Full8

Quote | ReplyDayspring has some interesting comments about how 3-BP crosses the blood brain barrier. This has been a somewhat murky topic. Thankfully they have provided an update on this important topic.

http://www.dayspringcancerclinic.com/why-3bp/

Dayspring also appears to be providing more information on their case studies for 3-BP. They now have 2 stage IV patients who seem to be doing quite well after 3-BP treatment. More detail would be great (e.g. was this IV 3-BP, more updates, etc.), though it is helpful that they are providing this information. The patients they are presenting appear to have had very serious cancer.

http://www.dayspringcancerclinic.com/3bp-cases/
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### RE: where to get 3dp and in what form for oral use?

by bella20 on Thu Jun 18, 2015 12:06 PM
Quote | ReplyHi ,

Anyone had colon cancer that had high CEA and can't see anything show on scan.So  scaring for CEA jumped so high please share . I have IV for 3 BP about more than a week after I take pill 2 pill/day. But CEA still jumping.

Thanks
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### RE: where to get 3dp and in what form for oral use?

by kcervantes on Thu Jun 18, 2015 12:23 PM
Quote | ReplyWere they able to use the contrast with you CT?  My husband has stage 4 colon cancer and had a CT prior to surgery showing spots on liver, etc but when they operated he had 3 small tumors attached to the outside of his large intestine that were undetectable on the scan.  You might want to ask for an MRI w/ contrast
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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Thu Jun 18, 2015 12:35 PM
Quote | ReplyI think this a great idea Jcancom.  More people need to know about this thread.  It gives people hope and allows them to take control of their situation :)
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Freyr on Thu Jun 18, 2015 01:27 PM
Quote | ReplyNote that the patient cases reported by Dayspring are not backed by medical documentation - I've seen these kind of reports backing Gerson therapy "effectiveness". The liver patient and the melanoma patient both had extensive clinical data describing their response.

I wonder why didn't the Sohag Cancer Institute for example treat more patients with 3BP? IF their patient had such an overwhelming response, we should expect a true explosion of other reports from the same institution at least - yet they're limited to a giant sample of n=1. Why?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jun 18, 2015 01:31 PM
Quote | ReplyI wonder whether there could be some way for those patients with severe metastatic cancer to access charitable donations for 3-Bromopyruvate treatment. Patients who seek out 3-Bromopyruvate treatment must pay for their treatment out of pocket. This can be a challenge for many people. There is a whole lot of cancer research money/ cancer foundation money etc. that is floating around out there. If there were some way to link up the money to those who need it for treatment, then things could move forward quickly.

I also wonder whether some insurance plans might at some point open up coverage for 3-BP in some of their patients. The traditional method of treating terminal cancer patients (even with a palliative care philosophy) can be extremely expensive. Many of these patients can suffer tremendous amounts of pain, though still live. Insurance companies  save a substantial amount of money by relaxing their treatment funding guidelines. They would also be making the morally correct choice.  Such a decision would unlock the cure for cancer. After all insurance companies should really only be understood as being guardians of people's own money. If someone with insurance has terminal cancer without traditional medical options, then who is for the insurance company to make all sorts of restrictions on how someone should go about treating themselves?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Thu Jun 18, 2015 02:01 PM

Quote | Reply

On Jun 18, 2015 5:31 PM Jcancom wrote:

I wonder whether there could be some way for those patients with severe metastatic cancer to access charitable donations for 3-Bromopyruvate treatment. Patients who seek out 3-Bromopyruvate treatment must pay for their treatment out of pocket. This can be a challenge for many people. There is a whole lot of cancer research money/ cancer foundation money etc. that is floating around out there. If there were some way to link up the money to those who need it for treatment, then things could move forward quickly.

I also wonder whether some insurance plans might at some point open up coverage for 3-BP in some of their patients. The traditional method of treating terminal cancer patients (even with a palliative care philosophy) can be extremely expensive. Many of these patients can suffer tremendous amounts of pain, though still live. Insurance companies  save a substantial amount of money by relaxing their treatment funding guidelines. They would also be making the morally correct choice.  Such a decision would unlock the cure for cancer. After all insurance companies should really only be understood as being guardians of people's own money. If someone with insurance has terminal cancer without traditional medical options, then who is for the insurance company to make all sorts of restrictions on how someone should go about treating themselves?
Slightly off-topic. We have a very good oncological naturopath and today are having an artesunate/laetrile/nutrient IV. When I mentioned 3BP to this fellow, he hadn't heard of it, which kind of disappointed me. However, he said, "There are lots of things that achieve the same objective." I assume he meant block the cancer cells' ability to get sugar. I will pursue this more today. We were very rushed last time as we were half an hour over our time with clients waiting outside. Artesunate causes cancer cell death when the iron they store turns against them as artesunate enters the cell and uses the iron to create ROS, and we all know about laetrile, which seems to have a synergistic effect. Now if we can add something 3-BPish to this...
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jun 18, 2015 02:13 PM
Quote | ReplyI think pathological sketicism is a large part of the reason why 3-Bromopyruvate has never taken off.

Cancer in the public imagination is considered completely uncurable. It is simply understood to be an unsolvable problem. Those knowledgable in cancer would know that life expectancy for metastatic cancers has never increased, even with the research investment of likely trillions of dollars. Such an abysmal outcome simply would not apply to almost any other illness. If we were to throw enough money at almost any other medical problem there would almost certainly be treatment gains. There have been virtually no treatment gains ever acheived in all forms of late stage cancer.

So, it has been an uphill struggle convincing people that a commonly used and inexpensive fungicide can cure cancer.

There is almost no commercial interest in developing this product. In fact, there are a whole range of glycolytic inhibitors that might be effective in treating cancer that have likewise not generated much commercial enthusiasm. So for example, methylglyoxal. These results are very encouraging.

http://www.cancer-therapy.org/CT/v4/B/HTML/17.%20Talukdar%20

It should be noted that the people behind 3-BP and those who have endorsed it are not quacks. A large part of the Nobel prizes won in the early to mid 20 th century were awarded to metabolic chemists. There are quite a few of them. One of the Nobel prize winners advanced methylglyoxal as a cancer treatemnt over 50 years ago. The initial results in humans were positive. For some reason this line of research disappeared. It is now reemerging and the results appear quite favorable.

There might be legal reasons behind Dayspring's brief patient reports. The FDA might not allow claims to be made or appear to be made for a product that has not been approved. Further, such reports would be considered to be only anecdotal. However, it should be noted that the patients that Dayspring has published on their site were treated not long after they started offering treatment. Considering they are charging about $30,000 and the reported patients were treated soon after they offered treatment it is not difficult to imagine that the reported patients are from a small selection pool. So, there is likely not much selection involved. With many other alternative treatments, they have been around for so long that it is quite possible that they are highlighting one successful patient among thousands of failures.

It is difficult to understand why this has not moved ahead more. Yet, it should be noted that 3-BP has made substantial strides forward in the last year. If you look back on this thread, it was not until September, 2014 that there was even a slight amount of general interest in this treatment. As soon as the melanoma patient report was published, it became more widely appreciated that IV 3-BP treatment could be applied to almost all cancer patients. 3-BP has been steadily building since that point.

So there are a whole bunch of factors that have worked against 3-BP uptake: skepticism, commercial interests, cost of treatment, scientific reporting etc. . It will be interesting to see when a breakthrough point will be reached.

Such a point appears to be nearing. The price point for treatment has moved down. Very good patient populations have been identified (e.g. pancreatic and liver/bile duct). Funding ideas have been proposed (e.g. gofundme and Indiegogo life). Social media are onboard (e.g. we have a cure).

Everything seems to be in place for a launch.

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jun 18, 2015 02:30 PM
Quote | ReplyOne of the 3-BPish compounds that has generated quite a bit of off thread interest amongst the posters is methylglyoxal.

Methylglyoxal is naturally produced at the front end of glycolysis, though it is somewhat toxic to cells. (Yet, an Indian clinical trial dosed cancer patients with almost 2g per day for many many years without any side effects. A new form of methylgloxal (Chitosan methylglyoxal nanoparticles) that is even safer and more effective has been reported.)

Cancer cells are particularly vulnerable to methylglyoxal because glycolysis supplies 50% of their energy needs. To accomplish this, they need to detoxify all the methyglyoxal produced. This is achieved in cancer cells by Glo1. Glo1 is massively increased in cancer cells.

Without Glo1 and with extra exogenous methylglyoxal cancer cells would be placed under considerable stress. It just so happens that curcumin is one of the most effective Glo1 inhibitors yet found. Combining curcumin with methylglyoxal could make quite an effective anti-cancer treatment.

The Indians have patented a cancer treatment based on this idea. In their full patent, they combine methylglyoxal creatine, melatonin, and ascorbic acid and report quite impressive results in mice. There is no mention of curcumin in the patent. The creatine can help prevent cardiovascular side effects.

This methylglyoxal combination might be a good add on combination or a stand alone combination for you, though I am very unsure if it would really help with the laetrile etc.

I am also interested in how methylglyxoal might combine with 3-BP. I suppose it could be a good combination, though I am not sure.

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### RE: where to get 3dp and in what form for oral use?

by mahkcots on Thu Jun 18, 2015 02:33 PM
Quote | ReplyDoes anyone have any information about the efficacy of 3BP delivered through an IV as opposed to intra-arterial delivery for liver cancer. I have come to understand that the most effective way to deliver 3BP is not by IV, however, in my search for clinics all I can seem to find is the IV option or for some reason, enema. Does anyone know why this is and if it is possible to find a clinic that does not use IV.
Quote | Reply

### RE: where to get 3dp and in what form for oral use?

by Jcancom on Thu Jun 18, 2015 02:41 PM
Quote | ReplyThe only hard evidence for IV 3-BP was the liver cancer patient. IV 3-BP should be near the top of the list in terms of treating systemic cancer. Inhalation 3-BP might also be at or near the top, though there has been no human clinical reports yet published for this route.

I have not hears of the enema route before. Do you have a url for that?

IV would be the obvious choice as it it the most medicalized and most commercially attractive. Nebulized 3-BP has considerable appeal though is less commercially favored. It was noted earlier on this thread that medicine has not been particularly creative with different dosing approaches. Even intra-nasal dosing for brain tumors has only recently been investigated.

The Toronto clinic was reporting use of intra-tumoral injections.
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### RE: where to get 3dp and in what form for oral use?

by bella20 on Thu Jun 18, 2015 03:08 PM
Quote | ReplyHi kcervantes,

yes, I did the contrast and without contrast, but can't see. 6 months ago I did the PET scan too.and  6 months ago I had the PET scan still didn't show any . But CEA jump horrible
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jun 18, 2015 03:15 PM
Quote | ReplyIt should also be noted that the published reports for the liver and melanoma patient even though they have been reported in peer reviewed scientific publications are only patient reports. There could have been pulication bias involved with them. This is why it is important for sequentially treated patients to be reported.

Please reply to this post in future posts as the other topic heading has 3dp!
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### RE: where to get 3dp and in what form for oral use?

by Danielus on Thu Jun 18, 2015 04:01 PM

Quote | Reply

On Jun 18, 2015 7:08 PM bella20 wrote:

Hi kcervantes,

yes, I did the contrast and without contrast, but can't see. 6 months ago I did the PET scan too.and "" target="\_blank" rel="nofollow">http://too.and " target="\_blank" rel="nofollow">too.and  6 months ago I had the PET scan still didn't show any . But CEA jump horrible
Bella20, if it is not visible on PET, there is no point for using 3BP. Dont spend time with anti-glyco elements. Instead use elements such as phenyl butyrate to target glutamine, avoid food containig glutamine and use elements targeting mito such as Metformin, Doxyclicline, etc. Artemisinin should also be suitable or IV Vit C
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### RE: where to get 3bp and in what form for oral use?

by Jcancom on Thu Jun 18, 2015 04:16 PM
Quote | ReplyEveryone it's not 3dp!!!!

Please correct the subject line if necessary.

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### RE: Post Figure for the 3BP thread

by Jcancom on Thu Jun 18, 2015 08:02 PM
Quote | ReplyJust click on the figure for an enlargement.
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### RE: where to get 3dp and in what form for oral use?

by mahkcots on Thu Jun 18, 2015 11:06 PM
Quote | ReplyI have spoken witht the Dayspring Clinic and they made it clear that they used a combination of IV's and enema's. I was under the impression that the liver cancer patient that was treated in Germany was given 3BP by intra-arterial injection.
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### RE: where to get 3dp and in what form for oral use?

by Jcancom on Thu Jun 18, 2015 11:08 PM
Quote | ReplyDid Dayspring clearly indicate what route of administration the 3-BP is given?

Do they give 3-BP by enema?
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### RE: where to get 3dp and in what form for oral use?

by Meech90 on Fri Jun 19, 2015 12:23 AM

Quote | Reply

On Jun 19, 2015 3:06 AM mahkcots wrote:

I have spoken witht the Dayspring Clinic and they made it clear that they used a combination of IV's and enema's. I was under the impression that the liver cancer patient that was treated in Germany was given 3BP by intra-arterial injection.
The Hepatocellular Carcinoma patient was intra-arterially whereas the Melanoma patient was IV.Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitter mahkcots

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### RE: where to get 3dp and in what form for oral use?

by mahkcots on Fri Jun 19, 2015 01:52 PM
Quote | ReplyIn the email I recieved from Dr. Dickens, "Lastly we have been doing more general 3bp treatments (oral, IV, enema) and while not as speedy, they do work. " Also the cancer center that was mentioned in Canada only offers treatment to Canadian citizens.
Quote | Reply

### RE: where to get 3dp and in what form for oral use?

by Jcancom on Fri Jun 19, 2015 02:32 PM
Quote | ReplyWonder if Dayspring also offers nebulized 3-BP. This seems to be one of the smarter routes of admisitration.
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### RE: where to get 3bp and in what form for oral use?

by Jcancom on Fri Jun 19, 2015 08:44 PM
Quote | ReplyI have been posting to the pancreatic cancer threads about the possible use of it in end stage cancer. All of these comments appear to have been removed mention as were those made this on our thread.

I find to very difficult to understand why such comments would be removed. Many of the patients on the pancreatic threads have no viable treatment options. In fact, many of these patiens are even too sick to receive chemotherapy. For them 3-BP might be their only chance for survival. The FDA appears to agree with this assessment as they have given orphan designation for pancreatic cancer  with 3-BP treatment.

At some point we might need to relocate our thread. It is so important for many terminally ill cancer patients to be made aware of possible treatments such as 3-BP
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### RE: where to get 3bp and in what form for oral use?

by Jcancom on Fri Jun 19, 2015 10:00 PM
Quote | ReplyHas there been any confirmation from the Alabama clinic that they do in fact offer 3-BP?
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### RE: where to get 3bp and in what form for oral use?

by Jcancom on Fri Jun 19, 2015 10:10 PM
Quote | ReplyA post from June 10, 2015 noted that shivering was a result of a fast increase in uric acid levels which would indicate a fast anti-tumor response. Uric acid increases are also related to tumor lysis syndrome.
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### RE: where to get 3bp and in what form for oral use?

by mahkcots on Sat Jun 20, 2015 01:34 AM
Quote | ReplyI am currently waiting for a reply from their clinic. when I asked about the possibility of a 3BP treatment I was told to send my medical records and they would be reviewed. I expect a reply from Dr. Williams later this week and I will let you know what he says.
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### RE: where to get 3bp and in what form for oral use?

by Moonlitnight on Sat Jun 20, 2015 01:41 AM

Quote | Reply

On Jun 20, 2015 5:34 AM mahkcots wrote:

I am currently waiting for a reply from their clinic. when I asked about the possibility of a 3BP treatment I was told to send my medical records and they would be reviewed. I expect a reply from Dr. Williams later this week and I will let you know what he says.
Same here. Told to send records and then they would let me know the appropriate treatment. All I want to know is do they offer 3BP as we are getting "appropriate treatment" through an oncology naturopathic physician here.
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### RE: where to get 3bp and in what form for oral use?

by mahkcots on Sat Jun 20, 2015 02:46 AM
Quote | ReplyHow long ago did you send your medical records? I overnighted mine and they should have arrived today. Are they in any way ignoring you or not replying?
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### RE: where to get 3bp and in what form for oral use?

by mahkcots on Sat Jun 20, 2015 02:15 PM
Quote | ReplyFor all who are interested: I recieved a reply from Dr. Williams this morning. He does offer 3BP treatments however he is becoming opposed to their use and is relying more upon immunotherapy treatments. He said that as he works with 3BP he has found that it kills tumors but if complete eradication is not acheived they come back much more aggressively. He also commented that the treatments generally make the patients so sick that they skip the next round which causes te tumors to come back aggressively and retake what was lost plus some of the healthy cells. He is willing to do it if you pay but for patients with a high tumor load it should be regarded as a nuclear option.
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### RE: where to get 3bp and in what form for oral use?

by Moonlitnight on Sat Jun 20, 2015 02:23 PM

Quote | Reply

On Jun 20, 2015 6:15 PM mahkcots wrote:

For all who are interested: I recieved a reply from Dr. Williams this morning. He does offer 3BP treatments however he is becoming opposed to their use and is relying more upon immunotherapy treatments. He said that as he works with 3BP he has found that it kills tumors but if complete eradication is not acheived they come back much more aggressively. He also commented that the treatments generally make the patients so sick that they skip the next round which causes te tumors to come back aggressively and retake what was lost plus some of the healthy cells. He is willing to do it if you pay but for patients with a high tumor load it should be regarded as a nuclear option.
Oh my...in this sense then it is like chemo - kills off the weakest cells, leaving the stem cells to multiply (as well as causing mutations). What does this mean? "but for patients with a high tumor load it should be regarded as a nuclear option"? Nuclear?  I thought it had very little, if any, SEs.

Thanks for your research!
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### RE: where to get 3bp and in what form for oral use?

by Moonlitnight on Sat Jun 20, 2015 02:24 PM
Quote | ReplyAlso, did he say what the immunotherapy treatments were?
Quote | Reply

### RE: where to get 3bp and in what form for oral use?

by jetsparkle on Sat Jun 20, 2015 02:26 PM

Quote | Reply

On Jun 20, 2015 6:15 PM mahkcots wrote:

For all who are interested: I recieved a reply from Dr. Williams this morning. He does offer 3BP treatments however he is becoming opposed to their use and is relying more upon immunotherapy treatments. He said that as he works with 3BP he has found that it kills tumors but if complete eradication is not acheived they come back much more aggressively. He also commented that the treatments generally make the patients so sick that they skip the next round which causes te tumors to come back aggressively and retake what was lost plus some of the healthy cells. He is willing to do it if you pay but for patients with a high tumor load it should be regarded as a nuclear option.
This may be discouraging then...I do not quite understand how one would know if complete eradication takes place--PET/CT scan?  Then does that mean also that one must be sure there are no more CSC's?  And how would a patient get that information--second thought about that--perhaps through RGCC testing.

