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Síndrome de deficiencia de glucosa tipo 1: ¿Qué tan bajo es demasiado bajo?

**Síndrome de**
deficiencia de glucosa tipo 1:

¿Qué tan bajo es demasiado bajo?

El síndrome de deficiencia del transportador de glucosa tipo 1(SGLUT-1. OMIM 606777) es un desorden metabólico, el cual nos
recuerda cuan vinculadas están las funciones cerebrales y el metabolismo cerebral. El acoplamiento de estos dos últimos es el sustituto biológico por
hecho de que los nutrientes se lleven al cerebro por medio de la circulación.

En pocas palabras el Glut-1 es un trastorno genético que altera el metabolismo cerebral haciendo que la glucosa no se transporte adecuadamente al cerebro, dejándola
muerta de hambre por la energía que necesita para crecer y funcionar.

Un claro ejemplo
de la deficiencia de nutrientes es la hipoglucemia, ya que esta disminuye la posibilidad de que los combustibles y nutrientes esenciales lleguen al metabolismo cerebral.
Algunos de los síntomas que se reflejan con relación a la hipoglucemia son la irritabilidad del sistema nervioso el cual es una advertencia, debido a que si la glucosa en la sangre sigue bajando aún más y no se restaura a la normalidad dentro de un periodo de tiempo, puede
dar paso a un daño irreversible como lo es el coma.

La deficiencia de Glut1 es causada por una mutación en el gen SLC2A1, que regula la proteína transportadora de Glut1. Existen diferentes tipos de mutaciones de este gen. En el artículo se menciona que se han estado trabajando con modelos en ratones para recabar más información y resolver el debate en torno a la necesidad de nutrientes neuronales. Se hace hincapié en que la glucosa es el principal y obligado combustible para la energía del cerebro.

La deficiencia de Glut1 causa una serie de síntomas que pueden variar considerablemente en los pacientes, los más comunes pueden incluir convulsiones, trastornos del movimiento, trastornos del habla y del lenguaje y retrasos en el desarrollo.  En el artículo se presenta la tabla1 con especulaciones relativas a la correlación fenotipo-genotipo y su función de transporte de glucosa a través de la BBB.

Tabla 1: Especulaciones relativas a la correlación fenotipo-genotipo y la funcionalidad del transporte de glucosa a través de la BBB. El transporte normal se asocia con un 100% de actividad de Glut1 y la relación CSF / glucosa en sangre es de 0,65 en el post-absorción.

En conclusión, el papel que juega la Glut1 en la disfunción
cerebral mínima y sintomatología neurológica intermitente todavía necesita investigarse con más detalle. Pero es necesario recalcar la importancia de los
diagnósticos. Glut1 puede ser difícil de diagnosticar clínicamente, particularmente si los síntomas son sutiles o intermitentes. Sin embargo, un valor bajo de glucosa en LCR  y un valor normal o baja lactato CFS realza dramáticamente el índice de sospechas con respecto a un diagnóstico. Todo el paciente con una condición neurológica sin explicación debe someterse a este procedimiento de diagnóstico.

Referencia: 52

De Vivo DC, Wang D. Glut1 deficiency: CSF glucose. How low is too low? Rev Neurol (Paris)
2008;164:877–80.
Beethoven (LA) and Hiro Hamada

Hiro Hamada went inside the San Fran sokoyo dog kennel walked up to the receptionist and ask for a list of the dogs in the kennel he look at the list and picked beethoven.

”room 2156 hears the key have fun.” The receptionist said with a smile.

The boy took the key and put in his pocket and search for the room until he found it.

”this looks like the place.” he took the key and unlocked the door and it opened to revel a giant Saint Bernard sleeping.

Hiro walked up to the dog and started petting him on the head.

”time to wake up boy.”

The dog woke up and saw the boy and immediately jumped on him placing his paws on his shoulders and licking Hiro face and cheeks.

”HAHAHAHAHAHAHAH good boy!!!”

after several minutes of Beethoven licking he got off Hiro and sat on his back legs panting.

”well at least I know you are friendly.”

hiro started scratching the dog behind the ears until he found his collar.

”Beethoven huh well nice to meet you my name is hiro.”

With that Beethoven tackled hiro to the floor and started licking his face and cheeks and often his chin sending slobber everywhere.

”HAHAHAHAHAHAHAH!!!”

After a while the dog increased the speed of his licking of hiro face and cheeks and chin sending slobber everywhere and the boys laughter being muffled by the dogs licking.

HAHAHAHAHAHAHAHAHAH good boy very good boy!!!”

after several more minutes of licking the dog began to finish off hiro by once again increasing the speed of his licking of hiro cheeks face and chin sending huge amounts of slobber everywhere.

“HAHAHAHAHAHAHA”

after several hours of nonstop licking hiro passed out with Beethoven still on him licking his face.

when beethoven realized that hiro was passed out he got off of him and went back to his bed and went to sleep.
Clifford and Lincoln Loud

Lincoln whistled a tune as he walked down the sidewalk in the direction of Emily's house. He saw poster for a tree asking for a dog-walker and saw the huge amount of money. The picture displayed a red dog laying in his dog house. According to the poster, the dog's name was Clifford. He didn't know why some kids around the block gave him weird looks as he headed to Emily's home and started calling him the walker for Clifford.

