NG+3R Guide

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> | NG+3
> | Post-Eternity
> | Quantum
> | Ghostify
> | Upcoming
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> This is the guide for the Alpha version of NG+3 Respecced. It can be found here.
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> For NG+3 v2.301, go here.
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> Other useful resources include the game's Discord server and the wiki bug tracker.[1]
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# NOTE: Significant balancing changes to Time Dilation in the v0.71 Alpha have made this entire Guide inaccurate. Do not use until this has been updated.

***Note: because this Guide is WIP, it will undergo changes on a somewhat frequent basis in line with the pace of the development of NG+3R, so week to week, day to day, or even hour to hour, progression as denoted in this Guide may drastically change. Only play the Alpha Test Server on a save you don't want to risk being broken, and if you're testing the development changes, make sure to check with the developers on what point to start testing from for a particular iteration of the beta. The current iteration of the Guide is outdated and will be rewritten over the next several weeks, and the goal for the first draft is to contain progression up to Beta v0.5 (Paired Challenges).***

The original game, for those who have not played it prior to visiting this page, can be found here. For players coming to NG+3R from NG+2, and for those who have played the main game but do not wish to do so again, import your save from either of those into NG+3R and you'll be good to go. NOTE: console commands and the 'Infinite' bug are fatal if imported and will result in your game being unplayable. Until these bugs are fixed, the only way to play NG+3R if you are experiencing this issue is to start a clean save and to not utilize console commands.

Time Study setups for each area of the game will be provided at the end of each sub-section in a bullet/number list for easier usage, where applicable. All setups are exported directly from the game at each stage, and can be easily imported when needed. **Note: Mastery Studies and the Study tree format have changed, and trees with Mastery Studies cannot be imported from release saves into NG+3R. The new trees will be published, as applicable, in place of the old ones. In order to view the full Time Study Setups, you must Expand this page using the button next to the left sidebar on this page.**

Exponential clarification for later in the game:

1. e is the base exponential notation. For example e1,000,000,000,000,000.
2. ee is the condensed form of this. For example, e1,000,000,000,000,000 would, in this case, be ee15, and in another example, e10,000,000 would be ee7.
3. e1e(x) means the amount in the condensed notation is being clarified. For example, e20,000 would be e2e4, and e5,000,000,000 would be e5e9. After e9.999e11, the game automatically condenses the notation to whatever your 'on exponents' setting is.
4. [redacted]

## Eternity Era

### Terminology

This is a list of all abbreviations for values you'll encounter at this stage of the game and further, and what each means. A similar section will be present for each major stage of the game.

### Time Dilation: 1e6 - 1e16 DT

This is the beginning of NG+3, as a new upgrade in the Dilation menu will be available (starts at 1e6 DT and increases logarithmically until 1e44, then by e4 until 1e100 DT) that will speed up your progress drastically. The upgrade, which adds 0.25 to the exponent of the Tachyon Particles (TP) gain formula for dilated runs, greatly improves your TP gain (generally one OoM - or 10x - per upgrade).

Once you've reached at least e14 DT, you'll be able to purchase a new upgrade: "Dilated time makes replicate interval increase slower" for 1e14 DT. This upgrade significantly reduces the interval for replicanti growth over 1.79e308, allowing you to gain replicanti much faster, and this decrease becomes greater at higher DT. By the time you have this upgrade, you should have ~400+ normal RGs. Note after 400 RGs, max RG cost begins scaling MUCH faster.

Once you've reached at least e16 DT, you'll be able to purchase a new upgrade: "Eternities and dilated time power up each other" for 1e16 DT. This upgrade allows you to gain more Eternitied stat and DT based on one another, and makes grinding for eternities viable again (the last time you had to do this was to max out TS193's bonus), though don't worry about doing so for now. Around this time, it's time to finally unlock Eternity Upgrade 7 for 1e3,000 EP, which lets you get all TS23x studies.

