tokens
sequencelengths 8
579
| ner_tags
sequencelengths 8
579
|
|---|---|
[
"Proteomic",
"analysis",
"of",
"docetaxel",
"resistance",
"in",
"human",
"nasopharyngeal",
"carcinoma",
"cells",
"using",
"the",
"two-dimensional",
"gel",
"electrophoresis",
"method",
"Docetaxel",
"-based",
"chemotherapy",
"has",
"been",
"recommended",
"for",
"advanced",
"nasopharyngeal",
"carcinoma",
"(NPC).",
"However,",
"treatment",
"failure",
"often",
"occurs",
"because",
"of",
"acquired",
"drug",
"resistance.",
"In",
"this",
"study,",
"a",
"docetaxel",
"-",
"resistant",
"NPC",
"cell",
"line",
"CNE-2R",
"was",
"established",
"with",
"increasing",
"doses",
"of",
"docetaxel",
"for",
"more",
"than",
"6",
"months.",
"Two-dimensional",
"gel",
"electrophoresis",
"and",
"ESI-Q-TOF-MS",
"were",
"used",
"to",
"compare",
"the",
"differential",
"expression",
"of",
"docetaxel",
"-",
"resistance",
"-",
"associated",
"proteins",
"between",
"human",
"NPC",
"CNE-2",
"cells",
"and",
"docetaxel",
"-",
"resistant",
"CNE-2R",
"cells.",
"As",
"a",
"result,",
"24",
"differentially",
"expressed",
"proteins",
"were",
"identified,",
"including",
"11",
"proteins",
"with",
"increased",
"expression",
"and",
"13",
"proteins",
"with",
"decreased",
"expression.",
"These",
"proteins",
"function",
"in",
"diverse",
"biological",
"processes",
"such",
"as",
"metabolism,",
"signal",
"transduction,",
"calcium",
"ion",
"binding,",
"immune",
"response,",
"proteolysis,",
"and",
"so",
"on.",
"Among",
"these,",
"α-enolase",
"(ENO1),",
"significantly",
"upregulated",
"in",
"CNE-2R,",
"was",
"selected",
"for",
"detailed",
"analysis.",
"Inhibition",
"of",
"ENO1",
"by",
"shRNA",
"restored",
"CNE-2R",
"cells",
"'",
"sensitivity",
"to",
"docetaxel.",
"Moreover,",
"overexpression",
"of",
"ENO1",
"could",
"facilitate",
"the",
"development",
"of",
"acquired",
"resistance",
"of",
"docetaxel",
"in",
"CNE-2",
"cells.",
"Western",
"blot",
"and",
"reverse-transcription",
"PCR",
"data",
"of",
"clinical",
"samples",
"confirmed",
"that",
"α-enolase",
"was",
"upregulated",
"in",
"docetaxel",
"-",
"resistant",
"human",
"NPC",
"tissues.",
"Finding",
"such",
"proteins",
"might",
"improve",
"interpretation",
"of",
"the",
"molecular",
"mechanisms",
"leading",
"to",
"the",
"acquisition",
"of",
"docetaxel",
"chemoresistance."
] | [
1,
1,
0,
1,
1,
0,
1,
1,
2,
1,
0,
0,
1,
2,
2,
2,
1,
0,
1,
0,
0,
1,
0,
0,
1,
2,
1,
0,
1,
2,
0,
0,
0,
0,
1,
1,
2,
0,
0,
1,
0,
1,
0,
1,
1,
1,
2,
2,
0,
1,
0,
1,
1,
0,
1,
0,
1,
2,
0,
1,
1,
2,
2,
0,
1,
0,
0,
0,
1,
0,
0,
1,
0,
1,
0,
1,
0,
1,
2,
0,
1,
1,
1,
2,
0,
1,
0,
1,
1,
2,
0,
0,
1,
0,
1,
1,
2,
0,
1,
0,
0,
1,
0,
1,
1,
0,
0,
1,
0,
1,
1,
0,
1,
2,
0,
1,
1,
2,
0,
0,
1,
1,
2,
1,
2,
2,
1,
2,
1,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
1,
0,
1,
0,
0,
1,
1,
0,
1,
0,
1,
0,
1,
2,
0,
1,
0,
1,
0,
1,
0,
1,
0,
0,
0,
1,
0,
1,
1,
0,
1,
0,
1,
2,
1,
2,
0,
1,
2,
1,
0,
1,
2,
1,
0,
1,
0,
0,
0,
1,
0,
1,
1,
1,
1,
1,
0,
1,
0,
1,
1,
0,
0,
1,
2,
1,
0,
0,
1,
0,
1,
1
] |
[
"A",
"simple",
"and",
"biosafe",
"method",
"for",
"isolation",
"of",
"human",
"umbilical",
"vein",
"endothelial",
"cells",
"Human",
"umbilical",
"vein",
"endothelial",
"cells",
"(HUVECS)",
"are",
"used",
"as",
"an",
"irreplaceable",
"tool",
"for",
"the",
"study",
"of",
"vascular",
"diseases.",
"However,",
"the",
"technicians",
"who",
"isolate",
"HUVECs",
"are",
"largely",
"exposed",
"to",
"potential",
"infectious",
"threats.",
"Here",
"we",
"report",
"the",
"development",
"of",
"a",
"specialized",
"instrument",
"to",
"protect",
"researchers",
"from",
"known",
"or",
"unknown",
"infectious",
"agents",
"when",
"they",
"operate",
"on",
"human",
"umbilical",
"cords.",
"This",
"instrument",
"can",
"be",
"assembled",
"by",
"common",
"laboratory",
"supplies",
"and",
"adapted",
"to",
"accommodate",
"umbilical",
"cords",
"of",
"different",
"lengths.",
"When",
"the",
"cord",
"is",
"enclosed",
"within",
"the",
"instrument,",
"the",
"risk",
"of",
"sample",
"contamination",
"and",
"operator",
"infection",
"is",
"greatly",
"reduced.",
"Using",
"our",
"instrument,",
"endothelial",
"cells",
"were",
"successfully",
"isolated",
"from",
"human",
"umbilical",
"veins",
"without",
"contamination.",
"The",
"cells",
"were",
"verified",
"by",
"their",
"cobblestone-like",
"morphology",
"and",
"by",
"immunofluorescence",
"staining",
"(Factor",
"VIII",
"and",
"CD31",
"positivity",
"and",
"α-SMA",
"negativity).",
"Our",
"instrument",
"simplifies",
"and",
"optimizes",
"the",
"cell",
"extraction",
"process,",
"and",
"most",
"importantly",
"elevates",
"the",
"biosafety",
"to",
"a",
"higher",
"level",
"during",
"the",
"isolation",
"of",
"human",
"umbilical",
"vein",
"endothelial",
"cells."
] | [
0,
1,
0,
1,
1,
2,
2,
0,
1,
2,
2,
2,
2,
1,
2,
2,
2,
2,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
1,
0,
1,
1,
0,
0,
1,
0,
1,
1,
1,
0,
0,
1,
0,
1,
2,
2,
2,
2,
0,
1,
1,
0,
1,
0,
1,
1,
2,
0,
0,
1,
0,
1,
1,
2,
0,
1,
0,
0,
1,
0,
0,
1,
2,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
0,
1,
0,
0,
0,
0,
1,
0,
1,
0,
1,
1,
0,
1,
1,
0,
0,
1,
0,
0,
1,
1,
2,
0,
0,
0,
0,
1,
1,
2,
0,
1,
0,
1,
0,
0,
0,
0,
1,
2,
0,
0,
1,
2,
1,
2,
0,
1,
2,
0,
1,
2,
0,
1,
0,
0,
0,
0,
1,
1,
2,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
2,
2,
2
] |
[
"Iron",
"Deficiency",
"Is",
"Common",
"During",
"Remission",
"in",
"Children",
"With",
"Inflammatory",
"Bowel",
"Disease",
"The",
"aim",
"was",
"to",
"study",
"prevalence",
"of",
"iron",
"deficiency",
"in",
"children",
"with",
"inflammatory",
"bowel",
"disease",
"(IBD)",
"during",
"remission.",
"In",
"addition,",
"there",
"was",
"an",
"observational",
"evaluation",
"of",
"hematological",
"response",
"to",
"oral",
"iron.",
"A",
"population-based",
"retrospective",
"study",
"including",
"90",
"Swedish",
"children",
"(median",
"13",
"years)",
"with",
"IBD",
"was",
"performed.",
"Patient",
"records",
"covered",
"in",
"median",
"25",
"months.",
"Iron",
"deficiency",
"was",
"present",
"in",
"70/77",
"children",
"(91%)",
"in",
"which",
"iron",
"status",
"could",
"be",
"assessed.",
"In",
"clinical",
"and",
"biochemical",
"remission,",
"iron",
"deficiency",
"was",
"found",
"in",
"57/67",
"(85%)",
"of",
"children,",
"and",
"23",
"(34%)",
"of",
"them",
"had",
"iron",
"deficiency",
"anemia.",
"Thirty-six",
"iron-deficient",
"children",
"were",
"prescribed",
"oral",
"iron",
"supplementation",
"and",
"32",
"(89%)",
"improved",
"hemoglobin",
"levels",
"over",
"6",
"months.",
"In",
"conclusion,",
"iron",
"deficiency",
"is",
"common",
"during",
"clinical",
"remission",
"in",
"children",
"with",
"IBD,",
"even",
"in",
"cohorts",
"with",
"low",
"prevalence",
"of",
"anemia.",
"Therefore,",
"regular",
"biochemical",
"screening",
"for",
"iron",
"deficiency",
"is",
"warranted",
"during",
"all",
"stages",
"of",
"disease,",
"irrespective",
"of",
"symptoms",
"and",
"inflammatory",
"blood",
"markers."
] | [
1,
2,
0,
0,
0,
1,
0,
1,
0,
1,
2,
2,
0,
0,
0,
0,
1,
1,
0,
1,
2,
0,
1,
0,
1,
2,
2,
1,
0,
1,
0,
0,
0,
0,
0,
1,
1,
0,
1,
1,
0,
1,
1,
0,
1,
1,
2,
0,
0,
1,
1,
1,
0,
1,
0,
1,
0,
0,
1,
2,
0,
0,
1,
0,
1,
1,
2,
0,
0,
0,
0,
1,
0,
0,
0,
1,
2,
0,
0,
1,
0,
1,
0,
1,
1,
1,
2,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
1,
0,
1,
1,
1,
2,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
0,
1,
2,
0,
0,
0,
1,
1,
0,
1,
0,
1,
0,
0,
1,
0,
1,
2,
0,
1,
0,
0,
1,
2,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
0,
1,
1,
1
] |
[
"Chemisorption",
"of",
"Perfluorooctanoic",
"Acid",
"on",
"Powdered",
"Activated",
"Carbon",
"Initiated",
"by",
"Persulfate",
"in",
"Aqueous",
"Solution",
"Perfluorooctanoic",
"acid",
"(PFOA)",
"is",
"a",
"perfluorocarboxylic",
"acid",
"that",
"is",
"difficult",
"to",
"treat",
"by",
"most",
"conventional",
"methods.",
"As",
"a",
"result,",
"it",
"is",
"often",
"removed",
"from",
"solution",
"by",
"adsorption",
"on",
"powdered",
"activated",
"carbon",
"(PAC),",
"followed",
"by",
"incineration",
"of",
"the",
"spent",
"carbon.",
"To",
"provide",
"a",
"new",
"approach",
"for",
"treatment,",
"PFOA",
"was",
"exposed",
"to",
"sulfate",
"radicals",
"(SO4(-•))",
"produced",
"by",
"thermolysis",
"of",
"persulfate",
"(S2O8(2-))",
"in",
"the",
"presence",
"of",
"PAC.",
"Under",
"acidic",
"conditions,",
"thermal",
"activation",
"of",
"persulfate",
"resulted",
"in",
"transformation",
"of",
"PFOA",
"to",
"shorter-chain-length",
"perfluorinated",
"compounds,",
"as",
"previously",
"reported.",
"However,",
"when",
"thermolysis",
"of",
"persulfate",
"occurred",
"under",
"circumneutral",
"pH",
"conditions",
"in",
"the",
"presence",
"of",
"PAC,",
"a",
"new",
"removal",
"pathway",
"for",
"PFOA",
"was",
"observed.",
"Under",
"these",
"conditions,",
"the",
"removal",
"of",
"PFOA",
"was",
"attributable",
"to",
"chemisorption,",
"a",
"process",
"in",
"which",
"PAC",
"catalyzed",
"persulfate",
"decomposition",
"and",
"reacted",
"with",
"the",
"transformation",
"products",
"to",
"produce",
"covalently",
"bound",
"PFOA.",
"At",
"PAC",
"concentrations",
"between",
"200",
"and",
"1000",
"mg/L",
"and",
"an",
"initial",
"PFOA",
"concentration",
"of",
"0.5",
"μM,",
"covalent",
"bonding",
"resulted",
"in",
"removal",
"of",
"10-40%",
"of",
"the",
"PFOA.",
"Under",
"these",
"conditions,",
"the",
"process",
"resulted",
"in",
"removal",
"of",
"more",
"than",
"half",
"of",
"a",
"more",
"hydrophilic",
"perfluoroalkyl",
"acid",
"(i.e.,",
"perfluorobutanoic",
"acid,",
"PFBA),",
"which",
"was",
"greater",
"than",
"the",
"amount",
"of",
"PFBA",
"removed",
"by",
"physical",
"adsorption",
"on",
"PAC.",
"Although",
"the",
"high",
"reaction",
"temperatures",
"(i.e.,",
"80",
"°C)",
"and",
"relatively",
"high",
"doses",
"of",
"PAC",
"used",
"in",
"this",
"study",
"may",
"be",
"impractical",
"for",
"drinking",
"water",
"treatment,",
"this",
"process",
"may",
"be",
"applied",
"to",
"the",
"treatment",
"of",
"these",
"recalcitrant",
"compounds",
"in",
"industrial",
"wastewater,",
"reverse",
"osmosis",
"concentrate,",
"and",
"other",
"waters",
"that",
"contain",
"high",
"concentrations",
"of",
"PFOA",
"and",
"other",
"perfluorocarboxylic",
"acids."
] | [
1,
0,
1,
2,
0,
1,
2,
2,
0,
0,
1,
0,
1,
1,
1,
2,
1,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
1,
2,
2,
1,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
1,
2,
1,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
1,
0,
0,
0,
1,
1,
0,
1,
0,
0,
0,
0,
1,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
2,
2,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
1,
0,
0,
0,
0,
1,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
1,
2,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
1,
2,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
1,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
1,
1,
2,
1,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
1,
2
] |
[
"Clinical",
"manifestations,",
"course,",
"and",
"outcome",
"of",
"patients",
"with",
"neutralizing",
"anti-interferon-γ",
"autoantibodies",
"and",
"disseminated",
"nontuberculous",
"mycobacterial",
"infections",
"Neutralizing",
"anti-interferon-γ",
"autoantibody",
"(nAIGA)-associated",
"immunodeficiency",
"is",
"an",
"emerging",
"medical",
"issue",
"worldwide.",
"In",
"the",
"present",
"study,",
"we",
"describe",
"and",
"discuss",
"the",
"clinical",
"features",
"and",
"outcomes",
"of",
"patients",
"with",
"nAIGAs",
"and",
"disseminated",
"infections",
"by",
"nontuberculous",
"mycobacteria",
"(dNTM).We",
"thoroughly",
"reviewed",
"the",
"medical",
"records",
"of",
"all",
"patients.",
"Microorganisms",
"and",
"nAIGAs",
"were",
"identified",
"using",
"previously",
"described",
"methods",
"with",
"modifications.",
"All",
"data",
"were",
"calculated",
"and",
"analyzed",
"using",
"SPSS",
"software",
".Among",
"46",
"adult",
"patients",
"with",
"dNTM",
"infections,",
"we",
"identified",
"45",
"cases",
"(97.8%)",
"with",
"nAIGAs.",
"The",
"average",
"patient",
"age",
"was",
"58.6",
"years,",
"and",
"there",
"was",
"no",
"sex",
"predominance.",
"Cervical",
"lymphadenitis",
"(81.8%)",
"was",
"the",
"most",
"common",
"clinical",
"manifestation.",
"Endocrine",
"disorder",
"was",
"the",
"leading",
"comorbidity",
"(7",
"cases).",
"Malignancies",
"were",
"found",
"in",
"4",
"patients,",
"and",
"all",
"of",
"the",
"malignancies",
"originated",
"from",
"the",
"T-cell",
"/",
"macrophage",
"lineage.",
"More",
"than",
"half",
"of",
"the",
"identifiable",
"isolates",
"were",
"slow-growing",
"NTMs.",
"Twenty-eight",
"(62.2%)",
"and",
"18",
"(40.0%)",
"patients",
"had",
"a",
"history",
"of",
"zoster",
"and",
"salmonellosis,",
"respectively.",
"A",
"high",
"proportion",
"of",
"patients",
"with",
"recurrent",
"episodes",
"of",
"NTM",
"infection",
"or",
"a",
"history",
"of",
"zoster",
"and",
"dNTM",
"infection",
"had",
"initial",
"nAIGA",
"titers",
"≥10",
"dilution",
"(P",
"<",
"0.05).",
"Twenty-seven",
"patients",
"(60.0%)",
"required",
"long-term",
"antimycobacterial",
"therapy",
"and",
"had",
"at",
"least",
"1",
"episode",
"of",
"recurrent",
"NTM",
"disease.",
"No",
"mortality",
"was",
"related",
"to",
"dNTM",
"infection",
".In",
"Taiwan,",
"nAIGAs",
"are",
"a",
"recently",
"recognized",
"mechanism",
"of",
"dNTM",
"infection.",
"Long",
"term",
"of",
"antibiotic",
"treatment",
"and",
"adherence",
"to",
"medical",
"advice",
"are",
"necessary",
"to",
"improve",
"the",
"clinical",
"outcome",
"of",
"patients",
"with",
"nAIGAs."
] | [
1,
1,
1,
0,
1,
2,
2,
0,
1,
2,
2,
0,
1,
1,
2,
1,
1,
2,
2,
1,
1,
0,
0,
0,
1,
2,
1,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
2,
0,
1,
0,
1,
0,
1,
0,
1,
1,
0,
1,
2,
1,
0,
0,
0,
1,
2,
0,
0,
1,
1,
0,
1,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
1,
0,
1,
1,
0,
1,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
1,
1,
1,
2,
0,
0,
0,
0,
0,
1,
1,
1,
2,
0,
0,
0,
1,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
1,
0,
1,
0,
1,
0,
0,
1,
1,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
1,
1,
0,
0,
0,
0,
0,
1,
1,
0,
1,
1,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
1,
2,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
1,
1,
2,
2,
0,
1
] |
[
"STRANGULATION",
"-INDUCED",
"CENTRAL",
"RETINAL",
"ARTERY",
"OCCLUSION:",
"CASE",
"REPORT",
"AND",
"REVIEW",
"OF",
"THE",
"LITERATURE",
"To",
"describe",
"a",
"patient",
"with",
"central",
"retinal",
"artery",
"occlusion",
"following",
"an",
"episode",
"of",
"mechanical",
"strangulation.",
"A",
"retrospective",
"case",
"report.",
"An",
"83-",
"year-old",
"man",
"presented",
"with",
"acute",
"vision",
"loss",
"in",
"his",
"right",
"eye",
"after",
"a",
"strangling",
"episode.",
"Multimodal",
"clinical",
"imaging",
"was",
"performed.",
"Visual",
"acuity",
"in",
"the",
"affected",
"right",
"eye",
"was",
"no",
"light",
"perception.",
"Examination",
"revealed",
"optic",
"nerve",
"edema",
"and",
"optic",
"nerve",
"pallor",
"and",
"also",
"severe",
"vascular",
"attenuation",
"and",
"a",
"cherry-red",
"spot",
"in",
"the",
"macula.",
"Mechanical",
"disruption",
"of",
"carotid",
"plaque",
"can",
"lead",
"to",
"occlusion",
"of",
"the",
"central",
"retinal",
"artery,",
"which",
"may",
"portend",
"a",
"dismal",
"visual",
"prognosis."
] | [
1,
0,
1,
2,
2,
2,
1,
2,
0,
1,
2,
2,
2,
0,
0,
0,
1,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
1,
0,
1,
1,
2,
0,
0,
1,
1,
0,
0,
1,
2,
2,
0,
0,
1,
2,
0,
0,
1,
0,
1,
2,
2,
0,
0,
1,
2,
0,
0,
1,
1,
2,
0,
1,
2,
2,
1,
1,
1,
2,
2,
0,
1,
2,
2,
0,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
1,
1,
2,
0,
1,
2,
0,
0,
0,
1,
2,
2,
2,
2,
2,
0,
0,
0,
0,
1,
1,
1
] |
[
"Glomerulonephritis",
"With",
"Masked",
"Monotypic",
"Immunoglobulin",
"Deposits",
"and",
"Concurrent",
"Lymphomatous",
"Infiltration",
"Kidney",
"injury",
"can",
"be",
"a",
"complication",
"of",
"hematopoietic",
"neoplasia",
"by",
"both",
"direct",
"and",
"indirect",
"mechanisms.",
"Virtually",
"all",
"lymphomas",
"and",
"plasma",
"cell",
"dyscrasias",
"can",
"show",
"kidney",
"involvement,",
"including",
"parenchymal",
"infiltration",
"and",
"by",
"secondary",
"injury.",
"Recently,",
"a",
"unique",
"form",
"of",
"glomerulonephritis",
"with",
"masked",
"monotypic",
"immunoglobulin",
"deposits",
"has",
"been",
"reported,",
"which",
"shows",
"frequent",
"association",
"with",
"hematopoietic",
"neoplasia",
"and",
"a",
"propensity",
"for",
"progressive",
"kidney",
"disease.",
"In",
"many",
"instances,",
"these",
"cases",
"are",
"likely",
"diagnosed",
"as",
"glomerulonephritis",
"with",
"dominant",
"C3",
"due",
"to",
"the",
"absence",
"of",
"immunoglobulin",
"staining",
"by",
"routine",
"immunofluorescence",
"microscopy.",
"The",
"patient",
"reported",
"here",
"showed",
"lymphomatous",
"infiltration",
"on",
"kidney",
"biopsy",
"and",
"mesangial",
"proliferative",
"glomerulonephritis",
"with",
"dominant",
"staining",
"for",
"C3",
"without",
"immunoglobulins",
"on",
"initial",
"immunofluorescence;",
"however,",
"monotypic",
"immunoglobulin",
"G",
"κ",
"light",
"chain",
"was",
"revealed",
"after",
"additional",
"immunofluorescence",
"staining",
"was",
"performed",
"on",
"the",
"paraffin-embedded",
"tissue.",
"This",
"patient's",
"case",
"highlights",
"the",
"evolving",
"state",
"of",
"kidney",
"biopsy",
"interpretation",
"and",
"the",
"expanding",
"spectrum",
"of",
"kidney",
"disease",
"in",
"the",
"setting",
"of",
"hematopoietic",
"neoplasia."
] | [
1,
0,
0,
1,
2,
2,
0,
1,
1,
2,
1,
2,
0,
0,
0,
1,
0,
1,
2,
0,
0,
1,
0,
1,
1,
0,
0,
1,
0,
1,
2,
2,
0,
0,
1,
1,
0,
1,
2,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
1,
2,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
2,
0,
1,
0,
0,
0,
1,
2,
0,
1,
2,
0,
1,
2,
2,
0,
1,
1,
0,
1,
0,
1,
0,
0,
1,
0,
1,
2,
2,
2,
1,
2,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
2,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
2
] |
[
"Does",
"genistein",
"lower",
"plasma",
"lipids",
"and",
"homocysteine",
"levels",
"in",
"postmenopausal",
"women?",
"A",
"meta-analysis",
"To",
"perform",
"a",
"meta-analysis",
"examining",
"the",
"effects",
"of",
"genistein",
"on",
"homocysteine",
"and",
"lipid",
"levels",
"in",
"postmenopausal",
"women.",
"We",
"systematically",
"searched",
"the",
"PubMed,",
"MEDLINE,",
"and",
"Cochrane",
"Library",
"databases",
"and",
"the",
"ClinicalTrials.gov",
"website",
"for",
"studies.",
"We",
"performed",
"a",
"meta-analysis",
"using",
"weighted",
"mean",
"differences",
"(WMD)",
"and",
"95%",
"confidence",
"intervals",
"in",
"a",
"random-effects",
"model.",
"We",
"assessed",
"between-",
"study",
"heterogeneity",
"using",
"the",
"Cochran's",
"Q",
"and",
"I(2)",
"statistics.",
"Eight",
"randomized,",
"controlled",
"trials",
"with",
"a",
"total",
"of",
"476",
"subjects",
"were",
"included",
"in",
"the",
"meta-analysis.",
"Compared",
"with",
"placebos,",
"genistein",
"was",
"effective",
"in",
"reducing",
"plasma",
"levels",
"of",
"homocysteine",
"(WMD,",
"-0.58",
"μmol/l;",
"p",
"=",
"0.001),",
"and",
"increasing",
"high",
"density",
"lipoprotein",
"(HDL)",
"cholesterol",
"levels",
"(WMD,",
"4.9",
"mg/dl;",
"p",
"=",
"0.0002).",
"Subgroup",
"analyses",
"revealed",
"that",
"genistein",
"significantly",
"decreased",
"the",
"levels",
"of",
"low",
"density",
"lipoprotein",
"(LDL)",
"cholesterol",
"(WMD,",
"-16.90",
"mg/dl;",
"p",
"=",
"0.01),",
"total",
"cholesterol",
"(WMD,",
"-15.83",
"mg/dl;",
"p",
"=",
"0.008),",
"and",
"triglycerides",
"(WMD,",
"-46.58",
"mg/dl;",
"p",
"=",
"0.03)",
"in",
"postmenopausal",
"women",
"with",
"metabolic",
"syndrome,",
"but",
"had",
"no",
"significant",
"effects",
"in",
"those",
"with",
"no",
"metabolic",
"syndrome.",
"Our",
"meta-analysis",
"demonstrates",
"that",
"genistein",
"significantly",
"reduces",
"homocysteine",
"levels",
"and",
"increases",
"HDL",
"cholesterol",
"levels",
"in",
"postmenopausal",
"women.",
"Genistein",
"also",
"significantly",
"decreases",
"LDL",
"cholesterol,",
"total",
"cholesterol",
"and",
"triglyceride",
"levels",
"in",
"postmenopausal",
"women",
"with",
"metabolic",
"syndrome."
] | [
0,
1,
0,
1,
2,
0,
1,
2,
0,
1,
1,
0,
1,
0,
1,
0,
1,
1,
0,
1,
0,
1,
0,
0,
0,
1,
2,
0,
1,
1,
0,
1,
2,
0,
1,
1,
0,
1,
2,
2,
0,
0,
1,
2,
0,
1,
0,
0,
0,
1,
0,
1,
2,
2,
1,
0,
0,
1,
2,
0,
0,
1,
2,
0,
1,
0,
1,
1,
0,
0,
1,
2,
0,
1,
2,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
1,
0,
1,
0,
0,
1,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
1,
2,
0,
1,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
0,
0,
0,
0,
1,
2,
2,
1,
2,
1,
0,
0,
0,
0,
0,
1,
2,
1,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
1,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
0,
0,
1,
0,
0,
1,
2,
0,
0,
1,
2,
2,
0,
1,
1,
1,
0,
0,
0,
1,
2,
1,
2,
0,
1,
2,
0,
1,
1,
0,
1,
2
] |
[
"Neonatal",
"Heart",
"-Enriched",
"miR-708",
"Promotes",
"Differentiation",
"of",
"Cardiac",
"Progenitor",
"Cells",
"in",
"Rats",
"Cardiovascular",
"disease",
"is",
"becoming",
"the",
"leading",
"cause",
"of",
"death",
"throughout",
"the",
"world.",
"However,",
"adult",
"hearts",
"have",
"limited",
"potential",
"for",
"regeneration",
"after",
"pathological",
"injury,",
"partly",
"due",
"to",
"the",
"quiescent",
"status",
"of",
"stem",
"/",
"progenitor",
"cells.",
"Reactivation",
"of",
"cardiac",
"stem",
"/",
"progenitor",
"cells",
"to",
"create",
"more",
"myocyte",
"progeny",
"is",
"one",
"of",
"the",
"key",
"steps",
"in",
"the",
"regeneration",
"of",
"a",
"damaged",
"heart.",
"In",
"this",
"study,",
"miR-708",
"was",
"identified",
"to",
"be",
"enriched",
"in",
"the",
"neonatal",
"cardiomyocytes",
"of",
"rats,",
"but",
"this",
"has",
"not",
"yet",
"been",
"proven",
"in",
"adult",
"humans.",
"A",
"lower",
"level",
"of",
"miR-708",
"in",
"c-kit(+)",
"stem",
"/",
"progenitor",
"cells",
"was",
"detected",
"compared",
"to",
"non-progenitors.",
"Overexpression",
"of",
"miR-708",
"induced",
"cardiomyocyte",
"differentiation",
"of",
"cardiac",
"stem",
"/",
"progenitor",
"cells.",
"This",
"finding",
"strengthened",
"the",
"potential",
"of",
"applying",
"miRNAs",
"in",
"the",
"regeneration",
"of",
"injured",
"hearts,",
"and",
"this",
"indicates",
"that",
"miR-708",
"could",
"be",
"a",
"novel",
"candidate",
"for",
"treatment",
"of",
"heart",
"diseases."
] | [
1,
2,
0,
1,
0,
1,
0,
1,
2,
2,
0,
1,
1,
2,
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
1,
0,
1,
2,
0,
1,
2,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
1,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
1,
0,
1,
1,
0,
1,
2,
0,
0,
0,
0,
1,
1,
0,
1,
0,
1,
0,
0,
1,
2,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2
] |
[
"Coarse",
"Fraction",
"Particle",
"Matter",
"and",
"Exhaled",
"Nitric",
"Oxide",
"in",
"Non",
"-",
"Asthmatic",
"Children",
"Coarse",
"particle",
"matter,",
"PMcoarse,",
"is",
"associated",
"with",
"increased",
"respiratory",
"morbidity",
"and",
"mortality.",
"The",
"aim",
"of",
"this",
"study",
"was",
"to",
"investigate",
"the",
"association",
"between",
"short-term",
"changes",
"in",
"PMcoarse",
"and",
"sub-clininal",
"airway",
"inflammation",
"in",
"children.",
"Healthy",
"children",
"aged",
"11",
"years",
"from",
"two",
"northern",
"Swedish",
"elementary",
"schools",
"underwent",
"fraction",
"of",
"exhaled",
"nitrogen",
"oxide",
"(FENO)",
"measurements",
"to",
"determine",
"levels",
"of",
"airway",
"inflammation",
"twice",
"weekly",
"during",
"the",
"study",
"period",
"from",
"11",
"April-6",
"June",
"2011.",
"Daily",
"exposure",
"to",
"PMcoarse,",
"PM2.5,",
"NO₂,",
"NOx,",
"NO",
"and",
"O₃",
"and",
"birch",
"pollen",
"was",
"estimated.",
"Multiple",
"linear",
"regression",
"was",
"used.",
"Personal",
"covariates",
"were",
"included",
"as",
"fixed",
"effects",
"and",
"subjects",
"were",
"included",
"as",
"a",
"random",
"effect.",
"In",
"total,",
"95",
"children",
"participated",
"in",
"the",
"study,",
"and",
"in",
"all",
"493",
"FENO",
"measurements",
"were",
"made.",
"The",
"mean",
"level",
"of",
"PMcoarse",
"was",
"16.1",
"μg/m³",
"(range",
"4.1-42.3),",
"and",
"that",
"of",
"O₃",
"was",
"75.0",
"μg/m³",
"(range:",
"51.3-106.3).",
"That",
"of",
"NO₂",
"was",
"17.0",
"μg/m³",
"(range:",
"4.7-31.3),",
"NOx",
"was",
"82.1",
"μg/m³",
"(range:",
"13.3-165.3),",
"and",
"NO",
"was",
"65",
"μg/m³",
"(range:",
"8.7-138.4)",
"during",
"the",
"study",
"period.",
"In",
"multi-pollutant",
"models",
"an",
"interquartile",
"range",
"increase",
"in",
"24",
"h",
"PMcoarse",
"was",
"associated",
"with",
"increases",
"in",
"FENO",
"by",
"between",
"6.9",
"ppb",
"(95%",
"confidence",
"interval",
"0.0-14)",
"and",
"7.3",
"ppb",
"(95%",
"confidence",
"interval",
"0.4-14.9).",
"PMcoarse",
"was",
"associated",
"with",
"an",
"increase",
"in",
"FENO,",
"indicating",
"sub-clinical",
"airway",
"inflammation",
"in",
"healthy",
"children."
] | [
1,
1,
1,
2,
0,
1,
1,
2,
0,
1,
0,
1,
1,
1,
1,
2,
1,
0,
0,
0,
1,
1,
2,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
1,
0,
1,
0,
1,
1,
1,
0,
1,
1,
2,
1,
0,
1,
0,
0,
1,
2,
1,
2,
0,
1,
2,
1,
1,
2,
1,
1,
0,
0,
1,
0,
1,
1,
0,
1,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
1,
2,
1,
1,
1,
1,
0,
0,
1,
0,
1,
2,
0,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
1,
2,
0,
1,
0,
0,
0,
0,
1,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
0,
1,
1,
0,
0,
0,
1,
1,
0,
1,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
0,
1,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
1,
1,
0,
1,
1,
0,
1,
2,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
2,
0,
1,
0,
0,
0,
0,
1,
0,
1,
0,
1,
1,
1,
0,
1,
2
] |
[
"NLRC5",
"promotes",
"cell",
"proliferation",
"via",
"regulating",
"the",
"AKT",
"/",
"VEGF-A",
"signaling",
"pathway",
"in",
"hepatocellular",
"carcinoma",
"NLRC5,",
"a",
"newly",
"found",
"member",
"of",
"the",
"NLR",
"family",
"and",
"the",
"largest",
"member",
"of",
"nucleotide-binding,",
"has",
"been",
"reported",
"to",
"regulate",
"immune",
"responses",
"and",
"is",
"associated",
"with",
"hepatocellular",
"carcinoma",
"(HCC).",
"We",
"investigated",
"the",
"mechanisms",
"and",
"signaling",
"pathways",
"of",
"NLRC5",
"in",
"HCC",
"progression.",
"Increased",
"expression",
"of",
"NLRC5,",
"vascular",
"endothelial",
"growth",
"factor-A",
"(VEGF-A)",
"were",
"found",
"in",
"human",
"HCC",
"tissue.",
"There",
"was",
"a",
"positive",
"correlation",
"between",
"NLRC5",
"and",
"VEGF-A",
"expression",
"and",
"cell",
"proliferation",
"were",
"enhanced",
"in",
"NLRC5",
"-",
"overexpressing",
"HepG2",
"cells,",
"but",
"inhibited",
"in",
"cells",
"with",
"NLRC5",
"silencing",
"treatment.",
"Interestingly,",
"we",
"found",
"that",
"up-regulation",
"of",
"NLRC5",
"also",
"coordinated",
"the",
"activation",
"of",
"PI3K/AKT",
"signaling",
"pathway.",
"An",
"AKT",
"inhibitor",
"LY294002",
"blocked",
"VEGF-A",
"expression",
"and",
"AKT",
"phosphorylation",
"in",
"HepG2",
"cells",
"and",
"NLRC5",
"-",
"overexpressing",
"HepG2",
"cells.",
"These",
"results",
"demonstrate",
"that",
"NLRC5",
"promotes",
"HCC",
"progression",
"via",
"the",
"AKT",
"/",
"VEGF-A",
"signaling",
"pathway."
] | [
1,
1,
1,
2,
0,
0,
0,
1,
0,
1,
2,
2,
0,
1,
2,
1,
0,
1,
0,
1,
0,
0,
1,
2,
0,
0,
1,
1,
0,
1,
0,
0,
1,
0,
1,
1,
2,
0,
0,
1,
2,
1,
2,
1,
0,
1,
0,
1,
0,
1,
2,
0,
1,
0,
1,
1,
1,
1,
0,
1,
1,
2,
2,
2,
1,
0,
0,
0,
1,
1,
1,
0,
0,
0,
1,
1,
0,
1,
0,
1,
1,
0,
1,
2,
0,
1,
0,
1,
0,
1,
1,
2,
0,
1,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
1,
0,
1,
0,
1,
0,
1,
0,
1,
2,
2,
0,
1,
2,
2,
1,
1,
1,
0,
1,
1,
0,
1,
2,
0,
1,
0,
1,
1,
2,
0,
1,
0,
0,
1,
1,
1,
1,
0,
0,
1,
0,
1,
2,
2
] |
[
"Community",
"Design",
"Impacts",
"on",
"Health",
"Habits",
"in",
"Low-income",
"Southern",
"Nevadans",
"The",
"purposes",
"of",
"this",
"exploratory",
"study",
"were",
"to:",
"(1)",
"characterize",
"selected",
"community",
"design",
"features;",
"and",
"(2)",
"determine",
"the",
"relationship",
"between",
"select",
"features",
"and",
"physical",
"activity",
"(PA)",
"levels",
"and",
"nutrition",
"habits",
"for",
"a",
"small",
"sample",
"of",
"low-income",
"southern",
"Nevadans.",
"Secondary",
"analysis",
"was",
"conducted",
"on",
"data",
"from",
"selected",
"participants",
"of",
"the",
"Nevada",
"Healthy",
"Homes",
"Partnership",
"program;",
"self-report",
"data",
"on",
"PA",
"and",
"diet",
"habits",
"were",
"compared",
"to",
"national",
"guidelines.",
"Community",
"design",
"features",
"were",
"identified",
"via",
"GIS",
"within",
"a",
"one-mile",
"radius",
"of",
"participants",
"'",
"homes.",
"Descriptive",
"statistics",
"characterized",
"these",
"features",
"and",
"chi-square",
"analyses",
"were",
"conducted",
"to",
"determine",
"the",
"relationship",
"between",
"select",
"features",
"and",
"habits.",
"Data",
"from",
"71",
"participants",
"were",
"analyzed;",
"the",
"majority",
"failed",
"to",
"reach",
"either",
"PA",
"or",
"fruit",
"and",
"vegetable",
"guidelines",
"(81.7%",
"and",
"93.0%,",
"respectively).",
"Many",
"neighborhoods",
"were",
"absent",
"of",
"parks",
"(71.8%),",
"trailheads",
"(36.6%),",
"or",
"pay-for-use",
"PA",
"facilities",
"(47.9%).",
"The",
"mean",
"number",
"of",
"grocery",
"stores",
"was",
"3.4",
"±",
"2.3",
"per",
"neighborhood.",
"Chi-square",
"analyses",
"were",
"not",
"statistically",
"significant.",
"Findings",
"were",
"insufficient",
"to",
"make",
"meaningful",
"conclusions,",
"but",
"support",
"the",
"need",
"for",
"health",
"promotion",
"to",
"meet",
"guidelines.",
"More",
"research",
"is",
"needed",
"to",
"assess",
"the",
"impact",
"of",
"health-promoting",
"community",
"design",
"and",
"healthy",
"behaviors,",
"particularly",
"in",
"vulnerable",
"populations."
] | [
1,
1,
1,
0,
1,
2,
0,
1,
1,
2,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
1,
1,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
2,
1,
1,
0,
1,
2,
0,
0,
0,
0,
0,
1,
1,
2,
1,
2,
0,
0,
0,
1,
0,
0,
1,
0,
0,
1,
2,
2,
2,
2,
1,
1,
0,
1,
0,
1,
2,
0,
1,
0,
1,
2,
1,
1,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
1,
1,
2,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
1,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
1,
2,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
1,
1,
0,
1,
2,
0,
0,
1,
2
] |
[
"Identification",
"of",
"yeasts",
"isolated",
"from",
"raffia",
"wine",
"(Raphia",
"hookeri)",
"produced",
"in",
"Côte",
"d'Ivoire",
"and",
"genotyping",
"of",
"Saccharomyces",
"cerevisiae",
"strains",
"by",
"PCR",
"inter-delta",
"Raffia",
"wine",
"is",
"a",
"traditional",
"alcoholic",
"beverage",
"produced",
"in",
"several",
"African",
"countries",
"where",
"it",
"plays",
"a",
"significant",
"role",
"in",
"traditional",
"customs",
"and",
"population",
"diet.",
"Alcoholic",
"fermentation",
"of",
"this",
"beverage",
"is",
"ensured",
"by",
"a",
"complex",
"natural",
"yeast",
"flora",
"which",
"plays",
"a",
"decisive",
"role",
"in",
"the",
"quality",
"of",
"the",
"final",
"product.",
"This",
"present",
"study",
"aims",
"to",
"evaluate",
"the",
"distribution",
"and",
"the",
"diversity",
"of",
"the",
"yeast",
"strains",
"isolated",
"in",
"raffia",
"wine",
"from",
"four",
"sampling",
"areas",
"(Abengourou,",
"Alépé,",
"Grand-Lahou",
"and",
"Adzopé)",
"in",
"Côte",
"d'Ivoire.",
"Based",
"on",
"the",
"D1/D2",
"domain",
"of",
"the",
"LSU",
"rDNA",
"sequence",
"analysis,",
"nine",
"species",
"belonging",
"to",
"six",
"genera",
"were",
"distinguished.",
"With",
"a",
"percentage",
"of",
"69.5",
"%",
"out",
"of",
"171",
"yeast",
"isolates,",
"Saccharomyces",
"cerevisiae",
"was",
"the",
"predominant",
"species",
"in",
"the",
"raffia",
"wine,",
"followed",
"by",
"Kodamaea",
"ohmeri",
"(20.4",
"%).",
"The",
"other",
"species",
"isolated",
"were",
"Candida",
"haemulonii",
"(4.1",
"%),",
"Candida",
"phangngensis",
"(1.8",
"%),",
"Pichia",
"kudriavzevii",
"(1.2",
"%),",
"Hanseniaspora",
"jakobsenii",
"(1.2",
"%),",
"Candida",
"silvae",
"(0.6",
"%),",
"Hanseniaspora",
"guilliermondii",
"(0.6",
"%)",
"and",
"Meyerozyma",
"caribbica",
"(0.6",
"%).",
"The",
"molecular",
"characterization",
"of",
"S.",
"cerevisiae",
"isolates",
"at",
"the",
"strain",
"level",
"using",
"the",
"PCR-interdelta",
"method",
"revealed",
"the",
"presence",
"of",
"21",
"profiles",
"(named",
"I",
"to",
"XXI)",
"within",
"115",
"isolates.",
"Only",
"four",
"profiles",
"(I,",
"III,",
"V",
"and",
"XI)",
"were",
"shared",
"by",
"the",
"four",
"areas",
"under",
"study.",
"Phenotypic",
"characterization",
"of",
"K.",
"ohmeri",
"strains",
"showed",
"two",
"subgroups",
"for",
"sugar",
"fermentation",
"and",
"no",
"diversity",
"for",
"the",
"nitrogen",
"compound",
"assimilations",
"and",
"the",
"growth",
"at",
"different",
"temperatures."
] | [
1,
0,
1,
1,
0,
1,
2,
1,
2,
0,
0,
1,
2,
0,
1,
0,
1,
2,
1,
0,
1,
2,
1,
2,
0,
0,
1,
1,
2,
0,
0,
1,
1,
2,
0,
0,
0,
0,
1,
1,
0,
1,
1,
0,
1,
1,
1,
2,
0,
0,
1,
0,
0,
0,
0,
1,
1,
1,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
1,
1,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
1,
1,
1,
0,
1,
2,
0,
0,
1,
1,
1,
1,
1,
0,
1,
0,
1,
2,
0,
0,
0,
1,
2,
0,
0,
1,
2,
2,
2,
1,
1,
0,
0,
1,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
1,
1,
2,
0,
0,
1,
1,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
0,
1,
1,
0,
1,
2,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
1,
2,
0,
0,
0,
1,
1,
0,
1,
2,
1,
0,
0,
1,
1,
0,
0,
1,
1,
0,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
1,
1,
2,
0,
1,
2,
1,
0,
1,
1,
0,
1,
2,
0,
0,
1,
0,
0,
1,
2,
1,
0,
0,
1,
0,
1,
1
] |
[
"Inducement",
"of",
"tissue",
"regeneration",
"of",
"harvested",
"hamstring",
"tendons",
"in",
"a",
"rabbit",
"model",
"The",
"objective",
"of",
"this",
"study",
"was",
"to",
"determine",
"if",
"the",
"use",
"of",
"fascia",
"lata",
"as",
"a",
"tendon",
"regeneration",
"guide",
"(placed",
"into",
"the",
"tendon",
"canal",
"following",
"harvesting",
"the",
"semitendinosus",
"tendon)",
"would",
"improve",
"the",
"incidence",
"of",
"tissue",
"regeneration",
"and",
"prevent",
"fatty",
"degeneration",
"of",
"the",
"semitendinosus",
"muscle.",
"Bilateral",
"semitendinosus",
"tendons",
"were",
"harvested",
"from",
"rabbits",
"using",
"a",
"tendon",
"stripper.",
"On",
"the",
"inducing",
"graft",
"(IG)",
"side,",
"the",
"tendon",
"canal",
"and",
"semitendinosus",
"tibial",
"attachment",
"site",
"were",
"connected",
"by",
"the",
"fascia",
"lata,",
"which",
"was",
"harvested",
"at",
"the",
"same",
"width",
"as",
"the",
"semitendinosus",
"tendon.",
"On",
"the",
"control",
"side,",
"no",
"special",
"procedures",
"were",
"performed.",
"Two",
"groups",
"of",
"six",
"rabbits",
"were",
"killed",
"at",
"post-operative",
"weeks",
"4",
"and",
"8,",
"respectively.",
"In",
"addition,",
"three",
"healthy",
"rabbits",
"were",
"killed",
"to",
"obtain",
"normal",
"tissue.",
"We",
"evaluated",
"the",
"incidence",
"of",
"tendon",
"tissue",
"regeneration,",
"cross-sectional",
"area",
"of",
"the",
"regenerated",
"tendon",
"tissue",
"and",
"proportion",
"of",
"fatty",
"tissue",
"in",
"the",
"semitendinosus",
"muscle.",
"At",
"post-operative",
"week",
"8,",
"the",
"distal",
"end",
"of",
"the",
"regenerated",
"tissue",
"reached",
"the",
"vicinity",
"of",
"the",
"tibial",
"insertion",
"on",
"the",
"control",
"side",
"in",
"two",
"of",
"six",
"specimens.",
"On",
"the",
"IG",
"side,",
"the",
"regenerated",
"tissue",
"maintained",
"continuity",
"with",
"the",
"tibial",
"insertion",
"in",
"all",
"specimens.",
"The",
"cross-sectional",
"area",
"of",
"the",
"IG",
"side",
"was",
"significantly",
"greater",
"than",
"that",
"of",
"the",
"control",
"side.",
"The",
"proportion",
"of",
"fatty",
"tissue",
"in",
"the",
"semitendinosus",
"muscle",
"on",
"the",
"IG",
"side",
"was",
"comparable",
"with",
"that",
"of",
"the",
"control",
"side,",
"but",
"was",
"significantly",
"greater",
"than",
"that",
"of",
"the",
"normal",
"muscle.",
"Tendon",
"tissue",
"regenerated",
"with",
"the",
"fascia",
"lata",
"graft",
"was",
"thicker",
"than",
"naturally",
"occurring",
"regenerated",
"tissue.",
"However,",
"the",
"proportion",
"of",
"fatty",
"tissue",
"in",
"the",
"semitendinosus",
"muscle",
"was",
"greater",
"than",
"that",
"of",
"normal",
"muscle",
".Cite",
"this",
"article:",
"K.",
"Tabuchi,",
"T.",
"Soejima,",
"H.",
"Murakami,",
"K.",
"Noguchi,",
"N.",
"Shiba,",
"K.",
"Nagata.",
"Inducement",
"of",
"tissue",
"regeneration",
"of",
"harvested",
"hamstring",
"tendons",
"in",
"a",
"rabbit",
"model.",
"Bone",
"Joint",
"Res",
"2016;5:247-252.",
"DOI:",
"10.1302/2046-3758.56.2000585."