And need further explanation about patients with a high tumor load that "it should be regarded as a nuclear option"?  Don't quite understand that--anyone help me out with what that actually means?
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### RE: where to get 3bp and in what form for oral use?

by jetsparkle on Sat Jun 20, 2015 02:30 PM

Quote | Reply

On Jun 20, 2015 6:23 PM Moonlitnight wrote:

On Jun 20, 2015 6:15 PM mahkcots wrote:

For all who are interested: I recieved a reply from Dr. Williams this morning. He does offer 3BP treatments however he is becoming opposed to their use and is relying more upon immunotherapy treatments. He said that as he works with 3BP he has found that it kills tumors but if complete eradication is not acheived they come back much more aggressively. He also commented that the treatments generally make the patients so sick that they skip the next round which causes te tumors to come back aggressively and retake what was lost plus some of the healthy cells. He is willing to do it if you pay but for patients with a high tumor load it should be regarded as a nuclear option.
Oh my...in this sense then it is like chemo - kills off the weakest cells, leaving the stem cells to multiply (as well as causing mutations). What does this mean? "but for patients with a high tumor load it should be regarded as a nuclear option"? Nuclear?  I thought it had very little, if any, SEs.

Thanks for your research!
Looks like we were thinking along the same lines--as I was typing my thoughts--you were also.  Hope we get further answers to our thoughts/questions!
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### RE: where to get 3bp and in what form for oral use?

by Moonlitnight on Sat Jun 20, 2015 02:34 PM
Quote | ReplyMe too, Jetsparkle.
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### RE: where to get 3bp and in what form for oral use?

by Jcancom on Sat Jun 20, 2015 02:58 PM
Quote | ReplyIt is disappointing that some of the early adopter doctors have turned against 3-BP. They are among only a small number of doctors who would have actual treatment experience with it.

At the same time the published articles mentioned none of these voiced concerns. Neither of the two published patients experienced any side effects from 3-BP treatment. In fact, the only reported response made by both patients was they  immediately felt better.

In terms of resistance to treatment, the liver patient received monthly injections of 3-BP for almost a year. At the end of his treatment, even though he started with a massive tumor burden, no live cancer could be found. The melanoma patient had a similar response. It would seem that a cancer cell might find it difficult to develop resistance to 3-BP, as 3-BP targets the cancer cells energy pathway.

Patients who received treatment with 3-BP might need to fully commit themselves to ongoing treatment. Perhaps just having a single round of treatment would be like taking a half dose of antibiotics, you would only be selecting for the resistent cells.

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### RE: where to get 3bp and in what form for oral use?

by mahkcots on Sat Jun 20, 2015 03:12 PM
Quote | ReplyBy nulear option he meant an absolute last resort because he does offer 3BP but is opposed to its use in patients with a higher tumor burden due to the results that he has seen in his treatments. As to the immunotherapy, he is offering embolization followed promptly by injections of PD1 and other such chemicals.
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### RE: where to get 3bp and in what form for oral use?

by jetsparkle on Sat Jun 20, 2015 04:15 PM

Quote | Reply

On Jun 20, 2015 7:12 PM mahkcots wrote:

By nulear option he meant an absolute last resort because he does offer 3BP but is opposed to its use in patients with a higher tumor burden due to the results that he has seen in his treatments. As to the immunotherapy, he is offering embolization followed promptly by injections of PD1 and other such chemicals.
I wonder what numbers he uses to distinguish a "higher tumor burden"--what would be his determining tumor markers for such.

It seems that a while back I read about his treatments and was very impressed with his use of RFA and cryoablation techniques--there, too, he had mentioned the usage of injections of current conventional drugs--perhaps one was Yervoy--but  I would have to read some articles again to remember exactly what he had used--several options, I would assume considering the individual's cancer, etc.

I do think he is to be highly commended for his usage of cryo and RFA--these techniques certainly have the advantage over typical  surgery methods  that, generally speaking, have the propensity to spread  cancer.

Cryoablation is not generally done-or really accepted yet--nor covered by insurance-- for breast cancer patients--and it is a pity--why not?  Too many times after breast surgery, there is a lymphatic spreading of the cancer--and then the mets follow.
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### RE: where to get 3bp and in what form for oral use?

by mahkcots on Sat Jun 20, 2015 04:48 PM
Quote | ReplyThe drugs he mentioned were Yervoy, Optdivo and Keytruda along with Dendritic cell vaccine, Matrix M, Montanide and CpG. He also said patients take cyclophosphamide 50 mg every other day, for 1 month to decrease T regulatory cells.  Also, the drug Januvia (approved for diabetes) it is a DIPP4 inhibitor which increases anti-tumor cytokines and enhances the immune response.
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### RE: where to get 3bp and in what form for oral use?

by jetsparkle on Sat Jun 20, 2015 04:56 PM

Quote | Reply

On Jun 20, 2015 8:48 PM mahkcots wrote:

The drugs he mentioned were Yervoy, Optdivo and Keytruda along with Dendritic cell vaccine, Matrix M, Montanide and CpG. He also said patients take cyclophosphamide 50 mg every other day, for 1 month to decrease T regulatory cells.  Also, the drug Januvia (approved for diabetes) it is a DIPP4 inhibitor which increases anti-tumor cytokines and enhances the immune response.
Thank you so very much for that update about the meds, etc.

It would be interesting to learn the success rate he has with using them--and of any subsequent difficulties.   I know there are side effects with most--wary of that.  But, then again, with cancer we cannot let things go either.

Very much appreciate your sharing of all of this information you received from him--so many of us are trying to determine just what to do.
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### RE: where to get 3bp and in what form for oral use?

by ipappas on Sat Jun 20, 2015 05:08 PM
Quote | ReplyYes, thanks for sharing the info.

By the way, Howard, we haven't heard from you since a long while. I hope you are doing better. Any news?
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### RE: where to get 3bp and in what form for oral use?

by Danielus on Sat Jun 20, 2015 06:52 PM
Quote | ReplyHoward took an overdose of Salinomycin.
Quote | Reply

### RE: where to get 3bp and in what form for oral use?

by kcervantes on Sat Jun 20, 2015 07:10 PM
Quote | ReplyI'm sure the amount you use daily or weekly has a lot to do with it as well.Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitter Danielus

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### RE: where to get 3bp and in what form for oral use?

by Danielus on Sat Jun 20, 2015 07:16 PM
Quote | Replyso now we have two MDs who are both saying that 3BP shoul not be used and on the other hand we have two clear PUBLISHED case reports + huge number of scienfific articles supporting 3BP + many clinics using 3BP with at least some succeses. Yes, withouth clinical studies is difficult to see overnight a lot of success stories. Working latitute of 3BP is very limitted due to its limitted stability and due to this it takes time to find a working point that worjs for all.

I see no reason why 3BP would create resistance. There is no scientific fundament to such a statement. Yes, 3BP will not kill the cancer cells that arerelying only on glutamine, if that is the case, but Salinomycin will do that.

Finally, note tHat the combi of Anti PDL1 and Dentritic Cells is something that I like but woul only try if there is nothing else that works. Why? Because there is a good chance to trigger a auto immune action which can lead to death of the patient.

Finally, we have to be carefull here with conclusions since in time we will get around doctors that will try to change  our oppinion on 3BP and switch bac to their expensive treatments. For example ANTI PDL1 + Dentritic Cells one round of vaccine will cost about 10k euro Vs 3BP that can be done at home with very limitted cost.

So far, 3BP is one of the most relevant anticancer element and the science behind and published case reports prove that.
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### RE: where to get 3bp and in what form for oral use?

by kcervantes on Sat Jun 20, 2015 07:20 PM
Quote | ReplyDaniel - I completely agree with your statement.Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitter Moonlitnight

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### RE: where to get 3bp and in what form for oral use?

by Moonlitnight on Sat Jun 20, 2015 07:46 PM

Quote | Reply

On Jun 20, 2015 11:16 PM Danielus wrote:

so now we have two MDs who are both saying that 3BP shoul not be used and on the other hand we have two clear PUBLISHED case reports + huge number of scienfific articles supporting 3BP + many clinics using 3BP with at least some succeses. Yes, withouth clinical studies is difficult to see overnight a lot of success stories. Working latitute of 3BP is very limitted due to its limitted stability and due to this it takes time to find a working point that worjs for all.

I see no reason why 3BP would create resistance. There is no scientific fundament to such a statement. Yes, 3BP will not kill the cancer cells that arerelying only on glutamine, if that is the case, but Salinomycin will do that.

Finally, note tHat the combi of Anti PDL1 and Dentritic Cells is something that I like but woul only try if there is nothing else that works. Why? Because there is a good chance to trigger a auto immune action which can lead to death of the patient.

Finally, we have to be carefull here with conclusions since in time we will get around doctors that will try to change  our oppinion on 3BP and switch bac to their expensive treatments. For example ANTI PDL1 + Dentritic Cells one round of vaccine will cost about 10k euro Vs 3BP that can be done at home with very limitted cost.

So far, 3BP is one of the most relevant anticancer element and the science behind and published case reports prove that.
I am guessing these two doctors have either observed or read about lysis in people with a large tumour mass. They used to work together and now they appear to be agreeing that "3BP is dangerous" (or can be under certain circumstances). So is cancer - under ALL circumstances.
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### RE: where to get 3bp and in what form for oral use?

by Jcancom on Sat Jun 20, 2015 08:00 PM
Quote | ReplyThe one thing that I do not understand about the whole narrative that these doctors are on side with mainstream treatment options is that from last we heard from the headlines almost a year ago they had departed for Bogata to treat terminally ill cancer patients with salinomycin and 3-BP. The news release also mentions a miraculous treatment result in which a terminally ill stage IV lung cancer patient was successfully treated. This is the storyline you would have if you used a search engine.

If these doctors were intent on scuttling 3-BP, then why have not they been more prominent, perhaps sent out their own news releases? The only reason that we have found out about their disenchantment  with 3-BP is because we have been in direct contact with both of these doctors!

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### RE: where to get 3bp and in what form for oral use?

by jetsparkle on Sat Jun 20, 2015 08:16 PM

Quote | Reply

On Jun 20, 2015 11:46 PM Moonlitnight wrote:

On Jun 20, 2015 11:16 PM Danielus wrote:

so now we have two MDs who are both saying that 3BP shoul not be used and on the other hand we have two clear PUBLISHED case reports + huge number of scienfific articles supporting 3BP + many clinics using 3BP with at least some succeses. Yes, withouth clinical studies is difficult to see overnight a lot of success stories. Working latitute of 3BP is very limitted due to its limitted stability and due to this it takes time to find a working point that worjs for all.

I see no reason why 3BP would create resistance. There is no scientific fundament to such a statement. Yes, 3BP will not kill the cancer cells that arerelying only on glutamine, if that is the case, but Salinomycin will do that.

Finally, note tHat the combi of Anti PDL1 and Dentritic Cells is something that I like but woul only try if there is nothing else that works. Why? Because there is a good chance to trigger a auto immune action which can lead to death of the patient.

Finally, we have to be carefull here with conclusions since in time we will get around doctors that will try to change  our oppinion on 3BP and switch bac to their expensive treatments. For example ANTI PDL1 + Dentritic Cells one round of vaccine will cost about 10k euro Vs 3BP that can be done at home with very limitted cost.

So far, 3BP is one of the most relevant anticancer element and the science behind and published case reports prove that.
I am guessing these two doctors have either observed or read about lysis in people with a large tumour mass. They used to work together and now they appear to be agreeing that "3BP is dangerous" (or can be under certain circumstances). So is cancer - under ALL circumstances.
Daniel's comment makes a great deal of sense to me--as do all of the other following, supportive comments.

And we have to remember that these doctors that have used 3-BP must be very careful of what they do and what they say--they could lose their licenses as they, no doubt, are being observed by "higher authorities"--  as they attempt to go "outside of the box", so to speak.  However, they are walking on eggshells--and under a microscope.

Any drug that has  current approval seems not to have any problems being used --despite some resulting in horrific side effects.  That is not what we are seeking though--we are trying to brainstorm something that is not as toxic--or not toxic at all--in order to preserve our lives.  We would like quality of life along with quantity of life.

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### RE: where to get 3bp and in what form for oral use?

by Jcancom on Sat Jun 20, 2015 08:24 PM
Quote | ReplyPatent expiration on Yervoy is 2020 in the EU and 2022 in the US. That is starting to get close.

It might have been best if 3-BP had been given full patent protection. The pharma companies could have charged whatever they wanted. If this had happened, we would probably not be still without a single clinical trial with 3-BP in progress. 3-BP might have already been off patent by now!
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### RE: where to get 3bp and in what form for oral use?

by Jcancom on Sun Jun 21, 2015 12:02 PM
Quote | ReplyThere are a few interesting points from the doctor's email that we did not pick up on during our response.

For example, a paraphrase from the doctor "it [3-BP] kills tumors but if complete eradication is not acheived ...". This actually sounds quite positive. It appears that the doctor has achieved near complete eradication in tumors!!! For a patient with near terminal stage cancer that would likely be a better outcome than would be expected with any of their current treatments. These patients could at least then be given a window of near cancer life.

After achieving such a response maintenance doses of 3-BP or other anti-cancer drugs could be applied to prevent recurrence. (Immunotherapy would also be an option.)

The second part of the paraphrase is not so positive "they come back much more aggressively".  This is difficult to understand. In the entire massive tumor mass of the liver cancer patient with 3-BP treatment for almost a year not a single cancer cell became resistant to 3-BP. This was shown because at final analysis the labs were unable to find any surviving cancer cells.

The problem with the cancer returning aggressively might be related to the next paraphrase: "the treatments generally make the patients so sick that they skip the next round which causes the tumors to come back aggressively ...". The first part of the statement is also difficult to understand. 3-BP made the published patients feel better almost immediately. The only side effect that emerged was TLS. This occurred because the doctors had no other patients that they could use as a reference. After the first incident of TLS occurred, the 3-BP treatment was less aggressive and there were no further recurrences of TLS problems during the next almost year of treatment.

It is quite clear, though, that not continuing 3-BP treatment would cause the tumors to return.

It should also be understood that TLS with current best medical practices is highly manageable. Up till now solid tumors have been assigned a low risk of TLS. In fact, one of the few ever reported instances of TLS in colorectal cancer was published in 2008. Of course it should be understood that we might now be in a different era of treatment with drugs such as 3-BP. The TLS studies quoted in the supplement were largely before new powerful anti-cancer had entered the clinic.

With appropriate medical care TLS can be managed.

"in many countries, patients with a bulky Burkitt’s lymphoma who have a high potential for lysis have a low risk of clinical tumor lysis syndrome because they routinely receive aggressive treatment with hydration and rasburicase, a recombinant urate oxidase enzyme that is a highly effective uricolytic agent"

Further with the next generation drug rasburicase, the rate of required dialysis for TLS treatment has been reduced to a few percent (from 9-41% using earlier drugs) and the mortality rate from TLS has been reduced to close to 0% (from up to 10% of those with TLS as reported in the supplement figure). See supplement pdf for the below url for more information.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437249/#SD2

In almost all of these reports the patients had hematologic malignancies that would be suspectible to rapid destruction with treatment. Such a massive tumor destruction in a very short time interval is what causes TLS. However, if 3-BP were used over a period of months to reduce tumor masses, TLS should not then emerge. It only emerged with the liver patient because they treated aggressively with high doses of 3-BP dosed closely together.

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### RE: where to get 3bp and in what form for oral use?

by jetsparkle on Sun Jun 21, 2015 12:48 PM

Quote | Reply

On Jun 21, 2015 12:24 AM Jcancom wrote:

Patent expiration on Yervoy is 2020 in the EU and 2022 in the US. That is starting to get close.

It might have been best if 3-BP had been given full patent protection. The pharma companies could have charged whatever they wanted. If this had happened, we would probably not be still without a single clinical trial with 3-BP in progress. 3-BP might have already been off patent by now!
There was an article about cancer immunotherapies by The Motley Fool today on Yahoo!

Stated that both Keytruda and Yervoy cost approximately $150,000 EACH for immunotherapy treatment.  So treatment costs for both would be at least $300,000 for patients!!!

Good grief....in more ways than one!

I just do not understand--these drugs have so many highly serious side effects--yet they are promoted and given to patients.  And then we hear about the "dangers" of 3-BP--just how bad are they compared to the "accepted" drugs?  Something is rotten in Denmark.....

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### RE: where to get 3bp and in what form for oral use?

by Moonlitnight on Sun Jun 21, 2015 01:14 PM

Quote | Reply

On Jun 21, 2015 4:48 PM jetsparkle wrote:

On Jun 21, 2015 12:24 AM Jcancom wrote:

Patent expiration on Yervoy is 2020 in the EU and 2022 in the US. That is starting to get close.

It might have been best if 3-BP had been given full patent protection. The pharma companies could have charged whatever they wanted. If this had happened, we would probably not be still without a single clinical trial with 3-BP in progress. 3-BP might have already been off patent by now!
There was an article about cancer immunotherapies by The Motley Fool today on Yahoo!

Stated that both Keytruda and Yervoy cost approximately $150,000 EACH for immunotherapy treatment.  So treatment costs for both would be at least $300,000 for patients!!!

Good grief....in more ways than one!

I just do not understand--these drugs have so many highly serious side effects--yet they are promoted and given to patients.  And then we hear about the "dangers" of 3-BP--just how bad are they compared to the "accepted" drugs?  Something is rotten in Denmark.....

The something rotten in Denmark is called Big Pharma profits. Did you see the "60 Minutes" where they determined the ACTUAL cost of cancer drugs? It was a minute fraction of what they charge, purportedly to "recoup trial costs." However, those numbers revealed enormous, obscene profits for the shareholders. Profiting from misery is the lowest form of wealth accumulation imo. We cannot get immunotherapies up here unless we fork out $300,000 or so (Provenge). It's utterly ridiculous and disheartening.
Quote | Reply

### RE: where to get 3bp and in what form for oral use?

by jetsparkle on Sun Jun 21, 2015 02:56 PM

Quote | Reply

On Jun 21, 2015 5:14 PM Moonlitnight wrote:

On Jun 21, 2015 4:48 PM jetsparkle wrote:

On Jun 21, 2015 12:24 AM Jcancom wrote:

Patent expiration on Yervoy is 2020 in the EU and 2022 in the US. That is starting to get close.

It might have been best if 3-BP had been given full patent protection. The pharma companies could have charged whatever they wanted. If this had happened, we would probably not be still without a single clinical trial with 3-BP in progress. 3-BP might have already been off patent by now!
There was an article about cancer immunotherapies by The Motley Fool today on Yahoo!

Stated that both Keytruda and Yervoy cost approximately $150,000 EACH for immunotherapy treatment.  So treatment costs for both would be at least $300,000 for patients!!!

Good grief....in more ways than one!

I just do not understand--these drugs have so many highly serious side effects--yet they are promoted and given to patients.  And then we hear about the "dangers" of 3-BP--just how bad are they compared to the "accepted" drugs?  Something is rotten in Denmark.....
The something rotten in Denmark is called Big Pharma profits. Did you see the "60 Minutes" where they determined the ACTUAL cost of cancer drugs? It was a minute fraction of what they charge, purportedly to "recoup trial costs." However, those numbers revealed enormous, obscene profits for the shareholders. Profiting from misery is the lowest form of wealth accumulation imo. We cannot get immunotherapies up here unless we fork out $300,000 or so (Provenge). It's utterly ridiculous and disheartening.
Well-expressed and written--in total agreement with your thoughts and insights.