Time Study setups for this stage:

1. 11,21,22,31,32,33,41,42,51,61,62,72,71,73,82,81,83,92,91,93,102,103,101,111,123,133,143,151,161,162,171,181,192,191,193,212,211,213,214,222,223,232,226,233,227|0 - Prioritizes TP gain during dilated runs prior to the 1e14 DT upgrade.
2. 11,21,22,31,32,33,41,42,51,61,62,72,71,73,82,81,83,92,91,93,102,103,101,111,123,133,143,151,161,162,171,181,192,191,193,212,211,213,214,222,223,232,225,233,227|0 - Prioritizes TP gain during dilated runs after the 1e14 DT upgrade.
3. 11,21,22,32,31,33,41,42,51,61,62,73,71,81,72,82,83,93,92,91,101,102,103,111,121,131,141,151,161,162,171,181,191,192,193,214,213,212,211,222,224,225,227,234,232|0 - Prioritizes EP gain when not in dilated runs.

### Time Dilation: 1e16 - 1e35 DT

At this point, you'll enter a moderate grinding stage, where you'll alternate between doing EP and TP runs for progression. When you do an EP run, make sure to max your EP mult upgrade and buy your TDs. When buying DT upgrades, make sure to follow this order:

1. TP formula increase - This provides the most immediate benefit in dilated runs because of the ~10x TP boost.
2. 3x TP gain - Same reason as above, though this is a fixed value instead of a scaling increase.
3. TG threshold mult decrease - unlike in NG+3.1, this upgrade no longer resets anything, AND no longer has a limit at e124 DT, so it's worth it to get this before your 2x DT upgrade for the boost it provides to your AM production.
4. 2x DT gain - This will make getting the other upgrades easier.

Make sure to do a run for TP about each time you get a 3x or formula upgrade, as this will provide quick, short-term boosts to your DT gain that will let you alternate to the next upgrade.

Continue pushing in this manner until you reach about e38-40 DT. Eventually, you'll be able to purchase the TT upgrade "Unlock Meta Dimensions" for 1e20 TT. By the end of this section, you should have at least around 1e39-1e40 DT, 1e20 TT, and something around e1.2-1.4B antimatter and e11,000-e13,000 EP.

Time Study setups do not change for this stage.

### Meta Dimensions: 1e35 - 1e60 DT

Once you've reached 1e20 TT, you'll be able to unlock Meta Dimensions. Upon unlocking MDs, you'll notice a couple similarities and a couple differences to that of ADs. MDs and ADs are similar in that there are eight MDs, with the same cost scaling as ADs, and that you need to Shift/Boost with the same initial cost in order to unlock MD5-8 and power them up. However, there are some key differences. MDs do not have tickspeed upgrades or Galaxies; these are traded off in favor of the boost that your best-ever MA provides to ADs, which is x8. In addition, you'll notice, where Galaxies should be, an unlock called Quantum. This will become important for the next major stage of progression, but don't worry about it for now. Finally, DT also improves MDs using the formula DT0.1/1e4. Also, if you go into the Dilation upgrades screen, you'll now see a new row of upgrades based around MA and MD. Also, you unlock the Achievement "I'm so meta", which locks TS121's multiplier to 50x and increases TS122's multiplier from 35x to 50x.

Now that you've unlocked MDs, your goal is to push your MA as high as you can while also alternating between EP and TP runs. Dilated runs are still important at this stage because of the boost DT provides to MDs, so you should be focusing on getting your DT gain up.

Once you've reached at least e50 DT and ~5 MDBs, you'll be able to purchase a new upgrade: "Meta Dimensions gain a multiplier based on tickspeed" for 1e50 DT. With this upgrade, buying tickspeed upgrades slightly boosts MDs and MA production (right now, it should be ~9x), and this will boost you to around MDB 6-7.

Time Study setups do not change for this stage.

