Serpula lacrymans

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 File:Serpula lacrimans.jpg
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***Serpula lacrymans*** is one of the fungi that cause damage to timber referred to as dry rot. It is a basidiomycete in the order Boletales.

## Taxonomy

The species was first described under the name *Boletus lacrymans* by Franz Xavier von Wulfen in 1781. It was transferred to the genus *Serpula* by Petter Karsten in 1884.

The specific epithet is derived from the Latin words *serpula* for "creeping" (as in a serpent) and *lacrymans*, meaning "making tears".

## Environment

*Serpula lacrymans* has a preference for temperatures of Template:Convert but can survive any temperature from Template:Convert. It is not clear how much light is needed to promote *Serpula lacrymans* growth. In terms of aeration *Serpula lacrymans* often grows near ventilation shafts which shows a preference for concentrated oxygen. A moisture content of 30 to 40 percent is its ideal level in wood to promote fruit body formation. It appears that *Serpula lacrymans* requires an environment where both inorganic and organic materials are present. The fungus uses calcium and iron ions extracted from plaster, brick, and stone to aid the breakdown of wood, which results in brown rot.

## Distribution

Although it is a common indoor biodeterioration agent, it has only been found in a few natural environments, the Himalayas, Northern California, the Czech Republic and east Asia. A recent study on the evolutionary origin and spread of this species using genetic markers (amplified fragment length polymorphisms, DNA sequences and microsatellites) on a worldwide sample of specimens suggested the existence of two main lineages, a nonaggressive lineage found in North America, and an aggressive lineage found on all continents, both in natural environments and buildings.

## Impact on structures

*Serpula lacrymans* is considered to be the most damaging destroyer of indoor wood construction materials in temperate regions.

In the United Kingdom alone, money spent by building owners rectifying damage caused by dry rot was at least 150 million pounds per annum.

## Genome

Three variants/strains of S. lacrymans have been sequenced by the Joint Genome Institute (JGI) and its collaborators, and sequence data is available via their MycoCosm portal. One genome is from Serpula lacrymans S7.9 (v2.0). The genome assembly is 42.73 Mbp, with a predicted number of 12789 genes. The second genome is from Serpula lacrymans S7.3 (v2.0). The genome assembly is 47 Mbp, with a predicted number of 14495 genes. The third genome is from Serpula lacrymans var shastensis SHA21-2 (v1.0). The genome assembly is 45.98 Mbp, with a predicted number of 13805 genes.

## Natural products genes

*S. lacrymans'* genome encodes six annotated polyketide synthases (PKS1-PKS6), 15 nonribosomal peptide synthetases (NPS1-NPS4, NPS7, NPS13-NPS15, NPS17, and NPS18), and two hybrids thereof (NPS6, NPS8, and NPS16). Additionally, the genome encodes for various putative adenylate-forming reductases (NPS5, NPS9-NPS12) (Eastwood et al., 2011). *NPS3* was overexpressed in E. coli and characterized as an atromentin/quinone synthetase that catalyzes the formation of atromentin, similar to GreA; InvA1,2 and 5; and AtrA from Suillus grevillei, Tapinella panuoides, Paxillus involutus, respectively. *NPS3* and its adjacent clustered aminotransferase gene (*AMT1*) were also found to be up-regulated during co-incubation with bacteria (Tauber et al., 2016).

## Natural products

The genus *Serpula*, including *S. lacrymans* and *S. himantoides*, is known to produce three classes of chemical compounds: pulvinic acid-type family, himanimides, and polyine acids. Within the pulvinic acid-type family, atromentin-derived compounds include variegatic acid, xerocomic acid, isoxerocomic acid, atromentic acid, variegatorubin, xerocomorubin, and other variants of these pigments. Pulvinic acid-type family pigments were found to be secreted during co-incubation with various bacteria.

## References

1. ↑ Cite error: Invalid `<ref>` tag; no text was provided for refs named `Jacquin1781`
2. ↑ Cite error: Invalid `<ref>` tag; no text was provided for refs named `urlMycoBank: Serpula lacrymans`
3. ↑ Cite error: Invalid `<ref>` tag; no text was provided for refs named `Douglas1997`
4. ↑ Cite error: Invalid `<ref>` tag; no text was provided for refs named `urlGrieve`
5. ↑ Cite error: Invalid `<ref>` tag; no text was provided for refs named `Palfreyman2001`
6. ↑ Cite error: Invalid `<ref>` tag; no text was provided for refs named `Bagchee1954`
7. ↑ Cite error: Invalid `<ref>` tag; no text was provided for refs named `White2001`
8. ↑ Cite error: Invalid `<ref>` tag; no text was provided for refs named `Cooke1955`
9. ↑ Cite error: Invalid `<ref>` tag; no text was provided for refs named `Harmsen1960`
10. ↑ Cite error: Invalid `<ref>` tag; no text was provided for refs named `Kotlaba1992`
11. ↑ Cite error: Invalid `<ref>` tag; no text was provided for refs named `Kauserud2004`
12. ↑ Cite error: Invalid `<ref>` tag; no text was provided for refs named `Kauserud2007`
13. ↑ 13.0 13.1 Cite error: Invalid `<ref>` tag; no text was provided for refs named `Jennings1991`
14. ↑ Cite error: Invalid `<ref>` tag; no text was provided for refs named `Schmidt2006`
15. ↑ Hearn et al., 1973Template:Full citation needed
16. ↑ Gill and Steglich, 1987Template:Full citation needed
17. ↑ Aqueveque et al., 2001Template:Full citation needed
18. ↑ Eastwood et al., 2011Template:Full citation needed
19. ↑ Gill and Steglich, 1987.Template:Full citation needed
20. ↑ Tauber et al., 2016Template:Full citation needed

## External links

* Template:IndexFungorum

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