] | [
1,
0,
1,
2,
0,
1,
1,
2,
0,
0,
1,
1,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
1,
2,
1,
2,
0,
0,
1,
1,
0,
0,
0,
0,
1,
2,
0,
1,
0,
1,
2,
0,
1,
0,
1,
0,
1,
2,
0,
1,
1,
2,
0,
0,
1,
2,
1,
1,
2,
0,
1,
0,
1,
0,
0,
1,
2,
0,
0,
1,
1,
1,
1,
0,
1,
2,
0,
1,
1,
1,
2,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
0,
0,
1,
0,
0,
1,
2,
0,
0,
1,
1,
0,
0,
1,
0,
1,
0,
1,
0,
0,
1,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
1,
0,
1,
1,
2,
0,
0,
0,
1,
0,
1,
1,
2,
1,
1,
0,
0,
1,
1,
2,
0,
1,
0,
1,
2,
0,
0,
1,
2,
0,
1,
1,
0,
0,
1,
2,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
1,
0,
0,
1,
1,
0,
0,
0,
0,
1,
0,
0,
1,
2,
0,
1,
1,
0,
1,
0,
0,
1,
1,
0,
0,
1,
0,
1,
1,
0,
0,
1,
2,
0,
0,
1,
0,
0,
0,
0,
1,
1,
0,
1,
0,
1,
2,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
1,
0,
0,
0,
0,
1,
2,
1,
2,
1,
0,
0,
1,
2,
1,
0,
1,
0,
0,
0,
1,
1,
0,
0,
1,
0,
1,
2,
0,
0,
1,
2,
0,
1,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
1,
1,
2,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0
] |
[
"Immediate",
"and",
"Delayed",
"Effects",
"of",
"Diode",
"Laser",
"on",
"Debonding",
"of",
"Ceramic",
"Brackets:",
"An",
"in",
"vitro",
"Study",
"The",
"aim",
"of",
"the",
"study",
"is",
"to",
"evaluate",
"the",
"immediate",
"and",
"delayed",
"effects",
"of",
"diode",
"laser",
"on",
"debonding",
"of",
"ceramic",
"brackets.",
"A",
"total",
"of",
"60",
"human",
"extracted",
"premolar",
"teeth",
"were",
"randomly",
"assigned",
"to",
"three",
"different",
"treatment",
"groups.",
"All",
"teeth",
"were",
"bonded",
"with",
"adhesive",
"precoated",
"(APC)",
"ceramic",
"brackets",
"(3M",
"Unitek).",
"A",
"total",
"of",
"20",
"teeth",
"were",
"debonded",
"without",
"lasing",
"(group",
"1),",
"20",
"immediately",
"after",
"lasing",
"(group",
"2),",
"and",
"20",
"1",
"hour",
"after",
"lasing",
"(group",
"3).",
"For",
"the",
"lasing",
"groups",
"(groups",
"2",
"and",
"3),",
"access",
"cavity",
"was",
"prepared",
"on",
"the",
"occlusal",
"surface",
"to",
"a",
"2",
"mm",
"diameter.",
"A",
"transbond",
"plus",
"self-etching",
"primer",
"(3M",
"Unitek,",
"Monrovia,",
"CA,",
"USA)",
"and",
"APC",
"PLUS",
"clarity",
"advanced",
"brackets",
"(3M,",
"Unitek,",
"Monrovia,",
"CA,",
"USA)",
"were",
"used.",
"The",
"shear",
"bond",
"strength",
"(SBS)",
"and",
"adhesive",
"remnant",
"index",
"(ARI)",
"were",
"measured.",
"The",
"internal",
"pulpal",
"wall",
"temperature",
"was",
"noted",
"for",
"the",
"laser",
"groups.",
"The",
"mean",
"SBS",
"was",
"15.4,",
"11.57,",
"and",
"11.79",
"MPa",
"for",
"groups",
"1",
"to",
"3",
"respectively.",
"Post",
"hoc",
"test",
"showed",
"significant",
"difference",
"(p",
"<",
"0.001)",
"between",
"the",
"control",
"group",
"and",
"the",
"lased",
"groups.",
"For",
"groups",
"2",
"and",
"3,",
"the",
"rise",
"in",
"temperature",
"was",
"at",
"an",
"average",
"of",
"1.4",
"and",
"1.3°C",
"respectively.",
"The",
"SBS",
"of",
"APC",
"brackets",
"decreased",
"by",
"33.3%",
"on",
"application",
"of",
"diode",
"laser",
"without",
"increasing",
"the",
"internal",
"pulp",
"chamber",
"wall",
"temperature",
"significantly.",
"Shear",
"bond",
"strength",
"remains",
"more",
"or",
"less",
"the",
"same",
"whether",
"debonding",
"is",
"done",
"immediately",
"after",
"lasing",
"or",
"1",
"hour",
"after",
"lasing.",
"Diode",
"lasers",
"increased",
"the",
"ARI",
"scores",
"and",
"thus",
"decreased",
"the",
"risk",
"of",
"enamel",
"fracture."
] | [
1,
0,
1,
1,
2,
1,
2,
0,
1,
0,
1,
2,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
1,
1,
2,
1,
2,
0,
1,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
2,
0,
1,
2,
0,
0,
0,
1,
1,
0,
1,
0,
1,
2,
1,
2,
1,
1,
2,
1,
2,
0,
0,
0,
0,
1,
0,
1,
0,
1,
1,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
1,
1,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
1,
2,
1,
1,
1,
0,
1,
2,
1,
2,
2,
1,
2,
1,
1,
1,
0,
0,
0,
1,
2,
2,
1,
0,
1,
2,
2,
2,
0,
0,
0,
1,
1,
2,
1,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
2,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
1,
2,
2,
1,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
0,
0,
0,
0,
1,
1,
2,
0,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
2
] |
[
"The",
"number",
"of",
"tumorspheres",
"cultured",
"from",
"peripheral",
"blood",
"is",
"a",
"predictor",
"for",
"presence",
"of",
"metastasis",
"in",
"patients",
"with",
"breast",
"cancer",
"Tumor",
"metastases",
"are",
"the",
"major",
"cause",
"of",
"cancer",
"morbidity",
"and",
"mortality.",
"A",
"subpopulation",
"of",
"tumor",
"cells",
"with",
"stem-like",
"properties",
"is",
"assumed",
"to",
"be",
"responsible",
"for",
"tumor",
"invasion,",
"metastasis,",
"heterogeneity",
"and",
"therapeutic",
"resistance.",
"This",
"population",
"is",
"termed",
"cancer",
"stem",
"cells",
"(CSCs).",
"We",
"have",
"developed",
"a",
"simple",
"method",
"for",
"identification",
"and",
"characterization",
"of",
"circulating",
"cancer",
"stem",
"cells",
"among",
"circulating",
"epithelial",
"tumor",
"cells",
"(CETCs).",
"CETCs",
"were",
"cultured",
"under",
"conditions",
"favoring",
"growth",
"of",
"tumorspheres",
"from",
"72",
"patients",
"with",
"breast",
"cancer,",
"including",
"a",
"subpopulation",
"of",
"23",
"patients",
"with",
"metastatic",
"disease.",
"CETCs",
"were",
"determined",
"using",
"the",
"maintrac®",
"method.",
"Gene",
"expression",
"profiles",
"of",
"single",
"CETCs",
"and",
"tumorspheres",
"of",
"the",
"same",
"patients",
"were",
"analyzed",
"using",
"qRT-PCR.",
"Sphere",
"formation",
"was",
"observed",
"in",
"79",
"%",
"of",
"patients.",
"We",
"found",
"that",
"the",
"number",
"of",
"tumorspheres",
"depended",
"on",
"stage",
"of",
"disease.",
"Furthermore,",
"the",
"most",
"important",
"factor",
"for",
"growing",
"of",
"tumorspheres",
"is",
"obtaining",
"chemotherapy.",
"Patients",
"with",
"chemotherapy",
"treatment",
"had",
"lower",
"numbers",
"of",
"tumorspheres",
"compared",
"to",
"patients",
"without",
"chemotherapy.",
"Patients",
"with",
"HER2",
"positive",
"primary",
"tumor",
"had",
"higher",
"number",
"of",
"tumorspheres.",
"Analysis",
"of",
"surface",
"marker",
"expression",
"profile",
"of",
"tumorspheres",
"showed",
"that",
"cells",
"in",
"the",
"spheres",
"had",
"typical",
"phenotype",
"of",
"cancer",
"stem",
"cells.",
"There",
"was",
"no",
"sphere",
"formation",
"in",
"a",
"control",
"group",
"with",
"50",
"healthy",
"donors.",
"This",
"study",
"demonstrates",
"that",
"a",
"small",
"fraction",
"of",
"CETCs",
"has",
"proliferative",
"activity.",
"Identifying",
"the",
"CETC",
"subset",
"with",
"cancer",
"stem",
"cell",
"properties",
"may",
"provide",
"more",
"clinically",
"useful",
"prognostic",
"information.",
"Chemotherapy",
"is",
"the",
"most",
"important",
"component",
"in",
"cancer",
"therapy",
"because",
"it",
"frequently",
"reduces",
"the",
"number",
"of",
"tumorspheres."
] | [
0,
0,
0,
1,
0,
0,
1,
2,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
1,
2,
1,
2,
0,
0,
0,
0,
0,
1,
2,
0,
1,
0,
1,
0,
1,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
1,
2,
1,
1,
0,
1,
1,
0,
0,
0,
0,
1,
2,
2,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
2,
2,
2,
1,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
0,
1,
2,
0,
0,
1,
0,
0,
1,
0,
1,
2,
1,
0,
0,
0,
0,
1,
2,
1,
2,
2,
0,
0,
1,
0,
1,
0,
0,
0,
1,
0,
0,
0,
1,
1,
1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
1,
0,
1,
1,
0,
0,
0,
0,
1,
0,
0,
1,
1,
2,
1,
0,
1,
2,
2,
2,
0,
0,
0,
0,
1,
0,
0,
1,
2,
1,
0,
0,
1,
0,
0,
1,
0,
0,
1,
0,
0,
1,
0,
1,
2,
2,
0,
0,
1,
2,
2,
0,
0,
1,
2,
0,
0,
1,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
1,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
1,
1,
1,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
1
] |
[
"Undiagnosed",
"Primary",
"Open-Angle",
"Glaucoma",
"in",
"Korea:",
"The",
"Korean",
"National",
"Health",
"and",
"Nutrition",
"Examination",
"Survey",
"2008-2009",
"To",
"evaluate",
"the",
"characteristics",
"of",
"patients",
"with",
"previously",
"undiagnosed",
"primary",
"open-angle",
"glaucoma",
"(POAG)",
"in",
"Korea.",
"This",
"study",
"examined",
"data",
"from",
"391",
"subjects",
"obtained",
"from",
"the",
"2008-2009",
"Korean",
"National",
"Health",
"and",
"Nutrition",
"Examination",
"Survey",
"(KNHANES).",
"The",
"KNHANES",
"is",
"a",
"population-based,",
"cross-sectional",
"epidemiological",
"survey.",
"Participants",
"aged",
"19",
"years",
"or",
"older",
"completed",
"standardized",
"interviews",
"and",
"dilated",
"ocular",
"examinations,",
"including",
"measurement",
"of",
"intraocular",
"pressure,",
"visual",
"fields",
"with",
"frequency",
"doubling",
"perimetry,",
"and",
"fundus",
"photography.",
"Data",
"from",
"the",
"361",
"patients",
"with",
"previously",
"undiagnosed",
"POAG",
"were",
"analyzed",
"and",
"compared",
"with",
"data",
"from",
"the",
"30",
"patients",
"with",
"previously",
"diagnosed",
"glaucoma.",
"A",
"total",
"of",
"92.3%",
"of",
"POAG",
"cases",
"were",
"undiagnosed",
"before",
"this",
"study.",
"Adjusted",
"for",
"age",
"and",
"sex,",
"the",
"strongest",
"risk",
"factor",
"for",
"undiagnosed",
"glaucoma",
"was",
"longer",
"elapsed",
"time",
"since",
"last",
"eye",
"doctor",
"visit.",
"Glaucoma",
"patients",
"who",
"had",
"not",
"visited",
"an",
"eye",
"specialist",
"in",
"the",
"last",
"3",
"years",
"were",
"22",
"times",
"(95%",
"confidence",
"interval,",
"CI,",
"4.49-105.64,",
"p",
"<",
"0.001)",
"more",
"likely",
"to",
"have",
"undiagnosed",
"disease",
"compared",
"with",
"patients",
"who",
"had",
"visited",
"an",
"eye",
"specialist",
"in",
"the",
"last",
"month.",
"Another",
"significant",
"factor",
"for",
"previously",
"undiagnosed",
"glaucoma",
"was",
"smaller",
"cup-to-disc",
"ratio",
"(odds",
"ratio,",
"OR,",
"0.60/0.1",
"units,",
"95%",
"CI",
"0.43-0.85/0.1",
"units,",
"p",
"=",
"0.004).",
"The",
"higher",
"vertical",
"cup-to-disc",
"ratio",
"of",
"a",
"subject's",
"two",
"eyes",
"was",
"significantly",
"different",
"between",
"those",
"with",
"previously",
"undiagnosed",
"(0.69)",
"and",
"diagnosed",
"(0.78)",
"POAG",
"(p",
"=",
"0.001).",
"The",
"undiagnosed",
"POAG",
"group",
"had",
"a",
"longer",
"interval",
"from",
"last",
"eye",
"doctor",
"visit",
"and",
"smaller",
"vertical",
"cup-to-disc",
"ratio",
"compared",
"to",
"the",
"diagnosed",
"group."
] | [
1,
1,
2,
2,
0,
1,
0,
1,
2,
2,
2,
2,
2,
2,
0,
0,
1,
0,
1,
0,
1,
0,
0,
1,
1,
2,
2,
1,
0,
1,
0,
1,
0,
1,
0,
0,
1,
1,
0,
0,
0,
1,
2,
2,
2,
2,
2,
2,
1,
0,
1,
0,
0,
1,
1,
2,
2,
1,
1,
1,
2,
0,
1,
0,
1,
2,
0,
1,
2,
2,
0,
1,
0,
1,
2,
1,
2,
0,
1,
2,
2,
0,
1,
2,
1,
0,
0,
0,
1,
0,
1,
1,
1,
0,
1,
0,
1,
0,
1,
0,
0,
0,
1,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
1,
1,
0,
1,
0,
1,
0,
1,
2,
2,
0,
1,
1,
0,
0,
1,
2,
0,
0,
1,
2,
2,
1,
1,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
2,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
1,
0,
1,
0,
0,
1,
2,
2,
2,
0,
0,
0,
1,
0,
1,
2,
0,
0,
1,
1,
0,
0,
1,
2,
1,
2,
1,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
1,
0,
1,
0,
0,
0,
0,
1,
1,
0,
0,
0,
1,
2,
0,
0,
1,
2,
2,
0,
0,
1,
2,
2,
0,
0,
0,
1,
2
] |
[
"Nest",
"-",
"site",
"competition",
"between",
"invasive",
"and",
"native",
"cavity",
"nesting",
"birds",
"and",
"its",
"implication",
"for",
"conservation",
"Nesting",
"cavities",
"are",
"often",
"a",
"limited",
"resource",
"that",
"multiple",
"species",
"use.",
"There",
"is",
"an",
"ongoing",
"discussion",
"on",
"whether",
"invasive",
"cavity",
"nesting",
"birds",
"restrict",
"the",
"availability",
"of",
"this",
"key",
"limited",
"resource.",
"While",
"the",
"answer",
"to",
"this",
"question",
"has",
"important",
"conservation",
"implications,",
"little",
"experimental",
"work",
"has",
"been",
"done",
"to",
"examine",
"it.",
"Here,",
"we",
"aimed",
"to",
"experimentally",
"test",
"whether",
"alien",
"cavity",
"nesting",
"birds",
"affect",
"the",
"occupancy",
"of",
"cavities",
"and",
"the",
"resulting",
"breeding",
"success",
"of",
"native",
"cavity",
"breeders",
"in",
"a",
"large",
"urban",
"park",
"located",
"in",
"Tel",
"Aviv,",
"Israel.",
"Over",
"three",
"breeding",
"seasons,",
"we",
"manipulated",
"the",
"entry",
"size",
"of",
"nest",
"boxes",
"and",
"compared",
"the",
"occupancy",
"and",
"breeding",
"success",
"of",
"birds",
"in",
"nest",
"boxes",
"of",
"two",
"treatments.",
"These",
"included",
"nest",
"boxes",
"with",
"large",
"-",
"entrance",
"and",
"small",
"-",
"entrance",
"holes.",
"The",
"large",
"-",
"entrance",
"holes",
"allowed",
"access",
"for",
"both",
"the",
"native",
"and",
"invasive",
"birds",
"(the",
"two",
"main",
"aliens",
"in",
"the",
"park",
"are",
"the",
"common",
"mynas",
"and",
"rose-ringed",
"parakeets).",
"The",
"smaller",
"-",
"entrance",
"boxes,",
"on",
"the",
"other",
"hand,",
"allowed",
"only",
"the",
"smaller",
"sized",
"native",
"cavity",
"breeders",
"(great",
"tits",
"and",
"house",
"sparrows)",
"to",
"enter",
"the",
"boxes",
"but",
"prevented",
"the",
"alien",
"species",
"from",
"entering.",
"We",
"found",
"that",
"the",
"large",
"-",
"entrance",
"nest",
"boxes",
"were",
"occupied",
"by",
"five",
"different",
"bird",
"species,",
"comprising",
"three",
"natives",
"(great",
"tit,",
"house",
"sparrow,",
"Scops",
"owl)",
"and",
"two",
"invasive",
"species",
"(common",
"myna,",
"rose-ringed",
"parakeet)",
"while",
"the",
"small",
"-",
"entrance",
"boxes",
"were",
"only",
"occupied",
"by",
"the",
"two",
"native",
"species.",
"The",
"alien",
"common",
"mynas",
"and",
"rose-ringed",
"parakeets",
"occupied",
"77.5%",
"of",
"the",
"large",
"-",
"entrance",
"nest",
"boxes",
"whereas",
"native",
"species,",
"mainly",
"great",
"tits,",
"occupied",
"less",
"than",
"9%",
"of",
"the",
"large",
"-",
"entrance",
"boxes",
"and",
"36.5%",
"of",
"the",
"small",
"-",
"entrance",
"boxes.",
"When",
"examining",
"the",
"occupancy",
"of",
"those",
"cavities",
"that",
"were",
"not",
"occupied",
"by",
"the",
"aliens,",
"natives",
"occupied",
"both",
"the",
"small",
"and",
"large",
"-",
"entrance",
"nest",
"boxes",
"equally.",
"Three",
"quarters",
"(78%)",
"of",
"the",
"great",
"tits",
"breeding",
"in",
"the",
"large",
"-",
"entrance",
"boxes",
"were",
"usurped",
"by",
"common",
"mynas",
"during",
"the",
"breeding",
"season",
"and",
"as",
"a",
"result",
"breeding",
"success",
"was",
"significantly",
"lower",
"for",
"great",
"tits",
"breeding",
"in",
"the",
"large",
"-",
"entrance",
"boxes",
"compared",
"with",
"the",
"small",
"-",
"entrance",
"boxes.",
"The",
"results",
"of",
"this",
"study",
"suggests",
"that",
"the",
"invasive",
"alien",
"species",
"can",
"reduce",
"the",
"breeding",
"potential",
"of",
"native",
"cavity",
"breeders",
"both",
"by",
"exploiting",
"the",
"limited",
"breeding",
"resource",
"(nest",
"cavities)",
"and",
"by",
"directly",
"usurping",
"cavities",
"already",
"occupied",
"by",
"the",
"native",
"species.",
"Since",
"the",
"majority",
"of",
"large",
"-",
"entrance",
"nest",
"boxes",
"were",
"occupied",
"by",
"the",
"large",
"r",
"alien",
"birds,",
"less",
"native",
"species",
"bred",
"in",
"the",
"limited",
"number",
"of",
"unoccupied",
"large",
"-",
"entrance",
"nest",
"boxes",
"because",
"of",
"exploitation",
"competition.",
"We",
"propose",
"that",
"for",
"management",
"purposes,",
"nest-box",
"programs",
"that",
"alter",
"the",
"entrance",
"size",
"of",
"available",
"natural",
"cavities",
"may",
"be",
"a",
"practical",
"approach,",
"reducing",
"the",
"competition",
"between",
"native",
"cavity",
"breeders",
"and",
"alien",
"invasive",
"birds,",
"and",
"especially",
"benefiting",
"the",
"smaller",
"native",
"cavity",
"breeders."
] | [
1,
0,
1,
1,
0,
1,
0,
1,
1,
1,
1,
0,
0,
1,
0,
1,
1,
1,
0,
0,
0,
1,
1,
0,
1,
1,
1,
0,
0,
0,
0,
1,
0,
0,
1,
1,
1,
1,
1,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
1,
1,
0,
0,
1,
0,
1,
0,
0,
0,
1,
1,
0,
1,
1,
1,
0,
0,
1,
1,
1,
0,
0,
1,
2,
1,
0,
0,
1,
1,
0,
1,
0,
1,
1,
0,
1,
2,
0,
1,
0,
1,
0,
1,
1,
0,
1,
0,
1,
2,
0,
0,
1,
0,
0,
1,
2,
0,
1,
0,
1,
0,
1,
0,
1,
1,
0,
1,
0,
1,
1,
0,
1,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
1,
0,
0,
1,
0,
0,
1,
2,
0,
1,
2,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
1,
1,
1,
1,
1,
2,
0,
1,
2,
0,
0,
0,
1,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
0,
1,
1,
2,
0,
1,
0,
0,
1,
1,
2,
0,
0,
1,
1,
2,
1,
2,
1,
2,
0,
0,
1,
1,
1,
2,
1,
2,
0,
0,
1,
0,
1,
1,
0,
0,
1,
0,
0,
0,
1,
1,
0,
1,
1,
2,
0,
1,
2,
1,
0,
0,
0,
1,
0,
1,
1,
2,
0,
1,
1,
1,
1,
2,
1,
1,
2,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
1,
0,
1,
1,
0,
1,
0,
1,
0,
0,
1,
0,
0,
0,
1,
0,
0,
1,
1,
1,
0,
0,
1,
0,
1,
0,
1,
1,
2,
0,
0,
1,
0,
0,
0,
1,
2,
1,
0,
0,
1,
0,
1,
1,
0,
1,
0,
1,
2,
0,
0,
1,
1,
0,
0,
0,
0,
1,
1,
0,
1,
1,
0,
1,
2,
1,
0,
0,
1,
0,
1,
1,
1,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
2,
0,
1,
0,
1,
1,
0,
1,
1,
1,
0,
0,
1,
0,
1,
1,
1,
1,
1,
0,
0,
1,
1,
1,
0,
1,
0,
0,
1,
1,
0,
0,
1,
0,
1,
0,
1,
1,
2,
0,
1,
0,
0,
1,
0,
1,
2,
0,
1,
1,
1,
0,
0,
1,
1,
0,
1,
1,
0,
1,
1,
2,
0,
0,
1,
1,
0,
0,
0,
0,
1,
1,
1,
1,
0,
1,
0,
1,
1,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
0,
1,
0,
1,
1,
1,
0,
1,
1,
2,
0,
0,
0,
0,
1,
1,
1,
1
] |
[
"Family",
"Psychosocial",
"Risk",
"Screening",
"in",
"Infants",
"and",
"Older",
"Children",
"in",
"the",
"Acute",
"Pediatric",
"Hospital",
"Setting",
"Using",
"the",
"Psychosocial",
"Assessment",
"Tool",
"To",
"examine",
"the",
"validity",
"of",
"the",
"Psychosocial",
"Assessment",
"Tool",
"(PAT)",
"with",
"families",
"of",
"infants",
"(<2",
"years)",
"and",
"children",
"admitted",
"to",
"hospital",
"with",
"acute",
"life-threatening",
"illnesses.",
"METHODS:",
"A",
"total",
"of",
"235",
"parents",
"of",
"177",
"children",
"admitted",
"to",
"oncology,",
"cardiology,",
"or",
"pediatric",
"intensive",
"care",
"completed",
"the",
"PAT",
"and",
"measures",
"of",
"acute",
"stress,",
"trait",
"anxiety,",
"family",
"functioning,",
"and",
"quality",
"of",
"life,",
"a",
"mean",
"3.7",
"weeks",
"following",
"diagnosis.",
"A",
"modified",
"PAT",
"was",
"used",
"for",
"families",
"of",
"infants,",
"rendering",
"two",
"forms,",
"PAT",
"(<2)",
"and",
"PAT",
"(2+).",
"RESULTS:",
"Psychometrics",
"for",
"PAT",
"(<2)",
"and",
"PAT",
"(2+)",
"were",
"acceptable.",
"PAT",
"Total",
"and",
"Subscale",
"scores",
"for",
"each",
"version",
"were",
"significantly",
"correlated",
"with",
"validation",
"measures.",
"Internal",
"consistency",
"for",
"PAT",
"subscales",
"was",
"variable.",
"Receiver",
"Operating",
"Characteristics",
"provided",
"some",
"support",
"for",
"PAT",
"cutoffs.",
"PAT",
"scores",
"across",
"illness",
"groups",
"were",
"comparable.",
"CONCLUSIONS:",
"This",
"study",
"provides",
"promising",
"support",
"for",
"the",
"PAT",
"as",
"a",
"psychosocial",
"screener",
"for",
"families",
"of",
"infants",
"and",
"older",
"children",
"across",
"illness",
"conditions."
] | [
1,
1,
1,
2,
0,
1,
0,
1,
2,
0,
0,
1,
1,
2,
2,
0,
0,
1,
1,
2,
0,
0,
0,
1,
0,
0,
1,
1,
2,
1,
0,
1,
0,
1,
1,
2,
0,
1,
1,
2,
2,
0,
1,
1,
1,
1,
0,
1,
0,
0,
1,
0,
0,
1,
1,
0,
1,
1,
0,
1,
2,
2,
1,
0,
1,
0,
1,
0,
1,
2,
1,
1,
1,
2,
0,
1,
2,
2,
0,
1,
0,
1,
0,
1,
0,
1,
1,
0,
0,
0,
1,
0,
1,
0,
0,
1,
1,
1,
0,
1,
1,
1,
1,
0,
1,
1,
0,
1,
1,
0,
1,
1,
1,
0,
1,
2,
0,
1,
1,
0,
1,
2,
0,
1,
1,
1,
2,
0,
1,
1,
0,
1,
1,
2,
2,
1,
0,
0,
0,
1,
1,
1,
1,
0,
1,
1,
0,
1,
1,
0,
1,
1,
1,
2,
0,
0,
1,
0,
0,
1,
1,
0,
1,
0,
1,
0,
1,
2,
0,
1,
1
] |
[
"Design",
"and",
"synthesis",
"of",
"pH",
"-",
"sensitive",
"polymeric",
"micelles",
"for",
"oral",
"delivery",
"of",
"poorly",
"water",
"-",
"soluble",
"drugs",
"pH",
"-",
"sensitive",
"polymer",
"poly",
"(polylactide-co-methacrylic",
"acid)-b-poly",
"(acrylic",
"acid)",
"was",
"synthesized",
"using",
"atom",
"transfer",
"radical",
"polymerization",
"and",
"ring-opening",
"polymerization",
"and",
"characterized",
"by",
"gel",
"permeation",
"chromatography",
"and",
"(1)H",
"NMR.",
"The",
"polymers",
"can",
"self-assemble",
"to",
"form",
"micelles",
"in",
"aqueous",
"medium,",
"which",
"respond",
"rapidly",
"to",
"pH",
"change",
"within",
"the",
"gastrointestinal",
"relevant",
"pH",
"range.",
"Critical",
"micelle",
"concentrations",
"and",
"pH",
"response",
"behavior",
"of",
"the",
"polymeri",
"c",
"micelle",
"were",
"investigated.",
"Water",
"-",
"insoluble",
"drug",
"nifedipine",
"was",
"loaded",
"and",
"the",
"drug",
"-",
"loading",
"content",
"can",
"be",
"controlled",
"by",
"tuning",
"the",
"composition",
"of",
"the",
"polymers.",
"The",
"in",
"vitro",
"release",
"studies",
"indicate",
"pH",
"sensitivity",
"enabled",
"rapid",
"drug",
"release",
"at",
"the",
"environment",
"of",
"simulated",
"intestinal",
"fluid",
"(pH",
"7.36),",
"the",
"cumulative",
"released",
"amount",
"of",
"NFD",
"reached",
"more",
"than",
"80%",
"within",
"24",
"h,",
"while",
"only",
"35%",
"in",
"the",
"simulated",
"gastric",
"fluid",
"(pH",
"1.35).",
"All",
"the",
"results",
"showed",
"that",
"the",
"pH",
"-",
"sensitive",
"P(PLAMA-co-MAA)-b-PAA",
"micelle",
"may",
"be",
"a",
"prospective",
"candidate",
"as",
"oral",
"drug",
"delivery",
"carrier",
"for",
"hydrophobic",
"drugs",
"with",
"controlled",
"release",
"behavior."
] | [
1,
0,
1,
0,
1,
0,
1,
1,
1,
0,
1,
1,
0,
1,
1,
0,
1,
1,
1,
0,
1,
1,
0,
2,
2,
2,
2,
0,
1,
0,
1,
2,
2,
2,
0,
1,
2,
0,
0,
0,
1,
2,
2,
0,
1,
2,
0,
1,
0,
1,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
1,
1,
0,
0,
1,
1,
1,
0,
0,
1,
1,
0,
1,
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
0,
1,
1,
1,
0,
1,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
2,
1,
1,
0,
1,
1,
0,
0,
1,
2,
0,
0,
1,
0,
0,
1,
2,
1,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
1,
1,
0,
0,
0,
0,
0,
0,
1,
1,
1,
2,
0,
1,
1,
0,
1,
2,
0
] |
[
"Targeting",
"tumor",
"tolerance:",
"A",
"new",
"hope",
"for",
"pancreatic",
"cancer",
"therapy?",
"With",
"a",
"5-year",
"survival",
"rate",
"of",
"just",
"8%,",
"pancreatic",
"cancer",
"(PC)",
"is",
"projected",
"to",
"be",
"the",
"second",
"leading",
"cause",
"of",
"cancer",
"deaths",
"by",
"2030.",
"Most",
"PC",
"patients",
"are",
"not",
"eligible",
"for",
"surgery",
"with",
"curative",
"intent",
"upon",
"diagnosis,",
"emphasizing",
"a",
"need",
"for",
"more",
"effective",
"therapies.",
"However,",
"PC",
"is",
"notoriously",
"resistant",
"to",
"chemoradiation",
"regimens.",
"As",
"an",
"alternative,",
"immune",
"modulating",
"strategies",
"have",
"recently",
"achieved",
"success",
"in",
"melanoma,",
"prompting",
"their",
"application",
"to",
"other",
"solid",
"tumors.",
"For",
"such",
"therapeutic",
"approaches",
"to",
"succeed,",
"a",
"state",
"of",
"immunologic",
"tolerance",
"must",
"be",
"reversed",
"in",
"the",
"tumor",
"microenvironment",
"and",
"that",
"has",
"been",
"especially",
"challenging",
"in",
"PC.",
"Nonetheless,",
"knowledge",
"of",
"the",
"PC",
"immune",
"microenvironment",
"has",
"advanced",
"considerably",
"over",
"the",
"past",
"decade,",
"yielding",
"new",
"insights",
"and",
"perspectives",
"to",
"guide",
"multimodal",
"therapies.",
"In",
"this",
"review,",
"we",
"catalog",
"the",
"historical",
"groundwork",
"and",
"discuss",
"the",
"evolution",
"of",
"the",
"cancer",
"immunology",
"field",
"to",
"its",
"present",
"state",
"with",
"a",
"specific",
"focus",
"on",
"PC.",
"Strategies",
"currently",
"employing",
"immune",
"modulation",
"in",
"PC",
"are",
"reviewed,",
"specifically",
"highlighting",
"66",
"clinical",
"trials",
"across",
"the",
"United",
"States",
"and",
"Europe."
] | [
1,
1,
1,
0,
0,
0,
0,
1,
2,
1,
0,
0,
0,
1,
2,
0,
0,
0,
1,
2,
1,
0,
0,
0,
0,
0,
1,
2,
1,
0,
1,
2,
0,
0,
0,
1,
1,
0,
0,
1,
0,
1,
0,
1,
2,
0,
1,
0,
0,
0,
0,
0,
1,
1,
0,
1,
0,
0,
1,
0,
1,
2,
0,
0,
1,
1,
2,
1,
0,
0,
0,
0,
0,
1,
1,
0,
1,
0,
0,
1,
2,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
1,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
1,
2,
0,
1,
0,
1,
0,
0,
0,
1,
2,
0,
0,
1,
2,
0,
1
] |
[
"Parent's",
"pro-health",
"awareness",
"concerning",
"oral",
"health",
"of",
"their",
"children",
"in",
"the",
"light",
"of",
"survey",
"research",
"Oral",
"hygiene",
"is",
"a",
"crucial",
"part",
"of",
"caring",
"for",
"young",
"children.",
"This",
"problem",
"is",
"frequently",
"marginalized",
"or",
"even",
"ignored",
"by",
"parents",
"/",
"guardians,",
"what",
"affects",
"child's",
"whole",
"further",
"life.",
"The",
"assessment",
"of",
"parents'",
"knowledge",
"concerning",
"oral",
"hygiene",
"and",
"prevention",
"of",
"dental",
"caries",
"in",
"infants",
"and",
"young",
"children.",
"The",
"test",
"group",
"consisted",
"of",
"parents,",
"as",
"well",
"as",
"men",
"and",
"women",
"currently",
"expecting",
"a",
"child.",
"The",
"study",
"was",
"conducted",
"in",
"a",
"form",
"of",
"a",
"survey,",
"using",
"an",
"original",
"questionnaire,",
"which",
"was",
"carried",
"out",
"in",
"several",
"hospitals",
"in",
"Lodz",
"and",
"online,",
"on",
"a",
"popular",
"local",
"forum",
"for",
"parents.",
"The",
"data",
"obtained",
"were",
"analyzed",
"statistically,",
"allowing",
"the",
"assessment",
"of",
"health",
"awareness",
"of",
"respondents",
"and",
"the",
"creation",
"of",
"various",
"profiles",
"of",
"parental",
"knowledge",
"on",
"the",
"subject",
"investigated.",
"Most",
"of",
"respondents",
"knew",
"the",
"age",
"at",
"which",
"milk",
"and",
"permanent",
"teeth",
"erupt,",
"gave",
"the",
"correct",
"frequency",
"of",
"brushing",
"child's",
"teeth",
"and",
"were",
"in",
"favor",
"of",
"limiting",
"sweets",
"in",
"the",
"diet.",
"A",
"total",
"of",
"59%",
"correctly",
"gave",
"the",
"number",
"of",
"deciduous",
"teeth",
"and",
"66%",
"had",
"heard",
"of",
"the",
"\"",
"bottle",
"tooth",
"decay",
"\".",
"All",
"respondents",
"thought",
"that",
"helping",
"and",
"controlling",
"a",
"child",
"while",
"brushing",
"their",
"teeth",
"is",
"indispensable,",
"but",
"they",
"did",
"not",
"know",
"the",
"best",
"time",
"to",
"start",
"using",
"the",
"toothpaste",
"with",
"fluoride.",
"The",
"information",
"about",
"child's",
"oral",
"hygiene",
"was",
"more",
"often",
"looked",
"for",
"by",
"women",
"(67%)",
"than",
"by",
"men",
"(29%).",
"The",
"study",
"also",
"showed",
"that",
"if",
"a",
"training",
"on",
"the",
"given",
"subject",
"was",
"organized,",
"60%",
"of",
"respondents",
"would",
"be",
"willing",
"to",
"participate",
"in",
"it.",
"In",
"the",
"test",
"group,",
"pro-health",
"awareness",
"is",
"insufficient",
"to",
"maintain",
"the",
"oral",
"health",
"of",
"the",
"offspring",
"and",
"requires",
"constant",
"developing.",
"oral",
"health",
"behaviors,",
"oral",
"health,",
"prophylaxis",
"of",
"dental",
"caries,",
"parent",
"questionnaire",
"survey."
] | [
1,
1,
2,
0,
1,
2,
0,
0,
1,
0,
0,
0,
0,
1,
2,
1,
2,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
0,
1,
1,
0,
0,
1,
0,
1,
0,
1,
0,
1,
1,
0,
1,
1,
0,
1,
0,
1,
1,
0,
1,
2,
0,
1,
0,
1,
2,
0,
1,
0,
1,
1,
0,
1,
2,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
0,
1,
0,
1,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
1,
0,
1,
0,
1,
0,
0,
0,
0,
1,
0,
1,
0,
1,
1,
0,
1,
2,
0,
0,
1,
0,
1,
2,
0,
1,
0,
0,
1,
0,
0,
0,
0,
1,
2,
0,
0,
1,
1,
0,
0,
1,
0,
0,
1,
0,
0,
1,
0,
1,
2,
1,
0,
0,
0,
1,
0,
1,
1,
1,
0,
0,
0,
0,
0,
1,
1,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
0,
0,
1,
0,
1,
0,
1,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
1,
0,
0,
1,
2,
2,
0,
1,
0,
1,
1,
2,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
1,
0,
0,
1,
0,
1,
0,
0,
0,
0,
1,
2,
1,
2,
0,
1,
0,
1,
0,
1,
2,
0,
0,
1,
0,
1,
1,
0,
1,
2,
2,
1,
2,
1,
0,
1,
2,
1,
1,
1
] |
[
"Depressive",
"symptoms",
"and",
"long-term",
"income:",
"The",
"Young",
"Finns",
"Study",
"Higher",
"depressive",
"symptoms",
"have",
"been",
"associated",
"with",
"lower",
"future",
"income.",
"However,",
"studies",
"examining",
"this",
"issue",
"have",
"had",
"limited",
"follow-up",
"times",
"and",
"have",
"used",
"self-reported",
"measures",
"of",
"income.",
"Also,",
"possible",
"confounders",
"or",
"mediators",
"have",
"not",
"been",
"accounted.",
"971",
"women",
"and",
"738",
"men",
"were",
"selected",
"from",
"the",
"ongoing",
"prospective",
"Young",
"Finns",
"Study",
"(YFS)",
"that",
"began",
"in",
"1980.",
"Depressive",
"symptoms",
"were",
"measured",
"in",
"1992",
"when",
"participants",
"were",
"from",
"15",
"to",
"30",
"years",
"old.",
"Information",
"on",
"annual",
"income",
"and",
"earnings",
"from",
"1993",
"to",
"2010",
"were",
"obtained",
"from",
"the",
"Finnish",
"Longitudinal",
"Employer-Employee",
"Data",
"(FLEED)",
"of",
"Statistics",
"Finland",
"and",
"linked",
"to",
"the",
"YFS.",
"Higher",
"depressive",
"symptoms",
"were",
"associated",
"with",
"lower",
"future",
"income",
"and",
"earnings.",
"For",
"men,",
"the",
"associations",
"were",
"robust",
"for",
"controlling",
"childhood",
"parental",
"socioeconomic",
"status,",
"history",
"of",
"unemployment,",
"and",
"adulthood",
"health",
"behavior,",
"but",
"attenuated",
"circa",
"35%",
"when",
"three",
"major",
"temperament",
"traits",
"were",
"taken",
"into",
"account.",
"For",
"women,",
"similar",
"pattern",
"was",
"found,",
"however,",
"in",
"the",
"models",
"adjusted",
"for",
"temperament",
"traits",
"the",
"associations",
"did",
"not",
"remain",
"statistically",
"significant.",
"The",
"association",
"between",
"depressive",
"symptoms",
"and",
"earnings",
"was",
"three",
"times",
"stronger",
"for",
"men",
"than",
"women.",
"Previous",
"depressive",
"episodes",
"could",
"have",
"influenced",
"on",
"some",
"participants",
"'",
"economic",
"and",
"educational",
"choices.",
"Higher",
"depressive",
"symptoms",
"in",
"adolescence",
"and",
"early",
"adulthood",
"lead",
"to",
"significant",
"future",
"losses",
"of",
"total",
"income",
"and",
"earnings,",
"and",
"this",
"association",
"is",
"particularly",
"strong",
"for",
"men."
] | [
1,
2,
0,
1,
1,
0,
1,
2,
2,
1,
1,
2,
0,
0,
1,
2,
1,
1,
1,
0,
1,
1,
0,
1,
0,
0,
1,
1,
1,
0,
0,
0,
1,
1,
0,
1,
0,
1,
1,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
1,
0,
1,
0,
0,
1,
1,
1,
2,
2,
1,
0,
0,
0,
0,
1,
2,
0,
1,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
2,
1,
0,
1,
1,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
2,
2,
2,
2,
2,
1,
0,
1,
0,
0,
1,
1,
1,
2,
0,
1,
2,
1,
1,
1,
0,
1,
0,
1,
0,
1,
0,
1,
0,
1,
1,
1,
1,
2,
1,
0,
1,
0,
1,
1,
2,
0,
1,
0,
0,
0,
0,
1,
1,
1,
0,
0,
0,
0,
0,
1,
1,
1,
0,
0,
0,
0,
0,
1,
1,
0,
1,
1,
0,
1,
0,
0,
0,
1,
2,
0,
1,
0,
1,
2,
0,
1,
0,
0,
0,
1,
0,
1,
0,
1,
1,
1,
2,
0,
0,
1,
0,
0,
1,
0,
1,
0,
1,
1,
1,
1,
2,
0,
1,
0,
0,
1,
0,
0,
1,
1,
1,
0,
1,
1,
0,
1,
0,
0,
1,
0,
0,
1,
0,
1
] |
[
"miR-376c",
"inhibits",
"cervical",
"cancer",
"cell",
"proliferation",
"and",
"invasion",
"by",
"targeting",
"BMI1",
"MicroRNAs",
"(miRNAs)",
"play",
"crucial",
"roles",
"in",
"cancer",
"development",
"and",
"progression.",
"The",
"purposes",
"of",
"this",
"study",
"were",
"to",
"explore",
"the",
"role",
"of",
"miR-376c",
"in",
"cervical",
"cancer",
"and",
"to",
"clarify",
"the",
"regulation",
"of",
"BMI1",
"by",
"miR-376c.",
"Quantitative",
"RT-PCR",
"was",
"used",
"to",
"measure",
"miR-376c",
"expression",
"in",
"cervical",
"cancer",
"tissues",
"and",
"cell",
"lines.",
"The",
"cell",
"proliferation,",
"cell",
"cycle",
"and",
"Transwell",
"invasion",
"assays",
"were",
"performed.",
"A",
"luciferase",
"reporter",
"assay",
"was",
"conducted",
"to",
"confirm",
"the",
"target",
"gene",
"of",
"miR-376c,",
"and",
"the",
"results",
"were",
"validated",
"in",
"cervical",
"cancer",
"cell",
"lines",
"and",
"tissues.",
"MiR-376c",
"was",
"significantly",
"downregulated",
"in",
"cervical",
"cancer",
"cell",
"lines",
"and",
"clinical",
"tissues.",
"Upregulation",
"of",
"miR-376c",
"impaired",
"cell",
"proliferation,",
"blocked",
"G1/S",
"checkpoint",
"of",
"cell",
"cycle",
"and",
"suppressed",
"cell",
"invasion",
"in",
"vitro.",
"BMI1",
"was",
"verified",
"as",
"a",
"direct",
"target",
"of",
"miR-376c,",
"which",
"was",
"further",
"confirmed",
"by",
"the",
"inverse",
"expression",
"of",
"miR-376c",
"and",
"BMI1",
"in",
"patient",
"specimens.",
"The",
"newly",
"identified",
"miR-376c",
"/",
"BMI1",
"pathway",
"provides",
"an",
"insight",
"into",
"cervical",
"cancer",
"progression",
"and",
"may",
"represent",
"a",
"novel",
"therapeutic",
"target."
] | [
1,
0,
1,
2,
1,
2,
0,
1,
0,
0,
1,
1,
1,
0,
0,
0,
0,
1,
1,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
0,
1,
1,
2,
0,
0,
0,
0,
1,
1,
0,
1,
2,
1,
0,
1,
2,
0,
1,
2,
1,
2,
0,
1,
2,
2,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
1,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
1,
2,
0,
1,
1,
0,
0,
1,
0,
1,
2,
1,
2,
0,
1,
1,
1,
0,
1,
0,
1,
2,
1,
1,
2,
0,
1,
2,
0,
1,
1,
1,
0,
2,
1,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
0,
1,
0,
1,
0,
1,
1,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
1,
2,
1,
0,
0,
0,
0,
0,
1,
1
] |
[
"Phenol",
"red",
"-",
"silk",
"tyrosine",
"cross-linked",
"hydrogels",
"Phenol",
"red",
"is",
"a",
"cytocompatible",
"pH",
"sensing",
"dye",
"that",
"is",
"commonly",
"added",
"to",
"cell",
"culture",
"media,",
"but",
"removed",
"from",
"some",
"media",
"formulations",
"due",
"to",
"its",
"structural",
"mimicry",
"of",
"estrogen.",
"Phenol",
"red",
"free",
"media",
"is",
"also",
"used",
"during",
"live",
"cell",
"imaging,",
"to",
"avoid",
"absorbance",
"and",
"fluorescence",
"quenching",
"of",
"fluorophores.",
"To",
"overcome",
"these",
"complications,",
"we",
"developed",
"cytocompatible",
"and",
"degradable",
"phenol",
"red",
"-",
"silk",
"tyrosine",
"cross-linked",
"hydrogels",
"using",
"horseradish",
"peroxidase",
"(HRP)",
"enzyme",
"and",
"hydrogen",
"peroxide",
"(H2O2).",
"Phenol",
"red",
"added",
"to",
"silk",
"during",
"tyrosine",
"crosslinking",
"accelerated",
"di-tyrosine",
"formation",
"in",
"a",
"concentration",
"-",
"dependent",
"reaction.",
"Phenol",
"red",
"diffusion",
"studies",
"and",
"UV-Vis",
"spectra",
"of",
"phenol",
"red",
"-",
"silk",
"tyrosine",
"hydrogels",
"at",
"different",
"pHs",
"showed",
"altered",
"absorption",
"bands,",
"confirming",
"entrapment",
"of",
"dye",
"within",
"the",
"hydrogel",
"network.",
"LC-MS",
"of",
"HRP",
"-reacted",
"phenol",
"red",
"and",
"N-acetyl-l-tyrosine",
"reaction",
"products",
"confirmed",
"covalent",
"bonds",
"between",
"the",
"phenolic",
"hydroxyl",
"group",
"of",
"phenol",
"red",
"and",
"tyrosine",
"on",
"the",
"silk.",
"At",
"lower",
"phenol",
"red",
"concentrations,",
"leak-proof",
"hydrogels",
"which",
"did",
"not",
"release",
"phenol",
"red",
"were",
"fabricated",
"and",
"found",
"to",
"be",
"cytocompatible",
"based",
"on",
"live-dead",
"staining",
"and",
"alamar",
"blue",
"assessments",
"of",
"encapsulated",
"fibroblasts.",
"Due",
"to",
"the",
"spectral",
"overlap",
"between",
"phenol",
"red",
"absorbance",
"at",
"415",
"nm",
"and",
"di-tyrosine",
"fluorescence",
"at",
"417",
"nm,",
"phenol",
"red",
"-",
"silk",
"hydrogels",
"provide",
"both",
"absorbance",
"and",
"fluorescence",
"-based",
"pH",
"sensing.",
"With",
"an",
"average",
"pKa",
"of",
"6.8",
"and",
"good",
"cytocompatibiltiy,",
"phenol",
"red",
"-",
"silk",
"hydrogels",
"are",
"useful",
"for",
"pH",
"sensing",
"in",
"phenol",
"red",
"free",
"systems,",
"cellular",
"microenvironments",
"and",
"bioreactors.",
"Phenol",
"red",
"entrapped",
"within",
"hydrogels",
"facilitates",
"pH",
"sensing",
"in",
"phenol",
"red",
"free",
"environments.",
"Leak-proof",
"phenol",
"red",
"based",
"pH",
"sensors",
"require",
"covalent",
"binding",
"techniques,",
"but",
"are",
"complicated",
"due",
"to",
"the",
"lack",
"of",
"amino",
"or",
"carboxyl",
"groups",
"on",
"phenol",
"red.",
"Currently,",
"there",
"is",
"no",
"simple,",
"reliable",
"technique",
"to",
"covalently",
"link",
"phenol",
"red",
"to",
"hydrogel",
"matrices,",
"for",
"real-time",
"pH",
"sensing",
"in",
"cell",
"culture",
"environments.",
"Herein,",
"we",
"take",
"advantage",
"of",
"phenolic",
"groups",
"for",
"covalent",
"linkage",
"of",
"phenol",
"red",
"to",
"silk",
"tyrosine",
"in",
"the",
"presence",
"of",
"HRP",
"and",
"H2O2.",
"The",
"novelty",
"of",
"the",
"current",
"system",
"stems",
"from",
"its",
"simplicity",
"and",
"the",
"use",
"of",
"silk",
"protein",
"to",
"create",
"a",
"cytocompatible,",
"degradable",
"sensor",
"capable",
"of",
"real-time",
"pH",
"sensing",
"in",
"cell",
"culture",
"microenvironments."