### Meta Dimensions: 1e60 - 1e100 DT

Once you've reached e60 DT, you'll be able to purchase a new upgrade: "Meta dimension boosts, shifts, and per-ten upgrades are boosted by dilated time" for 1e60 DT. This is a massive upgrade, and should instantly push you to MDB 9-10, and easily allow you to get MDB 11 and possibly 12. After buying this upgrade, you will almost immediately auto-unlock the achievement "GAS GAS GAS", which provides QoL (quality of life) in the form of the EP mult and TD autobuyers. Make sure to turn these on! You will now not need to go to the TD or EP upgrades screen until after Quantum. Also, you'll have passed ee5 EP and ee10 AM at this point.

Once you've reached e80 DT, you'll be able to purchase a new upgrade: "The meta-antimatter effect on dimension boosts is stronger" for 1e80 DT. This powers up the best-ever MA effect on DimBoosts from x8 to x9, and provides a huge boost to EP gain. Once you've purchased this upgrade, it's finally time to grind Eternities again. Your goal will be to hit 1e12, or 1 trillion, Eternities, to unlock the achievement "The cap is a million, not a trillion", which improves the formula for Eternity Upgrade 2 and Time Study 231. At 1e80 DT, it takes less than a minute to get this achievement. Getting this will also automatically unlock slow Meta Dimension autobuyers (tied to the 1 T eternity milestone); they are very slow, but they're better than nothing. (NOTE: You still need to get MDB's manually!)

Once you've reached e100 DT, you'll be able to purchase a new upgrade: "Dilated time production is boosted based on best ever meta-antimatter" for 1e100 DT. This upgrade boosts your DT production based on how high you've pushed your MA, and also unlocks Mastery Studies, which we'll go over momentarily.

By the end of this section, you should have at least 1e100 DT, all row 14 achievements, 15 MDBs, and around e530k (e5.3e5) EP.

Time Study setups for this stage:

1. 11,21,22,32,31,33,41,42,51,61,62,73,72,71,81,82,83,93,91,92,101,102,103,111,121,131,141,151,161,162,171,181,191,192,193,211,212,213,214,222,224,225,228,232,234|0 - Prioritizes EP gain when not dilated after obtaining the 1e60 DT upgrade.
2. 11,21,22,32,31,33,41,42,51,61,62,73,72,71,81,82,83,93,91,92,101,102,103,111,121,131,141,151,161,162,171,181,191,192,193,211,212,213,214,222,223,225,228,232,234|0 - Prioritizes TP gain when dilated after obtaining the 1e60 DT upgrade.

### Mastery Studies: 1e69 TT - 2.08e385 MA

After buying the 1e100 DT upgrade, Mastery Studies will appear as a tab in the Eternity section, and a portal button appears at the bottom of the Time Studies tab. Mastery Studies contain ten studies and Eternity Challenges 13 and 14. Right now, the studies cost too much TT for you to afford, so focus on improving your DT and TP gain in the same way as you've been doing up to this point, which itself will become more difficult, as the TP formula and TP gain upgrades now have cost scaling applied, which makes them more difficult to get. The TT generator upgrade also softcaps, meaning that getting more TP will contribute less and less to TT gain.

Mastery Studies differ from Time Studies in two ways: first, Mastery Studies, when bought, increase the cost of the studies around them by a multiplier which can be viewed in the tab by holding Shift. If the multiplier is less than 1x or says "reset", the cost is being divided instead of multiplied. The second way they differ is that if you buy a Mastery Study in a certain row, and the row above is incomplete, you will no longer be able to complete that row. This barrier can be removed by obtaining the Achievement "Seriously, I already got rid of you", but that's for a much later period of time.

MS11, which multiplies IP gain by 2.1x, will be available at 1e69 TT, and you should immediately purchase it once you can afford it. After this, it's a good idea to take the MS 22 split for your first second-row study at 1e70 TT, as not only is it more powerful depending on how many TGs you have, but it also allows you to get the upgrade you should focus on for your first TT push: MS34 at 4.5e69 TT, which multiplies TP gain by 5x.

