Datasets:

rag-datasets

/

rag-mini-bioasq

like 19

Follow

RAG Datasets 12

Are Toll-like receptors (TLRs) induced by microbes?

Yes, Gram-negative bacteria and endogenous molecules coordinate to trigger inflammatory cascades via Toll-like receptor 4 to induce excessive expression of cytokines such as tumor necrosis factor-α and to activate NLRP3 inflammasome, a multiprotein complex that processes pro-interleukin-1β into its mature form.

[31462144, 31799626, 31712269, 33075123, 31865463]

What is a decoy exosome?

exosomes display a large repertoire of tumor antigens that induce autoantibodies and exert a decoy function against complement-mediated cytotoxicity.

[27843457, 21364924, 30651550, 22396543]

Can you summarize Myasthenia Gravis?

Myasthenia gravis (MG) is a neuromuscular disease which affects the central nervous system, dorsal root ganglia of the spinal cord, heart and in certain cases the pancreas. Two thirds of MG cases result from sporadic genetic mutations, not inheritance, but their offspring may inherit it from them.

[20067169, 28654435, 21087811, 22428294, 33223079, 16155434, 16037773, 31998320, 27690672, 11886578, 19209651, 28941526, 31937334, 24141560, 32859770]

What 3 disorders are commonly associated with Kaufman-McKusick syndrome?

McKusick-Kaufman syndrome (MKKS) is a rare, recessively inherited syndrome reported mainly in young children. It is characterised by vaginal atresia with hydrometrocolpos, postaxial polydactyly, and congenital heart defect.

[22470656, 22090721, 25635170, 12026212, 10802661, 6495304, 3314666, 29866251, 12107442, 10465109, 16418967, 9467007, 8985498, 1853883, 25017277, 15772095]

Is Ixodes a species of tick?

Ixodes is a family of hard ticks.

[14570115, 30914054, 31720842, 23975565, 31887120, 28173840, 25035799, 12938010, 25333277, 32327327, 26586535, 27286701, 14500917, 19998007, 33002807, 12422585, 32723642, 25434042, 27473852, 11296828, 23444797, 20101443, 19184580, 16350531, 33010631, 30079309, 17089744, 23077588, 26336217, 21153754, 29448923, 21028959, 25236960, 33059172, 31031164, 12880241, 27263092, 31943036, 30207871]

What is the active ingredient in the most common hand sanitizer?

Evaluation of a benzalkonium chloride hand sanitizer in reducing transient Staphylococcus aureus bacterial skin contamination in health care workers.

[32461409, 29502883, 32459621, 28279942, 32790662, 31668935, 29322859, 26282413, 30676276, 25726133, 33134040, 30969148, 29987197, 21219741, 21730079]

Which was the first oral drug for the treatment of multiple sclerosis by the US Food and Drug Administration (FDA)?

FTY720 (Fingolimod) was approved as the first oral drug for the treatment of multiple sclerosis by the US Food and Drug Administration (FDA) in 2010.

[31785606]

Which S1P receptors does fingolimod bind to?

Pharmacologically, fingolimod has been characterized as a non-selective agonist of all of the S1P receptors (S1PR), with the exception of S1P2.

[30776422]

What was fingolimod synthesized from?

FTY720 (fingolimod, Gilenya®) was synthesized from myriocin, one of the metabolites of the fungus Isaria sinclairii known from traditional Chinese medicine for its antibacterial and energy boosting effect.

[30776422]

What does fingolimod do to the grey matter of the brain?

Fingolimod has been shown to reduce/prevent both focal and diffuse grey matter (GM) damage in active multiple sclerosis. The percentage of patients with new cortical lesions (CL) (13.5 vs. 89%, p < 0.001) and the percentage of GM volume change was lower in the fingolimod treated group (p < 0.001). The regional analysis revealed that the treated group had also less volume loss in thalamus, caudatus, globus pallidus, cingulate cortex, and hippocampus (p < 0.001), as well as in, cerebellum, superior frontal gyrus, and insular-long gyrus (p < 0.05).

[29938336]

What doses of fingolimod were administered during the FREEDOMS trial?

In the FREEDOMS trial fingolimod was administered at 0.5mg or 1.25mg doses.

[22494956]

How many patients were enrolled in the FREEDOMS clinical trial?

FREEDOMS study, a randomised, double-blind study included 1272 patients with relapsing-remitting MS.

