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METHODS | In the catgut implantation group , catguts were implanted at Shenshu ( BL 23 ) , Ganshu ( BL 18 ) , Xinshu ( BL 15 ) , Pishu ( BL 20 ) , etc. , once every week . |
METHODS | In the acupuncture group , the conventional acupuncture was applied to the same acupoints as the catgut implantation group , once every two days . |
METHODS | The : treatment of 4 weeks made one session , and continuous 2 sessions were required . |
METHODS | The efficacy was evaluated in , 2 sessions . |
METHODS | The follow-up started in the 12th week . |
METHODS | Before treatment , after treatment and in the follow-up period , Kupperman score and the total score in Hamilton depression scale ( HAMD ) , as well as the factor score were observed in the patients separately . |
RESULTS | Kupperman score , the total HAMD score and the scores in the items of anxiety/somatization , retardation , sleep disorder and cognitive disorder after treatment were all reduced significantly as compared with those before treatment in the two groups ( P < 0.01 , P < 0.05 ) . |
RESULTS | In the follow-up period , the difference in Kupperman was not significant in comparison with that after treatment in the catgut implantation : group ( P > 0.05 ) . |
RESULTS | The total HAMD score and sleep disorder were reduced significantly as compared with those after treatment in the catgut implantation group ( both P < 0.01 ) ; in the acupuncture group , Kupperman score , the total HAMD score and sleep disorder were all increased as compared with those after treatment ( all P < 0.05 ) . |
RESULTS | In ; the catgut implantation group , the total HAMD score was lower than that in the acupuncture group ( P < 0.05 ) , and the scores in the items of retardation and sleep disorder were reduced significantly as compared with those in the acupuncture group ( both P < 0.01 ) . |
CONCLUSIONS | The catgut implantation at back-shu points alleviates perimenopasual sympton is in patients of mild perimenopausal depression of kidney deficiency and liver stagnation syndrome . |
CONCLUSIONS | This therapy effectively relieves depressive disorders by regulating the target symptoms such as anxiety / somatization , retardation , sleep disorder and cognitive ' disorder . |
CONCLUSIONS | The long-term efficacy of this therapy is better than the conventional acupuncture . |
###24952391 | null |
OBJECTIVE | Up to 25 % of patients who undergo a percutaneous coronary intervention show some limitation in the use of drug-eluting stents . |
OBJECTIVE | The aim of this study was to evaluate if titanium-nitride-oxide-coated stents could be a good alternative to everolimus-eluting stents in diabetic patients . |
METHODS | A total of 173 diabetic patients with lesions at moderate risk of restenosis ( exclusion criteria : diameter < 2.5 mm or length > 28 mm in vessels < 3mm , chronic occlusion ) were randomized to a titanium group ( 83 patients ) or an everolimus group ( 90 patients ) . |
RESULTS | Baseline characteristics were well balanced ; 28.3 % of patients were insulin dependent . |
RESULTS | At 1 year , the incidence of major adverse cardiac events ( death , nonfatal myocardial infarction , stroke , or repeat target vessel revascularization ) was significantly higher in the titanium group than in the everolimus group ( total , 14.5 % vs 4.4 % ; P = .02 ; noninsulin-dependent subgroup , 9.7 % vs 3.2 % ; P = .14 ; insulin-dependent subgroup , 28.6 % vs 7.1 % ; P = .04 ) . |
RESULTS | The incidence of death , nonfatal myocardial infarction , stroke , or any revascularization was 16.9 % in the titanium group and 7.8 % in the everolimus group ( P = .06 ) . |
RESULTS | Target lesion and vessel revascularizations occurred in 8.4 % compared with 3.3 % ( P = .15 ) and in 13.3 % compared with 3.3 % ( P = .01 ) in the titanium and everolimus groups , respectively . |
RESULTS | Angiographic follow-up at 9 months showed significantly less late lumen loss in the everolimus group ( in-segment , 0.52 [ standard deviation , 0.58 ) mm vs -0.05 [ 0.32 ] mm ; in-stent , 0.76 [ 0.54 ] mm vs 0.13 [ 0.31 ] mm ; P < .0001 ) . |
CONCLUSIONS | The everolimus-eluting stent is superior to the titanium stent for clinical and angiographic end points in diabetic patients with lesions at moderate risk of restenosis . |
