it and ingest contaminated drinking water or food are most at risk for developing symptoms. Only humans can be infected; there are no known animal reservoirs.

Diagnosis is by culturing and identifying *S. enterica Typhi* from patient samples or detecting an immune response to the pathogen from blood samples. Recently, new advances in large-scale data collection and analysis have allowed researchers to develop better diagnostics, such as detecting changing abundances of small molecules in the blood that may specifically indicate typhoid fever. Diagnostic tools in regions where typhoid is most prevalent are quite limited in their accuracy and specificity, and the time required for a proper diagnosis, the increasing spread of antibiotic resistance, and the cost of testing are also hardships for under-resourced healthcare systems.

A typhoid vaccine can prevent about 40% to 90% of cases during the first two years. The vaccine may have some effect for up to seven years. For those at high risk or people traveling to areas where the disease is common, vaccination is recommended. Other efforts to prevent the disease include providing clean drinking water, good sanitation, and handwashing. Until an infection is confirmed as cleared, the infected person should not prepare food for others. Typhoid is treated with antibiotics such as azithromycin, fluoroquinolones, or third-generation cephalosporins. Resistance to these antibiotics has been developing, which has made treatment more difficult.

In 2015, 12.5 million new typhoid cases were reported. The disease is most common in India. Children are most commonly affected. Typhoid decreased in the developed world in the 1940s as a result of improved sanitation and the use of antibiotics. Every year about 400 cases are reported in the U.S. and an estimated 6,000 people have typhoid. In 2015, it resulted in about 149,000 deaths worldwide – down from 181,000 in 1990. Without treatment, the risk of death may be as high as 20%. With treatment, it is between 1% and 4%.

Typhus is a different disease. Owing to their similar symptoms, they were not recognized as distinct diseases until the 1800s. "Typhoid" means "resembling typhus".

Classically, the progression of untreated typhoid fever has three distinct stages, each lasting about a week. Over the course of these stages, the patient becomes exhausted and emaciated.

* In the first week, the body temperature rises slowly, and fever fluctuations are seen with relative bradycardia (Faget sign), malaise, headache, and cough. A bloody nose (epistaxis) is seen in a quarter of cases, and abdominal pain is also possible. A decrease in the number of circulating white blood cells (leukopenia) occurs with eosinopenia and relative lymphocytosis; blood cultures are positive for *S. enterica* subsp. enterica serovar Typhi. The Widal test is usually negative.
* In the second week, the person is often too tired to get up, with high fever in plateau around 40 °C (104 °F) and bradycardia (sphygmothermic dissociation or Faget sign), classically with a dicrotic pulse wave. Delirium can occur, where the patient is often calm, but sometimes becomes agitated. This delirium has given typhoid the nickname "nervous fever". Rose spots appear on the lower chest and abdomen in around a third of patients. Rhonchi (rattling breathing sounds) are heard in the base of the lungs. The abdomen is distended and painful in the right lower quadrant, where a rumbling sound can be heard. Diarrhea can occur in this stage, but constipation is also common. The spleen and liver are enlarged (hepatosplenomegaly) and tender, and liver transaminases are elevated. The Widal test is strongly positive, with antiO and antiH antibodies. Blood cultures are sometimes still positive.[*citation needed*]
* In the third week of typhoid fever, a number of complications can occur:
	+ The fever is still very high and oscillates very little over 24 hours. Dehydration ensues along with malnutrition, and the patient is delirious. A third of affected people develop a macular rash on the trunk.
	+ Intestinal haemorrhage due to bleeding in congested Peyer's patches occurs; this can be very serious, but is usually not fatal.
	+ Intestinal perforation in the distal ileum is a very serious complication and often fatal. It may occur without alarming symptoms until septicaemia or diffuse peritonitis sets in.
	+ Respiratory diseases such as pneumonia and acute bronchitis
	+ Encephalitis
	+ Neuropsychiatric symptoms (described as "muttering delirium" or "coma vigil"), with picking at bedclothes or imaginary objects.
	+ Metastatic abscesses, cholecystitis, endocarditis, and osteitis.
	+ Low platelet count (thrombocytopenia) is sometimes seen.