] | [
1,
2,
0,
1,
2,
1,
1,
1,
2,
0,
0,
1,
1,
2,
2,
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
0,
0,
1,
0,
0,
0,
0,
1,
1,
0,
1,
1,
2,
0,
1,
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
0,
1,
2,
0,
1,
0,
1,
0,
1,
0,
0,
1,
0,
1,
1,
2,
0,
1,
2,
1,
1,
0,
1,
2,
2,
2,
0,
1,
2,
1,
1,
2,
0,
0,
1,
0,
1,
1,
1,
1,
1,
0,
0,
1,
0,
1,
2,
1,
2,
1,
1,
0,
1,
2,
0,
1,
2,
0,
1,
2,
1,
0,
0,
1,
0,
1,
1,
0,
1,
1,
0,
1,
0,
0,
1,
2,
1,
0,
1,
0,
1,
2,
0,
1,
1,
2,
1,
1,
2,
0,
0,
1,
2,
2,
0,
1,
2,
0,
1,
0,
0,
1,
0,
0,
1,
2,
1,
0,
1,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
0,
1,
2,
1,
0,
1,
1,
0,
0,
0,
1,
2,
0,
1,
2,
1,
0,
0,
1,
0,
1,
1,
0,
0,
1,
1,
2,
0,
1,
1,
0,
0,
1,
0,
1,
0,
1,
2,
0,
0,
0,
1,
0,
0,
0,
1,
1,
1,
2,
0,
1,
1,
0,
0,
0,
1,
2,
0,
1,
2,
2,
2,
1,
2,
0,
1,
1,
2,
1,
0,
1,
0,
1,
2,
0,
1,
2,
1,
2,
0,
1,
2,
0,
1,
2,
0,
1,
2,
2,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
1,
2,
0,
1,
2,
0,
0,
0,
1,
2,
1,
1,
0,
1,
1,
1,
2,
0,
1,
0,
0,
1,
1,
2,
0,
1,
2,
1,
0,
0,
0,
0,
0,
1,
2,
0,
1,
1,
0,
1,
2,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
0,
1,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
1,
1,
0,
0,
1,
1,
2,
0,
1,
2,
2
] |
[
"Online",
"public",
"reactions",
"to",
"frequency",
"of",
"diagnostic",
"errors",
"in",
"US",
"outpatient",
"care",
"Diagnostic",
"errors",
"pose",
"a",
"significant",
"threat",
"to",
"patient",
"safety",
"but",
"little",
"is",
"known",
"about",
"public",
"perceptions",
"of",
"diagnostic",
"errors.",
"A",
"study",
"published",
"in",
"BMJ",
"Quality",
"&",
"Safety",
"in",
"2014",
"estimated",
"that",
"diagnostic",
"errors",
"affect",
"at",
"least",
"5%",
"of",
"US",
"adults",
"(or",
"12",
"million)",
"per",
"year.",
"We",
"sought",
"to",
"explore",
"online",
"public",
"reactions",
"to",
"media",
"reports",
"on",
"the",
"reported",
"frequency",
"of",
"diagnostic",
"errors",
"in",
"the",
"US",
"adult",
"population.",
"We",
"searched",
"the",
"World",
"Wide",
"Web",
"for",
"any",
"news",
"article",
"reporting",
"findings",
"from",
"the",
"study.",
"We",
"then",
"gathered",
"all",
"the",
"online",
"comments",
"made",
"in",
"response",
"to",
"the",
"news",
"articles",
"to",
"evaluate",
"public",
"reaction",
"to",
"the",
"newly",
"reported",
"diagnostic",
"error",
"frequency",
"(n=241).",
"Two",
"coders",
"conducted",
"content",
"analyses",
"of",
"the",
"comments",
"and",
"an",
"experienced",
"qualitative",
"researcher",
"resolved",
"differences.",
"Overall,",
"there",
"were",
"few",
"comments",
"made",
"regarding",
"the",
"frequency",
"of",
"diagnostic",
"errors.",
"However,",
"in",
"response",
"to",
"the",
"media",
"coverage,",
"44",
"commenters",
"shared",
"personal",
"experiences",
"of",
"diagnostic",
"errors.",
"Additionally,",
"commentary",
"centered",
"on",
"diagnosis",
"-",
"related",
"quality",
"of",
"care",
"as",
"affected",
"by",
"two",
"emergent",
"categories:",
"(1)",
"US",
"health",
"care",
"providers",
"(n=79;",
"63",
"commenters)",
"and",
"(2)",
"US",
"health",
"care",
"reform-related",
"policies,",
"most",
"commonly",
"the",
"Affordable",
"Care",
"Act",
"(ACA)",
"and",
"insurance/reimbursement",
"issues",
"(n=62;",
"47",
"commenters).",
"The",
"public",
"appears",
"to",
"have",
"substantial",
"concerns",
"about",
"the",
"impact",
"of",
"the",
"ACA",
"and",
"other",
"reform",
"initiatives",
"on",
"the",
"diagnosis",
"-",
"related",
"quality",
"of",
"care.",
"However,",
"policy",
"discussions",
"on",
"diagnostic",
"errors",
"are",
"largely",
"absent",
"from",
"the",
"current",
"national",
"conversation",
"on",
"improving",
"quality",
"and",
"safety.",
"Because",
"outpatient",
"diagnostic",
"errors",
"have",
"emerged",
"as",
"a",
"major",
"safety",
"concern,",
"researchers",
"and",
"policymakers",
"should",
"consider",
"evaluating",
"the",
"effects",
"of",
"policy",
"and",
"practice",
"changes",
"on",
"diagnostic",
"accuracy."
] | [
1,
2,
2,
0,
1,
0,
1,
2,
0,
1,
1,
2,
1,
2,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
1,
1,
0,
1,
2,
0,
1,
1,
0,
1,
2,
2,
2,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
2,
2,
0,
1,
1,
0,
0,
0,
1,
0,
1,
2,
0,
0,
1,
1,
1,
0,
0,
0,
1,
2,
2,
0,
0,
1,
1,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
1,
1,
0,
0,
1,
0,
0,
1,
1,
0,
1,
1,
2,
0,
0,
0,
0,
1,
2,
1,
0,
0,
1,
0,
1,
2,
0,
0,
1,
0,
0,
1,
1,
1,
1,
1,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
2,
0,
0,
1,
0,
0,
1,
2,
0,
1,
0,
1,
2,
0,
1,
2,
0,
1,
0,
0,
1,
0,
1,
1,
2,
2,
0,
0,
0,
0,
0,
1,
0,
1,
1,
2,
2,
0,
0,
1,
0,
0,
1,
1,
2,
2,
2,
0,
0,
0,
1,
2,
2,
1,
0,
1,
2,
0,
0,
1,
0,
1,
0,
0,
0,
1,
2,
0,
0,
1,
0,
0,
1,
0,
0,
1,
2,
0,
0,
1,
0,
1,
1,
2,
2,
0,
1,
1,
0,
1,
2,
0,
0,
1,
0,
0,
0,
1,
2,
0,
0,
1,
0,
1,
0,
1,
1,
2,
0,
0,
0,
0,
0,
1,
1,
1,
0,
1,
0,
0,
1,
0,
1,
2,
1,
0,
1,
1,
0,
1,
2
] |
[
"Retroperitoneal",
"hemorrhage",
"after",
"ureteroscopy",
"without",
"laser",
"lithotripsy:",
"an",
"extreme",
"example",
"of",
"an",
"underreported",
"event?",
"Retroperitoneal",
"hemorrhage",
"and",
"an",
"associated",
"hematoma",
"are",
"uncommon",
"but",
"potentially",
"serious",
"complications",
"following",
"ureteroscopy",
"with",
"laser",
"lithotripsy.",
"However,",
"no",
"reports",
"of",
"serious",
"bleeding",
"complications",
"have",
"been",
"published",
"regarding",
"ureteroscopy",
"without",
"laser",
"lithotripsy",
"in",
"the",
"management",
"of",
"stone",
"disease.",
"We",
"report",
"of",
"such",
"a",
"case",
"here",
"and",
"then",
"review",
"the",
"current",
"literature",
"in",
"order",
"to",
"discuss",
"the",
"incidence,",
"risk",
"factors,",
"and",
"management",
"of",
"such",
"events."
] | [
1,
2,
0,
1,
1,
1,
2,
0,
0,
0,
0,
0,
1,
1,
1,
2,
0,
0,
0,
1,
0,
1,
0,
0,
1,
1,
1,
1,
0,
1,
2,
0,
1,
2,
0,
1,
1,
1,
0,
0,
0,
0,
1,
1,
1,
2,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
1,
1,
2,
0,
1,
0,
0,
1
] |
[
"Characterization",
"and",
"Genomic",
"Analysis",
"of",
"a",
"Highly",
"Efficient",
"Dibutyl",
"Phthalate",
"-",
"Degrading",
"Bacterium",
"Gordonia",
"sp.",
"Strain",
"QH-12",
"A",
"bacterial",
"strain",
"QH-12",
"isolated",
"from",
"activated",
"sludge",
"was",
"identified",
"as",
"Gordonia",
"sp.",
"based",
"on",
"analysis",
"of",
"16S",
"rRNA",
"gene",
"sequence",
"and",
"was",
"found",
"to",
"be",
"capable",
"of",
"utilizing",
"dibutyl",
"phthalate",
"(DBP)",
"and",
"other",
"common",
"phthalate",
"esters",
"(PAEs)",
"as",
"the",
"sole",
"carbon",
"and",
"energy",
"source.",
"The",
"degradation",
"kinetics",
"of",
"DBP",
"under",
"different",
"concentrations",
"by",
"the",
"strain",
"QH-12",
"fit",
"well",
"with",
"the",
"modified",
"Gompertz",
"model",
"(R²",
">",
"0.98).",
"However,",
"strain",
"QH-12",
"could",
"not",
"utilize",
"the",
"major",
"intermediate",
"product",
"phthalate",
"(phthalic",
"acid;",
"PA)",
"as",
"the",
"sole",
"carbon",
"and",
"energy",
"source,",
"and",
"only",
"a",
"little",
"amount",
"of",
"PA",
"was",
"detected.",
"The",
"QH-12",
"genome",
"analysis",
"revealed",
"the",
"presence",
"of",
"putative",
"hydrolase",
"/",
"esterase",
"genes",
"involved",
"in",
"PAEs",
"-",
"degradation",
"but",
"no",
"phthalic",
"acid",
"catabolic",
"gene",
"cluster",
"was",
"found,",
"suggesting",
"that",
"a",
"novel",
"degradation",
"pathway",
"of",
"PAEs",
"was",
"present",
"in",
"Gordonia",
"sp.",
"QH-12.",
"This",
"information",
"will",
"be",
"valuable",
"for",
"obtaining",
"a",
"more",
"holistic",
"understanding",
"on",
"diverse",
"genetic",
"mechanisms",
"of",
"PAEs",
"-degrading",
"Gordonia",
"sp.",
"strains."
] | [
1,
0,
1,
2,
0,
0,
1,
2,
1,
2,
0,
1,
1,
2,
2,
2,
2,
0,
1,
2,
2,
1,
0,
1,
2,
0,
0,
0,
1,
2,
0,
0,
1,
0,
1,
2,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
1,
0,
0,
0,
1,
2,
1,
0,
0,
0,
1,
0,
1,
2,
0,
1,
1,
0,
1,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
2,
2,
1,
1,
2,
1,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
1,
2,
0,
1,
0,
1,
0,
1,
1,
2,
0,
0,
0,
0,
1,
2,
0,
1,
2,
0,
0,
1,
0,
1,
0,
0,
1,
2,
1,
1,
2,
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
1,
0,
1,
2,
2
] |
[
"Multimorbidity",
"in",
"Heart",
"Failure:",
"Effect",
"on",
"Outcomes",
"To",
"investigate",
"the",
"effect",
"of",
"the",
"number",
"and",
"type",
"of",
"comorbid",
"conditions",
"on",
"death",
"and",
"hospitalizations",
"in",
"individuals",
"with",
"incident",
"heart",
"failure",
"(HF).",
"Population-based",
"cohort",
"study.",
"Olmsted",
"County,",
"Minnesota.",
"Olmsted",
"County,",
"Minnesota,",
"residents",
"with",
"incident",
"HF",
"from",
"2000",
"to",
"2010",
"(mean",
"age",
"76",
"±",
"14,",
"56%",
"female)",
"(N",
"=",
"1,714).",
"The",
"prevalence",
"of",
"16",
"chronic",
"conditions",
"obtained",
"at",
"HF",
"diagnosis",
"classified",
"into",
"three",
"groups:",
"cardiovascular",
"(CV)",
"related,",
"other",
"physical,",
"and",
"mental.",
"The",
"mean",
"number",
"of",
"conditions",
"per",
"participant",
"was",
"2.6",
"±",
"1.5",
"for",
"CV",
"-related",
"conditions,",
"1.3",
"±",
"1.1",
"for",
"other",
"physical",
"conditions,",
"and",
"0.30",
"±",
"0.61",
"for",
"mental",
"conditions.",
"After",
"a",
"mean",
"follow-up",
"of",
"4.2",
"years,",
"1,073",
"death",
"s",
"and",
"6,306",
"hospitalizations",
"had",
"occurred.",
"After",
"adjustment",
"for",
"age,",
"sex,",
"ejection",
"fraction,",
"in-",
"or",
"outpatient",
"status,",
"and",
"number",
"of",
"other",
"conditions,",
"an",
"increase",
"of",
"one",
"other",
"physical",
"condition",
"was",
"associated",
"with",
"a",
"14%",
"(HR",
"=",
"1.14,",
"95%",
"CI",
"=",
"1.08-1.20)",
"greater",
"risk",
"of",
"death",
"and",
"a",
"26%",
"(HR",
"=",
"1.26,",
"95%",
"CI",
"=",
"1.20-1.32)",
"greater",
"risk",
"of",
"hospitalization,",
"and",
"an",
"increase",
"of",
"one",
"mental",
"condition",
"was",
"associated",
"with",
"a",
"31%",
"(HR",
"=",
"1.31,",
"95%",
"CI",
"=",
"1.19-1.44)",
"greater",
"risk",
"of",
"death",
"and",
"an",
"18%",
"(HR",
"=",
"1.18,",
"95%",
"CI",
"=",
"1.07-1.29)",
"greater",
"risk",
"of",
"hospitalization.",
"In",
"contrast,",
"an",
"increase",
"of",
"one",
"CV",
"-related",
"condition",
"was",
"not",
"associated",
"with",
"greater",
"risk",
"of",
"death",
"and",
"was",
"associated",
"with",
"a",
"10%",
"(HR",
"=",
"1.10,",
"95%",
"CI",
"=",
"1.06-1.15)",
"greater",
"risk",
"of",
"hospitalization.",
"CV",
"-related",
"conditions",
"are",
"the",
"most",
"common",
"type",
"of",
"comorbid",
"conditions",
"in",
"individuals",
"with",
"HF,",
"but",
"other",
"physical",
"and",
"mental",
"conditions",
"are",
"more",
"strongly",
"associated",
"with",
"death",
"and",
"hospitalizations.",
"This",
"underscores",
"the",
"effect",
"of",
"non-CV",
"conditions",
"on",
"outcomes",
"in",
"HF."
] | [
1,
0,
1,
2,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
1,
0,
1,
0,
1,
0,
0,
1,
2,
1,
1,
1,
2,
1,
2,
2,
1,
2,
2,
0,
0,
0,
1,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
1,
1,
0,
0,
0,
0,
1,
1,
0,
0,
1,
0,
1,
0,
1,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
1,
1,
2,
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
0,
1,
0,
1,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1
] |
[
"Contemporary",
"mandibular",
"reconstruction",
"Multiple",
"disease",
"processes,",
"including",
"neoplasia,",
"trauma,",
"and",
"medication",
"side-effects,",
"necessitate",
"segmental",
"resection",
"and",
"subsequent",
"reconstruction",
"of",
"the",
"mandible.",
"As",
"surgical",
"techniques",
"have",
"advanced,",
"several",
"technologies",
"have",
"been",
"developed",
"with",
"the",
"potential",
"to",
"significantly",
"transform",
"a",
"surgeon's",
"approach",
"to",
"the",
"restoration",
"of",
"mandibular",
"continuity.",
"The",
"purpose",
"of",
"this",
"review",
"is",
"to",
"highlight",
"many",
"of",
"these",
"relatively",
"newer",
"tools",
"and",
"discuss",
"their",
"evolving",
"role",
"in",
"mandibular",
"reconstruction.",
"Several",
"contemporary",
"studies",
"have",
"documented",
"the",
"application",
"of",
"different",
"approaches",
"and",
"modifications",
"to",
"mandibular",
"reconstruction",
"-",
"including",
"computer-aided",
"design",
"or",
"computer-aided",
"modeling,",
"contemporary",
"plating",
"systems,",
"osseointegrated",
"implants,",
"and",
"various",
"modifications",
"to",
"existing",
"osseocutaneous",
"free",
"tissue",
"transfer",
"options",
"-",
"and",
"have",
"reported",
"relatively",
"high",
"success",
"rates.",
"In",
"discussing",
"these",
"reports,",
"we",
"present",
"a",
"survey",
"of",
"current",
"and",
"developing",
"technologies",
"in",
"the",
"field",
"of",
"mandibular",
"reconstruction",
"and",
"aim",
"to",
"provide",
"sufficient",
"context",
"for",
"the",
"gradual",
"integration",
"of",
"these",
"techniques",
"into",
"practice."
] | [
1,
1,
2,
1,
1,
2,
0,
1,
1,
0,
1,
2,
0,
1,
2,
0,
1,
1,
2,
2,
2,
0,
1,
2,
0,
1,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
1,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
0,
1,
2,
0,
1,
0,
0,
0,
0,
1,
0,
1,
0,
1,
2,
0,
0,
1,
2,
0,
1,
2,
1,
1,
2,
1,
2,
0,
0,
1,
0,
0,
1,
2,
2,
1,
2,
0,
0,
0,
0,
0,
1,
1,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1
] |
[
"Radiolabeled",
"B9958",
"Derivatives",
"for",
"Imaging",
"Bradykinin",
"B1",
"Receptor",
"Expression",
"with",
"Positron",
"Emission",
"Tomography:",
"Effect",
"of",
"the",
"Radiolabel",
"-",
"Chelator",
"Complex",
"on",
"Biodistribution",
"and",
"Tumor",
"Uptake",
"Bradykinin",
"B1",
"receptor",
"(B1R),",
"which",
"is",
"upregulated",
"in",
"a",
"variety",
"of",
"malignancies,",
"is",
"an",
"attractive",
"cancer",
"imaging",
"biomarker.",
"In",
"this",
"study",
"we",
"optimized",
"the",
"selection",
"of",
"radiolabel",
"-",
"chelator",
"complex",
"to",
"improve",
"tumor",
"uptake",
"and",
"tumor",
"-to-background",
"contrast",
"of",
"radiolabeled",
"analogues",
"of",
"B9958",
"(Lys-Lys-Arg-Pro-Hyp-Gly-Cpg-Ser-d-Tic-Cpg),",
"a",
"potent",
"B1R",
"antagonist.",
"Peptide",
"sequences",
"were",
"assembled",
"on",
"solid",
"phase.",
"Cold",
"standards",
"were",
"prepared",
"by",
"incubating",
"DOTA",
"-/",
"NODA",
"-",
"conjugated",
"peptides",
"with",
"GaCl3,",
"and",
"by",
"incubating",
"AlOH",
"-",
"NODA",
"-conjugated",
"peptide",
"with",
"NaF.",
"Binding",
"affinities",
"were",
"measured",
"via",
"in",
"vitro",
"competition",
"binding",
"assays.",
"(68)Ga",
"and",
"(18)F",
"labeling",
"experiments",
"were",
"performed",
"in",
"acidic",
"buffer",
"and",
"purified",
"by",
"HPLC.",
"Imaging",
"/",
"biodistribution",
"studies",
"were",
"performed",
"in",
"mice",
"bearing",
"both",
"B1R-positive",
"(B1R+)",
"HEK293T",
"::",
"hB1R",
"and",
"B1R-negative",
"(B1R-)",
"HEK293T",
"tumors.",
"Z02176",
"(Ga-DOTA-Pip-B9958;",
"Pip:",
"4-amino-(1-carboxymethyl)piperidine),",
"Z02137",
"(Ga-NODA-Mpaa-Pip-B9958;",
"Mpaa:",
"4-methylphenylacetic",
"acid),",
"and",
"Z04139",
"(AlF-NODA-Mpaa-Pip-B9958)",
"bound",
"h",
"B1R",
"with",
"high",
"affinity",
"(Ki",
"=",
"1.4-2.5",
"nM).",
"(68)Ga",
"-/",
"(18)F",
"-",
"labeled",
"peptides",
"were",
"obtained",
"on",
"average",
"in",
"≥32%",
"decay-corrected",
"radiochemical",
"yield",
"with",
">99%",
"radiochemical",
"purity",
"and",
"100-261",
"GBq/μmol",
"specific",
"activity.",
"Biodistribution",
"/",
"imaging",
"studies",
"at",
"1",
"h",
"postinjection",
"showed",
"that",
"all",
"tracers",
"cleared",
"rapidly",
"from",
"background",
"tissues",
"(except",
"kidneys)",
"and",
"were",
"excreted",
"predominantly",
"via",
"the",
"renal",
"pathway.",
"Only",
"kidneys,",
"bladders,",
"and",
"B1R+",
"tumors",
"were",
"clearly",
"visualized",
"in",
"PET",
"images.",
"Uptake",
"in",
"B1R+",
"tumor",
"was",
"higher",
"by",
"using",
"(68)Ga",
"-",
"Z02176",
"(28.9",
"±",
"6.21",
"%ID/g)",
"and",
"(18)F",
"-",
"Z04139",
"(22.6",
"±",
"3.41",
"%ID/g)",
"than",
"(68)Ga",
"-",
"Z02137",
"(14.0",
"±",
"4.86",
"%ID/g).",
"The",
"B1R+",
"tumor-to-blood",
"and",
"B1R+",
"tumor-to-muscle",
"contrast",
"ratios",
"were",
"also",
"higher",
"for",
"(68)Ga",
"-",
"Z02176",
"(56.1",
"±",
"17.3",
"and",
"167",
"±",
"57.6)",
"and",
"(18)F",
"-",
"Z04139",
"(58.0",
"±",
"20.9",
"and",
"173",
"±",
"42.9)",
"than",
"(68)Ga",
"-",
"Z02137",
"(34.3",
"±",
"15.2",
"and",
"103",
"±",
"30.2).",
"With",
"improved",
"target-to-background",
"contrast",
"(68)Ga",
"-",
"Z02176",
"and",
"(18)F",
"-",
"Z04139",
"are",
"promising",
"for",
"imaging",
"B1R",
"expression",
"in",
"cancers",
"with",
"PET."
] | [
1,
1,
2,
0,
1,
1,
2,
2,
1,
0,
1,
2,
2,
0,
0,
0,
1,
0,
1,
1,
0,
1,
0,
1,
1,
1,
2,
2,
1,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
1,
2,
1,
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
1,
1,
0,
1,
0,
0,
0,
1,
1,
0,
1,
1,
0,
0,
1,
2,
1,
2,
0,
0,
0,
1,
2,
1,
2,
0,
0,
0,
0,
1,
0,
1,
0,
1,
1,
0,
1,
0,
0,
0,
1,
0,
1,
0,
1,
0,
1,
1,
1,
0,
0,
0,
1,
2,
2,
2,
2,
1,
0,
1,
1,
2,
0,
0,
0,
1,
2,
0,
0,
0,
1,
1,
0,
1,
1,
0,
0,
0,
1,
0,
0,
1,
1,
1,
0,
1,
0,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
2,
0,
1,
1,
0,
0,
1,
0,
0,
1,
0,
0,
0,
0,
1,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
1,
1,
0,
0,
0,
1,
1,
1,
0,
1,
1,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
0,
0,
0,
1,
2,
0,
1,
1,
0,
1,
1,
0,
0,
0,
0,
1,
1,
1,
0,
1,
1,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
1,
2,
0,
1,
2,
2,
2,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
1,
0,
1,
0,
1,
0,
1,
0,
0,
0,
1,
1,
1,
0,
1,
0,
1
] |
[
"Heterogeneous",
"silicon",
"mesostructures",
"for",
"lipid",
"-supported",
"bioelectric",
"interfaces",
"Silicon",
"-based",
"materials",
"have",
"widespread",
"application",
"as",
"biophysical",
"tools",
"and",
"biomedical",
"devices.",
"Here",
"we",
"introduce",
"a",
"biocompatible",
"and",
"degradable",
"mesostructured",
"form",
"of",
"silicon",
"with",
"multi-scale",
"structural",
"and",
"chemical",
"heterogeneities.",
"The",
"material",
"was",
"synthesized",
"using",
"mesoporous",
"silica",
"as",
"a",
"template",
"through",
"a",
"chemical",
"vapour",
"deposition",
"process.",
"It",
"has",
"an",
"amorphous",
"atomic",
"structure,",
"an",
"ordered",
"nanowire",
"-based",
"framework",
"and",
"random",
"submicrometre",
"voids,",
"and",
"shows",
"an",
"average",
"Young's",
"modulus",
"that",
"is",
"2-3",
"orders",
"of",
"magnitude",
"smaller",
"than",
"that",
"of",
"single-crystalline",
"silicon.",
"In",
"addition,",
"we",
"used",
"the",
"heterogeneous",
"silicon",
"mesostructures",
"to",
"design",
"a",
"lipid-bilayer",
"-supported",
"bioelectric",
"interface",
"that",
"is",
"remotely",
"controlled",
"and",
"temporally",
"transient,",
"and",
"that",
"permits",
"non",
"-",
"genetic",
"and",
"subcellular",
"optical",
"modulation",
"of",
"the",
"electrophysiology",
"dynamics",
"in",
"single",
"dorsal",
"root",
"ganglia",
"neurons.",
"Our",
"findings",
"suggest",
"that",
"the",
"biomimetic",
"expansion",
"of",
"silicon",
"into",
"heterogeneous",
"and",
"deformable",
"forms",
"can",
"open",
"up",
"opportunities",
"in",
"extracellular",
"biomaterial",
"or",
"bioelectric",
"systems."
] | [
1,
1,
1,
0,
1,
0,
1,
1,
1,
0,
1,
0,
1,
0,
0,
1,
1,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
1,
0,
1,
2,
0,
1,
1,
0,
1,
0,
1,
0,
1,
2,
0,
0,
1,
0,
0,
1,
2,
2,
2,
0,
0,
0,
1,
1,
1,
0,
1,
1,
0,
0,
0,
1,
1,
1,
0,
0,
0,
1,
1,
2,
0,
0,
0,
0,
0,
1,
1,
2,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
1,
1,
0,
0,
0,
1,
0,
1,
1,
0,
0,
1,
1,
0,
1,
2,
0,
0,
1,
1,
0,
1,
0,
1,
1,
2,
0,
0,
1,
1,
0,
1,
1,
2,
2,
1,
0,
0,
0,
0,
0,
1,
1,
0,
1,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
1,
1,
0,
1,
2
] |
[
"Gender",
"Authorship",
"Trends",
"of",
"Plastic",
"Surgery",
"Research",
"in",
"the",
"United",
"States",
"An",
"increasing",
"number",
"of",
"women",
"are",
"entering",
"the",
"medical",
"profession,",
"but",
"plastic",
"surgery",
"remains",
"a",
"male",
"-",
"dominated",
"profession,",
"especially",
"within",
"academia.",
"As",
"academic",
"aspirations",
"and",
"advancement",
"depend",
"largely",
"on",
"research",
"productivity,",
"the",
"authors",
"assessed",
"the",
"number",
"of",
"articles",
"authored",
"by",
"women",
"published",
"in",
"the",
"journal",
"Plastic",
"and",
"Reconstructive",
"Surgery.",
"Original",
"articles",
"in",
"Plastic",
"and",
"Reconstructive",
"Surgery",
"published",
"during",
"the",
"years",
"1970,",
"1980,",
"1990,",
"2000,",
"2004,",
"and",
"2014",
"were",
"analyzed.",
"First",
"and",
"senior",
"authors",
"with",
"an",
"M.D.",
"degree",
"and",
"U.S.",
"institutional",
"affiliation",
"were",
"categorized",
"by",
"gender.",
"Authorship",
"trends",
"were",
"compared",
"with",
"those",
"from",
"other",
"specialties.",
"Findings",
"were",
"placed",
"in",
"the",
"context",
"of",
"gender",
"trends",
"among",
"plastic",
"surgery",
"residents",
"in",
"the",
"United",
"States.",
"The",
"percentage",
"of",
"female",
"authors",
"in",
"Plastic",
"and",
"Reconstructive",
"Surgery",
"increased",
"from",
"2.4",
"percent",
"in",
"1970",
"to",
"13.3",
"percent",
"in",
"2014.",
"Over",
"the",
"same",
"time",
"period,",
"the",
"percentage",
"of",
"female",
"plastic",
"surgery",
"residents",
"increased",
"from",
"2.6",
"percent",
"to",
"32.5",
"percent.",
"By",
"2014,",
"there",
"were",
"more",
"female",
"first",
"authors",
"(19.1",
"percent)",
"than",
"senior",
"authors",
"(7.7",
"percent)",
"(p",
"<",
"0.001).",
"As",
"a",
"field,",
"plastic",
"surgery",
"had",
"fewer",
"female",
"authors",
"than",
"other",
"medical",
"specialties",
"including",
"pediatrics,",
"obstetrics",
"and",
"gynecology,",
"general",
"surgery,",
"internal",
"medicine,",
"and",
"radiation",
"oncology",
"(p",
"<",
"0.05).",
"The",
"increase",
"in",
"representation",
"of",
"female",
"authors",
"in",
"plastic",
"surgery",
"is",
"encouraging",
"but",
"lags",
"behind",
"advances",
"in",
"other",
"specialties.",
"Understanding",
"reasons",
"for",
"these",
"trends",
"may",
"help",
"improve",
"gender",
"equity",
"in",
"academic",
"plastic",
"surgery."
] | [
1,
1,
1,
0,
1,
2,
1,
0,
0,
1,
2,
0,
1,
0,
0,
1,
0,
0,
0,
1,
2,
0,
1,
2,
0,
0,
1,
0,
1,
1,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
1,
1,
0,
1,
1,
0,
0,
0,
1,
0,
0,
1,
1,
0,
0,
1,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
1,
1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
1,
2,
0,
0,
0,
1,
2,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
2,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
1,
0,
0,
1,
2,
0,
1,
1,
2,
2,
1,
2,
1,
2,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
0,
1,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
1,
1,
2
] |
[
"REST",
"levels",
"affect",
"the",
"functional",
"expression",
"of",
"voltage",
"dependent",
"calcium",
"channels",
"and",
"the",
"migratory",
"activity",
"in",
"immortalized",
"GnRH",
"neurons",
"The",
"repressor",
"element-1",
"silencing",
"transcription",
"factor",
"(REST)",
"has",
"emerged",
"as",
"a",
"key",
"controller",
"of",
"neuronal",
"differentiation",
"and",
"has",
"been",
"shown",
"to",
"play",
"a",
"critical",
"role",
"in",
"the",
"expression",
"of",
"the",
"neuronal",
"phenotype;",
"however,",
"much",
"has",
"still",
"to",
"be",
"learned",
"about",
"its",
"role",
"at",
"specific",
"developmental",
"stages",
"and",
"about",
"the",
"functional",
"targets",
"affected.",
"Among",
"these",
"targets,",
"calcium",
"signaling",
"mechanisms",
"are",
"critically",
"dependent",
"on",
"the",
"developmental",
"stage",
"and",
"their",
"full",
"expression",
"is",
"a",
"hallmark",
"of",
"the",
"mature,",
"functional",
"neuron.",
"We",
"have",
"analyzed",
"the",
"role",
"played",
"by",
"REST",
"in",
"GN11",
"cells,",
"an",
"immortalized",
"cell",
"line",
"derived",
"from",
"gonadotropin",
"hormone",
"releasing",
"hormone",
"(GnRH)",
"neurons",
"at",
"an",
"early",
"developmental",
"stage,",
"electrically",
"non-excitable",
"and",
"with",
"a",
"strong",
"migratory",
"activity.",
"We",
"show",
"for",
"the",
"first",
"time",
"that",
"functional",
"voltage-dependent",
"calcium",
"channels",
"are",
"expressed",
"in",
"wild",
"type",
"GN11",
"cells;",
"down-regulation",
"of",
"REST",
"by",
"a",
"silencing",
"approach",
"shifts",
"these",
"cells",
"towards",
"a",
"more",
"differentiated",
"phenotype,",
"increasing",
"the",
"functional",
"expression",
"of",
"P",
"/",
"Q-type",
"channels",
"and",
"reducing",
"their",
"migratory",
"potential."
] | [
1,
1,
1,
0,
1,
1,
0,
1,
2,
2,
2,
0,
0,
1,
1,
0,
1,
1,
1,
0,
1,
2,
2,
2,
2,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
2,
1,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
1,
2,
0,
0,
0,
1,
2,
2,
2,
1,
1,
0,
0,
1,
1,
2,
1,
1,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
1,
2,
2,
0,
1,
0,
1,
2,
1,
2,
1,
0,
1,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
1,
1,
0,
1,
0,
1,
2,
0,
0,
0,
1,
1
] |
[
"The",
"knee",
"joint",
"loose",
"body",
"as",
"a",
"source",
"of",
"viable",
"autologous",
"human",
"chondrocytes",
"Loose",
"bodies",
"are",
"fragments",
"of",
"cartilage",
"or",
"bone",
"present",
"in",
"the",
"synovial",
"fluid.",
"In",
"the",
"present",
"study",
"we",
"assessed",
"if",
"loose",
"bodies",
"could",
"be",
"used",
"as",
"a",
"source",
"of",
"autologous",
"human",
"chondrocytes",
"for",
"experimental",
"purposes.",
"Histochemical",
"examination",
"of",
"loose",
"bodies",
"and",
"differential",
"enzymatic",
"digestions",
"were",
"undertaken,",
"the",
"isolated",
"cells",
"were",
"cultured",
"in",
"alginate",
"bead",
"microspheres",
"and",
"immunolocalisations",
"were",
"undertaken",
"for",
"chondrogenic",
"markers",
"such",
"as",
"aggrecan,",
"and",
"type",
"II",
"collagen.",
"Isolated",
"loose",
"body",
"cells",
"had",
"high",
"viability",
"(≥90%",
"viable),",
"expressed",
"chondrogenic",
"markers",
"(aggrecan,",
"type",
"II",
"collagen)",
"but",
"no",
"type",
"I",
"collagen.",
"Loose",
"bodies",
"may",
"be",
"a",
"useful",
"source",
"of",
"autologous",
"chondrocytes",
"of",
"high",
"viability."
] | [
0,
1,
2,
2,
2,
0,
0,
0,
0,
1,
1,
1,
1,
1,
2,
0,
0,
0,
1,
0,
1,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
1,
1,
1,
0,
1,
2,
1,
2,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
0,
1,
2,
1,
0,
1,
0,
0,
0,
1,
1,
0,
0,
1,
0,
1,
2,
2,
0,
1,
2,
1,
0,
0,
1,
0,
0,
0,
1,
1,
1,
1,
2,
2,
0,
1,
1,
2,
2,
1,
2,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
1
] |
[
"Liganded",
"Vitamin",
"D",
"Receptor",
"Through",
"Its",
"Interacting",
"Repressor",
"Inhibits",
"the",
"Expression",
"of",
"Type",
"I",
"Collagen",
"α1",
"Hepatic",
"fibrosis",
"is",
"a",
"reversible",
"process",
"involving",
"plenty",
"of",
"transcription",
"factors",
"and",
"pathways.",
"Vitamin",
"D",
"receptor",
"(VDR)",
"as",
"a",
"member",
"of",
"ligand",
"-",
"induced",
"transcription",
"factors",
"can",
"interact",
"with",
"9-cis",
"retinoid",
"X",
"receptor",
"(RXR)",
"and",
"VDR-interacting",
"repressor",
"(VDIR)",
"to",
"mediate",
"transactivation",
"or",
"transrepression",
"in",
"the",
"absence",
"or",
"in",
"the",
"presence",
"of",
"VDR",
"ligand",
"to",
"regulate",
"the",
"expression",
"of",
"VDR",
"target",
"genes.",
"The",
"active",
"form",
"of",
"vitamin",
"D",
"[1α,25(OH)2D3]",
"can",
"downregulate",
"the",
"expression",
"of",
"type",
"I",
"collagen",
"both",
"α1",
"and",
"α2",
"(COLIα1",
"and",
"COLIα2)",
"in",
"hepatic",
"stellate",
"cells",
"(HSC-T6)",
"in",
"a",
"time-dependent",
"fashion,",
"which",
"provides",
"a",
"new",
"direction",
"for",
"hepatic",
"fibrosis",
"therapy.",
"As",
"one",
"of",
"VDR",
"target",
"genes,",
"rat",
"COLIα1",
"gene",
"contains",
"1αnVDRE",
"(E-box1",
"and",
"E-box2)",
"in",
"its",
"promoter,",
"and",
"unliganded",
"VDR",
"/",
"RXR",
"may",
"bind",
"to",
"1αnVDRE",
"through",
"VDIR",
"to",
"mediate",
"transactivation,",
"whereas",
"liganded",
"VDR",
"/",
"RXR",
"may",
"bind",
"to",
"1αnVDRE",
"through",
"VDIR",
"for",
"transrepression.",
"The",
"results",
"suggested",
"a",
"sort",
"of",
"relying",
"on",
"each",
"other",
"relationship",
"between",
"VDR",
"/",
"RXR",
"and",
"VDIR",
"in",
"regulating",
"the",
"expression",
"of",
"COLIα1",
"gene",
"in",
"HSC-T6",
"cells,",
"which",
"established",
"VDR",
"as",
"a",
"potential",
"target",
"for",
"blocking",
"and",
"even",
"reversing",
"hepatic",
"fibrosis."
] | [
1,
1,
2,
2,
1,
0,
1,
1,
1,
0,
1,
0,
1,
2,
2,
2,
1,
2,
0,
0,
1,
1,
1,
1,
0,
1,
2,
0,
1,
1,
2,
2,
1,
0,
0,
0,
0,
1,
0,
1,
1,
2,
0,
1,
0,
1,
2,
2,
2,
1,
0,
1,
2,
1,
0,
0,
1,
0,
1,
0,
0,
1,
0,
0,
0,
1,
0,
1,
1,
0,
1,
0,
1,
0,
1,
2,
2,
0,
1,
1,
0,
1,
2,
1,
0,
1,
0,
1,
0,
1,
2,
2,
2,
2,
0,
1,
1,
0,
1,
0,
1,
2,
2,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
1,
0,
0,
0,
1,
2,
2,
1,
1,
2,
0,
1,
1,
0,
1,
0,
0,
1,
0,
1,
1,
0,
1,
0,
1,
0,
1,
1,
1,
0,
0,
1,
0,
1,
1,
0,
1,
0,
1,
0,
1,
1,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
1,
0,
1,
0,
1,
0,
1,
0,
1,
2,
0,
1,
2,
0,
0,
1,
0,
0,
1,
1,
0,
1,
0,
0,
1,
1,
2
] |
[
"Treatment",
"with",
"high",
"dose",
"of",
"atorvastatin",
"reduces",
"vascular",
"injury",
"in",
"diabetic",
"rats",
"Previous",
"reports",
"showed",
"conflicting",
"results",
"regarding",
"the",
"treatment",
"effects",
"of",
"statin",
"on",
"Diabetes",
"mellitus",
"(DM).",
"We",
"investigated",
"how",
"treatment",
"with",
"high",
"dose",
"of",
"atorvastatin",
"affects",
"the",
"impaired",
"vascular",
"function",
"in",
"diabetic",
"rats.",
"Atorvastatin",
"(80mg/kg/day,",
"oral",
"gavage,",
"4",
"weeks)",
"or",
"its",
"vehicle",
"was",
"administered",
"to",
"male",
"control",
"or",
"streptozotocin",
"(STZ)-induced",
"diabetic",
"rats.",
"Aortic",
"segments",
"were",
"used",
"to",
"investigate",
"the",
"vascular",
"reactivity,",
"protein",
"expression",
"of",
"cyclooxygenase-2",
"(COX-2)",
"and",
"nicotinamide",
"adenine",
"dinucleotide",
"phosphate",
"oxidase",
"(NADPH",
"oxidase)",
"1",
"(NOX1)",
"and",
"superoxide",
"anions",
"levels.",
"Atorvastatin",
"treatment",
"did",
"not",
"affect",
"glycemia",
"levels.",
"In",
"diabetic",
"rats,",
"the",
"vascular",
"reactivity",
"to",
"phenylephrine",
"increased",
"compared",
"with",
"controls",
"and",
"the",
"atorvastatin",
"treatment",
"reduced",
"this",
"response.",
"Removal",
"of",
"the",
"endothelium",
"increased",
"the",
"response",
"to",
"phenylephrine",
"in",
"control",
"rats,",
"but",
"not",
"in",
"the",
"diabetic",
"group.",
"Atorvastatin",
"increased",
"the",
"endothelial",
"modulation",
"in",
"diabetic",
"rats.",
"L-NAME",
"(100μM)",
"increased",
"the",
"reactivity",
"in",
"all",
"groups,",
"but",
"this",
"effect",
"was",
"greater",
"in",
"atorvastatin",
"-treated",
"diabetic",
"rats.",
"Indomethacin",
"(10μM)",
"and",
"NS398",
"(1μM)",
"decreased",
"the",
"contractile",
"response",
"in",
"diabetic",
"rats",
"and",
"atorvastatin",
"reversed",
"these",
"effects,",
"without",
"changing",
"COX-2",
"expression.",
"Apocynin",
"(30μM)",
"decreased",
"the",
"phenylephrine",
"response",
"in",
"diabetic",
"rats,",
"which",
"also",
"showed",
"increased",
"NOX1",
"and",
"superoxide",
"anions;",
"these",
"effects",
"were",
"prevented",
"by",
"atorvastatin",
"treatment.",
"The",
"results",
"suggest",
"that",
"treatment",
"with",
"high",
"dose",
"of",
"atorvastatin,",
"independent",
"of",
"glycemia,",
"improves",
"endothelial",
"function",
"in",
"aortas",
"from",
"diabetic",
"rats",
"by",
"reducing",
"the",
"constrictor",
"prostanoids",
"derived",
"from",
"COX-2",
"and",
"by",
"reducing",
"the",
"oxidative",
"stress",
"by",
"NADPH",
"oxidase,",
"as",
"well",
"as",
"a",
"possible",
"increasing",
"of",
"nitric",
"oxide",
"participation."