[22494956]

What is blepharospasm?

The neurophysiological disruptions underlying blepharospasm, a disabling movement disorder characterized by increased blinking and involuntary muscle spasms of the eyelid, remain poorly understood.

[14871168, 28629634, 16690695, 9163399, 27064462, 27333537, 8098852, 21221669, 23747003, 19273924, 17986501, 18786893, 32091988, 28017248, 32250472, 30838249, 31889644, 539757, 10732662, 19039478]

Explain the action of Balovaptan.

Balovaptan is a low-molecular-weight, orally active, hydrophilic non-peptide molecule that blocks Vasopressin-1a. It is approved for the treatment of autism spectrum disorders (ASD).

[32935287, 31043521, 31951127]

what is the effect of Bisphenol A in the body?

Bisphenol A (BPA) is an endocrine-disruptor compound that exhibits estrogenic activit

[29874946, 32777607, 12387626, 27177772, 17622711, 12767684, 27641926, 33049673, 33049674, 12573901, 17689037, 22470480, 24171222, 25619032, 27089241, 32891999, 12505450, 28774890, 19890158, 21705716, 30359670, 30257398, 32861950, 26821503]

List the main proteins found in human saliva.

Amylases Cystatins Immunoglobulins Mucins

[32260553, 30632771, 16440601, 31998446]

Is HbA1c an ideal biomarker of well-controlled diabetes?

No. The HbA1c is a biomarker with a central role in the diagnosis and follow-up of patients with diabetes mellitus, although not a perfect one. It is associated with high morbidity and mortality, and is not an ideal biomarker for assessment of well-controlled diabetes.

[32913038]

Which tool has been developed for microRNA-target enrichment and network-based analysis?

MIENTURNET (MicroRNA ENrichment TURned NETwork) is a web tool that receives in input a list of miRNAs or mRNAs and tackles the problem of prioritizing miRNA-target interactions by performing a statistical analysis followed by a fully featured network-based visualization and analysis. The statistics is used to assess the significance of an over-representation of miRNA-target interactions and then MIENTURNET filters based on the statistical significance associated with each miRNA-target interaction. In addition, the holistic approach of the network theory is used to infer possible evidences of miRNA regulation by capturing emergent properties of the miRNA-target regulatory network that would be not evident through a pairwise analysis of the individual components.

[31684860]

List example genes that SWIM tool has identified and which are down-regulated in glioblastoma

SWIM is a software able to unveil a small pool of genes - called switch genes - critically associated with drastic changes in cell phenotype. Applying SWIM to the expression profiling of glioblastoma stem-like cells and conventional glioma cell lines identifies switch genes related to stem-like phenotype. SWIM identifies 171 switch genes that are all down-regulated in glioblastoma stem-like cells. This list encompasses genes like CAV1, COL5A1, COL6A3, FLNB, HMMR, ITGA3, ITGA5, MET, SDC1, THBS1, and VEGFC, involved in "ECM-receptor interaction" and "focal adhesion" pathways.

[30497369]

Describe SWItchMiner (SWIM)

SWItchMiner (SWIM) is a wizard-like software implementation of a procedure, previously described, able to extract information contained in complex networks. Specifically, SWIM allows unearthing the existence of a new class of hubs, called "fight-club hubs", characterized by a marked negative correlation with their first nearest neighbors. Among them, a special subset of genes, called "switch genes", appears to be characterized by an unusual pattern of intra- and inter-module connections that confers them a crucial topological role, interestingly mirrored by the evidence of their clinic-biological relevance.

[28317894]

What promotes amyloid-peptide beta 42 (Aβ42) accumulation in neuroblastoma cells?

The apolipoprotein (apo) E4 isoform is the strongest risk factor for late-onset Alzheimer's disease (AD). ApoE4 is more susceptible to proteolysis than apoE2 and apoE3 isoforms and carboxyl-terminal truncated apoE4 forms have been found in AD patients' brain. A specific apoE4 fragment, apoE4-165, promotes amyloid-peptide beta 42 (Aβ42) accumulation in human neuroblastoma SK-N-SH cells and increased intracellular reactive oxygen species formation, two events considered to occur early in AD pathogenesis.

[27476701]

Which method has been developed for detection of ATAC-seq or ChIP-seq signals with DNA methylation?