#### Known Infections

* Itachi Uchiha (Cured)
* Tanjiro Kamado (Cured)
* Sasuke Uchiha (Cured)

### Typhus

**Typhus**, also known as **typhus fever**, (チフス, Chifusu) is a group of infectious diseases that include epidemic typhus, scrub typhus, and murine typhus. Common symptoms include fever, headache, and a rash. Typically these begin one to two weeks after exposure.

The diseases are caused by specific types of bacterial infection. Epidemic typhus is caused by *Rickettsia prowazekii* spread by body lice, scrub typhus is caused by *Orientia tsutsugamushi* spread by chiggers, and murine typhus is caused by *Rickettsia typhi* spread by fleas.

Vaccines have been developed, but none are commercially available. Prevention is achieved by reducing exposure to the organisms that spread the disease. Treatment is with the antibiotic doxycycline. Epidemic typhus generally occurs in outbreaks when poor sanitary conditions and crowding are present. While once common, it is now rare. Scrub typhus occurs in Southeast Asia, Japan, and northern Australia. Murine typhus occurs in tropical and subtropical areas of the world.

These signs and symptoms refer to epidemic typhus, as it is the most important of the typhus group of diseases.

Signs and symptoms begin with sudden onset of fever and other flu-like symptoms about one to two weeks after being infected. Five to nine days after the symptoms have started, a rash typically begins on the trunk and spreads to the extremities. This rash eventually spreads over most of the body, sparing the face, palms, and soles. Signs of meningoencephalitis begin with the rash and continue into the second or third weeks. Other signs of meningoencephalitis include sensitivity to light (photophobia), altered mental status (delirium), or coma. Untreated cases are often fatal.

### River Blindness

**Onchocerciasis**, also known as **river blindness**, (河川盲目症, Kasen mōmoku-shō) is a disease caused by infection with the parasitic worm *Onchocerca volvulus*. Symptoms include severe itching, bumps under the skin, and blindness. It is the second-most common cause of blindness due to infection, after trachoma.

Adult worms remain in subcutaneous nodules, limiting access to the host's immune system. Microfilariae, in contrast, are able to induce intense inflammatory responses, especially upon their death. *Wolbachia* species have been found to be endosymbionts of *O. volvulus* adults and microfilariae, and are thought to be the driving force behind most of *O. volvulus* morbidity. Dying microfilariae have been recently discovered to release *Wolbachia* surface protein that activates TLR2 and TLR4, triggering innate immune responses and producing the inflammation and its associated morbidity. The severity of illness is directly proportional to the number of infected microfilariae and the power of the resultant inflammatory response.

Skin involvement typically consists of intense itching, swelling, and inflammation. A grading system has been developed to categorize the degree of skin involvement:

* Acute papular onchodermatitis – scattered pruritic papules
* Chronic papular onchodermatitis – larger papules, resulting in hyperpigmentation
* Lichenified onchodermatitis – hyperpigmented papules and plaques, with edema, lymphadenopathy, pruritus and common secondary bacterial infections
* Skin atrophy – loss of elasticity, the skin resembles tissue paper, 'lizard skin' appearance
* Depigmentation – 'leopard skin' appearance, usually on anterior lower leg
* Glaucoma effect – eyes malfunction, begin to see shadows or nothing

Ocular involvement provides the common name associated with onchocerciasis, river blindness, and may involve any part of the eye from conjunctiva and cornea to uvea and posterior segment, including the retina and optic nerve. The microfilariae migrate to the surface of the cornea. Punctate keratitis occurs in the infected area. This clears up as the inflammation subsides. However, if the infection is chronic, sclerosing keratitis can occur, making the affected area become opaque. Over time, the entire cornea may become opaque, thus leading to blindness. Some evidence suggests the effect on the cornea is caused by an immune response to bacteria present in the worms.

The infected person's skin is itchy, with severe rashes permanently damaging patches of skin.