At this point, you'll need to start alternating your setups while waiting to afford the next MS. Use the MS21/22 splits, excluding MS34, to push EP production. After passing 1e71 TT, make sure to get the bonus from "Universal harmony" by respeccing your MS build to 11/23/35,36. Your goal here will be to push your TT to at least 1e73 to attempt EC13-14x1.

EC13x1 (1e980,000+ EP / 900,000 Dimension Boosts / 4e72+ TT | Goal: 1e276,000,000 IP): Your goal in this challenge will be to push your IP as high as you can using your EP mult and TDs. It's easier to do this by taking the full MS21 path and then taking MS22-33, while leaving 34 untouched. If you've set everything up correctly, you'll complete the challenge in a few seconds or minutes. Reward: Everything except MA boosts the power of Dimension Boosts more.

EC14x1 (1e975,000 EP / 1e250K Replicanti / 7e70+ TT | Goal: 1e315,000,000 IP): Your goal in this challenge is to maximize the boosts you get from non-Replicanti sources, since your Replicanti amount is locked at 1 for the duration of the challenge. You should get mastery studies 11,21,22,33,34 for this challenge, which will make it extremely easy and allow you to finish it in a few seconds.

By the end of this stage, you should be sitting around e1e6 EP and e8e10 AM, at which point your final task is to grind your MA to 2.08e385, which is probably already done. Once you've done this, you can finally move onto the next layer: Quantum!

Time and Mastery Study setups for this stage:

1. 11,21,22,33,31,32,41,42,51,61,62,71,72,73,81,82,83,91,92,93,101,102,103,111,123,133,143,151,161,162,171,181,191,192,193,211,212,213,214,222,224,226,228,231,232,233,234|ms11,22,21,34,33,32|0 - Prioritizes TP production in dilated runs.
2. 11,21,22,33,31,32,41,42,51,61,62,71,72,73,81,82,83,91,92,93,101,102,103,111,123,133,143,151,161,162,171,181,191,192,193,211,212,213,214,222,224,226,228,231,232,233,234|ms11,22,21,33,32,31|0 - Prioritizes EP production outside of dilated runs.
3. 11,21,22,33,31,32,41,42,51,61,62,71,72,73,81,82,83,91,92,93,101,102,103,111,123,133,143,151,161,162,171,181,191,192,193,211,212,213,214,222,224,226,228,231,232,233,234|ms11,23,36,35|0 - Use this build to get "Universal harmony" after e71 TT.
4. 11,21,22,31,32,33,41,42,51,61,62,73,71,72,83,81,82,93,91,92,103,101,102,111,123,133,143,151,161,162,171,181,191,192,193,211,212,213,214,222,224,226,227,231,232,233,234|ms11,22,21,33,32,31|0 - Use this build to attempt EC13x1.
5. 11,21,22,31,32,33,41,42,51,61,62,73,71,72,83,81,82,93,91,92,103,101,102,111,123,133,143,151,161,162,171,181,191,192,193,211,212,213,214,222,224,226,227,231,232,233,234|ms11,22,23,33,35,36|0 - Use this build to attempt EC14x1.

