Datasets:

rag-datasets

/

rag-mini-bioasq

like 19

Follow

RAG Datasets 12

Are synonymous sites in primates and rodents functionally constrained?

No. Synonymous sites in primates exhibited evidence for higher selective constraint that those in rodents. In primates up to 24% of synonymous sites could be under purifying selection, while in rodents synonymous sites evolved neutrally.

[26563252]

Which animal bite can cause Capnocytophaga canimorsus infection?

Capnocytophaga canimorsus infection is typically associated with dog bites, especially in asplenic or immunocompromised patients, and typically manifest as sepsis and/or bacteremia.

[25024773, 25445385, 30776586, 27837588, 28831382, 26947740, 18366884, 11269682, 20407357, 29593919, 23267527, 2915017, 31857872, 16904274, 24997586, 32197716, 22293076, 12613462, 18926295, 27364692, 7588825, 10352221, 29523423, 25828064, 26608484, 17205476, 26608488, 30706413, 21242095, 19201139, 15201655, 31742204]

What is the function of lysozyme?

Lysozymes are an ancient group of antimicrobial enzymes of the innate immune system. Lysozyme activity is a marker of Paneth cell function.

[31989035, 31790908, 32730854]

Explain amniotic band syndrome.

Amniotic band syndrome (ABS) is a rare congenital disease with variable manifestations ranging from simple constriction rings at the extremities to major defects such as exencephaly.

[31528593, 8851988, 3292449, 23248551, 29634607, 29653043, 17560504, 29876159, 14607048, 9444044, 32335054, 31516628, 21837919, 7124837, 9804264, 21080173, 15067893, 26159096, 8360442, 24779260]

Which are the main advantages of kallisto against similar methodologies?

Kallisto is a pseudo-alignment algorithm, which is a way of quantifying RNA-sequencing. It's used in RNA-seq because it's much faster and more efficient than other methodologies.

[28484260, 28868134, 30168903, 28361706, 28096075, 31357172, 27043002]

What methodology does the HercepTest use?

The HercepTest is immunohistochemistry based.

[32256703]

Which R/Bioconductor package has been developed for gene expression signature searching?

SignatureSearch is an R/Bioconductor package that integrates a suite of existing and novel algorithms into an analysis environment for gene expression signature (ESE) searching combined with functional enrichment analysis (FEA) and visualization methods to facilitate the interpretation of the search results.

[33068417]

Which molecule is targeted by Upadacitinib?

Upadacitinib is a Janus kinase 1 inhibitor developed for treatment of moderate to severe rheumatoid arthritis.

[31317509, 32648334, 29076110, 31130260, 33129109, 30633369, 31378969, 30394138, 32044319, 29688617, 31786154, 31327403, 29672874, 32530345, 31867699, 31654328, 29908669, 29908670, 31287230, 30886973, 30725185, 28765121, 30973649, 28503781, 30500075, 28762476, 31448433, 32776305, 31692920, 31781755, 31401212]

What is known about natriuretic peptide receptor A?

Atrial natriuretic peptide (ANP) and its natriuretic peptide receptors A (NPR-A) and C (NPR-C) are involved in the regulation of physiological and pathophysiological process of blood pressure. The natriuretic peptide receptor A (NPRA), also known as NPR1 or guanylyl cyclase A, binds ANP and BNP to initiate transmembrane signal transduction by elevating the intracellular levels of cyclic guanosine monophosphate.

[32433050, 33200806]

What is the mode of action of dexamethasone?

Glucocorticoids like Dexamethasone have a number of modes of action. While these drugs are used to reduce inflammation, Dexamethasone can also induce apoptosis thru initiation of autophagy, activate glucocorticoid receptors in the treatment of uveitic edema, alter gene expression in allergic asthma prevent tachycardia-induced ionic remodeling by reduction of atrial sodium current I(Na), increase gut permeability and suppress inflammation. in addition, Dexamethasone (Dex) can enhance BMP-2-induced osteoblast differentiation and can differentially modulated dendritic cell maturation and TREM1 signaling pathways in GM-CSF-treated and M-CSF-treated monocytes. Dexamethasone can be used for pain management

[29449600, 7503523, 32262373, 25347463, 21715273, 32133644, 14965196, 26496078, 28515280, 8523985, 30485523, 8530259, 8559285, 23511350, 9891987, 31547289, 26891836, 19390558]

What is the phenomenon described as "complex coacervation"?