Lincoln didn't see what the big deal was, Clifford looked like a nice dog. Sure he looked big, but from his experience big dogs were more tolerant than small dogs. Charles was tolerant but he was the only small dog Lincoln knew who didn't have attitude problems.

He remembered being interviewed by Emily's parents, at first they seemed worried that someone as young as him would walk Clifford but then they were impressed with his bio and gave him the job. He was known by friends, family, and enemies as 'The Man With the Plan'.

When he arrived at the house Emily let him in and told him to give her a call if Clifford was too much. Then she told him that Clifford was in the backyard and left.

Lincoln headed out the backyard, he was told Clifford was very playful and very lovable so he'll see how Clifford reacts after he gave his hand a good sniff then-

Lincoln froze when he saw the dog house. The dog house was over 25-freaking-feet-tall! He hastily took out the poster to look at the picture, this was dog house from the poster. If this was the size of the dog house then that meant Clifford must be-

He heard booming footsteps and froze as a giant red paw was placed directly behind him. He slowly turned around and had to tilt his head to see Clifford in all in gigantic-size glory. Clifford barked released a loud bark and lowered his head right in front of Lincoln, shaking the ground in the process. Lincoln stumbled a bit when Clifford pushed his gigantic snout into Lincoln's body. The big red dog began sniffing him. Normally Lincoln wouldn't mind but since this dog was the size of Godzilla, the white haired boy just hoped Clifford wouldn't get the idea to treat him like a chew toy.

Clifford soon stopped sniffing him and wagged his tail wwith his tongue hanging in the front. That was the only warning Lincoln got.

SLURP!

The giant dog licked Lincoln with his long tongue that dragged from his foot, to his shirt, and all the way to his face.

"MMPPPHHH!" Lincoln was dragged up into the air by the slurp before the tongue swiped off and Lincoln fell back to the ground on his bottom.

Clifford barked excitedly at his new playmate who was covered in saliva and had a stunned look on his face and his hair had bent swept back.

"Gross." Lincoln muttered, with a hint of laughter in his voice. He then proceeded to wipe the saliva off his face and fix his hair.
Beethoven (LA) and David (ADGtH2)

video File:PlaceholderBeethoven finds david in the woods and chases him and when he catches him.

Beethoven pounces him and plants his paws so that he can't move and starts licking him on his frontside.

Beethoven then moves on to licking his neck by wrapping his huge tongue around his neck which david quite enjoyed Beethoven noticed this and switched from his neck to stomach thoroughly

then beethoven moves from his stomach back to his neck

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Spike and Peter Pan

Peter Pan woke up on the deck of a ship tied up he wondered if he was on captain hook’s ship until he heard a voice.

”Well looks like you woke up.”

He saw a pirate walking up to him with a smug look on his face.

”Alright pal why the flip did you tie me up?” Peter asked the pirate.

”First off name’s Sinbad and second you’re tied up because I just wanted to mess with ya honestly.”

”So you tied me up just to mess with me why you!” Peter struggled to escape.

”well I am not the only person who wants mess with you oh spike!” Sinbad called.

Peter wondered who was spike until he saw a huge mastiff run up to the 2 he sat on his back legs and panted.

“Spike meet your new playmate!”sinbad announces.

”Wait what is that dog gonna do to me!?”

sinbad pet spike on the head.

”don’t worry he’s just gonna give you dog kisses have fun!” Then sinbad walked away.

with that spike jumped on peter his paws on his shoulder and licked his face and cheeks sending slobber everywhere with peter laughing.

”HAHAHAHAHAHAHAHA good boy!!!”

Then spike took his licking up a notch so he started giving big licks to Peter’s face and often his chin sending slobber everywhere.

”HAHAHAHAHA oh my god this tickles so much!!!”

Then the dog tackled the non-aging teen to the floor of the ship and started licking his face cheeks and chin which muffled Peter’s laughter.

“HAHAHAHAHAHAHAHA so much slobbery love!!!”

Then spike finished of peter by licking his cheeks face and chin launching slobber everywhere and the teen’s laughter being muffled by the dog’s giant tongue licking his face.

this went on for a while until peter passed out with spike still licking his face.

then sinbad returned and pulled spike off of peter then told him to got to bed.

sinbad looked at peter and saw that his face was covered in slobber.

"Looks like you had fun."

Peter took in deep breaths as he continued to laugh.

"Hahahaha! Yeah. I've never met a pirate like you before, Sinbad. Maybe you and I could team up and fight my old enemy: Hook."

"I'll put that on the top of my list."

"Wait! I bet my friend Wendy would love to meet you two... especially Spike."

"Ok, who's Wendy?"

Peter explained to Sinbad that Wendy Darling is a good friend and she not only believed in him, but she was the one who told all his stories to her brothers: John and Michael. And sometimes, whenever Peter needed their help, he would whisk them away to Neverland. And with that, Tinkerbell sprinkled the whole Chimmera with pixie dust and the ship lifted into the sky. With Sinbad at the helm, he told his crew to set a course for London and off they went.

TO BE CONTINUED
Nana II and Jane Darling

In the darling mansion Jane darling was laying in bed reading a book with nana sleeping beside her bed.

When she finished the book she was reading jane got an idea “I’m gonna play with nana 2 for a while.”

So she got out of bed and squatted and started petting nana trying to get her too wake up.

”Time to wake up girl.” She whispers in the dogs ear.

Then nana 2 woke and saw her owner’s face so she licked her face then sat on her back legs and panted.