### Time Dilation/Meta Dimensions/Mastery Studies Achievements

* **I'm so meta:** Unlock Meta Dimensions. Reward: TS121 and TS122's multipliers are always 50x.
* **And still no ninth dimension...:** Buy MD8. Reward: 100 MA on reset, and all MDs are 10% stronger.
* **In the grim darkness of the far endgame:** Have e4e4 (e40,000) EP. Auto-unlocks shortly after MDB 3-4. Reward: 2x DT and TP gain.
* **GAS GAS GAS:** Get 1,000,000 tickspeed upgrades from TDs. Auto-unlocks almost immediately after obtaining the e60 DT upgrade. Reward: EP mult and TD autobuyers.
* **Meta-boosting to the max:** Get 10 MDBs. Auto-unlocks shortly after the 1e60 DT upgrade. Reward: MDBs are 5% stronger.
* **The cap is a million, not a trillion:** Have 1e12 Eternities. Get this after the 1e80 DT upgrade; the closer you wait until e100 DT to attempt, the easier it is to obtain. Reward: Eternity Upgrade 2 and TS231 use a better formula.
* **It will never be enough:** Have e6e4 (e60,000) Replicanti. Auto-unlocks at around e60-e70 DT.
* **Universal harmony:** Have 700 of each type of galaxy. Requires a filled MS35/36 path at e8e5 EP. Reward: Galaxies are 0.1% stronger and you gain 10x more Infinitied/Eternitied stat.

## Quantum Era

### Quantum: Second Quantum

Depending on your MA, you will start your second Quantum with 1 or 2 - or anywhere from 3 to 20 if you've pushed a VERY idle build for MA production - Anti-Quarks. You can assort these to different colors, which generate Color Power based on their amount that improve specific bonuses - Red color power increases the strength of all types of Galaxies, Green color power reduces the scaling of the replicate interval, and Blue power increases TP production. Also, upon going Quantum, you immediately earn the Achievement "Sub-atomic", which cuts all MS costs permanently in half, eliminates the requirement to unlock Time Dilation, and allows you to start every Quantum with 100 Eternities.

A major part of Quantum is Quantum Energy, which is gained by progressing through increasingly long Quantums and gaining more aQK per run, and is crucial for a later part of Quantum which you are currently not far enough to obtain just yet.

You've now also unlocked a new layer of boosts called the Quantum Milestones. Accessible through the Milestones tab, there are currently 27 Milestones, though you'll only see the first three. Milestones are unlocked through Milestone Points earned through four methods: Speedrun (going Quantum in under certain periods of time), Energetic (completing Quantums at certain amounts of QE), Relativistic (completing Quantums with certain amounts of TP), and Challenging (completing certain amounts of Paired Challenges, which doesn't come until much later). Upon going Quantum for the first time, you've unlocked at least QM1, which allows you to retain your studies upon completing an Eternity Challenge. If you've gained more than 1 aQK, you've also unlocked QM2, which unlocks the Time Theorem autobuyer, multiples your starting Eternities by 3number of Milestones, and allows you to keep your Eternity Challenge completions. Don't worry if you don't immediately have QM2, as you'll automatically have it before the end of this Quantum run.

After you go Quantum for the first time, assort your first aQK to first Red, then Blue, then finally Green. Alternatively, if you have 3 or more, you can use the "Distribute" button in the bottom left corner of the page and the game does the math for you. If you have enough to Distribute, then congratulations, you just got "Hadronization" for free! This Achievement lets your Quantum Worth (the sum of all your aQK, colored aQK and anti-Gluons) boost your Meta Dimensions.

If you don't have QM2 yet, your goal will be to push back up to Quantum and re-complete the Eternity Challenges as you do so, roughly following the order set forth in the vanilla Guide. Quantum will make these challenges a lot easier, so it won't take nearly as long to reach Dilation again. By the time you're back at Dilation, runs will progress significantly faster thanks to the Blue color power boost. You should be able to Quantum within an hour, and you should do so immediately. Once you've gone Quantum your second time and assorted your aQK to two or more colors, you unlock the next mechanic: Anti-Gluons and Entangled Boosts. You'll also automatically unlock QM3-4, which respectively lets you keep your Eternity Upgrades and Time Studies through Quantums, and unlocks the Dilation autobuyer and new modes for the Eternity autobuyer.

### Quantum: Third to Fifth Quantum

Anti-Gluons are generated automatically upon going Quantum using the assorted aQK from before, and boost your QE gain and Entangled Boosters' power, depending on which type of Anti-Gluon you have selected. They also boost one type of color power, but subtract the next in the cycle.

