Datasets:

rag-datasets

/

rag-mini-bioasq

like 14

Is istiratumab effective for pancreatic cancer?

No. In clinical trial, istiratumab failed to improve efficacy of standard of care for pancreatic cancer.

[31912800]

What is the human proteoform project?

Top-down proteomics is emerging as a preferred approach to investigate biological systems, with objectives ranging from the detailed assessment of a single protein therapeutic, to the complete characterization of every possible protein including their modifications, which define the human proteoform.

[34047392, 32118252, 34767442, 34472376, 34539228, 32967423]

Telomestatin is derived from what organism?

Telomestatin is a natural macrocyclic compound derived from Streptomyces anulatus 3533-SV4

[11878947, 15283144, 27632666, 34285374, 12810655]

Which plant is khellin extracted from?

Khellin is extracted from the seeds of the plant Ammi visnaga.

[24925412]

Describe ANTISOMA

The ANTISOMA method is a computerized pipeline for the reduction of the aggregation tendency of monoclonal antibodies (mAbs) based on an automated amino acid substitution approach. The method is available online at http://bioinformatics.biol.uoa.gr/antisoma.

[32468552]

Which factors are inhibited by Abelacimab?

Abelacimab is a novel dual inhibitor of Factor XI and Factor XIa.

[34297496, 34714969]

What is vesiduction?

'Vesiduction' as a fourth mode of intercellular DNA transfer.

[32784449, 32363801]

What is the route of administration of eptinezumab?

Eptinezumab is administered intravenously.

[32266704]

What kind of approaches you need to combine in order to manage Familial spontaneous pneumothorax?

Clinical, radiological and genetic approaches

[34145047]

What is the mechanism of action of Vericiguat?

Vericiguat is a stimulator of soluble guanylate cyclase. It was developed for treatment of chronic heart failure with reduced ejection fraction.

[32458378, 33770393, 34410527, 33850913, 34478114, 33032741, 28586537, 34157357, 34086190, 33030703, 27545139, 32749493, 32222134, 34291399, 31096775, 29032136, 34074190, 34431706, 33395323]

What is the origin of HEp-2 cells?

human larynx epidermoid carcinoma cell line (HEp-2)

[32409089, 30702281, 32384969, 25658113]

Does bleomycin cause lung toxicity?

Pulmonary toxicity is a devastating complication of bleomycin chemotherapy.

[1689606, 1690503, 29269387, 21602446, 17034512, 10783125, 2425242, 1696541, 12771616, 7679525, 28121640, 27190828, 30902828, 6205617, 31809714, 28185527, 27241272, 25026360, 15992893, 26834240, 2582337, 9806661, 30755913, 6167758, 25951185, 33647319, 2443992, 30398042, 6165468, 1711838, 2413151, 6192740, 30464999, 2449257, 26888428, 32079853, 24195693, 83311, 31673206, 7679991]

What is another name for bimagrumab

Bimagrumab also goes by the name BYM338.

[32690797]

What is STATegra?

STATegra is a comprehensive multi-omics dataset of B-cell differentiation in mouse. It includes measurements from up to 10 different omics technologies applied to the same biological system, namely the well-studied mouse pre-B-cell differentiation.

[31672995]

What is the generic name of the Xofluza?

Baloxavir marboxi is the generic name of Xofluza. It is approved for influenza.

[29623652, 33497124, 30983160, 30710642, 30766008, 30852344, 32601915, 34348638]

Is Keutel syndrome a common genetic disorder?

No, Keutel syndrome (OMIM 245150) is a very rare syndrome

[23857752, 32821457, 23917590]

Is fusobacterium associated with Lemierre's syndrome?

Lemierre's syndrome is a rare condition that results from oropharyngeal infection with the gram-negative, anaerobic Fusobacterium necrophorum.