”Aww good girl so do you want to give me kisses?” She asked the dog.

As a yes the dog jumped on jane placing her paws on her shoulders and making use of her giant pink tongue started licking up Jane’s cheeks slurping them up in sprays of drool as the girl laughed.

All jane could see was nana 2’s big tongue covering her entire face.

”AHAHAHAHA I guess the that’s a yes!!”

Nana 2 started licking Jane’s cheeks and face and often her chin as the girl’s laughter is muffled by nana 2 licking her face.

”HAHAHAHAHAHA good girl very good girl!!!”

after several minutes of nonstop licking nana 2 decided to increase the speed of the licking of jane face cheeks and chin sending slobber everywhere.

after several more minutes nana 2 tackled Jane to the floor and gave her even more super slobbery kisses sending slobber everywhere and Jane laughter being once again muffled.

“HAHAHAHAHAHAHAHA”

Nana 2 increased the speed of her licking slurping up Jane entire face with slobber flying everywhere.

”HAHAHAHAHAHAHAHA Good girl!!”

after even more minutes of nonstop licking Jane decided she had enough of having nana 2 licking her.

”Okay girl that’s enough for tonight time for bed!!”

Nana 2 obeyed and got off of Jane and laid down then feel asleep.

jane giggled and wiped her face then kissed nana 2 on the head then got into bed.

”Good girl.”

then Jane went to sleep.
Beethoven (LA) and Peter Pan

Peter Pan was flying around London until a thought came into his head.

”well since I got licked by nana 2 I wanna see what another dogs got in terms of licking.”

so peter flew to the London kennel and walked inside and asked the receptionist if he could see a list of the dogs in the kennel.

He looked at it then selected ”beethoven”.

The receptionist gave him the key to his beethoven room and smiled.

”Room 21345 have fun.”

with that peter started looking for the room.

”Finally found it.”

peter used the key and opened the door to reveal a Saint Bernard playing with a ball.

”He there boy my name is peter you’re beethoven right nice to meet ya!”

With that he was immediately tackled by the dog and Beethoven started licking his face and cheeks covering his face with his giant tongue.

” HAHAHAHAHAHAHAHA good boy!!”

after a while beethoven licked away at his face covering his entire face with slobber.

”HAHAHAHAHAHAHAHA good boy very good boy!!”

after a while beethoven got off of peter and sat on his back legs panting.

Peter then started scratching him and the head and ears.

”Wow you’re way more friendly then nana 2 was.”

Beethoven then jumped on peter putting his paws on his shoulders and slurping his face and cheeks sending slobber everywhere.

After a while bee tackled peter again and started licking his face covering it in large amounts of slobber.

after a while peter passed out with peter still on him licking his face.

then beethoven got off of peter and went to sleep.
Max and Taran

video File:Placeholder

Taran practiced his swordsman ship with a stick on the beach.unknown to him his loud dramatic swinging got the attention of a big hairy English Sheepdog who inspected the noise and found a boy on the beach. The big dog sniffed the air and smacked his lips before letting out a loud bark and excitedly charge toward his new playmate.

Taran heard the barking and turned to see a hairy dog charging him. Instead of running, Tarzan chose to hold his ground and point his stick at the dog. “Stay back beast! Or I swear in my king’s name I shall OOOF!”
Max and Peter Pan

Max the sheepdog pet of prince Eric was on a walk on the beach enjoying the breeze flowing through his fur he kept on walking through the sand until he smelled something he has not smelled before fairy dust. Max was confused so he kept following the scent.

Peter pan was laying down on the beach cloud gazing.

”Ah this is a nice break from taking down mean old hook.”

what Peter doesn’t know is that something had found him lying down on the beach this creature was max who followed the fairy dust to the location of Peter when max the boy he wanted to greet him so the sheepdog trotted over to him.

As Peter was relax on the beach with his eyes closed until he felt something breathing on him.

”Huh?” Peter sat up and looked around until he came face with max, peter was surprised at first but then he realized that whenever he flew he left fairy dust behind so any kind of creature with a good sense of smell could find him instantly,

”Well hi there boy!” He started petting max and scratching him behind his ears until he found the dogs name tag and read It.

“So your name is max huh nice name my name is Peter Pan!”

Max then jumped on peter and started licking his cheeks and face coating them with slobber.

”HAHAHAHAHAHA good boy very good boy!”

Max then started licking his cheeks and face more excitedly sending slobber everywhere

“HAHAHAHAHAHA god your friendly!!!”

Max then tackled peter to the sand and starting licking peter face and cheeks even more excitedly sending slobber everywhere.

”HAHAHAHAHAHAHAHAHAHAHAHAHAHA” Peter screamed with laughter as max licked away at peter young face creating a puddle of slobber beneath the two.

after several hours of max nonstop licking of peter entire face until peter passed out on the sand.

when max realized peter was passed out Max then got off him and then trotted back to the castle were he would take a great nap after what happened today.
Beethoven (LA) and Mowgli

One morning, Mowgli, the Man Cub was walking through the park. He wasn't bothering anybody, aside from the squirrels and the birds he would often say hello to. But, hearing the birds tweet was music to his ears. It wasn't as good a chorus as the many birds in the jungle, but still good in his opinion.