] | [
1,
0,
1,
2,
0,
1,
0,
1,
2,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
2,
1,
0,
0,
0,
1,
0,
1,
2,
0,
1,
0,
0,
1,
1,
2,
0,
1,
1,
1,
0,
1,
2,
0,
1,
0,
0,
1,
0,
1,
0,
1,
2,
0,
1,
1,
1,
1,
1,
2,
0,
0,
0,
0,
0,
1,
2,
1,
2,
0,
1,
1,
0,
1,
2,
2,
2,
2,
2,
2,
2,
1,
0,
1,
2,
1,
1,
1,
0,
0,
0,
1,
2,
0,
1,
1,
0,
1,
2,
0,
1,
1,
0,
0,
1,
0,
0,
1,
1,
1,
0,
1,
1,
0,
0,
1,
1,
0,
1,
0,
1,
0,
1,
2,
0,
0,
0,
0,
1,
2,
1,
1,
0,
1,
2,
0,
1,
1,
1,
0,
1,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
1,
1,
1,
0,
0,
1,
0,
1,
0,
1,
1,
0,
1,
1,
0,
1,
1,
0,
1,
0,
0,
1,
1,
1,
0,
1,
0,
1,
1,
0,
1,
1,
0,
0,
0,
1,
1,
0,
1,
2,
0,
1,
0,
0,
0,
1,
1,
0,
1,
0,
0,
1,
0,
1,
2,
0,
1,
1,
2,
1,
0,
1,
1,
0,
1,
0,
1,
1,
0,
1,
0,
1,
2,
0,
0,
1,
0,
0,
1,
0,
1,
2,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0,
1,
2,
1
] |
[
"Fracture",
"Resistance",
"of",
"Endodontically",
"Treated",
"Teeth",
"Restored",
"With",
"Bulk",
"Fill,",
"Bulk",
"Fill",
"Flowable,",
"Fiber-reinforced,",
"and",
"Conventional",
"Resin",
"Composite",
"The",
"aim",
"of",
"this",
"in",
"vitro",
"study",
"was",
"to",
"evaluate",
"the",
"fracture",
"resistance",
"of",
"endodontically",
"treated",
"teeth",
"restored",
"with",
"different",
"types",
"of",
"restorative",
"resins.",
"Seventy-two",
"sound",
"maxillary",
"premolar",
"teeth",
"were",
"randomly",
"divided",
"into",
"six",
"groups",
"(n=12).",
"The",
"teeth",
"in",
"the",
"first",
"group",
"were",
"left",
"intact",
"and",
"tested",
"as",
"unprepared",
"negative",
"control",
"(group",
"I)",
"specimens.",
"The",
"teeth",
"in",
"the",
"remaining",
"five",
"groups",
"were",
"prepared",
"with",
"MOD",
"cavities",
"and",
"endodontically",
"treated.",
"The",
"teeth",
"in",
"one",
"of",
"the",
"five",
"groups",
"(positive",
"control",
"group",
"II)",
"were",
"unrestored.",
"The",
"rest",
"of",
"the",
"prepared",
"cavities",
"were",
"restored",
"as",
"follows:",
"group",
"III:",
"bulk",
"fill",
"resin",
"composite",
"/",
"Filtek",
"Bulk",
"Fill",
"(3M",
"ESPE);",
"group",
"IV:",
"bulk",
"fill",
"flowable",
"resin",
"composite",
"+",
"nanohybrid",
"/",
"SureFil",
"SDR",
"Flow",
"+",
"Ceram.X",
"Mono",
"(Dentsply);",
"group",
"V:",
"fiber-reinforced",
"composite",
"+",
"posterior",
"resin",
"composite",
"/",
"GC",
"everX",
"posterior",
"+",
"G-aenial",
"posterior",
"(GC",
"Corp",
".);",
"and",
"group",
"VI:",
"nanohybrid",
"resin",
"composite",
"/",
"Tetric",
"N-Ceram",
"(Ivoclar/Vivadent).",
"Each",
"restorative",
"material",
"was",
"used",
"with",
"its",
"respective",
"adhesive",
"system.",
"The",
"restored",
"teeth",
"were",
"stored",
"in",
"distilled",
"water",
"for",
"24",
"hours",
"at",
"37°C",
"and",
"were",
"then",
"thermocycled",
"(5-55°C,",
"1000×).",
"Specimens",
"were",
"subjected",
"to",
"a",
"compressive",
"load",
"until",
"fracture",
"at",
"a",
"crosshead",
"speed",
"of",
"0.5",
"mm/min.",
"The",
"data",
"were",
"analyzed",
"using",
"one-way",
"analysis",
"of",
"variance",
"followed",
"by",
"the",
"post",
"hoc",
"Tukey",
"honestly",
"significantly",
"different",
"test",
"(p<0.05).",
"Sound",
"premolar",
"teeth",
"(group",
"I",
"negative",
"control)",
"showed",
"significantly",
"higher",
"fracture",
"resistance",
"than",
"did",
"the",
"other",
"tested",
"groups",
"(p<0.05).",
"No",
"statistically",
"significant",
"differences",
"were",
"found",
"in",
"the",
"fracture",
"resistance",
"values",
"of",
"the",
"restored",
"groups",
"(groups",
"III,",
"IV,",
"V,",
"and",
"VI)",
"(p>0.05).",
"The",
"lowest",
"values",
"were",
"obtained",
"in",
"the",
"positive",
"control",
"group",
"(group",
"II);",
"these",
"values",
"were",
"significantly",
"lower",
"than",
"those",
"of",
"the",
"other",
"groups",
"(p<0.05).",
"The",
"fracture",
"resistance",
"values",
"of",
"endodontically",
"treated",
"teeth",
"restored",
"with",
"either",
"bulk",
"fill",
"/",
"bulk",
"fill",
"flowable",
"or",
"fiber-reinforced",
"composite",
"were",
"not",
"different",
"from",
"those",
"restored",
"with",
"conventional",
"nanohybrid",
"resin",
"composite."
] | [
1,
2,
0,
1,
2,
2,
1,
0,
1,
2,
1,
2,
2,
1,
0,
1,
2,
2,
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
0,
1,
2,
0,
1,
2,
2,
1,
0,
1,
1,
0,
1,
2,
1,
0,
1,
1,
2,
0,
0,
1,
0,
1,
1,
0,
0,
1,
0,
0,
1,
1,
0,
0,
1,
0,
1,
0,
1,
2,
2,
1,
2,
1,
0,
1,
0,
0,
0,
1,
1,
0,
1,
0,
1,
2,
0,
1,
2,
0,
1,
0,
1,
0,
0,
1,
1,
1,
2,
2,
2,
0,
1,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
2,
1,
2,
2,
2,
0,
1,
2,
2,
1,
2,
1,
2,
1,
2,
2,
2,
2,
0,
1,
0,
1,
2,
2,
0,
1,
2,
1,
1,
2,
1,
2,
0,
1,
2,
2,
0,
1,
2,
2,
0,
1,
2,
1,
2,
0,
0,
1,
2,
1,
2,
2,
0,
1,
2,
1,
1,
1,
2,
0,
1,
0,
0,
0,
1,
2,
0,
1,
1,
0,
1,
0,
1,
2,
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
0,
0,
1,
2,
0,
1,
0,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
0,
1,
2,
2,
2,
1,
2,
0,
1,
2,
2,
0,
0,
1,
1,
0,
1,
2,
2,
1,
2,
1,
2,
0,
1,
2,
1,
2,
0,
0,
0,
1,
1,
2,
0,
1,
2,
2,
2,
0,
1,
0,
0,
1,
2,
1,
0,
0,
1,
1,
0,
2,
1,
0,
0,
1,
0,
0,
1,
1,
0,
1,
0,
0,
1,
2,
1,
0,
2,
0,
1,
0,
1,
2,
0,
0,
0,
0,
1,
1,
0,
0,
1,
2,
1,
0,
1,
2,
2,
1,
0,
0,
1,
2,
0,
1,
2,
2,
0,
1,
2,
0,
1,
1,
0,
0,
1,
0,
1,
1,
2,
2
] |
[
"The",
"phonetic",
"landscape",
"in",
"infant",
"consonant",
"perception",
"is",
"an",
"uneven",
"terrain",
"Previous",
"research",
"revealing",
"universal",
"biases",
"in",
"infant",
"vowel",
"perception",
"forms",
"the",
"basis",
"of",
"the",
"Natural",
"Referent",
"Vowel",
"(NRV)",
"framework",
"(Polka",
"&",
"Bohn,",
"2011).",
"To",
"explore",
"the",
"feasibility",
"of",
"extending",
"this",
"framework",
"to",
"consonant",
"manner",
"perception,",
"we",
"investigated",
"perception",
"of",
"the",
"stop",
"vs.",
"fricative",
"consonant",
"contrast",
"/b/-/v/",
"to",
"test",
"the",
"hypothesis",
"that",
"young",
"infants",
"will",
"display",
"a",
"perceptual",
"bias",
"grounded",
"in",
"the",
"acoustic",
"-",
"phonetic",
"properties",
"of",
"these",
"sounds.",
"We",
"examined",
"perception",
"of",
"stop-initial",
"/bas/",
"and",
"fricative-initial",
"/vas/",
"syllables",
"in",
"English",
"-",
"learning",
"and",
"French",
"-",
"learning",
"5-",
"to",
"6-month-olds.",
"The",
"/b/",
"and",
"/v/",
"sounds",
"distinguish",
"words",
"in",
"English",
"and",
"French",
"but",
"have",
"different",
"distributional",
"patterns;",
"in",
"spoken",
"English",
"/b/",
"occurs",
"more",
"frequently",
"than",
"/v/",
"whereas",
"in",
"spoken",
"French",
"/v/",
"occurs",
"more",
"frequently",
"than",
"/b/.",
"A",
"perceptual",
"bias",
"favoring",
"/b/",
"over",
"/v/",
"emerged",
"in",
"two",
"experiments.",
"In",
"Experiment",
"1,",
"a",
"directional",
"asymmetry",
"was",
"observed",
"in",
"discrimination;",
"infants",
"noticed",
"when",
"/vas/",
"changed",
"to",
"/bas/",
"but",
"not",
"when",
"/bas/",
"changed",
"to",
"/vas/.",
"In",
"Experiment",
"2,",
"a",
"robust",
"listening",
"preference",
"favoring",
"stop-initial",
"/bas/",
"was",
"evident",
"in",
"responses",
"from",
"the",
"same",
"infants.",
"This",
"is",
"the",
"first",
"study",
"to",
"show",
"a",
"perceptual",
"bias",
"related",
"to",
"consonant",
"manner",
"and",
"to",
"directly",
"measure",
"a",
"consonant",
"perception",
"bias",
"within",
"the",
"same",
"infants.",
"These",
"data",
"encourage",
"further",
"efforts",
"to",
"extend",
"the",
"NRV",
"principles",
"to",
"perception",
"of",
"consonant",
"manner.",
"These",
"findings",
"indicate",
"that",
"we",
"need",
"to",
"reform",
"our",
"view",
"of",
"infant",
"speech",
"perception",
"to",
"accommodate",
"the",
"fact",
"that",
"both",
"discrimination",
"abilities",
"and",
"biases",
"shape",
"speech",
"perception",
"during",
"infancy."
] | [
0,
1,
0,
0,
1,
1,
1,
0,
0,
1,
2,
0,
1,
0,
0,
1,
0,
1,
1,
1,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
1,
0,
0,
1,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
1,
1,
0,
0,
0,
1,
0,
1,
0,
0,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
1,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
1,
2,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
1,
1,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
1,
1,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
1,
0,
1
] |
[
"Propensity",
"-",
"matched",
"Analysis",
"of",
"Outcomes",
"and",
"Hospital",
"Charges",
"for",
"Anterior",
"Versus",
"Posterior",
"Cervical",
"Fusion",
"for",
"Cervical",
"Spondylotic",
"Myelopathy",
"Retrospective",
"analysis",
"of",
"data",
"from",
"the",
"Nationwide",
"Inpatient",
"Sample,",
"a",
"nationally",
"representative,",
"all-payer",
"database",
"of",
"inpatient",
"diagnoses",
"and",
"procedures",
"in",
"the",
"United",
"States.",
"The",
"objective",
"of",
"this",
"study",
"is",
"to",
"compare",
"anterior",
"cervical",
"fusion",
"(ACF)",
"to",
"posterior",
"cervical",
"fusion",
"(PCF)",
"in",
"the",
"treatment",
"of",
"cervical",
"spondylotic",
"myelopathy",
"(CSM).",
"Previous",
"studies",
"used",
"retrospective",
"single",
"-",
"institution",
"level",
"data",
"to",
"quantify",
"outcomes",
"for",
"CSM",
"patients",
"fusion.",
"It",
"is",
"unclear",
"whether",
"ACF",
"or",
"PCF",
"is",
"superior",
"with",
"regards",
"to",
"charges",
"or",
"outcomes",
"for",
"the",
"treatment",
"of",
"CSM.",
"We",
"used",
"Nationwide",
"Inpatient",
"Sample",
"data",
"to",
"compare",
"ACF",
"to",
"PCF",
"in",
"the",
"management",
"of",
"CSM.",
"All",
"patients",
"18",
"years",
"or",
"older",
"with",
"a",
"diagnosis",
"of",
"CSM",
"between",
"1998",
"and",
"2011",
"were",
"included.",
"ACF",
"patients",
"were",
"matched",
"to",
"PCF",
"patients",
"using",
"propensity",
"scores",
"based",
"on",
"patient",
"characteristics",
"(number",
"of",
"levels",
"fused,",
"spine",
"alignment,",
"comorbidities),",
"hospital",
"characteristics,",
"and",
"patient",
"demographics.",
"Multivariable",
"regression",
"was",
"used",
"to",
"measure",
"the",
"effect",
"of",
"treatment",
"assignment",
"on",
"in-",
"hospital",
"charges,",
"length",
"of",
"hospital",
"stay,",
"in-hospital",
"mortality,",
"discharge",
"disposition,",
"and",
"dysphagia",
"diagnosis.",
"From",
"1998",
"to",
"2011,",
"we",
"identified",
"109,728",
"hospitalizations",
"with",
"a",
"CSM",
"diagnosis.",
"Of",
"these",
"patients,",
"45,629",
"(41.6%)",
"underwent",
"ACF",
"and",
"14,439",
"(13.2%)",
"underwent",
"PCF.",
"The",
"PCF",
"cohort",
"incurred",
"an",
"average",
"of",
"$41,683",
"more",
"in-hospital",
"charges",
"(P<0.001,",
"inflation",
"adjusted",
"to",
"2011",
"dollars)",
"and",
"remained",
"in",
"hospital",
"an",
"average",
"of",
"2.4",
"days",
"longer",
"(P<0.001)",
"than",
"the",
"ACF",
"cohort.",
"The",
"ACF",
"cohort",
"was",
"just",
"as",
"likely",
"to",
"die",
"in",
"the",
"hospital",
"[odds",
"ratio",
"0.91;",
"95%",
"confidence",
"interval",
"(CI),",
"0.68-1.2],",
"3.0",
"times",
"more",
"likely",
"to",
"be",
"discharged",
"to",
"home",
"or",
"self-care",
"(95%",
"CI,",
"2.9-3.2),",
"and",
"2.5",
"times",
"more",
"likely",
"to",
"experience",
"dysphagia",
"(95%",
"CI,",
"2.0-3.1)",
"than",
"the",
"PCF",
"cohort.",
"In",
"treating",
"CSM,",
"ACF",
"led",
"to",
"lower",
"hospital",
"charges,",
"shorter",
"hospital",
"stays,",
"and",
"an",
"increased",
"likelihood",
"of",
"being",
"discharged",
"to",
"home",
"relative",
"to",
"PCF."
] | [
1,
0,
1,
1,
0,
1,
0,
1,
2,
0,
1,
0,
1,
2,
2,
0,
1,
2,
2,
1,
1,
0,
1,
0,
0,
1,
1,
1,
0,
0,
0,
1,
2,
0,
1,
1,
2,
2,
0,
0,
1,
2,
0,
0,
0,
0,
1,
0,
0,
1,
1,
2,
2,
1,
0,
1,
2,
2,
1,
0,
0,
1,
0,
1,
2,
2,
1,
1,
1,
1,
1,
1,
0,
1,
1,
2,
0,
1,
1,
0,
1,
1,
1,
0,
0,
1,
0,
1,
0,
1,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
1,
0,
1,
0,
0,
1,
1,
1,
1,
0,
1,
1,
0,
1,
0,
0,
1,
0,
1,
0,
1,
1,
2,
2,
2,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
1,
0,
1,
0,
1,
1,
0,
1,
2,
0,
0,
1,
2,
1,
2,
2,
2,
0,
0,
1,
1,
1,
0,
1,
2,
1,
2,
0,
1,
0,
1,
0,
1,
0,
1,
1,
0,
0,
1,
2,
1,
2,
2,
2,
1,
2,
1,
2,
0,
1,
1,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
1,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
1,
0,
0,
1,
1,
2,
0,
1,
1,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
1,
1,
0,
0,
0,
1,
1,
0,
1,
1,
0,
0,
0,
0,
0,
1,
0,
0,
1,
1,
2,
0,
0,
1,
2,
1,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
1,
0,
0,
0,
1,
1,
0,
1,
1,
1,
0,
0,
1,
1,
2,
1,
1,
2,
0,
0,
1,
1,
0,
0,
1,
2,
2,
1,
0,
1
] |
[
"Readers'",
"panel",
"-",
"Should",
"nurses",
"be",
"prosecuted",
"if",
"they",
"fail",
"to",
"report",
"child",
"abuse?",
"Our",
"experts",
"consider",
"a",
"hot",
"topic",
"of",
"the",
"day."
] | [
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
0,
1,
2,
2,
0,
1,
0,
0,
0,
1,
0,
0,
0
] |
[
"Development",
"of",
"an",
"Evaluation",
"Device",
"for",
"Phagocytic",
"Activity",
"of",
"New",
"Phagocytes",
"Using",
"Simple",
"and",
"pH-sensitive",
"Particles",
"that",
"Do",
"Not",
"Require",
"Pre-treatment",
"Phagocytic",
"activity",
"is",
"affected",
"by",
"a",
"number",
"of",
"different",
"stress",
"and",
"age",
"-dependent",
"factors.",
"An",
"easy",
"measurement",
"of",
"phagocytic",
"activity",
"is",
"thought",
"to",
"allow",
"an",
"indicator",
"of",
"an",
"individual",
"'s",
"health.",
"In",
"this",
"study,",
"we",
"investigated",
"conditions",
"of",
"measurement",
"to",
"easily",
"evaluate",
"the",
"activity",
"of",
"phagocytosis",
"of",
"phagocytic",
"cells",
"(macrophages",
"and",
"neutrophils)",
"using",
"an",
"easy-to-use",
"prototype,",
"which",
"was",
"improved",
"from",
"the",
"device",
"by",
"Hamamatsu",
"Photonics",
"K.K.,",
"to",
"detect",
"neutrophil",
"activity",
"using",
"subtle",
"fluorescence.",
"pH-sensitive",
"fluorescent",
"particles",
"(pHrodo-Green",
"E.",
"coli",
"Bio",
"particles,",
"GE",
"particles)",
"were",
"added",
"to",
"mouse",
"-derived",
"macrophage",
"cell",
"lines",
"(J774.1)",
"and",
"then",
"incubated",
"for",
"2",
"h",
"at",
"37°C.",
"For",
"negative",
"control,",
"the",
"phagocytosis",
"inhibitor",
"cytochalasin",
"D",
"(CyD),",
"was",
"added",
"prior",
"to",
"culture.",
"Next,",
"fluorescence",
"intensity",
"was",
"measured",
"by",
"the",
"Prototype",
"to",
"evaluate",
"the",
"phagocytic",
"activity",
"of",
"macrophages",
"and",
"neutrophils.",
"Phagocytosis",
"was",
"also",
"confirmed",
"by",
"flow",
"cytometry.",
"The",
"Prototype",
"detected",
"a",
"steady",
"fluorescence",
"increase",
"in",
"5",
"sec",
"in",
"J774.1",
"after",
"phagocytosis,",
"using",
"GE",
"particles",
"as",
"a",
"negative",
"control",
"in",
"the",
"presence",
"of",
"CyD.",
"Furthermore,",
"detection",
"was",
"possible",
"at",
"10(4)",
"cells/test,",
"a",
"concentration",
"where",
"the",
"flow",
"cytometer",
"had",
"difficulty",
"for",
"detection.",
"The",
"Prototype",
"enables",
"measurement",
"of",
"the",
"phagocytic",
"activity",
"within",
"a",
"short",
"period",
"of",
"time,",
"even",
"with",
"a",
"small",
"sample",
"amount,",
"thus",
"establishing",
"the",
"basic",
"conditions",
"of",
"measurements",
"of",
"phagocytosis."
] | [
1,
0,
0,
1,
1,
0,
1,
1,
0,
0,
1,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
1,
0,
1,
2,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
2,
0,
0,
1,
1,
0,
0,
1,
1,
2,
2,
1,
2,
2,
2,
2,
1,
2,
0,
0,
0,
1,
0,
1,
2,
2,
1,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
0,
1,
1,
1,
2,
1,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
1,
0,
1,
1,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
1,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
0,
1
] |
[
"Survival",
"of",
"ovarian",
"cancer",
"patients",
"in",
"Denmark:",
"Results",
"from",
"the",
"Danish",
"gynaecological",
"cancer",
"group",
"(DGCG)",
"database,",
"1995-2012",
"Ovarian",
"cancer",
"has",
"a",
"high",
"mortality",
"rate,",
"especially",
"in",
"Denmark",
"where",
"mortality",
"rates",
"have",
"been",
"reported",
"higher",
"than",
"in",
"adjacent",
"countries",
"with",
"similar",
"demographics.",
"This",
"study",
"therefore",
"examined",
"recent",
"survival",
"and",
"mortality",
"among",
"Danish",
"ovarian",
"cancer",
"patients",
"over",
"an",
"18-year",
"study",
"period.",
"This",
"nationwide",
"registry-based",
"observational",
"study",
"used",
"data",
"from",
"the",
"Danish",
"Gynecology",
"Cancer",
"Database,",
"Danish",
"Pathology",
"Registry,",
"and",
"Danish",
"National",
"Patient",
"Registry.",
"All",
"patients",
"with",
"ovarian",
"cancer",
"diagnosed",
"between",
"1995",
"and",
"2012",
"were",
"included",
"in",
"the",
"study.",
"The",
"data",
"sources",
"were",
"linked",
"via",
"the",
"patients",
"'",
"personal",
"identification",
"number",
"and",
"the",
"analyses",
"included",
"data",
"on",
"cancer",
"stage,",
"age,",
"survival,",
"surgery",
"status",
"and",
"comorbidity.",
"The",
"computed",
"outcome",
"measures",
"were",
"age-adjusted",
"mortality",
"rates",
"and",
"age-adjusted",
"overall",
"and",
"relative",
"survival",
"rates",
"for",
"one",
"and",
"five",
"years.",
"We",
"identified",
"9972",
"patients",
"diagnosed",
"with",
"ovarian",
"cancer",
"in",
"the",
"period",
"1995-2012.",
"The",
"absolute",
"one-year",
"mortality",
"rate",
"decreased",
"from",
"42.8",
"(CI",
"40.3-45.6)",
"in",
"1995-1999",
"to",
"28.3",
"(CI",
"25.9-30.9)",
"in",
"2010-2012,",
"and",
"the",
"five-year",
"mortality",
"rate",
"decreased",
"from",
"28.2",
"(CI",
"27.0-29.5)",
"in",
"1995-1999",
"to",
"23.9",
"(CI",
"22.9-25.0)",
"in",
"2005-2009.",
"After",
"stratification",
"by",
"age,",
"comorbidity",
"and",
"cancer",
"stage,",
"the",
"decrease",
"in",
"one-year",
"mortality",
"was",
"most",
"substantial",
"in",
"the",
"65-74",
"year",
"old",
"age",
"group",
"41.1",
"(CI",
"38.8-43.5)",
"to",
"26.5",
"(CI",
"24.4-28.7)",
"and",
"for",
"stage",
"III",
"39.1",
"(CI",
"35.1-43.6)",
"to",
"22.9",
"(CI",
"19.9-26.5)",
"and",
"stage",
"IV",
"91.3",
"(CI",
"80.8-103.2)",
"to",
"41.9",
"(CI",
"35.5-49.5).",
"For",
"overall",
"survival,",
"we",
"showed",
"an",
"increase",
"in",
"one-year",
"survival",
"from",
"68%",
"(CI",
"66-69%)",
"in",
"1995-1999",
"to",
"76%",
"(CI",
"74-78%)",
"in",
"2010-2012",
"and",
"an",
"increase",
"in",
"five-year",
"survival",
"from",
"33%",
"(CI",
"32-35%)",
"in",
"1995-1999",
"to",
"36%",
"(CI",
"34-38%)",
"in",
"2005-2009.",
"Relative",
"survival",
"showed",
"similar",
"increases",
"through",
"the",
"period.",
"Ovarian",
"cancer",
"survival",
"in",
"Denmark",
"has",
"improved",
"substantially",
"from",
"1995",
"to",
"2012,",
"bringing",
"Denmark",
"closer",
"to",
"the",
"standards",
"set",
"by",
"adjacent",
"countries."
] | [
1,
0,
1,
2,
1,
0,
1,
0,
0,
0,
1,
2,
2,
2,
1,
2,
0,
1,
2,
0,
0,
1,
2,
2,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
2,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0,
1,
0,
1,
2,
2,
1,
0,
0,
0,
0,
0,
0,
1,
2,
1,
2,
0,
0,
0,
0,
1,
2,
2,
2,
1,
2,
2,
0,
1,
2,
2,
2,
0,
1,
0,
1,
2,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
2,
2,
0,
0,
1,
2,
2,
0,
1,
1,
0,
1,
1,
2,
0,
1,
0,
0,
1,
2,
0,
1,
2,
2,
0,
0,
1,
0,
1,
2,
2,
0,
1,
2,
2,
2,
0,
0,
0,
1,
2,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
2,
2,
1,
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
2,
2,
1,
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
2,
2,
1,
0,
1,
2,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
0,
0,
0,
1,
0,
0,
0,
1,
2,
0,
1,
0,
0,
0,
1,
0,
0,
1,
2,
0,
1,
0,
0,
0,
1,
0,
0,
1,
2,
0,
0,
0,
1,
0,
1,
2,
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
2,
0,
0,
1,
0,
0,
0,
1,
2,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2
] |
[
"Cavity",
"partition",
"and",
"functionalization",
"of",
"a",
"[2+3]",
"organic",
"molecular",
"cage",
"by",
"inserting",
"polar",
"P[double",
"bond,",
"length",
"as",
"m-dash]O",
"bonds",
"The",
"cavity",
"of",
"a",
"[2+3]",
"organic",
"molecular",
"cage",
"was",
"partitioned",
"and",
"functionalized",
"by",
"inserting",
"inner-directed",
"P[double",
"bond,",
"length",
"as",
"m-dash]O",
"bonds,",
"which",
"shows",
"CO2",
"capture",
"and",
"CH4",
"exclusion",
"due",
"to",
"the",
"size",
"-",
"matching",
"and",
"polarity",
"effects.",
"Computational",
"results",
"demonstrate",
"that",
"the",
"successful",
"segmentation",
"via",
"polar",
"P[double",
"bond,",
"length",
"as",
"m-dash]O",
"bonds",
"facilitates",
"the",
"CO2",
"molecules",
"to",
"reside",
"selectively",
"inside",
"the",
"cavity."
] | [
1,
1,
0,
1,
0,
0,
0,
1,
2,
2,
0,
1,
1,
2,
2,
2,
2,
2,
2,
0,
1,
0,
0,
0,
1,
2,
2,
0,
1,
0,
1,
0,
1,
1,
1,
2,
2,
2,
2,
2,
0,
0,
1,
0,
0,
1,
1,
0,
0,
0,
1,
0,
1,
0,
1,
1,
1,
1,
1,
0,
0,
1,
1,
0,
1,
2,
2,
2,
2,
2,
2,
0,
0,
1,
1,
0,
1,
1,
0,
0,
1
] |
[
"Succession",
"Planning",
"and",
"Financial",
"Performance:",
"Does",
"Competition",
"Matter?",
"Succession",
"planning",
"has",
"been",
"defined",
"as",
"the",
"process",
"by",
"which",
"one",
"or",
"more",
"successors",
"are",
"identified",
"for",
"key",
"positions,",
"development",
"activities",
"are",
"planned",
"for",
"identified",
"successors,",
"or",
"both.",
"Limited",
"research",
"exists",
"pertaining",
"to",
"the",
"relationship",
"between",
"hospital",
"succession",
"planning",
"and",
"financial",
"performance,",
"particularly",
"in",
"the",
"context",
"of",
"market",
"competition.",
"We",
"used",
"the",
"resource-based",
"view",
"framework",
"to",
"analyze",
"the",
"differential",
"effect",
"of",
"succession",
"planning",
"on",
"hospitals",
"'",
"financial",
"performance",
"based",
"on",
"market",
"competition.",
"According",
"to",
"RBV,",
"organizations",
"can",
"achieve",
"higher",
"performance",
"by",
"using",
"their",
"superior",
"resources",
"and",
"capabilities.",
"We",
"used",
"a",
"panel",
"design",
"consisting",
"of",
"a",
"national",
"sample",
"of",
"hospitals",
"in",
"the",
"United",
"States",
"for",
"2006-2010.",
"We",
"analyzed",
"data",
"using",
"multivariate",
"linear",
"regression",
"with",
"facility",
"random",
"effects",
"and",
"year",
"and",
"state",
"fixed",
"effects.",
"The",
"sample",
"included",
"22,717",
"hospital",
"-",
"year",
"observations;",
"more",
"than",
"one",
"half",
"of",
"the",
"hospitals",
"(55.4%)",
"had",
"a",
"succession",
"planning",
"program.",
"The",
"study",
"found",
"a",
"positive",
"relationship",
"between",
"the",
"presence",
"of",
"succession",
"planning",
"and",
"financial",
"performance",
"(β",
"=",
"1.41,",
"p",
"<",
".01),",
"which",
"was",
"stronger",
"in",
"competitive",
"market",
"s",
"(β",
"=",
"2.31,",
"p",
"=",
".03)",
"than",
"in",
"monopolistic",
"markets",
"(β",
"=",
"1.06,",
"p",
"=",
".01).",
"Hospitals",
"can",
"use",
"these",
"results",
"to",
"make",
"informed",
"decisions",
"about",
"investing",
"in",
"succession",
"planning",
"programs",
"on",
"the",
"basis",
"of",
"competition",
"in",
"their",
"market."
] | [
1,
2,
0,
1,
1,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
1,
1,
0,
1,
0,
1,
1,
0,
0,
1,
1,
0,
0,
0,
0,
1,
0,
1,
1,
2,
0,
1,
1,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
1,
2,
1,
0,
1,
0,
0,
1,
2,
1,
2,
0,
1,
0,
1,
1,
0,
0,
1,
1,
0,
0,
1,
1,
0,
0,
1,
1,
0,
0,
0,
1,
1,
0,
1,
0,
0,
0,
1,
2,
0,
0,
0,
1,
2,
0,
1,
0,
0,
1,
2,
0,
0,
0,
1,
1,
0,
1,
2,
2,
0,
1,
2,
2,
0,
1,
0,
1,
1,
2,
0,
1,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
1,
1,
0,
0,
1,
0,
1,
2,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
1,
0,
0,
1
] |
[
"\"",
"Bridge",
"Proteins",
"\"",
"Link",
"Inflammation",
"and",
"Metabolic",
"Diseases:",
"Potential",
"Targets",
"for",
"Therapeutics",
"Clinical",
"observations",
"support",
"the",
"postulate",
"that",
"chronic",
"low",
"-",
"grade",
"inflammation",
"underlies",
"metabolic",
"diseases",
"and",
"inflammatory",
"mediators",
"can",
"trigger",
"some",
"metabolic",
"diseases.",
"In",
"disorder",
"condition,",
"what",
"is",
"the",
"first",
"one:",
"metabolic",
"diseases",
"cause",
"inflammation",
"or",
"conversely?",
"This",
"\"chicken",
"or",
"egg\"",
"type",
"question",
"was",
"hard",
"to",
"answer.",
"However,",
"instead",
"of",
"focusing",
"on",
"this",
"difficult",
"issue,",
"we",
"should",
"ask",
"another",
"challenging",
"question:",
"what",
"are",
"the",
"links",
"between",
"inflammation",
"and",
"metabolic",
"diseases?",
"Seizing",
"the",
"key",
"from",
"this",
"chaos",
"may",
"be",
"the",
"best",
"way",
"to",
"solve",
"the",
"problem",
"and",
"break",
"the",
"cycle.",
"To",
"answer",
"this",
"question,",
"we",
"review",
"the",
"regulators",
"(such",
"as",
"NF-κB,",
"PPARs,",
"mTOR,",
"and",
"STAT3)",
"that",
"have",
"important",
"roles",
"in",
"both",
"metabolism",
"and",
"inflammation.",
"These",
"\"",
"bridge",
"proteins",
"\"",
"that",
"link",
"metabolic",
"diseases",
"and",
"inflammation",
"not",
"only",
"increase",
"our",
"understanding",
"of",
"these",
"two",
"diseases,",
"but",
"also",
"provide",
"potential",
"targets",
"for",
"therapeutics",
"and",
"practical",
"clinical",
"applications."
] | [
0,
1,
2,
0,
0,
1,
0,
1,
2,
0,
1,
0,
1,
1,
2,
0,
0,
0,
0,
1,
1,
0,
1,
1,
0,
1,
2,
0,
1,
2,
0,
1,
0,
1,
2,
0,
1,
1,
0,
0,
0,
0,
0,
1,
2,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
1,
1,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
2,
0,
0,
0,
1,
2,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
1
] |
[
"Lipidomic",
"Signatures",
"and",
"Associated",
"Transcriptomic",
"Profiles",
"of",
"Clear",
"Cell",
"Renal",
"Cell",
"Carcinoma",
"Renal",
"cell",
"carcinoma",
"(RCC)",
"is",
"the",
"most",
"common",
"histological",
"type",
"of",
"adult",
"kidney",
"cancer.",
"In",
"this",
"study,",
"we",
"obtained",
"lipidomic",
"profiles",
"of",
"clear",
"cell",
"RCC",
"(ccRCC),",
"a",
"major",
"RCC",
"subtype,",
"by",
"performing",
"a",
"lipidomic",
"analysis",
"of",
"specimens",
"of",
"cancerous",
"tissue",
"and",
"the",
"surrounding",
"normal",
"renal",
"cortex",
"obtained",
"from",
"the",
"same",
"patients",
"(N",
"=",
"49).",
"We",
"also",
"compared",
"the",
"lipidomic",
"profiles",
"with",
"the",
"lipogenic",
"transcriptome",
"of",
"specimens",
"of",
"cancerous",
"tissue",
"and",
"the",
"surrounding",
"normal",
"renal",
"cortex",
"for",
"an",
"additional",
"set",
"of",
"patient",
"samples",
"(N",
"=",
"95).",
"Overall,",
"we",
"detected",
"326",
"lipids,",
"including",
"phospholipids,",
"sphingolipids,",
"neutral",
"lipids,",
"and",
"eicosanoids.",
"The",
"levels",
"of",
"more",
"than",
"70%",
"of",
"the",
"detected",
"lipids",
"were",
"significantly",
"different",
"(P",
"<",
"0.01,",
"corrected",
"by",
"the",
"false",
"discovery",
"rate).",
"The",
"cancerous",
"tissue",
"was",
"distinguished",
"by",
"higher",
"levels",
"of",
"ether-type",
"phospholipids,",
"cholesterol",
"esters,",
"and",
"triacylglycerols,",
"as",
"well",
"as",
"by",
"lower",
"levels",
"of",
"phospholipids",
"(except",
"for",
"phosphatidylcholines)",
"and",
"polyunsaturated",
"fatty",
"acids.",
"Characteristic",
"changes",
"in",
"the",
"levels",
"of",
"mRNAs",
"and",
"metabolites",
"suggested",
"that",
"the",
"phosphatidylethanolamine",
"(PE)",
"synthesis",
"pathway",
"is",
"suppressed",
"in",
"ccRCC",
"and",
"associated",
"with",
"cell",
"proliferation.",
"The",
"present",
"study",
"represents",
"the",
"lipidomic",
"profiles",
"of",
"ccRCC,",
"which",
"provides",
"novel",
"information",
"about",
"the",
"metabolic",
"changes",
"in",
"renal",
"cancerous",
"tissue",
"and",
"RCC",
"pathophysiology."
] | [
1,
2,
0,
0,
1,
2,
0,
1,
2,
2,
2,
2,
1,
2,
2,
1,
0,
0,
0,
0,
1,
2,
0,
1,
1,
2,
0,
0,
1,
0,
0,
1,
2,
0,
1,
2,
2,
1,
0,
0,
1,
1,
0,
0,
0,
1,
2,
0,
1,
0,
1,
2,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
1,
0,
1,
0,
1,
2,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
1,
1,
2,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
2,
1,
2,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
1,
2,
2,
2,
0,
1,
0,
1,
0,
0,
0,
1,
2,
0,
0,
1,
0,
0,
1,
2,
0,
1,
0,
0,
0,
0,
0,
0,
1,
1,
0,
1,
1,
2,
0,
1,
1
] |
[
"Bone",
"-",
"Albumin",
"filling",
"decreases",
"donor",
"site",
"morbidity",
"and",
"enhances",
"bone",
"formation",
"after",
"anterior",
"cruciate",
"ligament",
"reconstruction",
"with",
"bone-patellar",
"tendon-bone",
"autografts",
"Donor",
"site",
"pain",
"affects",
"32-43",
"%",
"of",
"patients",
"after",
"anterior",
"cruciate",
"ligament",
"surgery",
"when",
"the",
"autograft",
"is",
"freshly",
"harvested",
"bone-patellar",
"tendon-bone",
"tissue.",
"Our",
"aim",
"was",
"to",
"compare",
"functional",
"and",
"morphological",
"differences",
"between",
"donor",
"sites",
"with",
"and",
"without",
"serum",
"albumin",
"-",
"coated",
"bone",
"allograft",
"filling.",
"After",
"harvesting",
"and",
"implanting",
"the",
"graft,",
"the",
"tibia",
"site",
"was",
"filled",
"with",
"either",
"fresh",
"autologous",
"cancellous",
"bone",
"enhanced",
"with",
"albumin",
"-",
"coated",
"allograft",
"or",
"autologous",
"bone",
"alone.",
"The",
"patella",
"site",
"was",
"filled",
"either",
"with",
"albumin",
"-",
"coated",
"allograft",
"or",
"with",
"blood",
"clot.",
"Knee",
"function",
"was",
"evaluated",
"by",
"the",
"VISA,",
"Lysholm",
"and",
"IKDC",
"scores",
"and",
"a",
"visual",
"analog",
"scale",
"of",
"pain",
"during",
"standing,",
"kneeling",
"and",
"crouching",
"after",
"six",
"weeks",
"and",
"six",
"months.",
"Computed",
"tomography",
"was",
"performed",
"at",
"six",
"months",
"for",
"morphological",
"evaluation.",
"At",
"six",
"weeks,",
"both",
"groups",
"were",
"still",
"recovering",
"from",
"surgery",
"and",
"the",
"overall",
"knee",
"function",
"was",
"still",
"impaired",
"but",
"the",
"functional",
"scores",
"were",
"significantly",
"higher",
"in",
"the",
"Bone",
"-",
"Albumin",
"group.",
"The",
"pain",
"with",
"crouching",
"and",
"kneeling",
"was",
"also",
"lower",
"as",
"compared",
"to",
"controls.",
"At",
"six",
"months,",
"the",
"knee",
"function",
"scores",
"were",
"close",
"to",
"normal,",
"with",
"a",
"slight",
"decrease",
"in",
"the",
"controls.",
"Pain",
"at",
"kneeling",
"was",
"still",
"prominent",
"in",
"the",
"controls,",
"but",
"significantly",
"lower",
"in",
"the",
"Bone",
"-",
"Albumin",
"group.",
"Computed",
"tomography",
"showed",
"significantly",
"smaller",
"bone",
"defects",
"and",
"higher",
"bone",
"density",
"in",
"the",
"Bone",
"-",
"Albumin",
"group.",
"Results",
"from",
"the",
"present",
"study",
"indicate",
"that",
"donor",
"site",
"pain,",
"a",
"disturbing",
"long-term",
"side",
"effect",
"of",
"bone-patellar",
"tendon-bone",
"surgery,",
"is",
"significantly",
"reduced",
"if",
"bone",
"buildup",
"in",
"the",
"patella",
"and",
"the",
"tibia",
"is",
"augmented",
"by",
"serum",
"albumin",
"-",
"coated",
"bone",
"allografts."
] | [
1,
0,
1,
1,
1,
1,
2,
1,
0,
1,
1,
2,
0,
1,
2,
2,
1,
0,
1,
2,
1,
1,
2,
1,
0,
0,
0,
0,
1,
0,
1,
2,
2,
1,
0,
0,
1,
0,
1,
1,
1,
2,
2,
0,
0,
0,
0,
1,
1,
0,
1,
1,
0,
1,
2,
0,
0,
0,
1,
2,
0,
1,
1,
1,
1,
0,
1,
0,
1,
0,
1,
0,
1,
1,
0,
0,
0,
0,
1,
1,
1,
2,
1,
0,
1,
0,
1,
1,
0,
1,
1,
0,
0,
1,
1,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
1,
2,
1,
1,
0,
1,
0,
0,
1,
1,
0,
1,
2,
0,
0,
1,
2,
2,
2,
2,
0,
1,
1,
0,
1,
0,
0,
1,
0,
0,
1,
1,
2,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
1,
0,
1,
0,
0,
1,
2,
1,
0,
0,
1,
1,
1,
0,
0,
1,
0,
0,
1,
1,
0,
1,
2,
0,
0,
1,
0,
1,
1,
0,
1,
0,
1,
0,
1,
0,
0,
1,
0,
1,
0,
1,
0,
0,
1,
0,
1,
1,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
1,
1,
0,
1,
0,
0,
1,
0,
0,
1,
0,
1,
2,
0,
0,
1,
0,
1,
1,
1,
2,
0,
1,
1,
1,
1,
0,
1,
1,
2,
0,
0,
1,
0,
1,
1,
1,
0,
0,
0,
1,
1,
0,
1,
2,
1,
0,
0,
1,
1,
2,
0,
1,
2,
1,
0,
1,
1,
0,
1,
0,
0,
0,
1,
0,
0,
1,
0,
0,
0,
1,
2,
0,
1,
1,
1
] |
[
"Graphene",
"oxide",
"/",
"multi-walled",
"carbon",
"nanotubes",
"as",
"nanofeatured",
"scaffolds",
"for",
"the",
"assisted",
"deposition",
"of",
"nanohydroxyapatite:",
"characterization",
"and",
"biological",
"evaluation",
"Nanohydroxyapatite",
"(nHAp)",
"is",
"an",
"emergent",
"bioceramic",
"that",
"shows",
"similar",
"chemical",
"and",
"crystallographic",
"properties",
"as",
"the",
"mineral",
"phase",
"present",
"in",
"bone.",
"However,",
"nHAp",
"presents",
"low",
"fracture",
"toughness",
"and",
"tensile",
"strength,",
"limiting",
"its",
"application",
"in",
"bone",
"tissue",
"engineering.",
"Conversely,",
"multi-walled",
"carbon",
"nanotubes",
"(MWCNTs)",
"have",
"been",
"widely",
"used",
"for",
"composite",
"applications",
"due",
"to",
"their",
"excellent",
"mechanical",
"and",
"physicochemical",
"properties,",
"although",
"their",
"hydrophobicity",
"usually",
"impairs",
"some",
"applications.",
"To",
"improve",
"MWCNT",
"wettability,",
"oxygen",
"plasma",
"etching",
"has",
"been",
"applied",
"to",
"promote",
"MWCNT",
"exfoliation",
"and",
"oxidation",
"and",
"to",
"produce",
"graphene",
"oxide",
"(GO)",
"at",
"the",
"end",
"of",
"the",
"tips.",
"Here,",
"we",
"prepared",
"a",
"series",
"of",
"nHAp",
"/",
"MWCNT",
"-",
"GO",
"nanocomposites",
"aimed",
"at",
"producing",
"materials",
"that",
"combine",
"similar",
"bone",
"characteristics",
"(nHAp)",
"with",
"high",
"mechanical",
"strength",
"(MWCNT",
"-",
"GO).",
"After",
"MWCNT",
"production",
"and",
"functionalization",
"to",
"produce",
"MWCNT",
"-",
"GO,",
"ultrasonic",
"irradiation",
"was",
"employed",
"to",
"precipitate",
"nHAp",
"onto",
"the",
"MWCNT",
"-",
"GO",
"scaffolds",
"(at",
"1-3",
"wt%).",
"We",
"employed",
"various",
"techniques",
"to",
"characterize",
"the",
"nanocomposites,",
"including",
"transmission",
"electron",
"microscopy",
"(TEM),",
"Raman",
"spectroscopy,",
"thermogravimetry,",
"and",
"gas",
"adsorption",
"(the",
"Brunauer-Emmett-Teller",
"method).",
"We",
"used",
"simulated",
"body",
"fluid",
"to",
"evaluate",
"their",
"bioactivity",
"and",
"human",
"osteoblasts",
"(bone-forming",
"cells)",
"to",
"evaluate",
"cytocompatibility.",
"We",
"also",
"investigated",
"their",
"bactericidal",
"effect",
"against",
"Staphylococcus",
"aureus",
"and",
"Escherichia",
"coli.",
"TEM",
"analysis",
"revealed",
"homogeneous",
"distributions",
"of",
"nHAp",
"crystal",
"grains",
"along",
"the",
"MWCNT",
"-",
"GO",
"surfaces.",
"All",
"nanocomposites",
"were",
"proved",
"to",
"be",
"bioactive,",
"since",
"carbonated",
"nHAp",
"was",
"found",
"after",
"21",
"days",
"in",
"simulated",
"body",
"fluid.",
"All",
"nanocomposites",
"showed",
"potential",
"for",
"biomedical",
"applications",
"with",
"no",
"cytotoxicity",
"toward",
"osteoblasts",
"and",
"impressively",
"demonstrated",
"a",
"bactericidal",
"effect",
"without",
"the",
"use",
"of",
"antibiotics.",
"All",
"of",
"the",
"aforementioned",
"properties",
"make",
"these",
"materials",
"very",
"attractive",
"for",
"bone",
"tissue",
"engineering",
"applications,",
"either",
"as",
"a",
"matrix",
"or",
"as",
"a",
"reinforcement",
"material",
"for",
"numerous",
"polymeric",
"nanocomposites."