#### Known Infections

* Itachi Uchiha (Cured)
* Sasuke Uchiha (Cured)
* Hayase Uchiha (Cured)
* Naruto Uzumaki (Cured)
* Haruto Uzumaki (Cured)
* Kawaki (Cured)
* Boruto Uzumaki (Cured)

### Ebola

**Ebola**, also known as **Ebola virus disease** (**EVD**) and **Ebola hemorrhagic fever** (**EHF**), (えぼら, Ebora) is a viral hemorrhagic fever in humans and other primates, caused by ebolaviruses. Symptoms typically start anywhere between two days and three weeks after infection. The first symptoms are usually fever, sore throat, muscle pain, and headaches. These are usually followed by vomiting, diarrhoea, rash and decreased liver and kidney function, at which point some people begin to bleed both internally and externally. It kills between 25% and 90% of those infected – about 50% on average. Death is often due to shock from fluid loss, and typically occurs between six and 16 days after the first symptoms appear. Early treatment of symptoms increases the survival rate considerably compared to late start. An Ebola vaccine was approved by the US FDA in December 2019.

The virus spreads through direct contact with body fluids, such as blood from infected humans or other animals, or from contact with items that have recently been contaminated with infected body fluids. There have been no documented cases, either in nature or under laboratory conditions, of spread through the air between humans or other primates. After recovering from Ebola, semen or breast milk may continue to carry the virus for anywhere between several weeks to several months. Fruit bats are believed to be the normal carrier in nature; they are able to spread the virus without being affected by it. The symptoms of Ebola may resemble those of several other diseases, including malaria, cholera, typhoid fever, meningitis and other viral hemorrhagic fevers. Diagnosis is confirmed by testing blood samples for the presence of viral RNA, viral antibodies or the virus itself.

Control of outbreaks requires coordinated medical services and community engagement, including rapid detection, contact tracing of those exposed, quick access to laboratory services, care for those infected, and proper disposal of the dead through cremation or burial. Prevention measures involve wearing proper protective clothing and washing hands when in close proximity to patients and while handling potentially infected bushmeat, as well as thoroughly cooking bushmeat. An Ebola vaccine was approved by the US FDA in December 2019. While there is no approved treatment for Ebola as of 2019, two treatments (atoltivimab/maftivimab/odesivimab and ansuvimab) are associated with improved outcomes. Supportive efforts also improve outcomes. These include oral rehydration therapy (drinking slightly sweetened and salty water) or giving intravenous fluids, and treating symptoms. In October 2020, atoltivimab/maftivimab/odesivimab (Inmazeb) was approved for medical use in the United States to treat the disease caused by *Zaire ebolavirus*.

Ebola was first identified in 1976, in two simultaneous outbreaks, one in Nzara (a town in South Sudan) and the other in Yambuku (the Democratic Republic of the Congo), a village near the Ebola River, for which the disease was named. Ebola outbreaks occur intermittently in tropical regions of sub-Saharan Africa. Between 1976 and 2012, according to the World Health Organization, there were 24 outbreaks of Ebola resulting in a total of 2,387 cases, and 1,590 deaths. The largest Ebola outbreak to date was an epidemic in West Africa from December 2013 to January 2016, with 28,646 cases and 11,323 deaths. On 29 March 2016, it was declared to no longer be an emergency. Other outbreaks in Africa began in the Democratic Republic of the Congo in May 2017, and 2018. In July 2019, the World Health Organization declared the Congo Ebola outbreak a world health emergency.

### Onset

The length of time between exposure to the virus and the development of symptoms (incubation period) is between 2 and 21 days, and usually between 4 and 10 days. However, recent estimates based on mathematical models predict that around 5% of cases may take longer than 21 days to develop.

Symptoms usually begin with a sudden influenza-like stage characterised by fatigue, fever, weakness, decreased appetite, muscular pain, joint pain, headache, and sore throat. The fever is usually higher than 38.3 °C (101 °F). This is often followed by nausea, vomiting, diarrhoea, abdominal pain, and sometimes hiccups. The combination of severe vomiting and diarrhoea often leads to severe dehydration. Next, shortness of breath and chest pain may occur, along with swelling, headaches, and confusion. In about half of the cases, the skin may develop a maculopapular rash, a flat red area covered with small bumps, five to seven days after symptoms begin.