Here, we demonstrate that charge-mediated phase separation, or complex coacervation, of RNAs with cationic peptides can generate simple model liquid organelles capable of reversibly compartmentalizing biomolecules. Impact of macromolecular crowding on RNA/spermine complex coacervation and oligonucleotide compartmentalization. The addition of PEG decreased both the amount of spermine required for phase separation and the coacervation temperature (TC).

[29265152, 24268195, 25565379, 18592584, 21377640, 27633928, 32033133, 31041391, 32134099, 30384692, 33230101, 26791895, 30995741, 21230139, 27161661]

Which proteins does RG-7992 target?

BFKB8488A is a bispecific antibody against FGFR1 and KLB.

[33139537]

Is there a role for TFII-I in megakaryopoiesis?

Yes. TFII-I acts as a repressor of β-globin gene transcription and is implicated in the differentiation of erythrocytes into megakaryopoiesis. Mutations in exon 2 interfere with the synthesis of the full-length isoform of TF II-I and lead to the production of a shortened isoform, TFII, in erythroid cells. TF2-I has a role in embryonic development and differentiation of all eukaryotes but its physiological function is still unclear.

[33101065]

Which drugs are included in the VAC regiment for Ewing's sarcoma?

VAC regiment for Ewing's sarcoma includes vincristine, actinomycin, cyclophosphamide.

[15626016, 20110048, 991106, 26271204, 9053479, 31197128, 10742059, 12441260, 7029293, 2667789, 2016622, 14521810, 15613556, 11531770, 7583389, 29541566]

Is YKL-40 used as a biomarker for Alzheimer's disease?

Yes, cerebrospinal fluid (CSF) YKL-40 levels were reported to be a promising candidate biomarker of glial inflammation in Alzheimer's disease (AD).

[31794792, 32045356, 31668967]

On what chromosome is the gene for "SILVER" coat color found for the domestic cat?

Linkage mapping defined a genomic region for SILVER as a 3.3-Mb region, (95.87-99.21 Mb) on chromosome D2 in the domestic cat.

[19398491]

Which lncRNAs are induced by heatshock?

Malat1, papas, long noncoding rnas, circrna, neat1, and mirna are induced by heat shock.

[26634309, 26142536, 22976942, 27257073, 30305397, 27518140, 24002685, 29228702]

What is the prevalence of poor metabolizers of CYP2C19 among Southern Asians compared to East Asians?

Southeast Asians exhibit a higher prevalence of CYP2C19-poor metabolisers compared with Caucasians and East Asians.

[31846723]

Which R/Bioconductor package has been developed for network-based differential expression analysis?

INDEED is an R/Bioconductor package for network based differential expression analysis. INDEED allows users to construct a sparse network based on partial correlation, and to identify biomolecules that have significant changes both at individual expression and pairwise interaction levels.

[31179159]

Can propofol cause green urine?

Yes, propofol can cause green discoloration of urine. It is a rare and benign condition, which occurs when clearance of propofol exceeds the hepatic and extrahepatic elimination.

[30809505, 23326690, 14738690, 27871556, 25394533, 26673613, 30625744, 28733841, 10999506, 21623455, 31094132, 28396792, 17484185, 21083675, 25332856, 27900925, 28543518, 7851359]

Are Gram positive bacteria able to release extracellular vesicles?

Yes, Gram-negative and Gram-positive bacteria release a variety of membrane vesicles through different formation routes.

[31675472, 31776460, 31988111]

Describe a cytokine release syndrome.

The major factor responsible for acute respiratory distress syndrome is the so-called "cytokine storm," which is an aberrant response from the host immune system that induces an exaggerated release of proinflammatory cytokines/chemokines.