EpiMethylTag is a fast, low- input, low sequencing depth method that combines ATAC-seq or ChIP-seq (M-ATAC or M-ChIP) with bisulfite conversion, to simultaneously examine accessibility/TF binding and methylation on the same DNA.

[31752933]

Which protein is involved in the organization and regulation of pluripotency-associated three-dimensional enhancer networks?

KLF4 is involved in the organization and regulation of pluripotency-associated three-dimensional enhancer networks.

[31548608]

Where is the agouti-related peptide expressed?

Function. Agouti-related protein is expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with lower levels of expression in the testis, kidneys, and lungs.

[31974377, 31995643, 31557134, 31692367]

What is the function of ketohexokinase-A?

The central fructose-metabolising enzyme is ketohexokinase (KHK), which exists in two isoforms: KHK-A and KHK-C.

[31750240, 29604362, 27088854, 26083752]

Are the major royal jelly proteins similar to the yellow proteins?

Yes, Major royal jelly proteins (named MRJP1-5) of honeybee (Apis mellifera), yellow proteins of Drosophila, together with putative proteins found in several bacteria, form a protein family termed the MRJP/yellow family.

[10772900, 15037093]

Which R packages have been developed for studying TADs?

TADCompare is an R Package for differential and temporal analysis of Topologically Associated Domains. SpectralTAD is an R package for defining a hierarchy of topologically associated domains using spectral clustering.

[32689928, 32211023]

Which bioconductor tool has been developed for accessing bacterial regulatory networks?

The Regutools R package to facilitates programmatic access to RegulonDB data in computational biology. regutools gives researchers the possibility of writing reproducible workflows with automated queries to RegulonDB. The regutools package serves as a bridge between RegulonDB data and the Bioconductor ecosystem by reusing the data structures and statistical methods powered by other Bioconductor packages.

[32573705]

Is the Apis mellifera genome available?

Yes, the Apis mellifera genome is available since 2006.

[31965987, 32518251, 32134461, 32384687]

What genes is implicated in myotonic goats and other nondystrophic myotonias?

The gene encoding clcn1, mBNl1, gcic-1, scn4a, clc-1 and dmpk are implicated in myotonic goats and other nondystrophic myotonias.

[12021248, 31669315, 22197188, 18974556, 9392583, 25438602, 26510092, 8855341, 10215406, 32270509, 32129495, 27415035, 23113340, 25088311, 21204798]

Has the olive tree pollen proteome been studied?

Yes, Olive pollen is a major allergenic source worldwide due to its extensive cultivation. We have combined available genomics data with a comprehensive proteomics approach to get the annotated olive tree (Olea europaea L.) pollen proteome and define its complex allergenome.

[31192604]

Is cadherin a plasma membrane marker?

Yes, cadherin is a plasma membrane protein marker.

[31838186, 32044971, 32239671, 32939719]

What impacts stability of genomic imprinting in mouse pluripotent stem cells?

A susceptibility locus on chromosome 13 profoundly impacts the stability of genomic imprinting in mouse pluripotent stem cells.

[32187532]

What are the end products of the shikimate pathway?

The shikimate pathway responsible for the generation of aromatic amino acids

[32538627, 32616740, 32642925, 31961458, 32154231]

What are the uber-operons?

Uber-operons are groups of functionally or transcriptionally related operons, whose gene sets are conserved across multiple reference genomes. Many of the uber-operons correspond to parts of known regulons or biological pathways or are involved in highly related biological processes based on their Gene Ontology (GO) assignments.

[16682449]

Which key gene is involved in syndromic obesity phenotype of patients with 1p21.3 microdeletions?

MIR137 is the key gene mediator of the syndromic obesity phenotype of patients with 1p21. 3 microdeletions.

[22003227, 27822311]

Is cabergoline used for treatment of the Nelson's syndrome ?

Yes, cabergoline has been shown to be effective for treatment of the Nelson's syndrome.

[16845600, 15557761, 10710275, 17574308, 10971110, 26221547, 20702648, 16311416]

Are mucins glycosylated proteins?

Yes, Many members of the mucin family are evolutionarily conserved and are often aberrantly expressed and glycosylated in various benign and malignant pathologies leading to tumor invasion, metastasis, and immune evasion.

[31907968, 31908009, 31904283]

Is carpal tunnel syndrome a type of nerve entrapment?