As he was walking along, A St. Bernard was resting nearby until he suddenly got a strange whiff in his nose. He could tell right away that it was a boy, so he sat up and proceeded to follow Mowgli as quietly as he could. He followed him all the way to a giant oak tree, and that's when Mowgli heard the dog panting. He turned around and saw the St. Bernard standing there panting with his big tongue hanging out of his mouth. Mowgli thought this was the coolest, and most interesting looking dog he had ever seen. And, since he grew up with wolves, he was always willing to make a new friend.

"Hey, boy. Have you been following me?" The St. Bernard didn't give Mowgli an answer. He was waiting for his moment. "Are you all alone here?" asked Mowgli. There was still no answer. "Well, it's nice to know we're both not alone. It's always more friendly if you have someone to spend time with." The big St. Bernard took that as the signal and started running towards Mowgli. In Mowgli's past experiences with his wolf family, that usually meant he wanted to play. "Hey, that's right! Come here, boy! Come Here!" Mowgli held out both his arms ready for what was gonna happen next. The St. Bernard lept into the air and tackled Mowgli against the tree. The big dog then gave mowgli a huge lick up his right cheek. He then repeated this motion several times, sometimes dragging his big tongue up his left cheek as well.

"Hahahaha! Wow. That's some tongue you've got." joked Mowgli as he laughed. This St. Bernard wanted to show off his tongue even further, so he picked up the pace on his licking, each one covering up either Mowgli's whole face, or just one of his cheeks. With each and every lick, Mowgli's cheeks bounced, which felt ticklish nonetheless. "Hahahahahaha. Awe, I love you too, boy." Mowgli wrapped his arms around the big dog and started ruffling his fur. This only made the St. Bernard lick Mowgli even faster. So much so, that Mowgli ended up being knocked onto his back, to the side of the tree. "Hahahaha. Hey! Hahahahaha!! Ok, ok. Cut it out, for a sec, boy." The St. Bernard stopped licking Mowgli and let him sit up. As soon as the man cub did, he wiped his face clean. "Hahaha. Well, it looks like i made a new friend. What's your name? I'm Mowgli." Mowgli felt around in the dogs fur until he found a collar. "Bee-tho-ven? Hmm, i don't think i pronounced that just right." Beethoven gave Mowgli's face a few licks in sympathy to tell him to try again. "Haha. Yeah, you're right. I'll try again. Let's see... is it... "Bay-to-ven?" Beethoven barked twice before starting to lick him to death again. "Ahahahahahahaha!!! Hey, thanks, boy. I'm proud of myself too."
Baku and Genki (Monster Rancher)

Genki walked through the forest with an unease expression. He wasn't scared if any hostile monsters attacked (he could deal with that easily, thank you very much) but he came here to check on Baku. All the discs were supposed to be revived but he was still worried about Baku.

What if his disc got tampered with by one of Moo's remaining servants, what if there was an accident and Baku's couldn't be revived? What if-

Genki shook his head to ward off any negative thoughts. While he had every right to be worried about Baku, he couldn’t just dwell on the negative thoughts too much, otherwise he’d likely just make things more complicated than they needed to be.

Besides, it was like Holly (whom he was to meet up with at the manor) said, Baku was a survivor!

Genki heard rustling coming from the bushes. When he turned toward it, he was met with a large tongue to the face and was pinned down to the grass. The boy looked up and grinned at his ‘attacker’.

It was none other than Baku.

“I see it didn’t take too long for him to find you!” Holly said as she appeared to Genki, walking up and patting Baku on the side of the head.

Baku barked in confirmation before nuzzling his large head into Genki’s stomach, making him laugh.

“You sent him out to hunt me didn’t you?” Genki said, scratching under Baku’s chin.

”Yep, Baku show him how much you miss him.” Holly said.

\*Smack\*

Genki grinned boyishly as the dog-like monster’s tongue pressed itself against the right side of Genki’s face, slowly rolling the skin of it upward to the point of completely covering his eye. Genki tried to push Baku's head away but Baku was too strong and big to be pushed by Genki's small protesting hand.

"Baku, stop! Sit! Sit!" Genki tried to command but Baku refused to stop, as he started dragging his massive tongue over Genki's other cheek.

"Have fun with you're friend, Baku." Holly said with a grin before turning around to walk away.

"No don't leave me alone here!" Genki laughed as he tried to fend off Baku's slobbery affection.

Genki tried to raise his arms to block Genki’s tongue but his arms had been pinned down only thing he could do was turn his head. He couldn’t help but giggle when the tongue dragged across his ear.

”Come on, boy. Let me go.” Genki laughed.

Baku stopped licking and simply panted happily down at him with his tongue out. Genki let out a relieved sigh as he thought it was over.

That was until Baku gave him one big, extra slobbery lick right across his face from chin to forehead. When it flicked off, the front of Genki’s hair that popped out from under his cap was slicked upward.

Baku then got off the kid, who got up while grinning. Genki then wrapped his arms around Baku’s head and rubbed his cheek up against the monster dog.