And I am sure those involved in this thread feel the same.  I am very grateful for all of the support and intelligent comments/research provided by those with good hearts and motives on this thread.
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### RE: where to get 3bp and in what form for oral use?

by Jcancom on Sun Jun 21, 2015 03:39 PM
Quote | Reply"The planned Phase I study will evaluate the dosing regimen of the drug to determine the maximum tolerated dose (“MTD”)."

http://presciencelabs.com/cancer-treatment-progress/ind-appl

Does not this seem an odd idea for the clinical trial? There seems to be no reason to determine what the maximum tolerated dose is for 3-BP? Determining the maximum tolerated dose for an inhibitor of cellular respiration could result in fatal outcomes. It is already known that very modest amounts of 3-BP in the range of 1-2 mg/kg can have massive anti-tumor effects. Why would determining maximum tolerated dose be relevant? All that people are really interested in is minimum effective dose.
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### RE: where to get 3bp and in what form for oral use?

by Meech90 on Sun Jun 21, 2015 03:42 PM
Quote | ReplyIt's the way clinical trial staging is set up. I believe Phase I is always determining safe dosages.
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### RE: where to get 3bp and in what form for oral use?

by Jcancom on Sun Jun 21, 2015 04:41 PM
Quote | ReplyYes, that is true.

However, with 3-BP it has already been shown to be overwhelmingly effective in the dosage range near 1-2 mg/kg. There seems to be no great reason to do a full dosing study.

All that really is important to patients is to receive treatment with the minimum effective dosage. All that needs to be done is to demonstrate that 3-BP is safe in the dosage range that has already been determined to be effective for cancer treatment. Would the FDA really allow cancer patients to be put at risk merely to answer a question of only theoretical interest?

In some of 3-BP research confusion arose when it was found that 3-BP is quite dangerous when given at higher doses. However, this is completely obvious. Giving an inhibitor of cellular respiration at high doses would be extremely dangerous. Some people mistakenly interpreted this to mean that 3-BP is dangerous when given at the indicated doses for cancer. This has not been shown in current clinical experience.
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### RE: where to get 3bp and in what form for oral use?

by Jcancom on Sun Jun 21, 2015 05:03 PM
Quote | ReplyWhat I was especially interested in with the comment on Yervoy is that it will be off patent in 5 years in the EU!

It might cost $100,000 plus now for a treatment round for it (along with several other new generation immunotherapy products), though they will be off-patent fairly soon now. It will be very interesting to see what their generic pricing will be. It should be marginal cost which might be almost nothing.

It should be understood by those on the thread that we are now approaching a time in the not too distant future where effective anti-cancer medicines will be priced generically!!!

If 3-BP had had some path to these big money prices we might not now be still waiting. Strangely, even in a generic price environment people might still be willing to pay a premium for 3-BP treatment, even though it has yet to undergo clinical trials or been approved by regulators. The currently approved medications are moderately effective, though there are safety concerns. What were to happen if it could be shown that 3-BP is highly effective and without side-effects.

Could a drug that might never be approved by the regulatory process be priced at a premium to those products that had been through the process?
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### RE: where to get 3bp and in what form for oral use?

by Moonlitnight on Sun Jun 21, 2015 05:26 PM

Quote | Reply

On Jun 21, 2015 7:42 PM Meech90 wrote:

It's the way clinical trial staging is set up. I believe Phase I is always determining safe dosages.
It is...
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### RE: where to get 3bp and in what form for oral use?

by Moonlitnight on Sun Jun 21, 2015 05:29 PM

Quote | Reply

On Jun 21, 2015 9:26 PM Moonlitnight wrote:

On Jun 21, 2015 7:42 PM Meech90 wrote:

It's the way clinical trial staging is set up. I believe Phase I is always determining safe dosages.
It is...
Clicked too soon. Phase 1 in non-cancer drugs tends to be phase 2 in cancer drugs, since phase 1 is normally carried out on healthy volunteers.
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### RE: where to get 3bp and in what form for oral use?

by Genelle on Sun Jun 21, 2015 09:17 PM
Quote | ReplyWould coffee enemas detox the TLS?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Mon Jun 22, 2015 11:39 AM
Quote | ReplyGenelle from the thread wanted me to post the results of her PET Scan...
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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Mon Jun 22, 2015 11:41 AM
Quote | ReplyHmmm...But it didnt work :/
Quote | Reply

### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Mon Jun 22, 2015 11:50 AM
Quote | ReplyHere it is again..
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Mon Jun 22, 2015 02:08 PM
Quote | Replyjaycancom

One paper analyzes the gene profiles of the laser-captured connective
tissue, associated with lethal tumors, in human breast cancer patients.
In this paper, lethal cancers show the same gene expression pattern
associated with normal aging, as well as Alzheimer's disease. In fact,
these aging and Alzheimer's disease signatures can identify which breast
cancer patients will undergo metastasis. The researchers find that
oxidative stress is a common "driver" for both dementia and cancer cell
spreading.

https://groups.google.com/forum/#!topic/sci.life-extension/s
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Tue Jun 23, 2015 11:39 AM
Quote | ReplyAt Walmart any suggestions for a nebulizer for 3BP?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Tue Jun 23, 2015 12:59 PM
Quote | ReplyMany on this thread (including me) have wondered why 3-BP has not been more widely adopted by cancer patients. There are few if any other cancer treatments that have ever shown responses similar to that achieved by the liver cancer patient considering his life expectancy was measured in at most months.

I think I am beginning to understand why the uptake has been so slow. I have been posting messages on this forum and others about the benefits of 3-Bromopyruvate. Most of the comments have been along the lines of the truly salacious "Might consider 3-Bromopyruvate." Almost all of these comments have been purged from this forum and most of the others I have posted to. It is extraordinarily sad that the patients that I have tried to alert about 3-BP have almost untreatable cancers. Their doctors have no viable treatment options to offer them: bile duct cancer, liver cancer, pancreatic cancer ...

It is hard to imagine that 3-Bromopyruvate would not at least be something these patients could be made aware of. At the same time this forum and others have entire threads of treatments that have no published scientific evidence to back claims of efficacy.

It is very sad that many forums appear unwilling to even allow cancer patients to decide for themselves about 3-BP.

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Tue Jun 23, 2015 01:11 PM

Quote | Reply

On Jun 23, 2015 4:59 PM Jcancom wrote:

Many on this thread (including me) have wondered why 3-BP has not been more widely adopted by cancer patients. There are few if any other cancer treatments that have ever shown responses similar to that achieved by the liver cancer patient considering his life expectancy was measured in at most months.

I think I am beginning to understand why the uptake has been so slow. I have been posting messages on this forum and others about the benefits of 3-Bromopyruvate. Most of the comments have been along the lines of the truly salacious "Might consider 3-Bromopyruvate." Almost all of these comments have been purged from this forum and most of the others I have posted to. It is extraordinarily sad that the patients that I have tried to alert about 3-BP have almost untreatable cancers. Their doctors have no viable treatment options to offer them: bile duct cancer, liver cancer, pancreatic cancer ...

It is hard to imagine that 3-Bromopyruvate would not at least be something these patients could be made aware of. At the same time this forum and others have entire threads of treatments that have no published scientific evidence to back claims of efficacy.

It is very sad that many forums appear unwilling to even allow cancer patients to decide for themselves about 3-BP.

Really? Well, we are planning on getting it and trying to figure out where. This is through reading the book and doing the research OURSELVES. It will be interesting to see if this comment is purged.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Tue Jun 23, 2015 01:25 PM
Quote | ReplySarting 3BP soon.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Tue Jun 23, 2015 01:39 PM
Quote | Reply{I think that it just so subversive to do what they do not want you to do. What if they know best? (If they did, why don't they speak in complete sentences instead of just deleting ideas they find disturbing?) }

Yes, so many of the other comments have been wiped clean memory. The past can always be rewritten or just deleted. Orwell made some very pertinent comments about censorship that would apply in this circumstance.

Hoperfully, readers on this thread will realize that one possible (though not necessarily correct) interpretation of this behavior is that there truly are people who are intent on suppressing 3-BP as a treatment choice.

3-Bromopyruvate is now the unspeakable word. It is very very sad. 3-Bromopyruvate does not fit into any legitimate category of censorship. It does not discriminate on the basis of race, gender, nationality, age, lifestyle preferences,    socio-economic status.... The only one I can think of is that it does discriminate on the basis of metastatic cancer diagnosis.

Since I have already been banned on most of the other cancer forums I will throw it out to the rest of you to go out to these forums and start the converstation about 3-Bromopyruvate.

We are preaching to the chorus on this forum. Just be careful. Make a comment and just let it sit out there for a while. Most of the forums do not appear to appreciate multiple 3-BP postings. It appears they want to manage the spread of 3-BP on their forums.

It is diappointing that even on this forum many of the posters seem stuck on their own thread and have no recognition of 3-BP. Many of these patients are completely desperate. No one-- their doctors, their families (NO ONE!)-- has any idea what do about their end stage pancreatic cancer, bile duct    cancer, liver cancer...

The most common advice seems to be get your affairs in order. It is so sad.

For many of these people 3-BP would not be a bad choice. If I were in their situation, I would try 3-BP.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Freyr on Tue Jun 23, 2015 02:54 PM
Quote | ReplyDoes 3bp work on brain mets?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Tue Jun 23, 2015 03:02 PM
Quote | ReplyDayspring provides evidence that suggests 3-BP might cross the BBB.

http://www.dayspringcancerclinic.com/why-3bp/

However, it should be noted that no mention of brain mets was mentioned in either the liver cancer patient nor the melanoma patient.

It is very unclear whether 3-BP would be effective with brain mets.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Wed Jun 24, 2015 10:21 AM
Quote | ReplyI have emailed the Tto doc. again as he seems to be the sole one to answer. No staff? Phones never answered. I asked (since the website mentions hotels nearby) if there were any long-term stays such as he suggested to me in our preliminary phone conversation. I find this all very puzzling. I see someone from our own UBC was involved in a veterinary study on 3-BP. I will contact her on Linked in and see if she knows if anyone this side of the country is offering it. Vancouver is usually the leader in underground medical activities :)
Quote | Reply

### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Wed Jun 24, 2015 10:48 AM
Quote | Replycould you site the vet study? My friend a vet would like to see it.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jun 24, 2015 12:20 PM
Quote | ReplyWonder if the animal formulation would be higher quality than what could currently be purchased for human use. Animal welfare treatment guidelines might exceed chemical house standards.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jun 24, 2015 04:50 PM
Quote | ReplyI have a question that I want to pose to the thread.

With bile duct cancer could a surgeon cut off bile flow and then inject 3-BP into the bile duct? It would sort of like a TACE procedure, though instead of stopping blood flow in a blood vessel one would stop bile flow in the bile duct. After the procedure, would there be some way of retrieving the unused 3-BP or diluting it somehow (perhaps one would not want 3-BP to remain in the bile duct)?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Wed Jun 24, 2015 07:57 PM

Quote | Reply

On Jun 23, 2015 6:54 PM Freyr wrote:

Does 3bp work on brain mets?
It seems to work and enhanced by starvation. Dyaspring clinic has the relevant references to support that.

Freyr, I answered you private msg. Did you received that?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Wed Jun 24, 2015 08:03 PM

Quote | Reply

On Jun 24, 2015 2:48 PM Genelle wrote:

could you site the vet study? My friend a vet would like to see it.
Hi Genelle. I think I'm losing it. I have spent two hours looking through all the sites I visited yesterday to do with 3-BP and I cannot for the life of me find this study.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Wed Jun 24, 2015 08:05 PM
Quote | ReplyOH well if you find it my friend has animals with cancer and would like to see it
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Wed Jun 24, 2015 09:27 PM
Quote | ReplyI am not sure it related to veterinary science. I believed it was done in the department of veterninary science but it could have been on yeast for all I know. I will keep searching.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jun 24, 2015 11:01 PM
Quote | ReplyHello everyone. I wanted to point out to everyone a fairly extreme example of the editting that has been happening on this forum.

A poster's mother on this thread

http://www.cancercompass.com/message-board/message/all,85071

is coping with very severe bile duct cancer. At this stage and location of illness treatment options are quite limited. My first response to the poster was something very similar to "Might want to try 3-Bromopyruvte". Surprisingly this common was deleted. However, it is obvious that it has been deleted because the poster's second comment on the thread is thanking me for suggesting it. Another poster joins the conversation and then forcefully advocates a euthanasia approach while disregarding all evidence regarding 3-BP. None of these comments were considered in any way objectionable.

If posters on this thread are so inclined they might post to the bile duct thread noted above.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Wed Jun 24, 2015 11:57 PM

Quote | Reply

On Jun 25, 2015 3:01 AM Jcancom wrote:

Hello everyone. I wanted to point out to everyone a fairly extreme example of the editting that has been happening on this forum.

A poster's mother on this thread

http://www.cancercompass.com/message-board/message/all,85071 ,1.htm?mid=623831#623831"" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071

is coping with very severe bile duct cancer. At this stage and location of illness treatment options are quite limited. My first response to the poster was something very similar to "Might want to try 3-Bromopyruvte". Surprisingly this common was deleted. However, it is obvious that it has been deleted because the poster's second comment on the thread is thanking me for suggesting it. Another poster joins the conversation and then forcefully advocates a euthanasia approach while disregarding all evidence regarding 3-BP. None of these comments were considered in any way objectionable.

If posters on this thread are so inclined they might post to the bile duct thread noted above.
Jcancon,

Just want you to know that I do believe that all of us here on this thread deeply appreciate your advocacy and zeal regarding 3-BP.

Keep up the fine work on behalf of all those who possibly do not have the energy to do the research and become as knowledgeable as you are about this vital topic.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Thu Jun 25, 2015 01:48 AM

Quote | Reply

On Jun 25, 2015 3:57 AM jetsparkle wrote:

On Jun 25, 2015 3:01 AM Jcancom wrote:

Hello everyone. I wanted to point out to everyone a fairly extreme example of the editting that has been happening on this forum.

A poster's mother on this thread

http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  ,1.htm?mid=623831#623831"" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071 "" target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071  target="\_blank" rel="nofollow">http://www.cancercompass.com/message-board/message/all,85071

is coping with very severe bile duct cancer. At this stage and location of illness treatment options are quite limited. My first response to the poster was something very similar to "Might want to try 3-Bromopyruvte". Surprisingly this common was deleted. However, it is obvious that it has been deleted because the poster's second comment on the thread is thanking me for suggesting it. Another poster joins the conversation and then forcefully advocates a euthanasia approach while disregarding all evidence regarding 3-BP. None of these comments were considered in any way objectionable.

If posters on this thread are so inclined they might post to the bile duct thread noted above.
Jcancon,

Just want you to know that I do believe that all of us here on this thread deeply appreciate your advocacy and zeal regarding 3-BP.

Keep up the fine work on behalf of all those who possibly do not have the energy to do the research and become as knowledgeable as you are about this vital topic.
I just get a 401 error message.
Quote | Reply

### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Thu Jun 25, 2015 03:08 AM
Quote | ReplyDitto--no longer there...
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Karantu on Thu Jun 25, 2015 06:26 AM
Quote | ReplyHello all,

I am trying to follow this thread but the amount of information is too much (already 135 pages) and my English is not good enough to understand all.

I have a question;

You mentioned before that 3BP treatment can be done at home (IV, oral, topical or nebulized), it means that it is easy to reach 3BP. I wonder where are the possible places to order 3BP and how to start using it?

Is there any practical step by step information/document on how to start using it? If not, can we (you) start preparing such thing for people like me?

K.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Thu Jun 25, 2015 06:41 AM

Quote | Reply

On Jun 25, 2015 10:26 AM Karantu wrote:

Hello all,

I am trying to follow this thread but the amount of information is too much (already 135 pages) and my English is not good enough to understand all.

I have a question;

You mentioned before that 3BP treatment can be done at home (IV, oral, topical or nebulized), it means that it is easy to reach 3BP. I wonder where are the possible places to order 3BP and how to start using it?

Is there any practical step by step information/document on how to start using it? If not, can we (you) start preparing such thing for people like me?

K.
Hi, I intend to prepare such a document soon. Until that point if is difficult to find the info here I am sharing what I know by private msg. so you can contact me.

Before that you need to get your 3BP. You can get that from Chemical companies such as Sigma Aldrich but you will need to oredr on a company/firm/university address since is sold for research and not for human use. If you canot oredr like this find a friend who is a student or works at university or has a firm so they can order it for you. If that is not possible than you need to oredr from China. For this you can contact me on private and will send you the e-mail address of a few suppliers but try to get it from Sigma since the quality can be 100% trusted. Here is the product you need from Sigma: http://www.sigmaaldrich.com/catalog/product/aldrich/16490?la

You should order about 50g
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Meech90 on Thu Jun 25, 2015 12:21 PM
Quote | ReplyWhat is the capacity of 3BP to attack cancers which show lack of cytoplasm? Glycolysis is mediated by the cytoplasm and as such you'd expect the 3BP molecule to enter cancer cells which have cytoplasm. The problem is that in certain cancers (such as small cell carcinoma), the pathology report will often have "scanty cytoplasm" as a diagnostic hallmark. As far as I know SCLC and EPSCC would still show up positively on a PET scan though.Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterJcancom

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jun 25, 2015 12:31 PM
Quote | ReplyI am not sure I understand. Cellular respiration is an absolute requirement of any living cell in the human body. Cellulular respiration is the only pathway that I am aware of that can provide cells with energy.

Celular respiration must occur somewhere and from what I understand it occurs in the cytoplasm.

The stage IV small cell lung cancer treated in Columbia with 3-BP and salinomycin had a good response to 21 rounds of treatment (post #172 of below url).

http://www.longecity.org/forum/topic/73453-is-3-bromopyruvat

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Meech90 on Thu Jun 25, 2015 01:04 PM
Quote | ReplyAbsolutely it is. But is the cytoplasm responsible for both types of cellular metabolism (oxidative phosphorylation and glycolysis). I know the mitochondrion is responsible for the former but I can't seem to remember whether the mitochondrion is within the cytoplasm or whether it is a separate organelle. A hallmark of certain cancers is the lack of cytoplasm. It is common to note "scanty cytoplasm" within a pathology report for certain cancers. The cytoplasm is responsible for glycolysis so I'd deduce that cancers that lack cytoplasm possibly rely less on glycolysis than other cancers and therefore may have lower sensitivity to 3BP. However, a cancer such as SCLC generally will show scanty cytoplasm, however, it is still PET-sensitive. I think I might just be having a misunderstanding with cellular organelles. It's been a while since my last biology class.Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterDanielus

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Thu Jun 25, 2015 02:44 PM
Quote | ReplyDear Moonlitnight, I am trying to respond to your private msg but somehow Cancer Compass is notiffing me that will not send the msg ... strange ... I tried several times and even changed the msg as I thought there is an error.

