Box of Friends

**Box of Friends** is an unlockable activated item added in *The Binding of Isaac: Afterbirth*.

## Effect

* Upon use, it adds one copy of each of Isaac's familiars for the duration of the current room.
* If Isaac has no familiars, a  will spawn for the duration of the current room.

## Notes

* Lilith starts with this item by default, even if it hasn't been unlocked yet.
* If Isaac has more than one copy of the same familiar, it will still only add one copy.
* Blue Flies, Blue Spiders, and orbitals (, , etc) are not copied.
	+ It now copies some orbitals.
* Many familiars can be spawned in Greed mode and Boss Rush, as completing waves charges the item.
* Familiars with the `uniquefamiliar` item tag are ignored by Box of Friends. If Isaac has only unique familiars, a Demon Baby is spawned.
* The item will cost 10 cents if found in a Shop

## Synergies

* /  / : Upgrades the cube/ball for the current room. This can be used to easily unlock the Super Meat Boy and Bandage Girl achievements.
	+ Cubes of Meat from  cannot be duplicated or upgraded.
* : Tames an angry Blood Puppy and spawns another temporary one.
* : When used upon entering a room, Box of Friends eliminates the item delay, which allows Isaac to launch Bob's Brain immediately.
* : Spawns black wisps on the middle ring. After creating a wisp, Box of Friends also gives temporary copies of all of Isaac's wisps, including any extra copies Box of Friends made.
* : Adds two copies of each familiar.
* : All around useful, can charge box of friends mid room to spawn more of itself creating a charging loop.
* : Familiar will be copied.
* : Creates additional Incubus familiars, which share the same tear modifiers as the player.
* : Will copy Lil Dumpy, adding an extra charge to Lil Dumpy's -like protection.
	+ This process can be repeated to make Isaac near-invincible.
* : Very useful on Greed mode, as using it will add an attacking fly, killing enemies and bosses very quickly.
* : Creates additional Twisted Pairs with the same tear modifiers as the player. Multiple twisted pairs will line up horizontally, covering a broader area.

## Interactions

* /  /  /  / : These familiars are not copied.
* / : Familiars are multiplied but do not give Isaac additional lives.
	+ : No longer copies the familiar either.
* : Flies gained from Abyss do not count as familiars for Box of Friends, and are not copied.
* : If used before taking damage, the white fly will circle Isaac. However, multiple white flies cannot be spawned, so using Box of Friends after taking damage or using it multiple times in a room creates no effect.
* : Creates another randomly generated familiar, rather than copying the same one.
* : Will spawn a level 1 Bumbo regardless of the original Bumbo's current level.
* : Duplicates the Head circling Isaac's body. Only one head will shoot tears.
	+ Considers the second head as an extra copy, granting Isaac a temporary stat boost for the room
* : All poop familiars turn into white poop at the same time, and their effects are accumulative. A new poop familiar appears even if the previous poops have been used up.
* / : Not copied. They will not spawn a  if no other valid familiars are found, unlike other familiars that aren't copied.
* / : Key pieces are multiplied, but do not complete the other half.
	+ Key pieces are not copied.
* / : Knife pieces and the knife are not copied.
* : Creates a random spewer rather than copying the current one.
* : Cannot be duplicated.
* : The familiar itself doesn't appear, but instead, it decreases tear delay by 2 (effective tears up) when used, without needing to take damage.
	+ No extra tear delay is granted, neither before or after breaking.
* : Familiars spawned by Monster Manual are not copied. It will still spawn a  if a familiar from Monster Manual is generated and there are no other valid familiars that can be duplicated.
* : Each copy of Multidimensional Baby follows the previous copy with a 2-second ( 0.66-second) delay. Tears shot through multiple babies will only be duplicated once.
* Pickup generation familiars: The copied familiars will drop pickups independently.
* : Existing Quints familiars will not be duplicated, nor more will be created. If Isaac has no other familiars, the generated Demon Baby will hover with the Quints instead of following Isaac.
* : A new follower Shade spawns even if Isaac has already absorbed the original.
* : The Seraphim familiar is not copied.

## Trivia

* The Box of Friends seems to resemble the Lament Configuration of the Lemarchand's box from Clive Barker's *Hellraiser*.
* This item used to have a recharge time of 2, until an update on November 4, 2015.
	+ When playing in Korean, this item still has a recharge time of 2.
* In the game files this item's sprite is called "Pandora's Box" by mistake.