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# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Sat Mar 28, 2015 02:28 AM
Quote | ReplyHas anyone tried to contact Dr Ko and get a response?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Sat Mar 28, 2015 02:37 AM
Quote | ReplyI am new to commenting on this thread--but have been avidly reading all of the wonderful information contained therein.

I have stage IV breast cancer with various mets and have a very good feeling about 3-BP.  However, I just do not have the funds to go to a clinic for care and am hoping that soon someone will provide appropriate methods--whether oral or i.v.--  for those who may not be able to travel or may have to treat at home.

Right now it seems that the clinics who are providing 3-BP have not been able to share their proprietary methods of administering 3-BP.  They must have their reasons--so patience is necessary--but time is of the essence for me and for many others.

In the meantime, hypercriticism, negativity, and fault-finding do not behoove any of the contributors on this message board--whether originating from physician, patients, or caregivers.

No doubt we are all under considerable strain--whether it stems from emotional, physical, or financial origins (and sometimes all three!) and we have many serious decisions to make.

Humor is indeed healing--but along the pathway of attempting to heal, I am sure many of us have encountered many promises and also arrogance from those we thought were going to help us through this morass.  So we are constantly sifting through any and all new treatments--and thusly we can become very serious and questioning.

I have read many of the comments here and they demonstrate such a deep level of compassion and caring.  Let us all continue to move forward with positivity, love, and sharing.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sat Mar 28, 2015 05:19 AM
Quote | ReplyIn that case you should be able to get the combi of Dentritic Cells and andti PD1 there om US. These are two vaccines that you can do at home. Just find a clinic that offers DC and you can buy yourself anti PD1. From what I undestood 1mg/kg anti PD1 should be enough.

Another serious option to check in US is Supportive Oligonucleotide Technique (SOT). In the US, there is an integrative practitioner, Dr Ray Hammon of Texas, who offers this treatment.http://www.atmctx.com/service/staff/

Thre are very positive results following this treatment but I think the tumors have tu be in general smaller than 2-3cm. But just check it to be sure. I think the price was below 10k for one year tretment (3 vaccines).
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sat Mar 28, 2015 05:21 AM

Quote | Reply

On Mar 27, 2015 10:27 PM zhaosr wrote:

Thanks, but she just had a chest drain inserted to relieve a malignant pleural effusion so won't be able to fly anywhere for a while. The oncologist says if she fails platinum doublet therapy started last week, there is nothing funded left. And there are no local trials recruiting. So, if 3bp has to be imported by myself, so be it. But I need data.
In that case you should be able to get the combi of Dentritic Cells and andti PD1 there om US. These are two vaccines that you can do at home. Just find a clinic that offers DC and you can buy yourself anti PD1. From what I undestood 1mg/kg anti PD1 should be enough.

Another serious option to check in US is Supportive Oligonucleotide Technique (SOT). In the US, there is an integrative practitioner, Dr Ray Hammon of Texas, who offers this treatment. http://www.atmctx.com/service/staff/

Thre are very positive results following this treatment but I think the tumors have tu be in general smaller than 2-3cm. But just check it to be sure. I think the price was below 10k for one year tretment (3 vaccines).
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### RE: Anyone used 3bp (3-bromopyruvate)?

by howardA on Sat Mar 28, 2015 10:02 AM
Quote | Replymorning zhaosr... am also sorry to here about your wife. but if you want to do 3bp at home there is no better way than a nebulizer especially for lung cancer  howard
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Mar 28, 2015 01:00 PM
Quote | ReplyIt terms of everyone getting to know each other, I was trying to (subtly) imply that some should read some of the back posts. Regular readers of the thread know who is associated with particular clinics etc. .

This thread has had a rocketing start to 2015! There have been over 20 pages of posts in March alone. Recently we have had posts from several new to the thread. Welcome.

As a suggestion, we might start a parallel thread for lurkers or groupies (or whatever) to post comments about how much they like our thread, general comments etc.. The intention would be to develop some sense of the audience this thread is attracting and to keep our thread focussed on 3-BP. From my understanding, this thread is perhaps one of the most active 3-BP on the net.

Another thing we could try is to setup a Google analytics dashboard for our thread. (We might have to go through the cancer compass administrators to do this). A Google  Analytics account would give us a bunch of information on this site. For example, how many visitors (unique and returning), what visitors click on, location of visitors,etc etc..

If the forum administrators allowed it, we could post the password to the Analytics account which would allow everyone on the thread to access the Analytics dashboard. We could then see the traffic to this site (in real time!),

This thread appears to be attracting a considerable following, it would nice to have this confirmed.

Any comments?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by adickens7 on Sat Mar 28, 2015 02:00 PM

Quote | Reply

On Mar 28, 2015 3:09 AM zhaosr wrote:

Thanks. I've read all the published papers, and the press release. Odd way though to publish. Most reputable institutions use journals to disseminate data.

As for Dayspring, color me unimpressed when they use boiler plate text on how many untreatable diseases they can treat, the lack of any named personnel on their website, and lack of publications to substantiate their claims.
One thing to be aware of is one's world view.  It is like going into a restaurant and the menu is unbelievable!  Fancy photos and the lay out, wow, is it incredible!!!  Very  impressive but when the food comes it is poison (chemotherapy) with a 98% negative rating.

So sorry if Dayspring's website is not up to expectations but we are a small cutting edge clinic.  When our "food" comes it is health and healing.  No, we do not have data however for a pancreatic to have a 20% improvement in tumor markers weekly (60% in three weeks) we are very impressed with 3bp.  All the while on 3bp appetite, hair and energy is maintained.

Another clinic is offering 3bp and perhaps their website is up to your expectations.  All the best to your wife's outcome.      http://beta.ensemba.com/view?resource\_id=2885591&topic\_i
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### RE: Anyone used 3bp (3-bromopyruvate)?

by tddelon24 on Sat Mar 28, 2015 02:08 PM
Quote | ReplyI agree And thank you for posting! We can all agree that we need a proven cure, that's what has brought us all together. Let's keep the message positive in that pursuit and support each other. 3 BP may not have the data behind it, but it appears to be working!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Sat Mar 28, 2015 02:19 PM
Quote | ReplyHoward, have you read this paper?

http://www.ncbi.nlm.nih.gov/pubmed/25644152

I only read the abstract. Will have to check if we can get rapamycin.

The thing that attracts me to 3bp is that she could try it as an adjunct treatment to her proposed chemo.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Sat Mar 28, 2015 02:33 PM

Quote | Reply

On Mar 28, 2015 5:00 PM Jcancom wrote:

It terms of everyone getting to know each other, I was trying to (subtly) imply that some should read some of the back posts. Regular readers of the thread know who is associated with particular clinics etc. .

This thread has had a rocketing start to 2015! There have been over 20 pages of posts in March alone. Recently we have had posts from several new to the thread. Welcome.

As a suggestion, we might start a parallel thread for lurkers or groupies (or whatever) to post comments about how much they like our thread, general comments etc.. The intention would be to develop some sense of the audience this thread is attracting and to keep our thread focussed on 3-BP. From my understanding, this thread is perhaps one of the most active 3-BP on the net.

Another thing we could try is to setup a Google analytics dashboard for our thread. (We might have to go through the cancer compass administrators to do this). A Google  Analytics account would give us a bunch of information on this site. For example, how many visitors (unique and returning), what visitors click on, location of visitors,etc etc..

If the forum administrators allowed it, we could post the password to the Analytics account which would allow everyone on the thread to access the Analytics dashboard. We could then see the traffic to this site (in real time!),

This thread appears to be attracting a considerable following, it would nice to have this confirmed.

Any comments?
Onnit MCT Oil | Onnithttps://www.onnit.com/onnit- **mct**-oil/A way to add ketones?All the medium chain fatty acids normally found in coconut oil, including caprylic acid (C-8), capric acid (C-10), and lauric acid (C-12) are known to have the advantage of being easily transported into the mitochondria and therefore more immediately available for energetic use and resulting in a burst of energy and thermogenesis.

Unfortunately, most purified MCT oils on the market forget about the longest carbon chain fatty acid and do not contain lauric acid at all, which means you’re losing out on one of the better medium chain fatty acids that are normally found in coconut oil.
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# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Mar 28, 2015 02:57 PM
Quote | ReplyI have deferred to the knowledge leaders on this thread, though I would like to comment on the 3-BP - rapamycin lung cancer article in mice.

I think it would be best to stay away from new combinations especially when starting out and particularly in the context of a heavy tumor burden. The liver cancer report showed that even with highly skilled doctors straight 3-BP treatment unexpected side-effects can result. Probably best to keep any 3-BP treatment to simple vanilla (as reported in the patents). Amping up 3-BP can result in serious complications such as Tumor Lysis Syndrome. Straight 3-BP is powerful.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Sat Mar 28, 2015 04:22 PM
Quote | ReplyAlthough dietary energy restriction and anti-glycolytic cancer drugs will have therapeutic efficacy against many tumors that depend largely on glycolysis and glucose for growth, these therapeutic approaches could be less effective against those tumor cells that depend more heavily on glutamine than on glucose for energy. Glutamine is a major energy metabolite for many tumor cells and especially for cells of hematopoietic or myeloid lineage. Glutamine metabolism can be targeted in humans using the glutamine binding drug, phenylacetate, phenylbutyrate or the glutamine analogue DON (6-Diazo-5-oxo-L-norleucine). Toxicity, however, can be an issue in attempts to target glutamine metabolism using DON. Recent studies suggest that the green tea polyphenol (EGCG) could target glutamine metabolism by inhibiting glutamate dehydrogenase activity under low glucose conditions. Phenylbutyrate is metabolized to phenylacetate and binds to glutamine and this is eliminated via the urine so could be used. That said other amino acids could be used, so a low to moderate protein intake would help also on this diet. The dosage for 2DG is 30-40mg/Kg and phenylbutyrate is 3-5g/day. Other drugs like DCA, 3BrPA should also be used (most of us know this). There are also many other drugs/supplements that could be helpful too. Omega 3 fatty acids can reduce the cachexia phenotype and help with maintaining low glucose levels and elevate ketone levels. With 3BrPA it knocks out both sources of ATP, so you may not need a glutamine binding drug
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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Sat Mar 28, 2015 04:38 PM

Quote | Reply

On Mar 27, 2015 9:20 PM zhaosr wrote:

My wife has stage 4 lung cancer which is rapidly advancing, and resistant to tyrosine kinase inhibition. We are looking for high quality data.

I note that you're not a physician. But if your naturopathic clinic has good data, you should share it. The fact that you don't likely means you don't have the data.
I am sorry to hear about your wife, the diet can be hepful and in combo with other drugs better still. PDT could also help too http://www.ncbi.nlm.nih.gov/pubmed/16794636  and ideally immunostimulants should be used with it. With GM-CSF http://www.ncbi.nlm.nih.gov/pubmed/8764122/  and GcMAF http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063270/  http://www.saisei-mirai.or.jp/gan/pdf/20131207-presentation-  http://www.saisei-mirai.or.jp/gan/pdf/20140629-indications-g  There are others as well, if this generates tumor infiltrating lymphocytes then a anti-PD1 may be needed, using an anti-CTL4 along with it should have a synergistic effect
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Sat Mar 28, 2015 04:44 PM
Quote | Reply@Jcancom

The child with the tumor lysis syndrome had the drug delivered directly via the hepatic artery, and their liver was severely compromised so he also developed an encephalopathy.

The reason that nebulised 3PB seems attractive is that it will allow bypassing first pass liver metabolism, and the drug can be delivered directly to the tumors via the bronchial arteries, and systemic circulation.

I have seen various people reporting that 3BP is not enough by itself which is why I mentioned the Rapamycin ( rather then indirectly targetting mTor via Metformin ).  However, I take your point that TLS is a possibility with large tumor load, and my wife's lung lesion is over 8 cm, with many other smaller metastases.  You now have me worried about giving this to her at home without the ability to rapidly monitor her electrolytes, and uric acid.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Sat Mar 28, 2015 04:48 PM
Quote | Reply@james-peters

Unfortunately in NZ, we don't have access to check point inhibitors.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Mar 28, 2015 05:33 PM
Quote | ReplyI am not sure whether the liver patient received the best medical care. The doctors seemed surprised by the TLS that emerged after the second dosing round that was expected to be fatal. (However, the article mentioned that TLS might present in an unusal way in this specific type of cacner). 3-BP was pushed relentously at the patient which resulted in liver collapse and the patient's demise. An idea they might have used was treating with a cancer stabilizer (e.g. IV DCA) after a few rounds of 3-BP, in order to allow the patient  build up strength. The picture from the artilce shows a healthy teenager on this September birthday, though his liver collapsed in December after about the tenth round of 3-BP. (There was then no evidence of cancer found).