[32983172, 32474885, 18382853, 32776808, 32678378, 32446778, 17471824, 32166291, 31755797, 33262810]

Which genes are the main markers of primitive Endoderm (prEN) formation?

The genes involved in primitive endoderm (prEN) formation are fgf4, lrp2, gata4, pdgfra, p dgfrα, gATA6, nanog, pDgfralpha, egam1 and dab2.

[9895328, 24752320, 1455234, 22914948, 27060901, 22608553, 24835466, 18725515, 7772748, 18816845, 23193166, 24504341, 18083160, 20925113, 22607194, 22172669]

What are the EMA and FDA recommendations regarding pharmacogenetic testing for abacavir?

Abacavir HSRs are highly associated with the major histocompatibility complex class I. Large studies established the effectiveness of prospective HLA-B*57:01 screening to prevent HSRs to abacavir. Accordingly to these results the abacavir label has been modified: the European Medicines Agency (EMA) and the FDA recommend/suggested that the administration of abacavir must be preceded by a specific genotyping test. The HLA locus is extremely polymorphic, exhibiting many closely related alleles, making it difficult to discriminate HLA-B*57:01 from other related alleles, and a number of different molecular techniques have been developed recently to detect the presence of HLA-B*57:01.

[23204921]

Describe PWMScan

PWMScan is used to scan a position weight matrix (PWM) against a genome or, in general, a large set of DNA sequences. The PWM is the most commonly used mathematical model to describe the DNA binding specificity of a transcription factor (TF).

[29514181]

Is vocimagene amiretrorepvec effective for glioblastoma?

No. Treatment with vocimagene amiretrorepvec did not improve survival of glioblastoma patients.

[33119048, 32816892]

List the major royal jelly proteins in Apis mellifera.

The genome of the western honeybee (Apis mellifera) harbors nine transcribed major royal jelly protein genes (mrjp1-9) which originate from a single-copy precursor via gene duplication.

[22571915, 32042077, 24279675, 31410279]

What is BEL(Biological Expression Language) used for?

Biological Expression Language (BEL) is a novel method for the statistical extraction of causal relation relationships from large biomedical literature datasets.

[27694210, 30624649, 27554092, 26636108, 27173520, 30961584, 29048466, 26200752, 27173525, 27402677, 31603193, 23515068]

Which database contains gene expression data for yeast?

We developed the ExpressDB database for yeast RNA expression data and loaded it with approximately 17.5 million pieces of data reported by 11 studies with three different kinds of high-throughput RNA assays.

[25404128, 20025988, 24350770, 10779484, 25024351]

Which CYP gene polymorphism is a well-known predictor of efavirenz disposition?

Cytochrome P450 (CYP) CYP2B6 G516T (rs3745274) is a well-known predictor of efavirenz disposition.

[31514420, 31628422]

What is the role of the IRE1a-XBP1 pathway?

The IRE1a-XBP1 pathway is a conserved adaptive mediator of the unfolded protein response, playing an important role in the regulation of cell differentiation.

[30355343]

Can Panitumumab cause trichomegaly?

Yes. Panitumumab is EGFR inhibitor that is associated with eyelash trichomegaly.

[23010833, 33028137, 20726623]

List proteins that are contained in atherosclerotic plaques?

extracellular matrix proteins biglycan Lumican Apolipoprotein A-I

[29907817, 31382484, 29129081, 32012358]

List characteristics of Developmental and Epileptic Encephalopathies (DEEs).

yes, developmental and epileptic encephalopathies (dees) are a group of severe, early onset epilepsies characterized by refractory seizures, developmental delay or regression associated with ongoing epileptic activity, and generally poor prognosis.

[30656450, 29090338, 30166628, 31926053, 31468518, 30343943, 32201576, 32139178, 32705489, 33236786, 32899411, 29100083, 31064215, 32427099, 30255934]

Which methods exist for efficient calculation of Elementary flux modes (EFMs) in genome-scale metabolic networks (GSMNs)?