### Bleeding

In some cases, internal and external bleeding may occur. This typically begins five to seven days after the first symptoms. All infected people show some decreased blood clotting. Bleeding from mucous membranes or from sites of needle punctures has been reported in 40–50% of cases. This may cause vomiting blood, coughing up of blood, or blood in stool. Bleeding into the skin may create petechiae, purpura, ecchymoses or haematomas (especially around needle injection sites). Bleeding into the whites of the eyes may also occur. Heavy bleeding is uncommon; if it occurs, it is usually in the gastrointestinal tract. The incidence of bleeding into the gastrointestinal tract was reported to be ~58% in the 2001 outbreak in Gabon, but in the 2014–15 outbreak in the US it was ~18%, possibly due to improved prevention of disseminated intravascular coagulation.

### Recovery or death

Recovery may begin between seven and 14 days after first symptoms. Death, if it occurs, follows typically six to sixteen days from first symptoms and is often due to shock from fluid loss. In general, bleeding often indicates a worse outcome, and blood loss may result in death. People are often in a coma near the end of life.

Those who survive often have ongoing muscular and joint pain, liver inflammation, and decreased hearing, and may have continued tiredness, continued weakness, decreased appetite, and difficulty returning to pre-illness weight. Problems with vision may develop. It is recommended that survivors of EVD wear condoms for at least twelve months after initial infection or until the semen of a male survivor tests negative for Ebola virus on two separate occasions.

Survivors develop antibodies against Ebola that last at least 10 years, but it is unclear whether they are immune to additional infections.

#### Known infections

* Itachi Uchiha (Cured)

**Leptospirosis** (ワイル病, Wairubyō) is a blood infection caused by the bacteria *Leptospira* that can infect humans, dogs, rodents and many other wild and domesticated animals. Signs and symptoms can range from none to mild (headaches, muscle pains, and fevers) to severe (bleeding in the lungs or meningitis). **Weil's disease**, the acute, severe form of leptospirosis, causes the infected individual to become jaundiced (skin and eyes become yellow), develop kidney failure, and bleed. Bleeding from the lungs associated with leptospirosis is known as **severe pulmonary haemorrhage syndrome**.

The symptoms of leptospirosis usually appear one to two weeks after infection, but the incubation period can be as long as a month. The illness is biphasic in a majority of symptomatic cases. Symptoms of the first phase (acute or leptospiremic phase) last five to seven days. In the second phase (immune phase), the symptoms resolve as antibodies against the bacteria are produced. Additional symptoms develop in the second phase. The phases of illness may not be distinct, especially in patients with severe illness. 90% of those infected experience mild symptoms while 10% experience severe leptospirosis.

Leptospiral infection in humans causes a range of symptoms, though some infected persons may have none. The disease begins suddenly with fever accompanied by chills, intense headache, severe muscle aches and abdominal pain. A headache brought on by leptospirosis causes throbbing pain and is characteristically located at the head's bilateral temporal or frontal regions. The person could also have pain behind the eyes and a sensitivity to light. Muscle pain usually involves the calf muscle and the lower back. The most characteristic feature of leptospirosis is the conjunctival suffusion (conjunctivitis without exudate) which is rarely found in other febrile illnesses. Other characteristic findings on the eye include subconjunctival bleeding and jaundice. A rash is rarely found in leptospirosis. When one is found alternative diagnoses such as dengue fever and chikungunya fever should be considered. Dry cough is observed in 20–57% of people with leptospirosis. Thus, this clinical feature can mislead a doctor to diagnose the disease as a respiratory illness. Additionally, gastrointestinal symptoms such as nausea, vomiting, abdominal pain, and diarrhoea frequently occur. Vomiting and diarrhea may contribute to dehydration. The abdominal pain can be due to acalculous cholecystitis or inflammation of the pancreas. Rarely, the lymph nodes, liver, and spleen may be enlarged and palpable.

There will be a resolution of symptoms for one to three days. The immune phase starts after this and can last from four to 30 days and can be anything from brain to kidney complications. The hallmark of the second phase is inflammation of the membranes covering the brain. Signs and symptoms of meningitis include severe headache and neck stiffness. Kidney involvement is associated with reduced or absent urine output.