Sure, nebulized 3-BP makes quite a bit of sense. Avoiding systemic toxicity using that dosing route is a good idea. It is difficult to understand why this approach has not resulted in a published human article.

I would just be careful about being too creative.We  are starting to get a feel for the dose range for straight 3-BP. Combine cautiously.

If you can give the tumor a clear hit with an aersol that could be a powerful treatment. The metastatic melanoma patient given IV 3-BP with paracetamol also had a large lung tumor. {This tumor was the actual cause of death (hypoxia).} With 3-BP, it is such a powerful anti-cancer drug that the main concern is not so much the cancer but the TLS and other side-effects. The paracetamol massively amped up the response to 3-BP. This patient's last labs did not report any cancer left (LDH of about 10) and probably would have soon developed TLS.

I would ask the thought leaders on the thread for a comment on the tumor burden required for possible TLS. As a guess an 8 cm tumor with rapid destruction could do it.

I am glad you're now aware of the TLS risk. It would be best to bring on board a medical team that could help out with TLS etc. . The government's policy of making this underground is shameful. With proper medical oversight, the risk of 3-BP treatment should be manage

Another piece of general advice is not to delay excessively. You can always start small and work up until you see tumor response. This would be the safest approach. The doctors in the metastatic melanoma article treated with straight 3-BP for a month with minimal results and then gave 2 combination doses and the tumor was destroyed.

Published studies would have answered all these questions about dose, route etc. for you. The Columbia lung cancer patient appears to have been helped, though it is not clear exactly how the patient was treated.

able.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Sat Mar 28, 2015 05:41 PM
Quote | Reply@Jcancom

I thought the liver patient died from pneumonia, and not from 3BP treatment.  Dr Ko is reported as saying she only wished they had kept him in a plastic bubble i.e. isolation until he was much stronger.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Mar 28, 2015 06:02 PM
Quote | ReplyArticle said liver failure.

I do not understand why they were so fixated on destroying every last cancer cell, when the patient had such a huge burden of cancer cells that he was processing. The liver was regenerating. From what was reported, tapering back the 3-BP in  September would have been a good idea.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Sat Mar 28, 2015 08:38 PM
Quote | ReplyI read Travis Christoffersen's account again and be says Yvar died from pneumonia with his liver unable to cope with the antibiotics used. A real unfortunate outcome.

The description of what happened after the second dose is not consistent with a TLS http://emedicine.medscape.com/article/282171-overview  but hepatic encephalopathy. They only made the diagnosis after being asked to check ammonia levels. But TLS you would really see disturbance of urea, calcium, potassium, and uric acid. And coma is not a feature. So, this is very reassuring.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by adickens7 on Sat Mar 28, 2015 09:22 PM

Quote | Reply

On Mar 28, 2015 8:22 PM james-peters wrote:

Although dietary energy restriction and anti-glycolytic cancer drugs will have therapeutic efficacy against many tumors that depend largely on glycolysis and glucose for growth, these therapeutic approaches could be less effective against those tumor cells that depend more heavily on glutamine than on glucose for energy. Glutamine is a major energy metabolite for many tumor cells and especially for cells of hematopoietic or myeloid lineage. Glutamine metabolism can be targeted in humans using the glutamine binding drug, phenylacetate, phenylbutyrate or the glutamine analogue DON (6-Diazo-5-oxo-L-norleucine). Toxicity, however, can be an issue in attempts to target glutamine metabolism using DON. Recent studies suggest that the green tea polyphenol (EGCG) could target glutamine metabolism by inhibiting glutamate dehydrogenase activity under low glucose conditions. Phenylbutyrate is metabolized to phenylacetate and binds to glutamine and this is eliminated via the urine so could be used. That said other amino acids could be used, so a low to moderate protein intake would help also on this diet. The dosage for 2DG is 30-40mg/Kg and phenylbutyrate is 3-5g/day. Other drugs like DCA, 3BrPA should also be used (most of us know this). There are also many other drugs/supplements that could be helpful too. Omega 3 fatty acids can reduce the cachexia phenotype and help with maintaining low glucose levels and elevate ketone levels. With 3BrPA it knocks out both sources of ATP, so you may not need a glutamine binding drug
Great post.

In addition, phenylbutyrate is a histone deacetylase inhibitor (HDACI). Cancer wants to crank the cell DNA tighter and tighter and phenylbutyrate inhibites this.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586072/           The following multiple activities have been assigned to the ability of phenylbutyrate to protect normal tissues: (i) the activity of an HDACI;[38] (ii) the activity of a chemical chaperone;[39–41] and (iii) the activity of an ammonia sink.[42,43] HDACIs, such as phenylbutyrate, have shown a wide range of abilities: (i) they are able to cause cell cycle arrest in the G1 and/or G2 phase; (ii) they induce differentiation and/or apoptosis in a variety of cell types;[44] (iii) they induce the transcriptional activation of certain genes, such as the one for cyclin-dependent kinase inhibitor p21, which has been related to tumor suppression growth and prevention of cell cycle progression;[45,46] (iv) they inhibit tumor growth in animal models with little toxicity in non-tumor cells;[47] and (v) they enhance the expression of a wide variety of transiently transfected transgenes in tumors, both in vitro and in vivo, through their effect on the acetylation of histones.[46,48] The combination of p53 gene therapy with an HDACI, for example, FR901228 (romedipsin/depsipeptide) or phenylbutyrate, has shown enhanced therapeutic efficacy in vitro[46] and in vivo.[49]
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Mar 28, 2015 09:33 PM
Quote | ReplyNot completely sure, though this seems to describe the problem.

After the second round:

"The diagnosis was hepatic coma, which usually results in
death. It was suspected that the patient was undergoing a
potential tumor lysis syndrome (TLS) after three 3BP treatments."

They suspected that this form of liver cancer presents TLS in an atypical way.

"Therefore, it is suggested that the rise in blood ammonia
following 3BP treatment was due to FLC cell death, releasing
considerable amounts of cellular proteins. This elevation
of blood ammonia may be characteristic of TLS of FLC as
TLS is generally diagnosed by acute elevations of uric acid,
potassium, and phosphorus in other cancers."

The overwhelming burden of destroyed tumor cells was too much to manage.

"In December 2009 the edema and ascites were becoming more problematic. Liver functions were overloaded due to rapid destruction of the tumor cells resulting in the liver’s inefficient detoxification. Despite regeneration of the healthy liver cells, this process apparently could not compensate adequately for the rapid destruction of tumor cells and could not detoxify the dead cancer cell debris fast enough. Consequently, the blood albumin levels were decreasing. The patient passed away 2 years after his first diagnosis due to an overload of liver function."
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Sat Mar 28, 2015 10:00 PM
Quote | ReplyYes, so it doesn't really sound it is going to be a problem except in those with marginal liver function.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Mar 29, 2015 07:49 AM
Quote | ReplyIt is important to be aware that even with a team of medical experts the liver patient developed a nearly fatal TLS response after the third dose of 3-BP. The patient with metastatic melanoma also  had an unpredictedly extreme anti-cancer to the therapy.

Letting doctors to help you manage 3-BP treatment seems sensible.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Sun Mar 29, 2015 12:27 PM
Quote | ReplyThe melanoma patient also died from pneumonia.His  left lung was destroyed but his right lung was not. Rumour markers improved but no reduction in tumour size reported.

And so both cases died from pneumonia, but white cells not affected.

As for getting medical help for a drug unlicensed here, that is going to be next to impossible.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Mar 29, 2015 12:34 PM
Quote | ReplyDear Zhaosr,

I am in a similar situation as you are. TLS is something to be aware of when considering 3BP indeed. However, in the end TLS indiactes effectivness - it is what we want in the end, i.e an effective element. But we need to control it. That is the key. Not doing anything clearly will not help.

My wife (and some other people I know) started 3BP IV and is still taking that with no side effects - the protocol is in line with the treatment in Egypt but without Paracetamol. So far at a relatively low frequency - we intend to increase that soon. Nebulizing is a great way to deliver directly to the lungs but when the patient has important lung tummors the delivery by nebulizer has to be done with a lot of attention, I think. My wife nebulized once 5mg only and she felt a bit of activity in the lungs. In case you decide to have 3BP nebulized, I would realy start with very low dose and also suggest to have some lipophilic glutathione next to you. Nebulazing gluthadione would stop the activity of 3BP. I bought this one from here www.liposomalglutathione.com.

For patints such as Howard with no lesions in the lungs, higher doses seem to be suitable.

Next, it would be helfull if you can order Helleborus niger. This is a new German product, on the line of Mistletoe, produced by one of the larged Mistletoe producer in Germany (so the quality is no question) prepared as an injection but it can also be nebulized. Here is a link about it in German but Google will translate it: http://www.helixor.de/komplementaere-medizin/helleborus-ther

You can order this one at online german pharmacies (I hope also from US). It is relatively cheep. It has anti-tumor and immunomodulatory effects and anti-inflammatory properties. It is also specifically indicated for lung tumors.

What I like about this one is that it has also cardiac glycosides inside, which are powerfull anti-cancer elements that interfeer with Na/K exchange, similar to powerfull anti-cancer elements such as Oleandrin, Bufalin, Ouabain.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Mar 29, 2015 12:38 PM

Quote | Reply

On Mar 29, 2015 4:27 PM zhaosr wrote:

The melanoma patient also died from pneumonia.His "" target="\_blank" rel="nofollow">http://pneumonia.His " target="\_blank" rel="nofollow">pneumonia.His  left lung was destroyed but his right lung was not. Rumour markers improved but no reduction in tumour size reported.

And so both cases died from pneumonia, but white cells not affected.

As for getting medical help for a drug unlicensed here, that is going to be next to impossible.
This is a very good point. I am puzzeled about this too. Why both died from pneumonia?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Sun Mar 29, 2015 12:55 PM
Quote | ReplyDear Danielus,

Are you able to share the  proprietary formula for the 3-BP i.v. formula that your wife is using?  If not, could you provide a link for the protocol for the Egypt treatment that may better describe it for me?

I have Stage IV breast cancer--mets to the spine and clavicular/axillary lymph nodes.  Unable to travel because of family responsibilities and finances, but I am working with a holistic doctor and doing Vit.C i.v.'s, DMSO, etc.  But I need to address this serious condition with "bigger guns".  This is a very critical year for me regarding my future.

I would appreciate any help you can provide about using the 3-BP i.v.

Many thanks...
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Mar 29, 2015 01:37 PM
Quote | ReplyDear Jetsparkle,

I am sorry to hear that. Fortunately, I think, we here are on the right track and combining e.g. ketogenic diet, 3BP, etc we get to the highest chance of success on this planet.

While in the German case a proprietary formula has been used indeed, in Egypt case they used 3BP unformulated. This is what we use as well.

The administration protocol we use is relatively simple:

- for IV the best is to obtain 3BP from a reliable supplier such as Sigma Aldrich, Santa Cruz etc.

- mix 3BP with water for injection in a sterile can - e.g. for a person of 50kg who may want to start with 0.5mg/kg to test the reaction to 3BP, the quantity to start with would be 25mg. This can be mixed in a few ml water for injection.

- use sterile filters for syringe of 0.2um to sterilize the solution while pushing thsi sollution into 500ml saline

- once the 3BP is in saline you want to startdelivery imidiatly since its stability is limitted

- the deliveery should take place in a dark room to keep 3BP as much as possible stable - alternatively, make sure the IV kit has a dark color to reduce the 3BP solution exposure to light

- you want to have 3BP administrated as soon as possible but depending on the dose there may be some burning sensations - in general that starts at about 1.5mg/kg in 500ml saline

- if the burning sensation is too high and the patient needs long time for the administration I would firs only mix half the 3BP dose in 250ml saline and once that is finished I would mix the other half and aadministrate - this is done in order to keep 3BP as high as possible

- like Andrew said, to open up MCTs the matient may also take some Oxygen during the administration

- starvation will also upregulate MCTs - so try not to eat before the IV

- also to open up MCTs, sodium butyrate may be administrated during the 3BP traetment (taken even in the days when there is no administartion)

- eliminate anti-oxidants as much as possible at least during the 3BP adminstration day

- after 3BP administration at about one hour Artemisinin or Vitamin C can also be delivered. I do not know what DMSO would do but at 5ml IV seems to be no issue

- I think 1.5mg/kg is the dose when effectivness may start to become visible at a frequency of 3x/week - this seems to be around the effectivness treshold but it depends on people/supplements/etc. - this is a personal oppinion + visible in the Egypt case treatment

This is on short what we do. If you have questions let me know.