Carpal tunnel syndrome (CTS) is the most frequent entrapment neuropathy in humans.

[21320832, 12475522, 33141768, 3618059, 32082444, 19280893, 24422297, 18050074, 15605660, 23799199, 28824352, 33151661, 16558255, 23997744, 31634868, 28928252, 23113142, 19756731, 25526716, 32477509, 22492102, 29218119, 31632712, 32174033, 21845587, 31736403, 19534294, 28447963, 10918251, 6756339, 24740988, 28718333]

What is the main manifestation of Liebenberg syndrome?

Liebenberg syndrome (MIM 186550) is a very rare autosomal dominant condition characterized by three main features: dysplasia of all of the bony components of the elbow joint, abnormalities in the shape of carpal bones, and brachydactyly.

[23395106, 23940102, 23587911]

Which IDH inhibitors by Agios Pharmaceuticals have been approved by the FDA?

Enasidenib and ivosidenib, the IDH2 and IDH1 inhibitors developed by Agios Pharmaceuticals, have been approved by the Food and Drug Administration

[31660152]

What is RADICL-seq?

Mammalian genomes encode tens of thousands of noncoding RNAs. Most noncoding transcripts exhibit nuclear localization and several have been shown to play a role in the regulation of gene expression and chromatin remodeling. To investigate the function of such RNAs, methods to massively map the genomic interacting sites of multiple transcripts have been developed; however, these methods have some limitations. RNA And DNA Interacting Complexes Ligated and sequenced (RADICL-seq) is a technology that maps genome-wide RNA-chromatin interactions in intact nuclei. RADICL-seq is a proximity ligation-based methodology that reduces the bias for nascent transcription, while increasing genomic coverage and unique mapping rate efficiency compared with existing methods. RADICL-seq identifies distinct patterns of genome occupancy for different classes of transcripts as well as cell type-specific RNA-chromatin interactions, and highlights the role of transcription in the establishment of chromatin structure.

[32094342]

Which disease is treated with Anti–Siglec-8 Antibody?

Anti-Siglec-8 Antibody was shown to be effective for Eosinophilic Gastritis and Duodenitis. It is also undergoing clinical investigation for treatment of allergic, inflammatory, and proliferative diseases.

[29680938, 31465299, 33085861, 31401630]

What is known about mammalian melatonin receptors?

Melatonin receptors MT1 and MT2 (genes officially named MTNR1A and MTNR1B, respectively) play crucial roles in melatonin-mediated regulation of circadian rhythms, the immune system, and control of reproduction in seasonally breeding animals. The melatonin receptor family is a small group of receptors within the G protein-coupled receptor (GPCR) superfamily. The group comprises of three subtypes which bind melatonin and one member, the melatonin related receptor (MRR), that shares >40% sequence identity with the other melatonin receptors but does not bind melatonin.

[30915128, 12111545, 14521626, 12957828]

What is holoprosencephaly?

Holoprosencephaly (HPE) is a congenital defect of the brain, median structures, and face resulting from an incomplete cleavage of the primitive brain during early embryogenesis . The most common developmental defect is characterized by inadequate or absent midline division of the forebrain into cerebral hemispheres with concomitant midline facial defects in the majority of cases .

[26361024, 6633857, 25590404, 27086438, 25339593, 25218063, 33111505, 29770996, 23112757, 21795094, 15021236, 31528602, 26564444, 8862623]

What is the effect of notch in the division of neural progenitor cells in Drosophila?

The Notch pathway mediates the differentiation of neural progenitor cells in Drosophila. It's an important part of the development of neural stem cells, which are the cells that make up the brain. Notch/HES signaling and MIR-9 signaling are very important for the homeostasis of neural cells. It is thought that notch activation is responsible for the growth of neurons.

[11234018, 25336612, 28573150, 18000541, 19783418, 19059466, 18956012, 15081359, 27466320, 33229432, 30176986, 12100893, 24583034]

In what clinical trials has SAR425899 been tested?

Subcutaneous administrations of SAR425899 were tested in two randomized, placebo-controlled, double-blind clinical trials. In the first trial, healthy overweight volunteers (body mass index [BMI] 25-30 kg/m2 ; n = 32) received single-ascending doses (0.01-0.1 mg) of SAR425899 or placebo. In the second, a multiple-ascending-dose trial (NCT02411825), healthy normal- to overweight volunteers (BMI 20-30 kg/m2 ; n = 40) and overweight/obese patients with T2D (BMI 28-42 kg/m2 ; n = 36) received daily doses of SAR425899 or placebo over 21 or 28 days, respectively.

