1840s

## 1840

* January 13 – Thomas Williams Thompson born.
* February 16 – Henry Watterson born.
* March 12 – Calvary Morris Young born.
* May 8 – Adolph Moses born.
* May 18 – John Adair died, aged 83.
* August 1 – James Andrew McKenzie born.
* August 11 – Simeon H. Anderson died, aged 38.
* August 11 – Simeon H. Anderson left office as US House of Representatives from Kentucky, 5th District.
* August 22 – John Fowler died, aged 84.
* September 2 – Charles A. Wickliffe left office as Governor of Kentucky.
* September 2 – Robert P. Letcher entered office as 15th Governor of Kentucky.
* September 6 – Gervis D. Grainger born.
* September 12 – John C. Underwood born.
* October 17 – Henry Brainerd McClellan born.
* October 29 – James Franklin Clay born.
* December 1 – Ezekiel Field Clay born.
* December 7 – John Burton Thompson entered office as US House of Representatives from Kentucky, 5th District.
* December 18 – John Colgan born.

## 1841

* February 10 – George W. Snyder died, aged ~60.
* February 21 – Richard Menefee died, aged 31.
* March 4 – Richard Mentor Johnson left office as US Vice President.
* March 4 – John J. Crittenden left office as US Senator from Kentucky.
* March 4 – Sherrod Williams left office as US House of Representatives from Kentucky, 4th District.
* March 4 – William J. Graves left office as US House of Representatives from Kentucky, 8th District.
* March 4 – Richard Hawes left office as US House of Representatives from Kentucky, 10th District.
* March 4 – James T. Morehead entered office as US Senator from Kentucky.
* March 4 – Bryan Owsley entered office as US House of Representatives from Kentucky, 4th District.
* March 4 – James Sprigg entered office as US House of Representatives from Kentucky, 8th District.
* March 4 – Thomas Francis Marshall entered office as US House of Representatives from Kentucky, 10th District.
* May 4 – Patrick H. Pope died, aged 35.
* May 30 – Andrew Anton Schmauch born.
* June 19 – William Morgan Beckner born.
* June 26 – William Johnson Stone born.
* June 30 – John Breckinridge Castleman born.
* July 3 – Humphrey Marshall died, aged ~80.
* July 10 – Henry C. Hines born.
* August 21 – Pierman Powell born.
* September 29 – Andrew J. Cowan born.
* October 8 – John William Green born.
* October 14 – John W. Lewis born.
* December 8 – Turner A. Gill born.
* December 25 – Whiteside Godfrey Hunter born.
* December 30 – Alney McLean died, aged 62.

## 1842

* January 22 – Lot D. Young born.
* January 31 – John L. Murray died, aged 36.
* February 20 – Thomas Speed died, aged 73.
* March 31 – Henry Clay left office as US Senator from Kentucky.
* March 31 – John J. Crittenden entered office as US Senator from Kentucky.
* May 9 – James C.C. Black born.
* May 16 – Francis Johnson died, aged 65.
* June 6 – James Bamford White born.
* June 14 – Henry Atkinson died, aged ~60.
* September 18 – Walter Evans born.
* October 11 – Joseph Holmes Desha died, aged 73.
* November 23 – Chittenden Lyon died, aged 55.
* November 28 – Thomas Edward Pence born.
* November 29 – William H. Holt born.
* December 12 – Edward Young Parsons born.
* December 30 – Lucy Montz born.

## 1843

* January 22 – Albert Shelby Willis born.
* January 23 – Owsley County formed.
* February 21 – Clark L. Hockensmith born.
* March 4 – Philip Triplett left office as US House of Representatives from Kentucky, 2nd District.
* March 4 – Joseph R. Underwood left office as US House of Representatives from Kentucky, 3rd District.
* March 4 – Bryan Owsley left office as US House of Representatives from Kentucky, 4th District.
* March 4 – John Burton Thompson left office as US House of Representatives from Kentucky, 5th District.
* March 4 – Willis Green left office as US House of Representatives from Kentucky, 6th District.
* March 4 – John Pope left office as US House of Representatives from Kentucky, 7th District.
* March 4 – James Sprigg left office as US House of Representatives from Kentucky, 8th District.
* March 4 – John White left office as US House of Representatives from Kentucky, 9th District.
* March 4 – Thomas Francis Marshall left office as US House of Representatives from Kentucky, 10th District.
* March 4 – Landaff Andrews left office as US House of Representatives from Kentucky, 11th District.
* March 4 – Garrett Davis left office as US House of Representatives from Kentucky, 12th District.
* March 4 – William Orlando Butler left office as US House of Representatives from Kentucky, 13th District.
* March 4 – Willis Green entered office as US House of Representatives from Kentucky, 2nd District.
* March 4 – Henry Grider entered office as US House of Representatives from Kentucky, 3rd District.
* March 4 – George Caldwell entered office as US House of Representatives from Kentucky, 4th District.
* March 4 – James W. Stone entered office as US House of Representatives from Kentucky, 5th District.
* March 4 – John White entered office as US House of Representatives from Kentucky, 6th District.
* March 4 – William Thomasson entered office as US House of Representatives from Kentucky, 7th District.
* March 4 – Garrett Davis entered office as US House of Representatives from Kentucky, 8th District.
* March 4 – Richard French entered office as US House of Representatives from Kentucky, 9th District.
* March 4 – John W. Tibbatts entered office as US House of Representatives from Kentucky, 10th District.
* April 1  – Mary Brooks Rathbone died, aged 76.
* April 25 – John McCracken Robinson died, aged 49.
* May 25 – Bennett H. Young born.
* July 13 – John Rowan died, aged 70.
* September 3 – Andrew Jackson Smith born.
* December 7 – George Michael Bedinger died, aged 86.
* December 21 – Thomas S. Pettit born.