It was a soaking price to pay but he would make a habit of visiting the big lug.
Max (The Little Mermaid)

Max is one of the most lovable sheepdogs you could ever meet. He’s always looking for a new playmate, young boys especially since they’re the only ones that can match his energetic personality. Of course, tasting the best whenever he licks them to unconsciousness is a major plus in his book. Once Max finds a new friend he’ll stick to them like glue as long as he feels wanted.
GLUT1-DS

fallo de la energía cerebral y una condición clínica denominada síndrome de
 deficiencia de GLUT1 (GLUT1-DS). Las características clínicas
 generalmente incluyen retraso del desarrollo motor y mental, convulsiones con inicio infantil, desaceleración del crecimiento de la cabeza que a menudo resulta en microcefalia adquirida y un trastorno del movimiento con ataxia,distonía y espasticidad. Posteriormente a la delineación de este fenotipo clásico, se reconoce la variabilidad de los signos y síntomas en GLUT1-DS.

Dentro de la familia de transportadores de glucosa facilitadores que comprenden 13 proteínas (símbolo de gen *SLC2A* ,símbolo de proteína GLUT), GLUT1 fue el primer miembro identificado, y en 1985 *GLUT1 / SLC2A1* fue el primer gen que se clonó y secuenció. El gen se encuentra en el brazo corto del cromosoma 1 (1p34.2), tiene una  longitudde 35 kb y consta de 10 exones. GLUT1 se expresa de forma constitutiva en la mayoría de los tejidos y se expresa selectivamente en eritrocitos, microvasos cerebrales y astroglia. Dos formas moleculares distintas de GLUT1 con pesos moleculares de 55 y 45  kDa difieren solo en el grado de glicosilación. Los 55 La forma kDa se encuentra predominantemente en las células endoteliales de los microvasos y eritrocitos del cerebro, donde es el principal transportador de glucosa (si no exclusivo). La forma de 45  kDa se detecta en la mayoría de las células, incluidos los astrocitos, y puede ser responsable de la captación de glucosa basal en estos tejidos. GLUT1 es una proteína de membrana integral de 492 aminoácidos con extremos amino y carboxilo intracelulares y 12 dominios transmembrana, que abarcan la membrana plasmática como hélices α (H1-H12). Presumiblemente, dos mitades del dominio 6-helicoidal están separadas por el gran bucle intercelular entre las hélices 6 y 7. La estructura tridimensional postulada se caracteriza por un canal central a través de la proteína que está esencialmente formado por las hélices 2, 4, 5, 7, 8, 8 , y 10 y conecta los ambientes extracelular e intracelular. Sólo se propone una apertura en cada extremo. Los dominios cruciales para el transporte y la patogenicidad se agrupan en dos grupos: uno alrededor del canal central y el otro en el bucle intracelular largo. La proteína GLUT1 aberrante puede resultar del truncamiento debido a mutaciones de cambio de marco, alteración de los sitios de unión del sustrato debido a mutaciones de sentido erróneo o ausencia de proteína debido a la eliminación del alelo. En todos los casos, el alelo normal contribuye con aproximadamente el 50% de la proteína GLUT1 funcional a la membrana plasmática. La mayoría de *las* mutaciones de *SCL2A1* detectadas ocurrieron *de novo* ,en casos familiares la condición se hereda como un rasgo autosómico dominante.

62. Brockmann
K. The expanding phenotype of GLUT1-deficiency syndrome. Brain Dev 2009;31:545–52
Spike and Wendy Darling

Sinbad, the legendary sailor and thief was walking through the streets of London with his trusty dog: Spike. They had been given explicit instructions to find Peter Pan's friend Wendy Darling. At last, they came across Darling Manor which is the corner house that Peter Pan chose because Wendy and her two brothers: John and Michael believed in him. But their target was Wendy. "Alright, Spike. Here's the plan. Once we get in, you go and find Wendy, but take this so that she thinks it's Tinker Bell." Sinbad gave Spike a bracelet of jingling bells and Spike took it in his mouth. "Ok, once Wendy's out of the house, bring her to Tavistock Square Gardens. Once you bring her there, that's when we give her the big "Surprise"". Sinbad explained. Spike knew exactly what his master was talking about, it was nothing short of a clever plan, which he was so famous for formulating.

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Grey Brother & Sura and Boy (The Small One)

The boy was walking through the forest, he was on his break but he didn’t know what to do in the forest. A twig snapping made him stop and look around cautiously. It didn’t appear to be anything nearby.

he was about to resume his walk when two big wolves leaped out of the bush and tackled him to the ground. The boy was about to scream in terror but he found himself laughing as his cheeks were slurped by the big wolf duo.

The boy’s face scrunched up as his cheeks were rolled upwards.
Beethoven (LA) and Billy

Billy bob was walking home eating a bag of cookies leaving crumbs on the road.

Beethoven the Saint Bernard was walking around the city until he came across some cookie crumbs on the road so he ate the trail of crumbs until he came across a boy with a bag of cookie in his hands.

So he ran up to the boy and took the bag in his hands and started eating it...and the bag.

Billy yelled at the dog”Hey those are my cookies!”

He was too late to get his cookies back beethoven ate all the cookies and the bag.

Billy was sad to not finish his cookie but he then smiled”Well I guess I don’t mind sharing.”

Beethoven wanted to thank him for the cookie so he started running up to billy with his tongue hanging out.

Billy realized what the dog was doing and he stated waving his in front of his face”Wait no no no no no!”

But it was too late beethoven tackled billy to the ground and started licking billy cheeks sending drool everywhere and his laughter being muffled by the dog tongue.

”HAHAHAHAHAHAH I didn’t know you were friendly!”

Beethoven started giving him full face licks sending slobber everywhere.

”HAHAHAHAHAHAHAH wait boy stop please!”