All the best!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Mar 29, 2015 01:45 PM
Quote | ReplyIf I would chose for chemo or radiation, before that I would make sure I take some Terandrine. This can be bough from china as powder or even better in pharmacies there they have capsules and IV solution. Ask a Chinese friend (or supplier on Alibaba) to buy it for you. It will help reduce MDR and has been shown to seriously increase effectivness of chemo and radiation.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Sun Mar 29, 2015 01:49 PM
Quote | ReplyDear Danielus,

My heartfelt thanks to you for providing this important information!  I will share it with my holistic doctor--and, if any questions he needs answered, will contact you again.

Very best to you and your wife--and to all the others on this forum who are sharing their knowledge and  willingly helping others.  I truly feel the methods mentioned here are the very best way to address our health concerns and to have hope for our futures.

Thank you again for your kindness--very, very much appreciated.
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# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Mar 29, 2015 01:50 PM
Quote | ReplyIf I would chose for chemo or radiation, I would make sure I would add Whole Body Hyperthermia (WBH) and Local Hyperthermia treatments. In Bochum, Germany there is a private clinic that has great results combining these. For example, WBH at one day after chemo strongly increases the anti-cancer effectivness of chemo.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Sun Mar 29, 2015 02:20 PM
Quote | ReplyDanielus,

I have had IPT in Mexico --also have had two areas in spine radiated in U.S.  Some hyperthermia in Mexico--but not well tolerated.  But immunology is the way to go right now since tumor markers  are rising and out of range.  And surgery for the new tumors is out of the question--the doctors think I am too fragile for it--plus I do not want to go that route again (too much infammation, etc.)    I did have a lumpectomy 3 years ago--and the cancer spread quite vigorously afterwards.  So much for typical conventional medicine for me!  Cryoablation might be something for the future--but the costs are extremely high.  And I think I would rather attempt the 3-BP route and address my situation that way--along with other therapies.

Always appreciate any updates here on the forum.  Everyone has only the best interests of others at heart.  Learning curve, yes--but a better direction in which to go.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Sun Mar 29, 2015 02:48 PM
Quote | Reply@Danielus

Very useful, thank you.

How are you and the people you know monitoring response?  Tumor markers, x-rays?

If we can get enough people, and data, we can get an informal case series together.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Mar 29, 2015 02:50 PM
Quote | ReplyOne simple option that led to good results is the combination of ALA and HCA. This is easy accessible treatment combination. Read this paper and you can directly apply that: http://www.hindawi.com/journals/cpis/2013/827686/

To my knowledge the effect may not be long term and it may not work after a year or so but when it works it gives additional time to find THE solution.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Mar 29, 2015 02:56 PM

Quote | Reply

On Mar 29, 2015 6:48 PM zhaosr wrote:

@Danielus

Very useful, thank you.

How are you and the people you know monitoring response?  Tumor markers, x-rays?

If we can get enough people, and data, we can get an informal case series together.
Just started not long time ago (also step by step with the dose and frequency) - so is difficult to conclude anything. There is somebody who already sees markers going down. As soon as there is something relevant will let you know. So far it seems to be difficult to deliver through normal IV in the arm and a port may need to be instaled for an easier delivery of the solution.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Sun Mar 29, 2015 03:02 PM
Quote | ReplyDid you also buffer the solution prior to giving it to your wife via nebulizer?

And when you say difficult to give IV, it is because it is highly irritating to veins?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by skaran on Sun Mar 29, 2015 03:07 PM

Quote | Reply

On Mar 29, 2015 4:38 PM Danielus wrote:

On Mar 29, 2015 4:27 PM zhaosr wrote:

The melanoma patient also died from pneumonia.His " target="\_blank" rel="nofollow">pneumonia.His  " target="\_blank" rel="nofollow">pneumonia.His " target="\_blank" rel="nofollow">pneumonia.His  "" target="\_blank" rel="nofollow">http://pneumonia.His " target="\_blank" rel="nofollow">pneumonia.His  " target="\_blank" rel="nofollow">pneumonia.His " target="\_blank" rel="nofollow">pneumonia.His  " " target="\_blank" rel="nofollow">pneumonia.His " target="\_blank" rel="nofollow">pneumonia.His  " target="\_blank" rel="nofollow">pneumonia.His " target="\_blank" rel="nofollow">pneumonia.His  "" target="\_blank" rel="nofollow">http://pneumonia.His " target="\_blank" rel="nofollow">pneumonia.His  " target="\_blank" rel="nofollow">pneumonia.His " target="\_blank" rel="nofollow">pneumonia.His  " " target="\_blank" rel="nofollow">pneumonia.His " target="\_blank" rel="nofollow">pneumonia.His  " target="\_blank" rel="nofollow">pneumonia.His " target="\_blank" rel="nofollow">pneumonia.His  "" 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Rumour markers improved but no reduction in tumour size reported.

And so both cases died from pneumonia, but white cells not affected.

As for getting medical help for a drug unlicensed here, that is going to be next to impossible.
This is a very good point. I am puzzeled about this too. Why both died from pneumonia?
If your immune system is weakened (by chemo radiation etc), it may be very difficult to fight off colds, flu, or other viral infections. Antibiotics are metablized by they liver.  Liver cell necrosis contributes to impaired drug handling in liver failure. Drug-induced liver injury has been reported almost in 50% of the drugs in the physicians’ desk reference. More than 100 drugs are incriminated in causing fulminant hepatic failure.

Hope this clears up that the probabilites are that the damage was done was by the treatment for pneumonia and not by 3BP.

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Mar 29, 2015 03:15 PM
Quote | ReplyYes, Zhaosr, I did incresed the pH to about 7 using Sodium Bic. I did mixed with 4ml distilled water and 8 drops DMSO.

Difficult to me it means possible but with some pain (a bit in the same way as Vit C) - and that is at about 1.5mg/kg in 500ml saline. So going to higher dose I expect more pain and thsis is why I would better go for a port instead.

If anyone goes on thsi route I would make sure I have next to me most of the anti TLS drugs we listed on this discussion sometime ago.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Mar 29, 2015 03:25 PM
Quote | ReplyThat is an interesting point of view Skaran! So you need to protect the patient as much as possible against possible infections and keep the immune system continuosly awake. In that case, would you ask the patient to come for treatments at the hospital or keep him at home?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Sun Mar 29, 2015 03:42 PM
Quote | ReplyPity we don't have the specifics.  I might ask my wife to have a pneumococcal vaaccine anyway.
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# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Mar 29, 2015 03:47 PM

Quote | Reply

On Mar 29, 2015 7:42 PM zhaosr wrote:

Pity we don't have the specifics.  I might ask my wife to have a pneumococcal vaaccine anyway.
What specifics you are reffering too?

Great idea regarding pneumococcal vaccine!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Sun Mar 29, 2015 04:32 PM
Quote | ReplyThe type of infection that occurred.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Mar 29, 2015 06:04 PM
Quote | ReplyGreat posting everyone! Real breakthrough day for the thread. Yeah, step back and let the knowledge leaders post.

Now that we have got the recipe down and other important matters, I wanted to try this idea out.

In a recent 3-BP patent   http://www.google.com/patents/WO2008076964A1?cl=en    radioactive 3-BP was made starting with pyruvic acid and Br2 was added to displace a methyl group (see the patent diagram near the bottom). The patent assumed that this was so obvious to anyone with even a basic knowledge of chemistry that no details were provided.

This is of interest as pyruvic acid is readily available online for exceptionally reasonable prices and bromine also appears to be widely used. Pyruvic acid could be converted into 3-BP by the simple substitution noted above. Did anyone pay attention during high school chemistry when they talked about these reactions? Would it be as easy as suggested in the patent to make 3-BP? Perhaps just gasify the bromine and bubble it into the pyruvic acid?

One advantage in doing so would be that one would know exactly what chemicals were used and what the possible products could be. If one bought online fungicide 3-BP, one woudl have no idea what the possible contaminats might be. By doing the synthesis oneself one would know the identity and safety of all the products.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Sun Mar 29, 2015 06:49 PM
Quote | ReplyGood stuff on ALA and HCA.

Shall see where I can find this in the local health shops.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Mar 29, 2015 08:18 PM
Quote | ReplyMight to be handy to have a lactate monitor.

http://crossbikereview.com/gear/reviews/lactate-plus-analyze
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Sun Mar 29, 2015 10:51 PM
Quote | Reply\*

* Poliovirus Trial - Duke Cancer Institute - Duke Universitywww.**cancer**.duke.edu/.../index.php?...\*\*

Duke Comprehensive Cancer Center

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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Mon Mar 30, 2015 01:39 AM
Quote | ReplyInstead of a dark room, or dark tubing, one can just wrap the bag and iv giving set in tin foil when the drug is light sensitive.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Mon Mar 30, 2015 03:54 PM
Quote | ReplyAnother paper on HCA and ALA http://www.ncbi.nlm.nih.gov/pubmed/24511042  from last year
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Mon Mar 30, 2015 04:16 PM
Quote | ReplyYes, this one includes LDN as well. They did had another paper where they were also including Chloroquine and possibly Metformin. Anyway, this is a nice combination to be aware of.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Tue Mar 31, 2015 03:31 PM

Quote | Reply

On Mar 30, 2015 12:18 AM Jcancom wrote:

Might to be handy to have a lactate monitor.

http://crossbikereview.com/gear/reviews/lactate-plus-analyze r"" target="\_blank" rel="nofollow">http://crossbikereview.com/gear/reviews/lactate-plus-analyze  target="\_blank" rel="nofollow">http://crossbikereview.com/gear/reviews/lactate-plus-analyze
Should i have my dr get a lactate monitor? 2 of my doctors are putting together a DCA protocol with inf from various doctors who are doing it and looking at research I found and some they found. (So Cal) I am starting on Metformin now to see what the best dose is and doing that from coconut to suplement ketones later when I do the KETO diet. One of the docs at a med school recommends Vit C after the DCA IV and gluthione after the other iV (2x a week) I am refusing the glut because I have read that cancer needs it and you have to deplete it to kill cancer. Have to up B vits as Metformin depletes them. The 2 docs are sharing me ie 1 IV at 1 dr and the other at the other dr. They are comparing notes etc. My onc knows what we are doing as well. I am getting them to look ate the MitoQ and alpha-lipoic acid and hydroxycitrate.to  see if there is value in adding that based on research. Any suggestions appreciated starting in about 3 weeks. They are very into partnering with patients and in fact this was my idea as they had no previous exp with DCA.

# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Tue Mar 31, 2015 05:50 PM
Quote | ReplyI wonder if we should be moving these discussions to a dedicated board. This thread is very long now at 48 pages, and I find I have to keep re-reading to find posts.

I have a xenforo board that I could add a section for metabolic diy treatments for cancer.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Tue Mar 31, 2015 06:23 PM
Quote | ReplyYeah, I agree that the supply lines are getting a little stretched. Yet, on other forums when new management tries to shake up the rules often the crew on a thread give up in frustration as they try to figure out the new way.

It's sort of like with 3-BP: we shouldn't let success become the problem. One thing that you could do to help organize the information is copy and paste the thread into a text document. You could then organize/index/recompile the information however you liked. The software for most of these threads is bad. Perhaps xenforo has worked it through. Even having collapsable topics within the thread would help quite a bit. Hyperlinking words to other parts of the thread would also be useful. As it is, this thread is not much more organized than a typical teenager's bedroom.

I was thinking that perhaps we should soon set up a parallel party thread for our upcoming 500th post. Our fans from all over the world could post their best wishes. I am hoping for a few "You Rock Jcancom"s etc.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Tue Mar 31, 2015 06:38 PM
Quote | ReplyI am so glad the lactate monitor idea was picked up on. I was thinking especially about it being used to monitor for TLS. Having ready access to constantly measure lactate levels would be very helpful, in particular when treating with 3-BP. It might be unwise to depend on outside labs etc. if these lactate monitors are as accurate and inexpensive as they are claimed to be.

It is difficult for me to understand why cancer patient's have not been more compulsive about measuring their lactate levels with these simple monitors. Many people are interested in constantly measuring their investment performance, while cancer patients will often have only a vague idea of what their LDH level is. Cancer patients could create their own "chart" which measured how much of a cancer burden they had. The compensation of their doctors could be related to what they did to decrease the LDH level. Having a clear quantitative measure of success has played a substantial role in the financial world, it would likely do the same in the medical world.

Lactate levels in resting healthy people should be close to zero. I have often wondered whether the cancer epidemic might simply stop if people were more aware of their LDH levels. Even people who refuse to visit their doctors might be willing to submit to an occasional thumb prick.

Members of the thread could look around for these lactate monitors and make sure they are in fact lactate monitors. Some of the lactate monitors were not actually measuring lactate but some other measure that related to lactate.