[30091218]

Is there a link between rare variants in PPARG and type 1 diabetes?

No. Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes.

[25157153]

What is the mechanisms of action of pexidartinib?

Pexidartinib is small-molecule tyrosine kinase inhibitor that has strong selectivity against colony-stimulating factor 1 receptor.

[33143617, 31602563, 31848580, 30926949, 31258629, 32943455, 31862477, 32251854, 31420495, 30825104, 31240240, 32306101, 31229240, 31213500, 32535390, 32440095]

List pore forming toxins.

cytolysin A α-hemolysin Streptolysin O pneumolysin listeriolysin leukocidin Glabralysin

[31903844, 32041354, 31584206, 31936048, 31852826, 30914205, 32492702]

What syndrome is associated with mutations in lysine methyltransferase 2D KMT2D?

Mutations in lysine methyltransferase 2D (KMT2D) gene, which encodes the catalytic core of a multisubunit chromatin remodeling enzyme, are responsible for the neurodegenerative disorder Kabuki syndrome.

[27573763, 30891914, 24838796, 31935506, 29914387, 24240169, 31282990, 26932671, 31813957, 28007623, 32083401, 29725259, 24705355, 28475860, 31465303, 31816409, 32803813, 26194542, 30980591]

Does steroid 5A-Reductase deficiency lead to hermaphroditism?

Yes, steroid 5A-reductase deficiency can lead to hermaphroditism.

[11515490, 17663907, 8768837, 8110760, 24383016, 20850730, 10564874, 8001864, 27693263, 3489839, 21147889, 10458450, 20511729, 1944596, 23633205, 20132346, 8302780]

Has ubrogepant entered clinical phase III trials?

Yes, ubrogepant has entered phase III trials.

[32011192, 31758661, 32648856]

How many nucleotides long is the HOTAIR CNE?

The HOTAIR CNE is a 32-nucleotide long conserved noncoding element

[32268280]

What symptoms are included in the narcolepsy pentad?

Narcolepsy is a chronic sleep disorder characterized by a pentad of excessive daytime sleepiness (EDS), cataplexy, sleep paralysis, hypnagogic/hypnopompic hallucinations, and disturbed nocturnal sleep.

[32941089, 31931470, 30595352, 28726523, 28162143]

What is the function of osteolectin?

C-type lectin domain family 11 member A (Clec11a), also known as stem cell growth factor (SCGF), C-type lectin superfamily member 3 (CLECSF3), or osteolectin was initially identified as a growth factor for hematopoietic progenitor cells.

[30632962, 33053358, 32003015]

What is ECMO?

Extracorporeal membrane oxygenation (ECMO) is an increasingly prevalent treatment for acute respiratory failure (ARF)

[26837253, 25608845, 25176974, 23817232, 28413074, 29808279, 29768983, 29050526, 24809246, 32092196, 28948652, 32144062, 23594433, 30386759, 23406535, 25711946, 32094031, 19088593, 19806801, 28533721, 27113690, 24651227, 895593, 25789816, 22914430]

Which diseases are associated with the Yaa gene?

The Y-linked autoimmune accelerating gene mutation (yaa), first discovered in the BXSB mouse strain, is known to accelerate spontaneous autoantibody production and subsequent development of lupus disease. It has also been shown to be associated with various autoimmune conditions such as lupus-like syndrome, collagen induced arthrits and glomerulonephritis.

[8181531, 16777955, 9743333, 2599002, 18521959, 7843228, 12594250, 8040305, 15634937, 10753498, 9862363, 1537372, 9754557, 7930846]

Which receptors does bimagrumab block?

Bimagrumab blocks the activin type II receptors.

[30095981]

Are PDXK mutations linked to polyneuropathy?

Yes, PDXK mutations are linked to polyneuropathy.

[32522499, 31187503]

Is avelumab effective for urothelial carcinoma?

Yes. Avelumab is an anti-programmed death-ligand 1 monoclonal antibody that is approved for the treatment of urothelial carcinoma.

[32945632, 29103968, 31940998, 29217288, 32762233, 32146152, 28375787, 30481100, 28585615, 33037118, 31286802, 30021426, 29540084, 30004857, 32135514, 31553054, 31807039]

What tissues have been studied by circadian proteomics?