Entangled Boosts are a set of 12 boosts that unlock based on how many Entangled Boosters you have, which themselves are based on your best QE. There are higher requirements to Master them, but upon doing so, they remain active regardless of the type of Anti-Gluons you have selected. You automatically unlock the first two Entangled Boosters with your current QE, and will unlock more later. A table with the different Boosts, what requires them, and what they do, will be provided below.

Upon unlocking EB1, you also automatically gain QM5 - and QM6, depending on your progression. QM5 leaves Time Dilation unlocked and allows the 3x TP Dilation upgrade to be retroactive, meaning buying the upgrade eliminates the need to Dilate, as you'll get the 3x TP instantly. QM6 unlocks QoL in the forAm of unlocks for all TDs for immediate use at the start of every Quantum. You should also be able to unlock EB2 if you've progressed enough.

At this point, you'll enter an inflation period where your focus will be on pushing your QE and MP as high as you can to get the next QM and continue unlocking EBs. You'll immediately notice upon DIlating that Dilation has sped up significantly again thanks to the retroactive 3x TP gain.

After you perform your third Quantum, you should push your EP as far as you can using MS21-31, 22-33,34, 23-35-36. Your goal is 1e1,500,000 EP, at which point you can unlock Eternity Upgrade 8, which lets you buy all the TS22x studies. After getting Eternity Upgrade 8, it's time to go back to going for your fourth Quantum, if you don't have it already.

Upon going Quantum, you'll immediately unlock QM7-8 and maybe 9 depending on how fast this Quantum was. QM7 lets you keep all non-rebuyable Dilation upgrades, QM8 lets you keep the first 25 levels of the TP gain rebuyables, and QM9 starts every Quantum with MDs unlocked. Your goal this Quantum is to get enough TT to maximize your EP and MA by swapping MS34 for MS32 from the last Quantum. Once you have at least 1e2,000,000 EP, go Quantum again.

You'll immediately gain QM10-11. QM10 lets you keep your Mastery Studies through Quantum (meaning you just saved a lot of time getting those MS from before you went Quantum, as you now have those until you choose to respec them!), and QM11 grants QoL in the form of the Dilation rebuyables autobuyer and the "Buy all time studies" button. Go ahead and turn that on so you don't have to worry about going back and forth. At this point, you no longer need to go to the Dilation page, just press D to dilate, wait a few seconds, then press E to get your TP. Also, now that you've gone Quantum again, go ahead and distribute your aQK to improve your Anti-Gluon boosts next Quantum.

### Quantum: Speedrun Era

At this point, it's time to focus on getting more QM by pushing your Quantum speed. The goal is simple: dilate and buy MDBs as fast as you can and click the big green Quantum button as soon as you see it. It's also helpful you have the Quantum confirmation turned off for this part of progression. Also, at this point, make sure you have your Anti-Gluons set to Green-antiblue, as the Red-type EB1 is already Mastered and no longer needs Red selected to have its effect. Your goal is to get the next QoL feature through QM: QM14, which automates MDBs and starts you off with 4 MDBs (meaning MD8 is always available for purchase). Along the way, you'll also get QM12, which reduces the interval of the rebuyables and MD autobuyers by 10% per QM earned, and QM13, which reduces the interval of MDs again by 1 tick per QM earned. Note that both of these QM are retroactive, meaning the boosts take into account the QMs completed before them.

You should now grind around 15 red quarks to make galaxies stronger, and start using the distribute function to maximize gluon gain without compromising your color charge. Red quarks are currently the strongest type of quark, so this strategy will optimize progression for now.

You'll be able to advance to the next stage and push for enough QE to get EB4 at this point, which should be no more than three Quantums away. After that, your main goal is to focus on pushing Quantum and getting 8 Entangled Boosts to Master EB2 so you can take advantage of the Mastery to activate EB4. While pushing for EB4, it's possible to get QM15 by holding Q and forcing a Quantum before your MDB autobuyer can reset your MDs at e385.

