Cambion Conception

### Collection Grid

*(page 4, column 7, row 3)**(page 4, column 7, row 3)**(page 4, column 8, row 3)*

### Unlock Method

 Defeat ??? as  Lilith

**Cambion Conception** is an unlockable passive item added in *The Binding of Isaac: Afterbirth*.

## Effects

* Upon taking damage a certain number of times, Isaac gains a permanent demonic familiar. Possible familiars include:
* The first and second familiars will each spawn after taking damage 15 times. The third and fourth familiars will each spawn after taking damage 30 more times. No further familiars will spawn. As a result, after taking damage 90 times, four out of eight possible familiars will have spawned.
* Isaac will look progressively more pregnant as he takes damage.
* Familiars spawned this way do not count towards transformations nor the collection page.

## Notes

* Lilith starts with this item by default, even if it hasn't been unlocked. Lilith can get a second  through this.
* Only one of each type of familiar can be spawned.
* Familiars that have yet to be unlocked can spawn,  with the exception of  and , which must be unlocked before they can spawn through Cambion Conception.
* Only actually getting damage counts towards the payout. For example, negating damage with the  will not count. Blood donation machine count as damage taken.
* Familiars spawned by the item do not affect item pools, so multiple copies of one familiar can be obtained. For example, a second Incubus can be purchased after Cambion Conception spawns one.
* If a familiar obtained is a copy of another one already obtained, using  will only clone one of that familiar.
* If this item is removed in anyway (such as with a ), the familiars from Cambion Conception will be removed upon updating familiars, including picking up items that don't add familiars but update its cache, such as .
	+ If the item is re-obtained after being removed (e.g. by dropping the item as  Tainted Isaac), the damage counter and familiar limit will be reset, allowing Isaac to obtain all eight familiars with only one Cambion Conception. If the familiars were removed, all will return once familiars are updated.

## Synergies

* : Dull Razor counts towards the payout despite not removing health from Isaac.
* : By intentionally taking damage with something like a fire and grabbing the half-red hearts, Isaac can easily generate powerful familiars for free.
* : By intentionally taking damage with something like a fire to half a red heart a soul heart will be generated. Leaving the room and taking damage again will continuously allow damage to be taken.

## Interactions

* : Makes it impossible to tell how far along the pregnancy is.
* : Having a second Cambion Conception allows the player to get the eight familiars, but cannot give an already obtained familiar.

## Trivia

* This item is the demonic counterpart to .
* In mythology, a cambion is the offspring of a human and an incubus or succubus.
* During the development of Afterbirth, Edmund McMillen asked on Twitter what the opposite of  would be called. 27 people replied with suggestions, but none of them were used.

## References

1. ↑ https://twitter.com/edmundmcmillen/status/561422400269471744