Anyway, please send me a msg with your e-mail address and will answer on your e-mail.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Thu Jun 25, 2015 02:55 PM
Quote | ReplyDaniel - can you send that to me as well?Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterkcervantes

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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Thu Jun 25, 2015 02:58 PM
Quote | ReplyNever mind Daniel:) I thought u were responding to Meech90Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterDanielus

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Thu Jun 25, 2015 03:05 PM
Quote | ReplyKim, I will but that will be after my holiday. Anyway you have everything you need so start.
Quote | Reply

### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jun 25, 2015 06:08 PM
Quote | ReplyWell, I have now been banned from most of the world's cancer forums! I received an especially emphatic notification today. Apparently, I have been permantently banned (my IP address recorded), the administrator will not accept my emails... On that board I made a single post to a truly terminal pancreatic cancer patient. I never realized how powerful words could be.

It is especially sad, as it appears that I missed the poster by one day. The poster is now saying no additional treatment will be attempted. If any one could perhaps make a post to the below url with a very subtle hint that 3-BP might be of help to them it might be a real life saver.

http://forum.pancreaticcancer.org.uk/viewtopic.php?t=1640&am

I realize now that the censorship problem we are facing relates to the maturing nature of research into 3-BP. 3-BP has bypassed the normal route to regulatory approval and this has put it into the unproven medicine category. Many of the threads that I have posted to did have some mention of 3-BP, though often it was years out of date. One forum (that I was banned from) was still referring to mouse studies, no mention of human published results. I was almost immediately banned from that forum when I noted that a liver cancer patient and a melanoma had been cured of terminal stage illness with 3-BP. Pushing out of the Alternative threads and into clinical application has many of these forums quite nervous.

I can partially understand this concern. However, this is exactly why I have stayed with the FDA's guidance and suggested people with pancreatic, liver and intrahepatic bile duct cancer consider 3-BP. These patients have virtually no treatment options.

It seems that we are now entering a new Age of Censorship. The internet obviously provides an extraordinarily powerful communications tool: One is able to direct comments to very small populations which would have been almost unreachable before the internet age. If even a handful of the patients with the especially high risk forms of cancer were to attempt 3-BP therapy and if there were even possibly one or two successful outcomes it would not be unexpected that 3-BP could truly go viral. This must be understood by the forums. Thus, there is now a highly restrictive environment concerning 3-BP comments. Ironically the Age of the Internet- due to its extreme power of freely communicating to highly specific populations-- has turned into the Age of Censorship.

It is deeply disturbing. Msot of the patients that we are trying to reach have no available treatment options.

It does not seem reasonable that 3-BP can be withheld from desperate cancer patients indefinitely.

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Thu Jun 25, 2015 06:12 PM

Quote | Reply

On Jun 25, 2015 10:08 PM Jcancom wrote:

Well, I have now been banned from most of the world's cancer forums! I received an especially emphatic notification today. Apparently, I have been permantently banned (my IP address recorded), the administrator will not accept my emails... On that board I made a single post to a truly terminal pancreatic cancer patient. I never realized how powerful words could be.

It is especially sad, as it appears that I missed the poster by one day. The poster is now saying no additional treatment will be attempted. If any one could perhaps make a post to the below url with a very subtle hint that 3-BP might be of help to them it might be a real life saver.

http://forum.pancreaticcancer.org.uk/viewtopic.php?t=1640&f=  target="\_blank" rel="nofollow">http://forum.pancreaticcancer.org.uk/viewtopic.php?t=1640&am

I realize now that the censorship problem we are facing relates to the maturing nature of research into 3-BP. 3-BP has bypassed the normal route to regulatory approval and this has put it into the unproven medicine category. Many of the threads that I have posted to did have some mention of 3-BP, though often it was years out of date. One forum (that I was banned from) was still referring to mouse studies, no mention of human published results. I was almost immediately banned from that forum when I noted that a liver cancer patient and a melanoma had been cured of terminal stage illness with 3-BP. Pushing out of the Alternative threads and into clinical application has many of these forums quite nervous.

I can partially understand this concern. However, this is exactly why I have stayed with the FDA's guidance and suggested people with pancreatic, liver and intrahepatic bile duct cancer consider 3-BP. These patients have virtually no treatment options.

It seems that we are now entering a new Age of Censorship. The internet obviously provides an extraordinarily powerful communications tool: One is able to direct comments to very small populations which would have been almost unreachable before the internet age. If even a handful of the patients with the especially high risk forms of cancer were to attempt 3-BP therapy and if there were even possibly one or two successful outcomes it would not be unexpected that 3-BP could truly go viral. This must be understood by the forums. Thus, there is now a highly restrictive environment concerning 3-BP comments. Ironically the Age of the Internet- due to its extreme power of freely communicating to highly specific populations-- has turned into the Age of Censorship.

It is deeply disturbing. Msot of the patients that we are trying to reach have no available treatment options.

It does not seem reasonable that 3-BP can be withheld from desperate cancer patients indefinitely.

Perhaps the mods think "3-BP" is a new MLM program.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jun 25, 2015 06:15 PM
Quote | ReplyAre there people truly depraved enough to exploit terminally ill cancer patients?

They might be even more worried that it is a new form of NLP.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jun 25, 2015 06:32 PM
Quote | ReplyI think it is all the more appalling because the people have already spoken on this matter. Right to Try Laws have received overwhelming support in America, the United Kingdom and probably elsewhere.

The people have clearly indicated that they will no longer accept "the unproven medicine argument". Many forums appear to be behaving in a manner inconsistent with the current legal reality.

This new legal context might be the reason why there has been such silence about 3-BP treatment results and why the phase 1 trial has been delayed for so long. As soon as a phase 1 trial were to be published or more patient reports were to be published, Right to Try legislation would clearly be in effect (if it is not already).

With the considerable enthusiasm for Right To Try laws and what appears to be extra-legal methods to suppress the democratic process, it might be a good time to start a campaign  for Right to Try II. Patients with truly terminal cancer such as liver cancer, bile duct cancer, pancreatic cancer inter alia with life expectancies of perhaps months should be allowed to access treatments such as 3-BP (when nothing else is considered to have any reasonable chance of success). The problem is that even with the current level of scientific evidence, 3-BP is still likely considered to be in a gray zone of legality.

Terminally ill cancer patients should not have to be put into a situation where they have to treat themselves with 3-BP because it is not legal for doctors to help them.

The people have already spoken clearly on this issue. Perhaps an even clearly respeaking is required.

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Thu Jun 25, 2015 06:51 PM
Quote | ReplyInteresting ... I cannot send private messages anymore. Is it just me or that is the case for all?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Thu Jun 25, 2015 06:53 PM
Quote | ReplyI'm still able to. Looks like we need to go elsewhere with this discussion?Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterJcancom

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jun 25, 2015 06:54 PM
Quote | ReplyThat just happens when you say something you shouldn't!

It happened to me for a while as well. Eventually they let me out of private message prison!

You are likely, for a while they would not let me post to the forum or private message.

We might need to migrate our thread to the wikia if this continues.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Thu Jun 25, 2015 06:57 PM
Quote | ReplyAgreed!Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterjetsparkle

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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Thu Jun 25, 2015 07:08 PM

Quote | Reply

On Jun 25, 2015 10:08 PM Jcancom wrote:

Well, I have now been banned from most of the world's cancer forums! I received an especially emphatic notification today. Apparently, I have been permantently banned (my IP address recorded), the administrator will not accept my emails... On that board I made a single post to a truly terminal pancreatic cancer patient. I never realized how powerful words could be.

It is especially sad, as it appears that I missed the poster by one day. The poster is now saying no additional treatment will be attempted. If any one could perhaps make a post to the below url with a very subtle hint that 3-BP might be of help to them it might be a real life saver.

http://forum.pancreaticcancer.org.uk/viewtopic.php?t=1640&f=  target="\_blank" rel="nofollow">http://forum.pancreaticcancer.org.uk/viewtopic.php?t=1640&am

I realize now that the censorship problem we are facing relates to the maturing nature of research into 3-BP. 3-BP has bypassed the normal route to regulatory approval and this has put it into the unproven medicine category. Many of the threads that I have posted to did have some mention of 3-BP, though often it was years out of date. One forum (that I was banned from) was still referring to mouse studies, no mention of human published results. I was almost immediately banned from that forum when I noted that a liver cancer patient and a melanoma had been cured of terminal stage illness with 3-BP. Pushing out of the Alternative threads and into clinical application has many of these forums quite nervous.

I can partially understand this concern. However, this is exactly why I have stayed with the FDA's guidance and suggested people with pancreatic, liver and intrahepatic bile duct cancer consider 3-BP. These patients have virtually no treatment options.

It seems that we are now entering a new Age of Censorship. The internet obviously provides an extraordinarily powerful communications tool: One is able to direct comments to very small populations which would have been almost unreachable before the internet age. If even a handful of the patients with the especially high risk forms of cancer were to attempt 3-BP therapy and if there were even possibly one or two successful outcomes it would not be unexpected that 3-BP could truly go viral. This must be understood by the forums. Thus, there is now a highly restrictive environment concerning 3-BP comments. Ironically the Age of the Internet- due to its extreme power of freely communicating to highly specific populations-- has turned into the Age of Censorship.

It is deeply disturbing. Msot of the patients that we are trying to reach have no available treatment options.

It does not seem reasonable that 3-BP can be withheld from desperate cancer patients indefinitely.

I cannot even begin to imagine how very frustrated and saddened Drs. Ko and Pedersen must feel about the brick walls they must have run into--and, no doubt, continue to be bedeviled with obstructive behavior from many that are opposed to 3-BP.

What a nightmare for them and for cancer patients.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jun 25, 2015 07:35 PM
Quote | ReplyI think the main point is that if this is about suppression, then the supressors have a very weak hand. This is the reason the censorship has been so extreme. Typically organizations ignore instead of censor. When one censors the obvious question emerges Why?  Removing posts that offer a suggestion for a possibly effective treatment for a terminally ill patient without other options raises (or should) significant concerns.

On most cancer forums you can locate a terminal stage pancreatic / liver / bile duct patient. They have no treatment options. It is a significant overestimate to suggest that such patients have even a 2% chance at surviving 5 years.

Mentioning that  3-BP might help them is very reasonable. It is also quite reasonable to believe that 3-BP truly would help them. The forums seem very apprehensive that a few such untreatable patients might actually try 3-BP. 3-BP would then quickly gain traction.

I find it difficult to imagine that 3-BP can continue to be suppressed. Critical mass has already been achieved. The suppressors are in a very weak position.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jun 25, 2015 08:20 PM
Quote | ReplyWe might quickly be reaching the point where subpoenas will be issued and a full inquiry into the background of 3-BP is conducted. 3-BP has been out in the public domain for quite some time, it has likely reached the point where testimony under could help clear things up. Substantial questions of medical significance could be answered. Considering the urgency of many terminally ill cancer patients it is surprising that such an inquiry has not yet started.

It is interesting to consider how far the 3-BP story has reached into the political, medical and legal spheres of influence.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Meech90 on Thu Jun 25, 2015 10:05 PM
Quote | ReplyI don't think that there's any conspiracy-like malice in deleting the posts. I think that science has become incredibly cult-like. People have so much faith in the current paradigm within the scientific community that they ignore the fact that the scientific paradigm is constantly changing and evolving. It baffles me how people refuse to hear alternative hypotheses on an issue with no firm confirmed answer. They ignore the fact that 60 years ago, exercise was seen as something unhealthy, or countless other scientific principles that were taken as complete fact being disproven. It's a dangerous line of thinking people have gotten into and it's akin to groupthink. The hubris to think that we have the answers. It's an absolute joke that people won't hear other sides on a medical issue that's had no improvement since the 1950s in terms of overall survival and a disease that afflicts 1/3 of all people despite billions of dollars being poured into it. It's infuriating.Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterJcancom

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jun 25, 2015 10:16 PM
Quote | ReplyThank you for the input.

I am struggling to understand the logic that is being used. I would love for the forum to actually to explain their behavior. They could at least indicate what they find objectionable. There would be something to at least discuss.

All I have to work with is their response.

My best guess is that they would argue that providing information on 3-BP is a form of medical advice for a drug that has never been proven to be safe nor effective. In fact, it has of yet not even started a single clinical trial. That is all true. However, the FDA appears to have signalled in 2013 and in 2014 that 3-BP would be a possibility for very difficult to treat cancers.

My suspicion is raised when 3-BP posts are deleted when posters have given up on all treatment. 3-BP for them would seem a reasonable choice.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Thu Jun 25, 2015 10:19 PM

Quote | Reply

On Jun 26, 2015 2:05 AM Meech90 wrote:

I don't think that there's any conspiracy-like malice in deleting the posts. I think that science has become incredibly cult-like. People have so much faith in the current paradigm within the scientific community that they ignore the fact that the scientific paradigm is constantly changing and evolving. It baffles me how people refuse to hear alternative hypotheses on an issue with no firm confirmed answer. They ignore the fact that 60 years ago, exercise was seen as something unhealthy, or countless other scientific principles that were taken as complete fact being disproven. It's a dangerous line of thinking people have gotten into and it's akin to groupthink. The hubris to think that we have the answers. It's an absolute joke that people won't hear other sides on a medical issue that's had no improvement since the 1950s in terms of overall survival and a disease that afflicts 1/3 of all people despite billions of dollars being poured into it. It's infuriating.Oh Meech, you are so right there. What stuns me is that - in the case of prostate cancer at least - there are a certain set of drugs that are "worked through." If you don't respond well to the "last" one, as my guy has not, you are told there is nothing more they can do and so it is now into palliative care/hospice. The nerve! People BELIEVE this and so their bodies shut down. There are always other things to try, like 3-BP which is "dangerous and unproven." Unlike chemo, which is dangerous and proven. I find it utterly, completely unbelievable. We have been summarily dumped by the cancer agency here and now by my husband's oncologist as he refused chemo.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jun 25, 2015 10:31 PM
Quote | ReplyPossibly the most infuriating thing of all is that after 14 years we still do not have definitive answers!

This would just be so easy. Offer patients with absolutely no hope with conventional therapy and see what happens with 3-BP. Answers could be obtained in weeks!

People with terminal liver and bile duct cancer, and pancreatic cancer do not generally recover. Even a few positive reports would have considerable weight. Many doctors have probably never seen a patient with these illnesses ever recover. (Government should probably require a form to be filled out if there were ever such an outcome. We would then have an accurate assessment of how rare recoveries truly are. I would suspect it quite rare, perhaps as few as 1 in an thousand.)
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Meech90 on Thu Jun 25, 2015 10:47 PM

Quote | Reply

On Jun 26, 2015 2:31 AM Jcancom wrote:

Possibly the most infuriating thing of all is that after 14 years we still do not have definitive answers!

This would just be so easy. Offer patients with absolutely no hope with conventional therapy and see what happens with 3-BP. Answers could be obtained in weeks!

People with terminal liver and bile duct cancer, and pancreatic cancer do not generally recover. Even a few positive reports would have considerable weight. Many doctors have probably never seen a patient with these illnesses ever recover. (Government should probably require a form to be filled out if there were ever such an outcome. We would then have an accurate assessment of how rare recoveries truly are. I would suspect it quite rare, perhaps as few as 1 in an thousand.)
I think the problem with 3BP is that clinical trials are generally funded by pharmaceutical companies and it is an extremely simple compound and hard to patent because of it's relative ease in terms of manufacturing. There may not even be a wilfull attempt to suppress 3BP but the fact is that if there is no way to recoup the losses on finding a trial and to profit after said trial, then there really is no incentive for a business to fund the trial. I would assume this is the main reason for why there has been no progress on the 3BP front.Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterJcancom

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jun 25, 2015 10:59 PM
Quote | ReplyI would tend to think there is an attempt being made to suppress this. As I have noted, it really would be fairly easy to prove that 3-BP is actually effective. When you go onto this forum it is easy to locate ideal patients for 3-BP treatment. It would be well within the bounds of morally acceptable treatment.

The tortuously bad logic being used on this forum and many others that it is better that these patients receive no treatment than to receive 3-BP treatment, indicates a desperate attempt to protect commercial interests and not the best interest of patients. Such poor rationality has no particular long term sustainability. It seems desperate. If a more plausible argument cannot be soon advanced, then people who realize that they have been deceived about treatment choices.

We need to remember that it took the Johns Hopkins researchers ten years to even have one published patient -- from Germany.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Thu Jun 25, 2015 11:05 PM

Quote | Reply

On Jun 26, 2015 2:19 AM Moonlitnight wrote:

On Jun 26, 2015 2:05 AM Meech90 wrote:

I don't think that there's any conspiracy-like malice in deleting the posts. I think that science has become incredibly cult-like. People have so much faith in the current paradigm within the scientific community that they ignore the fact that the scientific paradigm is constantly changing and evolving. It baffles me how people refuse to hear alternative hypotheses on an issue with no firm confirmed answer. They ignore the fact that 60 years ago, exercise was seen as something unhealthy, or countless other scientific principles that were taken as complete fact being disproven. It's a dangerous line of thinking people have gotten into and it's akin to groupthink. The hubris to think that we have the answers. It's an absolute joke that people won't hear other sides on a medical issue that's had no improvement since the 1950s in terms of overall survival and a disease that afflicts 1/3 of all people despite billions of dollars being poured into it. It's infuriating.Oh Meech, you are so right there. What stuns me is that - in the case of prostate cancer at least - there are a certain set of drugs that are "worked through." If you don't respond well to the "last" one, as my guy has not, you are told there is nothing more they can do and so it is now into palliative care/hospice. The nerve! People BELIEVE this and so their bodies shut down. There are always other things to try, like 3-BP which is "dangerous and unproven." Unlike chemo, which is dangerous and proven. I find it utterly, completely unbelievable. We have been summarily dumped by the cancer agency here and now by my husband's oncologist as he refused chemo.
I am sorry you and your husband were so mistreated--no one likes to be "dumped" by those who profess to care and heal the sick.  Even when we know they do not have the answers, it is still a psychological blow and stress to be mishandled by others in that way.  It is unconscionable on their part.

There is a Chinese saying (and I may not be getting this just right--but the idea is there):  " You may not be able to prevent the birds of worry from circling around your head--but do not let them nest there"--so just move forward and do not allow their negativity to make any impressions upon you.  Never give up!

All in all, you are headed in a better direction--and I hope that a more helpful and less toxic treatment will be available very soon for your husband.  The wonderful information we have been privileged to receive on this thread about 3-BP is very encouraging to all and gives us hope.

