Chapter 104: Proliferate And Disseminate

*Much like birds and bats, dragons have an aggressively active immune system in comparison to humans, and for much the same reasons.  Simply put, for a flying animal, an inflammatory response in the face of an infection is often a death sentence, so there is significant selective pressure for immune systems which can deal with an infectious agent quickly.  In the case of draconic immune systems, this goes one step further, as an unchecked infection of the dragon's hydrocarbon organ system can have literally explosive results.*

*As such, while there* are *diseases that can affect dragons—especially ones that target the dragon's symbiotic bacteria—on the whole, a typical dragon's immune system resembles a military base swarming with constant armed patrols and barriers of razor-tipped wire.  A disease attempting to stage an infection of such a system needs to be extremely effective at intrusion, starting with thwarting the symbiotic bacteria in the salivary glands that are the immune system's first line of defense.  These bacteria not only help dragons create the biofilm mucuses that aid with fire resistance in the otherwise vulnerable soft tissues of their mouths and throats, they are primed to help their host with fighting off any microscopic invaders who attempt to get a toehold in the tissues of the mouth and gut, as the bacteria secrete a variety of antibiotics, antivirals and antitoxins—this last being significantly important in breeds whose breath can have toxic byproducts—all of which are refined by selective pressures on the symbiotic bacteria for maximum efficaciousness.*

*That being said, there is still a range within the greater dragon species in terms of immunological effectiveness.  If a typical dragon's immunological response is akin to a military base on high alert, then those dragons whose diets expose them to biological hazards up the ante, to being more akin to a forward artillery base with active minefields and with gunnery crews in possession of itchy trigger fingers.  The saliva of many Boulder-class dragons are rich in antitoxins, including ones that can encapsulate elements such as arsenic, rendering them relatively harmless and ready for expulsion in the dragon's fecal waste (although this is not a universal defense, as the radiological poisonings from the ingestions of radioactive materials and the cancers caused by the ingestion of asbestos both demonstrate). Meanwhile, Buffalords, the premier example of a draconic immune system taken to extremes, consider botulism to be a spice in the vein of how humans consider mint or caffeine, raw pufferfish is seen as a tasty snack, and cyanide is a treat.*

*—An Introduction To Dragon Biology, 17th Edition, Oxford University Press, 1793*

## Major Events

* The Healers officially conclude they are suffering a plague. They begin preparing measures for dealing with the surging cases.
* Valka contracts the hundred-days cough.
* Ruffnut tells Hiccup about the curative properties of Buffalords.

## Trivia

*Hwigi*, the game Drago and the Kagan are playing, is better known to us as *Go*.

*Al'ufiun*, the seed pods Sheepwits got from the Caliphate, are poppies, best known as the source of *opium*.

## Characters

### Humans

* Drago Bludvist
* Kagan Berk Olcayto-oğlu, the Bay-ča of the Yavdı-Erdim
* Ruffnut Thicknutsdóttir
* Olaf Magnusson
* Nanna clan Hofferson
* Sorcha clan Hofferson
* Gothi Hiccupsdóttir
* Sheepwits clan Ingerman (first appearance)
* Segna Magnusdóttir
* Magnus the Good
* Thicknut Hardnutsson
* Wulfhild of Norway
* Father Dúnchad
* Gytha Godwinsdóttir
* Fishswill clan Ingerman
* Hiccup clan Haddock
* Gobber the Belch
* Fishwings clan Ingerman
* Nittai ben Bethuel haLevi (first appearance)

### Dragons

* Brand
* Inkpot
* Toothless

## Analysis

### Epigraph Tie-In

* The epigraph discusses the dragon immune system and specifically mentions Buffalords as the premier example. The chapter shows the healers wishing they had Buffalords on hand as their immune system makes their saliva the best available cure for the hundred-day cough.