Hypercoagulation

**Hypercoagulation** is an unlockable passive item added in *The Binding of Isaac: Repentance*.

## Effects

* After Isaac takes damage from an enemy or donates health, he drops a Red Heart that despawns after 1.5 seconds.
	+ The heart dropped depends on the source: half-hearts of damage taken drop Half Red Hearts, and full hearts of damage taken drop full hearts.
	+ The hearts will get launched out of Isaac with momentum, making them difficult to pick up.
	+ If Isaac is firing tears as he gets hit, the heart will get launched in that direction.

## Notes

* Damage sources that scale up from half a heart of damage to a full heart of damage starting on Womb/Corpse will still only cause Hypercoagulation to spawn half a heart. However, being hit by a champion enemy will still spawn a full red heart, even though all enemies do a full heart of damage by that stage.
* Red hearts are not spawned when Isaac loses heart containers (such as through health down pills, buying Devil Room items, using , etc), with the only exception being .
* Red hearts will still drop regardless of the type of heart being subtracted from damage, making the item generally useless for characters who cannot utilize red hearts.
* The following damage sources will activate Hypercoagulation:
	+ Enemy attacks
	+ Normal spikes
	+ Spiked rocks
	+ Fire Places
	+ Explosions
	+ Blood Donation Machines
	+ Devil Beggars
	+ Confessionals
	+ Hell Games
	+ (despite it not taking health)
	+ Extra damage taken from holding
* The following damage sources will not activate Hypercoagulation:
	+ Curse Room doors
	+ The door to Mausoleum
	+ Sacrifice Room spikes
	+ Spiked Chests/ Mimic Chests
	+ Bad Trip pills
	+ Golden Battery
	+ shop spikes

## Interactions

* Ace Cards /  /  / : Converted/duplicated hearts will not disappear.
* : The temporary heart will be converted into a Blue Fly/Spider.
* : By intentionally taking damage with something like a fire and grabbing the half-red hearts, Isaac can easily generate powerful familiars for free.
* / : Rerolled hearts will still disappear.
* : Spawns two more full red hearts when Glass Cannon breaks, regardless of how much health was lost to it.
* Keeper /  Tainted Keeper: Spawns blue flies upon getting hit, essentially granting them the same effect as .
* : The heart will not be converted to coins.
* : Doesn't spawn hearts.
* : Hearts spawned do not turn into keys but simply do not spawn 80% of the time, and the 20% that do spawn will always be Black Hearts.

## Synergies

* / : Damage taken to use the item also spawns hearts, reducing the cost of using them. The first usage of these items each room will spawn a full red heart.
* / Percs! pill / : Damage sources that spawn full red hearts will still spawn a full red heart despite the cost being reduced to half a heart.
* / : The hearts will count toward gaining stat boosts/familiars.
* : Can be used to spawn full red hearts for Isaac to pick up. Ideally, this should be done in a confined space so Isaac can easily pick up the heart.
* : As long as Equality is active, all hearts spawned will be doubled and never disappear. Hearts remain on the ground even after the effect is no longer active.
* : Doubles the healing received from the hearts spawned.
* / : Will immediately start pulling the dropped hearts to Isaac, breaking their momentum and making collection much easier.

## Trivia

* Hypercoagulation (otherwise known as Thrombophilia) is a medical condition that causes blood clots to spontaneously form in a person’s blood vessels and prevents them from dissolving properly.