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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Tue Mar 31, 2015 06:58 PM
Quote | ReplyThe most important things to monitor in TLS are potassium (hyperkalemia, which leads to fatal arrhythmia), and calcium (tetany). I haven't been convinced by the data presented so far that TLS is an important feature of 3BP treatment.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Tue Mar 31, 2015 07:19 PM
Quote | ReplyLactate might be a better measure as it is upstream of the consequences of the destruction of the cancer cell (i.e.  potassium, calcium etc.). With lactate you are measuring the body burden of metabolically active cancer. When lactate falls, it means that the cancer cells have been destroyed or highly stressed. If the cancer cells are truly destroyed, then at some point potassium,calcium etc. levels will increase. When measuring lactate, it would seem that you are getting advanced warning of these downstream events.

LDH was one of the main measures used to gauge treatment success. In fact, the doctors made a big point of noting that the patient had been metabolically cured of cancer as measured by the LDH. The large inactive tumor mass that remained did not relate to the tumor's actual viability.

Could others on the thread comment on the idea that LDH might be useful as an upstream measure of cancer destruction along with downstream measures?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Tue Mar 31, 2015 07:57 PM
Quote | ReplyI think this is unlikely to be true as it implies the cancer patient is in a state of metabolic acidosis all the time. We also know that some cancer cells are able to take up lactate being produced by neighbouring cells (via aerobic glycolysis), so there may not be any measurable lactate.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Tue Mar 31, 2015 08:04 PM
Quote | ReplyI'm spending about 6-8 hours each day at the hospital with my wife (attempted pleurodesis just now) so have lots of spare time. I might try and summarise some of the points.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Tue Mar 31, 2015 08:24 PM
Quote | ReplyJcancom,

Agree totally with that first paragraph you wrote.  Would like to encourage continuing using this message board--some of us here (like I am!)  are not that computer literate and will be floundering around if things are drastically changed.  And we truly need your expertise when it comes to anything new about 3-BP--and any updates you can provide.

I would be at a true loss if things became too different.  I like your phrase "we shouldn't let success become the problem".  And your other following suggestions (most of them Greek to me!) could still be initiated--and still the thread would be easily read and available for those of us still in the dinosaur age!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Tue Mar 31, 2015 09:11 PM
Quote | ReplyThank you for your kind words.

I have seen with my own eyes what can happen on threads like these when there is even a slight change in the setup. It is surprising and quite disturbing to watch thread members who have been providing one another with support and advice to cope with serious (even life threatening) illnesses be unable to adjust to minimal software modifications.

This thread is one of the most active 3-BP sites on the web. This is the reason that so many of the heavy hitters are posting here. We need to protect it because many appear to be benefiting from these posts.

We should simply accept that threads can be one of life's great gifts, though fragile and sometimes ephemeral.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Wed Apr 01, 2015 02:12 AM
Quote | ReplyHow to prevent and manage Tumor lysis syndrome www.nursingcenter.com  › Home › Journal Articles › Journal Issue

# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Wed Apr 01, 2015 03:56 AM

Quote | Reply

On Mar 29, 2015 7:42 PM zhaosr wrote:

Pity we don't have the specifics.  I might ask my wife to have a pneumococcal vaaccine anyway.
Zhaosr, have you done the vaccine? Or did you checked with the hospital if they will give it to your wife? Do you expect any drawback as well?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Wed Apr 01, 2015 03:58 AM

Quote | Reply

On Mar 30, 2015 12:18 AM Jcancom wrote:

Might to be handy to have a lactate monitor.

http://crossbikereview.com/gear/reviews/lactate-plus-analyze r"" target="\_blank" rel="nofollow">http://crossbikereview.com/gear/reviews/lactate-plus-analyze  target="\_blank" rel="nofollow">http://crossbikereview.com/gear/reviews/lactate-plus-analyze
This is a very interesting idea indeed. Is this a reliable tool?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Wed Apr 01, 2015 04:44 AM
Quote | ReplyI mentioned this to her oncologist before she started her chemo and he dismissed the need for it.  But when I read this http://www.medscape.com/viewarticle/421487\_6,  it clearly states that influenza and pneumococcal vaccines should be given.

So, I'll wait until she is out of hospital, and arrange for it to be given then.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Wed Apr 01, 2015 04:46 AM
Quote | ReplyThe only theoretical disadvantage is that sometimes cancer patients who get pneumonia or influenza, can sometimes under a spontaneous remission due to the immune activation that occurs.  This is the basis of Coley's toxin, or mixed bacterial vaccination for the treatment of cancer.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Wed Apr 01, 2015 04:54 AM
Quote | ReplyHere is some more info on Coley's toxin http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312698/  http://www.mbvax.com/  http://www.pvanuden.com/2014/03/immunotherapy-to-cure-cancer
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Wed Apr 01, 2015 04:59 AM
Quote | ReplyYes, this is the dilema ... yet the risk is higher than chance for immune activation ... I am not yet sure what to do but I already have the vaccine at home.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Wed Apr 01, 2015 05:09 AM

Quote | Reply

On Apr 01, 2015 8:59 AM Danielus wrote:

Yes, this is the dilema ... yet the risk is higher than chance for immune activation ... I am not yet sure what to do but I already have the vaccine at home.
What kind of vaccine?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Wed Apr 01, 2015 05:10 AM
Quote | ReplyWell, the chance of spontaneous remission is remote, and serious poor outcome from infection high, so I'd go for the vaccines.

Which raises another point.  I see chloroquine being advocated here, but chloroquine dampens down the innate immune system ( that's why it is used in lupus), and Coley's toxin worked by activating the innate immune system.  Tricky stuff.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Wed Apr 01, 2015 05:12 AM

Quote | Reply

On Apr 01, 2015 9:10 AM zhaosr wrote:

Well, the chance of spontaneous remission is remote, and serious poor outcome from infection high, so I'd go for the vaccines.

Which raises another point.  I see chloroquine being advocated here, but chloroquine dampens down the innate immune system ( that's why it is used in lupus), and Coley's toxin worked by activating the innate immune system.  Tricky stuff.
Dr Coley used heat treated bacteria which caused a full blown immune responce, innate and then adaptive
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Wed Apr 01, 2015 05:29 AM
Quote | ReplyDo you have any reason to implicate the adaptive immune system in the remissions that were seen?

# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Wed Apr 01, 2015 05:35 AM
Quote | ReplyThis is something I read a few days ago http://clincancerres.aacrjournals.org/content/18/19/5449.lon

Unmethylated CpG, bacterial DNA, and other TLR agonists are likely to stimulate the innate immune system to initiate the production of a complex cascade of cytokines (20–22). These include IL-1β, TNF-α, and IL-6, which act as endogenous pyrogens that elevate the body temperature. TNF-α regulates the inflammatory response, induces apoptosis, and disrupts neovascularization of solid tumors. TNF-α also amplifies the innate immune response by inducing IL-12 production that provides a critical link between innate and adaptive immunity by driving type-1 responses through the induction of IFN-γ production by natural killer cells, type-1 helper cells, and cytotoxic T cells. IFN-γ plays potentially several important roles in the immune response to tumors including tumor immunosurveillance and direct antitumor activity. Thus, IL-6, TNF-α, IL-12, and IFN-γ, collectively represent cytokines that are critical at the various stages of the host response to bacterial products.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Wed Apr 01, 2015 11:23 AM
Quote | ReplyThe newsletter says there is no screening for ovarian cancer. Not exactly true- the ultrasound tech at a local hospital tells me they can find it if there is a baseline ultrasound. You just compare the size in that area. They have detected several ovarian cancers there after which a CA125 ot HE4 blood test can be done and a PET scan.

If any one on this thread has any suggestions on the DCA thing I am going to do please feel free.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by bella20 on Wed Apr 01, 2015 12:43 PM
Quote | ReplyHi Jet, Can I ask what clinic in Mexico you go. I have treatment in Mex too they uses 3- BP for me too

God Bless
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Apr 01, 2015 12:51 PM
Quote | ReplyVery interesting!

Could you share names of Mexican clinics using 3-BP?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Wed Apr 01, 2015 01:21 PM

Quote | Reply

On Apr 01, 2015 4:51 PM Jcancom wrote:

Very interesting!

Could you share names of Mexican clinics using 3-BP?
The Munoz Clinic in TJ told me a while back they do 3BP pills and want to do more 3BP but need to do more research.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Wed Apr 01, 2015 01:46 PM
Quote | Replybella20,

When I went to the Mexican clinic, I was not using 3-BP.  Not sure what they are doing now.

In what form do you  use the 3-BP--oral or i.v.?  Have you or others have success with using it--or would you contribute your current health status to other methods used?

I would be interested in learning what clinics in Mexico now offer 3-BP.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by bella20 on Wed Apr 01, 2015 03:49 PM
Quote | ReplyYes, I am at Dr Munoz's clinic now. This time he used 3-BP IV for me. Did you treated at his clinic too. Maybe I knew you then.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Wed Apr 01, 2015 03:54 PM

Quote | Reply

On Apr 01, 2015 7:49 PM bella20 wrote:

Yes, I am at Dr Munoz's clinic now. This time he used 3-BP IV for me. Did you treated at his clinic too. Maybe I knew you then.
Sometimes people want to remain anonymous on this site. I am interested to hear Munoz is now doing IV 3BP as they were not doing it when I called them. The AZ clinic does IV anal and oral 3BP I believe. What results does Munoz  have and what is the cost?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Apr 01, 2015 04:13 PM
Quote | ReplyReally, you were treated with no IV 3-BP? (Not an April Fool's joke?)

Could you give us a review of your cancer burden/type, treatments give, exposoure to 3-BP, response markers to 3-BP (e.g. LDH), any side effects (?), etc. . ?

A great many on this thread would be greatly appreciative if you might share this inforamtion.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by bella20 on Wed Apr 01, 2015 04:20 PM
Quote | ReplyI din't know yet. They didn't bill me yet. When I have I will let you know. On the 1st and 2nd trip He didn't use it . This is my 3rd trip to check up and He has on IV for any patient now even me.

### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Wed Apr 01, 2015 04:24 PM
Quote | ReplyMaybe you coould ask the doctor to tell us what he does?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Wed Apr 01, 2015 04:29 PM

Quote | Reply

On Apr 01, 2015 8:20 PM bella20 wrote:

I din't know yet. They didn't bill me yet. When I have I will let you know. On the 1st and 2nd trip He didn't use it . This is my 3rd trip to check up and He has on IV for any patient now even me.
Hi Bella, did you feel anything during the 3BP treatment or after that? How was it?

Was there anything special compared to other IVs you had before?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by bella20 on Wed Apr 01, 2015 06:04 PM
Quote | ReplyDanielus,

Honestly, I don't feel any different. They give IV like other IV. I will see when the test results come out this week. My last 2 treatment was good all scan are clear. onlything My CEA is going up little  this thime thay why he use 3 \_BP, B17 and Nuerolax this time to bring DEA down to normal. Will see. I beleive Will
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### RE: Anyone used 3bp (3-bromopyruvate)?

by bella20 on Wed Apr 01, 2015 06:07 PM
Quote | ReplyI mean CEA not DEA   sorry for my typing mistake
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Wed Apr 01, 2015 06:11 PM

Quote | Reply

On Apr 01, 2015 10:04 PM bella20 wrote:

Danielus,

Honestly, I don't feel any different. They give IV like other IV. I will see when the test results come out this week. My last 2 treatment was good all scan are clear. onlything My CEA is going up little  this thime thay why he use 3 \_BP, B17 and Nuerolax this time to bring DEA down to normal. Will see. I beleive Will
Thanks for your response Bella. It will be interesting to know if the 3BP they use there is from Dr. Ko or is just unformulated 3BP? But probably this would be difficult to know.

Another interesting point is to know what is the dose they are giving to you.

Maybe you can ask your doctor if is a good idea to get Metformin as well?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Wed Apr 01, 2015 06:50 PM
Quote | ReplyBella20

You have stage 4 colon cancer with liver involvement? Were you cancer free, and it has come back? Or is this treatment to prevent recurrence?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by bella20 on Wed Apr 01, 2015 07:09 PM
Quote | Replyyes, colon cancer met to liver and abdoment. After 4 months treatment at Dr. Munoz ( San Diego Clinic) all scans came out clear, But CEA still not in normal range, Now CEA is going  up but still don't see on Pet scan or MRI . That why he has to use another weapon to bring the CEA to normal.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by bella20 on Wed Apr 01, 2015 07:15 PM
Quote | ReplyI don't know he use 3BP from Dr. Ko I din't know Who is Dr. Ko????? . What is the Metformin? let me ask him tomorrow What is that for ???

I believe he will know He is really smart Doctor. I really trust on him a lot .

He gives me IV 3-BP here and he will give pill to take home
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Apr 01, 2015 07:32 PM
Quote | ReplyJust to alert readers of this thread that I have started a new thread "Anyone used 3BP?- Parallel Thread".

The intention is to try and help manage our success.

"We shouldn't let success become a problem."

