Rat

**Rats** are various medium-sized, long-tailed rodents in the superfamily Muroidea.

"True rats" are members of the genus *Rattus*, the most important of which to humans are the black rat, *Rattus rattus*, and the brown rat, *Rattus norvegicus*. Many members of other rodent genera and families are also referred to as rats, and share many characteristics with true rats.

Rats are typically distinguished from mice by their size. Generally, when someone discovers a large muroid rodent, its common name includes the term *rat*, while if it is smaller, the name includes the term *mouse*. The muroid family is broad and complex, and the common terms *rat* and *mouse* are not taxonomically specific. Scientifically, the terms are not confined to members of the *Rattus* and *Mus* genera, for example, the pack rat and cotton mouse.

## Species & Description

The best-known rat species are the black rat (*Rattus rattus*) and the brown rat (*Rattus norvegicus*). The group is generally known as the Old World rats or true rats, and originated in Asia. Rats are bigger than most Old World mice, which are their relatives, but seldom weigh over 500 grams (1.1 lb) in the wild.[1]

The term "rat" is also used in the names of other small mammals which are not true rats. Examples include the North American pack rats, a number of species loosely called kangaroo rats, and others. Rats such as the bandicoot rat(*Bandicota bengalensis*) are murine rodents related to true rats, but are not members of the genus *Rattus*. Male rats are called bucks, unmated females are called does, pregnant or parent females are called dams, and infants are called kittens or pups. A group of rats is referred to as a mischief.

The common species are opportunistic survivors and often live with and near humans; therefore, they are known as commensals. They may cause substantial food losses, especially in developing countries. However, the widely distributed and problematic commensal species of rats are a minority in this diverse genus. Many species of rats are island endemics and some have become endangered due to habitat loss or competition with the brown, black or Polynesian rat.

Wild rodents, including rats, can carry many different zoonotic pathogens, such as *Leptospira*, *Toxoplasma gondii*, and *Campylobacter*. The Black Death is traditionally believed to have been caused by the micro-organism *Yersinia pestis*, carried by the tropical rat flea (*Xenopsylla cheopis*) which preyed on black rats living in European cities during the epidemic outbreaks of the Middle Ages; these rats were used as transport hosts. Another zoonotic disease linked to the rat is the foot-and-mouth disease.

A rat in a suburb of Vancouver

The average lifespan of any given rat depends on which species is being discussed, but many only live about a year due to predation.

The black and brown rats diverged from other Old World rats during the beginning of the Pleistocene in the forests of Asia.

## Rat Tails

The characteristic long tail of most rodents is a feature that has been extensively studied in various rat species models, which subsequently suggest three primary functions of this structure: thermoregulation, minor proprioception, and a nocifensive-mediated degloving response. Rodent tails—particularly in rat models—have been implicated with a thermoregulation function that follows from its anatomical construction. This particular tail morphology is evident across the family Muridae (in contrast to the bushier tails of the squirrel family, Sciuridae). The tail is hairless and thin-skinned, but highly vascularized, thus allowing for efficient counter-current heat exchange with the environment. The high muscular and connective tissue densities of the tail, along with ample muscle attachment sites along its plentiful caudal vertebrae facilitate specific proprioceptive senses to help orient the rodent in a three dimensional environment. Lastly, murids have evolved a unique defense mechanism termed "degloving" which allows for escape from predation through the loss of the outermost integument layer on the tail. However, this mechanism is associated with multiple pathologies that have been the subject of investigation.

Coronal Cross Section of Histological Layers in Murid Tail

Murid Tail Microscopy Cross Section

Murid Tail Dissection (Lateral View)

Rattus rattus (Murid) Tail Dissected

Multiple studies have explored the thermoregulatory capacity of rodent tails by subjecting test organisms to varying levels of physical activity and quantifying heat conduction via the animals' tails. One study demonstrated a significant disparity in heat dissipation from a rat's tail relative to its abdomen. This observation was attributed to the higher proportion of vascularity in the tail, as well as its higher surface area to volume ratio, which directly relates to heat's ability to dissipate via the skin. These findings were confirmed in a separate study analyzing the relationships of heat storage and mechanical efficiency in rodents that exercise in warm environments. In this study, the tail was a focal point in measuring heat accumulation and modulation.

On the other hand, the tail's ability to function as a proprioceptive sensor/modulator has also been investigated. As aforementioned, the tail demonstrates a high degree of muscularization and subsequent innervation that ostensibly collaborate in orienting the organism. Specifically, this is accomplished by coordinated flexion and extension of tail muscles to produce slight shifts in the organism's center of mass, orientation, etc., which ultimately assists it with achieving a state of proprioceptive balance in its environment. Further mechanobiological investigations of the constituent tendons in the tail of the rat have identified multiple factors that influence how the organism navigates its environment with this structure. A particular example is that of a study in which the morphology of these tendons is explicated in detail. Namely, cell viability tests of tendons of the rat's tail demonstrate a higher proportion of living fibroblasts that produce the collagen for these fibers. As in humans, these tendons contain a high density of golgi tendon organs that help the animal assess stretching of muscle in situ and adjust accordingly by relaying the information to higher cortical areas associated with balance, proprioception, and movement.

The characteristic tail of Murids also displays a unique defense mechanism known as "degloving" in which the outer layer of the integument can be detached in order to facilitate the animal's escape from a predator. This evolutionary selective pressure has persisted despite a multitude of pathologies that can manifest upon shedding part of the tail and exposing more interior elements to the environment. Paramount among these are bacterial and viral infection, as the high density of vascular tissue within the tail becomes exposed upon avulsion or similar injury to the structure. The degloving response is a nocifensive response, meaning that it occurs when the animal is subjected to acute pain, such as when a predator snatches the organism by the tail.