Retina Liver

[17726681, 30973132, 31034157]

Is MIS-C or Multisystem Inflammatory syndrome in children a complication of Covid-19?

Is MIS-C or Multisystem Inflammatory Syndrome in children a complication of Covid-19? Yes, it is.

[32827525, 33180935, 32532619, 32755212, 33055501, 33263756, 32511374, 33180050, 33263635, 33278107, 32837148, 32493734, 33243303, 33300011, 32935083, 33042116, 33110725, 32975439, 32496723, 33295957, 32923992, 32631771, 33011038, 33042918, 33083367, 32839782, 33269352, 32925547, 33217259, 32966765, 32953455, 32946801, 32995826, 32463092]

Which RNA polymerase transcribes enhancer RNAs?

Analogously to mRNAs, the non-protein-encoding enhancer RNAs are synthesized by RNA Pol II and post-transcriptionally modified by addition of a 5'-cap and a 3'-poly (A) tail.

[28533025, 31824865, 3299107, 30448228, 32060325, 2218723, 26219400, 25578728, 26319018, 29378668, 3031599, 26864944, 24599251, 27662872, 20393465, 27662874, 2986013, 3462718]

Name the three phase 3, randomized, double-blind, placebo-controlled that assessed galcanezumab?

Galcanezumab has been assessed in the phase 3, randomized, double-blind, placebo-controlled EVOLVE-1, EVOLVE-2 and REGAIN studies.

[32319039]

Is co-loss of BRCA2-RB1 associated with better prognosis for prostate cancer patients?

No. Co-loss of BRCA2-RB1 in human prostate cancer cells induces an epithelial-to-mesenchymal transition, which is associated with invasiveness and a more aggressive disease phenotype.

[31796516]

Which drugs were investigated in the ALPHEUS trial?

ALPHEUS study examined if ticagrelor was superior to clopidogrel in reducing periprocedural myocardial necrosis in stable coronary patients undergoing high-risk elective percutaneous coronary intervention (PCI).

[33202219, 32473356]

Which cell secretes the enzyme tryptase?

Degranulation of mast cells (MCs) releases several mediators such as vascular endothelial growth factor (VEGF), chymase, tryptase, histamine, and cytokines.

[31709696, 31853339, 31858758]

What disease does BCG immunotherapy used to treat?

Bacillus Calmette-Guérin (BCG) immunotherapy is used for treatment of bladder cancer.

[1244548, 26000263, 28488840, 31755155, 26032289, 32577059, 31900581, 10575270, 15281319, 27241256, 27960233, 18976938, 8573479, 23517232, 31307960, 178234, 25794874, 12057150, 19967427, 12084297, 24064971, 19957324, 9259090, 6342739, 30893148, 29576423, 7016300, 4412271, 28807024]

Which epigenetic marks are deposited by PRC1?

PRC2 induces histone H3 lysine 27 (H3K27) trimethylation (H3K27me3), which is subsequently read by PRC1 that further catalyzes H2A monoubiquitination (H2Aub1), creating a transcriptional silent chromatin conformation.

[25071008, 26151332, 25754661, 27630184, 18974828, 21311219, 19462008, 27410265, 23706298, 26564795]

Does erenumab target the calcitonin gene-related peptide?

No, erenumab targets the calcitonin gene-related peptide receptor.

[30651064]

Which key gene is involved in interstitial 6q25 microdeletion syndrome?

Interstitial deletions of the long arm of chromosome 6 are rare. Clinically, these deletions are considered to be part of a unique microdeletion syndrome associated with intellectual disability and speech impairment, typical dysmorphic features, structural anomalies of the brain, microcephaly, and non-specific multiple organ anomalies. ARID1B is the key gene behind 6q microdeletion syndrome.

[26754677]

Brensocatib was tested for treatment of which disease?

Brensocatib was tested for bronchiectasis. Brensocatib in patients with bronchiectasis was associated with improvements in bronchiectasis clinical outcomes.

[32897034]

What is the function of the protein Cuf1?

Cuf1 is a copper-sensing transcription factor.

[17384198, 11274192, 21489137, 12244050, 18723604]

How many groups of viruses exist in the Baltimore Classification?

There are seven "Baltimore classes" (BCs) that define the major features of virus reproduction.