###25516006 | null |
OBJECTIVE | To evaluate the safety of the fixed combination of ibuprofen and famotidine compared with ibuprofen alone from two 24-week , multicenter , double-blind trials designed to evaluate the comparative incidence of endoscopically documented upper gastrointestinal ulcers and a 28-week double-blind extension study . |
METHODS | Safety was analyzed by pooling data from the two double-blind trials and the follow-on study . |
METHODS | Safety was assessed by monitoring the incidence , causality , and severity of adverse events ( AEs ) . |
RESULTS | In the pivotal efficacy and safety trials , discontinuation rates due to any cause and dyspepsia were significantly lower for the ibuprofen/famotidine combination versus ibuprofen alone . |
RESULTS | Other than dyspepsia , gastrointestinal and cardiovascular AEs of special interest were similar . |
RESULTS | Events judged to be treatment related were significantly lower with the ibuprofen/famotidine combination ( 20.6 % vs. 25 % ) . |
RESULTS | In the safety extension population , there were no differences in the discontinuation rates and the reporting of AEs or serious AEs ( SAEs ) between the two groups . |
RESULTS | Gastrointestinal-related events were similar between the groups . |
RESULTS | Incidence of cardiovascular-related AEs of special interest were 11 % ( ibuprofen/famotidine ) and 2 % ( ibuprofen ) ( p = 0.06 ) , possibly due to a higher number of rheumatoid arthritis patients in the combination group . |
RESULTS | Of these , 80 % were reports of hypertension ( 8 % ibuprofen/famotidine vs. 2 % ibuprofen ) . |
RESULTS | Three cases of hypertension in the ibuprofen/famotidine group were considered treatment related . |
RESULTS | The probability of a cardiovascular event decreased during days 112-167 of treatment and remained low with continued treatment . |
CONCLUSIONS | One-year safety data from two pivotal trials and a long-term extension study indicate that the ibuprofen/famotidine combination demonstrates a favorable gastrointestinal safety profile and more patients continued on therapy compared to ibuprofen alone . |
CONCLUSIONS | No new safety signals have been identified . |
CONCLUSIONS | These data offer additional evidence supporting a new therapeutic option to improve gastrointestinal safety and adherence for patients who require long-term ibuprofen . |
###24851689 | null |
OBJECTIVE | To compare the effects of volume-controlled ventilation ( VCV ) and pressure-controlled volume-guaranteed ( PCV-VG ) mode during one-lung ventilation ( OLV ) on circulation , pulmonary function and lung injury . |
METHODS | 2012 February to 2013 March in Ningbo No2 . |
METHODS | Hospital cardiothoracic surgery , 30 patients aged 52 to 76 years ( ASA grade II-III ) undergoing elective thoracoscopic lobectomy were randomly divided into VCV group and PCV-VG group , with 15 cases in each group . |
METHODS | After anesthesia induction and endotracheal intubation , endobronchial blocker was inserted to start OLV . |
METHODS | Heart rate ( HR ) , mean arterial pressure ( MAP ) , measured tidal volume ( TV ) , peak airway pressure ( Ppeak ) , airway resistance ( Raw ) , chest compliance ( Cdyn ) and the end-tidal carbon dioxide pressure ( PetCO ( 2 ) ) were recorded at the time point of 15 minutes after turning to the lateral position , 15 minutes and 60 minutes after OLV , and 15 minutes after the resumption of two lung ventilation . |
METHODS | In the meanwhile , arterial blood gas analysis was conducted to measure indicators of pH , oxygen tension ( PaO ( 2 ) ) and carbon dioxide partial pressure ( PaCO ( 2 ) ) . |
METHODS | Blood was drawn before induction , 1 hour after OLV and 1 hour after the end of surgery , and the concentration of interleukin-6 ( IL-6 ) and tumor necrosis factor-alpha ( TNF - ) were detected by enzyme-linked immunosorbent assay ( ELISA ) . |
RESULTS | HR , MAP , TV , PetCO ( 2 ) , pH and PaCO ( 2 ) in two groups at the time point of 15 minutes after turning to the lateral position , 15 minutes and 60 minutes after OLV , and 15 minutes after the resumption of two lung ventilation showed no significant difference ( P > 0.05 ) . |
