Skin

The skin is the largest organ of the body. In humans, it accounts for about 12 to 15 percent of total body weight and covers 1.5-2m2 of surface area.

The human skin (integument) is composed of at least two major layers of tissue: the epidermis and dermis.

* The epidermis is the outermost layer, providing the initial barrier to the external environment. It is separated from the dermis by the basement membrane. The epidermis contains melanocytes and gives color to the skin. The deepest layer of epidermis also contains nerve endings.
* The deepest layer, the dermis comprises two sections, the papillary and reticular layers, and contains connective tissues, vessels, glands, follicles, hair roots, sensory nerve endings, and muscular tissue.

Beneath this, the hypodermis, is primarily made up of adipose tissue. Substantial collagen bundles anchor the dermis to the hypodermis in a way that permits most areas of the skin to move freely over the deeper tissue layers.

## Epidermis

Main articles: Epidermis (skin)

The epidermis is the top layer of skin made up of epithelial cells. It does not contain blood vessels. Its main functions are protection, absorption of nutrients, and homeostasis.

In structure, it consists of a keratinized stratified squamous epithelium. The major cell of the epidermis is the keratinocyte, which produces keratin, a fibrous protein that aids in skin protection. Keratin is also a waterproofing protein. Millions of dead keratinocytes rub off daily. The majority of the skin on the body is keratinized. The only skin on the body that is non-keratinized is the lining of mucous membranes, such as the inside of the mouth. Non-keratinized cells allow water to "stay" atop the structure.

The protein keratin stiffens epidermal tissue to form fingernails. Nails grow from a thin area called the nail matrix at an average of 1 mm per week. The lunula is the crescent-shape area at the base of the nail, lighter in color as it mixes with the matrix cells. Also, the stratum corneum is the top part of the epidermis.

### Layers

The epidermis is composed of 4 or 5 layers, depending on the region of skin being considered. Those layers in descending order are:

* cornified layer (*stratum corneum*)

Composed of 10 to 30 layers of polyhedral, anucleated corneocytes (final step of keratinocyte differentiation), with the palms and soles having the most layers. Corneocytes contain a protein envelope (cornified envelope proteins) underneath the plasma membrane, are filled with water-retaining keratin proteins, attached together through corneodesmosomes and surrounded in the extracellular space by stacked layers of lipids. Most of the barrier functions of the epidermis localize to this layer.
* clear/translucent layer (*stratum lucidum*, only in palms and soles)

This narrow layer is found only on the palms and soles. The epidermis of these two areas is known as "thick skin" because with this extra layer, the skin has 5 epidermal layers instead of 4.
* granular layer (*stratum granulosum*)

Keratinocytes lose their nuclei and their cytoplasm appears granular. Lipids, contained into those keratinocytes within lamellar bodies, are released into the extracellular space through exocytosis to form a lipid barrier. Those polar lipids are then converted into non-polar lipids and arranged parallel to the cell surface. For example glycosphingolipids become ceramides and phospholipids become free fatty acids.
* spinous layer (*stratum spinosum*)

Keratinocytes become connected through desmosomes and start produce lamellar bodies, from within the Golgi, enriched in polar lipids, glycosphingolipids, free sterols, phospholipids and catabolic enzymes. Langerhans cells, immunologically active cells, are located in the middle of this layer.
* basal/germinal layer (*stratum basale/germinativum*).

Composed mainly of proliferating and non-proliferating keratinocytes, attached to the basement membrane by hemidesmosomes. Melanocytes are present, connected to numerous keratinocytes in this and other strata through dendrites. Merkel cells are also found in the stratum basale with large numbers in touch-sensitive sites such as the fingertips and lips. They are closely associated with cutaneous nerves and seem to be involved in light touch sensation.
The Malpighian layer (*stratum malpighi*) is both the stratum basale and stratum spinosum.

The epidermis is separated from the dermis, its underlying tissue, by a basement membrane.

## Dermis

Main articles: Dermis
The dermis is the middle layer of skin, composed of dense irregular connective tissue and areolar connective tissue such as a collagen with elastin arranged in a diffusely bundled and woven pattern. The dermis has two layers. One is the papillary layer which is the superficial layer and consists of the areolar connective tissue. The other is the reticular layer which is the deep layer of the dermis and consists of the dense irregular connective tissue. These layers serve to give elasticity to the integument, allowing stretching and conferring flexibility, while also resisting distortions, wrinkling, and sagging. The dermal layer provides a site for the endings of blood vessels and nerves. Many chromatophores are also stored in this layer, as are the bases of integumental structures such as hair, feathers, and glands.