EFM-Ta is a novel algorithm that uses a linear programming-based tree search and efficiently enumerates a subset of EFMs in genome-scale metabolic networks (GSMNs). The stand-alone software TreeEFM is implemented in C++ and interacts with the open-source linear solver COIN-OR Linear program Solver (CLP).

[25380956, 32348455]

What is the mechanism of action of vosoritide?

Vosoritide is a biologic analogue of C-type natriuretic peptide, a potent stimulator of endochondral ossification.

[31269546, 31235532]

What is the "flight-or-fight response"?

This is also known as " flight-or- fight response" and is defined as an individual's response to a stimulus such as stress, that includes loss of sleep, anxiety, shortness of breath, muscle and joint pain.

[24704321, 25905810, 19834455, 17615391]

How is Burke-Fahn-Marsden Dystonia scale used?

Burck-Fahn-Marsden Dystonia scale (BBS) is a simple, reliable, and valid measure of disease severity in patients with dystonia.

[23549056, 17608320, 15264773, 32796550, 21147544, 28661018, 21491490, 32252836, 22258088, 17274034, 32079672, 23408442, 26616635, 33084096, 31817799, 24461258, 21692107, 32386250, 31207377, 27770067, 20207700, 32731476, 31954905, 20697054, 32441447, 30838251, 28548593, 33159411, 27567612]

Is methotrexate used for the treatment of Rheumatoid Arthritis (RA)?

Yes, methotrexate is effective for the treatment of Rheumatoid Arthritis. MTX can be administered in combination with other chemotherapeutic agents or as mono-therapy. Response rate to MTX is more than 90%. MTX therapy is associated with improved survival of RA patients.

[7939730, 23970326, 26474779, 15305245, 24219041, 8646434, 3913772, 30081197, 3913774, 28081972, 3741499, 29441860, 22870474, 26459854, 3891280, 24399184, 21044436, 7482069, 31866617, 8535646, 2080488, 32876784, 9402864, 2388211, 27708921, 32066940, 14963199]

What methodology does the FoundationOne CDx test use?

FoundationOne CDx is a next generation sequencing (NGS) based test.

[32393302]

Which R/bioconductor package exists for discovery of intergenic transcripts?

To increase the power of transcript discovery from large collection of RNA-seq data sets, a novel '1-Step' approach named pooling RNA-Seq and Assembling Models (PRAM) has been developed that build transcript models from pooled RNA- sequencing data sets. PRAM is implemented as an R/Bioconductor package.

[32958497]

What is the mechanism of action of idasanutlin?

Idasanutlin is a small-molecule inhibitor of MDM2, a negative regulator of tumor suppressor p53.

[30647052, 30700046, 33302031, 29857559, 26993060, 31734832, 33190064, 31167802, 30158012, 30536898, 29392451, 30352966, 32629830, 27353420, 26586447, 32020437, 32167393, 31289443, 30755442, 29368050, 30511219, 29768700]

Where is corticosterone synthesized?

Following a stressful event, the hypothalamus-pituitary-adrenal axis mediates the release of the stress hormone cortisol (corticosterone in rodents; CORT).

[31953122, 31972205, 30318934, 32347034, 32047871]

Where is the klotho protein primarily expressed in the body

The klotho protein is primarily expressed in the lungs, kidney, lens, cerebellum, trpc6, renal cells and the brain.

[22396165, 12362891, 22338062, 19464978, 21496980, 32052504, 32005658, 32479899, 31951006, 31928223, 9791011, 28709936, 17287345, 25466545, 26307633, 23928372, 23375286, 32438076, 31920703, 12204354, 32466632, 29053774, 33179086, 16358222, 32347987, 19184092, 15665504, 30233703, 30358003, 23838326, 23748218, 24457979]

Which particular intersex phenotype is related to steroid reductase?

Steroid reductase mutations are associated with both sex-determining and non-syndromic hypospadias

[21714467, 24383016, 8723114, 11392378, 9247984, 21893969, 25077171, 8262007, 31981690]

Is atenolol metabolized by CYP2D6?