Once you hit 50 Quantum Worth, it will be time for a long Quantum to get to 1e2,400,000 EP, at which point you'll be able to unlock Eternity Upgrade 9 and finally attempt EC13x2. When buying Eternity Upgrade 9, make sure you're setting your 2-2 split to Active, and combine it with Idle.

EC13x2 (1e2,600,000+ EP / 945K Dimension Boosts / 6.44e74 TT | Goal: 1e320,000,000 IP): After getting in this challenge, your IP and EP production will skyrocket, so it's a short wait to get to the goal, but if that doesn't work, either wait a little longer or Crunch a few times to get the IP required to complete the challenge.

After completing EC13x2, EC13x3-4 are free, so run those real quick. EC13x5 is too difficult to attempt for the moment. Also, once you go back to normal runs, you'll earn the Achievement "Old age", which gives you a multiplier to MD1-3 based on your current AM.

Keep grinding gluons until you reach 5.3 quantum energy. Long runs are now more efficient for getting more anti-quarks, but you should still do speedruns for more milestones. You should be aiming for a time of 23 seconds - this will make MDB's no longer reset meta dimensions and will allow you to get anti-quarks even faster.

### Quantum Era: Positrons

Positrons involve sacrificing your MDBs, quantum charge and galaxies for Positrons and Positronic Charge. This seems like a bad thing at first, but will allow you to gain Positronic Boosters, which are basically a continuation of Entangled Boosters. The first Positronic Boost, a G-type boost, makes quarks stronger based on replicanti. However, the gluon Entangled Boosts and Positronic Boosts has to be the same - for example, you cannot use Entangled Boosts with GB and Positronic Boosts with RG

**Positronic Boosts List and Requirements**
 PB2 - Pata Accelerator - Blue

Unlocking Positrons has also unlocked more mastery studies - the first new study (MS41) is free, so you can buy it right now - however, the others are likely too expensive for now. You have also unlocked a new source of Milestone Points (Relativistic), which is based on best Tachyon Particles - however, the first point requires 1e90 TP, which is several orders of magnitude above your current state.

Keep getting more TP and MA until you are able to get the 3rd Positronic Booster. This will unlock a new B-type Positronic Boost, which in turn unlocks the Meta-Accelerator when active. This will boost DT, MA and the replicanti interval based on time in this quantum, so you should now switch gluons to GB.

You'll soon be able to unlock 2 more Entangled Boosts, a B-type boost which boosts replicanti gain and a G-type boost which makes MDB's stronger. Now do a long run and get 9e76 total TT - depending on how active you are this can take up to 2 hours. This will allow you to get mastery studies 42 and 52, which will boost red power and let you buy more replicate interval upgrades.

You should now turn your red quarks into RG gluons and get a surplus of blue quarks, as MS42 makes red quarks basically useless. Keep grinding more quantum energy until you can buy the 12th Entangled Booster, which will unlock two new Entangled Boosters. The first one, a G-type reduces the cost scaling of the 4th dilation upgrade (TP formula exponent increase), while the second, an R-type, makes DT boosts MA gain.

Once you reach 1.25e88 total TT, respec your mastery studies and import the tree 11,21,22,33,31,32,41,42,51,61,62,71,72,73,81,82,83,91,92,93,101,102,103,111,121,123,131,133,141,143,151,161,162,171,181,191,192,193,211,212,213,214,221,222,223,224,225,226,227,228,231,232,233,234|ms11,22,21,23,36,35,33,32,31,34,41,42,51,52,53|0 to massively increase replicanti gain. At 5.35e88 TT, buy MS54 (You'll have to respec and buy 51 and 54 before 52 and 53).

Do a long run and grind 1e93 TP - this will allow you to get the 1e80 TT required for Quantum Challenges in around three hours. You should get the positronic charge required automatically - if you can't, try grinding more quarks and gluons.