RESULTS | At the point of 15 minutes after turning to the lateral position and 15 minutes after two lung ventilation , Ppeak and Cdyn of two groups were significantly different ( P < 0.05 ) ( Ppeak :16 3 cmH ( 2 ) O , 16 3 cmH ( 2 ) O for VCV group and 14 2 cmH ( 2 ) O , 14 2 cmH ( 2 ) O for PCV-VG group ; Cdyn : 43.5 5.9 ml/cmH ( 2 ) O , 43.8 6.7 ml/cmH2O for VCV group and 49.7 7.1 ml/cmH ( 2 ) O , 53.3 9.6 ml/cmH ( 2 ) O for PCV-VG group ) . |
RESULTS | Compared with VCV group , PCV-VG group showed a lower Ppeak 15 minutes and 60 minutes after OLV [ ( 17 2 cmH ( 2 ) O ) vs ( 22 4 cmH ( 2 ) O ) and ( 18 4 cmH ( 2 ) O ) vs ( 23 3 cmH ( 2 ) O ) with a higher Cdyn at the same point ( 38.6 6.3 ml/cmH ( 2 ) O ) vs ( 29.6 3.2 ml/cmH ( 2 ) O ) and 37.3 6.0 ml/cmH ( 2 ) O ) vs ( 30.3 3.8 ml/cmH ( 2 ) O ) ] ( P < 0.01 ) . |
RESULTS | Compared with VCV group,IL-6 and TNF - of PCV-VG group 1 hour after OLV and 1 hour after the end of surgery were significantly lower ( P < 0.01 ) ( IL-6 : 52.32 3.59 vs 62.65 4.17 pg/ml and 63.57 4.98 vs 82.38 4.10 pg/ml ; TNF - : 3.23 0.27 vs 4.19 0.38 pg/ml and 4.01 0.28 vs. 5.49 0.31 pg/ml ) . |
CONCLUSIONS | During one-lung ventilation in thoracoscopic lobectomy , PCV-VG mode has a competitive advantage over VCV mode in terms of pulmonary function and lung protection . |
###24748400 | null |
OBJECTIVE | We compared the recovery profile of propofol and sevoflurane when used for maintenance of anesthesia in elective day care operative procedures . |
METHODS | One hundred ASA physical status I and II patients , aged between 18 and 50 years , were randomly assigned to receive either propofol-nitrous oxide or sevoflurane-nitrous oxide maintenance of anesthesia . |
METHODS | Early and intermediate recovery in terms of cognitive and ambulatory functions was recorded . |
METHODS | Psychomotor testing , in the form of Trieger dot test and digit symbol substitution test , were performed before surgery and in the post-anesthesia care unit at 15 min , 30 min , 1 h , 2 h , and 4 h following nitrous oxide switch-off to evaluate intermediate recovery . |
RESULTS | There were no significant differences in recovery of early cognitive functions between the two groups , except that patients in the sevoflurane group were more responsive at around 10 min following nitrous oxide switch-off and `` recalled address '' earlier than patients in the propofol group . |
RESULTS | There was no significant difference in between the two groups with regard to `` home-readiness . '' |
CONCLUSIONS | Recovery from sevoflurane anesthesia , especially with regard to cognitive functions , may be slightly faster than from propofol , but the difference is not sufficiently significant to affect the time to `` home-readiness '' in patients undergoing day care surgery . |
###24594499 | null |
BACKGROUND | Vertigo imposes considerable health restrictions with significant impact on the patient 's quality of life . |
BACKGROUND | The most effective antivertigo agent is undetermined thus far . |
OBJECTIVE | This study was performed to assess whether promethazine has superior vertigo reduction compared with lorazepam in ED patients . |
METHODS | In this randomized , double-blind , parallel group trial 184 patients were assigned ( 1:1 ratio ) to receive either promethazine , 25 mg intravenously , or lorazepam , 2 mg intravenously . |
METHODS | Primary endpoint was mean change in vertigo intensity at 2 hours measured using visual analog scale ( VAS ) . |
METHODS | Secondary endpoints were mean change in nausea score , need for second dose of study medications , and adverse events ( AEs ) . |
RESULTS | Promethazine was associated with significantly more reduction ( 46.5 mm ) in vertigo than lorazepam ( 25.7 mm , p < 0.001 ) . |
RESULTS | Mean change in nausea score 2 hours after drug injection on the VAS was 28.7 mm for promethazine and 22.8 for lorazepam ( p = 0.002 ) . |
RESULTS | The most frequently reported AEs were lethargy ( 14.1 % in lorazepam group , 4.3 % in promethazine group , p = 0.013 ) and drowsiness ( 10.8 % for promethazine , 2.1 % for lorazepam , p = 0.017 ) . |
CONCLUSIONS | Our study demonstrated the evidence that promethazine is superior to lorazepam in management of peripheral vertigo and vertigo-related nausea in ED adults . |