[32132243, 28588308]

What is the effect of Dkk1 in Wnt signaling?

Transcriptional silencing of the Wnt-antagonist DKK1 is a secreted protein that antagonizes Wnt signaling and plays essential roles in vertebrate embryogenesis.

[21861760, 18505732, 20142103, 22363428, 20161711, 20618428, 29763912, 29165387, 24671437, 14695885, 30216540, 23261660, 28849121, 15378020, 24520934, 21811562, 20543981, 14695408, 26880631, 17295608, 11044603]

What is bimagrumab

Bimagrumab is a fully human monoclonal antibody that blocks the activin type II receptors, preventing the activity of myostatin and other negative skeletal muscle regulators.

[29566437, 27167138, 30095981, 29226558]

List orally bioavailable MPS1 kinase inhibitors

1 h-pyrrolo [3,2-c] pyridine, cct271850, nms-p715, 4-aminopyrazalo,bos172722 and cct251455.

[29380674, 28334731, 31575759, 27335255, 21159646]

Can radiosurgery be used for the DNET tumors?

Yes, radiosurgery is used for the DNET (Dysembryoplastic neuroepithelial) tumors. However, the level of evidence is limited.

[28868186, 17240596]

What are commensal bacteria?

The gut microbiota is composed of a large number of microbes, usually regarded as commensal bacteria. Maintenance of the commensal bacteria that comprise the gut microbiome is essential to both gut and systemic health.

[30672882, 31049923, 32758517, 33186243]

What disease is associate with defects in both the KDM6A (lysine specific demethylase 6A) and KMT2D (lysine methyltransferase 2D)

Over the last 20 years, mutations in five key COMPASS complex genes have been linked to three human congenital syndromes: Kabuki syndrome (type 1 [KMT2D] and 2 [KDM6A]

[31883305, 31924266, 29725259, 24838796, 29073101, 31282990, 25934606, 31935506, 32817139, 27028180, 31740281, 30509212]

Which transcription factor regulates emergency granulopoiesis?

The transcription factor CCAAT/enhancer binding protein β (C/EBPβ) plays critical roles in the differentiation and proliferation of hematopoietic stem cells.

[25940801, 19796237, 23382991, 26267538, 23024276, 29973462, 29382715, 16751774, 20581311]

When did eptinezumab get its first FDA approval?

In February 2020, eptinezumab was approved in the USA for the preventive treatment of migraine in adults.

[32266704]

Which database exists that contains regulatory sites for splicing in human basal ganglia?

Braineacv2 has been identified as a database that contains regulatory sites for splicing in human basal ganglia.

[32098967]

Should minocycline be used for mild Alzheimer disease?

No. Minocycline did not delay the progress of cognitive or functional impairment in people with mild Alzheimer disease during a 2-year period.

[31738372]

What is pyroptosis?

Pyroptosis is an inflammatory form of cell death triggered by certain inflammasomes, leading to the cleavage of gasdermin D (GSDMD) and activation of inactive cytokines like IL-18 and IL-1β. Pyroptosis has been reported to be closely associated to some diseases like atherosclerosis and diabetic nephropathy. Recently, some studies found that pyroptosis can influence the proliferation, invasion and metastasis of tumor, which regulated by some non-coding RNAs and other molecules.

[31733200, 31710896, 30917630, 31756255]

What is a HapMap

HapMap is a international effort for creating an annotated haplotype map of the world’s most commonhaplotype sequences.

[17568388, 17922574, 16877472, 19913122, 16434598, 20869033, 14685227, 16374835, 21356867, 22844100, 22319179, 17943122, 18453083, 12615007, 15454560, 21210977, 15587301, 19933162, 19286890, 17033966, 16982009]

Which cancer types are associated with mutations in the TWIST1 gene?

Loss-of-function mutations of TWIST1, a catalytic component of polycomb repressive complex 1, are observed in ~\n10% of all human cancers, including gastric, non-small cell lung, breast ductal carcinoma, nonsmall cell lung cancer, prostate cancer, ovarian cancer, breast tumor, papillary thyroid cancer, and gastric cancer.

[19863427, 29477381, 30265861, 20689556, 29455655, 24117170, 23364532, 29123266, 21502402, 27524420, 30272327, 29452232, 21876555, 28466252, 19373776, 25368021, 17437280, 28851812, 25892968, 25622896, 23623921, 21330172]

What did the RESILIENT study investigate?