No, atenolol is metabolized in a CYP2D6-independent manner.

[20406225]

Describe DeepTRIAGE

DeepTRIAGE (Deep learning for the TRactable Individualised Analysis of Gene Expression) is a novel deep learning architecture which uses an attention mechanism to obtain personalised biomarker scores that describe how important each gene is in predicting the cancer sub-type for each sample. DeepTRIAge simultaneously reveals heterogeneity within the luminal A biomarker score that significantly associate with tumour stage, placing all luminal samples along a continuum of severity.

[32093737]

What is Pseudomelanosis duodeni?

Pseudomelanosis duodeni is a rare incidental finding seen on endoscopy and has the characteristic appearance of flat, black-speckled pigmented mucosa that can be associated with gastrointestinal bleeding, hypertension, chronic heart failure, chronic renal failure and consumption of different drugs.

[32313471, 27701885, 10998854, 31528551, 29564071, 10532135, 3047212, 28679982, 1341423, 27785200, 9050065, 22493558, 18253910, 10958041, 3371613, 24326430, 8527967]

Is the glucocorticoid receptor a transcription factor?

Yes, The glucocorticoid receptor (GR) is a ligand-activated transcription factor that translocates to the nucleus upon hormone stimulation and distributes between the nucleoplasm and membraneless compartments named nuclear foci.

[32487073, 31776270, 31689103]

What are the five traits associated with metabolic syndrome?

Metabolic syndrome is the concurrent presentation of multiple cardiovascular risk factors, including obesity, insulin resistance, hyperglycemia, dyslipidemia and hypertension.

[25612864, 15157122, 20694148, 24260389, 12240700, 29502759, 16305067, 26956847, 32562864, 20021073, 20018034, 31637139, 26175188, 17918262, 18489847, 25104441, 14975163, 19137372]

Which gene is responsible for the Liebenberg syndrome?

Liebenberg syndrome is a genetic disease caused by heterozygous mutations or deletions of the zinc finger E-box-binding homeobox 2 (ZEB2) gene. Patients present with prominent neurological, medical, and behavioral symptoms.

[23395106, 23940102, 23587911, 32598510, 30711920, 23022097]

Which pharmacogenetic test is recommended prior to administering carbamazepine and why?

HLA-B∗15:02 is known as a biomarker for carbamazepine (CBZ) induced Steven-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) in some Asian populations. Hence United States Federal Drug Administration (USFDA) recommends HLA-B∗15:02 screening for Asian and other populations with a high prevalence of HLA-B∗15:02, prior to the administration of carbamazepine.

[27060780]

Are there sex differences in oncogenic mutational processes?

Yes. Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. There are sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes.

[32859912]

Which drugs are included in the MAID chemotherapy regimen for sarcoma?

MAID chemotherapy regimen for sarcomas include mesna, adriamycin, ifosfamide and dacarbazine.

[7672707, 2050307, 16446334, 31232921, 22179493, 2110385, 32427061, 23092789, 12478905, 30032825, 2504890, 9529020, 8951354, 32881345, 7595717, 12445253, 12829150, 10362334, 21652583, 24647783, 11300337, 18313854]

Which is the main ligand for the glucocorticoid receptor?

Glucocorticoids (GC) such as cortisol regulate multiple physiological functions, notably those involved in development, metabolism, inflammatory processes and stress, and exert their effects upon binding to the glucocorticoid receptor (GR, encoded by NR3C1 gene in humans).

[32381682, 32528419, 31995340, 32607951]

Who received the Nobel prize for development of CRISPR?

The 2020 Nobel Prize in Chemistry was awarded to CRISPR-Cas pioneers Emmanuelle Charpentier and Jennifer Doudna. Charpentier and Doudna pioneered the site-specific CRISPR gene-editing technology that has revolutionized cancer research and treatment.

[33287895, 33300275, 33201862, 33037027]

How are super enhancers defined?

Super-enhancers are defined as genomic regions spanned by highly conserved non-coding elements (HCNEs), most of which serve as regulatory inputs of one target gene in the region.