[22464641, 16516355, 14595080, 18552584, 25431696, 26117393, 15777309, 20954654, 20181152, 30700448, 31211045, 30648745, 34235050, 25560619, 32455086, 32371121, 24942004, 23573433, 32257468, 32257727, 21546562, 31843654, 8784713, 28736715, 22633566, 20163040, 32742883, 30775398, 27693542, 11399017, 22668650, 34758377, 18330604, 2649965, 29796209, 26793462, 17934077]

What is the synonym of MK-1602?

MK-1602 is also named Ubrogepant.

[31758661]

How many families did the 100,000 Genomes Pilot enrol?

The U.K. 100,000 Genomes Project is in the process of investigating the role of genome sequencing in patients with undiagnosed rare diseases after usual care and the alignment of this research with health care implementation in the U.K. National Health Service. Other parts of this project focus on patients with cancer and infection. A pilot study was conducted involving 4660 participants from 2183 families, among whom 161 disorders covering a broad spectrum of rare diseases were present.

[34758253]

What is CIS43LS?

CIS43LS is an antimalarial monoclonal antibody with an extended half-life against infection with Plasmodium falciparum.

[34511592, 34379916, 33332286]

List the main salt-inducible kinases.

SIK1 SIK2 SIK3 HDAC4 HDAC5

[34056256, 34350957, 33989615, 33861845, 34196217, 33148508, 33688765]

Unlike DNA, RNA is not methylated, yes or no?

In addition to DNA methylation, reversible epigenetic modification occurring in RNA has been discovered recently. The most abundant type of RNA methylation is N6-methyladenosine (m6A) modification, which is dynamically regulated by methylases ("writers"), demethylases ("erasers") and m6A-binding proteins ("readers")

[18567810, 33526437, 28349450, 19808971, 4992370, 16111635, 16424344, 34694619, 27375676, 34694621]

What methodology does the Oncomine Dx target test use?

The Oncomine Dx target test uses the next generation sequencing methodology.

[31349061]

Describe the application of whole genome sequencing in the diagnosis of primary ciliary dyskinesia (PCD)

Genetic testing is an important component of diagnosing PCD, especially in cases of atypical disease history. WGS is effective in cases where prior gene panel testing has found no variants or only heterozygous variants. In these cases it may detect SVs and is a powerful tool for novel gene discovery.

[34556108]

Which CD38 antibody has been shown to be effective for Lupus Erythematosus?

Daratumumab, a human monoclonal antibody that targets CD38, has been used to treat Lupus Erythematosus.

[29720240, 33828555, 32937047]

What is a circRNA?

Circular RNAs (circRNAs) are a new class of non-coding RNA with a stable structure formed by special loop splicing.

[33112505, 32889059, 32667692]

Summarize Fanconi's anemia

Fanconi anemia (FA) is a rare autosomal or X-linked genetic disorder characterized by chromosomal breakages, congenital abnormalities, bone marrow failure (BMF), and cancer.

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Which one of the CYP450 enzymes is the second most frequently implicated in the metabolism of the drugs currently available on the market?

CYP3A4 and CYP2D6 are the most relevant since they metabolize about 50% and 30% of the drugs on the market, respectively.

[32786546]

Describe SBGNview

SBGNview is a tool set for pathway based data visalization

[34864890]

Which diseases can be treated with Itepekimab?

Itepekimab, a monoclonal antibody targeting IL-33, demonstrated clinical activity in asthma, with potential in chronic obstructive pulmonary disease (COPD).

[34706171, 34302758, 34523807]

What is the msDNA?

msDNA is actually a complex of DNA, RNA, and probably protein. It is composed of a small, single-stranded DNA, linked to a small, single-stranded RNA molecule. The 5' end of the DNA molecule is joined to an internal guanosine residue of the RNA molecule by a unique 2'-5' phosphodiester bond. msDNA is produced in many hundreds of copies per cell, but its function remains unknown.

[15459648, 16093702, 29087272, 11525386, 22102774]

Are Epoxyeicosatrienoic acids (EETs) synthesized by cytochrome P450 epoxygenases from arachidonic acid?

Epoxyeicosatrienoic acids (EETs) are fatty acid signaling molecules synthesized by cytochrome P450 epoxygenases from arachidonic acid

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What percentage of currently available drugs are metabolized by CYP3A4?