A global, randomized, double-blind placebo-controlled study was conducted to confirm that BYM338 (bimagrumab), an anti-activin type II receptor antibody, improves motor function in patients with sporadic inclusion body myositis after 52 weeks' treatment consisting of intravenous administration every 4 weeks at doses of 10, 3, and 1 mg/kg.

[31761834]

List features of the Thrombotic Thrombocytopenic Purpura pentad.

Thrombotic thrombocytopenic purpura (TTP) is typically characterized by the symptomatic pentad of fever, thrombocytopenia, microangiopathic hemolytic anemia, neurologic abnormalities, and renal failure.

[2647685, 12753286, 33024522, 16616715, 25512716, 26634125, 19665681, 8427289, 9360410, 12423834, 21850657, 16913442, 12938786, 23767207, 21415981, 18097325, 30447150, 23738162, 1605172, 12745043, 16104532, 32699732, 11399382, 29270999, 1821908, 1171419, 7863389, 22574558, 29340125, 22233953, 32190437, 23263974, 4038757, 29123569, 17525362, 30072561, 10541941, 10775033]

What are organoids?

Organoids are 3D physiological in vitro structures that recapitulate morphological and functional features of in vivo tissues and offer significant advantages over traditional cell culture methods.

[32865304, 33068633, 32984947, 33241206]

List 3 therapeutic uses for botulism toxin.

Botulinum toxin injections are effective in relieving focal spasticity resulting from upper motor neuron injuries, migraine headaches, over active bladder and to relieve pain in the Sacroiliac Joint.

[31579938, 19837283, 17119144, 31408270, 29173661, 20664247, 33008506, 32923741, 17458494]

What is the role of Tcf3 in the maintenance of pluripotency?

Tcf3 is an integral component of the core regulatory circuitry of ES cells, which includes an autoregulatory loop involving the pluripotency regulators. Tcf3 co-occupies promoters throughout the genome in association with the pluripotency regulators Oct4 and Nanog. Tcf3 down-regulation modulates the lineage differentiation potential of mouse embryonic stem cells through Wnt signaling. Tcf3 down-regulation is a necessary step towards Wnt-mediated suppression of differentiation. Depletion of Tcf3 enables the maintenance of undifferentiated mouse ESCs.

[21685889, 29299140, 28288968, 30115631, 18347094, 23658527, 23040478, 29513567]

What pathological condition is MK-1602 used for?

MK-1602 has been assessed in clinical trials for the acute treatment of migraine.

[28644160, 27269043, 29136283, 31758661]

Is there an association of alterations in ADCY7 and ulcerative colitis?

Yes. Genome-wide analyses indicate a association between mutations in ACVR1 and ulcerative colitis due to loss-of-function mutations in ADCY7.

[28067910]

What is the mechanism of action of satralizumab?

Satralizumab is a humanized anti-interleukin-6 (IL-6) receptor monoclonal recycling antibody that has been approved for the treatment of neuromyelitis optica spectrum disorder (NMOSD).

[33167776, 32333898, 31774956, 33011853, 33059216, 30623348, 32306778, 33301078, 32304439, 32228250, 32731771, 32797372, 32348222]

Are mucin overexpression associated with disease?

Yes, mucins are overexpressed in various malignancies and inflammations.

[31729101, 33300069, 32195770, 31837357]

What are the 4 types of holoprosencephaly?

Holoprosencephaly is a rare congenital disorder which results from failure of cleavage or incomplete differentiation of the forebrain structures at various levels or to various degrees . Depending on the degree of involvement, it is classified into 4 types: Alobar, Semilobar, Lobar, and Middle interhemispheric fusion variant .

[15301825, 6431778, 28050387, 17001700]

Which yeast genes encode for condensin?

Smc2-Smc4 forms the core of the Saccharomyces cerevisiae condensin, which promotes metaphase chromosome compaction . Both SMC2 and SMC4 are essential for chromosome transmission in anaphase . Smc 2-8 suppresses catenanes accumulation, mitotic arrest and growth defects induced by histone depletion at semi-permissive temperature .

[12719426, 25300489, 10749931, 10811823, 16100111, 26904946, 12783798, 10485849, 11846874]

What is another name for the drug AMG334?

AMG334 is also called erenumab.

[28240610]