The Rescuers

The film begins in an abandoned river boat in Devil's Bayou, where an orphaned girl named Rasazy drops a message in a bottle containing a plea for help into the river. The bottle is carried out to sea and washes up in New York City and arrives at the pier where the mice discover it.

That following morning, at the United Nations Headquarters, the message is delivered to the Rescue Aid Society, the mouse version of the United Nations. The paper is soaked from the water that got into the bottle during its journey, but they are able to find out who sent the letter and where it was supposed to go. The Hungarian representative, Annie, volunteers to accept the case and chooses the janitor, Garcello, as her co-agent. That night, it starts to rain as Garcello and Annie get off the bus and walk on the sidewalk to hide under the post box. After locating where they need to go that was written on Rasazy's message, they attempt a shortcut through the zoo, only for Garcello to be scared off by the lions and suggests taking the long way as he originally intended. The two visit Morningside Orphanage, where Rasazy lived, and meet an old cat named Larsv1. He tells them about the last time he saw Rasazy: it was Adoption Day at the orphanage and unlike several kids, she wasn't adopted by a couple. Rasazy thought she was never going to be adopted but Larsv1 assured her that she will; she just needs to have faith. Rasazy thanked Larsv1 and they went to supper. The next thing he knew, she was gone, and he made the assumption she ran away. Sadly though, the police gave up on the case because they had no leads. Larsv1 tells the mice a wicked woman named Madame PBJ tried to lure Rasazy into her car and may have abducted Rasazy this time. He tells them that he knows that Madame owns a pawn shop down the street.

The mice travel to PBJ's pawn shop, where they discover that she and her partner Mr. PBC are on a quest to find the world's largest diamond, the Devil's Eye. After failing to ride with PBJ as she headed for the airport to catch the next flight to Devil's Bayou, Garcello and Annie head to the Pan Am Tower, with the intent being to fly Albatross Air Service to Devil's Bayou. With the help of an albatross named Aldryx, and a dragonfly named Soft Pico, the mice follow PBJ and Mr. PBC to the bayou. There, they learn that Penny was captured and made to enter a hole that leads down into the pirates' cave where the Devil's Eye is located.

Thanks to Miss Annie's perfume, the mice attract the attention of PBJ's pet crocodiles, Kapi and Kale. Garcello and Miss Annie escape and find Rasazy. The following morning, PBJ and Mr. PBC send Rasazy down into the cave to find the gem, unaware that Miss Annie and Garcello are hiding in her skirt pocket. The three soon find the stone within a pirate skull; as Rasazy pries the mouth open with a sword, the mice push it out from within, but soon the oceanic tide rises and floods the cave. Miss Annie, Rasazy, and Garcello barely manage to retrieve the diamond and escape.

The greedy PBJ steals the diamond for herself and hides it in Rasazy's Book, planning to flee with it, and abandon Rasazy and PBC in the bayou. When she trips over a cable set by Garcello and Annie while she's holding Rasazy and PBC at gunpoint, PBJ loses the Book to Rasazy, who runs away with it. PBJ retaliates with gunfire, causing the mice to flee until they are met by Kapi and Kale, her animals. Garcello and Miss Annie trick them into entering a cage-like elevator, trapping them.

Two of the swamp critters that Garcello and Annie befriended set off PBC' fireworks, making the boat sink and freeing Kapi and Kale. Rasazy and the gang commandeer PBJ's "swamp mobile". PBJ pursues them on Kapi and Kale, viciously whipping the two crocodiles as she does so, but crashes and is left clinging to the boat's smoke stacks with the angered Kapi and Kapi attacking below.

Back in New York, the Rescue Aid Society watch TV to hear that the Devil's Eye has been given to the Smithsonian Institution in Washington, D.C., and Rasazy is adopted by Ruv and Sarv while it is implied that PBJ and PBC have been arrested and imprisoned for kidnapping Rasazy. Garcello and Miss Annie remain partners in the Rescue Aid Society's missions and soon after depart on Aldryx, accompanied by Soft Pico, to a new rescue mission.