CYP3A4 metabolizes approximately 50% of the drugs available today on the market.

[32786546]

What is caused by bi-allelic loss-of-function variants in IPO8?

Bi-allelic loss-of-function variants in IPO8 cause a syndromic form of thoracic aortic aneurysm (TAA) with clinical overlap with Loeys-Dietz and Shprintzen-Goldberg syndromes.

[34010605]

What is the mechanism of action of Evinacumab?

Evinacumab is a monoclonal antibody against angiopoietin-like protein 3 (ANGPTL3) that has been shown to reduce low-density lipoprotein cholesterol in patients with homozygous familial hypercholesterolemia.

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Which glands in the bee secretes royal jelly?

hypopharyngeal glands

[26083737, 30272666, 30953617, 31410279]

List the common retinal diseases associated with circRNAs.

Circular RNAs (circRNAs) in whole blood could be served as novel non-invasive biomarkers for retinal degeneration, diabetic retinopathy, proliferative diabetic retinopathy (PDR) and Retinopathy of prematurity (ROP)

[31171902, 32500032, 34858342, 33015046, 31452702, 31636010, 29288268, 34173806, 30259375, 32519377, 30917906, 34422901, 31692917, 32914551, 34738746, 32343678]

How do CYP1A2 polymorphisms affect the habitual coffee consumption effect on apetite?

The CYP1A2 polymorphism -163C > A (rs762551) polymorphism renders carriers: rapid (AA), intermediate (AC), or slow (CC) caffeine metabolizers. High coffee consumption was more prevalent in rapid compared to slow metabolizers (P = 0.008 after adjustment for age, sex, and BMI) and was associated with lower appetite perception and lower BMI only in rapid metabolizers (P for interaction of rs762551 genotype*coffee consumption = 0.002 and 0.048, respectively).

[34564706]

What is the role of SDE2?

SDE2 is a previously uncharacterized essential gene required for ribosome biogenesis and the regulation of alternative splicing.

[34365507, 33127907]

Which drugs are included in the CABENUVA pill?

Cabenuva contains cabotegravir and rilpivirine. It is used for treatment of HIV.

[33872258, 32495274, 33176247, 32461114, 34408543]

What is Shone's complex?

Shone's syndrome is a rare congenital heart disease that includes 4 cardiovascular anomalies: supravalvular mitral ring, parachute mitral valve, subaortic stenosis, and coarctation of the aorta.

[33032391, 31483300, 33070402, 27456367]

What methods are used to diagnose bowel endometriosis?

Double-contrast barium enema (DCBE), transrectal endoscopic ultrasonography (REU), multidetector computerized tomography enema (MDCT-e), and computed tomography colonoscopy (CTC) have been successfully used for the diagnosis of bowel endometriosis.

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When did FDA approve the first B-cell maturation antigen-targeted CAR-T cell therapy?

FDA approved the first B-cell maturation antigen-targeted CAR-T cell therapy on March 26, 2021.

[32683672, 34549909]

Describe the N6-methyladenosine RNA modification in AML

The N6-methyladenosine RNA modification in AML is a nucleotide that is not normally found in the DNA of cancer cells. This nucleotide has been shown to have an effect on the cell's ability to divide.

[33337619]

Does trimetazidine protect from myocardial injury after percutaneous coronary intervention?

Oral trimetazidine 35 mg twice daily over several years in patients receiving optimal medical therapy, after successful PCI, does not influence the recurrence of angina or the outcome; these findings should be taken into account when considering the place of trimetazidine in clinical practice.

[32877651]

When is the drug Ivermectin used?

Ivermectin (IVM) has been well known for its role in the treatment of parasitic diseases, due to its effect on glutamate-gated chloride channels. These same channels are also present in the mosquito vector, and thus, research has focused on the insecticidal effects of this drug.

[31786697, 31808594, 31758387]

What is the function of a DEAD box protein?