The classic form of severe leptospirosis, known as Weil's disease, is characterised by liver damage (causing jaundice), kidney failure, and bleeding, which happens in 5–10% of those infected. Lung and brain damage can also occur. For those with signs of inflammation of membranes covering the brain and the brain itself, altered level of consciousness can happen. A variety of neurological problems such as paralysis of half of the body, complete inflammation of a whole horizontal section of spinal cord, and muscle weakness due to immune damage of the nerves supplying the muscles are the complications. Signs of bleeding such as non-traumatic bruises at 1 mm (0.039 in), non-traumatic bruises more than 1 cm (0.39 in), nose bleeding, blackish stools due to bleeding in the stomach, vomiting blood and bleeding from the lungs can also be found. Prolongation of prothrombin time in coagulation testing is associated with severe bleeding manifestation. However, low platelet count is not associated with severe bleeding. Pulmonary haemorrhage is alveolar haemorrhage (bleeding into the alveoli of the lungs) leading to massive coughing up of blood, and causing acute respiratory distress syndrome, where the risk of death is more than 50%. Rarely, inflammation of the heart muscles, inflammation of membranes covering the heart, abnormalities in the heart's natural pacemaker and abnormal heart rhythms may occur.

#### Known infections

* Itachi Uchiha (Cured)
* Sasuke Uchiha (Cured)

### Polio

**Poliomyelitis**, commonly shortened to **polio**, (ポリオ, Porio) is an infectious disease caused by the poliovirus. Approximately 75% of cases are asymptomatic; mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe symptoms develop such as headache, neck stiffness, and paresthesia. These symptoms usually pass within one or two weeks. A less common symptom is permanent paralysis, and possible death in extreme cases. Years after recovery, post-polio syndrome may occur, with a slow development of muscle weakness similar to that which the person had during the initial infection.

Polio occurs naturally only in humans. It is highly infectious, and is spread from person to person either through fecal-oral transmission (e.g. poor hygiene, or by ingestion of food or water contaminated by human feces), or via the oral-oral route. Those who are infected may spread the disease for up to six weeks even if no symptoms are present. The disease may be diagnosed by finding the virus in the feces or detecting antibodies against it in the blood.

Poliomyelitis has existed for thousands of years, with depictions of the disease in ancient art. The disease was first recognized as a distinct condition by the English physician Michael Underwood in 1789, and the virus that causes it was first identified in 1909 by the Austrian immunologist Karl Landsteiner. Major outbreaks started to occur in the late 19th century in Europe and the United States, and in the 20th century, it became one of the most worrying childhood diseases. Following the introduction of polio vaccines in the 1950s polio incidence declined rapidly.

Once infected, there is no specific treatment. The disease can be prevented by the polio vaccine, with multiple doses required for lifelong protection. There are two broad types of polio vaccine; an injected vaccine using inactivated poliovirus and an oral vaccine containing attenuated (weakened) live virus. Through the use of both types of vaccine, incidence of wild polio has decreased from an estimated 350,000 cases in 1988 to 30 confirmed cases in 2022, confined to just three countries. There are rare incidents of disease transmission and/or of paralytic polio associated with the attenuated oral vaccine and for this reason the injected vaccine is preferred.

The term "poliomyelitis" is used to identify the disease caused by any of the three serotypes of poliovirus. Two basic patterns of polio infection are described: a minor illness which does not involve the central nervous system (CNS), sometimes called abortive poliomyelitis, and a major illness involving the CNS, which may be paralytic or nonparalytic. Adults are more likely to develop symptoms, including severe symptoms, than children.

In most people with a normal immune system, a poliovirus infection is asymptomatic. In about 25% of cases, the infection produces minor symptoms which may include sore throat and low fever. These symptoms are temporary and full recovery occurs within one or two weeks.