] | [
1,
2,
0,
1,
2,
2,
0,
1,
2,
0,
0,
1,
1,
0,
1,
1,
0,
1,
1,
1,
1,
0,
0,
1,
1,
0,
0,
0,
1,
0,
1,
2,
0,
0,
1,
1,
1,
0,
1,
0,
1,
1,
0,
1,
1,
0,
1,
2,
1,
0,
1,
0,
1,
2,
1,
0,
1,
2,
2,
1,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
1,
1,
0,
1,
1,
0,
0,
1,
0,
1,
0,
1,
0,
0,
1,
1,
1,
2,
2,
0,
0,
1,
0,
1,
1,
1,
0,
1,
0,
0,
0,
1,
2,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
1,
1,
1,
0,
0,
1,
0,
0,
0,
1,
1,
1,
0,
0,
1,
2,
1,
0,
1,
0,
1,
1,
0,
1,
0,
0,
1,
0,
1,
1,
1,
0,
1,
0,
1,
1,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
1,
0,
1,
0,
1,
0,
1,
0,
1,
2,
2,
1,
1,
2,
1,
0,
1,
2,
0,
1,
2,
0,
0,
1,
1,
2,
0,
1,
0,
1,
0,
1,
1,
1,
2,
0,
1,
1,
0,
0,
1,
0,
1,
1,
0,
1,
2,
0,
1,
2,
1,
1,
0,
1,
1,
0,
1,
2,
2,
0,
0,
1,
0,
1,
1,
0,
1,
0,
0,
0,
0,
1,
0,
1,
2,
0,
1,
0,
0,
1,
0,
1,
1,
2,
0,
1,
0,
1,
0,
1,
1,
0,
0,
1,
0,
1,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
0,
1,
2,
2,
2,
0,
0,
0,
1,
0,
0,
0,
1,
2,
0,
1,
1,
1
] |
[
"Diagnostic",
"value",
"of",
"diffusion",
"weighted",
"MRI",
"and",
"ADC",
"in",
"differential",
"diagnosis",
"of",
"cavernous",
"hemangioma",
"of",
"the",
"liver",
"To",
"investigate",
"the",
"use",
"of",
"diffusion",
"weighted",
"magnetic",
"resonance",
"imaging",
"(DWI)",
"and",
"the",
"apparent",
"diffusion",
"coefficient",
"(ADC)",
"values",
"in",
"the",
"diagnosis",
"of",
"hemangioma.",
"The",
"study",
"population",
"consisted",
"of",
"72",
"patients",
"with",
"liver",
"masses",
"larger",
"than",
"1",
"cm",
"(72",
"focal",
"lesions).",
"DWI",
"examination",
"with",
"a",
"b",
"value",
"of",
"600",
"s/mm2",
"was",
"carried",
"out",
"for",
"all",
"patients.",
"After",
"DWI",
"examination,",
"an",
"ADC",
"map",
"was",
"created",
"and",
"ADC",
"values",
"were",
"measured",
"for",
"72",
"liver",
"masses",
"and",
"normal",
"liver",
"tissue",
"(control",
"group).",
"The",
"average",
"ADC",
"values",
"of",
"normal",
"liver",
"tissue",
"and",
"focal",
"liver",
"lesions,",
"the",
"\"",
"cut-off",
"\"",
"ADC",
"values,",
"and",
"the",
"diagnostic",
"sensitivity",
"and",
"specificity",
"of",
"the",
"ADC",
"map",
"in",
"diagnosing",
"hemangioma,",
"benign",
"and",
"malignant",
"lesions",
"were",
"researched.",
"Of",
"the",
"72",
"liver",
"masses,",
"51",
"were",
"benign",
"and",
"21",
"were",
"malignant.",
"Benign",
"lesions",
"comprised",
"38",
"hemangiomas",
"and",
"13",
"simple",
"cysts.",
"Malignant",
"lesions",
"comprised",
"9",
"hepatocellular",
"carcinomas,",
"and",
"12",
"metastases.",
"The",
"highest",
"ADC",
"values",
"were",
"measured",
"for",
"cysts",
"(3.782±0.53×10(-3)",
"mm(2)/s)",
"and",
"hemangiomas",
"(2.705±0.63×10(-3)",
"mm(2)/s).",
"The",
"average",
"ADC",
"value",
"of",
"hemangiomas",
"was",
"significantly",
"higher",
"than",
"malignant",
"lesions",
"and",
"the",
"normal",
"control",
"group",
"(p<0.001).",
"The",
"average",
"ADC",
"value",
"of",
"cysts",
"were",
"significantly",
"higher",
"when",
"compared",
"to",
"hemangiomas",
"and",
"normal",
"control",
"group",
"(p<0.001).",
"To",
"distinguish",
"hemangiomas",
"from",
"malignant",
"liver",
"lesions,",
"the",
"\"",
"cut-off",
"\"",
"ADC",
"value",
"of",
"1.800×10(-3)",
"mm(2)/s",
"had",
"a",
"sensitivity",
"of",
"97.4%",
"and",
"a",
"specificity",
"of",
"90.9%.",
"To",
"distinguish",
"hemangioma",
"from",
"normal",
"liver",
"parenchyma",
"the",
"\"",
"cut-off\"",
"value",
"of",
"1.858×10(-3)",
"mm(2)/s",
"had",
"a",
"sensitivity",
"of",
"97.4%",
"and",
"a",
"specificity",
"of",
"95.7%.",
"To",
"distinguish",
"benign",
"liver",
"lesions",
"from",
"malignant",
"liver",
"lesions",
"the",
"\"",
"cut-off\"",
"value",
"of",
"1.800×10(-3)",
"mm(2)/s",
"had",
"a",
"sensitivity",
"of",
"96.1%",
"and",
"a",
"specificity",
"of",
"90.0%.",
"DWI",
"and",
"quantitative",
"measurement",
"of",
"ADC",
"values",
"can",
"be",
"used",
"in",
"differential",
"diagnosis",
"of",
"benign",
"and",
"malignant",
"liver",
"lesions",
"and",
"also",
"in",
"the",
"diagnosis",
"and",
"differentiation",
"of",
"hemangiomas.",
"When",
"dynamic",
"examination",
"cannot",
"distinguish",
"cases",
"with",
"vascular",
"metastasis",
"and",
"lesions",
"from",
"hemangioma,",
"DWI",
"and",
"ADC",
"values",
"can",
"be",
"useful",
"in",
"the",
"primary",
"diagnosis",
"and",
"differential",
"diagnosis.",
"The",
"technique",
"does",
"not",
"require",
"contrast",
"material,",
"so",
"it",
"can",
"safely",
"be",
"used",
"in",
"patients",
"with",
"renal",
"failure."
] | [
1,
2,
0,
1,
2,
2,
0,
1,
0,
1,
2,
0,
1,
2,
0,
0,
1,
0,
1,
0,
1,
2,
1,
2,
2,
2,
2,
1,
0,
0,
1,
2,
2,
1,
1,
0,
0,
1,
0,
1,
0,
1,
2,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
1,
2,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
1,
0,
1,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
1,
2,
0,
1,
1,
2,
1,
2,
0,
1,
1,
1,
0,
1,
1,
2,
0,
1,
2,
2,
0,
0,
1,
0,
1,
1,
0,
0,
1,
2,
0,
1,
0,
0,
1,
0,
0,
1,
1,
1,
0,
1,
1,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
0,
0,
1,
1,
1,
0,
0,
1,
0,
0,
1,
2,
1,
1,
0,
0,
1,
2,
0,
0,
1,
0,
0,
1,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
1,
1,
1,
0,
1,
0,
1,
2,
0,
1,
1,
0,
0,
1,
2,
2,
0,
0,
1,
1,
1,
0,
1,
0,
1,
2,
0,
0,
0,
1,
0,
1,
2,
2,
0,
0,
0,
1,
0,
1,
1,
2,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
1,
1,
2,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
1,
2,
0,
1,
1,
2,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
2,
0,
1,
1,
0,
0,
0,
0,
1,
2,
0,
1,
0,
1,
1,
2,
0,
0,
0,
0,
1,
0,
1,
0,
1,
0,
1,
2,
0,
0,
1,
0,
1,
2,
0,
1,
0,
1,
1,
0,
1,
1,
0,
0,
0,
0,
0,
1,
2,
0,
1,
2,
0,
1,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2
] |
[
"Functional",
"Analysis",
"of",
"a",
"Bacterial",
"Antifreeze",
"Protein",
"Indicates",
"a",
"Cooperative",
"Effect",
"between",
"Its",
"Two",
"Ice-Binding",
"Domains",
"Antifreeze",
"proteins",
"make",
"up",
"a",
"class",
"of",
"ice-binding",
"proteins",
"(IBPs)",
"that",
"are",
"possessed",
"and",
"expressed",
"by",
"certain",
"cold",
"-",
"adapted",
"organisms",
"to",
"enhance",
"their",
"freezing",
"tolerance.",
"Here",
"we",
"report",
"the",
"biophysical",
"and",
"functional",
"characterization",
"of",
"an",
"IBP",
"discovered",
"in",
"a",
"bacterium",
"recovered",
"from",
"a",
"deep",
"glacial",
"ice",
"core",
"drilled",
"at",
"Vostok",
"Station,",
"Antarctica",
"(IBPv).",
"Our",
"study",
"showed",
"that",
"the",
"recombinant",
"protein",
"rIBPv",
"exhibited",
"a",
"thermal",
"hysteresis",
"of",
"2",
"°C",
"at",
"concentrations",
"of",
">50",
"μM,",
"effectively",
"inhibited",
"ice",
"recrystallization,",
"and",
"enhanced",
"bacterial",
"viability",
"during",
"freeze-thaw",
"cycling.",
"Circular",
"dichroism",
"scans",
"indicated",
"that",
"rIBPv",
"mainly",
"consists",
"of",
"β",
"strands,",
"and",
"its",
"denaturing",
"temperature",
"was",
"53.5",
"°C.",
"Multiple-sequence",
"alignment",
"of",
"homologous",
"IBPs",
"predicted",
"that",
"IBPv",
"contains",
"two",
"ice-binding",
"domains,",
"a",
"feature",
"unique",
"among",
"known",
"IBPs.",
"To",
"examine",
"functional",
"differences",
"between",
"the",
"IBPv",
"domains,",
"each",
"domain",
"was",
"cloned,",
"expressed,",
"and",
"purified.",
"The",
"second",
"domain",
"(domain",
"B)",
"expressed",
"greater",
"ice",
"binding",
"activity.",
"Data",
"from",
"thermal",
"hysteresis",
"and",
"gel",
"filtration",
"assays",
"supported",
"the",
"idea",
"that",
"the",
"two",
"domains",
"cooperate",
"to",
"achieve",
"a",
"higher",
"ice",
"binding",
"effect",
"by",
"forming",
"heterodimers.",
"However,",
"physical",
"linkage",
"of",
"the",
"domains",
"was",
"not",
"required",
"for",
"this",
"effect."
] | [
1,
1,
0,
0,
1,
1,
2,
0,
0,
1,
1,
0,
0,
0,
1,
1,
1,
2,
0,
0,
0,
0,
0,
1,
2,
1,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
1,
0,
1,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
1,
1,
1,
2,
0,
0,
1,
2,
2,
1,
0,
1,
0,
0,
0,
1,
2,
1,
0,
0,
1,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
1,
1,
0,
1,
1,
2,
0,
1,
2,
1,
2,
2,
0,
0,
1,
0,
0,
0,
1,
2,
0,
0,
1,
1,
0,
0,
0,
1,
2,
0,
1,
2,
0,
0,
1,
0,
0,
1,
2,
0,
0,
1,
0,
0,
1,
0,
0,
1,
0,
0,
0,
1,
2,
0,
1,
0,
1,
1,
0,
1,
0,
1,
1,
0,
2,
1,
0,
1,
2,
2,
0,
0,
1,
1,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0
] |
[
"Structural",
"Remodeling",
"of",
"Sympathetic",
"Innervation",
"in",
"Atherosclerotic",
"Blood",
"Vessels:",
"Role",
"of",
"Atherosclerotic",
"Disease",
"Progression",
"and",
"Chronic",
"Social",
"Stress",
"The",
"sympathetic",
"nervous",
"system",
"(SNS)",
"can",
"undergo",
"dramatic",
"structural",
"plasticity",
"in",
"response",
"to",
"behavioral",
"factors",
"and/or",
"the",
"presence",
"of",
"disease,",
"leading",
"to",
"SNS",
"hyperinnervation",
"of",
"peripheral",
"tissues.",
"The",
"SNS",
"has",
"been",
"proposed",
"as",
"an",
"important",
"mediator",
"between",
"stressful",
"behavior",
"and",
"the",
"progression",
"of",
"atherosclerosis",
"in",
"the",
"vasculature.",
"The",
"present",
"study",
"examined",
"whether",
"structural",
"remodeling",
"of",
"the",
"SNS",
"occurs",
"in",
"the",
"vasculature",
"in",
"a",
"genetically",
"hyperlipidemic",
"animal",
"model",
"of",
"atherosclerosis,",
"the",
"Watanabe",
"heritable",
"hyperlipidemic",
"rabbit",
"(WHHL;",
"relative",
"to",
"normolipidemic",
"New",
"Zealand",
"white",
"rabbits",
"[NZW]),",
"and",
"whether",
"SNS",
"plasticity",
"is",
"driven",
"by",
"the",
"progression",
"of",
"disease",
"and/or",
"by",
"stressful",
"social",
"behavior.",
"WHHL",
"and",
"NZW",
"rabbits",
"were",
"assigned",
"to",
"an",
"unstable",
"or",
"stable",
"social",
"environment",
"for",
"4",
"months.",
"Aortic",
"atherosclerosis",
"was",
"assessed",
"and",
"SNS",
"aortic",
"innervation",
"quantified",
"using",
"immunofluorescent",
"microscopy.",
"Numerous",
"SNS",
"varicosities",
"were",
"observed",
"throughout",
"the",
"aorta",
"in",
"WHHLs",
"and",
"NZWs,",
"extending",
"into",
"the",
"vascular",
"media",
"and",
"intima,",
"an",
"innervation",
"pattern",
"not",
"previously",
"reported.",
"WHHLs",
"exhibited",
"significantly",
"greater",
"innervation",
"than",
"NZWs",
"(F(1,41)",
"=",
"55.3,",
"p",
"<",
".001),",
"with",
"extensive",
"innervation",
"of",
"the",
"atherosclerotic",
"neointima.",
"The",
"innervation",
"density",
"was",
"highly",
"correlated",
"with",
"the",
"extent",
"of",
"disease",
"in",
"the",
"WHHLs",
"(r(21)",
"=",
"0.855,",
"p",
"<",
".001).",
"Social",
"environment",
"did",
"not",
"influence",
"innervation",
"in",
"NZWs",
"(aortic",
"arch:",
"p",
"=",
".078,",
"thoracic",
"aorta:",
"p",
"=",
".34)",
"or",
"WHHLs",
"(arch:",
"p",
"=",
".97,",
"thoracic:",
"p",
"=",
".61).",
"The",
"findings",
"suggest",
"that",
"hyperinnervation",
"is",
"driven",
"largely",
"by",
"the",
"progression",
"of",
"disease",
"rather",
"than",
"social",
"environment.",
"SNS",
"innervation",
"patterns",
"observed",
"in",
"atherosclerotic",
"human",
"and",
"mouse",
"aortas",
"were",
"consistent",
"with",
"the",
"rabbit,",
"suggesting",
"that",
"SNS",
"hyperinnervation",
"of",
"the",
"diseased",
"vessel",
"wall",
"is",
"a",
"general",
"feature",
"across",
"mammalian",
"species."
] | [
1,
2,
0,
1,
2,
0,
1,
1,
2,
0,
0,
1,
1,
2,
0,
1,
1,
2,
0,
1,
2,
2,
1,
0,
0,
1,
2,
2,
0,
0,
0,
1,
1,
0,
0,
1,
0,
1,
0,
0,
1,
1,
0,
1,
2,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
1,
0,
1,
0,
0,
1,
0,
0,
1,
0,
0,
1,
2,
0,
0,
1,
0,
0,
0,
1,
0,
0,
1,
1,
1,
2,
0,
1,
0,
1,
2,
2,
2,
1,
0,
0,
1,
1,
2,
2,
2,
1,
0,
0,
1,
1,
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
1,
2,
1,
0,
1,
1,
0,
0,
0,
0,
1,
0,
1,
1,
2,
0,
0,
1,
1,
2,
0,
0,
0,
1,
1,
1,
0,
0,
1,
2,
0,
1,
1,
0,
0,
0,
0,
1,
0,
1,
0,
1,
0,
0,
0,
1,
2,
0,
1,
0,
1,
0,
0,
0,
0,
1,
0,
1,
2,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
1,
0,
1,
1,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
0,
1,
1,
2,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
1,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
2,
1,
1,
1,
0,
0,
1,
1,
0,
1,
1,
0,
0,
0,
0,
1,
0,
0,
1,
1,
0,
0,
1,
1,
2,
0,
0,
0,
0,
0,
1,
2
] |
[
"\"You",
"get",
"to",
"know",
"the",
"people",
"and",
"whether",
"they're",
"talking",
"sense",
"or",
"not\":",
"Negotiating",
"trust",
"on",
"health",
"-related",
"forums",
"The",
"internet",
"is",
"increasingly",
"being",
"used",
"as",
"a",
"source",
"of",
"health",
"advice",
"and",
"information",
"by",
"individuals",
"with",
"long",
"term",
"conditions",
"(LTCs).",
"Specifically,",
"online",
"forums",
"allow",
"people",
"to",
"interact",
"with",
"others",
"with",
"similar",
"conditions.",
"However,",
"it",
"is",
"not",
"clear",
"how",
"online",
"health",
"information",
"is",
"assessed",
"by",
"those",
"with",
"LTCs.",
"This",
"study",
"aims",
"to",
"address",
"this",
"gap",
"by",
"exploring",
"how",
"individuals",
"with",
"contested",
"and",
"uncontested",
"LTCs",
"utilise",
"internet",
"forums.",
"Semi-structured",
"interviews",
"were",
"conducted",
"with",
"20",
"participants",
"with",
"ME",
"/",
"CFS",
"and",
"21",
"participants",
"with",
"type",
"1",
"and",
"2",
"diabetes",
"and",
"analysed",
"using",
"thematic",
"analysis.",
"Participants",
"were",
"recruited",
"via",
"online",
"and",
"offline",
"routes,",
"namely",
"forums,",
"email",
"lists,",
"newsletters,",
"and",
"face-to-face",
"support",
"groups.",
"The",
"findings",
"indicate",
"that",
"the",
"use",
"of",
"online",
"forums",
"was",
"a",
"complex",
"and",
"nuanced",
"process",
"and",
"was",
"influenced",
"by",
"a",
"number",
"of",
"individual",
"and",
"illness",
"-",
"specific",
"factors.",
"Participants",
"trusted",
"those",
"with",
"similar",
"experiences",
"and",
"perspectives",
"as",
"themselves,",
"while",
"also",
"valuing",
"conventional",
"biomedical",
"information",
"and",
"advice.",
"By",
"accessing",
"support",
"online",
"forum",
"users",
"were",
"able",
"to",
"draw",
"on",
"a",
"personalised",
"form",
"of",
"support",
"based",
"on",
"the",
"lived",
"experiences",
"of",
"their",
"peers.",
"However,",
"the",
"role",
"of",
"digital",
"literacy",
"in",
"developing",
"and",
"maintaining",
"online",
"relationships",
"must",
"be",
"acknowledged."
] | [
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
1,
1,
0,
1,
0,
1,
0,
1,
0,
1,
0,
0,
0,
0,
1,
0,
1,
2,
0,
1,
0,
1,
0,
1,
2,
1,
1,
0,
1,
2,
0,
1,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
1,
1,
2,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
1,
2,
1,
2,
0,
0,
0,
0,
1,
0,
1,
0,
1,
0,
0,
1,
0,
1,
2,
0,
1,
2,
0,
1,
0,
1,
2,
1,
0,
0,
0,
1,
0,
1,
2,
0,
1,
1,
2,
1,
0,
1,
1,
2,
0,
1,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
0,
1,
0,
0,
1,
0,
0,
0,
0,
1,
0,
1,
0,
1,
1,
1,
1,
0,
0,
1,
1,
0,
1,
0,
0,
0,
0,
0,
1,
1,
1,
0,
1,
0,
1,
0,
1,
2,
1,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
1,
1,
0,
0,
1
] |
[
"Colony",
"Expansion",
"of",
"Socially",
"Motile",
"Myxococcus",
"xanthus",
"Cells",
"Is",
"Driven",
"by",
"Growth,",
"Motility,",
"and",
"Exopolysaccharide",
"Production",
"Myxococcus",
"xanthus,",
"a",
"model",
"organism",
"for",
"studies",
"of",
"multicellular",
"behavior",
"in",
"bacteria,",
"moves",
"exclusively",
"on",
"solid",
"surfaces",
"using",
"two",
"distinct",
"but",
"coordinated",
"motility",
"mechanisms.",
"One",
"of",
"these,",
"social",
"(S)",
"motility",
"is",
"powered",
"by",
"the",
"extension",
"and",
"retraction",
"of",
"type",
"IV",
"pili",
"and",
"requires",
"the",
"presence",
"of",
"exopolysaccharides",
"(EPS)",
"produced",
"by",
"neighboring",
"cells.",
"As",
"a",
"result,",
"S",
"motility",
"requires",
"close",
"cell-to-cell",
"proximity",
"and",
"isolated",
"cells",
"do",
"not",
"translocate.",
"Previous",
"studies",
"measuring",
"S",
"motility",
"by",
"observing",
"the",
"colony",
"expansion",
"of",
"cells",
"deposited",
"on",
"agar",
"have",
"shown",
"that",
"the",
"expansion",
"rate",
"increases",
"with",
"initial",
"cell",
"density,",
"but",
"the",
"biophysical",
"mechanisms",
"involved",
"remain",
"largely",
"unknown.",
"To",
"understand",
"the",
"dynamics",
"of",
"S",
"motility",
"-driven",
"colony",
"expansion,",
"we",
"developed",
"a",
"reaction",
"-",
"diffusion",
"model",
"describing",
"the",
"effects",
"of",
"cell",
"density,",
"EPS",
"deposition",
"and",
"nutrient",
"exposure",
"on",
"the",
"expansion",
"rate.",
"Our",
"results",
"show",
"that",
"at",
"steady",
"state",
"the",
"population",
"expands",
"as",
"a",
"traveling",
"wave",
"with",
"a",
"speed",
"determined",
"by",
"the",
"interplay",
"of",
"cell",
"motility",
"and",
"growth,",
"a",
"well-known",
"characteristic",
"of",
"Fisher's",
"equation.",
"The",
"model",
"explains",
"the",
"density",
"-",
"dependence",
"of",
"the",
"colony",
"expansion",
"by",
"demonstrating",
"the",
"presence",
"of",
"a",
"lag",
"phase",
"-a",
"transient",
"period",
"of",
"very",
"slow",
"expansion",
"with",
"a",
"duration",
"dependent",
"on",
"the",
"initial",
"cell",
"density.",
"We",
"propose",
"that",
"at",
"a",
"low",
"initial",
"density,",
"more",
"time",
"is",
"required",
"for",
"the",
"cells",
"to",
"accumulate",
"enough",
"EPS",
"to",
"activate",
"S-motility",
"resulting",
"in",
"a",
"longer",
"lag",
"period.",
"Furthermore,",
"our",
"model",
"makes",
"the",
"novel",
"prediction",
"that",
"following",
"the",
"lag",
"phase",
"the",
"population",
"expands",
"at",
"a",
"constant",
"rate",
"independent",
"of",
"the",
"cell",
"density.",
"These",
"predictions",
"were",
"confirmed",
"by",
"S",
"motility",
"experiments",
"capturing",
"long-term",
"expansion",
"dynamics."
] | [
1,
1,
0,
1,
2,
1,
2,
1,
0,
0,
0,
1,
1,
0,
1,
1,
1,
2,
0,
1,
1,
0,
1,
0,
1,
2,
0,
1,
0,
0,
0,
1,
1,
0,
0,
0,
0,
1,
1,
1,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
1,
0,
1,
0,
1,
2,
2,
0,
0,
0,
0,
0,
1,
1,
0,
0,
1,
1,
0,
0,
0,
1,
2,
0,
0,
1,
1,
0,
1,
1,
0,
0,
1,
1,
2,
1,
1,
2,
0,
1,
0,
1,
1,
0,
1,
1,
0,
1,
0,
0,
0,
0,
1,
1,
1,
0,
1,
1,
2,
0,
0,
1,
1,
1,
0,
0,
1,
1,
2,
0,
1,
0,
1,
2,
0,
1,
1,
0,
0,
0,
1,
0,
1,
1,
1,
0,
1,
2,
1,
2,
1,
1,
0,
1,
1,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
2,
0,
1,
1,
0,
0,
0,
0,
0,
0,
1,
1,
2,
0,
0,
0,
1,
2,
0,
1,
0,
0,
1,
0,
1,
2,
0,
1,
0,
0,
1,
0,
1,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
1,
0,
1,
2,
1,
0,
0,
1,
1,
0,
0,
1,
1,
2,
0,
0,
0,
0,
0,
1,
1,
1,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
1,
0,
1,
1,
2,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
1,
1,
0,
1,
0,
0,
1,
0,
1,
1,
0,
0,
1,
1,
1,
2,
0,
1,
2,
0,
1,
0,
1,
2,
1,
2,
1,
0,
1,
1,
1
] |
[
"Ultrasound",
"assessment",
"of",
"lung",
"consolidation",
"and",
"reaeration",
"after",
"pleural",
"effusion",
"drainage",
"in",
"patients",
"with",
"Acute",
"Respiratory",
"Distress",
"Syndrome:",
"a",
"pilot",
"study",
"The",
"aim",
"of",
"the",
"pilot",
"study",
"was",
"to",
"assess",
"by",
"ultrasound",
"changes",
"in",
"dimensions",
"of",
"lung",
"consolidation",
"and",
"reaeration",
"after",
"drainage",
"of",
"large",
"pleural",
"effusion",
"in",
"patients",
"with",
"acute",
"respiratory",
"distress",
"syndrome",
"(ARDS).",
"Lung",
"ultrasound",
"and",
"blood",
"gas",
"were",
"performed",
"before,",
"2",
"hours",
"(H2)",
"and",
"24",
"hours",
"(H24)",
"after",
"drainage",
"of",
"pleural",
"effusion.",
"Lung",
"ultrasound",
"aeration",
"score",
"was",
"calculated.",
"Cephalocaudal",
"dimension",
"and",
"diaphragmatic",
"transversal",
"area",
"of",
"lung",
"consolidation",
"were",
"measured.",
"Ten",
"patients",
"were",
"studied.",
"Median",
"volume",
"of",
"drained",
"effusion",
"was",
"675",
"ml",
"at",
"H2",
"and",
"895",
"at",
"H24.",
"Two",
"hours",
"after",
"drainage,",
"dimension",
"of",
"cephalocaudal",
"consolidation",
"and",
"diaphragmatic",
"transversal",
"area",
"decreased",
"significantly.",
"Lung",
"reaeration",
"after",
"drainage",
"occurred",
"mainly",
"in",
"latero-inferior",
"and",
"postero-superior",
"regions.",
"PaO2/FiO2",
"increased",
"significantly",
"at",
"H24.",
"Ultrasound",
"is",
"a",
"useful",
"method",
"to",
"assess",
"lung",
"consolidation",
"after",
"pleural",
"effusion",
"drainage.",
"Drainage",
"of",
"pleural",
"effusion",
"may",
"lead",
"to",
"a",
"decrease",
"of",
"lung",
"consolidation",
"and",
"improvement",
"of",
"lung",
"reaeration."
] | [
1,
1,
0,
1,
2,
0,
1,
0,
1,
2,
1,
0,
1,
0,
1,
2,
2,
2,
0,
1,
2,
0,
1,
0,
0,
1,
2,
0,
0,
1,
0,
1,
0,
0,
1,
0,
1,
2,
0,
1,
0,
1,
0,
0,
1,
2,
0,
1,
0,
1,
2,
2,
2,
1,
1,
2,
0,
1,
2,
0,
1,
0,
1,
2,
1,
0,
1,
2,
1,
0,
1,
0,
1,
2,
1,
2,
2,
2,
0,
0,
1,
2,
0,
1,
2,
2,
0,
1,
2,
0,
0,
0,
1,
0,
0,
1,
2,
0,
1,
1,
0,
0,
0,
0,
1,
0,
0,
0,
1,
1,
2,
0,
1,
1,
2,
2,
2,
0,
1,
2,
2,
0,
0,
1,
2,
0,
1,
0,
0,
0,
1,
0,
1,
2,
1,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
1,
2,
0,
1,
2,
1,
1,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
2,
0,
1,
0,
1,
2
] |
[
"Naphthoquinone",
"glycosides",
"for",
"bioelectroanalytical",
"enumeration",
"of",
"the",
"faecal",
"indicator",
"Escherichia",
"coli",
"Microbial",
"water",
"quality",
"monitoring",
"for",
"the",
"presence",
"of",
"faecal",
"indicator",
"bacteria",
"(FIB)",
"is",
"a",
"mandatory",
"activity",
"in",
"many",
"countries",
"and",
"is",
"key",
"in",
"public",
"health",
"protection.",
"Despite",
"technological",
"advances",
"and",
"a",
"need",
"for",
"methodological",
"improvements,",
"chromogenic",
"and",
"fluorogenic",
"enzymatic",
"techniques",
"remain",
"the",
"mainstays",
"of",
"water",
"quality",
"monitoring",
"for",
"both",
"public",
"health",
"agencies",
"and",
"regulated",
"utilities.",
"We",
"demonstrated",
"that",
"bioelectroanalytical",
"approaches",
"to",
"FIB",
"enumeration",
"are",
"possible",
"and",
"can",
"be",
"achieved",
"using",
"commercially",
"available",
"enzyme",
"-",
"specific",
"resorufin",
"glycosides,",
"although",
"these",
"are",
"expensive,",
"not",
"widely",
"available",
"or",
"designed",
"for",
"purpose.",
"Following",
"this,",
"we",
"designed",
"two",
"naphthoquinone",
"glycosides",
"which",
"performed",
"better,",
"achieving",
"Escherichia",
"coli",
"detection",
"in",
"the",
"range",
"5.0",
"×",
"10(2)",
"to",
"5.0",
"×",
"10(5)",
"CFU",
"ml(-1)",
"22-54%",
"quicker",
"than",
"commercially",
"available",
"resorufin",
"glycosides.",
"The",
"molecular",
"design",
"of",
"the",
"naphthoquinone",
"glycosides",
"requires",
"fewer",
"synthetic",
"steps",
"allowing",
"them",
"to",
"be",
"produced",
"for",
"as",
"little",
"as",
"US$50",
"per",
"kg.",
"Tests",
"with",
"environmental",
"samples",
"demonstrated",
"the",
"low",
"tendency",
"for",
"abiotic",
"interference",
"and",
"that,",
"despite",
"specificity",
"being",
"maintained",
"between",
"β-glucuronidase",
"and",
"β-galactosidase,",
"accurate",
"enumeration",
"of",
"E.",
"coli",
"in",
"environmental",
"samples",
"necessitates",
"development",
"of",
"a",
"selective",
"medium.",
"In",
"comparison",
"to",
"a",
"commercially",
"available",
"detection",
"method,",
"which",
"has",
"U.S.",
"Environmental",
"Protection",
"Agency",
"(EPA)",
"approval,",
"our",
"approach",
"performed",
"better",
"at",
"high",
"organism",
"concentrations,",
"detecting",
"500",
"organisms",
"in",
"9",
"h",
"compared",
"with",
"13.5",
"h",
"for",
"the",
"commercial",
"method.",
"Bioelectroanalytical",
"detection",
"is",
"comparable",
"to",
"current",
"approved",
"methods",
"and",
"with",
"further",
"development",
"could",
"result",
"in",
"improved",
"detection",
"times.",
"A",
"recent",
"trend",
"for",
"low-cost",
"open-source",
"hardware",
"means",
"that",
"automated,",
"potentiostatically",
"controlled",
"E.",
"coli",
"detection",
"systems",
"could",
"be",
"constructed",
"for",
"less",
"than",
"US$100",
"per",
"channel."
] | [
1,
1,
0,
1,
2,
0,
0,
1,
1,
1,
2,
1,
1,
2,
1,
0,
0,
0,
0,
1,
2,
2,
1,
0,
0,
1,
2,
0,
0,
1,
0,
0,
0,
0,
1,
2,
2,
0,
1,
2,
0,
0,
0,
0,
1,
1,
1,
0,
1,
2,
2,
0,
0,
0,
0,
1,
2,
1,
0,
0,
1,
2,
2,
2,
2,
2,
0,
0,
0,
1,
2,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
1,
2,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
1,
0,
1,
2,
0,
0,
1,
1,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
1,
0,
1,
2,
0,
1,
1,
0,
0,
0,
0,
1,
2,
0,
1,
0,
0,
0,
0,
1,
1,
0,
0,
1,
2,
2,
2,
1,
1,
0,
0,
1,
2,
0,
0,
1,
1,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
2,
1,
2,
0,
1,
0,
1,
2,
2,
0,
0,
1,
2,
0,
1,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
1,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
[
"Evaluation",
"of",
"Local",
"CYP17A1",
"and",
"CYP19A1",
"Expression",
"Levels",
"as",
"Prognostic",
"Factors",
"in",
"Postmenopausal",
"Invasive",
"Ductal",
"Breast",
"Cancer",
"Cases",
"There",
"is",
"growing",
"attention",
"focused",
"on",
"local",
"estrogen",
"production",
"in",
"the",
"breast",
"tissue",
"and",
"its",
"possible",
"role",
"in",
"breast",
"cancer",
"initiation",
"and",
"progression.",
"Understanding",
"the",
"underlying",
"mechanisms",
"for",
"estrogen",
"synthesis",
"and",
"the",
"microenvironment",
"consisting",
"of",
"tumor",
"and",
"its",
"surrounding",
"adipose",
"tissue",
"might",
"open",
"new",
"avenues",
"in",
"breast",
"cancer",
"prevention,",
"prognosis",
"and",
"treatment.",
"In",
"order",
"to",
"obtain",
"insight,",
"we",
"compared",
"peritumoral",
"and",
"tumor",
"tissue",
"expressions",
"of",
"CYP17A1",
"and",
"CYP19A1",
"genes,",
"which",
"play",
"an",
"important",
"role",
"in",
"estrogen",
"biosynthesis.",
"The",
"paired",
"tissue",
"samples",
"of",
"20",
"postmenopausal",
"ER(+)",
"/",
"PR(+)",
"patients",
"diagnosed",
"with",
"invasive",
"ductal",
"breast",
"cancer",
"were",
"studied.",
"In",
"addition,",
"12",
"breast",
"tissue",
"samples",
"obtained",
"from",
"premenopausal",
"women",
"without",
"a",
"history",
"of",
"breast",
"cancer",
"were",
"also",
"investigated",
"as",
"representative",
"of",
"normal",
"conditions.",
"Peritumoral",
"adipose",
"tissues",
"expressed",
"CYP19A1",
"approximately",
"threefold",
"higher",
"than",
"tumor",
"itself",
"(p",
"=",
"0.001).",
"A",
"nonsignificant",
"trend",
"toward",
"low",
"expression",
"of",
"CYP17A1",
"was",
"observed",
"in",
"peritumoral",
"compared",
"to",
"tumor",
"tissue",
"(p",
"=",
"0.687).",
"Clinicopathological",
"parameters",
"and",
"patient",
"characteristics",
"which",
"are",
"accepted",
"as",
"risk",
"factors",
"for",
"breast",
"cancer",
"were",
"also",
"associated",
"with",
"individual",
"and",
"combined",
"expressions",
"of",
"CYP17A1",
"and",
"CYP19A1.",
"This",
"study",
"offers",
"that",
"evaluation",
"of",
"CYP17A1",
"and",
"CYP19A1",
"local",
"expression",
"levels",
"might",
"be",
"useful",
"for",
"deciding",
"on",
"personalized",
"treatment",
"approaches",
"and",
"more",
"accurate",
"diagnosis,",
"when",
"evaluated",
"together",
"with",
"several",
"clinicopathological",
"and",
"disease",
"risk",
"factors.",
"Considering",
"the",
"key",
"role",
"of",
"these",
"CYPs",
"in",
"estrogen",
"synthesis,",
"determining",
"their",
"expression",
"levels",
"may",
"be",
"useful",
"as",
"a",
"postdiagnostic",
"marker",
"and",
"for",
"choosing",
"the",
"right",
"treatment",
"method",
"in",
"addition",
"to",
"the",
"conventional",
"approach."
] | [
1,
0,
1,
1,
0,
1,
1,
2,
0,
1,
2,
0,
1,
1,
2,
2,
2,
1,
0,
0,
0,
0,
0,
0,
1,
1,
2,
0,
0,
1,
2,
0,
0,
0,
1,
0,
1,
2,
1,
0,
1,
0,
0,
0,
1,
0,
1,
2,
0,
0,
1,
0,
0,
1,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
2,
2,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
1,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
1,
1,
0,
1,
1,
1,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
1,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
2,
1,
1,
2,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
1,
0,
0,
0,
1,
0,
0,
1,
2,
0,
0,
0,
1,
2,
0,
1,
2,
0,
0,
0,
0,
1,
2,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
1,
0,
0,
0,
0,
1,
0,
1,
0,
1,
1,
1,
2,
0,
0,
0,
0,
0,
0,
1,
1,
2,
0,
1,
2,
1,
0,
1,
0,
0,
0,
1,
0,
1,
2,
2,
0,
0,
1,
2,
0,
0,
1,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
1,
2,
0,
0,
0,
0,
0,
0
] |
[
"A",
"case",
"study",
"of",
"the",
"introduction",
"of",
"the",
"International",
"Classification",
"for",
"Nursing",
"Practice",
"(®)",
"in",
"Poland",
"The",
"development",
"of",
"a",
"nursing",
"practice,",
"improvements",
"in",
"nurses'",
"autonomy,",
"and",
"increased",
"professional",
"and",
"personal",
"responsibility",
"for",
"the",
"medical",
"services",
"provided",
"all",
"require",
"professional",
"documentation",
"with",
"records",
"of",
"health",
"status",
"assessments,",
"decisions",
"undertaken,",
"actions",
"and",
"their",
"outcomes",
"for",
"each",
"patient.",
"The",
"International",
"Classification",
"for",
"Nursing",
"Practice",
"is",
"a",
"tool",
"that",
"meets",
"all",
"of",
"these",
"needs,",
"and",
"although",
"it",
"requires",
"continuous",
"evaluation,",
"it",
"offers",
"professional",
"documentation",
"and",
"communication",
"in",
"the",
"practitioner",
"and",
"researcher",
"community.",
"The",
"aim",
"of",
"this",
"paper",
"is",
"to",
"present",
"a",
"theoretical",
"critique",
"of",
"an",
"issue",
"related",
"to",
"policy",
"and",
"experience",
"of",
"the",
"current",
"situation",
"in",
"Polish",
"nursing",
"-",
"especially",
"of",
"the",
"efforts",
"to",
"standardize",
"nursing",
"practices",
"through",
"the",
"introduction",
"and",
"development",
"of",
"the",
"Classification",
"in",
"Poland.",
"Despite",
"extensive",
"promotion",
"and",
"training",
"by",
"International",
"Council",
"of",
"Nurses",
"members",
"worldwide,",
"there",
"are",
"still",
"many",
"countries",
"where",
"the",
"Classification",
"has",
"not",
"been",
"implemented",
"as",
"a",
"standard",
"tool",
"in",
"healthcare",
"facilities.",
"Recently,",
"a",
"number",
"of",
"initiatives",
"were",
"undertaken",
"in",
"cooperation",
"with",
"the",
"local",
"and",
"state",
"authorities",
"to",
"disseminate",
"the",
"Classification",
"in",
"healthcare",
"facilities.",
"Thanks",
"to",
"intense",
"efforts",
"by",
"the",
"Polish",
"Nurses",
"Association",
"and",
"the",
"International",
"Council",
"of",
"Nurses",
"Accredited",
"Center",
"for",
"ICNP",
"(®)",
"Research",
"&",
"Development",
"at",
"the",
"Medical",
"University",
"of",
"Łódź,",
"the",
"Classification",
"is",
"known",
"in",
"Poland",
"and",
"has",
"been",
"tested",
"at",
"several",
"centres.",
"Nevertheless,",
"an",
"actual",
"implementation",
"that",
"would",
"allow",
"for",
"national",
"and",
"international",
"interoperability",
"requires",
"strategic",
"governmental",
"decisions",
"and",
"close",
"cooperation",
"with",
"information",
"technology",
"companies",
"operating",
"in",
"the",
"country.",
"Discussing",
"the",
"barriers",
"to",
"the",
"implementation",
"of",
"the",
"Classification",
"can",
"improve",
"understanding",
"of",
"it",
"and",
"its",
"use.",
"At",
"a",
"policy",
"level,",
"decision",
"makers",
"need",
"to",
"understand",
"that",
"use",
"Classification",
"in",
"eHealth",
"services",
"and",
"tools",
"it",
"is",
"necessary",
"to",
"achieve",
"interoperability."
] | [
0,
1,
2,
0,
0,
1,
0,
0,
1,
2,
2,
2,
2,
0,
0,
1,
0,
1,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
1,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
1,
2,
0,
1,
2,
2,
2,
1,
1,
2,
1,
0,
0,
1,
0,
0,
1,
0,
1,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
0,
1,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
1,
0,
0,
1,
0,
1,
0,
1,
2,
0,
1,
0,
1,
2,
2,
2,
1,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
2,
0,
1,
0,
1,
0,
1,
2,
0,
0,
0,
1,
0,
0,
1,
2,
2,
0,
0,
1,
2,
2,
2,
0,
0,
0,
1,
0,
1,
2,
2,
0,
0,
1,
2,
2,
2,
0,
1,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
1,
0,
1,
2,
2,
0,
0,
1,
0,
1,
2,
1,
0,
0,
0,
1,
0,
0,
1,
0,
0,
1,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
1
] |
[
"A",
"Cyclin",
"D2",
"-derived",
"peptide",
"acts",
"on",
"specific",
"cell",
"cycle",
"phases",
"by",
"activating",
"ERK1/2",
"to",
"cause",
"the",
"death",
"of",
"breast",
"cancer",
"cells",
"Protein",
"degradation",
"by",
"the",
"proteasome",
"generates",
"functional",
"intracellular",
"peptides.",
"Pep5,",
"a",
"peptide",
"derived",
"from",
"Cyclin",
"D2,",
"induces",
"cell",
"death",
"in",
"tumor",
"cell",
"lines",
"and",
"reduces",
"the",
"volume",
"of",
"rat",
"C6",
"glioblastoma",
"tumors",
"in",
"vivo.",
"Here,",
"we",
"chose",
"the",
"human",
"MDA-MB-231",
"breast",
"cancer",
"cells",
"to",
"evaluate",
"the",
"mechanism",
"of",
"cell",
"death",
"induced",
"by",
"pep5",
"in",
"different",
"phases",
"of",
"the",
"cell",
"cycle.",
"Fluorescently",
"labeled",
"pep5,",
"monitored",
"by",
"real",
"time",
"confocal",
"microscopy,",
"entered",
"the",
"MDA-MB-231",
"cells",
"3min",
"after",
"application",
"and",
"localized",
"to",
"the",
"nucleus",
"and",
"cytoplasm.",
"Pep5",
"-",
"induced",
"cell",
"death",
"was",
"increased",
"when",
"the",
"MDA-MB-231",
"cell",
"population",
"was",
"arrested",
"at",
"the",
"G1/S",
"transition",
"or",
"in",
"S",
"phase",
"compared",
"to",
"asynchronous",
"cells.",
"Pep5",
"induced",
"permanent",
"extracellular",
"signal-regulated",
"kinase",
"(ERK1/2)",
"phosphorylation",
"in",
"MDA-MB-231",
"cells",
"synchronized",
"in",
"G1/S",
"or",
"S",
"phase.",
"Affinity",
"chromatography",
"followed",
"by",
"mass",
"spectrometry",
"identified",
"CLIC1",
"and",
"Plectin",
"as",
"the",
"only",
"two",
"proteins",
"that",
"interacted",
"with",
"pep5",
"in",
"both",
"asynchronous",
"and",
"synchronized",
"MDA-MB-231",
"cells.",
"These",
"interactions",
"could",
"explain",
"the",
"long-lasting",
"ERK1/2",
"phosphorylation",
"and",
"the",
"cytoskeleton",
"perturbations",
"in",
"the",
"MDA-MB-231",
"cells,",
"in",
"which",
"the",
"stress",
"fibers",
"'",
"integrity",
"is",
"affected",
"by",
"pep5",
"treatments.",
"These",
"data",
"suggest",
"that",
"pep5",
"has",
"potential",
"therapeutic",
"properties",
"for",
"treating",
"specific",
"types",
"of",
"cancers,",
"such",
"as",
"breast",
"cancer",
"cells.",
"Pep5,",
"a",
"natural",
"intracellular",
"peptide",
"formed",
"by",
"the",
"degradation",
"of",
"Cyclin",
"D2",
"through",
"the",
"ubiquitin-proteasome",
"system,",
"induces",
"cell",
"death",
"when",
"reintroduced",
"into",
"MDA-MB-231",
"breast",
"cancer",
"cells,",
"which",
"express",
"low",
"levels",
"of",
"Cyclin",
"D2,",
"specifically",
"in",
"G1/S",
"arrested",
"cells",
"or",
"in",
"cells",
"that",
"are",
"passing",
"through",
"S",
"phase.",
"Under",
"these",
"conditions,",
"pep5",
"is",
"able",
"to",
"interact",
"with",
"different",
"intracellular",
"proteins,",
"primarily",
"cytoskeleton",
"and",
"proteasome",
"components,",
"which",
"can",
"lead",
"to",
"cellular",
"apoptosis.",
"Together,",
"our",
"data",
"suggest",
"that",
"pep5",
"is",
"an",
"intracellular",
"peptide",
"with",
"therapeutic",
"potential",
"for",
"treating",
"specific",
"types",
"of",
"tumors",
"with",
"low",
"expression",
"of",
"Cyclin",
"D2",
"by",
"inhibiting",
"cell",
"proliferation."
] | [
0,
1,
2,
0,
1,
0,
0,
1,
1,
2,
2,
0,
1,
1,
0,
1,
2,
2,
0,
1,
2,
2,
1,
2,
0,
0,
1,
0,
1,
1,
1,
1,
0,
1,
0,
0,
1,
2,
1,
1,
2,
0,
1,
2,
2,
0,
1,
0,
1,
0,
1,
1,
2,
2,
1,
2,
0,
0,
0,
0,
1,
2,
1,
2,
2,
0,
1,
0,
1,
2,
2,
2,
1,
0,
1,
0,
1,
1,
2,
2,
2,
2,
1,
2,
1,
0,
0,
1,
2,
2,
2,
0,
0,
1,
1,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
1,
0,
1,
1,
2,
0,
1,
0,
0,
1,
1,
2,
0,
1,
0,
0,
1,
2,
0,
0,
1,
2,
1,
0,
1,
1,
1,
1,
1,
1,
2,
2,
1,
1,
0,
1,
1,
1,
0,
1,
0,
0,
2,
1,
2,
0,
0,
1,
2,
1,
1,
0,
1,
0,
0,
0,
0,
1,
0,
1,
0,
1,
0,
0,
1,
0,
1,
1,
1,
0,
1,
0,
0,
0,
0,
1,
1,
0,
0,
1,
1,
0,
0,
1,
1,
0,
0,
0,
1,
2,
0,
1,
0,
0,
0,
1,
1,
0,
1,
0,
0,
1,
0,
1,
1,
1,
0,
1,
1,
2,
0,
1,
0,
0,
1,
2,
2,
1,
0,
0,
1,
1,
0,
0,
0,
1,
2,
2,
2,
0,
0,
1,
2,
1,
1,
2,
0,
0,
0,
1,
1,
2,
2,
0,
0,
1,
2,
0,
1,
2,
0,
0,
1,
1,
2,
0,
0,
1,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
1,
1,
0,
1,
0,
1,
2,
0,
0,
1,
0,
1,
2,
0,
0,
1,
0,
0,
1,
0,
0,
1,
1,
0,
1,
1,
0,
1,
1,
2,
0,
1,
0,
1,
1,
0,
1,
2,
0,
1,
1,
2
] |
[
"Maternal",
"dietary",
"intake",
"during",
"pregnancy",
"and",
"offspring",
"body",
"composition:",
"The",
"Healthy",
"Start",
"Study",
"Consistent",
"evidence",
"of",
"an",
"influence",
"of",
"maternal",
"dietary",
"intake",
"during",
"pregnancy",
"on",
"infant",
"body",
"size",
"and",
"composition",
"in",
"human",
"populations",
"is",
"lacking,",
"despite",
"robust",
"evidence",
"in",
"animal",
"models.",
"We",
"sought",
"to",
"evaluate",
"the",
"influence",
"of",
"maternal",
"macronutrient",
"intake",
"and",
"balance",
"during",
"pregnancy",
"on",
"neonatal",
"body",
"size",
"and",
"composition,",
"including",
"fat",
"mass",
"and",
"fat-free",
"mass.",
"The",
"analysis",
"was",
"conducted",
"among",
"1040",
"mother",
"-",
"offspring",
"pairs",
"enrolled",
"in",
"the",
"prospective",
"prebirth",
"observational",
"cohort:",
"the",
"Healthy",
"Start",
"Study.",
"Diet",
"during",
"pregnancy",
"was",
"collected",
"using",
"repeated",
"24-",
"hour",
"dietary",
"recalls",
"(up",
"to",
"8).",
"Direct",
"measures",
"of",
"body",
"composition",
"were",
"obtained",
"using",
"air",
"displacement",
"plethysmography.",
"The",
"National",
"Cancer",
"Institute",
"measurement",
"error",
"model",
"was",
"used",
"to",
"estimate",
"usual",
"dietary",
"intake",
"during",
"pregnancy.",
"Multivariable",
"partition",
"(nonisocaloric)",
"and",
"nutrient",
"density",
"(isocaloric)",
"linear",
"regression",
"models",
"were",
"used",
"to",
"test",
"the",
"associations",
"between",
"maternal",
"dietary",
"intake",
"and",
"neonatal",
"body",
"composition.",
"The",
"median",
"macronutrient",
"composition",
"during",
"pregnancy",
"was",
"32.2%",
"from",
"fat,",
"15.0%",
"from",
"protein,",
"and",
"47.8%",
"from",
"carbohydrates.",
"In",
"the",
"partition",
"multivariate",
"regression",
"model,",
"individual",
"macronutrient",
"intake",
"values",
"were",
"not",
"associated",
"with",
"birthweight",
"or",
"fat-free",
"mass,",
"but",
"were",
"associated",
"with",
"fat",
"mass.",
"Respectively,",
"418",
"kJ",
"increases",
"in",
"total",
"fat,",
"saturated",
"fat,",
"unsaturated",
"fat,",
"and",
"total",
"carbohydrates",
"were",
"associated",
"with",
"4.2-g",
"(P",
"=",
".03),",
"11.1-g",
"(P",
"=",
".003),",
"5.9-g",
"(P",
"=",
".04),",
"and",
"2.9-g",
"(P",
"=",
".02)",
"increases",
"in",
"neonatal",
"fat",
"mass,",
"independent",
"of",
"prepregnancy",
"body",
"mass",
"index.",
"In",
"the",
"nutrient",
"density",
"multivariate",
"regression",
"model,",
"macronutrient",
"balance",
"was",
"not",
"associated",
"with",
"fat",
"mass,",
"fat-free",
"mass,",
"or",
"birthweight",
"after",
"adjustment",
"for",
"prepregnancy",
"body",
"mass",
"index.",
"Neonatal",
"adiposity,",
"but",
"not",
"birthweight,",
"is",
"independently",
"associated",
"with",
"increased",
"maternal",
"intake",
"of",
"total",
"fat,",
"saturated",
"fat,",
"unsaturated",
"fat,",
"and",
"total",
"carbohydrates,",
"but",
"not",
"protein,",
"suggesting",
"that",
"most",
"forms",
"of",
"increased",
"caloric",
"intake",
"contribute",
"to",
"fetal",
"fat",
"accretion."