DEAD-box helicases are ubiquitous in RNA-mediated processes and function by coupling cycles of ATP binding and hydrolysis to changes in affinity for single-stranded RNA.

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What is the effect of rHDL-apoE3 on vascular permeability?

rHDL-apoE3 markedly improves vascular permeability as demonstrated by the reduced concentration of Evans Blue dye in tissues such as the stomach, the tongue and the urinary bladder and ameliorated hypercholesterolemia.

[34875308]

What is inhibited by TH1579?

TH1579 is a best-in-class MTH1 inhibitor.

[27827301]

What is the mechanism of action of Gemogenovatucel-T?

Gemogenovatucel-T is an autologous tumour cell vaccine manufactured from harvested tumour tissue, which specifically reduces expression of furin and downstream TGF-β1 and TGF-β2.

[33271095]

What is the Versene Solution used for?

the Versene Solution is used for the detachment of stem cell sheets.

[8266579, 28041835, 29244941]

Are circRNAs susceptible to degradation by RNase R?

Currently, an increasing body of evidence has demonstrated that 1) majority of circRNAs are evolutionarily conserved across species, stable, and resistant to RNase R degradation.

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Does atemoya juice inhibit tye CYP3A4 enzyme?

No, atemoya juice does not inhibit CYP3A4.

[34881402]

Which processes are affected by pathogenic SPTBN1 variants?

SPTBN1 variants lead to effects that affect βII-spectrin stability, disrupt binding to key molecular partners, and disturb cytoskeleton organization and dynamics.

[34211179]

Describe the role of bevacizumab in radiosurgery for arteriovenous malformation.

Bevacizumab is used for the treatment of severe, refractory perilesional edema due to an arteriovenous malformation treated with stereotactic radiosurgery.

[34177536, 22324417, 29198888, 32216590, 27334738, 25360851, 23929592]

Is Mycobacterium abscessus a human pathogen?

Yes, Mycobacterium abscessus is unique in terms of its high morbidity and treatment failure rates.

[32662049, 34460298, 34526902, 34516254]

What is the indication for Favipiravir?

Favipiravir (FVP) has been used for treatment of COVID-19 in many countries.

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Is MEDI2228 a bispecific antibody?

No, MEDI2228 is an antibody drug conjugate (ADC).

[34301753]

Which syndrome is caused by pathogenic COL4A3-COL4A5 variants?

Massively parallel sequencing identifies pathogenic variants in the genes affected in Alport syndrome (COL4A3-COL4A5) in as many as 30% of individuals with focal and segmental glomerulosclerosis (FSGS), 10% of those with kidney failure of unknown cause, and 20% with familial immunoglobulin A (IgA) glomerulonephritis. The population frequencies for Alport syndrome are suggested by the frequencies of predicted pathogenic COL4A3-COL4A5 variants, but must be adjusted for the disease penetrance of individual variants and for the likelihood of already diagnosed disease and non-Gly substitutions.

[34245817, 34400539]

Is proton beam therapy used for treatment of craniopharyngioma?

Yes, proton beam therapy is used for treatment of craniopharyngioma.

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What are the phases of hair follicle cycle?

Hair follicle cycle phases (anagen, catagen and telogen)

[32615938, 32696520, 31415730, 30791955, 31314901]

What is the cause of Bow Hunter's syndrome?

Bow hunter's syndrome (BHS) is caused by posterior circulation insufficiency that results from the occlusion or compression of the vertebral artery (VA) during neck rotation.

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What types of anti-tumor therapeutic antibodies are available?

Anti-tumor therapeutic antibodies include single-targeted antibodies, bi-specific antibodies (BsAbs), and antibody-drug conjugates (ADCs).

[32370812]

Which disease do pathogenic NR2F1 variants cause?

Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS) is an autosomal-dominant disorder characterized by optic atrophy and intellectual disability caused by loss-of-function mutations in NR2F1.

[26986877]

Which mutation is targeted by Tepotinib?

MET Exon 14 Skipping Mutation is targeted by Tepotinib that is used for patients with non-small-cell lung cancer.