Billy tried lightly pushing beethoven away so he could breath but that only spurred the dog on to give him faster more slobbery kisses which only made billy laugh harder and louder.

” HAHAHAHAHAHAHAHAHAHAHAHAHA!”

Billy finally lightly pushed him off him and sat up.

”Wow boy you are pretty friendly I wish I have you as a pet but my dad won’t allow...but he doesn’t need to know.”

Billy then look at the dog tag which had the name ”Beethoven“ written on it.

“So your name is beethoven huh well nice to met you boy my name is billy.”

Beethoven then tackled billy again and gave him super slobber kisses with billy laughter being muffled by his licking.

” HAHAHAHAHAHAHAHA wait boy I can’t get licked by you all day I gotta get home or else my dad gonna get mad and if I gonna have you as a pet I’m gonna have to keep you a secret.”

Beethoven gave him one more full face lick then got off of billy and sat on his back legs on panted.

Billy then petted him on the head then to beethoven home billy was excited to finally have a dog but he knew having is gonna be a big responsibility.
Luiz and Blu (Rio)

It was a beautiful day in Rio de Janeiro. Blu the blue macaw flew to Luiz's garage to visit him.

As soon as Blu looked inside he saw Luiz the bulldog sitting on top of the car's engine cover.

"Hi-ya, Luiz." said Blu.

"Hey, Blu!" shouted Luiz as he licked his nose, panted heavily and ran to Blu. He then hugs Blu, drooling all over his face and panting on him, letting his pink tongue out of his mouth.

"Ew. Gross," said Blu. Luiz then slurps his tongue slowly up Blu's cheek and flicks off in drool. "Totally gross!" Blu said.

Luiz said, "Aw, come on, Blu. That was my favorite part!" He continued panting with his tongue out.

"Okay, Luiz," answered Blu. "Give me good licks. Every lick on my face."

"Thanks, bro," said Luiz as he ran to the front of the car. He then said, "That’s gonna to be a good one. It’s gonna be a good one."

Then, he licks his nose again, barks and pants with his drooling tongue out again, drooling on the floor and charges to Blu.

Blu complies, "Luiz. Whoa, Luiz. Whoa. Whoa, whoa, whoa, whoa whoa WHOA WHOA WHOA WHOA! Hold it! Hold it!"

Luiz pounces on Blu and tackles him to the floor and gives him more slobbery licks, covering his entire face with his gargantuan wet tongue and soaking him in saliva.

Blu laughed, "Hahahahahaha! Cut this out, Luiz! Hahahaha! That tickles! Hahahahahaha!" He continued to feel Luiz's ticklish tongue.

Luiz then began licking Blu's entire face even faster, causing his face to get more soaked.

He licked his face faster and faster and faster until he gave him the biggest slobbery lick on his entire face and flicked off with a drool.

Finally, Luiz stopped the slobbery affection and Blu laughed, feeling Luiz's saliva on his face.

"I love being licked by you," said Blu.

"You can say that again," said Luiz.
Tiger & Talbot and Ben Tennyson

The tiny alien known as Grey Matter was traveling through the vents as he navigated through the vents. He snuck into King Arthur's castle to get a good look at the young King's crown. He may be a hero, but he was no saint. He was going to put it back when he was done, though.

Soon, the tiny alien found the room that displayed the crown on a cushion. He exited the vent and dropped to the floor.

He froze when he heard something growling behind him. He turned around to find a Great Dane with drool dripping from his sharp fangs.

"Um, nice dog!" Grey Matter said nervously with a grin as he stepped back, the followed him with each step.

Then he heard another growling and turned to find an equally pissed off Great Dane growling furiously at him.

"Um, are you King Arthur's dog? I love dogs, I have one back at home! I wasn't going to steal that crown, I was just going to wear it- b-but I was going to put it back! But now, how about I just leave!" As Grey Matter rambled on, the Omnitrix symbol on his back started beeping red. The whole room flashed green, instead of a tiny alien there was a regular human 10-year-old boy.

Tiger and Talbot were puzzled to find the tiny intruder replaced by an ordinary human child. The two dogs shared a look of confusion before deciding to investigate this intruder further to find out if he was dangerous.

Ben was worried as he feared he wasn’t going to escape easily now that he’s human again. The two big dogs approached him and began to sniff his face, his hair, his stomach, his shoes, his arms, his ears, everywhere. It made Ben giggle but he didn’t want to attract he guards so he pushed two dogs away by their snouts. Or tried to at least because these dogs were strong and Ben was only ten.

His giggling had made Tiger and Talbot happy as they loved the sound of potential playmates laughter. When the young boy tried to push them away the two stopped and stared at one another. There confused expression turned into mischief as they turned back to the Ben and had their tongues panting out.
Tiger & Talbot and Ash Ketchum

Ash was hiding behind one of the bushes, trying to find a large Pokémon he could train. Misty was still at their campsite asleep and he didn't want to disturb her so he went alone. Besides he wasn't alone he had his pokeballs with his beloved Pokémon inside, except Pikachu who was also still at camp.

Tiger and Talbot were sniffing the ground on the hunt for that squirrel they had lost, but soon a new scent entered their nostrils. The two equally large Great Danes wagged their tails and bounded at top speed toward theit target.