] | [
1,
1,
2,
0,
1,
0,
1,
1,
2,
0,
1,
2,
2,
0,
1,
0,
0,
1,
0,
1,
1,
2,
0,
1,
0,
1,
1,
2,
0,
1,
0,
1,
1,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
1,
0,
1,
0,
1,
1,
1,
0,
0,
0,
1,
0,
1,
1,
2,
0,
1,
0,
1,
2,
0,
1,
2,
0,
1,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
1,
2,
2,
2,
0,
1,
2,
2,
1,
0,
1,
0,
1,
0,
0,
0,
1,
1,
0,
0,
0,
0,
1,
1,
0,
1,
2,
0,
0,
0,
1,
2,
2,
0,
1,
2,
2,
1,
2,
2,
0,
0,
0,
0,
0,
1,
2,
0,
1,
1,
2,
2,
0,
1,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
1,
1,
2,
0,
1,
1,
2,
0,
0,
1,
2,
0,
1,
0,
0,
0,
1,
0,
0,
1,
0,
0,
0,
1,
0,
0,
1,
2,
2,
2,
1,
1,
1,
1,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
2,
1,
2,
1,
2,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
2,
0,
0,
1,
2,
2,
2,
0,
0,
1,
2,
2,
2,
2,
1,
0,
0,
0,
0,
0,
1,
2,
1,
2,
0,
1,
0,
0,
0,
1,
2,
2,
2,
1,
1,
0,
0,
1,
0,
0,
0,
0,
0,
1,
1,
0,
1,
2,
1,
2,
1,
2,
0,
1,
2,
0,
0,
1,
0,
0,
0,
0,
0,
1,
1,
2,
0,
0,
1,
1,
2
] |
[
"Variation",
"in",
"the",
"Use",
"of",
"Vestibular",
"Diagnostic",
"Testing",
"for",
"Patients",
"Presenting",
"to",
"Otolaryngology",
"Clinics",
"with",
"Dizziness",
"We",
"used",
"a",
"national",
"otolaryngology",
"practice-based",
"research",
"network",
"database",
"to",
"characterize",
"the",
"utilization",
"of",
"vestibular",
"function",
"testing",
"in",
"patients",
"diagnosed",
"with",
"dizziness",
"and/or",
"a",
"vestibular",
"disorder.",
"Database",
"review.",
"The",
"Creating",
"Healthcare",
"Excellence",
"through",
"Education",
"and",
"Research",
"(CHEER)",
"practice-based",
"research",
"network",
"of",
"academic",
"and",
"community",
"providers",
"Dizzy",
"patients",
"in",
"the",
"CHEER",
"retrospective",
"database",
"were",
"identified",
"through",
"ICD-9",
"codes;",
"vestibular",
"testing",
"procedures",
"were",
"identified",
"with",
"CPT",
"codes.",
"Demographics",
"and",
"procedures",
"per",
"patient",
"were",
"tabulated.",
"Analysis",
"included",
"number",
"and",
"type",
"of",
"vestibular",
"tests",
"ordered,",
"stratified",
"by",
"individual",
"clinic",
"and",
"by",
"practice",
"type",
"(community",
"vs",
"academic).",
"Chi-square",
"tests",
"were",
"performed",
"to",
"assess",
"if",
"the",
"percentage",
"of",
"patients",
"receiving",
"testing",
"was",
"statistically",
"significant",
"across",
"clinics.",
"A",
"logistic",
"regression",
"model",
"was",
"used",
"to",
"examine",
"the",
"association",
"between",
"receipt",
"of",
"testing",
"and",
"being",
"tested",
"on",
"initial",
"visit.",
"A",
"total",
"of",
"12,468",
"patients",
"diagnosed",
"with",
"dizziness",
"and/or",
"a",
"vestibular",
"disorder",
"were",
"identified",
"from",
"7",
"community",
"and",
"5",
"academic",
"CHEER",
"network",
"clinics",
"across",
"the",
"country.",
"One-fifth",
"of",
"these",
"patients",
"had",
"at",
"least",
"1",
"vestibular",
"function",
"test.",
"The",
"percentage",
"of",
"patients",
"tested",
"varied",
"widely",
"by",
"site,",
"from",
"3%",
"to",
"72%;",
"academic",
"clinics",
"were",
"twice",
"as",
"likely",
"to",
"test.",
"Initial",
"visit",
"vestibular",
"testing",
"also",
"varied,",
"from",
"0%",
"to",
"96%",
"of",
"dizzy",
"patients,",
"and",
"was",
"15",
"times",
"more",
"likely",
"in",
"academic",
"clinics.",
"There",
"is",
"significant",
"variation",
"in",
"use",
"and",
"timing",
"of",
"vestibular",
"diagnostic",
"testing",
"across",
"otolaryngology",
"clinics.",
"The",
"CHEER",
"network",
"research",
"database",
"does",
"not",
"contain",
"outcome",
"data.",
"These",
"results",
"illustrate",
"the",
"critical",
"need",
"for",
"research",
"that",
"examines",
"outcomes",
"as",
"related",
"to",
"vestibular",
"testing."
] | [
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
0,
0,
1,
2,
0,
1,
0,
0,
0,
1,
2,
1,
2,
2,
1,
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
1,
0,
1,
0,
0,
1,
2,
0,
0,
0,
1,
2,
2,
0,
1,
0,
1,
1,
1,
2,
2,
0,
1,
0,
1,
2,
1,
2,
0,
0,
1,
1,
2,
0,
0,
0,
1,
2,
1,
2,
2,
0,
0,
0,
1,
2,
1,
0,
1,
2,
2,
0,
1,
1,
0,
0,
0,
0,
0,
1,
2,
0,
1,
2,
2,
2,
0,
0,
1,
2,
1,
0,
1,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
2,
2,
2,
0,
1,
2,
1,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
1,
0,
0,
1,
2,
0,
0,
0,
0,
1,
0,
0,
1,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
2,
0,
1,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
1,
2
] |
[
"Design",
"considerations",
"for",
"patient-specific",
"surgical",
"templates",
"for",
"total",
"hip",
"arthroplasty",
"with",
"respect",
"to",
"acetabular",
"cartilage",
"Patient-specific",
"instruments",
"(PSIs)",
"are",
"clinically",
"used",
"to",
"support",
"the",
"surgeon",
"during",
"a",
"planned",
"intervention.",
"The",
"planning",
"is",
"typically",
"done",
"based",
"on",
"volumetric",
"image",
"data",
"from",
"medical",
"imaging",
"systems,",
"e.g.",
"computed",
"tomography",
"(CT).",
"The",
"PSI",
"uses",
"the",
"known",
"surface",
"structure",
"of",
"a",
"bone",
"for",
"orientation",
"during",
"the",
"intervention.",
"Some",
"surfaces",
"of",
"human",
"bone",
"are",
"covered",
"with",
"a",
"layer",
"of",
"cartilage",
"which",
"is",
"hardly",
"visible",
"in",
"clinically",
"applied",
"CT-imaging.",
"This",
"experimental",
"study",
"investigates",
"ten",
"different",
"PSI",
"designs",
"and",
"their",
"effect",
"to",
"the",
"overall",
"accuracy",
"when",
"neglecting",
"the",
"cartilage",
"in",
"the",
"design",
"process.",
"Therefore,",
"a",
"model",
"of",
"an",
"acetabulum",
"is",
"used",
"to",
"simulate",
"the",
"use",
"case",
"of",
"PSI",
"in",
"total",
"hip",
"arthroplasty.",
"The",
"concept",
"of",
"the",
"different",
"designs",
"is",
"to",
"create",
"structural",
"elasticities",
"in",
"the",
"PSI",
"to",
"avoid",
"shifting",
"of",
"the",
"whole",
"instrument",
"and",
"rather",
"have",
"a",
"small",
"part",
"of",
"it",
"deformed",
"by",
"cartilage.",
"A",
"needle",
"array",
"structure,",
"for",
"instance,",
"should",
"also",
"be",
"able",
"to",
"oust",
"or",
"penetrate",
"remaining",
"soft",
"tissue",
"in",
"the",
"acetabulum."
] | [
1,
1,
0,
1,
1,
2,
0,
1,
2,
2,
0,
0,
0,
1,
1,
1,
2,
1,
0,
1,
0,
0,
0,
0,
1,
0,
0,
1,
2,
0,
1,
0,
0,
0,
0,
0,
1,
1,
2,
0,
1,
2,
1,
0,
1,
2,
1,
0,
1,
0,
0,
0,
1,
2,
2,
2,
2,
0,
1,
0,
0,
1,
0,
1,
2,
2,
2,
0,
1,
0,
0,
1,
0,
1,
0,
0,
1,
1,
0,
1,
1,
1,
0,
1,
2,
1,
0,
1,
1,
1,
0,
0,
1,
0,
0,
1,
1,
0,
0,
0,
1,
0,
0,
1,
1,
0,
0,
1,
0,
0,
1,
0,
0,
0,
1,
0,
0,
1,
0,
1,
0,
1,
2,
2,
0,
1,
0,
0,
1,
1,
0,
0,
1,
1,
1,
0,
0,
1,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
1
] |
[
"Fabrication",
"and",
"characterization",
"of",
"poly(vinyl",
"alcohol)",
"-",
"TiO2",
"nanocomposite",
"films",
"for",
"orthopedic",
"applications",
"Poly(vinyl",
"alcohol)",
"(PVA)",
"is",
"reinforced",
"with",
"TiO2",
"nanoparticles",
"in",
"order",
"to",
"enhance",
"thermo-mechanical",
"stabilities,",
"surface",
"characteristics",
"and",
"osteoblastic",
"cell",
"adhesion.",
"PVA",
"-",
"TiO2",
"nanocomposite",
"films",
"with",
"desirable",
"mechanical,",
"thermal",
"and",
"biocompatible",
"properties",
"are",
"fabricated",
"through",
"solution",
"casting",
"method",
"followed",
"by",
"de-hydrothermal",
"cross-linking",
"treatment.",
"The",
"composition",
"of",
"TiO2",
"nanoparticles",
"was",
"standardized",
"to",
"achieve",
"mechanically",
"stable",
"nanocomposite",
"films,",
"based",
"on",
"tensile",
"strength",
"measurements",
"composition",
"of",
"TiO2",
"is",
"determined",
"as",
"optimal",
"at",
"3wt%.",
"PVA",
"-",
"TiO2",
"nanocomposite",
"films",
"were",
"characterized",
"by",
"Scanning",
"electron",
"microscopy,",
"Energy",
"dispersive",
"spectroscopy,",
"Atomic",
"force",
"microscopy,",
"Ultra",
"violet",
"and",
"Fourier",
"transform",
"infrared",
"spectroscopic",
"techniques.",
"Elemental",
"mapping",
"studies",
"substantiate",
"incorporation",
"of",
"TiO2",
"nanoparticles",
"within",
"the",
"PVA",
"matrix.",
"Dimensional",
"stability",
"evaluated",
"by",
"soaking",
"films",
"in",
"SBF",
"for",
"24h",
"insinuates",
"the",
"role",
"of",
"TiO2",
"in",
"the",
"direction",
"of",
"controlling",
"degree",
"of",
"swelling.",
"In-vitro",
"bioactivity",
"test",
"and",
"cell",
"adhesion",
"results",
"also",
"predict",
"that",
"presence",
"of",
"TiO2",
"is",
"advantageous",
"to",
"enhance",
"apatite",
"growth",
"and",
"promote",
"cell",
"-",
"substrate",
"interaction.",
"SEM",
"studies",
"illustrate",
"improved",
"surface",
"morphology",
"of",
"PVA",
"-",
"TiO2",
"nanocomposite",
"film",
"with",
"homogenously",
"distributed",
"TiO2",
"nanoparticles,",
"which",
"help",
"to",
"enhance",
"thermo-mechanical",
"behavior.",
"TiO2",
"nanoparticles",
"construct",
"cell-adhesive",
"hydrophilic",
"nano-domains",
"that",
"act",
"as",
"potential",
"cell",
"adhesion",
"sites",
"and",
"promotes",
"osteointegration.",
"Bio",
"compatibility",
"studies",
"proved",
"that",
"thermally",
"cross-linked",
"PVA",
"is",
"non-toxic",
"in",
"relation",
"to",
"PVA",
"cross-linked",
"with",
"glutaraldehyde.",
"Cytotoxicity",
"and",
"cell",
"adhesion",
"of",
"nanocomposite",
"films",
"evaluated",
"through",
"cell",
"viability",
"(MMT)",
"assay",
"and",
"crystal",
"violet",
"staining",
"revealed",
"that",
"PVA",
"-3wt%",
"TiO2",
"nanocomposite",
"could",
"act",
"as",
"an",
"excellent",
"composite",
"and",
"hence",
"suitable",
"to",
"be",
"used",
"in",
"bone",
"implant",
"applications."
] | [
1,
0,
1,
0,
1,
2,
0,
1,
1,
1,
0,
1,
2,
1,
2,
1,
0,
0,
0,
1,
1,
0,
0,
0,
0,
1,
2,
1,
2,
0,
1,
1,
2,
1,
0,
1,
1,
1,
0,
0,
1,
1,
0,
1,
2,
0,
0,
0,
1,
2,
2,
0,
0,
1,
2,
2,
0,
1,
0,
1,
1,
0,
0,
0,
0,
1,
2,
1,
1,
0,
0,
1,
2,
1,
1,
0,
1,
0,
0,
0,
1,
0,
0,
1,
0,
1,
1,
1,
0,
1,
0,
1,
2,
2,
1,
2,
2,
1,
2,
2,
1,
2,
0,
1,
2,
2,
2,
2,
1,
2,
2,
0,
0,
0,
1,
1,
0,
0,
1,
1,
1,
2,
0,
0,
1,
1,
0,
1,
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
0,
0,
1,
2,
2,
1,
2,
2,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
1,
1,
1,
2,
0,
0,
1,
2,
0,
1,
0,
1,
1,
1,
0,
1,
1,
1,
1,
0,
0,
0,
0,
1,
2,
1,
1,
0,
1,
2,
2,
0,
0,
0,
0,
1,
2,
1,
0,
0,
1,
1,
2,
2,
0,
0,
1,
2,
1,
0,
1,
0,
0,
0,
1,
1,
0,
1,
1,
0,
1,
2,
0,
1,
1,
0,
0,
1,
2,
2,
2,
0,
1,
2,
2,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2
] |
[
"Acceleration",
"of",
"Acid-Catalyzed",
"Hydrolysis",
"in",
"a",
"Biphasic",
"System",
"by",
"Sodium",
"Tetracyanocyclopentadienides",
"The",
"hydrolysis",
"of",
"tert-butyldimethylsilyl",
"L-menthyl",
"ether",
"(3)",
"in",
"a",
"CH2Cl2",
"-1",
"M",
"HCl",
"biphasic",
"solvent",
"system",
"was",
"accelerated",
"by",
"the",
"addition",
"of",
"sodium",
"tetracyanocyclopentadienides",
"1.",
"Particularly,",
"the",
"reaction",
"rate",
"was",
"enhanced",
"using",
"sodium",
"salt",
"1a-c",
"with",
"a",
"lipophilic",
"substituent",
"on",
"the",
"cyclopentadienide",
"ring.",
"From",
"the",
"results",
"obtained",
"by",
"a",
"triphasic",
"experiment,",
"hydrolysis",
"proceeds",
"via",
"the",
"formation",
"of",
"hydronium",
"ion",
"2",
"in",
"the",
"aqueous",
"phase",
"by",
"ion",
"exchange,",
"followed",
"by",
"the",
"transfer",
"of",
"2",
"to",
"the",
"CH2Cl2",
"phase."
] | [
1,
0,
1,
1,
0,
0,
1,
2,
0,
1,
2,
0,
1,
0,
1,
2,
2,
0,
0,
0,
1,
0,
0,
1,
1,
1,
2,
0,
1,
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
2,
0,
1,
0,
1,
2,
2,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
1,
1,
0,
0,
0,
1,
0,
1,
2,
2,
0,
0,
1,
2,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2
] |
[
"A",
"novel,",
"lineage",
"-",
"primed",
"prestalk",
"cell",
"subtype",
"involved",
"in",
"the",
"morphogenesis",
"of",
"D.",
"discoideum",
"Dictyostelium",
"morphogenesis",
"requires",
"the",
"tip,",
"which",
"acts",
"as",
"an",
"organizer",
"and",
"conducts",
"orchestrated",
"cell",
"movement",
"and",
"cell",
"differentiation.",
"At",
"the",
"slug",
"stage",
"the",
"tip",
"region",
"contains",
"prestalk",
"A",
"(pstA)",
"cells,",
"which",
"are",
"usually",
"recognized",
"by",
"their",
"expression",
"of",
"reporter",
"constructs",
"that",
"utilize",
"a",
"fragment",
"of",
"the",
"promoter",
"of",
"the",
"ecmA",
"gene.",
"Here,",
"using",
"the",
"promoter",
"region",
"of",
"the",
"o-methyl",
"transferase",
"12",
"gene",
"(omt12)",
"to",
"drive",
"reporter",
"expression,",
"we",
"demonstrate",
"the",
"presence,",
"also",
"within",
"the",
"pstA",
"region,",
"of",
"a",
"novel",
"prestalk",
"cell",
"subtype:",
"the",
"pstV(A)",
"cells.",
"Surprisingly,",
"a",
"sub-population",
"of",
"the",
"vegetative",
"cells",
"express",
"a",
"pstV(A):",
"GFP",
"marker",
"and,",
"sort",
"out",
"to",
"the",
"tip,",
"both",
"when",
"developing",
"alone",
"and",
"when",
"co-developed",
"with",
"an",
"excess",
"of",
"unmarked",
"cells.",
"The",
"development",
"of",
"such",
"a",
"purified",
"GFP-marked",
"population",
"is",
"greatly",
"accelerated:",
"by",
"precocious",
"cell",
"aggregation",
"and",
"tip",
"formation",
"with",
"accompanying",
"precocious",
"elevation",
"of",
"developmental",
"gene",
"transcription.",
"We",
"therefore",
"suggest",
"that",
"the",
"tip",
"contains",
"at",
"least",
"two",
"prestalk",
"cell",
"subtypes:",
"the",
"developmentally",
"-",
"specified",
"pstA",
"cells",
"and",
"the",
"lineage",
"-",
"primed",
"pstV(A)",
"cells.",
"It",
"is",
"presumably",
"the",
"pstV(A)",
"cells",
"that",
"play",
"the",
"dominant",
"role",
"in",
"morphogenesis",
"during",
"the",
"earlier",
"stages",
"of",
"development.",
"The",
"basis",
"for",
"the",
"lineage",
"priming",
"is,",
"however,",
"unclear",
"because",
"we",
"can",
"find",
"no",
"correlation",
"between",
"pstV(A)",
"differentiation",
"and",
"nutrient",
"status",
"during",
"growth",
"or",
"cell",
"cycle",
"position",
"at",
"the",
"time",
"of",
"starvation,",
"the",
"two",
"known",
"determinants",
"of",
"probable",
"cell",
"fate."
] | [
0,
0,
1,
0,
1,
1,
2,
1,
0,
0,
0,
1,
0,
1,
2,
1,
1,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
1,
2,
2,
0,
1,
2,
0,
0,
1,
0,
0,
1,
2,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
1,
2,
0,
1,
0,
0,
1,
2,
0,
0,
0,
1,
2,
0,
0,
1,
2,
2,
2,
1,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
2,
1,
0,
1,
2,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
1,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
0,
1,
2,
0,
1,
1,
0,
0,
1,
1,
0,
1,
1,
2,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
2,
1,
0,
1,
0,
1,
2,
2,
0,
0,
1,
0,
1,
1,
2,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
1,
1,
0,
1,
0,
1,
2,
2,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
1,
2
] |
[
"NBLAST:",
"Rapid,",
"Sensitive",
"Comparison",
"of",
"Neuronal",
"Structure",
"and",
"Construction",
"of",
"Neuron",
"Family",
"Databases",
"Neural",
"circuit",
"mapping",
"is",
"generating",
"datasets",
"of",
"tens",
"of",
"thousands",
"of",
"labeled",
"neurons.",
"New",
"computational",
"tools",
"are",
"needed",
"to",
"search",
"and",
"organize",
"these",
"data.",
"We",
"present",
"NBLAST,",
"a",
"sensitive",
"and",
"rapid",
"algorithm,",
"for",
"measuring",
"pairwise",
"neuronal",
"similarity.",
"NBLAST",
"considers",
"both",
"position",
"and",
"local",
"geometry,",
"decomposing",
"neurons",
"into",
"short",
"segments;",
"matched",
"segments",
"are",
"scored",
"using",
"a",
"probabilistic",
"scoring",
"matrix",
"defined",
"by",
"statistics",
"of",
"matches",
"and",
"non-matches.",
"We",
"validated",
"NBLAST",
"on",
"a",
"published",
"dataset",
"of",
"16,129",
"single",
"Drosophila",
"neurons.",
"NBLAST",
"can",
"distinguish",
"neuronal",
"types",
"down",
"to",
"the",
"finest",
"level",
"(single",
"identified",
"neurons)",
"without",
"a",
"priori",
"information.",
"Cluster",
"analysis",
"of",
"extensively",
"studied",
"neuronal",
"classes",
"identified",
"new",
"types",
"and",
"unreported",
"topographical",
"features.",
"Fully",
"automated",
"clustering",
"organized",
"the",
"validation",
"dataset",
"into",
"1,052",
"clusters,",
"many",
"of",
"which",
"map",
"onto",
"previously",
"described",
"neuronal",
"types.",
"NBLAST",
"supports",
"additional",
"query",
"types,",
"including",
"searching",
"neurons",
"against",
"transgene",
"expression",
"patterns.",
"Finally,",
"we",
"show",
"that",
"NBLAST",
"is",
"effective",
"with",
"data",
"from",
"other",
"invertebrates",
"and",
"zebrafish."
] | [
1,
1,
1,
1,
0,
1,
1,
0,
1,
0,
1,
1,
2,
1,
2,
2,
0,
0,
1,
0,
0,
0,
0,
0,
1,
1,
0,
1,
1,
0,
0,
0,
1,
0,
1,
0,
1,
0,
0,
1,
0,
1,
0,
1,
1,
0,
1,
1,
2,
2,
1,
0,
0,
1,
0,
1,
1,
1,
1,
0,
1,
1,
1,
1,
0,
1,
0,
0,
1,
2,
2,
0,
0,
1,
0,
1,
0,
1,
0,
0,
1,
0,
0,
1,
1,
0,
0,
1,
1,
1,
1,
0,
0,
1,
1,
1,
0,
0,
1,
1,
1,
1,
1,
0,
0,
1,
2,
1,
2,
0,
0,
0,
1,
1,
1,
0,
1,
0,
1,
1,
2,
1,
2,
2,
1,
0,
1,
1,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
1,
1,
1,
0,
0,
1,
1,
0,
1,
1,
0,
1,
2,
2,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
1,
0,
1
] |
[
"Components",
"of",
"treatment",
"delay",
"in",
"rheumatoid",
"arthritis",
"differ",
"according",
"to",
"autoantibody",
"status:",
"validation",
"of",
"a",
"single-centre",
"observation",
"using",
"national",
"audit",
"data",
"To",
"determine",
"whether",
"time",
"to",
"treatment",
"following",
"symptom",
"onset",
"differs",
"between",
"RA",
"patients",
"according",
"to",
"autoantibody",
"status.",
"A",
"single-centre",
"retrospective",
"analysis",
"of",
"a",
"UK",
"early",
"RA",
"inception",
"cohort",
"was",
"first",
"undertaken",
"to",
"identify",
"those",
"components",
"of",
"the",
"patient",
"journey",
"that",
"differed",
"by",
"serological",
"subtype.",
"Data",
"from",
"a",
"UK",
"national",
"audit",
"of",
"early",
"inflammatory",
"arthritis",
"patients",
"was",
"accessed",
"to",
"replicate",
"the",
"key",
"finding.",
"A",
"total",
"of",
"173",
"RA",
"patients",
"were",
"diagnosed",
"over",
"a",
"31-",
"month",
"period,",
"of",
"whom",
"80",
"(46%)",
"were",
"ACPA/RF",
"double-seropositive",
"(ACPA(+)/RF(+)),",
"53",
"(31%)",
"ACPA(-)/RF(-),",
"17",
"(10%)",
"ACPA(+)/RF(-)",
"and",
"23",
"(13%)",
"RF(+)/ACPA(-)",
"Overall,",
"ACPA(+)/RF(+)",
"patients",
"experienced",
"significantly",
"longer",
"symptom",
"duration",
"before",
"DMARD",
"initiation.",
"This",
"was",
"accounted",
"for",
"by",
"delays",
"in",
"their",
"presentation",
"to",
"primary",
"care",
"following",
"symptom",
"onset",
"-a",
"finding",
"that",
"was",
"robustly",
"confirmed",
"in",
"an",
"independent",
"dataset",
"of",
"2192",
"UK",
"early",
"RA",
"patients.",
"In",
"contrast,",
"ACPA(-)/RF(-)",
"patients",
"were",
"significantly",
"more",
"likely",
"to",
"experience",
"delays",
"in",
"DMARD",
"initiation",
"after",
"presenting",
"to",
"secondary",
"care.",
"Causes",
"of",
"treatment",
"delays",
"in",
"early",
"RA",
"differ",
"according",
"to",
"patients",
"'",
"autoantibody",
"status.",
"More",
"insidious",
"symptom",
"onset",
"and/or",
"distinct",
"health-seeking",
"behaviours",
"among",
"ACPA(+)/RF(+)",
"patients",
"may",
"contribute",
"to",
"late",
"presentations",
"in",
"primary",
"care,",
"whereas",
"ACPA(-)/RF(-)",
"patients",
"experience",
"delayed",
"diagnosis",
"and",
"treatment",
"in",
"secondary",
"care.",
"These",
"observations",
"inform",
"the",
"research",
"agenda,",
"potentially",
"influencing",
"the",
"design",
"of",
"service",
"delivery",
"for",
"early",
"arthritis",
"patients."
] | [
0,
0,
1,
1,
0,
1,
2,
1,
0,
0,
1,
1,
1,
0,
0,
0,
1,
1,
1,
1,
1,
0,
0,
0,
1,
2,
2,
1,
1,
2,
1,
0,
1,
1,
0,
0,
1,
1,
0,
0,
1,
1,
0,
0,
1,
0,
1,
1,
2,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
1,
0,
1,
0,
1,
1,
1,
0,
0,
1,
1,
1,
0,
0,
1,
2,
1,
0,
1,
0,
1,
0,
0,
1,
0,
0,
0,
0,
1,
1,
0,
1,
1,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
2,
1,
0,
0,
1,
0,
0,
1,
0,
0,
0,
1,
0,
1,
1,
0,
0,
1,
1,
2,
0,
1,
1,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
2,
1,
1,
2,
0,
1,
0,
0,
0,
1,
0,
0,
1,
1,
0,
0,
1,
0,
1,
1,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
1,
2,
1,
0,
1,
1,
0,
0,
1,
1,
0,
0,
1,
0,
1,
1,
0,
1,
1,
2,
0,
0,
1,
2,
0,
1,
1,
0,
1,
0,
0,
0,
0,
1,
2,
0,
1,
1,
0,
1,
2,
0,
1,
0,
1,
2,
0,
1,
1,
0,
1,
2,
0,
1,
0,
1,
0,
1,
2,
0,
1,
2,
1
] |
[
"Indications",
"for",
"embolization",
"in",
"a",
"French",
"level",
"1",
"trauma",
"center",
"Abdominal",
"trauma",
"accounts",
"for",
"nearly",
"20%",
"of",
"all",
"traumatic",
"injuries.",
"It",
"often",
"involves",
"young",
"patients",
"sustaining",
"multiple",
"injuries,",
"with",
"a",
"high",
"associated",
"mortality",
"rate.",
"Management",
"should",
"begin",
"at",
"the",
"scene",
"of",
"injury",
"and",
"relies",
"on",
"a",
"structured",
"chain",
"of",
"care",
"in",
"order",
"to",
"transport",
"the",
"trauma",
"patient",
"to",
"the",
"appropriate",
"hospital",
"center.",
"Management",
"is",
"multi-disciplinary,",
"involving",
"intensive",
"care",
"specialists,",
"surgeons",
"and",
"radiologists.",
"Imaging",
"to",
"precisely",
"define",
"injury",
"is",
"best",
"performed",
"with",
"whole",
"body",
"dual",
"phase",
"computed",
"tomography,",
"which",
"can",
"also",
"identify",
"the",
"source",
"of",
"bleeding.",
"Non-operative",
"management",
"has",
"developed",
"considerably",
"over",
"the",
"years:",
"this",
"includes",
"selective",
"embolization",
"in",
"case",
"of",
"active",
"bleeding",
"or",
"vascular",
"anomalies",
"in",
"stable",
"or",
"stabilized",
"patients",
"after",
"resuscitation.",
"Embolization",
"has",
"become",
"one",
"of",
"the",
"corner",
"stones",
"of",
"abdominal",
"trauma",
"management",
"and",
"interventional",
"radiologists",
"must",
"play",
"an",
"active",
"role",
"on",
"the",
"trauma",
"team.",
"This",
"overview",
"details",
"the",
"different",
"embolization",
"procedures",
"according",
"to",
"the",
"involved",
"organ",
"and",
"embolic",
"agent",
"used."
] | [
1,
0,
1,
0,
0,
1,
2,
2,
2,
2,
1,
2,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
1,
1,
1,
2,
0,
0,
0,
0,
1,
2,
1,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
1,
2,
1,
0,
1,
0,
1,
2,
2,
1,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
1,
1,
2,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
0,
0,
0,
1,
2,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
2,
0
] |
[
"A",
"novel",
"functional",
"full-fat",
"hard",
"cheese",
"containing",
"liposomal",
"nanoencapsulated",
"green",
"tea",
"catechins:",
"manufacture",
"and",
"recovery",
"following",
"simulated",
"digestion",
"(+)-Catechin",
"or",
"green",
"tea",
"extract",
"were",
"encapsulated",
"in",
"soy",
"lecithin",
"nanoliposomes",
"and",
"incorporated",
"into",
"a",
"full-fat",
"cheese,",
"then",
"ripened",
"at",
"8",
"°C",
"for",
"90",
"days.",
"Cheese",
"samples",
"were",
"subjected",
"to",
"simulated",
"gastrointestinal",
"digestion",
"to",
"measure",
"total",
"phenolic",
"conten",
"t",
"(TPC)",
"and",
"antioxidant",
"activity",
"of",
"the",
"cheese",
"digesta,",
"and",
"to",
"determine",
"the",
"catechin",
"recovery",
"after",
"digestion",
"by",
"high",
"performance",
"liquid",
"chromatography",
"(HPLC).",
"Addition",
"of",
"catechin",
"or",
"green",
"tea",
"extract",
"significantly",
"(P",
"≤",
"0.05)",
"increased",
"TPC",
"and",
"antioxidant",
"activity",
"(measured",
"by",
"ferric",
"reducing",
"antioxidant",
"power",
"and",
"oxygen",
"radical",
"absorbance",
"capacity)",
"of",
"the",
"full-fat",
"cheese",
"without",
"affecting",
"pH",
"or",
"proximate",
"composition.",
"HPLC",
"analysis",
"confirmed",
"retention",
"of",
"encapsulated",
"catechins",
"in",
"the",
"cheese",
"curd;",
"however,",
"individual",
"catechins",
"were",
"recovered",
"in",
"differing",
"amounts",
"(15-52%)",
"from",
"cheese",
"digesta",
"after",
"6",
"h",
"of",
"digestion.",
"Transmission",
"electron",
"microscopy",
"and",
"Fourier",
"transform",
"infrared",
"spectroscopy",
"provided",
"evidence",
"for",
"association",
"of",
"nanoliposomes",
"with",
"the",
"surface",
"of",
"milk",
"fat",
"globules",
"inside",
"the",
"cheese",
"matrix.",
"The",
"study",
"shows",
"the",
"potential",
"for",
"using",
"cheese",
"as",
"a",
"delivery",
"vehicle",
"for",
"green",
"tea",
"antioxidants."
] | [
0,
0,
0,
1,
2,
2,
0,
1,
1,
1,
2,
2,
1,
0,
1,
0,
1,
1,
1,
0,
1,
2,
2,
0,
1,
0,
1,
2,
1,
0,
0,
0,
0,
1,
2,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
1,
2,
0,
0,
1,
1,
2,
0,
1,
0,
1,
2,
0,
0,
1,
1,
0,
0,
0,
0,
1,
1,
0,
1,
0,
1,
2,
2,
2,
1,
1,
0,
1,
0,
1,
2,
2,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
1,
2,
2,
2,
0,
1,
2,
2,
2,
0,
0,
1,
2,
0,
1,
1,
0,
1,
2,
1,
2,
0,
1,
0,
1,
1,
0,
0,
1,
2,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
1,
1,
2,
2,
0,
1,
2,
2,
2,
0,
1,
0,
1,
0,
1,
0,
0,
1,
0,
1,
2,
2,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
0,
1,
2,
2
] |
[
"Plasmablastic",
"transformation",
"of",
"plasma",
"cell",
"myeloma",
"with",
"heterotropic",
"expression",
"of",
"CD3",
"and",
"CD4:",
"a",
"case",
"report",
"Plasmablastic",
"lymphoma",
"(PBL)",
"can",
"rarely",
"be",
"seen",
"as",
"a",
"transformation",
"from",
"plasma",
"cell",
"myeloma",
"(PCM),",
"especially",
"in",
"late",
"stages",
"of",
"the",
"disease",
"where",
"it",
"portends",
"a",
"poorer",
"prognosis",
"and",
"a",
"different",
"line",
"of",
"management",
"for",
"the",
"patient.",
"When",
"unrelated",
"to",
"PCM,",
"PBL",
"is",
"considered",
"to",
"be",
"a",
"separate",
"aggressive",
"variant",
"of",
"B-cell",
"lymphoma",
"typically",
"seen",
"in",
"the",
"oral",
"cavity",
"of",
"immunocompromised",
"adults.",
"We",
"describe",
"a",
"case",
"of",
"plasmablastic",
"transformation",
"having",
"a",
"pan",
"T-cell",
"phenotype",
"with",
"CD3",
"and",
"CD4",
"positivity,",
"in",
"an",
"immunocompetent",
"elderly",
"lady",
"diagnosed",
"with",
"PCM.",
"This",
"60-",
"year",
"-",
"old",
"lady",
"presented",
"with",
"worsening",
"backache",
"and",
"a",
"2-cm",
"skin",
"nodule",
"in",
"the",
"left",
"cervical",
"region,",
"while",
"she",
"was",
"on",
"treatment",
"with",
"vincristine,",
"cyclophosphamide,",
"dexamethasone",
"(VCD),",
"and",
"bortezomib.",
"On",
"biopsy,",
"the",
"skin",
"nodule",
"showed",
"an",
"infiltrating",
"lymphoid",
"tumor",
"composed",
"of",
"immunoblastic",
"cells",
"with",
"brisk",
"mitosis",
"and",
"apoptosis.",
"On",
"Immunohistochemistry",
"(IHC),",
"lymphoid",
"cells",
"revealed",
"plasma",
"cell",
"markers",
"CD38,",
"CD138,",
"CD56,",
"and",
"MUM1.",
"Pan-T-cell",
"markers",
"CD3",
"and",
"CD4",
"were",
"also",
"diffusely",
"expressed",
"in",
"tumor",
"cells.",
"B-cell",
"markers",
"CD20",
"and",
"PAX5",
"were",
"not",
"expressed;",
"c-Myc",
"IHC",
"and",
"EBER",
"by",
"in",
"situ",
"hybridization",
"(ISH)",
"were",
"negative",
"in",
"the",
"tumor.",
"Mitotic",
"index",
"by",
"Ki67",
"was",
">95%.",
"Thus,",
"a",
"diagnosis",
"of",
"plasmablastic",
"transformation",
"in",
"a",
"known",
"PCM",
"case",
"was",
"made.",
"This",
"is",
"the",
"first",
"case,",
"to",
"the",
"best",
"of",
"our",
"knowledge,",
"with",
"a",
"heterotropic",
"T-cell",
"phenotype",
"in",
"a",
"plasmablastic",
"transformation",
"from",
"PCM.",
"It",
"is",
"critical",
"to",
"correctly",
"diagnose",
"such",
"cases",
"as",
"they",
"may",
"occasionally",
"be",
"misinterpreted",
"as",
"T-cell",
"neoplasms.",
"Clinically,",
"a",
"more",
"aggressive",
"treatment",
"is",
"indicated",
"for",
"such",
"patients.",
"Further",
"studies",
"in",
"these",
"cases",
"may",
"enhance",
"our",
"understanding",
"of",
"complex",
"underpinnings",
"of",
"lymphoma",
"biology."
] | [
1,
2,
0,
1,
2,
2,
0,
1,
2,
0,
1,
0,
1,
0,
1,
2,
1,
2,
1,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
2,
1,
0,
0,
1,
2,
0,
0,
1,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
1,
2,
0,
1,
2,
0,
0,
0,
0,
1,
2,
0,
1,
1,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
2,
2,
0,
1,
0,
1,
0,
0,
0,
1,
1,
2,
1,
0,
1,
0,
0,
1,
0,
1,
2,
0,
0,
1,
1,
0,
0,
0,
1,
2,
0,
0,
1,
2,
2,
0,
0,
0,
0,
1,
0,
1,
1,
1,
1,
0,
1,
0,
1,
0,
1,
2,
0,
0,
1,
1,
2,
0,
0,
1,
2,
0,
0,
1,
0,
1,
0,
1,
1,
1,
2,
0,
1,
2,
1,
1,
1,
1,
0,
1,
1,
2,
1,
0,
1,
0,
0,
1,
2,
0,
1,
2,
1,
2,
1,
0,
1,
0,
0,
0,
1,
1,
0,
1,
0,
1,
2,
2,
1,
0,
1,
0,
0,
1,
1,
2,
0,
1,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
2,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
1,
0,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
0,
1,
0,
0,
0,
1,
1,
0,
1,
1
] |
[
"pH",
"affects",
"bacterial",
"community",
"composition",
"in",
"soils",
"across",
"the",
"Huashan",
"Watershed,",
"China",
"To",
"investigate",
"soil",
"bacterial",
"richness",
"and",
"diversity",
"and",
"to",
"determine",
"the",
"correlations",
"between",
"bacterial",
"communities",
"and",
"soil",
"properties,",
"8",
"soil",
"samples",
"were",
"collected",
"from",
"the",
"Huashan",
"watershed",
"in",
"Anhui,",
"China.",
"Subsequently,",
"454",
"high-throughput",
"pyrosequencing",
"and",
"bioinformatics",
"analyses",
"were",
"performed",
"to",
"examine",
"the",
"soil",
"bacterial",
"community",
"compositions.",
"The",
"operational",
"taxonomic",
"unit",
"richness",
"of",
"the",
"bacterial",
"community",
"ranged",
"from",
"3664",
"to",
"5899,",
"and",
"the",
"diversity",
"indices,",
"including",
"Chao1,",
"Shannon-Wiener,",
"and",
"Faith's",
"phylogenetic",
"diversity",
"ranged",
"from",
"7751",
"to",
"15",
"204,",
"7.386",
"to",
"8.327,",
"and",
"415.77",
"to",
"679.11,",
"respectively.",
"The",
"2",
"most",
"dominant",
"phyla",
"in",
"the",
"soil",
"samples",
"were",
"Actinobacteria",
"and",
"Proteobacteria.",
"The",
"richness",
"and",
"diversity",
"of",
"the",
"bacterial",
"community",
"were",
"positively",
"correlated",
"with",
"soil",
"pH.",
"The",
"Mantel",
"test",
"revealed",
"that",
"the",
"soil",
"pH",
"was",
"the",
"dominant",
"factor",
"influencing",
"the",
"bacterial",
"community.",
"The",
"positive",
"modular",
"structure",
"of",
"co-occurrence",
"patterns",
"at",
"the",
"genus",
"level",
"was",
"discovered",
"by",
"network",
"analysis.",
"The",
"results",
"obtained",
"in",
"this",
"study",
"provide",
"useful",
"information",
"that",
"enhances",
"our",
"understanding",
"of",
"the",
"effects",
"of",
"soil",
"properties",
"on",
"the",
"bacterial",
"communities."
] | [
1,
0,
1,
1,
1,
0,
1,
0,
0,
1,
2,
1,
0,
0,
1,
1,
1,
0,
1,
0,
0,
0,
0,
1,
0,
1,
1,
0,
1,
1,
0,
1,
2,
0,
0,
0,
0,
1,
2,
0,
1,
1,
0,
0,
1,
2,
0,
1,
2,
0,
0,
0,
0,
0,
1,
1,
1,
1,
0,
1,
2,
2,
1,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
1,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
0,
1,
0,
1,
0,
1,
0,
1,
0,
0,
1,
1,
0,
0,
0,
0,
1,
1,
0,
1,
2,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
1,
2,
0,
1,
2,
0,
0,
1,
1,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
1,
1
] |
[
"Long-term",
"lamivudine",
"therapy",
"in",
"chronic",
"hepatitis",
"B",
"One",
"to",
"5",
"years",
"of",
"therapy",
"of",
"chronic",
"hepatitis",
"B",
"with",
"oral",
"nucleoside",
"analogues",
"result",
"in",
"significant",
"clinical",
"improvements,",
"but",
"effects",
"of",
"more",
"prolonged",
"therapy",
"are",
"not",
"well",
"defined.",
"To",
"describe",
"outcomes",
"of",
"chronic",
"hepatitis",
"B",
"with",
"long-term",
"lamivudine",
"therapy.",
"Forty-two",
"patients",
"with",
"chronic",
"hepatitis",
"B",
"treated",
"with",
"lamivudine",
"were",
"followed",
"for",
"3.2-19.5",
"(median",
"=",
"16.1)",
"years.",
"Therapy",
"was",
"switched",
"to",
"other",
"agents",
"(n",
"=",
"16)",
"if",
"patients",
"developed",
"lamivudine",
"resistance",
"and",
"relapse",
"of",
"disease.",
"Among",
"22",
"HBeAg-positive",
"patients,",
"17",
"(77%)",
"became",
"HBeAg",
"negative,",
"of",
"whom",
"5",
"(23%)",
"subsequently",
"cleared",
"HBsAg.",
"Among",
"20",
"HBeAg-negative",
"patients,",
"10",
"(50%)",
"cleared",
"HBsAg.",
"The",
"time",
"to",
"HBsAg",
"clearance",
"ranged",
"from",
"0.9",
"to",
"16.8",
"(median",
"=",
"9.3)",
"years.",
"Lamivudine",
"resistance",
"arose",
"in",
"24",
"patients",
"(57%)",
"of",
"whom",
"6",
"(25%)",
"lost",
"HBsAg.",
"HBsAg",
"clearance",
"was",
"not",
"always",
"accompanied",
"by",
"seroconversion;",
"anti-HBs",
"appearing",
"concurrently",
"in",
"only",
"five",
"patients",
"(33%).",
"Nevertheless,",
"HBsAg",
"loss",
"allowed",
"for",
"stopping",
"therapy",
"in",
"all",
"patients,",
"none",
"re-developing",
"HBsAg",
"or",
"suffering",
"relapse;",
"all",
"having",
"normal",
"alanine",
"aminotransferase",
"levels",
"and",
"no",
"(n",
"=",
"13)",
"or",
"unquantifiable",
"HBV",
"DNA",
"levels",
"(n",
"=",
"2)",
"when",
"last",
"seen.",
"In",
"contrast,",
"seven",
"of",
"27",
"patients",
"(26%)",
"who",
"remained",
"HBsAg-positive",
"died",
"of",
"liver",
"disease",
"or",
"liver",
"cancer",
"or",
"underwent",
"liver",
"transplantation,",
"all",
"of",
"whom",
"had",
"cirrhosis.",
"Long-term",
"viral",
"suppression",
"with",
"nucleoside",
"analogues",
"leads",
"to",
"HBsAg",
"loss",
"in",
"a",
"substantial",
"proportion",
"of",
"patients,",
"particularly",
"if",
"HBeAg-negative.",
"Serious",
"outcomes",
"during",
"the",
"first",
"10-20",
"years",
"of",
"treatment",
"occur",
"largely",
"among",
"patients",
"with",
"pre-existing",
"cirrhosis",
"who",
"do",
"not",
"clear",
"HBsAg",
"with",
"therapy."
