Voice Cast

* April Winchell - Clerk (s1e1), Nun (s1e5), Sister Incontinential (s1e1), Teacher (s1e5), Veronica (s1e13), Martha (s2e6), Fat Woman (s3e2), Opera Lady (s4e3), Elsie (s4e8), Angela (s4e9), Geraldine (s5e4), Heather, (s5e8), Gloria (s5e13), The Queen (s6e7)
* B.J. Ward - Cameron Gentry, Sister Illegitimata (s1e3), Tabitha Soren (s1e5), Cilla (s2e3), Jill (s3e2)
* Bernadette Peters - Elsa (s11e2)
* Beyonce - Kelly (s13e4)
* Bill Farmer - Frank (s10e1)
* Billy Crystal - Freddy (s10e9)
* Cathy Cavadini - Claire (s6e2), Ash (s7e4), Bikini Girl (s11e1)
* Chris Barnes - Dispatcher (s1e4), Thug (s1e4)
* Christina Aguilera - Lucy (s14e1)
* Dakota Fanning - Emma Leigh (s8e3)
* Dan Castellaneta - Chad (s7e13)
* Dana Gould - John (s4e8), Josh (s4e15)
* David Doyle - Vet (s1e2)
* David Odgen Stiers - Chuck (s3e11)
* Debi Derryberry - Amanda Gentry (s1e3, s1e12, s2e3), Lilly (s3e1), John Fun Junior
* Donny Osmond - Paolo (s10e4)
* Dorian Harewood - Don Kling (s1e2)
* Elizabeth Daily - Tracy Dawn (s1e7), Elly (s1e11), Kate (s1e13)
* Garry Marshall - George (s9e11)
* Greg Antonacci - Huge Man (s1e1), Mr. Holmes (s3e3)
* Greg Cipes - Andy (s12e3)
* Idina Menzel - Jennifer (s5e3), Celia (s6e4)
* Jaleel White - Wayne (s1e11), Ernie (s2e4), Gilbert (s2e5)
* Jeff Bennett - Elton (s7e6)
* Jennifer Hale - Kim (s15e8)
* Jennifer Tilly - Mary Jane (s9e2)
* Jess Harnell - Mr. Watson (s5e7), Randall (s7e1), Richard (s7e11), Luther (s8e1), Oliver (s9e1)
* Jessica Simpson - Wifey (s8e10)
* Jim Cummings - Bill (s2e1), Roger Smith (S6e12), Deven (s9e2) Michael (s11e11)
* Joan Cusack - Violette (s12e12)
* Jodi Benson - Sarah (s3e13), Laura (s8e1), K.T. (s11e4), Cathy (s14e5)
* John Goodman - Mason (s9e10), Wyatt (s10e3)
* Julia Duffy - Kendall (s1e3), Margaret (s4e9), Evie (s7e11), Blonde Woman (s13e13)
* Julie Kavner - Rosemary (s11e9)
* June Foray - Elderly Woman w/ Purse (s11e3)
* Lani Minella - Louise (s8e8)
* Lauren Tom - Mrs. Fun (s1e4, s1e12), Soon-He
* Laraine Newman - Aged Nun (s1e4), Gerti (s1e4)
* Lindsay Lohan - Madonna (s11e1)
* Liz Callaway - Katie Q (s3e12)
* Mary Jo Catlett - Mother Alderman (s1e6, s1e12)
* Moesha - Brandy (s1e4)
* Nathan Lane - Donny (s5e11), Larry (s7e10), Billy (s8e4)
* Neil Ross - Alderman's Father (s1e1, s1e12), Boy in Beard (s1e3), H.A.L. (s1e3), Policeman (s1e1)
* Nell Carter (s1e2), Diana Ross (s8e4) - Betty Smythe
* Nick Jameson - Secret Service Agent (s1e1)
* Nick Lachey - Hubby (s8e10)
* Paige O'Hara - Samantha (s4e1), Alex (s5e13), Edie (s9e12)
* Patrick Stewart - Gordon (s2e11)
* Patrick Warburton - Ryan (s9e4)
* Paul Eiding - Foreman (s1e3), Doorman (s2e13)
* Pat Carroll - Estelle (s11e11)
* Phil Proctor - Patent Agent (s1e1), Afro Boy (s4e2)
* Rihanna - Pat (s11e13)
* Rob Paulsen - Benny Fingers (s1e2), Doctor (s1e2), Policeman (s3e1), Jeff (s4e2), Jack (s6e13), Raymond (s8e10), Skater Boy (12e3), Man Who's Car Got Robbed (s12e4), Pink Guy (s12e8)
* Robbie Rist - Rocky (s1e7), Paul (s4e3), Mel (s7e2)
* Robert Picardo - Mr. Gentry, Smenge Mouthwash Guy (s1e3)
* Roger Clinton - President Clinton (s1e1)
* Rose Marie - Sister Rotonda (s1e2), Miss Ramsay (s1e12)
* Russi Taylor - Cindy (s4e5)
* Ryan Drummond - Doug (s8e1), Rob (s9e8), Cole (s11e13), Nicky (s12e12)
* Sara Ramirez - Melanie (12e3), Amaya (14e15), Amrita (s15e9)
* Scott Dreier - Tom (s4e8), James (s6e9)
* Sharon Stone - Amy (s2e3)
* Stephanie Lynn "Sugarbaby" Beard - Blue Girl (s12e8)
* Sutton Foster - Hilary (s10e3), Whitney, (s10e13)
* Tara Strong - Annie (s4e3), Kimberley (s5e1), Emma (s6e12), Hannah (s7e1), Jessica (s8e1), Rianne (s9e2), Baby (s11e13), Gianna (s12e13), Mariah (s13e9), Teenage Girl (s14e10), Anna Mae (s15e2), Tina (s15e13), Jane Fun Jr
* Tress MacNeille - Gaily (s3e5) Adele (s7e1), Michelle (s9e4), Katrina (s11e7), Jolene (s15e7)
* Teresa Ganzel - Vera (s1e5), Keane (s1e13, s2e6)
* Tim Curry - Don Kennedy (s1e3), Principal Interest (s1e7), Mr. Dawson (s1e13), Sergei (s2e7)
* Zach Braff - Dennis (s9e1), Henry (s12e3), Gareth (s14e7), Sam (s15e13)

### UK Dub

* Ade Edmondson - Jake, Freddy (s10e9)
* Emma Tate - Bobby G., John Fun Junior, Jane Fun Jr. and Simon.
* Justin Fletcher - Dennis (s9e1), Henry (s12e3), Gareth (s14e7), Sam (s15e13)
* Victoria Beckham - Amy (s2e3)