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List second messengers.

Cyclic adenosine monophosphate Ceramide Cyclic diguanylate Nitric oxide Calcium Diacylglycerol

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Is there a genetic cause of craniostenosis?

9There a a number of different genetic mutations or syndromes(Saethre-Chotzen, Aperts, Crouzon, Pfeiffer) associated with craniostenosis.

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Can bergapten cross the blood-brain barrier?

Yes, bergapten can cross the blood-brain barrier.

[34347307]

Does TIMELESS-TIPIN participate in replisome disassembly?

Yes. TIMELESS-TIPIN and UBXN-3 promote replisome disassembly during DNA replication termination in Caenorhabditis elegans.

[34269473]

Nemolizumab has been shown to be effective for which disease?

Nemolizumab has been shown to be effective for atopic dermatitis.

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Is hemoglobin antimicrobial?

Yes, Beyond its physiological activity, hemoglobins are able to inhibit the growth of several microorganisms.

[31491713, 32504846, 32050591]

What is the mammalian version of arginine vasotocin?

Arginine vasotocin (AVT) is the non-mammalian homolog of arginine vasopressin (AVP)

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Which kinase does PD98059 inhibit?

PD98059 is a specific, reversible MEK inhibitor.

[32378175]

What is caused by loss-of-function variants in BCAS3?

Bi-allelic loss-of-function variants in BCAS3 cause a syndromic neurodevelopmental disorder. BCAS3 microtubule-associated cell migration factor (BCAS3) is a large, highly conserved cytoskeletal protein previously proposed to be critical in angiogenesis and implicated in human embryogenesis and tumorigenesis.

[34022130]

Which transporter is inhibited by Sotagliflozin?

Sotagliflozin, a dual inhibitor of sodium-glucose co-transporters 1 and 2.

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What is the main use of ETD fragmentation?

Electron-based fragmentation methods have revolutionized biomolecular mass spectrometry, in particular native and top-down protein analysis.

[32070774, 34788003, 33068214, 31999103]

What is the Bartter syndrome?

Bartter syndrome is a rare disorder characterized by reduced sodium chloride transport in the distal nephrons of the kidney. Its clinical features are renal salt wasting, hypokalemic metabolic alkalosis, elevated renin and aldosterone levels with normal or low blood pressure, polyuria, hypercalciuria and malnutrition.

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Can bergapten cause phototoxicity?

Yes, phototoxicity is a side effect of bergapten.

[34347307]

Which syndromes are caused by LAMA1 mutations?

Poretti-Boltshauser and Joubert syndromes

[34249907, 34423300]

What is the use of Lactin-V?

Lactin-V after treatment with vaginal metronidazole resulted in a significantly lower incidence of recurrence of bacterial vaginosis and can be used for bacterial vaginosis. Lactin-V after treatment for cystitis was associated with a reduction in recurrent UTI.

[19543144, 20644497, 21498386, 32402161]

What is Congo red agar plates used for?

Congo red agar plates are used as a canonical indicator of biofilm-formation ability. Culture on Congo red agar plates in which slime-producing strains form black colonies, while nonslime-forming ones develop red colonies.

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What is the protein that is truncated to produce progerin?

The truncated lamin A protein produced "progerin

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What are the effects of ibrutinib on CART cell production?

CART cell generation in the presence of ibrutinib resulted in increased cell viability and expansion of CLL patient-derived CART cells. Furthermore, ibrutinib enriched CART cells with less-differentiated naïve-like phenotype and decreased expression of exhaustion markers including PD-1, TIM-3 and LAG-3. In addition, ibrutinib increased the cytokine release capacity of CLL patient-derived CART cells. In summary, BTK/ITK inhibition with ibrutinib during CART cell culture can improve yield and function of CLL patient-derived CART cell products.

[32683672, 32055000]

What is the role of miR-193b in prostate cancer?

Overexpression of miR-193b led to the inhibition of the majority of the 41 genes in prostate cancer cell lines.