] | [
1,
2,
2,
0,
1,
2,
2,
0,
0,
0,
0,
0,
1,
0,
1,
2,
2,
0,
1,
1,
2,
0,
0,
0,
1,
1,
0,
1,
2,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
2,
0,
1,
2,
2,
0,
1,
0,
1,
2,
2,
1,
2,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
1,
1,
0,
1,
2,
2,
0,
0,
1,
1,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
1,
0,
0,
1,
1,
0,
0,
1,
1,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
1,
0,
0,
1,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
1,
0,
1,
2,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
0,
1,
1,
1,
1,
0,
1,
2,
0,
0,
1,
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
1,
1,
0,
1
] |
[
"The",
"Enigma",
"of",
"the",
"Dichotomic",
"Pressure",
"Response",
"of",
"GluN1-4a",
"/",
"b",
"Splice",
"Variants",
"of",
"NMDA",
"Receptor:",
"Experimental",
"and",
"Statistical",
"Analyses",
"Professional",
"deep-water",
"divers,",
"exposed",
"to",
"hyperbaric",
"pressure",
"(HP)",
"above",
"1.1",
"MPa,",
"develop",
"High",
"Pressure",
"Neurological",
"Syndrome",
"(HPNS),",
"which",
"is",
"associated",
"with",
"central",
"nervous",
"system",
"(CNS)",
"hyperexcitability.",
"It",
"was",
"previously",
"reported",
"that",
"HP",
"augments",
"N-methyl-D-aspartate",
"receptor",
"(NMDAR)",
"synaptic",
"response,",
"increases",
"neuronal",
"excitability",
"and",
"potentially",
"causes",
"irreversible",
"neuronal",
"damage.",
"Our",
"laboratory",
"has",
"reported",
"differential",
"current",
"responses",
"under",
"HP",
"conditions",
"in",
"NMDAR",
"subtypes",
"that",
"contain",
"either",
"GluN1-1a",
"or",
"GluN1-1b",
"splice",
"variants",
"co-expressed",
"in",
"Xenopus",
"laevis",
"oocytes",
"with",
"all",
"four",
"GluN2",
"subunits.",
"Recently,",
"we",
"reported",
"that",
"the",
"increase",
"in",
"ionic",
"currents",
"measured",
"under",
"HP",
"conditions",
"is",
"also",
"dependent",
"on",
"which",
"of",
"the",
"eight",
"splice",
"variants",
"of",
"GluN1",
"is",
"co-expressed",
"with",
"the",
"GluN2",
"subunit.",
"We",
"now",
"report",
"that",
"the",
"NMDAR",
"subtype",
"that",
"contains",
"GluN1-4a/b",
"splice",
"variants",
"exhibited",
"\"dichotomic\"",
"(either",
"increased",
"or",
"decreased)",
"response",
"s",
"at",
"HP.",
"The",
"distribution",
"of",
"the",
"results",
"is",
"not",
"normal",
"thus",
"analysis",
"of",
"variance",
"(ANOVA)",
"test",
"and",
"clustering",
"analysis",
"were",
"employed",
"for",
"statistical",
"verification",
"of",
"the",
"grouping.",
"Furthermore,",
"the",
"calculated",
"constants",
"of",
"alpha",
"function",
"distribution",
"analysis",
"for",
"the",
"two",
"groups",
"were",
"similar,",
"suggesting",
"that",
"the",
"mechanism",
"underlying",
"the",
"switch",
"between",
"an",
"increase",
"or",
"a",
"decrease",
"of",
"the",
"current",
"at",
"HP",
"is",
"a",
"single",
"process,",
"the",
"nature",
"of",
"which",
"is",
"still",
"unknown.",
"This",
"dichotomic",
"response",
"of",
"the",
"GluN1-4a",
"/",
"b",
"splice",
"variant",
"may",
"be",
"used",
"as",
"a",
"model",
"for",
"studying",
"reduced",
"response",
"in",
"NMDAR",
"at",
"HP.",
"Successful",
"reversal",
"of",
"other",
"NMDAR",
"subtypes",
"response",
"(i.e.,",
"current",
"reduction)",
"may",
"allow",
"the",
"elimination",
"of",
"the",
"reversible",
"malfunctioning",
"short",
"term",
"effects",
"(HPNS),",
"or",
"even",
"deleterious",
"long",
"term",
"effects",
"induced",
"by",
"increased",
"NMDAR",
"function",
"during",
"HP",
"exposure."
] | [
0,
0,
0,
0,
1,
2,
1,
0,
1,
0,
1,
1,
2,
0,
1,
2,
1,
0,
1,
2,
1,
2,
2,
0,
0,
1,
2,
1,
0,
0,
0,
0,
1,
2,
2,
2,
1,
0,
0,
1,
2,
1,
2,
2,
1,
1,
0,
0,
0,
0,
0,
1,
0,
1,
2,
1,
1,
2,
1,
1,
1,
0,
0,
0,
1,
1,
2,
0,
1,
0,
0,
1,
2,
1,
0,
1,
1,
0,
1,
1,
0,
0,
0,
1,
0,
1,
1,
2,
1,
0,
1,
2,
1,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
1,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
1,
1,
2,
0,
0,
0,
1,
0,
1,
1,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
2,
2,
1,
0,
0,
1,
2,
0,
0,
0,
1,
2,
0,
0,
1,
0,
0,
1,
1,
0,
1,
2,
1,
2,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
1,
0,
1,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
1,
1,
2,
0,
0,
0,
0,
0,
1,
0,
0,
1,
1,
0,
1,
0,
1,
0,
1,
0,
0,
1,
1,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
1,
1,
1,
2,
1,
1,
0,
0,
0,
1,
2,
1,
0,
0,
1,
1,
0,
0,
1,
1
] |
[
"Matrix",
"metalloproteinase-9",
"Gene-1562C>T",
"Gene",
"Polymorphism",
"and",
"Coronary",
"Artery",
"Disease",
"in",
"the",
"Chinese",
"Han",
"Population:",
"A",
"Meta-Analysis",
"of",
"5468",
"Subjects",
"Multiple",
"studies",
"indicate",
"that",
"the",
"matrix",
"metalloproteinase-9",
"(MMP-9)-1562C>T",
"gene",
"polymorphism",
"may",
"be",
"associated",
"with",
"an",
"increased",
"risk",
"of",
"coronary",
"artery",
"disease",
"(CAD)",
"in",
"the",
"Chinese",
"Han",
"population.",
"However,",
"a",
"clear",
"consensus",
"has",
"yet",
"to",
"be",
"established.",
"A",
"meta-analysis",
"of",
"5468",
"subjects",
"from",
"10",
"separate",
"studies",
"was",
"performed",
"to",
"explore",
"the",
"possible",
"relationship",
"between",
"the",
"MMP-9-1562C>T",
"gene",
"polymorphism",
"and",
"CAD",
"within",
"the",
"Chinese",
"Han",
"population.",
"Pooled",
"odds",
"ratio",
"(ORs)",
"for",
"the",
"association",
"and",
"the",
"corresponding",
"95%",
"confidence",
"intervals",
"(CIs)",
"were",
"evaluated",
"by",
"a",
"random",
"or",
"fixed-effect",
"model.",
"Our",
"analysis",
"confirms",
"the",
"association",
"between",
"the",
"MMP-9-1562C>T",
"gene",
"polymorphism",
"and",
"an",
"increased",
"risk",
"of",
"CAD",
"within",
"the",
"Chinese",
"Han",
"population",
"under",
"allelic",
"(OR:",
"1.60,",
"95%",
"CI:",
"1.25-2.04,",
"P",
"=",
"0.0002),",
"recessive",
"(OR:",
"3.05,",
"95%",
"CI:",
"1.67-5.56,",
"P",
"=",
"0.0003),",
"dominant",
"(OR:",
"2.23,",
"95%",
"CI:",
"1.49-3.35,",
"P",
"=",
"0.0001),",
"homozygous",
"(OR:",
"3.41,",
"95%",
"CI:",
"1.87-6.23,",
"P",
"<",
"0.0001),",
"heterozygous",
"(OR:",
"2.03,",
"95%",
"CI:",
"1.40-2.93,",
"P",
"=",
"0.0002),",
"and",
"additive",
"genetic",
"models",
"(OR:",
"1.78,",
"95%",
"CI:",
"1.33-2.39,",
"P",
"<",
"0.0001).",
"In",
"the",
"Chinese",
"Han",
"population,",
"the",
"MMP-9-1562C>T",
"gene",
"polymorphism",
"is",
"correlated",
"with",
"an",
"increased",
"risk",
"of",
"CAD.",
"Therefore,",
"Han",
"Chinese",
"carriers",
"of",
"the",
"-",
"1562T",
"allele",
"may",
"be",
"at",
"an",
"increased",
"risk",
"of",
"CAD."
] | [
1,
2,
2,
2,
1,
0,
1,
2,
2,
0,
0,
1,
2,
2,
0,
1,
0,
0,
1,
0,
1,
0,
0,
0,
1,
2,
2,
2,
1,
0,
0,
1,
2,
0,
1,
2,
0,
1,
2,
2,
1,
0,
0,
1,
2,
2,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
1,
0,
1,
0,
0,
1,
2,
2,
1,
2,
2,
1,
0,
0,
0,
0,
0,
0,
0,
1,
2,
1,
0,
0,
0,
0,
1,
0,
1,
2,
0,
1,
0,
0,
0,
0,
0,
1,
2,
1,
0,
0,
1,
2,
0,
1,
0,
0,
1,
2,
2,
0,
1,
1,
0,
0,
1,
0,
0,
0,
0,
1,
1,
0,
0,
1,
0,
0,
0,
0,
1,
1,
0,
0,
1,
0,
0,
0,
0,
1,
1,
0,
0,
1,
0,
0,
0,
0,
1,
1,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
1,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
2,
1,
0,
1,
0,
0,
1,
2,
0,
1,
0,
1,
2,
1,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
2,
0,
1
] |
[
"Variability",
"in",
"Saponin",
"Content,",
"Cancer",
"Antiproliferative",
"Activity",
"and",
"Physicochemical",
"Properties",
"of",
"Concentrated",
"Agave",
"Sap",
"Concentrated",
"agave",
"sap",
"(CAS)",
"has",
"gained",
"popularity",
"as",
"an",
"unrefined",
"sweetener.",
"It",
"is",
"obtained",
"by",
"boiling",
"\"",
"aguamiel",
"\"",
"that",
"contains",
"phytochemicals",
"with",
"diverse",
"bioactivities.",
"Saponins",
"have",
"been",
"the",
"most",
"widely",
"studied",
"agave",
"phytochemicals",
"due",
"to",
"their",
"cancer",
"antiproliferative",
"effect",
"but",
"their",
"concentration",
"may",
"vary",
"due",
"to",
"maturity",
"of",
"the",
"agave",
"plant",
"and",
"collection",
"site.",
"In",
"this",
"study,",
"18",
"CAS",
"samples",
"produced",
"in",
"different",
"states",
"of",
"Mexico",
"were",
"analyzed",
"using",
"multivariate",
"methods",
"to",
"determine",
"which",
"physicochemical",
"or",
"phytochemical",
"parameters",
"were",
"responsible",
"for",
"variation.",
"Additionally,",
"extracts",
"with",
"different",
"saponin",
"profiles",
"were",
"tested",
"to",
"determine",
"possible",
"correlations",
"with",
"antiproliferative",
"activity.",
"Total",
"soluble",
"solids,",
"pH,",
"and",
"water",
"activity",
"were",
"similar",
"to",
"those",
"reported",
"for",
"other",
"agave",
"sweeteners.",
"Antioxidant",
"capacity",
"of",
"samples",
"was",
"correlated",
"to",
"browning",
"index.",
"Eleven",
"steroidal",
"saponins",
"were",
"found",
"in",
"CAS",
"samples",
"and",
"they",
"were",
"the",
"main",
"source",
"of",
"variability.",
"Magueyoside",
"B,",
"a",
"kammogenin",
"tetraglycoside,",
"was",
"the",
"most",
"abundant",
"saponin",
"in",
"all",
"samples.",
"With",
"respect",
"to",
"bioactivity,",
"multivariate",
"analysis",
"indicated",
"that",
"magueyoside",
"B",
"and",
"a",
"gentrogenin",
"tetraglycoside",
"were",
"compounds",
"strongly",
"related",
"with",
"bioactivity.",
"CAS",
"from",
"Hidalgo,",
"Puebla,",
"and",
"Veracruz",
"had",
"higher",
"concentration",
"of",
"magueyoside",
"B",
"than",
"from",
"the",
"other",
"kamogenin",
"tetraglycoside",
"found",
"in",
"the",
"samples",
"from",
"other",
"Mexican",
"states.",
"These",
"results",
"could",
"be",
"used",
"as",
"a",
"first",
"approach",
"to",
"characterize",
"and",
"standardize",
"CAS",
"to",
"validate",
"the",
"potential",
"health",
"benefits",
"derived",
"from",
"its",
"consumption."
] | [
1,
0,
1,
1,
1,
1,
2,
0,
1,
2,
0,
1,
2,
2,
1,
2,
2,
1,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
1,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
1,
1,
2,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
1,
2,
0,
1,
1,
0,
0,
1,
0,
1,
1,
0,
0,
1,
1,
0,
1,
0,
1,
0,
1,
2,
0,
0,
0,
1,
0,
1,
2,
0,
1,
0,
1,
0,
1,
0,
1,
1,
1,
0,
1,
0,
0,
0,
1,
0,
1,
2,
1,
2,
2,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
1,
1,
1,
2,
0,
1,
0,
1,
0,
1,
2,
0,
1,
2,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
0,
1,
1,
2,
0,
1,
2,
0,
0,
0,
1,
1,
0,
0,
1,
0,
0,
0,
1,
1,
2,
0,
0,
1,
2,
0,
0,
1,
2,
0,
1,
0,
0,
0,
1,
1,
0,
1,
1,
0,
1,
0,
1,
1,
0,
1,
2,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1
] |
[
"Association",
"of",
"CDKAL1,",
"CDKN2A",
"/",
"B",
"&",
"HHEX",
"gene",
"polymorphisms",
"with",
"type",
"2",
"diabetes",
"mellitus",
"in",
"the",
"population",
"of",
"Hyderabad,",
"India",
"The",
"genome-wide",
"association",
"studies",
"(GWAS)",
"have",
"shown",
"an",
"association",
"of",
"type",
"2",
"diabetes",
"mellitus",
"(T2DM)",
"with",
"several",
"novel",
"genes.",
"We",
"report",
"here",
"the",
"findings",
"on",
"the",
"pattern",
"of",
"genetic",
"association",
"of",
"three",
"genes",
"(CDKAL1,",
"CDKN2A",
"/",
"B",
"and",
"HHEX)",
"with",
"T2DM",
"in",
"the",
"population",
"of",
"Hyderabad,",
"south",
"India.",
"A",
"sample",
"of",
"1379",
"individuals",
"(758",
"T2DM",
"cases",
"and",
"621",
"controls)",
"from",
"Hyderabad,",
"India,",
"were",
"genotyped",
"for",
"five",
"single",
"nucleotide",
"polymorphisms",
"(SNPs)",
"of",
"CDKAL1",
"(rs7754840,",
"rs7756992)",
"CDKN2A",
"/",
"B",
"(rs10811661)",
"and",
"HHEX",
"(rs1111875,",
"rs7923837)",
"genes",
"on",
"Sequenom",
"Mass",
"Array",
"platform.",
"The",
"risk",
"allele",
"frequencies",
"of",
"the",
"CDKAL1",
"and",
"CDKN2A",
"/",
"B",
"SNPs",
"were",
"relatively",
"higher",
"in",
"cases",
"than",
"in",
"the",
"controls",
"and",
"the",
"logistic",
"regression",
"analysis",
"yielded",
"significant",
"odds",
"ratios",
"suggesting",
"that",
"the",
"variant",
"alleles",
"conferred",
"risk",
"for",
"developing",
"T2DM",
"in",
"this",
"population.",
"The",
"HHEX",
"gene",
"did",
"not",
"show",
"either",
"allelic",
"or",
"genotypic",
"association",
"with",
"T2DM.",
"The",
"multivariate",
"logistic",
"regression",
"analysis",
"with",
"reference",
"to",
"both",
"alleles",
"and",
"genotypes",
"of",
"CDKAL1",
"SNPs",
"showed",
"significant",
"association,",
"suggesting",
"an",
"important",
"role",
"for",
"this",
"gene",
"in",
"the",
"T2DM",
"pathophysiology.",
"A",
"significant",
"association",
"was",
"seen",
"of",
"all",
"the",
"three",
"SNPs",
"of",
"CDKAL1",
"and",
"CDKN2A",
"/",
"B",
"genes",
"with",
"T2DM",
"but",
"none",
"of",
"the",
"two",
"SNPs",
"of",
"HHEX.",
"Further",
"studies",
"are",
"required",
"to",
"cross-validate",
"our",
"findings",
"in",
"a",
"relatively",
"larger",
"sample.",
"It",
"is",
"also",
"necessary",
"to",
"explore",
"other",
"SNPs",
"of",
"HHEX",
"gene",
"to",
"unequivocally",
"establish",
"the",
"pattern",
"of",
"association",
"of",
"this",
"gene",
"with",
"T2DM",
"in",
"this",
"population."
] | [
1,
0,
1,
1,
0,
1,
0,
1,
1,
2,
0,
1,
2,
2,
2,
0,
0,
1,
0,
1,
1,
0,
1,
2,
2,
1,
0,
0,
0,
1,
0,
1,
2,
2,
2,
1,
0,
0,
1,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
2,
0,
0,
1,
1,
1,
0,
1,
0,
1,
0,
1,
0,
0,
1,
0,
1,
0,
1,
0,
1,
0,
0,
1,
0,
1,
0,
0,
0,
1,
0,
1,
1,
0,
1,
0,
0,
1,
2,
2,
1,
0,
1,
2,
2,
1,
0,
1,
2,
0,
1,
2,
2,
2,
0,
1,
2,
2,
2,
0,
1,
1,
2,
0,
0,
1,
0,
1,
0,
1,
1,
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
2,
0,
0,
1,
2,
0,
0,
0,
1,
1,
0,
1,
0,
0,
1,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
1,
0,
1,
0,
1,
1,
2,
2,
0,
0,
0,
0,
1,
0,
1,
0,
1,
1,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
1,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
1,
0,
1,
2,
0,
1,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
0,
0,
1
] |
[
"Mandibular",
"dysostosis",
"without",
"microphthalmia",
"caused",
"by",
"OTX2",
"deletion",
"Mutations",
"in",
"OTX2",
"are",
"mostly",
"identified",
"in",
"patients",
"with",
"anophthalmia",
"/",
"microphthalmia",
"with",
"variable",
"severity.",
"The",
"OTX2",
"homeobox",
"gene",
"plays",
"a",
"crucial",
"role",
"in",
"craniofacial",
"morphogenesis",
"during",
"early",
"embryo",
"development.",
"We",
"report",
"for",
"the",
"first",
"time",
"a",
"patient",
"with",
"a",
"mandibular",
"dysostosis",
"caused",
"by",
"a",
"120",
"kb",
"deletion",
"including",
"the",
"entire",
"coding",
"sequence",
"of",
"OTX2,",
"identified",
"by",
"array",
"CGH.",
"No",
"ocular",
"malformations",
"were",
"identified",
"after",
"extended",
"ophthalmologic",
"examination.",
"Our",
"data",
"refine",
"the",
"clinical",
"spectrum",
"associated",
"with",
"OTX2",
"mutations",
"and",
"suggests",
"that",
"OTX2",
"haploinsufficiency",
"should",
"be",
"considered",
"as",
"a",
"possible",
"cause",
"for",
"isolated",
"mandibular",
"dysostosis.",
"©",
"2016",
"Wiley",
"Periodicals,",
"Inc."
] | [
1,
2,
0,
1,
1,
2,
1,
2,
1,
0,
1,
0,
0,
1,
0,
1,
0,
1,
0,
1,
0,
1,
2,
0,
1,
2,
2,
0,
0,
0,
0,
0,
1,
1,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
1,
2,
0,
1,
2,
2,
0,
0,
1,
2,
2,
2,
2,
1,
0,
1,
2,
0,
1,
2,
0,
1,
0,
0,
1,
2,
0,
1,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
0,
0,
0,
0,
0
] |
[
"Comparison",
"of",
"Individual",
"Radiosensitivity",
"to",
"γ-Rays",
"and",
"Carbon",
"Ions",
"Carbon",
"ions",
"are",
"an",
"up-and-coming",
"ion",
"species,",
"currently",
"being",
"used",
"in",
"charged",
"particle",
"radiotherapy.",
"As",
"it",
"is",
"well",
"established",
"that",
"there",
"are",
"considerable",
"interindividual",
"differences",
"in",
"radiosensitivity",
"in",
"the",
"general",
"population",
"that",
"can",
"significantly",
"influence",
"clinical",
"outcomes",
"of",
"radiotherapy,",
"we",
"evaluate",
"the",
"degree",
"of",
"these",
"differences",
"in",
"the",
"context",
"of",
"carbon",
"ion",
"therapy",
"compared",
"with",
"conventional",
"radiotherapy.",
"In",
"this",
"study,",
"we",
"evaluate",
"individual",
"radiosensitivity",
"following",
"exposure",
"to",
"carbon-13",
"ions",
"or",
"γ-rays",
"in",
"peripheral",
"blood",
"lymphocytes",
"of",
"healthy",
"individuals",
"based",
"on",
"the",
"frequency",
"of",
"ionizing",
"radiation",
"(IR)-",
"induced",
"DNA",
"double",
"strand",
"breaks",
"(DSBs)",
"that",
"was",
"either",
"misrepaired",
"or",
"left",
"unrepaired",
"to",
"form",
"chromosomal",
"aberrations",
"(CAs)",
"(simply",
"referred",
"to",
"here",
"as",
"DSBs",
"for",
"brevity).",
"Levels",
"of",
"DSBs",
"were",
"estimated",
"from",
"the",
"scoring",
"of",
"CAs",
"visualized",
"with",
"telomere",
"/",
"centromere",
"-",
"fluorescence",
"in",
"situ",
"hybridization",
"(TC-FISH).",
"We",
"examine",
"radiosensitivity",
"at",
"the",
"dose",
"of",
"2",
"Gy,",
"a",
"routinely",
"administered",
"dose",
"during",
"fractionated",
"radiotherapy,",
"and",
"we",
"determined",
"that",
"a",
"wide",
"range",
"of",
"DSBs",
"were",
"induced",
"by",
"the",
"given",
"dose",
"among",
"healthy",
"individuals,",
"with",
"highly",
"radiosensitive",
"individuals",
"harboring",
"more",
"IR",
"-",
"induced",
"breaks",
"in",
"the",
"genome",
"than",
"radioresistant",
"individuals",
"following",
"exposure",
"to",
"the",
"same",
"dose.",
"Furthermore,",
"we",
"determined",
"the",
"relative",
"effectiveness",
"of",
"carbon",
"irradiation",
"in",
"comparison",
"to",
"γ-irradiation",
"in",
"the",
"induction",
"of",
"DSBs",
"at",
"each",
"studied",
"dose",
"(isodose",
"effect),",
"a",
"quality",
"we",
"term",
"\"",
"relative",
"dose",
"effect",
"\"",
"(RDE).",
"This",
"ratio",
"is",
"advantageous,",
"as",
"it",
"allows",
"for",
"simple",
"comparison",
"of",
"dose-response",
"curves.",
"At",
"2",
"Gy,",
"carbon",
"irradiation",
"was",
"three",
"times",
"more",
"effective",
"in",
"inducing",
"DSBs",
"compared",
"with",
"γ-irradiation",
"(RDE",
"of",
"3);",
"these",
"results",
"were",
"confirmed",
"using",
"a",
"second",
"cytogenetic",
"technique,",
"multicolor-FISH.",
"We",
"also",
"analyze",
"radiosensitivity",
"at",
"other",
"doses",
"(0.2-15",
"Gy),",
"to",
"represent",
"hypo",
"-",
"and",
"hyperfractionation",
"doses",
"and",
"determined",
"that",
"RDE",
"is",
"dose",
"dependent:",
"high",
"ratios",
"at",
"low",
"doses,",
"and",
"approaching",
"1",
"at",
"high",
"doses.",
"These",
"results",
"could",
"have",
"clinical",
"implications",
"as",
"IR-induced",
"DNA",
"damage",
"and",
"the",
"ensuing",
"CAs",
"and",
"genomic",
"instability",
"can",
"have",
"significant",
"cellular",
"consequences",
"that",
"could",
"potentially",
"have",
"profound",
"implications",
"for",
"long-term",
"human",
"health",
"after",
"IR",
"exposure,",
"such",
"as",
"the",
"emergence",
"of",
"secondary",
"cancers",
"and",
"other",
"pathobiological",
"conditions",
"after",
"radiotherapy."
] | [
1,
0,
1,
1,
0,
1,
0,
1,
2,
1,
2,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
1,
0,
0,
1,
2,
0,
0,
0,
0,
1,
2,
0,
1,
0,
0,
0,
1,
0,
0,
1,
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
1,
0,
1,
2,
1,
1,
0,
1,
0,
1,
2,
2,
0,
1,
1,
0,
0,
0,
1,
0,
1,
2,
1,
1,
1,
2,
2,
2,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
1,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
0,
1,
0,
1,
2,
2,
2,
1,
0,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
1,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
1,
0,
1,
1,
0,
0,
1,
1,
0,
0,
1,
0,
1,
1,
0,
0,
1,
0,
1,
1,
0,
1,
2,
0,
0,
1,
0,
0,
0,
0,
1,
2,
0,
1,
1,
0,
0,
0,
1,
0,
0,
1,
0,
1,
0,
0,
0,
1,
1,
1,
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
1,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
1,
0,
0,
0,
1,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
1,
2,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
1,
0,
1,
2,
2,
0,
0,
0,
1,
0,
1,
2,
0,
0,
1,
1,
1,
0,
0,
0,
0,
1,
1,
0,
1,
1,
2,
0,
1,
2,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
2,
0,
1
] |
[
"Dynamic",
"Contrast-enhanced",
"MR",
"Imaging",
"in",
"Renal",
"Cell",
"Carcinoma:",
"Reproducibility",
"of",
"Histogram",
"Analysis",
"on",
"Pharmacokinetic",
"Parameters",
"Pharmacokinetic",
"parameters",
"derived",
"from",
"dynamic",
"contrast-enhanced",
"magnetic",
"resonance",
"imaging",
"(DCE-MRI)",
"have",
"been",
"increasingly",
"used",
"to",
"evaluate",
"the",
"permeability",
"of",
"tumor",
"vessel.",
"Histogram",
"metrics",
"are",
"a",
"recognized",
"promising",
"method",
"of",
"quantitative",
"MR",
"imaging",
"that",
"has",
"been",
"recently",
"introduced",
"in",
"analysis",
"of",
"DCE-MRI",
"pharmacokinetic",
"parameters",
"in",
"oncology",
"due",
"to",
"tumor",
"heterogeneity.",
"In",
"this",
"study,",
"21",
"patients",
"with",
"renal",
"cell",
"carcinoma",
"(RCC)",
"underwent",
"paired",
"DCE-MRI",
"studies",
"on",
"a",
"3.0",
"T",
"MR",
"system.",
"Extended",
"Tofts",
"model",
"and",
"population-based",
"arterial",
"input",
"function",
"were",
"used",
"to",
"calculate",
"kinetic",
"parameters",
"of",
"RCC",
"tumors.",
"Mean",
"value",
"and",
"histogram",
"metrics",
"(Mode,",
"Skewness",
"and",
"Kurtosis)",
"of",
"each",
"pharmacokinetic",
"parameter",
"were",
"generated",
"automatically",
"using",
"ImageJ",
"software.",
"Intra-",
"and",
"inter-observer",
"reproducibility",
"and",
"scan-rescan",
"reproducibility",
"were",
"evaluated",
"using",
"intra-class",
"correlation",
"coefficients",
"(ICCs)",
"and",
"coefficient",
"of",
"variation",
"(CoV).",
"Our",
"results",
"demonstrated",
"that",
"the",
"histogram",
"method",
"(Mode,",
"Skewness",
"and",
"Kurtosis)",
"was",
"not",
"superior",
"to",
"the",
"conventional",
"Mean",
"value",
"method",
"in",
"reproducibility",
"evaluation",
"on",
"DCE-MRI",
"pharmacokinetic",
"parameters",
"(K(trans)",
"&Ve)",
"in",
"renal",
"cell",
"carcinoma,",
"especially",
"for",
"Skewness",
"and",
"Kurtosis",
"which",
"showed",
"lower",
"intra-,",
"inter-observer",
"and",
"scan-rescan",
"reproducibility",
"than",
"Mean",
"value.",
"Our",
"findings",
"suggest",
"that",
"additional",
"studies",
"are",
"necessary",
"before",
"wide",
"incorporation",
"of",
"histogram",
"metrics",
"in",
"quantitative",
"analysis",
"of",
"DCE-MRI",
"pharmacokinetic",
"parameters."
] | [
1,
2,
2,
2,
0,
1,
2,
2,
1,
0,
1,
0,
0,
1,
1,
1,
1,
0,
0,
1,
2,
2,
2,
2,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
1,
0,
1,
0,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
2,
2,
1,
0,
0,
1,
0,
0,
0,
0,
0,
1,
2,
0,
1,
2,
0,
1,
1,
1,
2,
0,
0,
0,
0,
1,
1,
0,
1,
1,
1,
2,
0,
1,
0,
1,
1,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
1,
2,
1,
0,
1,
2,
0,
0,
1,
0,
0,
0,
1,
2,
2,
1,
0,
1,
2,
2,
1,
0,
0,
0,
0,
0,
1,
0,
1,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
0,
1,
1,
1,
0,
0,
0,
1,
2,
2,
0,
0,
1,
2,
2,
0,
0,
0,
1,
1,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
1,
1,
1
] |
[
"Antidiabetic",
"potential",
"of",
"bioactive",
"molecules",
"coated",
"chitosan",
"nanoparticles",
"in",
"experimental",
"rats",
"The",
"present",
"study",
"was",
"carried",
"out",
"to",
"examine",
"the",
"antidiabetic",
"effects",
"of",
"chitosan",
"nanoparticles",
"(CNPs)",
"loaded",
"with",
"(Stevia",
"rebaudiana",
"leaf",
"extract",
"-",
"SRLE)",
"bioactive",
"molecules",
"in",
"a",
"rat",
"model",
"of",
"streptozotocin",
"(STZ)",
"induced",
"diabetes",
"mellitus.",
"Successful",
"crosslinking",
"of",
"the",
"bioactive",
"molecules",
"to",
"the",
"chitosan",
"nanoparticles",
"was",
"confirmed",
"by",
"Fourier",
"Transform",
"Infrared",
"Spectroscopy",
"(FTIR).",
"The",
"colloidal",
"characteristics",
"of",
"the",
"synthesized",
"nanoparticles",
"were",
"revealed",
"by",
"X-ray",
"Diffraction",
"(XRD)",
"analysis.",
"Morphological",
"analysis",
"by",
"Transmission",
"Electron",
"Microscopy",
"(TEM)",
"revealed",
"that",
"the",
"bioactive",
"molecule",
"-loaded",
"CNPs",
"were",
"well-dispersed",
"and",
"spherical",
"or",
"polygonal",
"in",
"shape",
"with",
"an",
"average",
"size",
"of<73.27nm",
"than",
"the",
"z-average",
"value",
"(327nm)",
"as",
"measured",
"by",
"Dynamic",
"Light",
"Scattering",
"(DLS).",
"SRLE",
"CNP",
"-",
"treated",
"diabetic",
"rats",
"showed",
"a",
"significant",
"reduction",
"in",
"their",
"mean",
"fasting",
"blood",
"glucose",
"level",
"compared",
"with",
"the",
"diabetic",
"control",
"group.",
"The",
"serum",
"levels",
"of",
"various",
"enzymes",
"viz.,",
"serum",
"glutamic",
"oxaloacetic",
"transaminase",
"(SGOT),",
"serum",
"glutamic",
"pyruvic",
"transaminase",
"(SGPT),",
"alkaline",
"phosphatases",
"(ALP),",
"lipid",
"peroxidation,",
"and",
"antioxidant",
"such",
"as",
"catalase",
"(CAT),",
"reduced",
"glutathione",
"(GSH),",
"and",
"superoxide",
"dismutase",
"(SOD)",
"in",
"the",
"SRLE",
"CNP",
"-",
"treated",
"group",
"were",
"closer",
"to",
"normal",
"levels",
"than",
"those",
"in",
"the",
"diabetic",
"control",
"group."
] | [
1,
1,
0,
1,
2,
0,
1,
2,
0,
1,
1,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
1,
2,
1,
2,
1,
0,
0,
1,
2,
2,
2,
0,
1,
1,
2,
0,
0,
1,
1,
0,
1,
1,
1,
1,
2,
0,
1,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
1,
2,
2,
2,
1,
0,
1,
2,
0,
0,
1,
1,
0,
0,
0,
1,
2,
2,
2,
1,
1,
0,
1,
2,
2,
1,
0,
0,
0,
1,
2,
0,
1,
0,
1,
0,
1,
0,
1,
0,
1,
0,
0,
1,
2,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
2,
2,
1,
1,
1,
0,
1,
1,
1,
0,
0,
1,
1,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
1,
1,
2,
0,
1,
1,
0,
0,
1,
0,
1,
2,
2,
2,
1,
1,
2,
2,
2,
1,
1,
2,
1,
1,
2,
0,
1,
0,
0,
1,
1,
1,
2,
1,
0,
1,
2,
1,
0,
0,
1,
1,
0,
1,
1,
0,
0,
0,
1,
1,
0,
0,
0,
0,
1,
1,
2
] |
[
"Monosubstituted",
"Benzene",
"Derivatives",
"from",
"Fruits",
"of",
"Ficus",
"hirta",
"and",
"Their",
"Antifungal",
"Activity",
"against",
"Phytopathogen",
"Penicillium",
"italicum",
"Ficus",
"hirta,",
"a",
"widely",
"consumed",
"food",
"by",
"Hakka",
"people,",
"has",
"been",
"reported",
"to",
"show",
"potent",
"antifungal",
"activity",
"against",
"phytopathogen",
"Penicillium",
"italicum.",
"However,",
"there",
"is",
"no",
"report",
"of",
"chemical",
"constituents",
"responsible",
"for",
"the",
"antifungal",
"activity.",
"In",
"the",
"current",
"study,",
"nine",
"monosubstituted",
"benzene",
"derivatives,",
"including",
"three",
"new",
"derivatives",
"(1-3),",
"were",
"isolated",
"from",
"the",
"fruits",
"of",
"F.",
"hirta.",
"The",
"structures",
"of",
"these",
"isolates",
"were",
"elucidated",
"on",
"the",
"basis",
"of",
"the",
"analysis",
"of",
"spectroscopic",
"data",
"(mass",
"spectrometry",
"and",
"nuclear",
"magnetic",
"resonance).",
"All",
"of",
"the",
"isolates",
"were",
"evaluated",
"for",
"antifungal",
"activities",
"against",
"P.",
"italicum.",
"At",
"an",
"equivalent",
"concentration,",
"compound",
"1",
"exhibited",
"stronger",
"antifungal",
"activity",
"than",
"that",
"of",
"the",
"ethanol",
"extract",
"of",
"F.",
"hirta",
"fruits."
] | [
1,
2,
2,
0,
1,
0,
1,
2,
0,
0,
1,
2,
1,
1,
1,
2,
1,
2,
0,
0,
0,
1,
0,
1,
1,
0,
0,
1,
0,
0,
0,
1,
2,
1,
1,
1,
2,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
1,
2,
0,
0,
0,
1,
0,
1,
2,
2,
0,
0,
0,
1,
0,
0,
1,
0,
0,
1,
0,
1,
2,
0,
1,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
1,
1,
2,
0,
1,
2,
2,
0,
0,
0,
1,
0,
1,
0,
1,
2,
1,
1,
2,
0,
0,
1,
1,
1,
0,
0,
1,
1,
2,
0,
0,
0,
0,
1,
1,
0,
1,
2,
1
] |
[
"Effects",
"of",
"analgesics",
"and",
"antidepressants",
"on",
"TREK-2",
"and",
"TRESK",
"currents",
"TWIK-related",
"K(+)",
"channel-2",
"(TREK-2)",
"and",
"TWIK-related",
"spinal",
"cord",
"K(+)",
"(TRESK)",
"channel",
"are",
"members",
"of",
"two-pore",
"domain",
"K(+)",
"channel",
"family.",
"They",
"are",
"well",
"expressed",
"and",
"help",
"to",
"set",
"the",
"resting",
"membrane",
"potential",
"in",
"sensory",
"neurons.",
"Modulation",
"of",
"TREK-2",
"and",
"TRESK",
"channels",
"are",
"involved",
"in",
"the",
"pathogenesis",
"of",
"pain,",
"and",
"specifi",
"c",
"activators",
"of",
"TREK-2",
"and",
"TRESK",
"may",
"be",
"benefi",
"cial",
"for",
"the",
"treatment",
"of",
"pain",
"symptoms.",
"However,",
"the",
"effect",
"of",
"commonly",
"used",
"analgesics",
"on",
"TREK-2",
"and",
"TRESK",
"channels",
"are",
"not",
"known.",
"Here,",
"we",
"investigated",
"the",
"effect",
"of",
"analgesics",
"on",
"TREK-2",
"and",
"TRESK",
"channels.",
"The",
"effects",
"of",
"analgesics",
"were",
"examined",
"in",
"HEK",
"cells",
"transfected",
"with",
"TREK-2",
"or",
"TRESK.",
"Amitriptyline,",
"citalopram,",
"escitalopram,",
"and",
"fluoxetine",
"significantly",
"inhibited",
"TREK-2",
"and",
"TRESK",
"currents",
"in",
"HEK",
"cells",
"(p<0.05,",
"n=10).",
"Acetaminophen,",
"ibuprofen,",
"nabumetone,",
"and",
"bupropion",
"inhibited",
"TRESK,",
"but",
"had",
"no",
"effect",
"on",
"TREK-2.",
"These",
"results",
"show",
"that",
"all",
"analgesics",
"tested",
"in",
"this",
"study",
"inhibit",
"TRESK",
"activity.",
"Further",
"study",
"is",
"needed",
"to",
"identify",
"the",
"mechanisms",
"by",
"which",
"the",
"analgesics",
"modulate",
"TREK-2",
"and",
"TRESK",
"differently."
] | [
1,
2,
1,
0,
1,
0,
1,
0,
1,
1,
1,
2,
2,
1,
0,
1,
2,
2,
2,
2,
2,
0,
0,
0,
1,
2,
2,
2,
2,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
2,
1,
0,
1,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
0,
2,
0,
1,
0,
1,
0,
1,
0,
0,
1,
2,
0,
0,
1,
0,
1,
1,
0,
0,
1,
2,
0,
0,
1,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
1,
2,
1,
0,
1,
0,
1,
1,
0,
1,
2,
1,
0,
0,
0,
1,
2,
1,
0,
1,
0,
1,
1,
1,
1,
0,
1,
1,
1,
1,
0,
1,
1,
0,
1,
2,
0,
0,
1,
1,
1,
0,
1,
0,
1,
0,
0,
1,
2,
0,
1,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
1,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
1,
0
] |
[
"Establishment",
"of",
"a",
"mouse",
"model",
"of",
"70%",
"lethal",
"dose",
"by",
"total-body",
"irradiation",
"Whereas",
"increasing",
"concerns",
"about",
"radiation",
"exposure",
"to",
"nuclear",
"disasters",
"or",
"side",
"effects",
"of",
"anticancer",
"radiotherapy,",
"relatively",
"little",
"research",
"for",
"radiation",
"damages",
"or",
"remedy",
"has",
"been",
"done.",
"The",
"purpose",
"of",
"this",
"study",
"was",
"to",
"establish",
"level",
"of",
"LD",
"70/30",
"(a",
"lethal",
"dose",
"for",
"70%",
"of",
"mice",
"within",
"30",
"days)",
"by",
"total-body",
"γ",
"irradiation",
"(TBI)",
"in",
"a",
"mouse",
"model.",
"For",
"this",
"purpose,",
"at",
"first,",
"8-",
"week-old",
"male",
"ICR",
"and",
"C57BL/6N",
"mice",
"from",
"A",
"and",
"B",
"companies",
"were",
"received",
"high",
"dose",
"(10,",
"11,",
"12",
"Gy)",
"TBI.",
"After",
"irradiation,",
"the",
"body",
"weight",
"and",
"survival",
"rate",
"were",
"monitored",
"for",
"30",
"days",
"consecutively.",
"In",
"next",
"experiment,",
"5-",
"week-old",
"male",
"ICR",
"and",
"C57BL/6N",
"mice",
"from",
"B",
"company",
"were",
"received",
"same",
"dose",
"irradiation.",
"Results",
"showed",
"that",
"survival",
"rate",
"and",
"body",
"weight",
"change",
"rate",
"in",
"inbred",
"C57BL/6N",
"mice",
"were",
"similar",
"between",
"A",
"and",
"B",
"company.",
"In",
"ICR",
"mice,",
"however,",
"survival",
"rate",
"and",
"body",
"weight",
"change",
"rate",
"were",
"completely",
"different",
"among",
"the",
"companies.",
"Significant",
"difference",
"of",
"survival",
"rate",
"both",
"ICR",
"and",
"C57BL6N",
"mice",
"was",
"not",
"observed",
"in",
"between",
"5-",
"week-old",
"and",
"8-",
"week-old",
"groups",
"receiving",
"10",
"or",
"12",
"Gy",
"TBI.",
"Our",
"results",
"indicate",
"that",
"the",
"strain",
"and",
"age",
"of",
"mice,",
"and",
"even",
"purchasing",
"company",
"(especially",
"outbred),",
"should",
"be",
"matched",
"over",
"experimental",
"groups",
"in",
"TBI",
"experiment.",
"Based",
"on",
"our",
"results,",
"8-",
"week-old",
"male",
"ICR",
"mice",
"from",
"B",
"company",
"subjected",
"to",
"12",
"Gy",
"of",
"TBI",
"showed",
"LD",
"70/30",
"and",
"suitable",
"as",
"a",
"mouse",
"model",
"for",
"further",
"development",
"of",
"new",
"drug",
"using",
"the",
"ideal",
"total-body",
"irradiation",
"model."
] | [
0,
0,
0,
1,
2,
0,
0,
1,
2,
0,
1,
2,
0,
0,
0,
0,
1,
2,
0,
1,
2,
0,
1,
2,
0,
1,
1,
0,
0,
1,
0,
1,
2,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
1,
2,
0,
0,
0,
1,
0,
0,
1,
0,
1,
2,
2,
1,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
1,
1,
0,
1,
2,
0,
1,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
1,
1,
0,
1,
0,
1,
2,
0,
1,
2,
0,
1,
0,
0,
1,
1,
0,
0,
1,
0,
1,
1,
1,
0,
1,
2,
0,
1,
2,
0,
0,
1,
1,
1,
1,
0,
0,
1,
2,
0,
1,
2,
2,
1,
0,
1,
2,
2,
0,
1,
0,
1,
0,
1,
2,
0,
1,
2,
0,
1,
2,
0,
1,
2,
2,
1,
0,
1,
2,
0,
0,
1,
1,
2,
0,
1,
2,
0,
1,
0,
1,
2,
0,
1,
1,
0,
0,
0,
1,
0,
0,
1,
1,
0,
0,
0,
0,
1,
1,
0,
1,
0,
0,
0,
1,
0,
1,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
1,
2,
0,
1,
1,
0,
0,
0,
1,
0,
1,
1,
1,
0,
0,
1,
2,
0,
0,
0,
1,
0,
1,
0,
1,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
1,
0,
0,
1,
1,
2,
1
] |
[
"Phytochemical",
"screening,",
"antiglycation",
"and",
"antioxidant",
"activities",
"of",
"whole",
"plant",
"of",
"Boerhavia",
"repens",
"L.",
"from",
"Cholistan,",
"Pakistan",
"Present",
"study",
"was",
"aimed",
"to",
"explore",
"a",
"traditionally",
"used",
"indigenous",
"medicinal",
"plant",
"Boerhavia",
"repens",
"(Nyctaginaceae",
"family)",
"of",
"the",
"Cholistan",
"desert,",
"Pakistan.",
"Crude",
"aqueous",
"and",
"methanolic",
"extracts",
"of",
"the",
"whole",
"plant",
"were",
"investigated",
"in",
"vitro",
"for",
"preliminary",
"phytochemical",
"screening,",
"antioxidant",
"and",
"antiglycation",
"activities.",
"Antioxidant",
"activities",
"were",
"determined",
"by",
"total",
"phenolic",
"contents,",
"1,1-diphenyl-2-picrylhydrazyl",
"(DPPH)",
"free",
"radical",
"scavenging",
"and",
"inhibition",
"of",
"lipid",
"peroxidation.",
"For",
"antiglycation",
"activities",
"browning",
"production",
"was",
"noted",
"and",
"thiobarbituric",
"acid",
"(TBA)",
"technique",
"was",
"used",
"to",
"determine",
"glycation",
"level.",
"Boerhavia",
"repens",
"expressed",
"considerable",
"amounts",
"of",
"phytochemicals.",
"Extract",
"yield",
"was",
"found",
"to",
"be",
"4.59%-7.85%",
"g/100g",
"of",
"dry",
"matter",
"with",
"total",
"phenolics",
"ranging",
"from",
"47.9-",
"190.77mg/GAE",
"per",
"g",
"for",
"aqueous",
"and",
"methanol",
"extract",
"respectively.",
"Strong",
"inhibitory",
"effect",
"was",
"exhibited",
"by",
"methanolic",
"extract",
"in",
"linoleic",
"acid",
"per",
"oxidation",
"system",
"(86.11%,",
"EC50=0.99mg/mL)",
"and",
"DPPH",
"assay",
"(88.65%,",
"EC50=212.33μg/ml).",
"In",
"term",
"of",
"browning",
"maximum",
"inhibition",
"(81.50%)",
"was",
"exhibited",
"by",
"methanolic",
"extract",
"at",
"37°C",
"at",
"third",
"week",
"of",
"incubation.",
"Both",
"extracts",
"expressed",
"significant",
"(P>0.05)",
"and",
"comparable",
"inhibition",
"of",
"glycation",
"level.",
"In",
"conclusion,",
"Boerhavia",
"repens",
"showed",
"promising",
"antioxidant",
"and",
"antiglycation",
"activities",
"validating",
"its",
"therapeutic",
"potential."
] | [
1,
1,
1,
0,
1,
2,
0,
1,
2,
0,
1,
2,
2,
0,
1,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
1,
2,
1,
2,
1,
1,
0,
0,
1,
2,
1,
1,
2,
0,
1,
2,
0,
0,
1,
2,
0,
1,
1,
2,
0,
0,
1,
1,
1,
0,
1,
2,
1,
2,
0,
0,
0,
0,
1,
0,
1,
1,
2,
2,
1,
0,
1,
0,
1,
1,
0,
1,
2,
1,
0,
0,
0,
0,
1,
2,
1,
1,
0,
0,
0,
0,
1,
2,
1,
2,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
1,
1,
0,
0,
0,
1,
2,
0,
1,
2,
1,
2,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
0,
1,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
1,
2,
0,
0,
1,
0,
1,
2,
0,
0,
1,
1
] |
[
"In",
"vitro",
"genotoxicity",
"of",
"pyridine",
"in",
"human",
"lymphocytes",
"This",
"work",
"was",
"carried",
"out",
"to",
"study",
"the",
"genotoxicity",
"of",
"pyridine",
"in",
"vitro",
"on",
"human",
"leucocyte",
"culture.",
"Cyclophosphamide,",
"a",
"well-known",
"carcinogen",
"was",
"used",
"as",
"positive",
"control.",
"The",
"four",
"different",
"concentrations",
"of",
"pyridine",
"and",
"cyclophosphamide",
"showed",
"breaks",
"and",
"pulverization",
"of",
"chromosomes",
"in",
"dose",
"dependent",
"manner.",
"Higher",
"number",
"of",
"pulverization",
"was",
"observed",
"with",
"higher",
"concentration",
"of",
"pyridine",
"(3.25μg/mL).",
"Based",
"on",
"this",
"data,",
"our",
"results",
"confirm",
"that",
"both",
"pyridine",
"and",
"its",
"precursor",
"showed",
"genotoxicity",
"against",
"human",
"lymphocytes."
