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That
 is a good question. I would eat breakfast but later I would throw up
when I tried to eat lunch. The only thing we can think is my system was
very stressed with the fat and meat and the stress caused the glucose to
 go up. The doctors took me off the Keto diet so now I am just doing low
 carb and slow carbs. I was not able to eat enough to stop weight loss.

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 Genelle

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One of my doctors is looking into  Doxycycline to see how we can use it.

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Hi Daniel -

My husband has stage 4 metestatic colon cancer.  What do you
reccommend for colon cancer patients?  Chemo has stopped working and his
 kidneys are becoming threatened.  Any info would be greatly
appreciated.

Kim

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Hello Daniel -

Can you give me the contact info for the chinese supplier??

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to be 100% sure on the quality. If you have a friend (or a
friend of a friend) that is working at University or that has a small
company, they can order it for you at suppliers such as Sigma Aldrich.
You can even contact a PhD student at an University (e.g. chemestry or
biochem department) that you may not know and ask for help vs additional
 payment. Since it is about life, I would prefer to be 100% confident on
 teh quality of 3BP. But if there is no option Chinese source may also
be OK.

Regarding options next to 3BP, there are many things to say. I wouldl
 start with Cimetidine (800mg/day), Modified Citrus Pectin and
Nattokinase to stop the spread. To support the organs I would take
Astragalus, Silimaryn and Alfa Lipoic Acid (600mg/day). To inhibit
angiogenesis you can add Celecobex (400mg/day). Than to attack the
cancer cells I would add 8g/day of Curcumin to kill the CSC (like Peter
sayd as well). DCA oral form should also be considered (for dose see a
previous linke I sent on this thread or check the dca site). Artemisinin
 is clearly one to consider for colon (but for other cancers as well)
while working well with 3BP. While little known, Honokiol is a greta
element to add. It has strong anticancer mechanisms behind almost at a
same level with Curcumin. The best brand to my knowledge is Honopure.

Omeprazole 40mg/day will also help.

Quercetin is a very good one to add specifically for colon but once you start 3BP stop Quercetin.

There are many things to add but this is a list of supplements that
are easy accessible and you can start the administration today.

I hope it helps.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Genelle on Sat May 09, 2015 05:08 PM
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That
 is a good question. I would eat breakfast but later I would throw up
when I tried to eat lunch. The only thing we can think is my system was
very stressed with the fat and meat and the stress caused the glucose to
 go up. The doctors took me off the Keto diet so now I am just doing low
 carb and slow carbs. I was not able to eat enough to stop weight loss.

Quote | Reply

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Genelle on Sat May 09, 2015 05:12 PM
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One of my doctors is looking into  Doxycycline to see how we can use it.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by kcervantes on Sat May 09, 2015 09:21 PM
 Quote | Reply

Hi Daniel -

My husband has stage 4 metestatic colon cancer.  What do you
reccommend for colon cancer patients?  Chemo has stopped working and his
 kidneys are becoming threatened.  Any info would be greatly
appreciated.

Kim

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by kcervantes on Sat May 09, 2015 10:24 PM
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Hello Daniel -

Can you give me the contact info for the chinese supplier??

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Danielus on Sun May 10, 2015 05:43 AM
 Quote | Reply

Hi Kcervantes, I am sorry to hear that
about your husband. Yet, there are many ways to act in order to stop
that. 3BP is one of the major ones that I fully trust as long as the
cancer is visible on PET. Increased LDH is also a sign for high
potential of 3BP.

I will send you the contact of my chinese supplier on private. Like I
 always said, if you can I would better buy 3BP from a western supplier
in order to be 100% sure on the quality. If you have a friend (or a
friend of a friend) that is working at University or that has a small
company, they can order it for you at suppliers such as Sigma Aldrich.
You can even contact a PhD student at an University (e.g. chemestry or
biochem department) that you may not know and ask for help vs additional
 payment. Since it is about life, I would prefer to be 100% confident on
 teh quality of 3BP. But if there is no option Chinese source may also
be OK.

Regarding options next to 3BP, there are many things to say. I wouldl
 start with Cimetidine (800mg/day), Modified Citrus Pectin and
Nattokinase to stop the spread. To support the organs I would take
Astragalus, Silimaryn and Alfa Lipoic Acid (600mg/day). To inhibit
angiogenesis you can add Celecobex (400mg/day). Than to attack the
cancer cells I would add 8g/day of Curcumin to kill the CSC (like Peter
sayd as well). DCA oral form should also be considered (for dose see a
previous linke I sent on this thread or check the dca site). Artemisinin
 is clearly one to consider for colon (but for other cancers as well)
while working well with 3BP. While little known, Honokiol is a greta
element to add. It has strong anticancer mechanisms behind almost at a
same level with Curcumin. The best brand to my knowledge is Honopure.

Omeprazole 40mg/day will also help.

Quercetin is a very good one to add specifically for colon but once you start 3BP stop Quercetin.

There are many things to add but this is a list of supplements that
are easy accessible and you can start the administration today.

I hope it helps.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by kcervantes on Sun May 10, 2015 12:04 PM
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Daniel -

Thank you sooo much for your insight! Would a pharmacist be able to
order the 3BP?  His sister is a pharmacist.  Also, what is the
reccommended dosage?