## 1844

* January 15 – Joseph Duncan died, aged 49.
* February 7 – Asher Graham Caruth born.
* April 21 – Lottie Deno born.
* April 23 – Hugh McKee born.
* May 6 – Henry B. Mattingly born.
* May 10 – Josiah Dunham died, aged 75.
* May 23 – Edward William Cornelius Humphrey born.
* May 26 – Adolphus Edward Richards born.
* July 31 – John H. Mallory born.
* August 11 – Henry Crist died, aged 79.
* August 25 – Marcellus Jerome Clarke born.
* September 4 – Robert P. Letcher left office as Governor of Kentucky.
* September 4 – William Owsley entered office as 16th Governor of Kentucky.
* October 24 – Polk Laffoon born.
* November 9 – Barton Warren Stone, Sr. died, aged 71.
* November 21 – James Hillary Mulligan born.
* December 10 – Harvey Samuel Irwin born.
* December 26 – William Wright Southgate died, aged 44.

## 1845

* February 5 – Otto Voit born.
* February 12 – Thomas Buford died, aged 60.
* March 4 – Willis Green left office as US House of Representatives from Kentucky, 2nd District.
* March 4 – George Caldwell left office as US House of Representatives from Kentucky, 4th District.
* March 4 – James W. Stone left office as US House of Representatives from Kentucky, 5th District.
* March 4 – John White left office as US House of Representatives from Kentucky, 6th District.
* March 4 – John H. McHenry entered office as US House of Representatives from Kentucky, 2nd District.
* March 4 – Joshua Fry Bell entered office as US House of Representatives from Kentucky, 4th District.
* March 4 – Bryan Rust Young entered office as US House of Representatives from Kentucky, 5th District.
* March 4 – John Preston Martin entered office as US House of Representatives from Kentucky, 6th District.
* March 4 – Andrew Trumbo entered office as US House of Representatives from Kentucky, 9th District.
* March 5 – William P. Thorne born.
* May 8 – Nelly Nichol Marshall born.
* May 17 – Oliver Hazard Perry Anderson died, aged 31.
* July 12 – John Pope died, aged 72.
* July 24 – William Thomas Ellis born.
* August 30 – William O. Boyle born.
* August 30 – Buckner Thruston died, aged 82.
* September 25 – John White died, aged 43.
* October 15 – Philip B. Thompson, Jr. born.

## 1846

* January 27 – Meriwether Lewis Clark, Jr. born.
* January 30 – John Henry Wilson born.
* February 12 – Judson Claudius Clements born.
* March 25 – William Lee D. Ewing died, aged 50.
* June 21 – Isaac McCoy died, aged 62.
* July 27 – William Birch Haldeman born.
* October 13 – Augustus E. Wilson born.
* November 22 – Clifton Rodes Breckinridge born.
* November 25 – Carrie Nation born.
* December 17 – William Thompson Price born.

