Complete Monster/The X-Files

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*The X-Files* was a nine-season Long Runner, and monsters were the show's thing. Some of these were genetic mutants who acted on predatory instincts and followed their biological needs. However, several of them crossed into the Complete Monster territory. Often these cases were surprisingly light on the paranormal stuff, making them fairly mundane and all the more frightening.

* The Cigarette Smoking Man, also known as the Cancer Man, is supposed to be a Knight Templar, but he veers into Complete Monster territory on several occasions. He is Agent Mulder and Agent Scully's main antagonist, *the* villain of the Myth Arc, and the only Complete Monster who's not a Monster of the Week. He's associated with the grand government conspiracy Mulder and Scully are trying to uncover, and while he had numerous means to neutralize his opponents, he often chose especially cruel ways. Trying to *burn Mulder alive* after Mulder finds the mass grave where the CSM and his associates threw the bodies of aliens that had been vaccinated and experimented-upon to death is just one example of the crimes he's committed in the name of his self-serving agenda. He also had his ex-wife and mother of his son turned into an alien-human hybrid. He attempted to *murder his own son in cold blood*; said son survived, and CSM had him experimented on in unspeakable ways. He has saved the Agents' lives a couple of times, or at least he didn't interfere with their attempts of saving each other, but he admitted he did this only because it's satisfying to see them live on and get their spirits crushed. Even when claiming to want to "atone", he still shows no real regret for his actions and gives every indication that he'll be back up to his old tricks once he's achieved the results he currently desires. Clearly, he is a sociopathic zealot to the very end.
* Cecil L'Ively from "Fire" in the first season is one of the Complete Monsters that actually belong among the paranormal beings. He's a pyromaniac who can ignite things with his mind and who himself cannot be hurt by fire at all. He's a creepy stalker and pursues women in powerful positions, burning their husbands and other family members, including children, to death. He genuinely enjoys torturing people and shows no remorse for any of this deplorable behavior.
* Donald Pfaster from "Irresistible" and "Orison" is a necrophiliac who collects hair and fingers of his female victims after he's done with them. His fetish escalates into becoming a Serial Killer. He has some kind of twisted, sick affection for his victims which is utterly scary. He's a horribly menacing killer who shows no regrets for his deeds, looking surprised when he's caught. As if it was his right to treat people as he pleases.
* Phyllis Paddock from season 2's "Die Hand Die Verletzt" is a fake substitute teacher who may or may not be the demon Azazel. Her first onscreen appearance (albeit not fully seen) involves her lifting a teenage boy into the air by his neck before brutally murdering him, tearing out his eyes and ripping out his heart, all because he was unfortunate enough to have accidentally summoned her. Later, she caused the death of a young girl by taking control of her and forcing her to slit her own wrists, only because she was the stepdaughter of the leader of a coven whose belief in the demon had lapsed. She then caused said leader to be gruesomely devoured by a snake familiar, and the other three members of the coven to kill themselves. The only reason for her murders was that the coven had become lax in the practice of their religion, and had stopped providing Azazel with sacrifices.
* Colonel Wharton who appeared in "Fresh Bones". He's a sociopath that tortures people from Haiti who are held at an immigrant camp he's in charge of. It's revealed that he's responsible for several deaths: a small boy, a Haitian prisoner who knew voodoo and several of his soldiers that tried to stop him. He thought it's good to kill emigrants, better than sending them back home.
* Dr. Jack Franklyn from "Sanguinarium" is a demonic doctor and a narcissistic warlock who makes human sacrifices by taking over the minds of various surgeons and having them kill patients in horrific ways (draining a patient's blood via liposuction, nearly cutting a patient's head off with a laser, and melting a patient's face off) so that he can retain his youth and looks. Oh, and he escapes in the end without facing any consequences, and finds another hospital where he can do the exact same thing.
* John Lee Roche from "Paper Hearts" is an utterly evil child molester and Serial Killer who killed 16 little girls. He manipulated their parents to trust him, and then came back and kidnapped the girls at night. He plays sick mind games with Agent Mulder and tries to convince him that he took his little sister Samantha (whose disappearance was not explained), even though it's not true. He manages to escape from prison during the re-opened investigation and tries to take another girl. When Mulder catches them, he nearly shoots her. He doesn't regret his deeds at all and would continue if he only could.
* Darryl Weaver in "Brand X" is a blackmailer and murderer, who, upon realizing he's relatively immune to toxic cigarettes that infest the bodies of those who inhale the smoke with insects that eat their insides apart until they kill the victim, proceeds to blackmail the man at the tobacco company who produced them into giving him more and more, using them to kill anyone who starts to realize the weapon they created, and even attempts to murder Mulder in the same fashion. When he's finally cornered by Skinner, he rants about he's a special breed of human and threatens to light one up to kill him, and even as Skinner shoots him and snuffs out his cigarettes, he dies unrepentant of any of his crimes.