Iri-12

**User(s)** | Various

**Iri-12** (アイリ 十二*Airi jū ni*) is an antidote used in a two part treatment that came as one of to greatest fruits of Inari Industries biomedical branch. It has been an used effective treatment against many types of cancers because of it's ability to destroy telomeres and thus destroy cells in a localized area of application. This treatment consists of first being exposed to pure iridosmium and then subsequently being treated with the antidote to the metals toxicity after the cancerous cells are destroyed.

## Toxicity and Symptoms

The handling or exposure of pure iridosmium can have devastating results on the human body. Should it come into contact with the skin, the metal ions will have adverse effects on the molecular structure of the cells. iridosmium ions function as non competitive inhibitors on telomerase enzymes active site within the eukaryotic cell body. This prevents the telomerase from elongating telomeres, or repeating sequence of bases on a chromatid, and thus resulting in an ever shortening strand of DNA during replication. After a few cycles of replication the cells will not be able to replicate, resulting in the premature aging, and eventual dying out of a localized area of cells that were exposed to the metallic ion. Should the ions be able to enter the blood stream, this can have devastating effects on the body's organs and systems.

Onset of symptoms typically arise around a few hours of exposure to Iridosmium; however, direct absorption into the blood stream can speed up this process. These symptoms include localized epithelial necrosis at the site of exposure after 3-4 hours from frequent contact or prolonged exposure. If not treated, epithelial necrosis will progressively worsen until the 8 hour mark, where the telomerase inhibitor begins to affect the myocytes of the human body. Gradually entering into the blood stream, at the 48 hour mark, all cell replication within the body will cease and the mage will be rendered dead.

## Treatment

Iridosmium acts as a non competitive inhibitor, but it's attachment to the enzyme's allosteric site is reversible. When presented with a substance in which iridosmium has a higher affinity for, the weak hydrogen bonds between the enzyme and the inhibitor are released and the iridosmium bonds with the presented substance.

Current research being done by the Inari Family scientist's has yielded a treatment for iridosmium toxicity, and are currently working on a fast acting antidote. From their findings they have triangulated a suitable substance to compete with iridosmium's affinity for telomerase, that substance being hydroxocobalamin (OHCbl). This natural form of Vitamin B12 can be found in a wide variety of animal tissues, with greater concentrations being in the liver and kidneys, as well as a selection of fish. Hydroxocobalamin combines with the iridosmium compound, thus freeing it from the telomerase, and forms iridocobalamin. This compound is water soluble and easily excreted through the urine.

Due to the copious amounts of animal protein that you would be required to eat, should the toxicity progress past the first stage of epithelial necrosis, the Inari's have developed an injectable antidote available for quick use in the field. With a dose of 25 mg/ml, the antidote comes available in 10ml syringes or 20ml syringes, for easy travel and quick use in the field. It is also available as a lyophilize powder that can be combined with a 200ml bag of 0.9% NaCl solution. The current dose is 5g for an average adult given over the course of 20 minutes. With their most common product being the 20ml antidote syringe, this would require 10 intramuscular dose injections (or intravenous for quicker results) for a full treatment. Should the affected mage inject the site quickly after exposure, only one dose to relieve the mages of the effects of iridosmium.

## Cancer Applications

Due to the over replication of cancer cells, the necrotic effects of Iridosmium can be used as a more precise removal of cancerous tissue when compared to the widespread damage done by chemotherapy. This Iri-12 treatment is most effective when used early on in Stage 1 or 2 of cancer treatment. The doctors will usually be able to perform a topical application of iridosmium, and in the controlled conditions of the operating room, be able to administer the Iri-12 antidote before any serious damage is done to regular tissues. Should the cancer be more severe than stage 2, a specialist that is proficient in Blood Magic or Water Magic must be called it to help. This is because an iridosmium solution will be injected into the area in a suspended solution and must be kept within the cancerous area in order to prevent damage to other tissue from the circulation of the Iri-12 solution.

## Trivia

* This is by no means based on anything real and simply a pseudo science approach towards cancer treatment in the realms of magic.