[26438538, 30169995, 25936917, 28034838, 27677335, 31533978, 30925856, 26578594, 24119843, 29861161, 32396464, 30541891, 26277449, 30078801, 30814546, 25547603, 26569311, 25394790, 30371817, 28373363, 25564661, 28991225]

Is metoprolol metabolized by CYP2D6?

Yes, metoprolol is metabolized by CYP2D6.

[14732961]

List versions of ExpansionHunter

ExpansionHunter and ExpansionHunter Denovo

[32345345, 31134279]

What are the uses of Nirsevimab?

A single injection of nirsevimab resulted in fewer medically attended RSV-associated lower respiratory tract infections and hospitalizations than placebo throughout the RSV season in healthy preterm infants.

[32726528, 32759319]

What is the proteoglycan Tsukushi?

Tsukushi (TSK), a member of the small leucine-rich repeat proteoglycan (SLRP) family, plays multifunctional roles by interacting with signaling molecules during development. In lung cancer cells, TSK is expressed more highly than the other SLRPs family members, and regulates the EMT and proliferation. Thus, TSK may be a key coordinator of multiple pathways and an important structural element in the lung cancer microenvironment. Gain- and loss-of-function analyses showed that the small leucine-rich proteoglycan, tsukushi, contributes to vitamin K2-mediated enhancement of collagen accumulation.

[18095058, 31027686, 16606623]

Does Curare function by stimulating the acetylcholine receptor?

No. Curare function does not stimulate the acetylcholine receptor.

[2713760, 4351811, 12624651, 26818254, 8355663, 21422738, 8166227, 6283380, 16083, 10934261, 6308151, 22194270, 11849819, 2479422, 25409503]

Are somatic mutations positioned towards the nuclear periphery?

lamina-associated regions, which are typically localized at the nuclear periphery, displayed higher somatic mutation frequencies than did the interlamina regions at the nuclear core. Smoking and UV-related signatures, as well as substitutions at certain motifs, were more enriched in the nuclear periphery.

[28967881, 11243810, 15494683]

Which biological drugs are EMA approved for pediatric psoriasis?

Currently there are three European Medicines Agency (EMA)-approved biological treatment options for pediatric psoriasis: etanercept, ustekinumab, and adalimumab.

[31514420]

What is the role of Adamts18 in hormone receptor signaling?

Adamts18 links luminal hormone receptor signaling to basement membrane remodeling and stem cell activation.

[32218432]

Is belimumab effective for the lupus nephritis?

Yes, belimumab appears to effective for the lupus nephritis.

[32591783, 24014569, 32537456, 33186226, 29514612, 25969652, 26712500, 32937045, 32755035]

Which are the lactate isomers?

Lactate contains a chiral carbon and thus has two optical isomers-d-lactate and l-lactate.

[27119568, 29501496, 32365804]

What is the function of the Eyeless associated gene in Drosophila?

Eyeless (ey) also known as Pax6, is one of the most critical transcription factors for initiating the entire eye development in Drosophila.

[9177348, 11842182, 19527703, 11536287, 30706848, 21208993, 19406113, 9428513, 11445545, 28993201, 10357938, 15253940, 24009524, 9892673, 11685574, 11335113, 12654291, 7892602, 11735383, 9159393, 19666017, 10198632, 11804780, 11861484, 16879729, 11153010, 30295802]

Are enhancers directional in their targeting of gene promoters?

Promoters initiate transcription in opposite directions and are separated only by a short enhancer region, which is likely to regulate both promoters simultaneously. Most enhancers are able to regulate promoters on either side.

[10550664, 15198202]

Has dupilumab been FDA approved for atopic dermatitis?

Yes, dupilumab has been approved by FDA for atopic dermatitis.

[30785362, 31603635, 32344789, 31364023, 32439390]

Describe ReactomeGSA

ReactiveomeGSA is a novel resource for comparative pathway analyses of multi-omics datasets. Data from different species is automatically mapped to a common pathway space. Public data from ExpressionAt Atlas and Single Cell ExpressionAtlas can be directly integrated in the analysis. reactomegSA greatly reduces the technical barrier for multi-CSF, cross-species, and Comparative Pathways analysis.