Posts that might be somewhat off-topic or other fan comments could be posted to the parallel thread. This other thread could also be used to celebrate our recent 500th post.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Wed Apr 01, 2015 08:46 PM
Quote | ReplyDr Ko is the person who discovered the anti cancer effect of 3BP and was working on more effective formulations.

Metformin is a drug for diabetes that has some anticancer activity as well.

# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Wed Apr 01, 2015 09:36 PM

Quote | Reply

On Apr 01, 2015 11:09 PM bella20 wrote:

yes, colon cancer met to liver and abdoment. After 4 months treatment at Dr. Munoz ( San Diego Clinic) all scans came out clear, But CEA still not in normal range, Now CEA is going  up but still don't see on Pet scan or MRI . That why he has to use another weapon to bring the CEA to normal.
That is really fast to get a clear scan in 4 months! What was the treatment for that? Do you live near the clinic?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by bella20 on Thu Apr 02, 2015 12:01 AM
Quote | Replyok let me ask him tomorrow
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### RE: Anyone used 3bp (3-bromopyruvate)?

by bella20 on Thu Apr 02, 2015 12:06 AM
Quote | ReplyYes, it is fast While In USA I spend for 2 years for conventional and didn't help at all and getting worse. I live in USA , But I am at clinic now. They use IPT and some Alternative treatments. Dr. Munoz said if I didn't go thru conventional treatment. He will get rid of it sooner and the % cured higher. I knew some patients the same my situation they have cancer free more than 2 years on the roll
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Thu Apr 02, 2015 05:20 AM

Quote | Reply

On Apr 02, 2015 4:06 AM bella20 wrote:

Yes, it is fast While In USA I spend for 2 years for conventional and didn't help at all and getting worse. I live in USA , But I am at clinic now. They use IPT and some Alternative treatments. Dr. Munoz said if I didn't go thru conventional treatment. He will get rid of it sooner and the % cured higher. I knew some patients the same my situation they have cancer free more than 2 years on the roll
That is very impressive. You are like a walking ad for the clinic. I suppose a lot of people on this site would like to be cured as quickly as you. How could we find out what the treatment is and how much it costs?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Apr 02, 2015 11:17 AM
Quote | ReplyThe lactate monitor seems like a good idea. As a patient, it would be very useful to have such a measure to gauge treatment success.

Have any of the other thread members been able to confirm that lactate monitors actually directly monitor lactate levels? (It seems that some of these monitors measure lactate indirectly.)

The url I posted claimed that their lactate monitor was as accurate as a lab.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Thu Apr 02, 2015 11:22 AM
Quote | ReplyOh I sent the link to my doctor so i thought you were recommending it. I will ask her about it and let you know. I was not sure if I needed it for DCA IVS.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Thu Apr 02, 2015 11:42 AM

Quote | Reply

On Apr 02, 2015 3:17 PM Jcancom wrote:

The lactate monitor seems like a good idea. As a patient, it would be very useful to have such a measure to gauge treatment success.

Have any of the other thread members been able to confirm that lactate monitors actually directly monitor lactate levels? (It seems that some of these monitors measure lactate indirectly.)

The url I posted claimed that their lactate monitor was as accurate as a lab.
I should be clear about something. My doctors partner with me. Just because I sent the link to a doctor does not mean I will do what that doc says. I take all opinions into account and value those on this site as well as the information here. I would like to know if you all think a lactate monitor would be good to have for the DCA protocol I will be doing.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Apr 02, 2015 11:59 AM
Quote | ReplyI think my idea is amazing.

Think of all the cancer patients who spend 10s of thousands of dollars and are never very clear if it is actually helping them. Would they reward a financial advisor whithout looking at performance? Why are they not being as strict with their medical advisors?

A lactate monitor will tell you how much metabollically active cancer there is. Expensive scans (CT, MRI) will tell you where the cancer is.

My initial checks find that these lactate monitors monitor lactate and are accurate.

http://lactateplus.com/home.php

Anyone else want to comment?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Thu Apr 02, 2015 12:29 PM
Quote | ReplyI think your idea has great possibilities!  I will need to spend more time reading about as I am fairly in the dark about this.

I just googled lactate monitors and read on the www.vetlab.com  site that another monitor (Lactate Pro 2) is available.  The former one (Lactate Pro) is not longer being manufactured.  However, the new Lactate Pro 2, when being manufactured, did not have the medical market in mind--opting to focus on the sports training segment of the population.  This new monitor is proving unsuitable for medical monitoring and is not recommended for such.

I am glad you provided the link to the Lactate Plus monitor--have you done some in-depth research as to its capabilities?  I know you will understand better than I about this particular monitor and its usage for medical purposes.  I will defer to you on this one!

Always appreciate your input!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Thu Apr 02, 2015 12:38 PM

Quote | Reply

On Apr 02, 2015 3:59 PM Jcancom wrote:

I think my idea is amazing.

Think of all the cancer patients who spend 10s of thousands of dollars and are never very clear if it is actually helping them. Would they reward a financial advisor whithout looking at performance? Why are they not being as strict with their medical advisors?

A lactate monitor will tell you how much metabollically active cancer there is. Expensive scans (CT, MRI) will tell you where the cancer is.

My initial checks find that these lactate monitors monitor lactate and are accurate.

http://lactateplus.com/home.php "" target="\_blank" rel="nofollow">http://lactateplus.com/home.php " target="\_blank" rel="nofollow">http://lactateplus.com/home.php

Anyone else want to comment?
So in other words it tells you how much cancer there is. I thought it was to determine the TLS if you do 3BP or DCA. Can you clear this up for me?

# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Apr 02, 2015 01:39 PM
Quote | ReplyThe original posting was in the context of TLS. It was suggested at that time that measuring lactate might be one way to monitor treatment response to 3-BP with a heavy tumor burden. Perhaps this wuold give an upstream measure of treatment response. For example, with the metastatic melanoma patient LDH appeared to be a key biomarker of treatment response.

Measuring lactate could also be used more broadly by cancer patients to assess treatment response. Often people might just use a simple measure of tumor size as a guide for treatment response. The authors of the article on metastatic melanoma noted that tumor size did not relate to the amount of metabolically active cancer after 3-BP treatment. Even though the patient had a massive tumor burden after 3-BP treatment, it was almost entirely inactive.

The Nova Biomedical site makes clear claims about the accuracy and convenience of their lactate monitors.

http://www.novabiomedical.com/products/lactate-plus/

We might contact them or post to a high performance athlete forum about these monitors.

I defer to those on these site of greater wisdom than I about these monitors. Any comments?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Thu Apr 02, 2015 04:38 PM
Quote | ReplyAlthough this old paper http://www.ncbi.nlm.nih.gov/pubmed/498115  Lactate metabolism in patients with metastatic colorectal cancer. Cancer Res. 1979;39(12):4900–4904 "lactate levels in plasma and venous blood were elevated in patients with metastatic cancer", it also says that there was a poor correlation between lactate levels and tumor burden.  Whether one can use it as a personal tumor marker, who knows?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Thu Apr 02, 2015 04:50 PM

Quote | Reply

On Apr 02, 2015 5:39 PM Jcancom wrote:

The original posting was in the context of TLS. It was suggested at that time that measuring lactate might be one way to monitor treatment response to 3-BP with a heavy tumor burden. Perhaps this wuold give an upstream measure of treatment response. For example, with the metastatic melanoma patient LDH appeared to be a key biomarker of treatment response.

Measuring lactate could also be used more broadly by cancer patients to assess treatment response. Often people might just use a simple measure of tumor size as a guide for treatment response. The authors of the article on metastatic melanoma noted that tumor size did not relate to the amount of metabolically active cancer after 3-BP treatment. Even though the patient had a massive tumor burden after 3-BP treatment, it was almost entirely inactive.

The Nova Biomedical site makes clear claims about the accuracy and convenience of their lactate monitors.

http://www.novabiomedical.com/products/lactate-plus/ "" target="\_blank" rel="nofollow">http://www.novabiomedical.com/products/lactate-plus/ " target="\_blank" rel="nofollow">http://www.novabiomedical.com/products/lactate-plus/

We might contact them or post to a high performance athlete forum about these monitors.

I defer to those on these site of greater wisdom than I about these monitors. Any comments?
So would I measure right after a DCA IV?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Thu Apr 02, 2015 05:59 PM

Quote | Reply

On Apr 01, 2015 11:09 PM bella20 wrote:

yes, colon cancer met to liver and abdoment. After 4 months treatment at Dr. Munoz ( San Diego Clinic) all scans came out clear, But CEA still not in normal range, Now CEA is going  up but still don't see on Pet scan or MRI . That why he has to use another weapon to bring the CEA to normal.
Bella, ask your doctor if is a good idea to use 3BP treatment for something that is not visible on PET.

If there is nothing visible on PET but CEA goes up, it is either using other fuels such as glutamine or it is so small that is below the resolution limit of PET.

If it is the first, I would at least start taking EGCG, Metformin and if possible Phenylbutyrate.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Thu Apr 02, 2015 09:21 PM
Quote | ReplyJust checking the doses of ALA and HCA.  What I can see is that ALA is 1200 mg/day as it HCA.  However, my local health shop only stocks ALA as 120 mg/daily (Solgar).  So, I'm going to have to order it from overseas.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Apr 02, 2015 11:18 PM
Quote | ReplyThank you very much for the journal reference. I was not completely sure whether lactate would be helpful to measure. The metastatic melanoma patients LDH was measured which is not exactly the same as lactate.

Have any of the patients on the site had their lactate levels measured?

We have just been told that a family member had a lactic acid level of 3.8 mmol/L (normal 0.6-2.4 mmol/L) and a urea reading of 14 (normal 2.8-8.0 mmol/L). We are worried this might be cancer. Any advise would be appreciated.

Would there be any non-prescription suggestions that could be made to help out if this were cancer?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Thu Apr 02, 2015 11:25 PM
Quote | ReplyYou'd need to check creatinine to see if this is renal impairment.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Apr 02, 2015 11:31 PM
Quote | ReplyCreatinine 62 normal (reference 45-97 umol/L).

MCV, MCH slightly high.

Hemoblobin slightly low.

Everything else normal (e.g. hematology).

Worried about the lactic acid. No other illness could explain an elevated level.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by zhaosr on Fri Apr 03, 2015 12:01 AM
Quote | Replyhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975915/table/T1

Causes of a raised lactate.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Fri Apr 03, 2015 12:25 AM
Quote | ReplyThank you very much. This gives us some good leads. Will also increase fluid intake.
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# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Fri Apr 03, 2015 09:02 AM

Quote | Reply

On Apr 03, 2015 3:18 AM Jcancom wrote:

Thank you very much for the journal reference. I was not completely sure whether lactate would be helpful to measure. The metastatic melanoma patients LDH was measured which is not exactly the same as lactate.

Have any of the patients on the site had their lactate levels measured?

We have just been told that a family member had a lactic acid level of 3.8 mmol/L (normal 0.6-2.4 mmol/L) and a urea reading of 14 (normal 2.8-8.0 mmol/L). We are worried this might be cancer. Any advise would be appreciated.

Would there be any non-prescription suggestions that could be made to help out if this were cancer?
Iscador Vit C IVs curcumin Thymic protein A coffee enemas resveratrol

Sorry to hear this.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Fri Apr 03, 2015 12:45 PM

Quote | Reply

On Apr 03, 2015 3:18 AM Jcancom wrote:

Thank you very much for the journal reference. I was not completely sure whether lactate would be helpful to measure. The metastatic melanoma patients LDH was measured which is not exactly the same as lactate.

Have any of the patients on the site had their lactate levels measured?

We have just been told that a family member had a lactic acid level of 3.8 mmol/L (normal 0.6-2.4 mmol/L) and a urea reading of 14 (normal 2.8-8.0 mmol/L). We are worried this might be cancer. Any advise would be appreciated.

Would there be any non-prescription suggestions that could be made to help out if this were cancer?
Please keep us updated--if there is any way we can help, that is what we are here for!

Best to you!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Fri Apr 03, 2015 05:26 PM

Quote | Reply

On Apr 02, 2015 5:39 PM Jcancom wrote:

The original posting was in the context of TLS. It was suggested at that time that measuring lactate might be one way to monitor treatment response to 3-BP with a heavy tumor burden. Perhaps this wuold give an upstream measure of treatment response. For example, with the metastatic melanoma patient LDH appeared to be a key biomarker of treatment response.

Measuring lactate could also be used more broadly by cancer patients to assess treatment response. Often people might just use a simple measure of tumor size as a guide for treatment response. The authors of the article on metastatic melanoma noted that tumor size did not relate to the amount of metabolically active cancer after 3-BP treatment. Even though the patient had a massive tumor burden after 3-BP treatment, it was almost entirely inactive.

