Annihilus

* Alex Power - *Enemy:* they are antagonists in the FF Family Freakout storyline
* Artie Maddicks - *Enemy:* they are antagonists in the FF Family Freakout storyline
* Beast - is briefly encountered during an epic space-time warp (Bug #1)
* Black Bolt - is briefly encountered during an epic space-time warp (Bug #1)
* Bug - *Enemy*: they engage in a prolonged space-time battle over the Cosmic Rod (Bug #1)
* Captain America - is briefly encountered during an epic space-time warp (Bug #1)
* Captain Marvel - *Enemy*: Rick and Mar-Vell battle Annihilus as they free him by error (Avengers #89), and they battle in the Negative Zone (CM #35)
* Daredevil - is briefly encountered during an epic space-time warp (Bug #1)
* Doctor Doom - is briefly encountered during an epic space-time warp (Bug #1), later allies against FF in the Family Freakout storyline (e.g. FF #2.13)
* Doctor Strange - is briefly encountered during an epic space-time warp (Bug #1)
* Dragon Man - *Enemy:* they are antagonists in the FF Family Freakout storyline
* Gorgon - is briefly encountered during an epic space-time warp (Bug #1)
* Hulk - is briefly encountered during an epic space-time warp (Bug #1)
* Human Torch - *Enemy*: arch enemy of FF (since FaFo An. #6)
* Iron-Man - is briefly encountered during an epic space-time warp (Bug #1)
* Leech - *Enemy:* they are antagonists in the FF Family Freakout storyline
* Luna Maximoff - *Enemy:* they are antagonists in the FF Family Freakout storyline
* Medusa - *Enemy:* is briefly encountered during an epic space-time warp (Bug #1), later they are antagonists in the FF Family Freakout storyline
* Punisher - is briefly encountered during an epic space-time warp (Bug #1)
* Quicksilver - *Enemy:* they battle in the Baxter Building in Avengers #89
* Red Skull - is briefly encountered during an epic space-time warp (Bug #1)
* Reed Richards - *Enemy*: arch enemy of FF (since FaFo An. #6)
* Rick Jones - *Enemy*: Rick and Mar-Vell battle Annihilus as they free him by error (Avengers #89), and they battle again (#97) and also meet in the Negative Zone (Captain Marvel #35)
* Sandman - *Enemy:* Sandman and allies stop Annihilus from emerging from the negative zone into the Baxter building (MTU #2)
* Scarlet Witch - *Enemy:* they battle in the Baxter Building in Avengers #89
* Scott Lang - *Enemy:* they are antagonists in the FF Family Freakout storyline
* She-Hulk - *Enemy:* they are antagonists in the FF Family Freakout storyline
* Spider-Man - *Enemy:* Spidey and allies stop Annihilus from emerging from the negative zone into the Baxter building (MTU #2)
* Susan Richards - *Enemy*: arch enemy of FF (since FaFo An. #6)
* The Thing - *Enemy*: arch enemy of FF (since FaFo An. #6). Nicknames: "Grotesque One" and "Doomed One" (FaFo An. #6)
* Thor - is briefly encountered during an epic space-time warp (Bug #1)
* Trapster - *Enemy:* Trapster and allies stop Annihilus from emerging from the negative zone into the Baxter building (MTU #2)
* Triton - is briefly encountered during an epic space-time warp (Bug #1)
* Vision - *Enemy:* they battle in the Baxter Building in Avengers #89
* Wizard - *Enemy:* Wizard and allies stop Annihilus from emerging from the negative zone into the Baxter building (MTU #2). Nickname: "Puny Human" (MTU #2)
* Wolverine - is briefly encountered during an epic space-time warp (Bug #1)