Panic Button

**Panic Button** is a trinket added in *The Binding of Isaac: Repentance*.

## Effects

* Activates Isaac's active item just before damage would be taken.
	+ This still uses the item's charges so if the item is not charged, the trinket will do nothing.
	+ Single-use items will be consumed.

## Notes

* Panic Button will attempt to use the item 2-3 times per tick as damage is incoming. This may cause some unlimited use items to trigger multiple times before one damage instance.
* Some items will be activated after respawning if Isaac is killed by the incoming damage, including  and .
* Taking damage from explosions, enemy creep, spikes and spike rocks, Spiked Chest and Mimic Chest, some attack from above (for example, the stomp attacks from Mom and Satan), Whipper and their variants, brimstone lasers (including angel lasers), electric lasers, self-damage items, Devil Beggar, Hell Game, Blood Donation Machine, and Confessional will not trigger the effect.
* Does not activate items in a consumable slot (such as  Tainted Bethany's  or dice items granted by ).
* Will activate when touching Dark Esau while playing as  Tainted Jacob, despite Dark Esau not technically dealing damage.
	+ This effect still occurs even whilst he is chained by , when he deals no contact damage.

## Interactions

* Any self-damaging item: Self-damage occurs before enemy damage, making it almost impossible to lose Devil/Angel Room chances.
	+ For self-damaging items that deals only half a heart damage (such as ), before chapter 4, it will also reduce enemy damage to half a heart, similarly to .
* with  / : Activate their respective effects without consuming it.
* with  /  /  / : Activate their respective effects without consuming it.
* : Triggers the effect on hit, at the cost of a full-heart of damage on the first hit and half-heart damage on subsequent hits in the same room.
* : Activates the item, giving Isaac the shield effect for 10 seconds.
* : Even though the neutral spiders spawned by the item can't possibly hurt Isaac, the trinket still activates when contact is made with them.
* / : Isaac farts before being hit, knocking back enemies and projectiles.
* : Unlike many other items on this list, Dark Arts can be used to negate damage more than once per room, making it an excellent defensive item to use with Panic Button. Note that this does **not** work while playing as Tainted Judas.
* : Activates the item and gives Isaac invincibility frames before being hit, making it work similarly to  every two rooms. If combined with  or , works every room, just like Holy Mantle. If combined with   and  it will make Isaac almost invincible.
* : If consumed with , every time Isaac is hit, if it's charged, he is sent back to the previous room without taking damage.
* : Does *not* stop the trinket from activating, making Isaac still take damage from items such as , while bypassing Holy Mantle's shield.
	+ The Lost can die this way should he carry self damaging items at the time of the hit.
* : Makes Isaac immune to contact and tear damage while moving.
* : Upon getting hit, activates the IV Bag instead, causing self-damage and producing money.
* : Causes a highly-damaging explosion to occur every time Isaac is hit, similarly to .
* : Gives invulnerability and +0.28 speed for six seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies.
* : Isaac gains a damage boost every time he's hit, acting similarly to , at the cost of a full-heart of damage on the first hit and half-heart damage on subsequent hits in the same room.
* : Has a chance to spawn additional wheels upon taking damage that last only for the current room. This is most likely a bug.
* : Isaac will teleport before damage is taken, making him much harder to hit.
* Tainted Forgotten: Triggers his active item whenever the body touches something that would damage The Soul, regardless of damage taken.
* : As long as Suplex! is fully charged, Panic Button automatically triggers when about to take damage, avoiding the damage and potentially grabbing an enemy in the process. Allows Isaac to grab an enemy by simply walking into them, provided the item is charged.
* : Automatically blocks any incoming shots, but the push is not strong enough to prevent contact damage.
* : Turns the character into a Pac-Man-like creature for 6.5 seconds and provides invulnerability, inflicts fear on all enemies, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies.
* : Gives invulnerability and +0.28 speed for six seconds, but removes the ability to shoot tears while the effect is active.
* : Since the effect is triggered before taking damage, Panic Button will waste the charge with no benefit unless Isaac is already missing Red health.