[32907876]

What is the role of phenylbutyrate–taurursodiol for amyotrophic lateral sclerosis?

Treatment of amyotrophic lateral sclerosis patients with phenylbutyrate–taurursodiol was associated with both functional and survival benefits.

[33063909, 32877582]

What is known about growth arrest-specific 6 protein?

Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein secreted by immune cells, endothelial cells, vascular smooth muscle cells, and adipocytes. Recent studies indicate that Gas6 and receptors of the TAM (Tyro3, Axl, and Mer) family may be involved in the pathogenesis of obesity, systemic inflammation, and insulin resistance.

[30346880, 32969596, 31583710]

What is Leptomeningeal disease?

Neoplastic leptomeningeal disease (LMD) represents infiltration of the leptomeninges by tumor cells.

[28802798]

What percent of Rheumatoid Arthritis (RA) patients are not responding to anti-TNF therapy?

These therapies are, however, expensive and 30% of patients fail to respond.

[17985409, 19211043, 17354663, 21431944, 25733803, 19389230, 25504080, 20444755, 16705046, 22133052, 27974105, 18713756]

Which recombinant antibody therapeutics were granted marketing approval in 2014?

Six recombinant antibody therapeutics (vedolizumab, siltuximab, ramucirumab, pembrolizumab, nivolumab, blinatumomab) were granted their first marketing approvals in 2014.

[25484055]

What is caused by BACH2-related immunodeficiency?

Affected subjects of a syndrome of BACH2-related immunodeficiency and autoimmunity (BRIDA) had lymphocyte-maturation defects that caused immunoglobulin deficiency and intestinal inflammation. The mutations disrupted protein stability by interfering with homodimerization or by causing aggregation.

[28530713]

Should cerebrolysin be used for aneurysmal subarachnoid hemorrhage?

No. Randomized clinical trial did not find any superior effects of cerebrolysin for patients with aneurysmal subarachnoid hemorrhage.

[33143640, 30414051]

Do bacteria release extracellular vesicles?

Yes, Bacterial extracellular vesicles (EVs) are bilayered lipid membrane structures, bearing integral proteins and able to carry diverse cargo outside the cell to distant sites.

[31633842, 31776460, 33264437]

What is the effect of the venom of the cone snail, Conus tulipa?

Thus, C. tulipa venom comprised both paralytic (putative ion channel modulating α-, ω-, μ-, δ-) and non-paralytic (conantokins, con-ikot-ikots, conopressins) conotoxins.

[12824165, 30669642, 31780714, 2180939, 9080592, 12507705, 25605914, 30747102]

Which component of the Influenza A Virus affects mRNA transcription termination?

Defective Pol II termination occurs independently of the ability of the viral NS1 protein to interfere with host mRNA processing. Instead, this termination defect is a common effect of diverse cellular stresses and underlies the production of previously reported downstream-of-gene transcripts (DoGs).

[30177761, 6328745, 18631147, 21118126, 29768209, 21207185, 1371285]

Which two genes are predominantly considered by warfarin initial dosing algorithms?

Polymorphisms in CYP2C9 and VKORC1 are taken into consideration by warfarin initial dosing algorithms.

[31673144, 32710457]

Describe MSstatsTMT

MSstatsTMT is a general statistical approach for relative protein quantification in MS- based experiments with TMT labeling.

[32680918]

Is Tranexamic acid effective for intracerebral haemorrhage?

No. According to clinical trial data tranexamic acid does not improve outcomes of patients with intracerebral haemorrhage.

[31322116, 31008298, 32637645, 33128912, 29778325]

Are interferons defensive proteins?

Yes, The innate immune system, in particular the type I interferon (IFN) response, is a powerful defence against virus infections.

[31711273, 32755617, 31783148, 32827605]

What effect does Methylsulfonylmethane (MSM) have on inflammation?