Best to you both and to all here on the thread.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Thu Jun 25, 2015 11:19 PM

Quote | Reply

On Jun 26, 2015 3:05 AM jetsparkle wrote:

On Jun 26, 2015 2:19 AM Moonlitnight wrote:

On Jun 26, 2015 2:05 AM Meech90 wrote:

I don't think that there's any conspiracy-like malice in deleting the posts. I think that science has become incredibly cult-like. People have so much faith in the current paradigm within the scientific community that they ignore the fact that the scientific paradigm is constantly changing and evolving. It baffles me how people refuse to hear alternative hypotheses on an issue with no firm confirmed answer. They ignore the fact that 60 years ago, exercise was seen as something unhealthy, or countless other scientific principles that were taken as complete fact being disproven. It's a dangerous line of thinking people have gotten into and it's akin to groupthink. The hubris to think that we have the answers. It's an absolute joke that people won't hear other sides on a medical issue that's had no improvement since the 1950s in terms of overall survival and a disease that afflicts 1/3 of all people despite billions of dollars being poured into it. It's infuriating.Oh Meech, you are so right there. What stuns me is that - in the case of prostate cancer at least - there are a certain set of drugs that are "worked through." If you don't respond well to the "last" one, as my guy has not, you are told there is nothing more they can do and so it is now into palliative care/hospice. The nerve! People BELIEVE this and so their bodies shut down. There are always other things to try, like 3-BP which is "dangerous and unproven." Unlike chemo, which is dangerous and proven. I find it utterly, completely unbelievable. We have been summarily dumped by the cancer agency here and now by my husband's oncologist as he refused chemo.
I am sorry you and your husband were so mistreated--no one likes to be "dumped" by those who profess to care and heal the sick.  Even when we know they do not have the answers, it is still a psychological blow and stress to be mishandled by others in that way.  It is unconscionable on their part.

There is a Chinese saying (and I may not be getting this just right--but the idea is there):  " You may not be able to prevent the birds of worry from circling around your head--but do not let them nest there"--so just move forward and do not allow their negativity to make any impressions upon you.  Never give up!

All in all, you are headed in a better direction--and I hope that a more helpful and less toxic treatment will be available very soon for your husband.  The wonderful information we have been privileged to receive on this thread about 3-BP is very encouraging to all and gives us hope.

Best to you both and to all here on the thread.
Thank you so much... I love the Chinese saying! Had to look it up and here it is in all its glory:

"That the birds of worry and care fly over your head, this you cannot change, but that they build nests in your hair, this you can prevent."
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Thu Jun 25, 2015 11:32 PM

Quote | Reply

On Jun 26, 2015 3:19 AM Moonlitnight wrote:

On Jun 26, 2015 3:05 AM jetsparkle wrote:

On Jun 26, 2015 2:19 AM Moonlitnight wrote:

On Jun 26, 2015 2:05 AM Meech90 wrote:

I don't think that there's any conspiracy-like malice in deleting the posts. I think that science has become incredibly cult-like. People have so much faith in the current paradigm within the scientific community that they ignore the fact that the scientific paradigm is constantly changing and evolving. It baffles me how people refuse to hear alternative hypotheses on an issue with no firm confirmed answer. They ignore the fact that 60 years ago, exercise was seen as something unhealthy, or countless other scientific principles that were taken as complete fact being disproven. It's a dangerous line of thinking people have gotten into and it's akin to groupthink. The hubris to think that we have the answers. It's an absolute joke that people won't hear other sides on a medical issue that's had no improvement since the 1950s in terms of overall survival and a disease that afflicts 1/3 of all people despite billions of dollars being poured into it. It's infuriating.Oh Meech, you are so right there. What stuns me is that - in the case of prostate cancer at least - there are a certain set of drugs that are "worked through." If you don't respond well to the "last" one, as my guy has not, you are told there is nothing more they can do and so it is now into palliative care/hospice. The nerve! People BELIEVE this and so their bodies shut down. There are always other things to try, like 3-BP which is "dangerous and unproven." Unlike chemo, which is dangerous and proven. I find it utterly, completely unbelievable. We have been summarily dumped by the cancer agency here and now by my husband's oncologist as he refused chemo.
I am sorry you and your husband were so mistreated--no one likes to be "dumped" by those who profess to care and heal the sick.  Even when we know they do not have the answers, it is still a psychological blow and stress to be mishandled by others in that way.  It is unconscionable on their part.

There is a Chinese saying (and I may not be getting this just right--but the idea is there):  " You may not be able to prevent the birds of worry from circling around your head--but do not let them nest there"--so just move forward and do not allow their negativity to make any impressions upon you.  Never give up!

All in all, you are headed in a better direction--and I hope that a more helpful and less toxic treatment will be available very soon for your husband.  The wonderful information we have been privileged to receive on this thread about 3-BP is very encouraging to all and gives us hope.

Best to you both and to all here on the thread.
Thank you so much... I love the Chinese saying! Had to look it up and here it is in all its glory:

"That the birds of worry and care fly over your head, this you cannot change, but that they build nests in your hair, this you can prevent."
And thank you!!  Really love this saying--could only recall the gist of it--glad you re-wrote it properly for us to read.  Such a good reminder as we face our daily challenges!
Quote | Reply

### RE: Anyone used 3bp (3-bromopyruvate)?

by Jagdon on Fri Jun 26, 2015 12:20 AM
Quote | ReplyDear Danielus,

 I did send you a private message.Could  you let me know if you received it.Thanks .
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Karantu on Fri Jun 26, 2015 06:51 AM

Quote | Reply

On Jun 26, 2015 4:20 AM Jagdon wrote:

Dear Danielus,

 I did send you a private message.Could "" target="\_blank" rel="nofollow">http://message.Could " target="\_blank" rel="nofollow">message.Could  you let me know if you received it.Thanks "" target="\_blank" rel="nofollow">http://it.Thanks " target="\_blank" rel="nofollow">it.Thanks  .
Danielus, I also sent you a private message regarding to the usage of 3BP, but I am not sure if its lost somewhere between. :/

Because I can't find it in my private messages. I hope you get it and reply.

Kind regards,

K
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Fri Jun 26, 2015 06:33 PM
Quote | ReplyToday, I succeded to respond again to private msgs / probably was a bug from Cancer Compass? I hope that was the case.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Fri Jun 26, 2015 06:38 PM

Quote | Reply

On Jun 26, 2015 10:33 PM Danielus wrote:

Today, I succeded to respond again to private msgs / probably was a bug from Cancer Compass? I hope that was the case.
...and you are on vacation. Thank you so much for your generosity, Daniel. You are beyond kind.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jagdon on Fri Jun 26, 2015 11:55 PM
Quote | ReplyI got a source of 3 BP.The  price they are quoting is USD per gram of 3BP(purity >97%).Is this right price?Thanks.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jagdon on Fri Jun 26, 2015 11:56 PM
Quote | ReplyI got a source of 3 BP.The price they are quoting is USD 85 per gram of 3BP(purity >97%).Is this right price?Thanks.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Sat Jun 27, 2015 12:40 AM
Quote | ReplyI paid $47 per gram usd. 97% purityQuote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterJcancom

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 27, 2015 01:00 AM
Quote | ReplySigma is the gold standard they charge $100 for 10 grams.

The expert opinion of the thread is to stay with American or European chemical houses. Paying more and getting higher nominal quality from other sources might not mean a better product.

One idea that has been tried is to ask the supplier about the route of synthesis. One supplier would not answer this question on the grounds that they considered this to be proprietary information.

If you could get this information from a supplier, then you might be able to further enhance the purity of the product. For example, 3-BP has a density of about 2.0 g/ml. Thus, it should sink in water. In some synthesis routes for 3-BP one or more of the bi-products should float on water. Thus you could obtain a higher purity product by simply drawing from the bottom of container.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jun 27, 2015 10:05 AM
Quote | ReplyQuestion. The fellow who was going to order my supply from Sigma is saying he doesn't think Sigma is one of their suppliers. My husband is very desperate and needs this now. We even have a professional willing to IV. Has anyone had any success in ordering directly from Sigma, as opposed to getting someone in the business to?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 27, 2015 11:37 AM
Quote | ReplyThere has been trouble ordering directly from Sigma. When they ask for an address to send the 3-BP to they know right away if you are who you say you are.

Other suppliers are more flexible.
Quote | Reply

### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jun 27, 2015 12:03 PM

Quote | Reply

On Jun 27, 2015 3:37 PM Jcancom wrote:

There has been trouble ordering directly from Sigma. When they ask for an address to send the 3-BP to they know right away if you are who you say you are.

Other suppliers are more flexible.
Do you mean in China?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 27, 2015 12:12 PM
Quote | ReplyNo, American/Euorpean.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jun 27, 2015 12:24 PM

Quote | Reply

On Jun 27, 2015 4:12 PM Jcancom wrote:

No, American/Euorpean.
OK. This is one insanely long thread. Does anyone have the names of US suppliers other than Sigma? Scuse any typos. Blinding migraine.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 27, 2015 01:42 PM
Quote | ReplyIf you have access through the front door, then why not try the front door?

That oughta do it:

http://www.chembuyersguide.com/chemical-suppliers/united-sta

Funny Sigma isn't on the list!

Here's Santa Cruz:

http://www.scbt.com/datasheet-260854.html

Remember when searching through their product catalogues to use different synonyms for 3-BP. For example, 1113-59-3,3-Bromopyruvic acid,Bromopyruvate, 3-Bromo-2-oxopropionic acid etc. . Also make sure to double check that you are buying C3H3BrO3.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jagdon on Sat Jun 27, 2015 01:55 PM
Quote | ReplyThe company make of 3 BP is Matrix Scientific.Is  this a relaible source of 3 BP?Thanks.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jun 27, 2015 02:06 PM
Quote | ReplyHow is this powder a "dangerous good (sic) for transport"?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 27, 2015 02:11 PM
Quote | ReplyThere can be no doubt that drugs such as 3-BP are dangerous if not handled with care. The treatment doses used in the published patient reports were in the range of 1-2 mg/kg!

When animals were treated with higher doses there were very serious consequences.

At higher than therapeutic doses, cellular respiration would stop not only in cancer cells but also in healthy cells!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jun 27, 2015 02:16 PM
Quote | ReplyGot you, so one should likely use a respirator when mixing.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 27, 2015 02:17 PM
Quote | ReplyProbably should take specific questions about individual chemical suppliers off thread to private messages or email.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jun 27, 2015 02:17 PM

Quote | Reply

On Jun 27, 2015 6:16 PM Moonlitnight wrote:

Got you, so one should likely use a respirator when mixing.
I mean a full mask, not respirator.
Quote | Reply

### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 27, 2015 02:40 PM
Quote | ReplyI will defer to the experts on the thread.

My best guess would be that a respirator would not be required. A simple hospital mask, though, might be a good idea. It would at least add to the sterile environment you want to create.

The published reports of problems ( with for example, salinomycin) happened when the chemical was directly inhaled from a chemical source.

The main point would be that you do not want to have multi-gram bottles of 3-BP exposed. Perhaps you could remove approximately 50 mg portions from the bottle with a sterile scoop and then reseal the 3-BP.

As long as you are not directly inhaling the 3-BP, it should not spontaneously become aerosoled. I think it would be ideal if you could find some way of creating a completely closed system to avoid contact with 3-BP almost entirely.

For example, if you could remove the 3-BP from the bottle with a syringe and then inject the 3-BP into a sterile enclosed container on the scale through a port. After you had the correct amount of 3-BP you could port in a small amount of saline etc. into the sterile container for mixing.

I have no idea if that really makes sense. I will just leave it to the experts on the thread.

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jun 27, 2015 02:48 PM
Quote | ReplyThanks J. My primary issue is getting it across the border. My shipper will not accept "dangerous goods." So unless the company my friend works for is able to order and accept it, we are kind of stuck. We live across the border from WA, in Vancouver. Any Canucks here who are using it?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 27, 2015 02:56 PM
Quote | ReplyI just tried the syringe idea. Didn't really work out. It is hard to syringe a powder. Trying to do this will just aersol the 3-BP when you push it out which is exactly what you do not want to do!

Probably best to stay with a sterile 50 mg scoop.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Sat Jun 27, 2015 02:59 PM

Quote | Reply

On Jun 27, 2015 6:17 PM Jcancom wrote:

Probably should take specific questions about individual chemical suppliers off thread to private messages or email.
Glad you mentioned this.....vital to keep certain information as this more private-- while  still being able to share with those who are truly  interested in being helped.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 27, 2015 03:12 PM
Quote | ReplyThe Chinese supplier I bought 3-BP through labeled it iron oxide. Canadian customs didn't buy it: They found it difficult to imagine that someone would pay premium shipping charges to transport rust! Amazing that they were able to find the one suspicious package in a whole warehouse of packages!

They were very cool about it, though. The package was opened and went through Canadian regulatory authorities and then they just let it through.

I am really not sure what they  mean by "dangerous good"! Any chemical would likely be considered "dangerous". As long it is bottled and sealed and resealed and reresealed I do see how it could be all that dangerous.

Anyone in Canada who could order through a chemical supplier in the States must have a route to ship. Could always leave it up to the chemical house. Wonder if Canada has only chemical supplier branch plants or home grown companies.

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 27, 2015 06:35 PM
Quote | ReplyHere is the url for the melanoma patient again. Very startling. His LDH level went from 4500 to 12! Essentially a metabolic cure.

http://www.ncbi.nlm.nih.gov/pubmed/24636230

And here is the url for the Dayspring patients.

http://www.dayspringcancerclinic.com/3bp-cases/
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jun 27, 2015 07:18 PM
Quote | ReplyPretty remarkable I'd say...the first one at least.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sat Jun 27, 2015 08:00 PM
Quote | ReplyJcancom, there is no need for a mask when working with 3BP. A sterile scoop would be great but if not available a clean scoop but not sterile is also fine as long as in the end you use sterile filter to sterilize the 3BP solution prepared for IV.

Salinomycin >95% on the other hand would require a mask although I worked with it without a mask with no issues :)
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jun 27, 2015 08:09 PM

Quote | Reply

On Jun 27, 2015 7:12 PM Jcancom wrote:

The Chinese supplier I bought 3-BP through labeled it iron oxide. Canadian customs didn't buy it: They found it difficult to imagine that someone would pay premium shipping charges to transport rust! Amazing that they were able to find the one suspicious package in a whole warehouse of packages!

They were very cool about it, though. The package was opened and went through Canadian regulatory authorities and then they just let it through.

I am really not sure what they  mean by "dangerous good"! Any chemical would likely be considered "dangerous". As long it is bottled and sealed and resealed and reresealed I do see how it could be all that dangerous.

Anyone in Canada who could order through a chemical supplier in the States must have a route to ship. Could always leave it up to the chemical house. Wonder if Canada has only chemical supplier branch plants or home grown companies.

J., when you ordered, did you do so as a researcher/company or just a plain old "person"?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 27, 2015 08:24 PM
Quote | ReplyThe Chinese were pretty lenient. They asked for a company name and I just included the ordering name. I pretended that I did not understand the question. No problems!

I think probably what happened was the Chinese signalled to Canadian customs that there were issues with the package and just handed off the regulatory issues to customs. I do not see how customs could possibly randomly choose a package in a huge warehouse and just hit the jackpot.

I would not use the Chinese product for injection. You really need to stick with a brand name American or European chemical supplier.
Quote | Reply

### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jun 27, 2015 08:51 PM
Quote | ReplyThanks J. I agree that it is not a good idea to inject Chinese products. We are getting onto this Monday.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 27, 2015 09:00 PM
Quote | ReplyI think I found the sterile spoon solution. It might be somewhat overboard, probably not really necessary, though here it is. The spoons would cost you more than the 3-BP!

Even these spoons are giving you too much 3-BP. Filling a 0.05 ml spoon with 3-BP would still be about 100 mg.

http://www.coleparmer.com/Product/Scienceware\_PS\_Sampling\_Sp

I could find only 1 Canadian chemical supplier of 3-BP. I would want to double check that they actually made it (and not just imported it from China).
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jun 27, 2015 09:03 PM
Quote | ReplyBut the website is a US one I believe. That is the place I checked this morning. I will call them Monday.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jun 27, 2015 09:11 PM
Quote | ReplyYes, it is somewhat strange. The only Canadian chemical supplier of 3-BP located in Toronto and asking for orders to be paid in US dollars. I would want to make sure that they are actually making it themselves and not just an importer of Chinese product.

Anyone can just buy Chinese product. What would the point of that be?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jun 27, 2015 09:28 PM

Quote | Reply

On Jun 28, 2015 1:11 AM Jcancom wrote:

Yes, it is somewhat strange. The only Canadian chemical supplier of 3-BP located in Toronto and asking for orders to be paid in US dollars. I would want to make sure that they are actually making it themselves and not just an importer of Chinese product.

Anyone can just buy Chinese product. What would the point of that be?
Convenience.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Meech90 on Sun Jun 28, 2015 12:51 PM
Quote | ReplySince a lot of you seem to have tried it at home, have you seen any success with 3BP?Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterkcervantes

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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Sun Jun 28, 2015 12:55 PM
Quote | ReplyJcancom -

How do we know for sure the US companies arent buying from China??  Is there any way to tell?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Jun 28, 2015 01:35 PM
Quote | ReplyIt ultamately does not matter who actually does the synthesis. I am sure China has very proficient chemists, much of their product likely is high caliber. What is lacking in China is the legal and regulatory environment that would give everyone confidence to intravenously inject 3-BP.

It is not beyond imagination that American companies simply buy high quality 3-BP from China and simply mark it up. They might just put their feet up from there. Yet, the thing to remember is that they were selling products that were not exactly as specified there would be grounds for legal action. This is what you are really buying from American companies.

It will take decades for Chinese companies to establish similar confidence in their products.

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sun Jun 28, 2015 02:30 PM

Quote | Reply

On Jun 28, 2015 4:55 PM kcervantes wrote:

Jcancom -

How do we know for sure the US companies arent buying from China??  Is there any way to tell?
The origination should be on the MSDS. Acros Organics in NJ appears to suppy the ColePalmer company.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Jun 28, 2015 02:40 PM
Quote | ReplyThat's interesting. I looked at the Sigma MSDS for 3-BP. They did not seem to include the synthesis company, though they gave a phone number to call if one wanted information on preparation.

http://www.sigmaaldrich.com/MSDS/MSDS/DisplayMSDSPage.do?cou

Another company selling 3-BP was contacted and was asked for this information. They replied it was proprietary. If you knew how the 3-BP was prepared, then you would know what contaminants were present along with the 3-BP. Perhaps you could do some simple purification steps.
Quote | Reply

### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sun Jun 28, 2015 02:50 PM
Quote | ReplyCould someone please post the sceintific formula again please? There are so many names on the websites, ethyl, methyl, etc.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Jun 28, 2015 02:59 PM
Quote | ReplyBromopyruvic acidSynonyms:3-Bromo-2-oxopropionic acidFormula:C3H3BrO3Molecular Weight:166.96 g/molCAS-No.:1113-59-3EC-No.:214-206-5It is possible that some of the analogs of 3-BP could be even more effective. For example, 3-BrOP. Probably best to stay with a known entity.Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterMoonlitnight

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sun Jun 28, 2015 04:07 PM

Quote | Reply

On Jun 28, 2015 6:59 PM Jcancom wrote:

Bromopyruvic acidSynonyms:3-Bromo-2-oxopropionic acidFormula:C3H3BrO3Molecular Weight:166.96 g/molCAS-No.:1113-59-3EC-No.:214-206-5It is possible that some of the analogs of 3-BP could be even more effective. For example, 3-BrOP. Probably best to stay with a known entity.Thanks J. I have copied, pasted and printed.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sun Jun 28, 2015 04:36 PM
Quote | ReplyBackordered. :(
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sun Jun 28, 2015 04:59 PM
Quote | ReplyHas anyone ordered from Santa Cruz?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Jun 28, 2015 05:50 PM
Quote | Replyhttps://en.wikipedia.org/wiki/Sublingual\_administration
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Mon Jun 29, 2015 06:34 PM
Quote | ReplyThere are so many known aspects that hospitals should take into account when performing treatments in cancer patients ... and unfortunately not used ...