In about 1 percent of infections the virus can migrate from the gastrointestinal tract into the central nervous system (CNS). Most patients with CNS involvement develop nonparalytic aseptic meningitis, with symptoms of headache, neck, back, abdominal and extremity pain, fever, vomiting, stomach pain, lethargy, and irritability. About one to five in 1000 cases progress to paralytic disease, in which the muscles become weak, floppy and poorly controlled, and, finally, completely paralyzed; this condition is known as acute flaccid paralysis. The weakness most often involves the legs, but may less commonly involve the muscles of the head, neck, and diaphragm. Depending on the site of paralysis, paralytic poliomyelitis is classified as spinal, bulbar, or bulbospinal. In those who develop paralysis, between 2 and 10 percent die as the paralysis affects the breathing muscles.

Encephalitis, an infection of the brain tissue itself, can occur in rare cases, and is usually restricted to infants. It is characterized by confusion, changes in mental status, headaches, fever, and, less commonly, seizures and spastic paralysis.

#### Known infections

* Itachi Uchiha (Cured)
* Sasuke Uchiha (Cured)
* Hidemi (Cured)
* Gaara (Cured)
* Sasori (Cured)

### Dengue Fever

**Dengue fever** (デング熱, Dengunetsu) is a mosquito-borne tropical disease caused by the dengue virus. Symptoms typically begin three to fourteen days after infection. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin itching and skin rash. Recovery generally takes two to seven days. In a small proportion of cases, the disease develops into a more severe **dengue hemorrhagic fever**, resulting in bleeding, low levels of blood platelets and blood plasma leakage, or into **dengue shock syndrome**, where dangerously low blood pressure occurs.

Dengue is spread by several species of female mosquitoes of the *Aedes* genus, principally *Aedes aegypti*. The virus has five serotypes; infection with one type usually gives lifelong immunity to that type, but only short-term immunity to the others. Subsequent infection with a different type increases the risk of severe complications. A number of tests are available to confirm the diagnosis including detecting antibodies to the virus or its RNA.

The characteristic symptoms of dengue are sudden-onset fever, headache (typically located behind the eyes), muscle and joint pains, and a rash. An alternative name for dengue, "breakbone fever", comes from the associated muscle and joint pains. The course of infection is divided into three phases: febrile, critical, and recovery.

The febrile phase involves high fever, potentially over 40 °C (104 °F), and is associated with generalized pain and a headache; this usually lasts two to seven days. Nausea and vomiting may also occur. A rash occurs in 50–80% of those with symptoms in the first or second day of symptoms as flushed skin, or later in the course of illness (days 4–7), as a measles-like rash. A rash described as "islands of white in a sea of red" has also been observed. Some petechiae (small red spots that do not disappear when the skin is pressed, which are caused by broken capillaries) can appear at this point, as may some mild bleeding from the mucous membranes of the mouth and nose. The fever itself is classically biphasic or saddleback in nature, breaking and then returning for one or two days.

In some people, the disease proceeds to a critical phase as fever resolves. During this period, there is leakage of plasma from the blood vessels, typically lasting one to two days. This may result in fluid accumulation in the chest and abdominal cavity as well as depletion of fluid from the circulation and decreased blood supply to vital organs. There may also be organ dysfunction and severe bleeding, typically from the gastrointestinal tract. Shock (dengue shock syndrome) and hemorrhage (dengue hemorrhagic fever) occur in less than 5% of all cases of dengue; however, those who have previously been infected with other serotypes of dengue virus ("secondary infection") are at an increased risk. This critical phase, while rare, occurs relatively more commonly in children and young adults.

The recovery phase occurs next, with resorption of the leaked fluid into the bloodstream. This usually lasts two to three days. The improvement is often striking, and can be accompanied with severe itching and a slow heart rate. Another rash may occur with either a maculopapular or a vasculitic appearance, which is followed by peeling of the skin. During this stage, a fluid overload state may occur; if it affects the brain, it may cause a reduced level of consciousness or seizures. A feeling of fatigue may last for weeks in adults.

## "Seasons"

***\*In the case of the AU, "Seasons" are fan-made episode names for Everything Dies\****

* Torn Apart
* Promises Broken
* Take us Back
* Suffer the Children
* After
* Alone
* Always
* Arrow on the Doorpost
* Lantern
* Remember
* Scars
* Strangers
* Them
* A Good Sailor
* Around Every Corner
* From The Gallows
* No Going Back
* Blood and Lies
* Brave
* Gone
* Weak
* The Raft