The Nova Biomedical site makes clear claims about the accuracy and convenience of their lactate monitors.

http://www.novabiomedical.com/products/lactate-plus/ "" target="\_blank" rel="nofollow">http://www.novabiomedical.com/products/lactate-plus/ " target="\_blank" rel="nofollow">http://www.novabiomedical.com/products/lactate-plus/

We might contact them or post to a high performance athlete forum about these monitors.

I defer to those on these site of greater wisdom than I about these monitors. Any comments?
Another set of options for your relative should it be cancer.

1. Immunotherapy; to stimulate the innate immune system;
	1. Coley's toxins - consists of heat-killed bacteria that stimulate the innate immune system to attack abnormal cells, including cancer.
	2. GcMAF is a macrophage activating factor that is normally inhibited by cancer cells. GcMAF activates macrophages to kill cancer cells.
	3. Interleukin-2 (Proleukin) is a substance produced by the body that stimulates production of cytotoxic T cells, which can kill cancer cells.
	4. GM-CSF (Leukine) stimulates the bone marrow to produce more granulocytes and macrophages. This recombinant drug has shown to be helpful in inhibiting cancer progression especially when given in conjunction with a vaccine.
	5. Whole body hyperthermia is a process where the patient is warmed to a temperature of up to 104 degrees Fahrenheit. Increased temperature stimulates increased innate immune function.
2. Glycolytic inhibitors; DCA, or dichloroacetate inhibits the cancer cells' ability to utilize sugar, while promoting normal mitochondrial oxidative phosphorylation (cancer cells that use oxidative phosphorylation are more susceptible to being destroyed).
3. Matrix metalloproteinase inhibitor (MMPI); cancer cells "dig in" to normal tissue by secreting an enzyme that breaks down this tissue. Doxycycline (a commonly used antibiotic), in higher doses than typically used for infection, inhibits release of this enzyme.
4. 5-alpha reductase inhibitors; Dutasteride (Avodart) is a 5-alpha reductase-1 and 2 inhibitor used in high doses for "hormone refractory prostate cancer."
5. Cox-2 inhibitor; cox-2 inhibitors (Celebrex) promote apoptosis, or programmed cell death in cancer cells. Synergy has been seen when combined with doxycycline, the MMPI.
6. Angiogenesis inhibitors
	1. Ammonium tetrathiomolybdate; tumors can not grow without sprouting new vessels. Vessel formation is dependent on adequate amounts of copper; if copper is depleted, tumors can not develop more blood vessels. Ammonium tetrathiomolybdate chelates copper, thereby inhibiting angiogenesis.
	2. Low molecular weight heparins (normally used when patients develop blood clots) inhibit metastases by interfering with the binding of cancer cells to platelets (cancer cells often attach themselves to platelets for transport to another location).
7. Cancer cell cytotoxic agents; vitamin C, at high doses intravenously, when used with vitamin K3 at a ratio of 100:1, is preferentially cytotoxic to cancer cells, while leaving normal cells unharmed. Oncologists will often tell patients not to take vitamin C because it is an anti-oxidant and it will interfere with the effectiveness of chemotherapy. These oncologists are unaware that at high doses, vitamin C acts as a pro-oxidant in cancer cells, leading to cancer cell death.
8. Mitosis inhibitors; cancer cells divide rapidly through a process called mitosis. Mitosis occurs through a process known as spindle formation. During spindle formation, spindles pull the chromosomes to opposite sides of the cell, in preparation for cell division. Noscapine, an opioid agonist binds to the spindles, inhibiting mitosis.
9. Aromatase inhibitors; research has shown that several cancers, including breast, cervical, uterine, lung, prostate, and colorectal, often fuel their growth through the production of estrogen. Aromatase inhibitors block production of estrogen.
10. IGF-1; IGF-1, or insulin-like growth factor-1 is a growth factor that often fuels cancer growth. Octreotide inhibits the production of IGF-1.
11. GnRh agonists; GnRh agonists, or gonadotropin releasing hormone agonists may inhibit cancer in 2 ways. GnRh inhibits production of the sex steroids; if the cancer is dependent on sex steroids, GnRh will slow cancer growth. In addition, many cancers have receptors for GnRh, which when stimulated, inhibit cancer growth.
12. Vitamin D2 analogues; vitamin D, as is mentioned below under the heading, "Vitamins and Supplements," inhibits cancer growth through multiple mechanisms, in a dose-dependent fashion. The higher the dose of vitamin D, the greater the cancer suppression. The problem with giving high dose intravenous vitamin D3 (this is the type of vitamin D that we normally consume), is that it can cause dangerously elevated vitamin D levels. Vitamin D2 analogues, such as paricalcitol and hectorol, inhibit cancer as effectively as vitamin D3 without increasing calcium levels.

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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Fri Apr 03, 2015 05:41 PM
Quote | ReplyGreat informative post, Genelle!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Fri Apr 03, 2015 05:41 PM
Quote | ReplyVery nice list Genelle! Wouldl be great if you could add the source where you can get each of the item, for the cases where you have a source.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Fri Apr 03, 2015 06:03 PM
Quote | ReplyRosenberg Integrative Cancer Treatment
and Research Institute
4800 N. Federal Hwy, Suite B306
Boca Raton, FL 33431
[View map]

Please send donations by check to:
1730 S. Federal Highway, Box 340
Delray Beach, FL 33483

Vitamins and Supplements

1. Vitamin D3; vitamin D inhibits cancer growth through multiple mechanisms; it inhibits the release of proteinases from cancer cells, such as matrix metalloproteinase and cathepsin; it inhibits IGF-1 stimulated growth; it arrests the cancer cell growth cycle. Also, many cancer cells have vitamin D receptors, which inhibit cell growth when bound to vitamin D.
2. Avemar; fermented wheat germ extract that has shown to inhibit cancer growth through multiple mechanisms; it inhibits DNA synthesis, improves natural killer cell activity, and promotes apoptosis (programmed cell death) in almost every cancer cell line studied.
3. Melatonin; inhibits cancer growth through multiple mechanisms; interferes with activation of the estrogen receptor; inhibits telomerase activity in cancer cells (telomerase keeps the cancer cells immortal); promotes apoptosis (programmed cell death); stimulates cytotoxic activity of macrophages.
4. Curcumin; inhibits cancer growth through multiple mechanisms; interferes with activation of the estrogen receptor; inhibits nuclear factor kappa beta; inhibits cyclooxygenase and lipooxygenase pathways; promotes apoptosis in cancer cells.
5. Lycopene; inhibits cancer growth through multiple mechanisms. Most of the research has been done with prostate cancer, but lycopene has shown to inhibit growth of most cancers studied in a dose-dependent fashion.
6. Green tea extract; promotes apoptosis in almost every cancer cell line studied; blocks the aryl hydrocarbon receptor, which activates oncogenes (cancer promoting genes); inhibits VEGF (a potent factor that helps cancer cells develop their blood supply

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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Fri Apr 03, 2015 06:30 PM
Quote | ReplyPharmacokinetics of oral vit c http://www.canceraction.org.gg/system/files/Hickey-Liposomal  Vit c and cancer, is there a use for oral vit c http://www.csom.ca/wp-content/uploads/2013/03/Vitamin-C-and-  The real story of vit c and cancer http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  It would seem a single 36g dose of liposomal vit c can result in a peak plasma level of 400μM/L over the course of 6 hours. Published results for a one-hour In vitro test on human Burkitt's lymphoma cells, using AA at 300μM/L showed 30% necrosis and apoptosis and 400μM/L increases this to almost 50%. This key is keeping this up every 6 hours. Also in combo with IV vit c, IV and oral ALA, IV vit k3, oral selenium http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  and oral salvestrols http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv
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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Fri Apr 03, 2015 06:33 PM
Quote | ReplyCurcumin can't be used with vit c as it stops the Fenton reaction
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Fri Apr 03, 2015 06:33 PM

Quote | Reply

On Apr 03, 2015 10:30 PM james-peters wrote:

Pharmacokinetics of oral vit c http://www.canceraction.org.gg/system/files/Hickey-Liposomal %20vit%20C.pdf"" target="\_blank" rel="nofollow">http://www.canceraction.org.gg/system/files/Hickey-Liposomal  target="\_blank" rel="nofollow">http://www.canceraction.org.gg/system/files/Hickey-Liposomal  Vit c and cancer, is there a use for oral vit c http://www.csom.ca/wp-content/uploads/2013/03/Vitamin-C-and- Cancer-Is-There-A-Use-For-Oral-Vitamin-C-28.1.pdf"" target="\_blank" rel="nofollow">http://www.csom.ca/wp-content/uploads/2013/03/Vitamin-C-and-  target="\_blank" rel="nofollow">http://www.csom.ca/wp-content/uploads/2013/03/Vitamin-C-and-  The real story of vit c and cancer http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan dCancer2\_Hickey.pdf"" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  It would seem a single 36g dose of liposomal vit c can result in a peak plasma level of 400μM/L over the course of 6 hours. Published results for a one-hour In vitro test on human Burkitt's lymphoma cells, using AA at 300μM/L showed 30% necrosis and apoptosis and 400μM/L increases this to almost 50%. This key is keeping this up every 6 hours. Also in combo with IV vit c, IV and oral ALA, IV vit k3, oral selenium http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against -Cancer/Page-01"" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  and oral salvestrols http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv ivors-jeffrey-dach/"" target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv
Check out Dr Jean Drisko at U Kansas who did all te research on IV Vit C.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Fri Apr 03, 2015 06:51 PM
Quote | ReplyThank you very much everyone for all your suggestions and good wishes.

Hopefully, we will soon have a better idea what is going on. I am happy that this thread has so many good ideas that could be used, if necessary, to help us out.

It is especially comforting to know that 3-BP is available. In particular, an early stage tumor would avoid all the problems of TLS that we have discussed here.

# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Fri Apr 03, 2015 07:21 PM

Quote | Reply

On Apr 03, 2015 10:30 PM james-peters wrote:

Pharmacokinetics of oral vit c http://www.canceraction.org.gg/system/files/Hickey-Liposomal %20vit%20C.pdf"" target="\_blank" rel="nofollow">http://www.canceraction.org.gg/system/files/Hickey-Liposomal  target="\_blank" rel="nofollow">http://www.canceraction.org.gg/system/files/Hickey-Liposomal  Vit c and cancer, is there a use for oral vit c http://www.csom.ca/wp-content/uploads/2013/03/Vitamin-C-and- Cancer-Is-There-A-Use-For-Oral-Vitamin-C-28.1.pdf"" target="\_blank" rel="nofollow">http://www.csom.ca/wp-content/uploads/2013/03/Vitamin-C-and-  target="\_blank" rel="nofollow">http://www.csom.ca/wp-content/uploads/2013/03/Vitamin-C-and-  The real story of vit c and cancer http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan dCancer2\_Hickey.pdf"" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  It would seem a single 36g dose of liposomal vit c can result in a peak plasma level of 400μM/L over the course of 6 hours. Published results for a one-hour In vitro test on human Burkitt's lymphoma cells, using AA at 300μM/L showed 30% necrosis and apoptosis and 400μM/L increases this to almost 50%. This key is keeping this up every 6 hours. Also in combo with IV vit c, IV and oral ALA, IV vit k3, oral selenium http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against -Cancer/Page-01"" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  and oral salvestrols http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv ivors-jeffrey-dach/"" target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv
I have a question about liposomal Vit. C.--hoping someone much more knowledgeable than I am with it can assist me.

After reading this interesting post, I googled about this type of Vitamin. C.  Everyone apparently seems to prefer the LivOn Labortories brand, etc.

But, upon reading the ingredients of this product, I noticed that one of the components is "Essential phospholipids"--comprised  from soy lecithin.

Having breast cancer, I have been told that the only soy I should ingest should be fermented soy--i.e., Haelen, Avemar, etc.

So any thoughts about the usage of liposomal Vit. C since it contains soy lecithin?  Would appreciate any feedback.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Fri Apr 03, 2015 11:08 PM
Quote | ReplyLet me make a correction!  Avemar is wheat--not soy..
Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterGenelle

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Sat Apr 04, 2015 10:28 AM

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On Apr 03, 2015 11:21 PM jetsparkle wrote:

On Apr 03, 2015 10:30 PM james-peters wrote:

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rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" 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rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  It would seem a single 36g dose of liposomal vit c can result in a peak plasma level of 400μM/L over the course of 6 hours. Published results for a one-hour In vitro test on human Burkitt's lymphoma cells, using AA at 300μM/L showed 30% necrosis and apoptosis and 400μM/L increases this to almost 50%. This key is keeping this up every 6 hours. Also in combo with IV vit c, IV and oral ALA, IV vit k3, oral selenium http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  -Cancer/Page-01"" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" 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rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  and oral salvestrols http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv "" target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  "" target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv "" target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv "" target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  "" target="\_blank" 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I have a question about liposomal Vit. C.--hoping someone much more knowledgeable than I am with it can assist me.