For example the simple depletion of GSH a few days before and during the chemo may enhance the effectivness of chemo so much.

And here is another one: THE IMMUNE CYCLE: The immune cycle repeats itself approximately every 7-days on average. It can be identifyed by measuring CRP level. If the anti-cancer treatments (chemo, immunotheraphy, etc.) are delivered at the righ time/day the effectivness of these treatments can be greaty enhanced: https://en.wikipedia.org/wiki/Immune\_cycle

My suggestion: if you can convince your doctor to measure CRP levels (a low cost test) every two days during 1.5 weeks you should be able to determine you immune cycle and perform your treatments accordingly.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Mon Jun 29, 2015 06:38 PM

Quote | Reply

On Jun 29, 2015 10:34 PM Danielus wrote:

There are so many known aspects that hospitals should take into account when performing treatments in cancer patients ... and unfortunately not used ...

For example the simple depletion of GSH a few days before and during the chemo may enhance the effectivness of chemo so much.

And here is another one: THE IMMUNE CYCLE: The immune cycle repeats itself approximately every 7-days on average. It can be identifyed by measuring CRP level. If the anti-cancer treatments (chemo, immunotheraphy, etc.) are delivered at the righ time/day the effectivness of these treatments can be greaty enhanced: https://en.wikipedia.org/wiki/Immune\_cycle "" target="\_blank" rel="nofollow">https://en.wikipedia.org/wiki/Immune\_cycle " target="\_blank" rel="nofollow">https://en.wikipedia.org/wiki/Immune\_cycle

My suggestion: if you can convince your doctor to measure CRP levels (a low cost test) every two days during 1.5 weeks you should be able to determine you immune cycle and perform your treatments accordingly.
I know some docs give chemo infusions late in the day. ALso, fasting for 24 hours before chemo allows it to work better. Insulin potentiation perhaps?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Mon Jun 29, 2015 06:52 PM
Quote | ReplyCrP measurement could be added with 3-BP treatment to maximize effectiveness?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Mon Jun 29, 2015 06:55 PM
Quote | ReplyThat makes very much sense indeed.
Quote | Reply

### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Mon Jun 29, 2015 07:04 PM
Quote | ReplyResearch has found that CrP is a predictor for response metastatic colorectal cancer patients to first line chemotherapy.

http://www.ncbi.nlm.nih.gov/pubmed/?term=Tumor+markers+CEA+and+CA+19-9+correlate+with+radiological+imaging+in+metastatic+colorectal+cancer+patients+receiving+first-line+chemotherapy

Wonder about time of day (circadian) and ultraradian rhythms effects on 3-BP. Also, wonder what genetic variants might help (e.g. mitochondrial dna).
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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Mon Jun 29, 2015 07:21 PM
Quote | ReplyHow would you suggest using 3BP sublingually?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Mon Jun 29, 2015 07:46 PM

Quote | Reply

On Jun 29, 2015 11:21 PM kcervantes wrote:

How would you suggest using 3BP sublingually?
I was going to ask the same... JH has a "sugar coated pill" that could be sublingual. It would be challenging to find some means of keeping it stable. Maybe there are sublingual melting capsules somewhere...
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Mon Jun 29, 2015 07:50 PM
Quote | ReplyOne of the original Hopkins patents mentions sublingual delivery of 3-BP. It would be a needle-free delivery route (as for example, nebulizing).

I was not sure about formulating it correctly: that is, if pH balancing (with e.g. NaBic) would be necessary.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Mon Jun 29, 2015 07:54 PM
Quote | ReplyJcancom - you're so good at researching:) please do and let us know!Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twittersherlock8603

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### RE: Anyone used 3bp (3-bromopyruvate)?

by sherlock8603 on Mon Jun 29, 2015 07:55 PM
Quote | Replyhas anyone on here gone to www.cancercuremedicine.com

a cancer researcher, Maria Athanassiou has set it up to promote 3 BP.  she is not into alternative.  the website is very informative and needs to be spread around.  i believe there is a facebook link too but i am not on there
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Mon Jun 29, 2015 07:56 PM
Quote | ReplyUm, I think on a matter of such importance one of our more esteemed (and at this time vacationing) members of the thread might offer some insight.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Mon Jun 29, 2015 07:57 PM
Quote | ReplyHaha...A well deserved vacation :)Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterJcancom

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Mon Jun 29, 2015 08:08 PM
Quote | ReplyWelcome aboard new poster!

I am really starting to buy into the idea that we all can make a contribution to move this forward. There are quite a few obstacles with 3-BP treatment that can be overcome with a collective effort.

Things are really starting to get interesting around here. Grab a chair and enjoy the show.

(Yes, some on this thread have posted to we have a cure. This thread is more focused on the hands on treatment side. Working the politico-social side of 3-BP (as the wehaveacure site tries to do) offers significant challenges. It appears that normal channels to move 3-BP forward have been blocked and likely will remain so for the indefinite future.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Mon Jun 29, 2015 08:17 PM
Quote | Replywww.cancercuremedicine.com

This website is very informative
Quote | Reply

### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Mon Jun 29, 2015 08:49 PM

Quote | Reply

On Jun 29, 2015 11:56 PM Jcancom wrote:

Um, I think on a matter of such importance one of our more esteemed (and at this time vacationing) members of the thread might offer some insight.
Sound like some of our dear members have great delegating skils :D

Is too important to stay away even during the holiday :)

I think with 3BP today we have a good idea (yet maybe not the best) on how to delivere IV, oral, nebulized and topical. Indeed there are other administration methodes not yet cear to us, such as sublingual and rectal. But I feel the four administration methodes we now know are enough and since our time is limitted we better focuss our energy on making the best out of what we allready know + search for other treatments with high potential. For example, Salinomycin IV. Salinomycin is as big as 3BP, I think, and because is so important I will soon come back to share with you some very exciting news regarding Salinomycin.

Back to 3BP:

Something that is puzzling to me is that in the patents, the 3BP suggested dose is 1.6 mg/kg for continuous intraarterial infusion (patent Jean-Francois Geschwind using NaOH as a buffer); 16.8mg/kg intravenously (patent Jean-Francois Geschwind using NaOH as a buffer); 200mg/kg!!! oral (patent Jean-Francois Geschwind using sodium bicarbonate as buffer) and 5mg/kg intravenously, oral, etc (patent from Peng Huang using sodium bicarbonate as buffer).

Dr. Ko on the other hand is suggesting a dose in the range of 1mg/kg as effective (various ways of administration) while concluding: The selected dosage level will depend upon a variety of factors including the activity of the particular compound of the present invention employed, or the ester, salt or amide thereof, the route of administration, the time of administration, the rate of excretion or metabolism of the particular compound being employed, the duration of the treatment, other drugs, compounds and/or materials used in combination with the particular compound employed, the age, sex, weight, condition, general health and prior medical history of the patient being treated, and like factors well known in the medical arts. Actual dosage levels of the active ingredients in the pharmaceutical compositions of this invention may be varied so as to obtain an amount of the active ingredient which is effective to achieve the desired therapeutic response for a particular patient, composition, and mode of administration, without being toxic to the patient.

Note that response has been seen so far for the following cases:

- ~2mg/kg 3BP IV (without buffer): melanoma case
- ~2mg/kg 3BP intraarterial (with Dr. Ko buffer): liver case
- ~2mg/kg 3BP oral (no buffer): reported on Cancer Compass by a cancer research scientist with prostate case
- ~2mg/kg 3BP IV (no buffer): at this dose I have seen response at my wife
- ~2mg/kg to 20mg/kg/day oral + topical: a friend whose lung tumor is gone and others visible much smaller in short time
- ~2mg/kg IV + oral +topical: another friend with visible tumors have been seriously reduces: breast case
- unknown dosage at Dayspring clinic: pancreatic case

Probably, Jcoancom will have a few more to add here.

However, note that as suggested by Dr. Ko in her patent the effectiveness of 3BP depends on so many aspects (such as condition of the patient, weight, administration time, buffers, other medication, etc.) that the dose has to be adjusted until it becomes effective while not being toxic. Administrating at the same time via different routes will increase the chance of success.

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Mon Jun 29, 2015 09:08 PM

Quote | Reply

On Jun 30, 2015 12:17 AM kcervantes wrote:

www.cancercuremedicine.com "" target="\_blank" rel="nofollow">http://www.cancercuremedicine.com " target="\_blank" rel="nofollow">www.cancercuremedicine.com

This website is very informative
Yes, is a nice one but somehow is not inviting me to go back often.. Probably because is not as interactive site?

Off course I understand Maria Athanassiou doesn’t want the ALTERNATIVE stamp on 3BP but that will happen since is difficult to see 3BP going mainstream as it is already effective in an unpatentable form and even if it is patented is so simple that it can be prepared in the kitchen.

Maria, you better join us here and help us make 3BP the CURE. Like Jcancom said, politico-social side is highly chalenging, and that is due to the reasons above. And as long as our world is driven by financial reasons, 3BP will have its best chance in the ALTERNATIVE world.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Mon Jun 29, 2015 09:10 PM
Quote | ReplyThank u Daniel! This is much needed for all of usQuote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterjetsparkle

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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Tue Jun 30, 2015 12:14 AM

Quote | Reply

On Jun 30, 2015 12:49 AM Danielus wrote:

On Jun 29, 2015 11:56 PM Jcancom wrote:

Um, I think on a matter of such importance one of our more esteemed (and at this time vacationing) members of the thread might offer some insight.
Sound like some of our dear members have great delegating skils :D

Is too important to stay away even during the holiday :)

I think with 3BP today we have a good idea (yet maybe not the best) on how to delivere IV, oral, nebulized and topical. Indeed there are other administration methodes not yet cear to us, such as sublingual and rectal. But I feel the four administration methodes we now know are enough and since our time is limitted we better focuss our energy on making the best out of what we allready know + search for other treatments with high potential. For example, Salinomycin IV. Salinomycin is as big as 3BP, I think, and because is so important I will soon come back to share with you some very exciting news regarding Salinomycin.

Back to 3BP:

Something that is puzzling to me is that in the patents, the 3BP suggested dose is 1.6 mg/kg for continuous intraarterial infusion (patent Jean-Francois Geschwind using NaOH as a buffer); 16.8mg/kg intravenously (patent Jean-Francois Geschwind using NaOH as a buffer); 200mg/kg!!! oral (patent Jean-Francois Geschwind using sodium bicarbonate as buffer) and 5mg/kg intravenously, oral, etc (patent from Peng Huang using sodium bicarbonate as buffer).

Dr. Ko on the other hand is suggesting a dose in the range of 1mg/kg as effective (various ways of administration) while concluding: The selected dosage level will depend upon a variety of factors including the activity of the particular compound of the present invention employed, or the ester, salt or amide thereof, the route of administration, the time of administration, the rate of excretion or metabolism of the particular compound being employed, the duration of the treatment, other drugs, compounds and/or materials used in combination with the particular compound employed, the age, sex, weight, condition, general health and prior medical history of the patient being treated, and like factors well known in the medical arts. Actual dosage levels of the active ingredients in the pharmaceutical compositions of this invention may be varied so as to obtain an amount of the active ingredient which is effective to achieve the desired therapeutic response for a particular patient, composition, and mode of administration, without being toxic to the patient.

Note that response has been seen so far for the following cases:

- ~2mg/kg 3BP IV (without buffer): melanoma case
- ~2mg/kg 3BP intraarterial (with Dr. Ko buffer): liver case
- ~2mg/kg 3BP oral (no buffer): reported on Cancer Compass by a cancer research scientist with prostate case
- ~2mg/kg 3BP IV (no buffer): at this dose I have seen response at my wife
- ~2mg/kg to 20mg/kg/day oral + topical: a friend whose lung tumor is gone and others visible much smaller in short time
- ~2mg/kg IV + oral +topical: another friend with visible tumors have been seriously reduces: breast case
- unknown dosage at Dayspring clinic: pancreatic case

Probably, Jcoancom will have a few more to add here.

However, note that as suggested by Dr. Ko in her patent the effectiveness of 3BP depends on so many aspects (such as condition of the patient, weight, administration time, buffers, other medication, etc.) that the dose has to be adjusted until it becomes effective while not being toxic. Administrating at the same time via different routes will increase the chance of success.

Your comments are always so much appreciated and respected.  And it is encouraging to read the positive case responses you have cited.

In regard to the last paragraph you wrote, it brought my mind back to a former post concerning Dr. Willams and his thoughts about the usage of 3-BP in his practice.  He seems to prefer using Keytruda, Optidivo, etc. -- and he  was concerned about the after-effects of 3-BP--stating the cancers could come back with a vengeance after its usage.

However, Dr. Ko wisely stated--as mentioned by you--that the effectiveness of 3-BP depends on many aspects.  And then one wonders if other physicians using 3-BP currently are adjusting the dosages appropriately for each individual patient--i.e. their condition, weight, meds, adminstration time, buffers.  All the while monitoring so that it continues to be favorable for the patient and non-toxic.  And also then one would have to consider the most effective adminstrative routes to use to gain success.  Again, determining that for each patient's case and needs.

Perhaps the complete scenario  suggested by Dr. Ko  has not been followed by those who  now discourage its usage and prefer other meds/immunotherapies --and that is why they are shying away from using this exceptional substance.  And thusly the failure to take all of these vital components mentioned by Dr. Ko into consideration for each individual could be creating the problem with which they are concerned--that of the cancers returning with a vengeance.  The human body is very complex--a holistic viewpoint is necessary to understand each patient's illness and ways to help his/her immune system.

In addition, the aspect of 3-BP being non-toxic is much more attractive than the side effects of some of the newly approved immunotherapy drugs to most patients.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Tue Jun 30, 2015 04:02 AM
Quote | ReplyAnyone know directions for 3BP enema?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Karantu on Tue Jun 30, 2015 11:20 AM
Quote | ReplyI think everyone here missing a point.

From cancercuremedicine.com  :

"3-bromopyruvate is a drug that is unstable in the human and easily detoxified"

I think conversations here should also concentrate on this detail. Once I read somewhere that even if you buy the correct chemical (3BP), from the best producer, it is not possible to use it at home. It is "rusting" (I am not sure if it is the correct word) in seconds(!) and getting black, as soon as it contacts to air (oxygen, ie. whenever you open its package). So, however you want to use 3BP, should be in the oxygen isolated lab environment, not our homes. And "rusted" 3BP is not 3BP anymore.

Is there anyone who can clearify this information?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Tue Jun 30, 2015 12:10 PM

Quote | Reply

On Jun 30, 2015 3:20 PM Karantu wrote:

I think everyone here missing a point.

From cancercuremedicine.com "" target="\_blank" rel="nofollow">http://cancercuremedicine.com " target="\_blank" rel="nofollow">cancercuremedicine.com  :

"3-bromopyruvate is a drug that is unstable in the human and easily detoxified"

I think conversations here should also concentrate on this detail. Once I read somewhere that even if you buy the correct chemical (3BP), from the best producer, it is not possible to use it at home. It is "rusting" (I am not sure if it is the correct word) in seconds(!) and getting black, as soon as it contacts to air (oxygen, ie. whenever you open its package). So, however you want to use 3BP, should be in the oxygen isolated lab environment, not our homes. And "rusted" 3BP is not 3BP anymore.

Is there anyone who can clearify this information?
From my lab guy:
Anything with a hydrate or H2O is not stable in humid or near moisture. It will grab moisture and clump up quite quickly. Try to open and close the container quickly and not leave the powder exposed to air for a long time as it will grab moisture from the air. Not exactly answering your Q. Yes, it is highly unstable, which is no doubt why delivery is part of the patent. But in its unstable presence, does it still help? Daniel and others have been using its unstable form and it appears to be providing benefit.Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterJcancom

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Tue Jun 30, 2015 01:02 PM
Quote | ReplyI obviously will defer to others more experienced on the thread for a complete explanation.

Yet, the evidence that has accumulated clearly shows that even though 3-BP is unstable, it is stable enough to be a powerful anti-cancer drug. The many animal studies have shown that without question in animals (at least) 3-BP can be an extremely powerful drug. Why would 3-BP be effective in animals if it were excessively unstable?

The early results in humans have also been impressive. The published studies have found that 3-BP is stable enough for its intended use.

At the same time, precautions need to be taken to make sure that 3-BP does not become too unstable. For example, precautions concerning temperature, light, pH, and moisture.

It should be noted that the instability of 3-BP is perhaps a benefit. 3-BP could be toxic in the body. It is known that 3-BP has a relatively short existence in the body. This limits its toxicity while giving it the opportunity to destroy substantial amounts of cancer.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Tue Jun 30, 2015 01:41 PM
Quote | Replyconfusing
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Tue Jun 30, 2015 05:37 PM
Quote | ReplyHi all, I wanted to share this idea with the people.
 TLS is a concern raised on this thread for 3-BP treatment. Many people when treating with 3-BP might have to wait days for lab results. This would be dangerous as markers such as potassium, uric acid etc. can change quickly and one would want this information to start treatment as soon as possible to reduce these risks. One of the most important risks with TLS is high potassium levels. Why not buy a portable potassium monitor?  Monitor below might be worth considering. High potassium is the most dangerous component of TLS as it can lead to sudden cardiac death. The potassium monitor measures saliva potassium (I am not entirely sure whether this will give a blood potassium measurement).

It costs about $300 which would be worth the reduced worry. You could take a potassium measurement whenever you liked and get an instant result. (With this knowledge you could immediately start treatment ( perhaps hydration     etc. .) This would be much better than waiting days for labs. Probably worth looking into.

A Portable potassium monitor.

http://www.horiba.com/us/en/application/material-property-ch

"Hyperkalemia [that is high potassium levels] remains the most dangerous component of the tumor lysis syndrome because it can cause sudden death due to cardiac dysrhythmia."

Would be great if there were other portable monitors available for example uric acid, calcium etc. .
Quote | Reply

### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Tue Jun 30, 2015 05:58 PM
Quote | ReplyThanks for this info J.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Tue Jun 30, 2015 06:10 PM
Quote | ReplyThere is actaully a uric acid monitor.

(This one is cheaper than the potassium monitor.)
Look's like you could have your own TLS home lab.

http://www.homegoutmeter.com/order.html

Also appears to be a calcium monitor. Now looking out for a phosphate detector. Serum creatinine? These monitors could greatly help manage the TLS problem. If you could take frequent measurements and receive immediate results, you would be in a much better position to manage any problems. Otherwise, you would be waiting days!!

