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Los Angeles (US: /lɔːs ˈændʒələs/ (listen) *lawss AN-jəl-əs*; Tongva: *Tovaangar*; Spanish: *Los Ángeles*; "The Angels"), officially the City of Los Angeles and often abbreviated as L.A., is the largest city in California. It has an estimated population of nearly 4 million, and is the second-largest city in the United States, after New York City, and the third-largest city in North America, after Mexico City and New York City. Los Angeles is known for its Mediterranean climate, ethnic and cultural diversity, Hollywood entertainment industry, and its sprawling metropolitan area.

Los Angeles lies in a basin in Southern California, adjacent to the Pacific Ocean, with mountains as high as 10,000 feet (3,000 m), and deserts. The city, which covers about 469 square miles (1,210 km2), is the seat of Los Angeles County, the most populous county in the United States. The Los Angeles metropolitan area (MSA) is home to a population of 13.1 million, making it the second-largest metropolitan area in the nation after that of New York. Greater Los Angeles includes metro Los Angeles as well as the Inland Empire and Ventura County. It is the second most populous U.S. combined statistical area, also after New York, with a 2015 estimate of 18.7 million people.

Home to the Chumash and Tongva, the area that became Los Angeles was claimed by Juan Rodríguez Cabrillo for Spain in 1542. The city was founded on September 4, 1781, under Spanish governor Felipe de Neve, on the village of Yaanga. It became a part of Mexico in 1821 following the Mexican War of Independence. In 1848, at the end of the Mexican–American War, Los Angeles and the rest of California were purchased as part of the Treaty of Guadalupe Hidalgo, and thus became part of the United States. Los Angeles was incorporated as a municipality on April 4, 1850, five months before California achieved statehood. The discovery of oil in the 1890s brought rapid growth to the city. The city was further expanded with the completion of the Los Angeles Aqueduct in 1913, which delivers water from Eastern California.

Los Angeles has a diverse and robust economy, and hosts businesses in a broad range of professional and cultural fields. It also has the busiest container port in the Americas. In 2018, the Los Angeles metropolitan area had a gross metropolitan product of over $1.0 trillion, making it the city with the third-largest GDP in the world, after Tokyo and New York City. Los Angeles hosted the 1932 and 1984 Summer Olympics and will host the 2028 Summer Olympics.

Mexican rule ended during the Mexican–American War: Americans took control from the Californios after a series of battles, culminating with the signing of the Treaty of Cahuenga on January 13, 1847.

Railroads arrived with the completion of the transcontinental Southern Pacific line from New Orleans to Los Angeles in 1876 and the Santa Fe Railroad in 1885. Petroleum was discovered in the city and surrounding area in 1892, and by 1923, the discoveries had helped California become the country's largest oil producer, accounting for about one-quarter of the world's petroleum output.

By 1900, the population had grown to more than 102,000, putting pressure on the city's water supply. The completion of the Los Angeles Aqueduct in 1913, under the supervision of William Mulholland, ensured the continued growth of the city. Because of clauses in the city's charter that prevented the City of Los Angeles from selling or providing water from the aqueduct to any area outside its borders, many adjacent cities and communities felt compelled to join Los Angeles.

Los Angeles created the first municipal zoning ordinance in the United States. On September 14, 1908, the Los Angeles City Council promulgated residential and industrial land use zones. The new ordinance established three residential zones of a single type, where industrial uses were prohibited. The proscriptions included barns, lumber yards, and any industrial land use employing machine-powered equipment. These laws were enforced against industrial properties after the fact. These prohibitions were in addition to existing activities that were already regulated as nuisances. These included explosives warehousing, gas works, oil drilling, slaughterhouses, and tanneries. Los Angeles City Council also designated seven industrial zones within the city. However, between 1908 and 1915, Los Angeles City Council created various exceptions to the broad proscriptions that applied to these three residential zones, and as a consequence, some industrial uses emerged within them. There are two differences between the 1908 Residence District Ordinance and later zoning laws in the United States. First, the 1908 laws did not establish a comprehensive zoning map as the 1916 New York City Zoning Ordinance did. Second, the residential zones did not distinguish types of housing; they treated apartments, hotels, and detached-single-family housing equally.

Hill Street, looking north from 6th Street, c. 1913. Notable sites include Central Park (today's Pershing Square) (the trees, lower left), Hotel Portsmouth (lower right), and the Hill Street tunnel (at end of street).

In 1910, Hollywood merged into Los Angeles, with 10 movie companies already operating in the city at the time. By 1921, more than 80 percent of the world's film industry was concentrated in L.A. The money generated by the industry kept the city insulated from much of the economic loss suffered by the rest of the country during the Great Depression. By 1930, the population surpassed one million. In 1932, the city hosted the Summer Olympics.

During World War II, Los Angeles was a major center of wartime manufacturing, such as shipbuilding and aircraft. Calship built hundreds of Liberty Ships and Victory Ships on Terminal Island, and the Los Angeles area was the headquarters of six of the country's major aircraft manufacturers (Douglas Aircraft Company, Hughes Aircraft, Lockheed, North American Aviation, Northrop Corporation, and Vultee). During the war, more aircraft were produced in one year than in all the pre-war years since the Wright brothers flew the first airplane in 1903, combined. Manufacturing in Los Angeles skyrocketed, and as William S. Knudsen, of the National Defense Advisory Commission put it, "We won because we smothered the enemy in an avalanche of production, the like of which he had never seen, nor dreamed possible."

In the 1930s–1940s, Los Angeles county was the national leader in agriculture.

George Patton during a welcome-home parade in Los Angeles, June 9, 1945

Following the end of World War II, Los Angeles grew more rapidly than ever, sprawling into the San Fernando Valley. The expansion of the Interstate Highway System during the 1950s and 1960s helped propel suburban growth and signaled the demise of the city's electrified rail system, once the world's largest.

Racial tensions led to the Watts riots in 1965, resulting in 34 deaths and over 1,000 injuries.

In 1969, California became the birthplace of the Internet, as the first ARPANET transmission was sent from the University of California, Los Angeles (UCLA) to the Stanford Research Institute in Menlo Park.

In 1973, Tom Bradley was elected as the city's first African American mayor, serving for five terms until retiring in 1993. Other events in the city during the 1970s included the Symbionese Liberation Army's South Central standoff in 1974 and the Hillside Stranglers murder cases in 1977–1978.

In 1984, the city hosted the Summer Olympic Games for the second time. Despite being boycotted by 14 Communist countries, the 1984 Olympics became more financially successful than any previous, and the second Olympics to turn a profit; the other, according to an analysis of contemporary newspaper reports, was the 1932 Summer Olympics, also held in Los Angeles.

Racial tensions erupted on April 29, 1992, with the acquittal by a Simi Valley jury of four Los Angeles Police Department (LAPD) officers captured on videotape beating Rodney King, culminating in large-scale riots.

In 1994, the magnitude 6.7 Northridge earthquake shook the city, causing $12.5 billion in damage and 72 deaths. The century ended with the Rampart scandal, one of the most extensive documented cases of police misconduct in American history.

In 2002, Mayor James Hahn led the campaign against secession, resulting in voters defeating efforts by the San Fernando Valley and Hollywood to secede from the city.

Los Angeles will host the 2028 Summer Olympics and Paralympic Games, making Los Angeles the third city to host the Olympics three times.