Methylsulfonylmethane (MSM) is a sulfur-based nutritional supplement that is purported to have pain and inflammation-reducing effects.

[23011466, 33114764, 29214616, 25461402, 23013531, 32466845, 32562081, 27447722, 28666801, 17516722, 30038844, 32619204, 19336900, 27844051, 28300758, 26684635, 23595869, 32429534, 21463646, 32234879, 12387309, 28736511]

What is particular about the 3D structure of the inactive X chromosome?

The mammalian inactive X chromosome (Xi) condenses into a bipartite structure with two superdomains of frequent long-range contacts, separated by a hinge region. This specific bipartite organization of the inactive X chromosome that probably plays an important role in maintenance of gene silencing.

[27062886, 26248554, 18789978, 27492478, 29654302]

Why mothers with a CYP2D6 ultrarapid metabolizer phenotype may expose their infants to risk of adverse events when taking codeine while breastfeeding?

Mothers with a CYP2D6 ultrarapid metabolizer phenotype may expose their infants to risk of adverse events when taking codeine while breastfeeding, by producing more of the active metabolite, morphine.

[28696420]

Which R package can infer protein-protein interactions via thermal proximity coaggregation (TPCA)?

Rtpca is an R package implemented methods for inferring protein-protein interactions (PPIs) based on thermal proteome profiling experiments of a single condition or in a differential setting via an approach called thermal proximity coaggregation. It offers user-friendly tools to explore datasets for their PPI predictive performance and easily integrates with available R packages.

[32717044]

What is the mechanisms of action of Evinacumab?

Evinacumab is angiopoietin-like protein 3 (ANGPTL3) monoclonal antibody that was shown to substantially reduce low-density lipoprotein cholesterol concentration.

[31242752, 32492513, 31578082, 31008773, 30403015, 32520777, 32332430, 33278127, 30011918, 33130482, 32841138, 32511037, 31843957, 28538136, 33196153, 32813947, 33295805, 31100030]

Do honey contain diastases/amylases?

Yes honey contain the protein amylase.

[17995872, 22483889, 32424606, 595894]

What year was the first successful human heart transplant performed?

The first human heart transplant in 1967 was performed using a deceased donor heart,

[11391041, 15056065, 32493185, 16009314, 19287813, 31102725, 25795463, 29262951, 29492391, 15726762, 32065475, 29664541, 18702960, 10272755, 30083541, 6378042, 15061629, 29191294]

Which disease is monitored in the BIOCURA cohort?

Rheumatoid Arthritis (RA) is one of the diseases that is monitored in the BIOCURA cohort. There are other diseases that are monitored as well, such as breast cancer, ovarian cancer, and thyroid cancer.

[27749223, 27631111, 28650254, 29808722, 27558398]

Which gene is associated with response to abacavir?

Large studies established the effectiveness of prospective HLA-B*57:01 screening to prevent HSRs to abacavir.

[23204921]

Is adenosine signaling prognostic for cancer outcome?

Yes, adenosine signaling has been shown to be prognostic for cancer outcome.

[31953314]

Which drugs are included in the CNIC polypill?

CNIC polypill includes atorvastatin 40mg, ramipril 10mg and aspirin 100mg.

[31850802, 31983653]

Which human tissue synthesize CRP?

CRP is predominantly produced in the liver in a native pentameric form (nCRP).

[31840602, 31758923]

What is the relationship between the X chromosome and a neutrophil drumstick?

In particular, up to 17% of neutrophil nuclei of healthy women exhibit a drumstick-shaped appendage that contains the inactive X chromosome.

[11534818, 2176962, 7416166, 7828232, 28374668, 3721910]

The formation of which inflammatory molecule is regulated by MAP3K8 (TPL2)?

MAP3K8 (Tpl2) regulates the formation of inflammatory molecule IL-1β

[24586913, 30463908, 19933865, 24517997, 20736176, 27261457, 32253104, 26215868, 19808894]

Which company produces the Oncomine Dx target test?

The Oncomine Dx Target Test Panel is produced by Thermo Fisher Scientific.

[31349061]