Also, you could take several readings before 3-BP treatment and afterwards. You could watch the lysis power of 3-BP unfold in almost real time!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Tue Jun 30, 2015 06:23 PM
Quote | ReplyDoes anyone know whether you can take a blood sample from the IV site?

It would be less painful than all the pin pricks!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by darrenf on Wed Jul 01, 2015 06:50 AM
Quote | ReplyWOw this thread is getting very long.

I see [athttp://www.dayspringcancerclinic.com/3bp-cases/that athttp://www.dayspringcancerclinic.com/3bp-cases/that ] they admistered 3pb via IV then it looks like it was used as part of a oral program or am I reading this wrong.

so does anyone know the cost at dayspring clinic?

how are you using 3bp at home?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jul 01, 2015 09:34 AM
Quote | ReplyIt just got a little longer.

Dayspring charges somewhere between $25-30,000 for a month treatment of 3-BP and other therapies.

Such a round of treatment would need to be repeated or the cancer would return. The liver patient in Germany (2012) required about 10 rounds of treatment over a one year period to completely control his cancer.

Other treatment clinics are charging somewhat less than Dayspring. For example, the Atlanta clinic and the Toronto clinic.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jul 01, 2015 09:49 AM
Quote | ReplyI, two, am not totally sure exactly how Dayspring is dosing with 3-BP. The reference on their website seems somewhat ambiguous to me.

This is very true about the thread getting too long. Many people who truly need this treatment do not have time to read through an encyclopedia: They need a concise well organized document.

Perhaps we could post a document to the wiki that summarizes the ideas of this long thread into a simple easily readable recipe.

http://3bromopyruvate.wikia.com/wiki/Organization
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jul 01, 2015 11:17 AM
Quote | ReplyBy the way, welcome new poster! (One of the reasons this thread is growing is because there seems to have been a wave of interest. On January 1st, 2015 the thread count was less than 70, one month ago the count was 1000: We are almost ready to celebrate our 1500th post! Get ready for the party everyone!!!)

It is great to see that we are getting a nibble from down under!

Any comments about the potassium / uric acid / calcium etc. portable monitors for detecting TLS would be very much appreciated.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by lilyt on Wed Jul 01, 2015 11:24 AM
Quote | ReplyHello from Bulgaria,

Thank you for everything you guys shared and researched :) However, the thread is really long and I was interested if you managed to create a documents that highligts the major points. It would be greatly appreciated. I am interested in liver metastasis, do you have an idea what would be useful?The mets are from breast cancer, which got removed, however the metas in liver are about 9 and biggest is 7 cm. I am sorry I couldnt read the whole thread, I am up to page 80, but I got really confused, too much info..Thank you :) Also, sorry I am replying to Jcancom but still havent figured out how exactly to post...
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jul 01, 2015 11:39 AM
Quote | ReplyWelcome! Yeah, I am sort of the big mouth on the thread and if I just stayed quiet the thread would not have grown out of control. The boss is on vacation (I am worried some is going to ask me a skill testing question).

I think the wiki could really help organize things. These linear threads are brutal! I think we are overstretching our supply lines for this thread.

Liver cancer used TACE which seems to be very helpful for liver mets.

Replying is confusing on the thread. Pushing "reply" just means you extend the thead and not actually reply to a poster. It is confusing.

Summary statement are being written (by the boss). Stay tuned!

Germany seems to be a 3-BP treatment leader (especially Frankfurt am Main).
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Wed Jul 01, 2015 12:05 PM
Quote | ReplyWell, looks like my tumor markers have gone in the wrong direction  according to my recent blood test.

CA 27-29 has hit 121.4 and Ca 15-3 is now 72.2.  First one up 50 points from February--second one up 20.

Tumors in both breasts now--clavicular nodes enlarging and encroaching towards esophagus--and axillary lymph nodes also multiplying.  Now another one in the upper leg area.

Have been very ill with a damaged vagus nerve for the past 3 months and dealing with breathing, swallowing problems, tongue gets thick when talking, etc.  Ate chicken that was apparently contaminated with salmonella--plus spices on it must have also been contaminated.  Ended up with anaphylactic shock--ER visit--since then just not the same.  Never knew much about the vagus nerve and its vital importance for the heart, breathing, digestion--well, just a mess right now.

Very, very much need someone's suggestions about which method to use for 3-BP adminisitration.  Looks like i.v. method may not be available for me--no one to help with that.  Any ideas about the other methods--and which one (s) may be of the best help?  I usually have to go slowly with things--fragile right now.

Also concerned about handling tumor lysis syndrome appropriately.  There has been mention about tumor overload on some of the posts--how does one determine that?  Size of tumors?  Cancer tumor markers?

Have not been able to get a recent PET/CT scan--very difficult to get out with this vagus nerve problem.  However, all of my former scans always "lit up"---so I feel that 3-BP could really help me.

Would so much appreciate anyone's suggestions and help as to how to move forward with this.
Quote | Reply

by Moonlitnight on Wed Jul 01, 2015 12:20 PM

Quote | Reply
Jet, are you in the US? We have been able to get our naturopathic physician's help as we are obviously in a very dire situation. Unlike the medical oncologists, he gives a da\*n. Could you perhaps ask Daniel or Kim how to use/start an IV? We will have to learn this as daily professional administration would bankrupt us. I believe you can have a PICC put in place, but others know more about this than I.

I am wondering if you put a little ad in Craig's List asking for compassionate advice/introduction to the IV procedure, if a kindly health professional would help. Ask to see their credentials first of course.

On another thread it says that Dayspring have/had somewhere on their site that they also use oral route and enema.

I am wishing the best for you and sending reiki energy for a change in your energies right now.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jul 01, 2015 12:30 PM
Quote | ReplyI of course would defer on this.

In terms of routes of administration, remember that you could get home care to do almost everything for you to setup IV treatment. It would then just be a fairly simple task of getting the formulated 3-BP into the IV bag. Probably shouldn't give up on IV 3-BP.

Could also consider direct intratumoral injection. If the tumors are accessible then this could be ideal. The side-effects would then be minimized. Other treatments instead of 3-BP could also be used using this route.

I really think that using a variety of routes makes a great deal of sense. It is safer and more effective to directly target a tumor if possible. Keeping the respiratory and digestive system clear would be very wise in order to maintain general health when coping with cancer.

Looks like TLS is very manageable. The clinics are not reporting any problem when managed properly. The idea, if correct, of using portable monitors for detecting TLS symptoms would greatly reduce any lingering fears.

As well if you take the 3-BP treatment somewhat gradually, then TLS should probably never be a problem. The published patients were in such terrible general health that aggressive 3-BP treatment was considered necessary.

Waiting for the last minute would make things so much more difficult and possibly dangerous. Just buy the kit and micro-dose at start if you want to feel more comfortable with 3-BP. When you have metastatic cancer, waiting and not trying something that is probably quite safe seems like the worst strategy.

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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Wed Jul 01, 2015 01:21 PM

Quote | Reply

On Jul 01, 2015 4:20 PM Moonlitnight wrote:

Jet, are you in the US? We have been able to get our naturopathic physician's help as we are obviously in a very dire situation. Unlike the medical oncologists, he gives a da\*n. Could you perhaps ask Daniel or Kim how to use/start an IV? We will have to learn this as daily professional administration would bankrupt us. I believe you can have a PICC put in place, but others know more about this than I.

I am wondering if you put a little ad in Craig's List asking for compassionate advice/introduction to the IV procedure, if a kindly health professional would help. Ask to see their credentials first of course.

On another thread it says that Dayspring have/had somewhere on their site that they also use oral route and enema.

I am wishing the best for you and sending reiki energy for a change in your energies right now.
Heartfelt thanks to you and Jcancon for being so very kind.

Usually I am a very positive person--but learning about these markers going up, visibly seeing more tumors--well, last night it really hit me.  And I have been able to get Vit. C i.v.'s, etc.--but person just informed me that he  will not help with 3-BP at all.   Understandable since the person does not want any difficulties...could lose license, etc.

I do have a port (wary to access that one myself) -- have seen too many people with infected ports if sterile methods not done properly--major problems then can occur.  Otherwise can only use one arm for typical i.v.'s since the lumpectomy on the other side--but veins are shrinking and few now to use.

In answer to your question, I am located in the U.S. And you have been so kind--I know that you and your husband are in a dire situation.  Yet I know you continue to be brave--I am grateful that you have such a cooperative ND--but I know that each  day presents challenges to you also and it takes courage and persistence to face them. And I know first-hand about medical oncologists and their attitudes--horrible.  It is their way--or no way. Thanks--I don't want that type of  poison--either medically or emotionally!

And Jcancon, you have been just wonderful providing such excellent information and ideas to everyone.  Your input is of great value to so many.

Thank you both--you have brought tears to my eyes with your compassionate responses--very appreciative of your support and suggestions.

I needed that encouragement--again, I am grateful for your good-hearted suggestions and caring.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Wed Jul 01, 2015 01:43 PM
Quote | ReplyWe are all rooting for you Jetsparkle. The naturopath is showing us how to do it, not doing it himself. There is a fine line here I guess. I hope D will chime in and help.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Wed Jul 01, 2015 01:44 PM

Quote | Reply

On Jul 01, 2015 4:30 PM Jcancom wrote:

I of course would defer on this.

In terms of routes of administration, remember that you could get home care to do almost everything for you to setup IV treatment. It would then just be a fairly simple task of getting the formulated 3-BP into the IV bag. Probably shouldn't give up on IV 3-BP.

Could also consider direct intratumoral injection. If the tumors are accessible then this could be ideal. The side-effects would then be minimized. Other treatments instead of 3-BP could also be used using this route.

I really think that using a variety of routes makes a great deal of sense. It is safer and more effective to directly target a tumor if possible. Keeping the respiratory and digestive system clear would be very wise in order to maintain general health when coping with cancer.

Looks like TLS is very manageable. The clinics are not reporting any problem when managed properly. The idea, if correct, of using portable monitors for detecting TLS symptoms would greatly reduce any lingering fears.

As well if you take the 3-BP treatment somewhat gradually, then TLS should probably never be a problem. The published patients were in such terrible general health that aggressive 3-BP treatment was considered necessary.

Waiting for the last minute would make things so much more difficult and possibly dangerous. Just buy the kit and micro-dose at start if you want to feel more comfortable with 3-BP. When you have metastatic cancer, waiting and not trying something that is probably quite safe seems like the worst strategy.

Hi J. What do you mean by "buy the kit"?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jul 01, 2015 01:56 PM
Quote | ReplyBy the kit, I just meant the whole treatment kit. For example, 3-BP, IV bags, syringes, scientific balance, perhaps the potassium and other portable monitors-- everything you would need in order to treat.

Getting everything in place could take quite some time. Mostly people seem to wait and wait, though they still aren't ready to dose with 3-BP when they absolutely need to have it. It makes tremendous sense to buy the "kit" well in advance of when you will absolutely need it. As I mentioned, you could also start with micro-doses of say 1 mg IV just, or 1 mg neublized just to learn the procedure and feel comfortable with it.

This would be the safe way to treat.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Wed Jul 01, 2015 02:04 PM

Quote | Reply

On Jul 01, 2015 5:56 PM Jcancom wrote:

By the kit, I just meant the whole treatment kit. For example, 3-BP, IV bags, syringes, scientific balance, perhaps the potassium and other portable monitors-- everything you would need in order to treat.

Getting everything in place could take quite some time. Mostly people seem to wait and wait, though they still aren't ready to dose with 3-BP when they absolutely need to have it. It makes tremendous sense to buy the "kit" well in advance of when you will absolutely need it. As I mentioned, you could also start with micro-doses of say 1 mg IV just, or 1 mg neublized just to learn the procedure and feel comfortable with it.

This would be the safe way to treat.
Thanks J.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jul 01, 2015 02:08 PM
Quote | ReplyIt is so wrong that terminally ill cancer patients need to sneak around to get a treatment that might be very helpful to them. Especially when all available established treatments have already been tried without success.

Right To Try should apply for these patients.

We need some sort of legal judgment that establishes that the current legal interpretation of the law by governements is invalid. Democratic governments are not respecting the clear message that has been sent to them by the people. Governments are behaving ultra vires and it should be recognized that this behavior is illegal.

We need a judge somewhere who will do the right thing.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Wed Jul 01, 2015 02:14 PM
Quote | ReplyBig Pharma creates all the "rules" and the sheeple just follow them.

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jul 01, 2015 02:26 PM
Quote | ReplyAnd govenment enforces the rules.

I am starting to see the point of the American freedom perspective. My friends Mr. Smith, Mr. Weston, Mr. Howtizer, Mr. Kalashnikov and others simply reframe the whole discussion. Anyone have any further questions? They pretty much finish the conversation. In America this is completely understood in the social and political system.

From the Canadian point of view, the idea that people need to assert their rights over the power of government with weapon systems seems ridiculouts, though 3-BP shows that it might be necessary.

It is noteworthy that Arizona has some of the most relaxed gun control rules in America. Open carry is legal in Arizona. In a place like that it is hard for bereaucrats to prevent  terminally ill cancer patients from getting treatments that might help them.

Quote | Reply

### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Wed Jul 01, 2015 04:04 PM

Quote | Reply

On Jul 01, 2015 6:26 PM Jcancom wrote:

And govenment enforces the rules.

I am starting to see the point of the American freedom perspective. My friends Mr. Smith, Mr. Weston, Mr. Howtizer, Mr. Kalashnikov and others simply reframe the whole discussion. Anyone have any further questions? They pretty much finish the conversation. In America this is completely understood in the social and political system.

From the Canadian point of view, the idea that people need to assert their rights over the power of government with weapon systems seems ridiculouts, though 3-BP shows that it might be necessary.

It is noteworthy that Arizona has some of the most relaxed gun control rules in America. Open carry is legal in Arizona. In a place like that it is hard for bereaucrats to prevent  terminally ill cancer patients from getting treatments that might help them.
The thing that stuns me is that people are largely clueless of how the world operates, believing that they need to be protected and that those who have a string of university degrees (programs developed by the powers-that-be) somehow have the knowledge/wisdom to control them this way. Fear is generated by the media (also "owned") and so we are away to the races. Nowhere is this more obvious, at least where I live, than in the medical system. Dare write the word "cancer" on a natural product shown in university studies to augment the immune response and suppress cancer, and you will be subject to a raid and possible shut-down. Medicinal mushrooms are a classic example of this. Outstanding studies from Mayo and MSK and elsewhere in the world, but the supplement manufacturers are not permitted to make mention of them. The governments own the word "cancer." Make no mistake about it. Also, we have to be protected against our ignorant selves by having governments cut off access to helpful CAM in case we decide to forgo chemotherapy. Like this is not OUR choice to make. Like we are too stupid to make it in an informed way.

Sorry for the rant, which is probably not appropriate use of this thread.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jul 01, 2015 04:37 PM
Quote | ReplyNo I think a rant is good ever once and a while.

We would not be in this absurd circumstance if 3-BP had went through the system in the regular way. I do not think I would be so active, if the proper authorities were taking care of this. The problem is they have not taken care of this.

If they wanted to do a really good coverup of this they could have. It has just been a real fumble. Many on this thread can appreciate this viewpoint. It should not take 15 (or more) years after the initial scientific discovery to move it into the clinic. At this point patients should not have to sneak around to get this treatment.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Wed Jul 01, 2015 05:42 PM

Quote | Reply

On Jul 01, 2015 8:04 PM Moonlitnight wrote:

On Jul 01, 2015 6:26 PM Jcancom wrote:

And govenment enforces the rules.

I am starting to see the point of the American freedom perspective. My friends Mr. Smith, Mr. Weston, Mr. Howtizer, Mr. Kalashnikov and others simply reframe the whole discussion. Anyone have any further questions? They pretty much finish the conversation. In America this is completely understood in the social and political system.

From the Canadian point of view, the idea that people need to assert their rights over the power of government with weapon systems seems ridiculouts, though 3-BP shows that it might be necessary.

It is noteworthy that Arizona has some of the most relaxed gun control rules in America. Open carry is legal in Arizona. In a place like that it is hard for bereaucrats to prevent  terminally ill cancer patients from getting treatments that might help them.
The thing that stuns me is that people are largely clueless of how the world operates, believing that they need to be protected and that those who have a string of university degrees (programs developed by the powers-that-be) somehow have the knowledge/wisdom to control them this way. Fear is generated by the media (also "owned") and so we are away to the races. Nowhere is this more obvious, at least where I live, than in the medical system. Dare write the word "cancer" on a natural product shown in university studies to augment the immune response and suppress cancer, and you will be subject to a raid and possible shut-down. Medicinal mushrooms are a classic example of this. Outstanding studies from Mayo and MSK and elsewhere in the world, but the supplement manufacturers are not permitted to make mention of them. The governments own the word "cancer." Make no mistake about it. Also, we have to be protected against our ignorant selves by having governments cut off access to helpful CAM in case we decide to forgo chemotherapy. Like this is not OUR choice to make. Like we are too stupid to make it in an informed way.

Sorry for the rant, which is probably not appropriate use of this thread.
As cancer patients--or their caregivers--we have heard, seen, and experienced a great deal of injustice and farcical attitudes by those "in control".

Rant all you want to--we appreciate truth--it is breath of fresh air compared to what has been dished out to most of us!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Thu Jul 02, 2015 12:55 PM
Quote | ReplySomeone recently suggested to me that 3-BP could be added to a lipodermal cream--i.e. PCCA lipo cream.

I believe it was mentioned formerly that DMSO, 3-BP,  etc. could be used as a topical formula with very good results.

Just googled this:  3-bromopyruvate used with lipodermal cream.  What came up was this:

Patent EP 2063884B1--apparently more than 50 pages to read about study done using Vitamin E and 3-BP with lipo cream and results show  apoptosis of cancer cells.

Can also be located at www.google.com /patents/EP2063884B1?cl=en

Way too scientific article for my understanding--but someone with a better capability/knowledge of all of this may find it useful and informative.

Apparently the combo of the Vitamin E and 3-BP was the most efficacious rather than using  the 3-BP alone...interesting.

Any comments?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Thu Jul 02, 2015 01:00 PM
Quote | ReplyAnd I just noticed that the "private reply" capability has been removed under my name in the left-hand column--no longer there for me to use.  What happened there?

Others still seem to have it under their names....what's up?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jul 02, 2015 01:04 PM
Quote | ReplyI think it's ok. Mine is the same.

You can't private reply to yourself!!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Thu Jul 02, 2015 01:12 PM

Quote | Reply

On Jul 02, 2015 5:04 PM Jcancom wrote:

I think it's ok. Mine is the same.

You can't private reply to yourself!!
Very strange, Jcancon--now the ability is back.  The words "private reply" had been completely erased under my name--now they are back again.