## 1847

* February 22 – Henry Clay, Jr. died, aged 35.
* February 23 – John J. Hardin died, aged 37.
* February 23 – William Robertson McKee died, aged 38.
* March 3 – William H. Horsfall born.
* March 4 – James T. Morehead left office as US Senator from Kentucky.
* March 4 – John H. McHenry left office as US House of Representatives from Kentucky, 2nd District.
* March 4 – Henry Grider left office as US House of Representatives from Kentucky, 3rd District.
* March 4 – Joshua Fry Bell left office as US House of Representatives from Kentucky, 4th District.
* March 4 – Bryan Rust Young left office as US House of Representatives from Kentucky, 5th District.
* March 4 – John Preston Martin left office as US House of Representatives from Kentucky, 6th District.
* March 4 – William Thomasson left office as US House of Representatives from Kentucky, 7th District.
* March 4 – Garrett Davis left office as US House of Representatives from Kentucky, 8th District.
* March 4 – Andrew Trumbo left office as US House of Representatives from Kentucky, 9th District.
* March 4 – John W. Tibbatts left office as US House of Representatives from Kentucky, 10th District.
* March 4 – Joseph R. Underwood entered office as US Senator from Kentucky.
* March 4 – Beverly L. Clarke entered office as US House of Representatives from Kentucky, 2nd District.
* March 4 – Samuel Peyton entered office as US House of Representatives from Kentucky, 3rd District.
* March 4 – Aylette Buckner entered office as US House of Representatives from Kentucky, 4th District.
* March 4 – John Burton Thompson entered office as US House of Representatives from Kentucky, 5th District.
* March 4 – Green Adams entered office as US House of Representatives from Kentucky, 6th District.
* March 4 – Garnett Duncan entered office as US House of Representatives from Kentucky, 7th District.
* March 4 – Charles S. Morehead entered office as US House of Representatives from Kentucky, 8th District.
* March 4 – John P. Gaines entered office as US House of Representatives from Kentucky, 10th District.
* March 18 – William O'Connell Bradley born.
* August 18 – Alexander Doniphan Pence born.
* October 18 – Jerry Lee born.
* December 8 – Richard Aylett Buckner died, aged 84.

## 1848

* January 26 – Alexander Pope Humphrey born.
* June 12 – John J. Crittenden left office as US Senator of Kentucky.
* June 23 – Thomas Metcalfe entered office as US Senator from Kentucky.
* September 6 – William Owsley left office as Governor of Kentucky.
* September 6 – John J. Crittenden entered office as 17th Governor of Kentucky.
* September 9 – Thomas A. Robertson born.
* September 21 – Columbus P. Chastain born.
* September 27 – William J. Graves died, aged ~43.
* October 9 – Frank Duveneck born.
* November 4 – Isaac Wolfe Bernheim born.
* November 7 – James Taylor died, aged 79.
* December 1 – Evan Evans Settle born.
* December 31 – E. Belle Mitchell born.

## 1849

* January 11 – John Croghan died, aged 58.
* January 16 – John Daugherty White born.
* January 31 – Isaac Herschel Goodnight born.
* January 31 – Rachel Beasley Ray born.
* February 9 – Laura Clay born.
* February 27 – Addison Davis James born.
* March 4 – Thomas Metcalfe left office as US Senator from Kentucky.
* March 4 – Beverly L. Clark left office as US House of Representatives from Kentucky, 2nd District.
* March 4 – Samuel Peyton left office as US House of Representatives from Kentucky, 3rd District.
* March 4 – Aylette Buckner left office as US House of Representatives from Kentucky, 4th District.
* March 4 – Green Adams left office as US House of Representatives from Kentucky, 6th District.
* March 4 – Garnett Duncan left office as US House of Representatives from Kentucky, 7th District.
* March 4 – Richard French left office as US House of Representatives from Kentucky, 9th District.
* March 4 – John P. Gaines left office as US House of Representatives from Kentucky, 10th District.
* March 4 – Henry Clay entered office as US Senator from Kentucky.
* March 4 – James Leeper Johnson entered office as US House of Representatives from Kentucky, 2nd District.
* March 4 – Finis McLean entered office as US House of Representatives from Kentucky, 3rd District.
* March 4 – George Caldwell entered office as US House of Representatives from Kentucky, 4th District.
* March 4 – Daniel Breck entered office as US House of Representatives from Kentucky, 6th District.
* March 4 – Humphrey Marshall entered office as US House of Representatives from Kentucky, 7th District.
* March 4 – John C. Mason entered office as US House of Representatives from Kentucky, 9th District.
* March 4 – Richard H. Stanton entered office as US House of Representatives from Kentucky, 10th District.
* March 12 – Robert B. McAfee died, aged 65.
* March 14 – Albert Gallatin Hawes died, aged 44.
* March 28 – William Richardson Belknap born.
* May 6 – James D. Breckinridge died, aged ~68.
* June 30 – William Joseph Deboe born.
* June 30 – Elisha I. Winter died, aged 67.
* September 24 – James D. Black born.
* October 10 – John Kerr Hendrick born.
* October 17 – William Claiborne Owens born.
* October 28 – Nancy Huston Banks born.
* December 21 – James Lane Allen born.
* December 24 – George Gilmore Gilbert born.
* December 26 – William Wright Southgate died, aged 49.