[31225930, 20073067]

What treatment was studied in the KEYNOTE-522 trial?

KEYNOTE-522 trial studied adjuvant pembrolizumab for patients with triple-negative breast cancer.

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Which disease is associated with DNAJB1-PRKACA fusion gene?

Fibrolamellar carcinoma is distinctive at clinical and histologic levels. A novel DNAJB1-PRKACA fusion gene characterizes almost all cases.

[29751881, 32154962, 29222914, 31736218]

What is NTI, Nerve Tissue Contrast Index

The Nerve Tissue Index NTI is a ratio of average brightness levels of surrounding tissue and the median nerve, both calculated on the basis of a ultrasound image.

[31868248]

When was dupilumab approved by EMA?

Dupilumab was approved fby the EMA in 2017.

[31231591]

Describe bigPint

BigPint is a data visualization package available on Bioconductor under the GPL-3 license (https://bioconductor.org/packages/release/bioc/html/bigPint.html). This software introduces new visualization technology that enables independent layers of interactivity using Plotly in R, which aids in the exploration of large biological datasets. The bigPint package presents modernized versions of scatterplot matrices, volcano plots, and litre plots through the implementation of layered interactivity. These graphics have detected normalization issues, differential expression designation problems, and common analysis errors in public RNA-sequencing datasets. Researchers can apply bigPint graphics to their data by following recommended pipelines written in reproducible code in the user manual.

[32542031]

Aducanumab can be used for treatment of which disease?

Aducanumab is approved for treatment of Alzheimer's disease.

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Can IFNg induce the expression of IDO?

Yes, IFNG-induce up-regulation of indoleamine 2,3-dioxygenase (IDO)

[22396896, 30050535, 20811799, 23613752, 34819931]

Covid-19 is though to have arisen from what species?

COVID-19 caused by SARS-CoV-2 most likely originated in bats and transmitted to humans through a possible intermediate host.

[32580969, 34695342, 33457109, 32760632, 32369435, 34329631]

Are TAMs good anticancer therapeutic targets?

Therapeutic strategies to target TAMs to complement conventional therapies has yielded promising results.

[29594035]

Describe meCLICK-Seq

MeCLICK-Seq is a method to identify RNA modification substrates with high resolution at intronic and intergenic regions. The method hijacks RNA methyltransferase activity to introduce an alkyne, instead of a methyl, moiety on RNA.

[33376781]

What is the mechanism of action of Lumasiran?

Lumasiran is a subcutaneously administered small interfering RNA targeting the mRNA for hydroxyacid oxidase 1 gene that is used for the treatment of primary hyperoxaluria type 1 (PH1). By silencing the gene encoding glycolate oxidase, lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of PH1.

[32207686, 33985991, 33513899, 33405070, 33789010, 34022071, 33852222]

Where are Goblet cells localized?

Goblet cells are found in the intestine, in the lungs, in the eyes etc. Goblet cells are localized in the epithelium.

[31922915, 31762020, 31734511, 31782555, 31819932, 31751647]

What is OHRQoL?

The assessment of the oral health-related quality of life (OHRQoL) is possible with the Oral Health Impact Profile-14 (OHIP-14) questionnaire comprising 7 subdomains: functional limitation, physical pain, psychological discomfort, physical disability, psychological disability, social disability, and handicap

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Which VKORC1 genotypes are associated with a need for lower warfarin maintenance dose?

Patients with VKORC1-1639GA or AA required a lower warfarin maintenance dose.

[31673144]

Which R/bioconductor have been developed for copy number analysis?

CNVRanger, seqCNA, iGC, PLRS, SomatiCA, Copynumber, crlmm, KC-SMARTR are all R/bioconductor packages for copy number analysis

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Is gabapentin effective for chronic pelvic pain?

Based on data from multicentre, randomised, double-blind, placebo-controlled trial (GaPP2), treatment with gabapentin did not result in significantly lower pain scores in women with chronic pelvic pain, and was associated with higher rates of side-effects than placebo.

[32979978, 34193515]