Ash was getting bored, he had waited for almost an hour and still no Pokémon had appeared. He was about to head back until he heard the bushes around him moving.
GLUT 5 transportador principal de fructosa

GLUT5 se encuentra en muchos tejidos, y su expresión y actividad están claramente reguladas en condiciones normales y están alteradas en condiciones patológicas.

GLUT5 se expresa solo en un número limitado de tejidos que parecen ser capaces de metabolizar la fructosa o preferentemente, y existen dos categorías principales de regulación transcripcional y / o postranscripcional de GLUT5. En la membrana apical de las células polarizadas (por ejemplo, enterocitos y células renales), GLUT5 está regulado de forma aguda y específica por su propio sustrato, mientras que en los otros tejidos, como los adipocitos, la fructosa no parece tener ningún efecto agudo

En roedores, vacas y caballos, la
distribución de GLUT5 es mayor en la zona proximal (duodeno y yeyuno proximal) en comparación con los segmentos distales (yeyuno distal e íleon).

En condiciones normales, en los períodos prenatal y de lactancia del desarrollo de ratas, conejos y humanos (14 días en roedores), los niveles de ARNm GLUT5 intestinal y las tasas de transporte de fructosa son muy bajos (Fig. 1).

El consumo de miel y jugo de fruta que contiene mucha fructosa provoca un aumento marcado en el aliento de hidrógeno (un marcador de malabsorción de carbohidratos) en niños menores de 1 año de edad, pero no en aquellos de 2 o más años, lo que sugiere malabsorción intestinal inducida por fructosa en niños muy pequeños humanos posiblemente expresando bajos niveles de GLUT5.

La fructosa se transporta de
forma pasiva a través de las membranas por un miembro de la familia del transportador de glucosa facilitador (GLUT), denominado GLUT5.  Entre los siete miembros capaces de transportar fructosa, GLUT5 es el único transportador específico para fructosa sin capacidad para transportar glucosa o galactosa.

Hoy en día, la cantidad de fructosa consumida cada día varía de 8 a 100 g, y el promedio es de 80 g. La mayor parte del aumento en el consumo se deriva de la fructosa refinada o procesada conocido como jarabe de maíz con alto contenido de fructosa. La fructosa es el más dulce de todos los azúcares naturales, y esta es la razón principal por la que la glucosa se convierte en fructosa y en el uso de HFCS en la formulación de productos de alimentos y bebidas.

Referencia: Douard V, Ferraris RP. Regulation of the fructose transporter GLUT5 in health and disease. Am J Physiol Endocrinol Metab 2008;295:E227–37.
Tiger & Talbot and Sora (Kingdom Hearts): A Bath for a Keyblade Bearer

Sora groaned as he scrubbed himself in King Arthur's luxurious tub. There was a malfunction with the gummi ship which caused it to crash. Sora was fine but as soon as he exited the ship, he fell and crashed into the mud below.

Sora came across Arthur who took pity upon the mud-covered teen and took him to his castle where he could wash up. Once he finished cleaning his ears of mud, he dried and got his clothes. Now there was another problem, the castle was so big that he didn't know where to go.

He walked around, Arthur had to be around here somewhere. He opened one door and saw that the room appeared to be vacant. There were hooks on the wall that held leaches and two big dog bowls in the middle.

Sora decided to enter and close the door behind him. As soon as it closed, Ryan heard claws clicking on the floor as two huge Great Danes charged him.
Bee(dragon ball) and Hiro Hamada

Hiro Hamada went to the city square of San Fran Sokyo to meet hercule satan.

"Mr Satan!" He walked to the man and held out his hand.

"Can you shake my hand please?"

"Hahaha sure son anything for a fan."

He then shook hiro hand a said"Hey would you like to meet my pet dog?"

Hiro nodded.

"Okay then come with me."

Hiro got into Hercule limo and they drove back to his house Hercule opened the door and went inside.

When they got inside he yelled out."Bee I'm home boy!!"

After that hiro heared barking then he saw a golden retriever running towards them.

The dog then stop then sat on their back legs panting with their tongue hanging out.

"This is bee say hi to hiro!"

Hiro knelt then started petting bee on the head.

“Hey there bee how you doing?”

Bee then jumped on hiro putting his paws on his shoulders and licking his face covering it in slobber.

" HAHAHAHAHAHAHAHA good boy!"

Bee then tackled hiro to the floor and licked away at him sending slobber and muffled his laughter with his tongue.

Bee then increased the speed of his licking of hiro face and often his chin slurping it all off in a spray of slobber.

" HAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHA!!!"

After a while bee got off of hiro and sat on his back legs panting.

Hiro got up and wiped his face of the slobber.

But Bee didn’t want hiro to be clean yet so he tackled hiro again and slobbered all over his face.

Hercule laugh and said”Wow bee must really like you hiro!”

”HAHAHAHAHAHAHAHAHAHAHA he sure does!”

Bee increased the speed of his tongue slurping up hiro entire face sending huge amount of slobber flying everywhere.

After a while bee finally got off hiro then went back to their room for a nap.

Hiro wiped his face of all the slobber then stood up with a smile on his face.

”Well hiro I can tell that you had fun right?”

”Yeah I very much did.”

Hiro then looked at the and then rushed off but not before waving to Hercule.

“Bye mr Satan!”

Hercule waved back to hiro "Bye hiro hope to see ya next time I come by!"
Hercules (The Sandlot) and Scotty Smalls

Each of the Sandlot kids were tasked with taking care of Hercules for the weekend and now it was Scotty's turn.