###24604111 | null |
BACKGROUND | During lower limb lengthening , distraction-induced muscle pain and surrounding joint contractures are frustrating complications for which few effective treatments are available . |
OBJECTIVE | We evaluated Botulinum Toxin Type A ( BtX-A ) injection in the calf muscles during human tibial distraction osteogenesis . |
OBJECTIVE | We hypothesized that it may decrease calf pain and increase ROM of the surrounding joints by reducing muscle stiffness . |
METHODS | Between April 2010 and January 2011 , we evaluated 36 patients undergoing bilateral tibia lengthening who met prespecified inclusion criteria . |
METHODS | All patients underwent stature lengthening with lengthening over a nail or lengthening and then nailing . |
METHODS | BtX-A ( 200IU ) was injected at the calf muscle only in one leg for each patient and the same amount of sterile normal saline was injected into the other leg as a control . |
METHODS | Selection of the leg receiving the toxin was randomized . |
METHODS | Clinical evaluation included a VAS score for calf pain and measurement of ROM of the knees and ankles and calf circumference , with evaluations performed in a double-blinded manner . |
METHODS | Side-to-side differences were analyzed until the end of consolidation phase . |
METHODS | Minimum followup was 24months ( mean , 30months ; range , 24-39months ) . |
METHODS | The distraction rate and the final length gain were similar in the treated and control limbs . |
METHODS | A priori power analysis suggested that 34 legs were required to achieve statistical significance of 0.05 with 80 % of power to detect a 50 % difference in treatment effect between treatment and control groups . |
RESULTS | There were no differences in calf pain , knee and ankle ROM , and maximal calf circumferences between the two legs at each time point . |
CONCLUSIONS | Local injection of 200IU BtX-A at the human calf muscle does not appear to reduce calf pain or help enhance ROM of the knee and ankle during tibial lengthening . |
CONCLUSIONS | However , the small sample size provided sufficient power to detect only relatively large clinical effects ; future , larger trials will be needed to determine whether smaller differences are present . |
METHODS | Level II , therapeutic study . |
METHODS | See Instructions for Authors for a complete description of levels of evidence . |
###25872390 | null |
OBJECTIVE | To assess potential of preoperative therapy with local steroid and non-steroid anti-inflammatory drugs ( SAIDs and NSAIDs ) for prolonging the hypotensive effect of trabeculectomy . |
METHODS | A total of 80 patients with primary open-angle glaucoma planed for trabeculectomy were randomized into 4 groups of 20 each : 3 groups that differed in the studied drug ( nepafenac , dexamethasone , or their non-fixed combination ) and a control group with no preoperative therapy . |
METHODS | The patients instilled 1 drop of either drug b.i.d. for 2 weeks before the surgery and were examined each day of the first week and then at weeks 1 , 2 , 4 and months 3 , 6 , and 12 . |
METHODS | The rate of postoperative surgical and medical interventions ( needling , needling revision , hypotensive therapy ) was used for outcome evaluation . |
RESULTS | Postoperative needling was required in 50 % of the controls , 35 % of the NSAIDs and 30 % of the SAIDs patients as well as 20 % the combination-therapy patients . |
RESULTS | Needling revision had to be performed in 10 % of patients from the control group and 5 % of patients from the NSAIDs group . |
RESULTS | Patients from the steroid and combination-therapy groups had no need in needling procedure . |
RESULTS | Further hypotensive therapy was required in 50 % of the control group , 35 % of the NSAIDs group , 25 % of the SAIDs group and 20 % of the combination-therapy group . |
RESULTS | During the first postoperative year complete success of the treatment was achieved in 50 % of the controls , 65 % of the NSAIDs patients , 75 % of the SAIDs patients , and 80 % of those under combination therapy . |
RESULTS | Qualified success during the same period was achieved in 100 % of cases . |