Perhaps just a glitch in the system?  Oh, well...
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Thu Jul 02, 2015 01:14 PM

Quote | Reply

On Jul 02, 2015 4:55 PM jetsparkle wrote:

Someone recently suggested to me that 3-BP could be added to a lipodermal cream--i.e. PCCA lipo cream.

I believe it was mentioned formerly that DMSO, 3-BP,  etc. could be used as a topical formula with very good results.

Just googled this:  3-bromopyruvate used with lipodermal cream.  What came up was this:

Patent EP 2063884B1--apparently more than 50 pages to read about study done using Vitamin E and 3-BP with lipo cream and results show  apoptosis of cancer cells.

Can also be located at www.google.com "" target="\_blank" rel="nofollow">http://www.google.com " target="\_blank" rel="nofollow">www.google.com  /patents/EP2063884B1?cl=en

Way too scientific article for my understanding--but someone with a better capability/knowledge of all of this may find it useful and informative.

Apparently the combo of the Vitamin E and 3-BP was the most efficacious rather than using  the 3-BP alone...interesting.

Any comments?
Very interesting Jetsparkle. So I have DMSO gel here. If I add a vit E (d-alpha tocopherol) capsule, I wonder how much 3BP powder. Do you have any info on that? Perhaps D could comment from his perch on the beach. Our 3BP appears to be arriving today or tomorrow. I wonder too, if I apply it close to the prostate, if this would have any additional benefit (just wondering that as no one could possibly answer specifically). Wishing you well.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Thu Jul 02, 2015 01:15 PM
Quote | ReplyIt is gone again--very odd.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Thu Jul 02, 2015 01:17 PM

Quote | Reply

On Jul 02, 2015 5:14 PM Moonlitnight wrote:

On Jul 02, 2015 4:55 PM jetsparkle wrote:

Someone recently suggested to me that 3-BP could be added to a lipodermal cream--i.e. PCCA lipo cream.

I believe it was mentioned formerly that DMSO, 3-BP,  etc. could be used as a topical formula with very good results.

Just googled this:  3-bromopyruvate used with lipodermal cream.  What came up was this:

Patent EP 2063884B1--apparently more than 50 pages to read about study done using Vitamin E and 3-BP with lipo cream and results show  apoptosis of cancer cells.

Can also be located at www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  "" target="\_blank" rel="nofollow">http://www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  " " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  "" target="\_blank" rel="nofollow">http://www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  " " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  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target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  "" target="\_blank" rel="nofollow">http://www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  /patents/EP2063884B1?cl=en

Way too scientific article for my understanding--but someone with a better capability/knowledge of all of this may find it useful and informative.

Apparently the combo of the Vitamin E and 3-BP was the most efficacious rather than using  the 3-BP alone...interesting.

Any comments?
Very interesting Jetsparkle. So I have DMSO gel here. If I add a vit E (d-alpha tocopherol) capsule, I wonder how much 3BP powder. Do you have any info on that? Perhaps D could comment from his perch on the beach. Our 3BP appears to be arriving today or tomorrow. I wonder too, if I apply it close to the prostate, if this would have any additional benefit (just wondering that as no one could possibly answer specifically). Wishing you well.
I just noticed that the patent uses a pro-oxidant analogue of vitamin E, not the antioxidant tocopherol.

### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Thu Jul 02, 2015 01:24 PM

Quote | Reply

On Jul 02, 2015 5:14 PM Moonlitnight wrote:

On Jul 02, 2015 4:55 PM jetsparkle wrote:

Someone recently suggested to me that 3-BP could be added to a lipodermal cream--i.e. PCCA lipo cream.

I believe it was mentioned formerly that DMSO, 3-BP,  etc. could be used as a topical formula with very good results.

Just googled this:  3-bromopyruvate used with lipodermal cream.  What came up was this:

Patent EP 2063884B1--apparently more than 50 pages to read about study done using Vitamin E and 3-BP with lipo cream and results show  apoptosis of cancer cells.

Can also be located at www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  "" target="\_blank" rel="nofollow">http://www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  " " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  "" target="\_blank" rel="nofollow">http://www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  " " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  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rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  " " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  "" target="\_blank" rel="nofollow">http://www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  " " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  "" target="\_blank" rel="nofollow">http://www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  " " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  "" target="\_blank" rel="nofollow">http://www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  " target="\_blank" rel="nofollow">www.google.com " target="\_blank" rel="nofollow">www.google.com  /patents/EP2063884B1?cl=en

Way too scientific article for my understanding--but someone with a better capability/knowledge of all of this may find it useful and informative.

Apparently the combo of the Vitamin E and 3-BP was the most efficacious rather than using  the 3-BP alone...interesting.

Any comments?
Very interesting Jetsparkle. So I have DMSO gel here. If I add a vit E (d-alpha tocopherol) capsule, I wonder how much 3BP powder. Do you have any info on that? Perhaps D could comment from his perch on the beach. Our 3BP appears to be arriving today or tomorrow. I wonder too, if I apply it close to the prostate, if this would have any additional benefit (just wondering that as no one could possibly answer specifically). Wishing you well.
I would wait until you hear from D about this. Very crucial to get amounts and application correct of anything used.  Don't attempt it without more knowledge!

I scanned the patent article very briefly--eyes were about to cross trying to decipher everything--not sure at all about amounts they were using and what would be appropriate.  Such a technical article.   Please err on the cautious side until we know more about this combo!

Take good care and wishing you well, too!

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jul 02, 2015 01:37 PM
Quote | ReplyAt the end of the patent they actually provide a human report with the cream. They monitored the serum level of the a-TOS and targeted treatment to reach 50M.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Thu Jul 02, 2015 01:42 PM

Quote | Reply

On Jul 02, 2015 5:37 PM Jcancom wrote:

At the end of the patent they actually provide a human report with the cream. They monitored the serum level of the a-TOS and targeted treatment to reach 50M.
Were you able to find what amounts they were using in the cream?  Migraine today-hard to read much--and article is way above my brain anyway...!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jul 02, 2015 01:46 PM
Quote | Reply"The blood plasma levels were monitored and levels of a-TOS in the plasma attained 50 M over prolonged periods during continual application.
This is more than sufficient to kill the cancer cells based on in vitro analysis.

...After 4 weeks of applying the lipodermal preparation, the patient showed recovery with much improved anterior chest wall mass by CT scan with a decrease clinically by 50%
and with ongoing a-TOS therapy, the patient continued to improve clinically.

a-TOS formulation: 500gms of Lipoderm cream plus 60gms a-TOS compounded by the hospital pharmacy. About 30gms of compounded mix was administered every few days, and the upper body was wrapped in plastic film ("saran wrap") to improve absorption."

Not clear where you can obtain the a-TOS.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jul 02, 2015 01:49 PM
Quote | ReplyAlso:

"Example 11 - a-TOS inhibits tumor growth irrespective of erbB2 status.
For in vivo studies, the present inventors first determined whether a-TOS
could suppress tumor growth in an animal model of breast cancer with low erbB2 expression, given that up to a third of human breast cancers express high levels of this receptor tyrosine kinase"

" a-TOS was found to be statistically more effective (p<0.05 by analysis of covariance) than 3-BP at inducing regression of the growth of breast tumors in these animals, resulting in a reduction in the average size of tumors by about 30-40% over the 2 weeks of treatment."

..."However, the instant studies revealed resistance of erbB2 high-expressing cells to 3-BP. Since this receptor is commonly expressed at elevated levels in human breast cancer"
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Thu Jul 02, 2015 01:56 PM

Quote | Reply

On Jul 02, 2015 5:49 PM Jcancom wrote:

Also:

"Example 11 - a-TOS inhibits tumor growth irrespective of erbB2 status.
For in vivo studies, the present inventors first determined whether a-TOS
could suppress tumor growth in an animal model of breast cancer with low erbB2 expression, given that up to a third of human breast cancers express high levels of this receptor tyrosine kinase"

" a-TOS was found to be statistically more effective (p<0.05 by analysis of covariance) than 3-BP at inducing regression of the growth of breast tumors in these animals, resulting in a reduction in the average size of tumors by about 30-40% over the 2 weeks of treatment."

..."However, the instant studies revealed resistance of erbB2 high-expressing cells to 3-BP. Since this receptor is commonly expressed at elevated levels in human breast cancer"
Jcancon,

Thanks for all of this further break-down and information--will have to re-read several times before it will all sink in.  But very interesting overall--may prove to be helpful in the long run.

So much to learn...more details to discern.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jul 02, 2015 01:59 PM
Quote | ReplyAre there actual procedures that would allow you direct access to the prostate?

For example, injections from the rectum? If you could directly target the prostate, then 3-BP could be especially effective. Perhaps also could apply a paste near the prostate through the rectum.

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Thu Jul 02, 2015 02:02 PM
Quote | ReplyOK so alpha TOS is alpha tocopherol succinate, which I have here in capsule form. What if this is blended into DMSO gel and the 3BP added...
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Thu Jul 02, 2015 02:04 PM

Quote | Reply

On Jul 02, 2015 6:02 PM Moonlitnight wrote:

OK so alpha TOS is alpha tocopherol succinate, which I have here in capsule form. What if this is blended into DMSO gel and the 3BP added...
alpha-TOS is known for its anticancer action when taken orally as well.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Thu Jul 02, 2015 02:08 PM

Quote | Reply

On Jul 02, 2015 6:02 PM Moonlitnight wrote:

OK so alpha TOS is alpha tocopherol succinate, which I have here in capsule form. What if this is blended into DMSO gel and the 3BP added...
Problem is we do not have the correct proportions of each--have to make sure of that--don't want to complicate anything with the patient.

Wait to see if more can be gleaned from this--I know time is of the essence for many of us.  But essential we do not do the opposite of our intentions and cause any harm instead.

We need to learn more about this...
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Thu Jul 02, 2015 02:58 PM
Quote | ReplyWe do that.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jul 02, 2015 06:28 PM
Quote | ReplyDoes anyone know how to do patent searches?

I searched for the word 3-Bromopyruvate on one of the patent sites and the noted patent above was not included. There were only a few of the early results for 3-BP. Interested to have a comprehensive list of 3-BP patents.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jul 02, 2015 11:29 PM
Quote | ReplyAnother positive phase 1 clinical trial with nanocells. Wonder when Right to Try will apply.

http://finance.yahoo.com/news/engeneic-asbestos-diseases-res
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Fri Jul 03, 2015 07:19 PM
Quote | ReplyHas anyone heard from Howard P lately?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by lilyt on Sat Jul 04, 2015 07:54 AM
Quote | ReplyHi guys, please let me know if you know any clinic in Europe offering 3 bromo pyruvate treatment...
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jul 04, 2015 10:47 AM
Quote | ReplyThere appear to be a few clinics treating with 3-BP in Germany. None of them advertise.Treatm ent is not cheap, though some of these clinics seem to use a pay as you go approach which makes the financial side more managable.

It is a little slow on the thread now, as some of the posters are taking a well deserved holiday. You could expect some pms over the next week or two with specific clinics.

Best Wishes
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jul 04, 2015 10:57 AM
Quote | ReplyIt surprises me how many potentially useful cancer treatments sit on the shelf almost indefinitely. It is not only 3-BP.

The sugar side of cancer apparently has been recognized since Christmas Eve, 1887. The article from the below url was written at the start of 2014, though the recent replies on the site note that clinical trials have still not resolved the question. Patients are often placed in the difficult situation of accepting medical advice from their doctor who might even mention that the treatment will likely be ineffective and cause serious side effects or read anecdotal reports similar to the ones in the post that might never be substantiated in scientifically valid clinical trials.

The patient would be confronted with two options: both bad. why doesn't science do better than this?

http://eatingacademy.com/nutrition/way-exploit-metabolic-qui
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jul 04, 2015 11:19 AM
Quote | ReplyWe start our treatment next week so will post about that.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jul 04, 2015 11:49 AM
Quote | ReplyThat is great news!

What is your treatment plan? Include paracetamol? Dosage? Any portable monitors? Butyrate? Frequent labs? IV and or nebulized? Liquid glutathione? LDH?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jul 04, 2015 12:21 PM

Quote | Reply

On Jul 04, 2015 3:49 PM Jcancom wrote:

That is great news!

What is your treatment plan? Include paracetamol? Dosage? Any portable monitors? Butyrate? Frequent labs? IV and or nebulized? Liquid glutathione? LDH?
Acetaminophen (ugh!) as in T3s as he cannot take ibuprofen while on 3BP, 900 - 1200 mg day. Start with .5 mg/kg IV, I think 3x weekly. Ordering the potassium and urea monitors and calcium/butyrate. Don't we need a glutathione depleter not enhancer? I will have to check that one. Maybe I'm confused. LDH was up to almost 3000 last time I checked but we haven't had a number on that for a while. Next Tues, I will ask the palliative doc for a full profile.
Quote | Reply

### RE: Anyone used 3bp (3-bromopyruvate)?

by kcervantes on Sat Jul 04, 2015 12:27 PM
Quote | ReplyMoonlitnight -

I believe its Sodium Butyrate.  This is what D suggested.  Also, I would pair it with Artemisinin.  Ive heard the 2 work well together
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jul 04, 2015 12:32 PM

Quote | Reply

On Jul 04, 2015 4:27 PM kcervantes wrote:

Moonlitnight -

I believe its Sodium Butyrate.  This is what D suggested.  Also, I would pair it with Artemisinin.  Ive heard the 2 work well together
OK Kim thank you for that. I haven't ordered yet. Doing that today through Amazon prime and driving down across the border to pick it up along with the meters. I think I may have to put it off for a few days until we have the right stuff. We are having IV artesunate (artemisinen) but not in the same IV obviously.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Sat Jul 04, 2015 01:11 PM

Quote | Reply

On Jul 04, 2015 3:19 PM Moonlitnight wrote:

We start our treatment next week so will post about that.
Just want you to know that only the best  of wishes, positive thoughts, and much compassion are in our hearts for success and recovery.  Please keep us all posted!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jul 04, 2015 01:27 PM
Quote | ReplyThat seems like a fairly good plan.

Paracetamol (acetaminophen) can really amp up the response.

Perhaps could start with only 3-BP and see if there is a response. Could do labs the day before, of and after treatment to capture any move on the markers. As soon as it can be established that there is a treatment response relationship you can move ahead and use strategies to magnify the response. The melanoma doctors started with a modest dose of 1.0 mg /kg to establish that 3-BP was active for the patient. The substantial decline in his LDH after 3-Bp treatment clearly indicated that 3-BP was active for him. This is the safe way of determining activity of 3-BP.

With 3-BP, the treatment-response relation was quickly obvious with both published patients. You could then treat according to the response variables (LDH, potassium etc.). This is what the melanoma patients' doctors did.

If this relationship were not to emerge, then you could move onto other treatment options.

Admittedly from time to time my posts are somewhat speculative in nature. For example, about the monitors (potassium, uric acid ...). I was just putting that out there. I would want to double check that the monitors are measuring the right kind of potassium, uric acid ... (that is serum versus saliva etc. ).

If these monitors monitor what they appear to be monitoring this would rank right up there in my all time hall of fame for great ideas. Having an instant readout for markers for possible TLS... well, it is obviously worth the price (whatever the price). Alternatively, you could sit around for several days biting your fingernails for a lab to report back.

Wonder if I could patent it!

The glutathione enhancer was suggested by a more senior poster to dampen 3-BP if 3-BP worked too well. For example, during nebulizer treatment you might become worried that the treatment was too effective, glutathione would counteract the paracetamol (or just boost glutathione levels if paracetamol were not used).

Obviously, you will want to have more frequent labs. The melanoma patient was receiving daily labs during 3-BP treatment.

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### RE: Anyone used 3bp (3-bromopyruvate)?

by lilyt on Sat Jul 04, 2015 01:29 PM
Quote | ReplyThank you for your answers. I guess if the price is high we are not going with this option for treatment in facility. Probably its much wiser for me to get the components together from now in case other things like Xeloda dont really work. My grandma has liver metastases and I cant just let her go like that without trying,even in the name of science its worth giving a try... I am trying to not looking for ready answers, but would you please advise me on getting 3 bromo pyruvate from European facility? I saw Sigma Aldrich are selling it, but they have order for fom where you explain if you are facility/university and so on. How to get around that, any idea? I am afraid they wont agree to resell if I mention the truth about using it..
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jul 04, 2015 02:02 PM
Quote | ReplyThe unofficial price quotes from the German clinics do not seem that unreasonable. Plunking down US $30,000 and not even know if 3-BP will be effective for a partiicular patient seems like too much of a financial gamble. The Toronto clinic of US $300 an injection seems very reasonable. You would know if the treatment were working before spending a large amount of money. At the Toronto clinic price, letting the experts do the treating makes the most sense to me (though this is for Canadian residents only). The German clinics also have more of a per day / per week payment plan which also makes things more affordable.

I definitely think that getting the kit together before it is absolutely absolutely required is the way to go. Things always can crop up with cancer ( bleeds, organ failure, new mets ...). You want to have the whole set up and know what you need to do well in advance. Some of the components are tricky to get. Even IV bags are restricted items! Also you could always try micro dosing just to get a feel for it.

3-BP might not work out for you. Some cancers probably will display resistance. You want to know well in advance what your next line of treatment will be if 3-BP is not likely to be effective.

A few of the thread members are now treating or close to treating with 3-BP. You will be able to access their insights.

Sigma seems very well aware of the off label uses of 3-BP and do not appear willing to supply it as a treatment. A thread member was turned down once Sigma realized that the shipping address was not a university/pharmaceutical company. Other American suppliers are more flexible. It is best to stay with American or European suppliers. The Chinese are very willing to sell 3-BP, though concerns have been raised on this thread about their product.

People on the thread can help you over the hurldes. Yet, it is somewhat unclear to me whether there is a particular problem in shipping 3-BP from America to Europe. The problem might be that 3-BP could be considered a hazardous chemical and that might raise questions during shipping.

Yes, it is really unfortunate that more people have not realized that by trying a different treatment choice that everyone could gain by this knowledge. Having millions of cancer all receiving the same ineffective treatment must certainly qualify for Einstein's definition of insanity ( Doing exactly the same thing and expecting a different outcome). Thank you for thinking of trying something different. Innovation is the only way humanity has ever made progress.

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### RE: Anyone used 3bp (3-bromopyruvate)?

by MikeMcD on Sat Jul 04, 2015 02:05 PM
Quote | ReplyNEW WARBURG BLOCKER IS "SR9243"   LOOKS TOO GOOD TO BE TRUE...
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Jul 04, 2015 02:29 PM
Quote | ReplyA pharmaceutical company has finally found a way to patent the Warburg effect?

I guess that is good news. It would be the end of DYI cancer treatment which I would be all in favor of ending.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by lilyt on Sat Jul 04, 2015 02:40 PM
Quote | ReplyTo be honest, thats how I got to 3 bromo pyruvate, by finding out about SR9243,someone has commented on that mentioning 3 bromo pyruvate.

http://www.genengnews.com/gen-news-highlights/depersonalized

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Moonlitnight on Sat Jul 04, 2015 02:51 PM
Quote | ReplyMe too...my brain is unravelling as I try to pull all this together for my guy.
Quote | Reply