After reading this interesting post, I googled about this type of Vitamin. C.  Everyone apparently seems to prefer the LivOn Labortories brand, etc.

But, upon reading the ingredients of this product, I noticed that one of the components is "Essential phospholipids"--comprised  from soy lecithin.

Having breast cancer, I have been told that the only soy I should ingest should be fermented soy--i.e., Haelen, Avemar, etc.

So any thoughts about the usage of liposomal Vit. C since it contains soy lecithin?  Would appreciate any feedback.
I have taken liposomal glutathione because apparently regular glutathione is not useful acording to my doctor and it is better to take a precurser. I think one of the posts on 3BP was about encapsulating it for delivery. I think you could use different kinds of material so if it did have soy you could lfind one with a different coating. Vit c is water soluable but there is an oil sol version called  ascorbyl palmitate.I am not sure why a person would need the lipo form. I do IVs of C as well.Curr Drug Deliv. 2007 Oct;4(4):297-305.Liposomal drug delivery systems: an update review.Samad A1, Sultana Y, Aqil M.Author informationAbstractThe discovery of liposome or lipid vesicle emerged from self forming enclosed lipid bi-layer upon hydration; liposome drug delivery systems have played a significant role in formulation of potent drug to improve therapeutics. Recently the liposome formulations are targeted to reduce toxicity and increase accumulation at the target site. There are several new methods of liposome preparation based on lipid drug interaction and liposome disposition mechanism including the inhibition of rapid clearance of liposome by controlling particle size, charge and surface hydration. Most clinical applications of liposomal drug delivery are targeting to tissue with or without expression of target recognition molecules on lipid membrane. The liposomes are characterized with respect to physical, chemical and biological parameters. The sizing of liposome is also critical parameter which helps characterize the liposome which is usually performed by sequential extrusion at relatively low pressure through polycarbonate membrane (PCM). This mode of drug delivery lends more safety and efficacy to administration of several classes of drugs like antiviral, antifungal, antimicrobial, vaccines, anti-tubercular drugs and gene therapeutics. Present applications of the liposomes are in the immunology, dermatology, vaccine adjuvant, eye disorders, brain targeting, infective disease and in tumour therapy. The new developments in this field are the specific binding properties of a drug-carrying liposome to a target cell such as a tumor cell and specific molecules in the body (antibodies, proteins, peptides etc.); stealth liposomes which are especially being used as carriers for hydrophilic (water soluble) anticancer drugs like doxorubicin, mitoxantrone; and bisphosphonate-liposome mediated depletion of macrophages. This review would be a help to the researchers working in the area of liposomal drug delivery.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Sat Apr 04, 2015 10:50 AM
Quote | ReplySo it looks like you are going for high blood level. That is why i do IV Vit C to change it from anti to prooxidant to kill cancer. I have spoken to Dr Drisko about her research on this and I know she is good with some oral C and some other vitamins. She says in the interview they noticed Vit B can interfere so I do not do vitamins when I do the IVs.

http://www.prescription2000.com/Interview-Transcripts/2011-0

Molecular and Clinical Nutrition Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Md 20892-1372, USA.

Early clinical studies showed that high-dose vitamin C, given by intravenous and oral routes, may improve symptoms and prolong life in patients with terminal cancer. Double-blind placebo-controlled studies of oral vitamin C therapy showed no benefit. Recent evidence shows that oral administration of the maximum tolerated dose of vitamin C (18 g/d) produces peak plasma concentrations of only 220 micromol/L, whereas intravenous administration of the same dose produces plasma concentrations about 25-fold higher. Larger doses (50-100 g) given intravenously may result in plasma concentrations of about 14,000 micromol/L. At concentrations above 1000 micromol/L, vitamin C is toxic to some cancer cells but not to normal cells in vitro. We found 3 well-documented cases of advanced cancers, confirmed by histopathologic review, where patients had unexpectedly long survival times after receiving high-dose intravenous vitamin C therapy. We examined clinical details of each case in accordance with National Cancer Institute (NCI) Best Case Series guidelines. Tumour pathology was verified by pathologists at the NCI who were unaware of diagnosis or treatment. In light of recent clinical pharmacokinetic findings and in vitro evidence of anti-tumour mechanisms, these case reports indicate that the role of high-dose intravenous vitamin C therapy in cancer treatment should be reassessed.

europe.org /files/080807\_RealStoryOfVitaminCan It would seem a single 36g dose of liposomal vit c can result in a peak plasma level of 400μM/L over the course of 6 hours. Published results for a one-hour In vitro test on human Burkitt's lymphoma cells, using AA at 300μM/L showed 30% necrosis and apoptosis and 400μM/L increases this to almost 50%. This key is keeping this up every 6 hours. Also in combo with IV vit c, IV and oral ALA, IV vit k3, oral selenium
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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Sat Apr 04, 2015 03:50 PM

Quote | Reply

On Apr 03, 2015 11:21 PM jetsparkle wrote:

On Apr 03, 2015 10:30 PM james-peters wrote:

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rel="nofollow">http://www.canceraction.org.gg/system/files/Hickey-Liposomal  Vit c and cancer, is there a use for oral vit c http://www.csom.ca/wp-content/uploads/2013/03/Vitamin-C-and- "" target="\_blank" rel="nofollow">http://www.csom.ca/wp-content/uploads/2013/03/Vitamin-C-and-  target="\_blank" rel="nofollow">http://www.csom.ca/wp-content/uploads/2013/03/Vitamin-C-and-  "" target="\_blank" rel="nofollow">http://www.csom.ca/wp-content/uploads/2013/03/Vitamin-C-and- "" target="\_blank" rel="nofollow">http://www.csom.ca/wp-content/uploads/2013/03/Vitamin-C-and-  target="\_blank" rel="nofollow">http://www.csom.ca/wp-content/uploads/2013/03/Vitamin-C-and-  target="\_blank" rel="nofollow">http://www.csom.ca/wp-content/uploads/2013/03/Vitamin-C-and- "" target="\_blank" rel="nofollow">http://www.csom.ca/wp-content/uploads/2013/03/Vitamin-C-and-  target="\_blank" rel="nofollow">http://www.csom.ca/wp-content/uploads/2013/03/Vitamin-C-and-  "" target="\_blank" 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rel="nofollow">http://www.csom.ca/wp-content/uploads/2013/03/Vitamin-C-and-  target="\_blank" rel="nofollow">http://www.csom.ca/wp-content/uploads/2013/03/Vitamin-C-and-  The real story of vit c and cancer http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  dCancer2\_Hickey.pdf"" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan "" target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  target="\_blank" rel="nofollow">http://www.anh-europe.org/files/080807\_RealStoryOfVitaminCan  It would seem a single 36g dose of liposomal vit c can result in a peak plasma level of 400μM/L over the course of 6 hours. Published results for a one-hour In vitro test on human Burkitt's lymphoma cells, using AA at 300μM/L showed 30% necrosis and apoptosis and 400μM/L increases this to almost 50%. This key is keeping this up every 6 hours. Also in combo with IV vit c, IV and oral ALA, IV vit k3, oral selenium http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  -Cancer/Page-01"" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" 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rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against "" target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  target="\_blank" rel="nofollow">http://www.lef.org/Magazine/2012/SS/Selenium-Protect-Against  and oral salvestrols http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv "" target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  "" target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv "" target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv "" target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  "" target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv "" target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  "" target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv "" target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv "" target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv "" target="\_blank" 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rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  "" target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv "" target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv "" target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  "" target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv "" target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  target="\_blank" rel="nofollow">http://jeffreydachmd.com/2013/06/salvestrols-for-cancer-surv  "" target="\_blank" 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I have a question about liposomal Vit. C.--hoping someone much more knowledgeable than I am with it can assist me.

After reading this interesting post, I googled about this type of Vitamin. C.  Everyone apparently seems to prefer the LivOn Labortories brand, etc.

But, upon reading the ingredients of this product, I noticed that one of the components is "Essential phospholipids"--comprised  from soy lecithin.

Having breast cancer, I have been told that the only soy I should ingest should be fermented soy--i.e., Haelen, Avemar, etc.

So any thoughts about the usage of liposomal Vit. C since it contains soy lecithin?  Would appreciate any feedback.
It may all depend on the amounts used. Generally most are small and don't contribute a substantial level of phytoestrogens. Some brands may use higher levels and some may use sunflower lecithin
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Sun Apr 05, 2015 12:11 AM
Quote | ReplyThank you both for your informative replies--appreciate them.  Will investigate further, too.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Sun Apr 05, 2015 02:17 AM
Quote | ReplyThere is a company in Japan who makes GcMAF, they operate a number of clinics. However they use it along with other treatments like local (and wholebody) hyperthermia using the thermotron rf8 http://www.ncbi.nlm.nih.gov/pubmed/2928494  http://www.ncbi.nlm.nih.gov/pubmed/3756783  PDT, SDT, Coley's Toxins, IV Vit C, High-intensity focused ultrasound and Autologous immune enhancement therapy
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Sun Apr 05, 2015 03:17 AM
Quote | ReplyGreat information.  I am very interested in 3-BP--however, tumor burden is quite high right now.  So care would have to be taken because of TLS.  But I am not a candidate for surgery either--been there, done that--and too much inflammation/spreading of cancer to axillary lymph nodes and supraclavicular areas--then some mets to spine.

But cryoablation and loco-regional hyperthermia prospects (although $$$)--whole body hyperthermia very difficult to handle--tried a few times.  Do not know where clinics in U.S. offer the loco-regional version or high-intensity focused ultrasound. Was not aware of the Thermotron usage--wondering if one has to have radiation in conjunction first--that would be a definite "no" for me then.

Appreciate all of the information about keto diet, metformin, DCA, 3-BP on this thread--metabolic therapy is the way to go.

Was reading just the other day about something Cornerstone Pharmaceuticals (cornerstonepharma.com) is offering--AEMD/CPI-613.  Apparently they are on the metabolism bandwagon--doing clinical trials. Targeting enzymes involved in cancer cell enery metabolism that are located in the mitochondria.  I am more wary when a pharmaceutical company is involved--but will continue to watch their results, too.

In any event, information I am gleaning from this thread is very encouraging to me--thanks everyone!
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Apr 05, 2015 06:06 AM

Quote | Reply

On Apr 03, 2015 1:21 AM zhaosr wrote:

Just checking the doses of ALA and HCA.  What I can see is that ALA is 1200 mg/day as it HCA.  However, my local health shop only stocks ALA as 120 mg/daily (Solgar).  So, I'm going to have to order it from overseas.
Here is 600mg/capsule: http://www.iherb.com/Doctor-s-Best-Best-Alpha-Lipoic-Acid-60

Some say R-Lipoic Acid is better: http://www.iherb.com/Life-Extension-Super-R-Lipoic-Acid-240-
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Apr 05, 2015 06:11 AM

Quote | Reply

On Apr 03, 2015 10:33 PM james-peters wrote:

Curcumin can't be used with vit c as it stops the Fenton reaction
James, this is interesting and important statement. Can you add a reference to support this statement?

# Anyone used 3bp (3-bromopyruvate)?

View all Alternative Treatments Discussions Post A New Discussion902 Posts | Page(s): Prev 12...55 56 57 58 59 ...9091 Next Danielus

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Apr 05, 2015 06:15 AM
Quote | ReplyCan anyone help with suggesting a good place for cryoablation in Europe?
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Sun Apr 05, 2015 08:04 AM

Quote | Reply

On Apr 05, 2015 7:17 AM jetsparkle wrote:

Great information.  I am very interested in 3-BP--however, tumor burden is quite high right now.  So care would have to be taken because of TLS.  But I am not a candidate for surgery either--been there, done that--and too much inflammation/spreading of cancer to axillary lymph nodes and supraclavicular areas--then some mets to spine.

But cryoablation and loco-regional hyperthermia prospects (although $$$)--whole body hyperthermia very difficult to handle--tried a few times.  Do not know where clinics in U.S. offer the loco-regional version or high-intensity focused ultrasound. Was not aware of the Thermotron usage--wondering if one has to have radiation in conjunction first--that would be a definite "no" for me then.

Appreciate all of the information about keto diet, metformin, DCA, 3-BP on this thread--metabolic therapy is the way to go.

Was reading just the other day about something Cornerstone Pharmaceuticals (cornerstonepharma.com) is offering--AEMD/CPI-613.  Apparently they are on the metabolism bandwagon--doing clinical trials. Targeting enzymes involved in cancer cell enery metabolism that are located in the mitochondria.  I am more wary when a pharmaceutical company is involved--but will continue to watch their results, too.