The brown-haired boy entered Mr. Mertle's backyard. There was a time when they all used to be afraid of Hercules but now he was their beloved mascot and playmate. They had managed to get Hercules to learn how to shake, stay, sit, lay down, roll over, and even play dead. But one thing they hadn't been able to teach the big lug is something that Scotty got the worst of.

Hercules had been sleeping in his doghouse, with his head on his paws. His nostrils flared as he smelled his favorite playmate. Hercules immediately woke up and saw Scotty.

"Here, Hercules! C'mere boy!" Scotty said with a smile, as he patted his thighs. Hercules needed no more persuasion. He got up and bolted toward Scotty.

Scotty smiled as the large, English Mastiff charged at him with his tongue hanging out and drool dripping from his jowls but then his smile dropped as Hercules wasn't stopping. He raised his arms in defense.

"Hercules, wait! Stop! Sit! Sit!" Scotty tried to command but Hercules wasn't stopping. The big dog leaped into the air and tackled the boy to the ground.

Hercules had Scotty where he wanted him now. He stared at him happily, panting and Scotty knew what was coming next. "Alright boy, you got me." he said. Hercules then started licking Scotty's face several times. The boy scrunched up his face as the 'Beast's' slobbery tongue swiped from his chin to his forehead.

In the past, Scotty had tried to push Hercules's head away whenever the big dog decided to give him slobbery kisses but this did not work because Scotty was hardly a strong kid. Heck, his efforts seemed to make Hercules even more excited and douse him in even more dog saliva.

So now, Scotty always resisted pushing him away and decided to just take it, no matter how ticklish Hercules's tongue was or how bad Hercules's breath stunk.

After a while, Hercules had finally stopped and simply kept the boy pinned underneath him as he panted happily and stared adoringly at his favorite boy.

Scotty unclenched his face and winced as he was able to move one arm and wipe some of the sticky saliva off with the back of his wrist.

"Are you finally done, boy?" Scotty joked.

Hercules answered by barking loudly.

**Trivia**

• This is based on the film.
Hercules (The Sandlot) and Lincoln Loud

Lincoln was surprised being approached by the Sandlot crew and even more surprised that they needed his help with something. Apparently their newest member, Smalls brought a baseball sighed by Babe Ruth and it got hit over the fence to the 'Beast's' territory and they needed 'The Man with The Plan' to retrieve it. Lincoln was familiar with the Beast story and if Lincoln was honest, he thought the story was ridiculous.

He was promised 20 dollars from each of the sandlot crew, so that's why Lincoln climbed the fence and dropped into the Beast's den.

He immediately found the baseball signed by Babe Ruth in the dog house where the Beast slept. But the large dog was nowhere to be found. He headed toward the dog house and bent down to pick up the valuable baseball. He was immediately disgusted as the ball was covered in dog slobber, but he had the ball now. He wasn't sure if it was still valuable because of all the drool. But the Sandlot crew still owed him!

He turned around still crouched and found himself face to face with the slavering jaws of an English Mastiff. Lincoln was suddenly struck with fear, he wasn't expecting the dog to be this big.

"Um, nice doggy." Lincoln said, nervously. The big dog continued to slobber, eyeing the boy intently.

Lincoln got the idea and chucked the ball high in the air. "Fetch!"

The Beast's head immediately swirled in the direction of the ball before bouncing toward it, barking excitedly and forgetting the intruder.

Lincoln took this opportunity to run for the fence. Hercules turned back with the ball in his dripping jaws and found the boy running. Hercules dropped the ball and bounded after the boy who wanted to play Chase instead.

The boy didn’t get fat as Hercules tackled him to the floor and nosed him on to his back. Then Hercules did what he normally did to the Sandlot Kids, especially his best friend Smalls.

He proceeded to give the boy’s face a thorough wash with his slobbering tongue.

Lincoln closed his eyes and mouth tightly as a rough and wet tongue was dragged up his face from chin to forehead. He was no stranger to big dogs thinking his face needed a bath but that didn’t mean he liked having to wash the sticky stuff off his face. It was gross!
Tiger & Talbot and Sora (Kingdom Hearts)

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Sora ran through the forest as he was chased by two Great Danes named, Tiger and Talbot. The the young teen didn't know what happened, first he landed in a new world then he found some seemingly nice guy named Arthur, then he was chased by the two hunting dogs. The only reason he hadn't drawn his Keyblade was because he didn't want to hurt the two dogs.

The spiky, brown haired teen found himself in a rocky dead end and was immediately pounced by the two dogs. Instead of screams their was laughters as both dogs began licking his face.

"Hey, stop that!" Sora protested, scrunching his face up as both Tiger and Talbot dragged their tongues across his face.
Beethoven (LA) and Cody (The Rescuers Down Under)

Cody was laying on his stomach with his elbows on the dirt ground and his cheeks resting on his hands as he watched a line of ants. The blond boy was startled as two paws landed right in front of him, followed by panting and droplets falling on to the ants, making them all scatter in various directions. Cody got on his knees to find himself face to face with a Saint Bernard dog.

"Woah, where'd you come from?" Cody asked as he grabbed the dog's collar and took a look at his nametag which read, 'Beethoven.'

SLUUURP!

Cody was met with a slavering tongue upon his cheek which forced him to close one eye while his other eye widen in surprise.

"Hey!" Cody protested though he couldn't help but giggle.