Funny, I just bought Cimetidine 2 days ago and started him on it :)  I will add the other items you mentioned asap.  Thank you!!

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Sun May 10, 2015 12:59 PM
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In terms of a protocol for the 3-BP, consider the melanoma patient:

Chin J Cancer. 2014 Jul;33(7):356-64. doi: 10.5732/cjc.013.10111. Epub 2014 Mar 14.
Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study.

It really seems that following a similar approach would
 make quite a bit of sense. Stay with simply IV 3-BP and paracetamol,
though just gradually work up the dose of 3-BP and feel comfortable with
 the downward trend of LDH. This treatment seems to have more horsepower
 by itself without having to add much on top.

The melanoma patient was ultimately more at risk from
the side effects of 3-BP treatment (i.e. TLS) than the cancer itself
(The doctors noted that at the last labs, the patient had been
metabolically cured of cancer). Additions could always included later on
 (perhaps fasting (ketogenic), butyrate ...).

It is not entirely clear to me whether kidney mets would pose any specific concerns.

On this thread, little discussion has been directed at
the question of targetting cancer in the GI tract. Oral 3-BP might be
one option, though it might be really effective to find some sort of
direct delivery method.

For example, Pillcam with a therapeutic payload. I have
 often imagined what the result of a Pillcam, with a theraputic payload
(e.g. 3-BP) and a balloon might accomplish. If a balloon (or balloons)
could be inflated right around a GI tumor, then the entire tumor could
be dosed. A 10 mg dose of 3-BP so applied might simply vaporize a tumor (
 A 10 mg dose would be way more than would be needed). Alternatively, a
target specific GI target pill might be considered.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by Jcancom on Sun May 10, 2015 04:45 PM
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What is the feeling on the thread regarding whether we should now really be thinking beyond straight 3-BP?

Fro example, Prescience Labs the company preparing to start a 3-BP phase 1 trial recently published a modified version of 3-BP:

Clin Cancer Res. 2014 Dec 15;20(24):6406-17. doi: 10.1158/1078-0432.CCR-14-1271. Epub 2014 Oct 17.

Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer.

As we have noted previously on this thread, the methodology used to make this modified version of 3-BP seemed simple.
Microencapsulation of 3-BrPA and nuclear magnetic resonance spectroscopy

"Encapsulation of 3-BrPA in β-CD was achieved by portionwise addition
 of 3-BrPA (166 mg, 1 mmol/L) to a stirring solution of β-CD (1,836 mg
in 30 mL DI water). The resulting solution was sonicated for 1 hour at
room temperature and then shaken overnight at 25°C, flash frozen, and
lyophilized. Encapsulation was confirmed by1H-NMR experiments performed
at 400 MHz on a Bruker Avance spectrometer."

What stir, sonicate, shake, freeze and lyophilize? That does not appear overly complex.

"The main finding of this study is that systemically delivered β-CD–3-BrPA achieved strong antitumoral effects *in vivo* while causing much less toxicity in therapeutic doses when compared with the free drug."

Staying with the known treatment protocol (3-BP + paractamol) might
be the best bet. However, if given carefully, encapsulation could amp up
 the response.

MD Anderson has developed what they call a third generation glycolysis inhibitor, 3-BrOP (Glycolysin).

http://www.cancercuremedicine.com/news-md-anderson-3-brop-or

3-bromo-2-oxopropionate-1-propyl ester (3-BrOP)

http://www.freepatentsonline.com/y2006/0058383.html

"The inventors show that Glycolycin and its derivatives/analogs have
superior pharmaceutical properties compared to other glycolytic
inhibitors, and is able to effectively block glycolysis and cause a
severe depletion of the cellular ATP pool and massive cell death,
especially in cancer cells with increased dependency on glycolysis in a
hypoxic environment or when mitochondrial respiration is defective."

Interestingly, page 3 of the pdf below appears to give the chemical method necessary to synthesize 3BrOP.

http://www.freepatentsonline.com/20060058383.pdf

The patent below claims that the reason 3-BP has not went mainstream
is the side effects caused by it. Interestingly, it is claimed that:

"Subsequent doses of 2000 mg twice a day of liposomal reduced
glutathione are administered daily for 7 days following the
administration of 3BP to minimize the effects of tumorlysis debris known
 as tumorlysis syndrome "

http://www.google.com/patents/US20130177630

Mito-3-BP was very startlingly effective.

Chem Sci. 2015 Mar;6(3):1832-1845.
The energy blocker inside the power house: Mitochondria targeted delivery of 3-bromopyruvate.

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by james-peters on Sun May 10, 2015 05:23 PM
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Glutamine Addiction: A New Therapeutic Target in Cancer http://www.ncbi.nlm.nih.gov/pubmed/9349841 http://www.ncbi.nlm.nih.gov/pubmed/7954430 http://www.nature.com/cr/journal/v22/n3/full/cr20125a.html http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917518/

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### RE: Anyone used 3bp (3-bromopyruvate)?

 by james-peters on Sun May 10, 2015 05:24 PM
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Sadly
 there isn't much data on it. It seems it reduces glutamine levels in
the body and can have an effect on glucose levels too. It may also
effect certain pathways as well

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