In any event, information I am gleaning from this thread is very encouraging to me--thanks everyone!
All these metabolic therapies seem to be about mitochondrial  issues. I am going to try to find out how MitoQ would work if added to the DCA KETO Metformin protocol since the post that said it would kill breast cancer.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by jetsparkle on Sun Apr 05, 2015 11:12 AM
Quote | ReplyWill await any of your findings about  adding MitoQ to that protocol, Genelle.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Sun Apr 05, 2015 12:38 PM
Quote | ReplyResearchers at Huntsman Cancer Institute say modified ...fox13now.com /.../**researchers**-at-huntsman-**cancer**-institute-say-mo...\*
fox13now.com " data-async-trigger="cra-2-filled" data-ved="0CDYQ5CswAg">KSTUfox13now.com " data-async-trigger="cra-2-filled" data-ved="0CDYQ5CswAg">SALT LAKE CITY — Utah has the highest rate of melanoma cases in the nation, and now researchers at the Huntsman Cancer Institute said they may be close to finding a cure using a process that involves injecting live viruses into the patient’s skin.

What we do with this treatment, we take the virus… this is not the common virus; we take these viruses for herpes, others are cold viruses, and what we do is change the way these viruses work,” Andtbacka said
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Sun Apr 05, 2015 12:41 PM
Quote | ReplyUsing antibodies from camels and alpacas, scientists at Washington University School of Medicine in St. Louis have found a way to deliver anticancer viruses directly to tumor cells, leaving other types of cells uninfected.

Camel, alpaca antibodies target anticancer viruses directly ...news.wu **stl**.edu/.../camel-alpaca-antib...\*
news.wu stl.edu" data-async-trigger="cra-1-filled" data-ved="0CCoQ5CswAQ">Washington University in St. Louisnews.wu stl.edu" data-async-trigger="cra-1-filled" data-ved="0CCoQ5CswAQ">Quote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterjames-peters

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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Sun Apr 05, 2015 05:09 PM

Quote | Reply

On Apr 05, 2015 7:17 AM jetsparkle wrote:

Great information.  I am very interested in 3-BP--however, tumor burden is quite high right now.  So care would have to be taken because of TLS.  But I am not a candidate for surgery either--been there, done that--and too much inflammation/spreading of cancer to axillary lymph nodes and supraclavicular areas--then some mets to spine.

But cryoablation and loco-regional hyperthermia prospects (although $$$)--whole body hyperthermia very difficult to handle--tried a few times.  Do not know where clinics in U.S. offer the loco-regional version or high-intensity focused ultrasound. Was not aware of the Thermotron usage--wondering if one has to have radiation in conjunction first--that would be a definite "no" for me then.

Appreciate all of the information about keto diet, metformin, DCA, 3-BP on this thread--metabolic therapy is the way to go.

Was reading just the other day about something Cornerstone Pharmaceuticals (cornerstonepharma.com) is offering--AEMD/CPI-613.  Apparently they are on the metabolism bandwagon--doing clinical trials. Targeting enzymes involved in cancer cell enery metabolism that are located in the mitochondria.  I am more wary when a pharmaceutical company is involved--but will continue to watch their results, too.

In any event, information I am gleaning from this thread is very encouraging to me--thanks everyone!
You don't have to have radio with local hyperthermia/HIFU however they have a synergistic effect together, be it reg or low dose. You could look into radiofrequency/microwave ablation or the nanoknife (irreversible electroporation) but these would require an anesthetic as would cryoablation
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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Sun Apr 05, 2015 05:11 PM

Quote | Reply

On Apr 05, 2015 4:38 PM Genelle wrote:

Researchers at Huntsman Cancer Institute say modified ...fox13now.com " target="\_blank" rel="nofollow">fox13now.com  " target="\_blank" rel="nofollow">fox13now.com " target="\_blank" rel="nofollow">fox13now.com  "" target="\_blank" rel="nofollow">http://fox13now.com " target="\_blank" rel="nofollow">fox13now.com  " target="\_blank" rel="nofollow">fox13now.com " target="\_blank" rel="nofollow">fox13now.com  " " target="\_blank" rel="nofollow">fox13now.com " target="\_blank" rel="nofollow">fox13now.com  " target="\_blank" rel="nofollow">fox13now.com " target="\_blank" rel="nofollow">fox13now.com  "" target="\_blank" rel="nofollow">http://fox13now.com " target="\_blank" rel="nofollow">fox13now.com  " target="\_blank" rel="nofollow">fox13now.com " target="\_blank" rel="nofollow">fox13now.com  " " target="\_blank" rel="nofollow">fox13now.com " target="\_blank" rel="nofollow">fox13now.com  " target="\_blank" rel="nofollow">fox13now.com " target="\_blank" rel="nofollow">fox13now.com  "" target="\_blank" rel="nofollow">http://fox13now.com " target="\_blank" rel="nofollow">fox13now.com  " target="\_blank" rel="nofollow">fox13now.com " target="\_blank" rel="nofollow">fox13now.com  " " target="\_blank" rel="nofollow">fox13now.com " target="\_blank" rel="nofollow">fox13now.com  " target="\_blank" rel="nofollow">fox13now.com " target="\_blank" rel="nofollow">fox13now.com  "" target="\_blank" rel="nofollow">http://fox13now.com " target="\_blank" rel="nofollow">fox13now.com  " target="\_blank" rel="nofollow">fox13now.com " target="\_blank" rel="nofollow">fox13now.com  " target="\_blank" rel="nofollow">fox13now.com " target="\_blank" rel="nofollow">fox13now.com  " target="\_blank" rel="nofollow">fox13now.com " target="\_blank" rel="nofollow">fox13now.com  /.../**researchers**-at-huntsman-**cancer**-institute-say-mo...\*
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What we do with this treatment, we take the virus… this is not the common virus; we take these viruses for herpes, others are cold viruses, and what we do is change the way these viruses work,” Andtbacka said
The objective response rate (any response) with T-VEC was 26%, with 11% of patients experiencing a complete response (complete disappearance of melanoma throughout the body) http://en.wikipedia.org/wiki/Talimogene\_laherparepvec  Adding an Anti-CTLA4 (ipilimumab) plus T-VEC was 56% (ORR), with 33% of patients experiencing a complete response http://wwwext.amgen.com/media/media\_pr\_detail.jsp?releaseID=  With an Anti-PD1 (nivolumab is better than pembrolizumab) ORR could be over 60/70%+ and complete response could be 40/50%+ Using all three would be even better. Also other checkpoint inhibitors are being looked at like anti-CD47, TIM3, LAG3, OX40, IDO and so on. Other oncolytic viruses are being looked at too (some better than T-VEC) http://en.wikipedia.org/wiki/Oncolytic\_virus#Clinical\_resear
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### RE: Anyone used 3bp (3-bromopyruvate)?

by james-peters on Sun Apr 05, 2015 05:13 PM

Quote | Reply

On Apr 05, 2015 10:11 AM Danielus wrote:

On Apr 03, 2015 10:33 PM james-peters wrote:

Curcumin can't be used with vit c as it stops the Fenton reaction
James, this is interesting and important statement. Can you add a reference to support this statement?
I will look for some. IP6, curcumin and certain others may bind iron, the resulting reducing state makes cancer cells less able to proliferate and grow. Vit c redox therapy works in the opposite way to these; it kills cancer cells by making them more oxidising. When iron or copper and vit c combine, they generate hydrogen peroxide in cancer cells. However if the iron has been removed by these, this reaction (Fenton) may be prevented. A reducing state is the opposite of an oxidising state. In a reducing enviroment, there are 'spare' electrons, to neutralise free radicals. In an oxidising environment, electrons get 'stolen', creating damaging free radicals.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Sun Apr 05, 2015 05:21 PM
Quote | ReplyYou could look into cyberknife. A friend had a lung tumor and it was gone after a 3 day treatment. Not much in the way of side effects.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Apr 05, 2015 05:27 PM

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On Apr 05, 2015 9:13 PM james-peters wrote:

On Apr 05, 2015 10:11 AM Danielus wrote:

On Apr 03, 2015 10:33 PM james-peters wrote:

Curcumin can't be used with vit c as it stops the Fenton reaction
James, this is interesting and important statement. Can you add a reference to support this statement?
I will look for some. IP6, curcumin and certain others may bind iron, the resulting reducing state makes cancer cells less able to proliferate and grow. Vit c redox therapy works in the opposite way to these; it kills cancer cells by making them more oxidising. When iron or copper and vit c combine, they generate hydrogen peroxide in cancer cells. However if the iron has been removed by these, this reaction (Fenton) may be prevented. A reducing state is the opposite of an oxidising state. In a reducing enviroment, there are 'spare' electrons, to neutralise free radicals. In an oxidising environment, electrons get 'stolen', creating damaging free radicals.
I did not knwo that Curcumin binds Iron. If that is true than I understand your statement about not combining the two ... on teh other hand Curcumin has so many anti-cancer actions that I would not wonder if is a pro oxidant as well once is in the cancer cell.

# Anyone used 3bp (3-bromopyruvate)?

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Sun Apr 05, 2015 06:00 PM
Quote | ReplyI have read cancer needs iron.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Apr 05, 2015 06:12 PM

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On Apr 05, 2015 10:00 PM Genelle wrote:

I have read cancer needs iron.
Indeed, this is why many alternative anti-cancer treatments such as Artemisinin, high dose Vit C, Gallium, etc. may work.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Apr 05, 2015 06:12 PM

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On Apr 05, 2015 10:00 PM Genelle wrote:

I have read cancer needs iron.
Indeed, this is why many alternative anti-cancer treatments such as Artemisinin, high dose Vit C, Gallium, etc. may work.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Sun Apr 05, 2015 06:16 PM
Quote | ReplySo you are saying we need it for Vit C to work? Lactoferrin will regulate iron.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Apr 05, 2015 06:24 PM

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On Apr 05, 2015 10:16 PM Genelle wrote:

So you are saying we need it for Vit C to work? Lactoferrin will regulate iron.
I would say cancer cells needs it to work and devide :)

But yes, the theraphies like Artemisnin or Vit C also needs that. While some are considering adding Iron supplements before e.g. Artemisinin, I think that is dangerous.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Sun Apr 05, 2015 06:28 PM
Quote | ReplyWell then I really need to reexamine my research because I thought you needed to eliminate iron for cancer.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Sun Apr 05, 2015 06:34 PM

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On Apr 05, 2015 10:24 PM Danielus wrote:

On Apr 05, 2015 10:16 PM Genelle wrote:

So you are saying we need it for Vit C to work? Lactoferrin will regulate iron.
I would say cancer cells needs it to work and devide :)

But yes, the theraphies like Artemisnin or Vit C also needs that. While some are considering adding Iron supplements before e.g. Artemisinin, I think that is dangerous.
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Send to: Sci Rep. 2014 Aug 5;4:5955. doi: 10.1038/srep05955.Extracellular iron diminishes anticancer effects of vitamin C: an in vitro study.Mojic M1, Bogdanovic Pristov J2, Maksimovic-Ivanic D1, Jones DR3, Stanic M2, Mijatovic S1, Spasojevic I2.Author informationAbstractIn vitro studies have shown that hydrogen peroxide (H2O2) produced by high-concentration ascorbate and cell culture medium iron efficiently kills cancer cells. This provided the rationale for clinical trials of high-dose intravenous ascorbate-based treatment for cancer. A drawback in all the in vitro studies was their failure to take into account the in vivo concentration of iron to supplement cell culture media which are characterized by low iron content. Here we showed, using two prostate cancer cell lines (LNCaP and PC-3) and primary astrocytes, that the anticancer/cytotoxic effects of ascorbate are completely abolished by iron at physiological concentrations in cell culture medium and human plasma. A detailed examination of mechanisms showed that iron at physiological concentrations promotes both production and decomposition of H2O2. The latter is mediated by Fenton reaction and prevents H2O2 accumulation. The hydroxyl radical, which is produced in the Fenton reaction, is buffered by extracellular proteins, and could not affect intracellular targets like H2O2. These findings show that anticancer effects of ascorbate have been significantly overestimated in previous in vitro studies, and that common cell culture media might be unsuitable for redox research.
PMID: 25092529 [PubMed - in process] PMCID: PMC4121606 Free PMC ArticleQuote | ReplyMore Sharing ServicesShare Share on email Share on facebook Share on twitterDanielus

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### RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Apr 05, 2015 06:36 PM
Quote | ReplyGenelle, I think using iron chelators such as Baicalein is just another route in fighting cancer. I do not think that is wrong, is just a different strategy.
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Sun Apr 05, 2015 06:38 PM
Quote | ReplyOK maybe there is evidence both ways.

http://www.prescription2000.com/Interview-Transcripts/2011-0
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### RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Sun Apr 05, 2015 06:39 PM
Quote | Replyhttp://www.prescription2000.com/Interview-Transcripts/2011-0