] | [
1,
2,
1,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
2,
0,
1,
1,
1,
1,
0,
0,
1,
0,
0,
0,
1,
2,
0,
0,
0,
1,
0,
1,
0,
1,
0,
1,
0,
1,
2,
2,
0,
1,
2,
0,
1,
2,
0,
1,
0,
0,
0,
1,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
0,
1,
0,
1,
0,
1,
1
] |
[
"Alzheimer's",
"disease",
"against",
"peptides",
"products",
"of",
"enzymatic",
"cleavage",
"of",
"APP",
"protein.",
"Forming",
"and",
"variety",
"of",
"fibrillating",
"peptides",
"-",
"some",
"aspects",
"Various",
"and",
"different",
"peptides",
"products",
"resulting",
"from",
"enzymatic",
"protein",
"cleavage",
"of",
"Amyloid",
"Precursor",
"Proteins",
"(APP)",
"are",
"the",
"main",
"agents",
"in",
"the",
"pathophysiology",
"of",
"Alzheimer's",
"disease",
"(AD).",
"Although",
"relatively",
"well-known,",
"they",
"still",
"arouse",
"interest",
"leading",
"to",
"further",
"intense",
"and",
"wide-ranging",
"research.",
"Their",
"biology",
"and",
"physico-chemical",
"properties",
"still",
"are",
"challenging",
"for",
"basic,",
"experimental",
"research",
"and",
"are",
"matter",
"of",
"scientific",
"debate.",
"The",
"APP",
"itself",
"and",
"its",
"functions",
"are",
"still",
"somewhat",
"enigmatic",
"and",
"therefore",
"it",
"is",
"also",
"called",
"the",
"All",
"Purpose",
"Protein.",
"Apart",
"from",
"well",
"known",
"amyloidogenic",
"and",
"antiamyloidogenic",
"(non-amyloidogenic)",
"enzymatic",
"cleavage",
"pathways",
"of",
"APP",
"protein",
"this",
"paper",
"deals",
"with",
"issues",
"connected",
"with",
"other,",
"alternative",
"pathways",
"that",
"seem",
"to",
"be",
"interesting",
"and",
"important",
"as",
"well.",
"They",
"lead",
"to",
"other",
"than",
"Aβ",
"forms",
"of",
"peptide",
"products",
"such",
"as:",
"N-APP,",
"N-terminally",
"cleavage",
"products",
"of",
"APP",
"(N-terminally",
"truncated)",
"Aβ',",
"γ-",
"secretase",
"-independent",
"pathway",
"products",
"that",
"involve",
"concerted",
"cleavages",
"of",
"APP",
"by",
"α-",
"and",
"β-secretase",
"or",
"products",
"that",
"emerge",
"after",
"caspase",
"activity.",
"Presence",
"of",
"all",
"these",
"peptides",
"in",
"CSF,",
"ISF,",
"blood",
"serum",
"and",
"urine",
"of",
"the",
"AD",
"patients",
"is",
"crucial",
"for",
"successful",
"diagnosis,",
"giving",
"rise",
"to",
"hope",
"of",
"their",
"better",
"detection",
"and",
"potentially",
"better",
"treatment",
"of",
"AD.",
"Therefore,",
"newly",
"discovered",
"products",
"of",
"the",
"AβT",
"domain",
"cleavage",
"(Aβ",
"total",
"i.e.",
"full",
"fibrillating",
"domain",
"of",
"APP),",
"Aβ",
"type",
"products",
"and",
"other",
"peptides",
"because",
"of",
"their",
"biology",
"and",
"physico-chemical",
"properties",
"are",
"very",
"intriguing",
"and",
"deserve",
"further",
"experimental",
"research.",
"On",
"the",
"other",
"hand",
"after",
"better",
"recognition",
"and",
"better",
"understanding",
"their",
"biology",
"they",
"might",
"be",
"enormously",
"useful",
"in",
"the",
"future",
"for",
"diagnosis",
"and",
"therapy",
"for",
"example",
"Alzheimer's",
"disease."
] | [
1,
2,
0,
1,
2,
0,
1,
1,
0,
1,
2,
1,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
1,
2,
0,
1,
2,
2,
1,
0,
0,
0,
1,
0,
0,
1,
0,
1,
2,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
2,
0,
1,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
1,
2,
2,
2,
2,
0,
1,
2,
0,
1,
0,
0,
1,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
0,
0,
1,
0,
0,
0,
0,
1,
1,
2,
1,
1,
2,
2,
2,
2,
0,
0,
0,
1,
0,
1,
0,
1,
0,
1,
0,
1,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
0,
1,
1,
1,
2,
0,
1,
0,
0,
1,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
0,
1,
0,
0,
1,
2,
2,
1,
2,
0,
0,
1,
2,
2,
2,
1,
2,
2,
0,
0,
1,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
1,
2
] |
[
"Clinical",
"Significance",
"of",
"2",
"Deep",
"Posterior",
"Perianal",
"Spaces",
"to",
"Complex",
"Cryptoglandular",
"Fistulas",
"Confusion",
"exists",
"regarding",
"the",
"clinical",
"significance",
"of",
"the",
"deep",
"posterior",
"intersphincteric",
"space",
"and",
"deep",
"postanal",
"space",
"to",
"complex",
"perianal",
"fistulas.",
"The",
"purpose",
"of",
"this",
"study",
"was",
"to",
"assess",
"the",
"clinical",
"significance",
"of",
"the",
"2",
"deep",
"posterior",
"perianal",
"spaces",
"and",
"to",
"describe",
"in",
"detail",
"the",
"courses",
"of",
"posterior",
"complex",
"cryptoglandular",
"fistula",
"extensions.",
"This",
"was",
"a",
"retrospective",
"study.",
"MRI",
"-",
"based",
"characteristics",
"of",
"selected",
"perianal",
"fistulas",
"were",
"independently",
"evaluated",
"by",
"examiners",
"who",
"focused",
"on",
"lesions",
"in",
"these",
"2",
"spaces",
"and",
"were",
"blinded",
"to",
"each",
"other's",
"findings.",
"This",
"study",
"was",
"conducted",
"in",
"the",
"colorectal",
"surgery",
"and",
"radiology",
"departments",
"of",
"a",
"large",
"university",
"teaching",
"hospital",
"in",
"China.",
"Included",
"in",
"the",
"study",
"were",
"patients",
"who",
"underwent",
"pelvic",
"MRI",
"for",
"posterior",
"perianal",
"fistula",
"between",
"October",
"2012",
"and",
"December",
"2014.",
"The",
"occurrence",
"rates",
"of",
"these",
"2",
"deep",
"perianal",
"space",
"lesions",
"in",
"posterior",
"cryptoglandular",
"fistulas",
"were",
"determined.",
"A",
"total",
"of",
"513",
"primary",
"posterior",
"cryptoglandular",
"fistulas",
"were",
"identified",
"in",
"508",
"patients,",
"including",
"167",
"deep",
"posterior",
"intersphincteric",
"space",
"lesions",
"(32.6%)",
"and",
"23",
"deep",
"postanal",
"space",
"lesions",
"(4.5%).",
"Of",
"those,",
"173",
"fistulas",
"(33.7%)",
"were",
"evaluated",
"as",
"complex.",
"The",
"former",
"and",
"latter",
"spaces",
"were",
"involved",
"in",
"79.2%",
"(137/173)",
"and",
"13.3%",
"(23/173)",
"of",
"posterior",
"complex",
"fistulas.",
"Compared",
"with",
"deep",
"postanal",
"space",
"lesions,",
"deep",
"posterior",
"intersphincteric",
"space",
"lesions",
"were",
"more",
"common",
"in",
"cases",
"with",
"high",
"transsphincteric",
"or",
"suprasphincteric",
"fistulas",
"(80.1%",
"vs",
"15.8%),",
"synchronous",
"multiple",
"transsphincteric",
"fistulas",
"(82.4%",
"vs",
"20.6%),",
"horseshoe-like",
"fistulas",
"(85.5%",
"vs",
"14.5%),",
"and",
"supralevator",
"fistulas",
"(93.5%",
"vs",
"16.1%).",
"Similar",
"incidences",
"were",
"also",
"seen",
"in",
"cases",
"with",
"ischioanal",
"-",
"involved",
"horseshoe-like",
"fistulas",
"(75.0%",
"vs",
"25.0%).",
"This",
"study",
"was",
"limited",
"by",
"its",
"retrospective",
"nature.",
"The",
"deep",
"posterior",
"intersphincteric",
"space",
"is",
"more",
"likely",
"than",
"the",
"deep",
"postanal",
"space",
"to",
"be",
"involved",
"in",
"complex",
"cryptoglandular",
"fistulas",
"and",
"is",
"likely",
"to",
"play",
"a",
"more",
"important",
"role",
"in",
"the",
"management",
"of",
"complex",
"cryptoglandular",
"fistulas."
] | [
1,
2,
0,
0,
1,
2,
2,
2,
0,
1,
1,
1,
0,
0,
0,
0,
1,
2,
0,
0,
1,
2,
1,
2,
0,
1,
2,
2,
0,
1,
1,
2,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
1,
1,
1,
0,
0,
0,
1,
2,
1,
0,
1,
1,
0,
1,
1,
2,
0,
0,
1,
0,
1,
0,
1,
0,
1,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
2,
0,
1,
2,
0,
0,
0,
1,
2,
2,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
0,
1,
1,
2,
0,
1,
0,
0,
1,
0,
0,
1,
1,
0,
0,
0,
1,
2,
2,
1,
0,
1,
1,
1,
0,
1,
0,
0,
0,
0,
1,
1,
1,
1,
0,
1,
0,
0,
1,
0,
0,
1,
2,
1,
2,
1,
0,
0,
0,
1,
2,
2,
1,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
0,
1,
0,
1,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
1,
1,
1,
0,
1,
2,
2,
1,
1,
2,
1,
2,
1,
0,
0,
1,
0,
1,
0,
1,
1,
0,
1,
2,
0,
0,
0,
1,
1,
1,
2,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
1,
0,
1,
1,
2,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
1,
2,
1,
2,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
0,
1,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
1,
1
] |
[
"Conditional",
"ablation",
"of",
"myeloid",
"TNF",
"increases",
"lesion",
"volume",
"after",
"experimental",
"stroke",
"in",
"mice,",
"possibly",
"via",
"altered",
"ERK1/2",
"signaling",
"Microglia",
"are",
"activated",
"following",
"cerebral",
"ischemia",
"and",
"increase",
"their",
"production",
"of",
"the",
"neuro",
"-",
"and",
"immunomodulatory",
"cytokine",
"tumor",
"necrosis",
"factor",
"(TNF).",
"To",
"address",
"the",
"function",
"of",
"TNF",
"from",
"this",
"cellular",
"source",
"in",
"focal",
"cerebral",
"ischemia",
"we",
"used",
"TNF",
"conditional",
"knock",
"out",
"mice",
"(LysMcreTNF(fl/fl))",
"in",
"which",
"the",
"TNF",
"gene",
"was",
"deleted",
"in",
"cells",
"of",
"the",
"myeloid",
"lineage,",
"including",
"microglia.",
"The",
"deletion",
"reduced",
"secreted",
"TNF",
"levels",
"in",
"lipopolysaccharide",
"-stimulated",
"cultured",
"primary",
"microglia",
"by",
"~93%.",
"Furthermore,",
"phosphorylated-ERK",
"/",
"ERK",
"ratios",
"were",
"significantly",
"decreased",
"in",
"naïve",
"LysMcreTNF(fl/fl)",
"mice",
"demonstrating",
"altered",
"ERK",
"signal",
"transduction.",
"Micro-PET",
"using",
"(18)[F]-fluorodeoxyglucose",
"immediately",
"after",
"focal",
"cerebral",
"ischemia",
"showed",
"increased",
"glucose",
"uptake",
"in",
"LysMcreTNF(fl/fl)",
"mice,",
"representing",
"significant",
"metabolic",
"changes,",
"that",
"translated",
"into",
"increased",
"infarct",
"volumes",
"at",
"24",
"hours",
"and",
"5",
"days",
"compared",
"to",
"littermates",
"(TNFfl/fl).",
"In",
"naïve",
"LysMcreTNF(fl/fl)",
"mice",
"cytokine",
"levels",
"were",
"low",
"and",
"comparable",
"to",
"littermates.",
"At",
"6",
"hours,",
"TNF",
"producing",
"microglia",
"were",
"reduced",
"by",
"56%",
"in",
"the",
"ischemic",
"cortex",
"in",
"LysMcreTNF(fl/fl)",
"mice",
"compared",
"to",
"littermate",
"mice,",
"whereas",
"no",
"TNF(+)",
"leukocytes",
"were",
"detected.",
"At",
"24",
"hours,",
"pro-inflammatory",
"cytokine",
"(TNF,",
"IL-1β,",
"IL-6,",
"IL-5",
"and",
"CXCL1)",
"levels",
"were",
"significantly",
"lower",
"in",
"LysMcreTNF(fl/fl)",
"mice,",
"despite",
"comparable",
"infiltrating",
"leukocyte",
"populations.",
"Our",
"results",
"identify",
"microglia",
"l",
"TNF",
"as",
"beneficial",
"and",
"neuroprotective",
"in",
"the",
"acute",
"phase",
"and",
"as",
"a",
"modulator",
"of",
"neuroinflammation",
"at",
"later",
"time",
"points",
"after",
"experimental",
"ischemia,",
"which",
"may",
"contribute",
"to",
"regenerative",
"recovery."
] | [
0,
1,
0,
1,
1,
0,
1,
1,
0,
1,
2,
2,
2,
0,
0,
0,
1,
2,
1,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
1,
1,
2,
2,
1,
0,
0,
0,
1,
0,
1,
0,
0,
1,
2,
0,
1,
2,
2,
0,
0,
1,
0,
1,
2,
2,
2,
0,
0,
0,
1,
2,
0,
1,
0,
1,
0,
0,
1,
2,
0,
1,
0,
1,
0,
0,
1,
1,
0,
1,
0,
1,
2,
2,
0,
0,
0,
1,
0,
1,
1,
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
1,
2,
1,
0,
1,
0,
0,
1,
2,
2,
0,
0,
1,
2,
0,
1,
2,
0,
0,
1,
1,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
0,
1,
2,
2,
1,
1,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
0,
1,
2,
0,
0,
1,
2,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
2,
1,
1,
1,
1,
0,
1,
1,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
2,
0,
0,
0,
1,
0,
1,
0,
0,
0,
1,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
2
] |
[
"Screening",
"of",
"Conditionally",
"Reprogrammed",
"Patient",
"-Derived",
"Carcinoma",
"Cells",
"Identifies",
"ERCC3",
"-",
"MYC",
"Interactions",
"as",
"a",
"Target",
"in",
"Pancreatic",
"Cancer",
"Even",
"when",
"diagnosed",
"prior",
"to",
"metastasis,",
"pancreatic",
"ductal",
"adenocarcinoma",
"(PDAC)",
"is",
"a",
"devastating",
"malignancy",
"with",
"almost",
"90%",
"lethality,",
"emphasizing",
"the",
"need",
"for",
"new",
"therapies",
"optimally",
"targeting",
"the",
"tumors",
"of",
"individual",
"patients.",
"We",
"first",
"developed",
"a",
"panel",
"of",
"new",
"physiologic",
"models",
"for",
"study",
"of",
"PDAC,",
"expanding",
"surgical",
"PDAC",
"tumor",
"samples",
"in",
"culture",
"using",
"short-term",
"culture",
"and",
"conditional",
"reprogramming",
"with",
"the",
"Rho",
"kinase",
"inhibitor",
"Y-27632,",
"and",
"creating",
"matched",
"patient-derived",
"xenografts",
"(PDX).",
"These",
"were",
"evaluated",
"for",
"sensitivity",
"to",
"a",
"large",
"panel",
"of",
"clinical",
"agents,",
"and",
"promising",
"leads",
"further",
"evaluated",
"mechanistically.",
"Only",
"a",
"small",
"minority",
"of",
"tested",
"agents",
"was",
"cytotoxic",
"in",
"minimally",
"passaged",
"PDAC",
"cultures",
"in",
"vitro",
"Drugs",
"interfering",
"with",
"protein",
"turnover",
"and",
"transcription",
"were",
"among",
"most",
"cytotoxic.",
"Among",
"transcriptional",
"repressors,",
"triptolide,",
"a",
"covalent",
"inhibitor",
"of",
"ERCC3,",
"was",
"most",
"consistently",
"effective",
"in",
"vitro",
"and",
"in",
"vivo",
"causing",
"prolonged",
"complete",
"regression",
"in",
"multiple",
"PDX",
"models",
"resistant",
"to",
"standard",
"PDAC",
"therapies.",
"Importantly,",
"triptolide",
"showed",
"superior",
"activity",
"in",
"MYC-amplified",
"PDX",
"models",
"and",
"elicited",
"rapid",
"and",
"profound",
"depletion",
"of",
"the",
"oncoprotein",
"MYC,",
"a",
"transcriptional",
"regulator.",
"Expression",
"of",
"ERCC3",
"and",
"MYC",
"was",
"interdependent",
"in",
"PDACs,",
"and",
"acquired",
"resistance",
"to",
"triptolide",
"depended",
"on",
"elevated",
"ERCC3",
"and",
"MYC",
"expression.",
"The",
"Cancer",
"Genome",
"Atlas",
"analysis",
"indicates",
"ERCC3",
"expression",
"predicts",
"poor",
"prognosis,",
"particularly",
"in",
"CDKN2A-null,",
"highly",
"proliferative",
"tumors.",
"This",
"provides",
"initial",
"preclinical",
"evidence",
"for",
"an",
"essential",
"role",
"of",
"MYC",
"-",
"ERCC3",
"interactions",
"in",
"PDAC,",
"and",
"suggests",
"a",
"new",
"mechanistic",
"approach",
"for",
"disruption",
"of",
"critical",
"survival",
"signaling",
"in",
"MYC",
"-dependent",
"cancers.",
"Clin",
"Cancer",
"Res;",
"22(24);",
"6153-63.",
"©2016",
"AACR."
] | [
1,
0,
1,
2,
1,
0,
1,
2,
0,
1,
0,
1,
1,
0,
0,
1,
0,
1,
2,
0,
0,
1,
0,
0,
1,
1,
2,
2,
1,
0,
0,
1,
2,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
1,
1,
0,
1,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
1,
1,
0,
1,
0,
1,
0,
1,
1,
1,
2,
0,
1,
0,
1,
1,
0,
1,
2,
0,
0,
1,
2,
1,
1,
0,
0,
0,
1,
2,
1,
0,
0,
1,
0,
1,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
2,
0,
1,
0,
0,
0,
1,
1,
1,
2,
1,
0,
0,
1,
2,
0,
1,
0,
0,
0,
1,
0,
1,
2,
1,
0,
1,
2,
0,
1,
0,
0,
1,
1,
1,
2,
0,
1,
2,
0,
1,
2,
2,
0,
1,
1,
1,
1,
0,
1,
1,
1,
0,
1,
0,
1,
2,
0,
1,
1,
1,
0,
0,
1,
0,
0,
1,
0,
0,
1,
2,
0,
1,
2,
1,
0,
1,
0,
1,
0,
0,
0,
1,
0,
1,
2,
0,
1,
0,
0,
0,
1,
0,
1,
1,
1,
2,
2,
2,
2,
0,
1,
1,
0,
1,
2,
0,
0,
1,
1,
2,
2,
0,
0,
0,
1,
1,
0,
0,
0,
0,
0,
1,
0,
1,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
1,
1,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0
] |
[
"Subluxation",
"and",
"semantics:",
"a",
"corpus",
"linguistics",
"study",
"The",
"purpose",
"of",
"this",
"study",
"was",
"to",
"analyze",
"the",
"curriculum",
"of",
"one",
"chiropractic",
"college",
"in",
"order",
"to",
"discover",
"if",
"there",
"were",
"any",
"implicit",
"consensus",
"definitions",
"of",
"the",
"term",
"subluxation.",
"Using",
"the",
"software",
"WordSmith",
"Tools,",
"the",
"corpus",
"of",
"an",
"undergraduate",
"chiropractic",
"curriculum",
"was",
"analyzed",
"by",
"reviewing",
"collocated",
"terms",
"and",
"through",
"discourse",
"analysis",
"of",
"text",
"blocks",
"containing",
"words",
"based",
"on",
"the",
"root",
"'",
"sublux",
".'",
"It",
"was",
"possible",
"to",
"identify",
"3",
"distinct",
"concepts",
"which",
"were",
"each",
"referred",
"to",
"as",
"'",
"subluxation",
":'",
"i)",
"an",
"acute",
"or",
"instantaneous",
"injurious",
"event;",
"ii)",
"a",
"clinical",
"syndrome",
"which",
"manifested",
"post",
"-",
"injury;",
"iii)",
"a",
"physical",
"lesion,",
"i.e.",
"an",
"anatomical",
"or",
"physiological",
"derangement",
"which",
"in",
"most",
"instances",
"acted",
"as",
"a",
"pain",
"generator.",
"In",
"fact,",
"coherent",
"implicit",
"definitions",
"of",
"subluxation",
"exist",
"and",
"may",
"enjoy",
"broad",
"but",
"subconscious",
"acceptance.",
"However,",
"confusion",
"likely",
"arises",
"from",
"failure",
"to",
"distinguish",
"which",
"concept",
"an",
"author",
"or",
"speaker",
"is",
"referring",
"to",
"when",
"they",
"employ",
"the",
"term",
"subluxation."
] | [
1,
0,
1,
0,
1,
1,
1,
0,
1,
0,
0,
1,
0,
0,
1,
0,
1,
0,
0,
1,
1,
0,
0,
0,
1,
0,
0,
0,
0,
1,
1,
1,
0,
0,
1,
1,
0,
0,
1,
2,
2,
0,
1,
0,
0,
1,
1,
1,
0,
1,
0,
1,
1,
1,
0,
0,
1,
2,
0,
1,
1,
0,
1,
1,
0,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
1,
1,
0,
0,
1,
2,
0,
1,
1,
0,
1,
0,
0,
1,
1,
0,
0,
1,
0,
1,
1,
0,
0,
0,
1,
1,
0,
0,
1,
1,
0,
0,
1,
1,
1,
0,
1,
0,
0,
0,
0,
1,
0,
1,
1,
0,
1,
0,
0,
0,
1,
0,
1,
0,
1,
0,
1,
0,
1,
0,
1,
0,
0,
0,
1,
0,
1,
1
] |
[
"Espindolol",
"for",
"the",
"treatment",
"and",
"prevention",
"of",
"cachexia",
"in",
"patients",
"with",
"stage",
"III/IV",
"non-small",
"cell",
"lung",
"cancer",
"or",
"colorectal",
"cancer:",
"a",
"randomized,",
"double-blind,",
"placebo-controlled,",
"international",
"multicentre",
"phase",
"II",
"study",
"(the",
"ACT-ONE",
"trial)",
"Cancer",
"cachexia",
"is",
"a",
"major",
"cause",
"of",
"morbidity",
"and",
"mortality",
"with",
"no",
"widely",
"approved",
"treatment.",
"The",
"ACT-ONE",
"trial",
"is",
"a",
"randomized,",
"double-blind,",
"parallel",
"group,",
"placebo-controlled,",
"phase",
"II",
"multicentre",
"trial",
"in",
"patients",
"(25-80",
"years)",
"with",
"stages",
"III",
"or",
"IV",
"colorectal",
"cancer",
"or",
"non-small",
"cell",
"lung",
"cancer",
"-related",
"cachexia",
"that",
"tested",
"two",
"doses",
"of",
"espindolol",
"(a",
"novel",
"non-selective",
"β",
"blocker",
"with",
"central",
"5-HT1a",
"and",
"partial",
"β2",
"receptor",
"agonist",
"effects).",
"The",
"primary",
"endpoint",
"was",
"the",
"difference",
"in",
"the",
"rate",
"of",
"weight",
"change",
"over",
"16",
"weeks",
"(linear",
"mixed-effect",
"model",
"for",
"repeated",
"measures)",
"between",
"high-dose",
"espindolol",
"and",
"placebo.",
"Eighty-seven",
"patients",
"were",
"randomized",
"centrally",
"in",
"blocks",
"in",
"a",
"ratio",
"3:2:1",
"[42",
"high",
"dose,",
"10",
"mg",
"twice",
"daily",
"(bd):31",
"placebo",
":14",
"low",
"dose,",
"2.5",
"mg",
"bd].",
"High-dose",
"espindolol",
"produced",
"a",
"statistically",
"and",
"clinically",
"significant",
"weight",
"gain",
"(+0.54",
"kg/4",
"weeks,",
"95%",
"CI",
"0.38-0.70)",
"compared",
"with",
"a",
"weight",
"loss",
"on",
"placebo",
"(-0.21",
"kg/4",
"weeks,",
"95%",
"CI",
"-0.37-0.05);",
"P",
"<",
"0.0001.",
"High-dose",
"espindolol",
"produced",
"a",
"statistically",
"significant",
"increase",
"in",
"lean",
"body",
"mass,",
"whilst",
"changes",
"in",
"fat",
"mass",
"were",
"neutral.",
"Hand",
"grip",
"strength",
"significantly",
"(high",
"dose",
"-1.15",
"±",
"0.7",
"kg,",
"placebo",
"-3.51",
"±",
"0.8",
"kg",
"change",
"per",
"4",
"weeks;",
"P",
"=",
"0.0134),",
"stair",
"climbing",
"power,",
"and",
"6-min",
"walk",
"test",
"non-significantly",
"were",
"all",
"directionally",
"in",
"favour",
"of",
"high-dose",
"espindolol.",
"There",
"were",
"no",
"clinically",
"significant",
"differences",
"in",
"safety",
"signals",
"or",
"survival",
"between",
"treatment",
"groups,",
"although",
"a",
"numerical",
"excess",
"of",
"dyspnoea",
"was",
"seen",
"with",
"high-dose",
"espindolol",
"(19.1%)",
"compared",
"with",
"placebo",
"(3.2%).",
"This",
"positive",
"trial",
"showed",
"that",
"espindolol",
"10",
"mg",
"bd",
"significantly",
"reversed",
"weight",
"loss,",
"improved",
"fat",
"free",
"mass,",
"and",
"maintained",
"fat",
"mass",
"in",
"advanced",
"colorectal",
"cancer",
"and",
"non-small",
"cell",
"lung",
"cancer",
"-related",
"cachexia.",
"This",
"was",
"associated",
"with",
"a",
"significant",
"improvement",
"in",
"handgrip",
"strength,",
"supporting",
"the",
"further",
"investigation",
"of",
"10",
"mg",
"bd",
"espindolol",
"for",
"the",
"treatment",
"of",
"cancer",
"cachexia.",
"Although",
"not",
"powered",
"to",
"look",
"at",
"dose",
"response,",
"most",
"treatment",
"effects",
"for",
"low",
"dose",
"lay",
"between",
"high",
"dose",
"and",
"placebo,",
"suggesting",
"that",
"there",
"may",
"be",
"a",
"dose",
"response",
"in",
"the",
"effects",
"of",
"espindolol."
] | [
1,
0,
0,
1,
0,
1,
0,
1,
0,
1,
0,
1,
2,
2,
2,
2,
2,
0,
1,
2,
0,
1,
1,
1,
1,
2,
2,
2,
2,
2,
2,
2,
1,
2,
0,
0,
0,
1,
0,
1,
0,
1,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
1,
1,
1,
2,
1,
1,
2,
2,
2,
0,
1,
0,
0,
0,
1,
2,
2,
2,
2,
2,
0,
1,
2,
2,
2,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
1,
2,
2,
0,
1,
2,
0,
0,
1,
2,
2,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
1,
2,
2,
0,
0,
0,
0,
1,
1,
0,
1,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
0,
1,
0,
1,
2,
0,
0,
0,
1,
1,
0,
0,
1,
0,
1,
2,
1,
2,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
1,
2,
0,
0,
1,
2,
2,
0,
0,
0,
1,
2,
0,
0,
1,
2,
2,
0,
1,
2,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
2,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
1,
0,
0,
0,
1,
0,
0,
1,
2,
0,
0,
1,
0,
0,
0,
0,
0,
1,
2,
0,
1,
2,
2,
0,
0,
1,
2,
0,
0,
1,
2,
0,
1,
2,
2,
2,
0,
1,
0,
0,
1,
2,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
2,
0,
1,
0,
0,
1,
2,
0,
0,
1,
2,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
2,
1
] |
[
"Mono-sulfonated",
"tetrazolium",
"salt",
"based",
"NAD(P)H",
"detection",
"reagents",
"suitable",
"for",
"dehydrogenase",
"and",
"real-time",
"cell",
"viability",
"assays",
"Glutamate",
"dehydrogenase",
"(GDH)",
"catalyzes",
"the",
"oxidative",
"deamination",
"of",
"L-glutamate",
"and",
"is",
"important",
"for",
"several",
"biological",
"processes.",
"For",
"GDH",
"inhibitor",
"screening,",
"we",
"developed",
"a",
"novel",
"mono-sulfonated",
"tetrazolium",
"salt",
"(EZMTT),",
"which",
"can",
"be",
"synthesized",
"using",
"H2O2",
"oxidation",
"and",
"purified",
"easily",
"on",
"silica",
"gel",
"in",
"large",
"quantities.",
"The",
"EZMTT",
"detection",
"method",
"showed",
"linear",
"dose",
"responses",
"to",
"NAD(P)H,",
"dehydrogenase",
"concentration",
"and",
"cell",
"numbers.",
"In",
"E.",
"coli",
"GDH",
"assay,",
"the",
"EZMTT",
"method",
"showed",
"excellent",
"assay",
"reproducibility",
"with",
"a",
"Z",
"factor",
"of",
"0.9",
"and",
"caused",
"no",
"false",
"positives",
"in",
"the",
"presence",
"of",
"antioxidants",
"(such",
"as",
"BME).",
"Using",
"the",
"EZMTT",
"-",
"formazan",
"-",
"NAD(P)H",
"system,",
"we",
"showed",
"that",
"EGCG",
"is",
"a",
"potent",
"E.",
"coli",
"GDH",
"inhibitor",
"(IC50",
"45",
"nM)",
"and",
"identified",
"that",
"Ebselen,",
"a",
"multifunctional",
"thioredoxin",
"reductase",
"inhibitor,",
"inactivated",
"E.",
"coli",
"GDH",
"(IC50",
"213",
"nM).",
"In",
"cell-based",
"assays",
"at",
"0.5",
"mM",
"tetrazolium",
"concentration,",
"EZMTT",
"showed",
"essentially",
"no",
"toxicity",
"after",
"a",
"3-day",
"incubation,",
"whereas",
"40%",
"of",
"inhibition",
"was",
"observed",
"for",
"WST-8.",
"In",
"conclusion,",
"EZMTT",
"is",
"a",
"novel",
"tetrazolium",
"salt",
"which",
"provides",
"improved",
"features",
"that",
"are",
"suitable",
"for",
"dehydrogenases",
"and",
"real-time",
"cell-based",
"high-throughput",
"screening",
"(HTS)."
] | [
1,
2,
2,
0,
1,
1,
1,
0,
0,
1,
0,
1,
1,
2,
2,
1,
2,
1,
0,
0,
1,
1,
0,
1,
0,
0,
0,
0,
0,
1,
2,
0,
1,
1,
1,
0,
0,
0,
0,
1,
2,
2,
1,
0,
0,
0,
1,
0,
1,
1,
0,
1,
0,
0,
1,
2,
0,
0,
0,
0,
1,
1,
2,
0,
1,
2,
2,
0,
1,
1,
0,
0,
1,
2,
0,
1,
2,
1,
2,
0,
1,
0,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
1,
0,
1,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
1,
2,
1,
1,
1,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
1,
0,
1,
2,
1,
1,
0,
0,
0,
1,
2,
0,
0,
0,
1,
0,
1,
0,
0,
1,
2,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
1,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
1,
1,
2,
0
] |
[
"Is",
"Localized",
"Scleroderma",
"Caused",
"by",
"Borrelia",
"burgdorferi?",
"Despite",
"considerable",
"achievements",
"in",
"the",
"study",
"of",
"localized",
"scleroderma,",
"the",
"etiology",
"of",
"the",
"disease",
"has",
"not",
"been",
"investigated",
"completely.",
"Borrelia",
"burgdorferi",
"-the",
"agent",
"of",
"Lyme",
"disease",
"-is",
"suggested",
"to",
"be",
"one",
"of",
"the",
"possible",
"etiological",
"factors",
"of",
"localized",
"scleroderma.",
"However,",
"among",
"scientists,",
"this",
"hypothesis",
"is",
"quite",
"controversial.",
"We",
"have",
"conducted",
"investigations",
"of",
"the",
"level",
"of",
"IgM",
"and",
"IgG",
"class",
"antibodies",
"to",
"B.",
"burgdorferi",
"in",
"the",
"serum",
"of",
"patients",
"with",
"localized",
"scleroderma.",
"To",
"rationally",
"substantiate",
"the",
"role",
"of",
"B.",
"burgdorferi",
"in",
"the",
"occurrence",
"of",
"localized",
"scleroderma,",
"thirty-two",
"patients",
"with",
"localized",
"scleroderma",
"treated",
"at",
"an",
"in-patient",
"department",
"were",
"examined.",
"The",
"level",
"of",
"anti-Borrelia",
"antibodies",
"was",
"determined",
"in",
"ELISA.",
"Diagnostic",
"levels",
"of",
"IgM",
"and/or",
"IgG",
"were",
"detected",
"in",
"18.8%",
"of",
"patients",
"with",
"localized",
"scleroderma,",
"which",
"is",
"more",
"than",
"in",
"the",
"population",
"(p",
"<",
"0.01).",
"Positive",
"levels",
"of",
"anti-Borrelia",
"antibodies",
"in",
"patients",
"with",
"localized",
"scleroderma",
"confirm",
"the",
"borreliosis",
"nature",
"of",
"the",
"disease,",
"requiring",
"conduction",
"of",
"complex",
"antimicrobial",
"treatment."
] | [
0,
1,
2,
1,
2,
1,
2,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
1,
0,
0,
1,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
1,
2,
0,
0,
1,
0,
1,
0,
0,
1,
0,
0,
0,
1,
0,
0,
1,
0,
1,
0,
1,
0,
1,
0,
1,
2,
0,
0,
1,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
2,
0,
1,
0,
1,
2,
1,
0,
0,
1,
1,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
1,
1,
1,
0,
1,
0,
1,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
2,
0,
1,
2,
0,
1,
0,
1,
2,
0,
0,
1,
1,
2,
2,
2,
0,
0,
0,
0,
1,
1
] |
[
"RF",
"Ablation",
"of",
"Giant",
"Hemangiomas",
"Inducing",
"Acute",
"Renal",
"Failure:",
"A",
"Report",
"of",
"Two",
"Cases",
"In",
"patients",
"that",
"require",
"treatment",
"for",
"hepatic",
"giant",
"cavernous",
"hemangiomas",
"(GCH),",
"radiofrequency",
"ablation",
"(RFA)",
"has",
"been",
"suggested",
"to",
"represent",
"a",
"safe",
"and",
"effective",
"alternative",
"to",
"invasive",
"surgery.",
"In",
"a",
"recent",
"report",
"of",
"bipolar",
"RFA,",
"using",
"two",
"expandable",
"needle",
"electrodes,",
"was",
"uneventfully",
"performed",
"in",
"patients",
"with",
"large",
"GCH",
"(>10",
"cm).",
"The",
"objective",
"of",
"this",
"report",
"is",
"to",
"present",
"two",
"cases",
"in",
"which",
"bipolar",
"RFA",
"of",
"symptomatic",
"GCH",
"was",
"complicated",
"by",
"acute",
"kidney",
"injury.",
"In",
"2015",
"we",
"treated",
"two",
"patients",
"for",
"very",
"large",
"symptomatic",
"GCH",
"(15.7",
"and",
"25.0",
"cm)",
"with",
"bipolar",
"RFA",
"during",
"open",
"laparotomy.",
"In",
"both",
"patients",
"the",
"urine",
"showed",
"a",
"red-brown",
"discoloration",
"directly",
"after",
"the",
"ablation.",
"They",
"became",
"anuric",
"and",
"presented",
"with",
"progressive",
"dyspnea,",
"tachypnea,",
"and",
"tachycardia,",
"requiring",
"hemodialysis",
"for",
"a",
"period",
"of",
"1",
"month",
"in",
"one",
"case.",
"Lab",
"results",
"revealed",
"hemepigment",
"-",
"induced",
"acute",
"kidney.",
"Both",
"patients",
"fully",
"recovered",
"and",
"both",
"showed",
"a",
"complete",
"relief",
"of",
"symptoms",
"at",
"3",
"months",
"following",
"the",
"procedure.",
"RFA",
"for",
"large",
"GCHs",
"can",
"cause",
"hemepigment",
"-",
"induced",
"acute",
"kidney",
"injury",
"due",
"to",
"massive",
"intravascular",
"hemolysis.",
"The",
"presented",
"cases",
"suggest",
"that",
"caution",
"is",
"warranted",
"and",
"advocate",
"an",
"upper",
"limit",
"regarding",
"the",
"volume",
"of",
"GCHs",
"that",
"can",
"be",
"safely",
"ablated."
] | [
1,
2,
0,
1,
2,
1,
1,
2,
2,
0,
1,
0,
0,
1,
0,
1,
0,
1,
1,
0,
1,
1,
2,
2,
1,
1,
2,
1,
0,
0,
1,
0,
0,
0,
0,
0,
1,
1,
0,
1,
1,
0,
0,
0,
1,
0,
1,
2,
0,
0,
1,
2,
2,
0,
0,
1,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
1,
2,
0,
1,
1,
0,
1,
0,
1,
2,
2,
0,
0,
0,
1,
0,
1,
0,
0,
1,
1,
1,
0,
0,
0,
0,
0,
1,
2,
0,
1,
2,
0,
0,
1,
0,
1,
0,
0,
1,
2,
0,
0,
0,
1,
0,
0,
1,
0,
1,
0,
1,
2,
1,
0,
1,
0,
1,
0,
0,
1,
0,
0,
1,
0,
0,
1,
1,
2,
0,
1,
0,
1,
1,
2,
0,
1,
0,
1,
0,
0,
0,
0,
1,
1,
0,
1,
0,
0,
1,
0,
0,
1,
1,
0,
1,
1,
0,
0,
1,
0,
1,
1,
2,
2,
0,
0,
1,
1,
2,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
1
] |
[
"Identifying",
"and",
"integrating",
"patient",
"and",
"caregiver",
"perspectives",
"for",
"clinical",
"practice",
"guidelines",
"on",
"the",
"screening",
"and",
"management",
"of",
"infectious",
"microorganisms",
"in",
"hemodialysis",
"units",
"The",
"integration",
"of",
"patient",
"and",
"caregiver",
"input",
"into",
"guideline",
"development",
"can",
"help",
"to",
"ensure",
"that",
"clinical",
"care",
"addresses",
"patient",
"expectations,",
"priorities,",
"and",
"needs.",
"We",
"aimed",
"to",
"identify",
"topics",
"and",
"outcomes",
"salient",
"to",
"patients",
"and",
"caregivers",
"for",
"inclusion",
"in",
"the",
"Kidney",
"Health",
"Australia",
"Caring",
"for",
"Australasians",
"with",
"Renal",
"Impairment",
"(KHA",
"-",
"CARI)",
"clinical",
"practice",
"guideline",
"on",
"the",
"screening",
"and",
"management",
"of",
"infectious",
"microorganisms",
"in",
"hemodialysis",
"units.",
"A",
"facilitated",
"workshop",
"was",
"conducted",
"with",
"11",
"participants",
"(patients",
"[n",
"=",
"8],",
"caregivers",
"[n",
"=",
"3]).",
"Participants",
"identified",
"and",
"discussed",
"potential",
"topics",
"for",
"inclusion",
"in",
"the",
"guidelines,",
"which",
"were",
"compared",
"to",
"those",
"developed",
"by",
"the",
"guideline",
"working",
"group.",
"The",
"workshop",
"transcript",
"was",
"thematically",
"analyzed",
"to",
"identify",
"and",
"describe",
"the",
"reasons",
"underpinning",
"their",
"priorities.",
"Patients",
"and",
"caregivers",
"identified",
"a",
"range",
"of",
"topics",
"already",
"covered",
"by",
"the",
"scope",
"of",
"the",
"proposed",
"guidelines",
"and",
"also",
"suggested",
"additional",
"topics:",
"privacy",
"and",
"confidentiality,",
"psychosocial",
"care",
"during/after",
"disease",
"notification,",
"quality",
"of",
"transportation,",
"psychosocial",
"treatment",
"of",
"patients",
"in",
"isolation,",
"patient",
"/",
"caregiver",
"education",
"and",
"engagement,",
"and",
"patient",
"advocacy.",
"Five",
"themes",
"characterized",
"discussion",
"and",
"underpinned",
"their",
"choices:",
"shock",
"and",
"vulnerability,",
"burden",
"of",
"isolation,",
"fear",
"of",
"infection,",
"respect",
"for",
"privacy",
"and",
"confidentiality,",
"and",
"confusion",
"over",
"procedural",
"inconsistencies.",
"Patients",
"and",
"caregivers",
"emphasized",
"the",
"need",
"for",
"guidelines",
"to",
"address",
"patient",
"education",
"and",
"engagement,",
"and",
"the",
"psychosocial",
"implications",
"of",
"communication",
"and",
"provision",
"of",
"care",
"in",
"the",
"context",
"of",
"infectious",
"microorganisms",
"in",
"hemodialysis",
"units.",
"Integrating",
"patient",
"and",
"caregiver",
"perspectives",
"can",
"help",
"to",
"improve",
"the",
"relevance",
"of",
"guidelines",
"to",
"enhance",
"quality",
"of",
"care,",
"patient",
"experiences,",
"and",
"health",
"and",
"psychosocial",
"outcomes."
] | [
0,
0,
0,
1,
0,
1,
1,
0,
1,
2,
2,
0,
0,
1,
0,
0,
0,
1,
1,
0,
1,
2,
0,
0,
0,
1,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
1,
0,
1,
1,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
0,
0,
0,
0,
1,
2,
2,
1,
2,
2,
2,
2,
2,
1,
0,
1,
1,
2,
2,
0,
0,
1,
0,
0,
0,
1,
1,
0,
1,
2,
0,
0,
1,
0,
0,
0,
0,
1,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
2,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
1,
1,
2,
0,
1,
2,
1,
0,
1,
1,
2,
0,
1,
0,
1,
1,
0,
1,
2,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
1,
2,
2,
1,
2,
2,
1,
2,
2,
0,
1,
0,
1,
2,
2,
2,
1,
0,
1,
0,
0,
0,
0,
1,
0,
0,
1,
2,
0,
1,
0,
0,
1,
1,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
1,
1,
0,
1,
2,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
2,
1,
0,
0,
1,
0,
1,
1
] |
[
"Longitudinal",
"live",
"imaging",
"of",
"retinal",
"α-synuclein",
"::",
"GFP",
"deposits",
"in",
"a",
"transgenic",
"mouse",
"model",
"of",
"Parkinson's",
"Disease",
"/",
"Dementia",
"with",
"Lewy",
"Bodies",
"Abnormal",
"α-synuclein",
"(α-syn)",
"accumulation",
"in",
"the",
"CNS",
"may",
"underlie",
"neuronal",
"cell",
"and",
"synaptic",
"dysfunction",
"leading",
"to",
"motor",
"and",
"cognitive",
"deficits",
"in",
"synucleinopathies",
"including",
"Parkinson's",
"disease",
"(PD)",
"and",
"Dementia",
"with",
"Lewy",
"Bodies",
"(DLB).",
"Multiple",
"groups",
"demonstrated",
"α-syn",
"accumulation",
"in",
"CNS",
"accessory",
"structures,",
"including",
"the",
"eyes",
"and",
"olfactory",
"terminals,",
"as",
"well",
"as",
"in",
"peripheral",
"organs",
"of",
"Parkinsonian",
"patients.",
"Retinal",
"imaging",
"studies",
"of",
"mice",
"overexpressing",
"fused",
"α-syn",
"::",
"GFP",
"were",
"conducted",
"to",
"evaluate",
"the",
"presence",
"and",
"progression",
"of",
"retinal",
"pathology",
"in",
"a",
"PD",
"/",
"DLB",
"transgenic",
"mouse",
"model.",
"Bright-field",
"image",
"retinal",
"maps",
"and",
"fluorescent",
"images",
"were",
"acquired",
"at",
"1-month",
"intervals",
"for",
"3",
"months.",
"Retinal",
"imaging",
"revealed",
"the",
"accumulation",
"of",
"GFP",
"-tagged",
"α-syn",
"in",
"retinal",
"ganglion",
"cell",
"layer",
"and",
"in",
"the",
"edges",
"of",
"arterial",
"blood",
"vessels",
"in",
"the",
"transgenic",
"mice.",
"Double",
"labeling",
"studies",
"confirmed",
"that",
"the",
"α-syn",
"::",
"GFP",
"-positive",
"cells",
"were",
"retinal",
"ganglion",
"cells",
"containing",
"α-syn.",
"Accumulation",
"of",
"α-syn",
"persisted",
"in",
"the",
"same",
"cells",
"and",
"increased",
"with",
"age.",
"Accumulation",
"of",
"α-syn",
"::",
"GFP",
"was",
"reduced",
"by",
"immunization",
"with",
"single",
"chain",
"antibodies",
"against",
"α-syn.",
"In",
"conclusion,",
"longitudinal",
"live",
"imaging",
"of",
"the",
"retina",
"in",
"the",
"PDGF",
"-",
"α-syn",
"::",
"GFP",
"mice",
"might",
"represent",
"a",
"useful,",
"non-invasive",
"tool",
"to",
"monitor",
"the",
"fate",
"of",
"α-syn",
"accumulation",
"in",
"the",
"CNS",
"and",
"to",
"evaluate",
"the",
"therapeutic",
"effects",
"of",
"compounds",
"targeting",
"α-syn."
] | [
1,
2,
2,
0,
1,
1,
0,
1,
1,
0,
0,
1,
2,
2,
0,
1,
2,
0,
1,
2,
2,
2,
1,
1,
1,
1,
0,
0,
1,
0,
0,
1,
2,
0,
1,
1,
0,
0,
1,
0,
1,
2,
0,
1,
0,
1,
2,
1,
0,
1,
2,
2,
2,
1,
0,
0,
0,
1,
1,
0,
1,
1,
2,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
1,
1,
0,
1,
1,
1,
1,
2,
0,
1,
1,
0,
1,
0,
1,
0,
0,
0,
1,
0,
0,
0,
1,
0,
1,
1,
0,
0,
1,
0,
1,
1,
2,
2,
1,
2,
1,
2,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
1,
0,
1,
0,
1,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
1,
1,
2,
0,
0,
1,
2,
1,
2,
2,
0,
0,
0,
1,
0,
1,
0,
1,
0,
1,
2,
2,
0,
1,
1,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
1,
1,
0,
1,
0,
1,
0,
0,
0,
1,
0,
1,
2,
2,
0,
1,
0,
0,
1,
2,
2,
0,
0,
1,
0,
0,
1,
0,
1,
0,
1,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
1,
0,
0,
1,
0,
1,
2,
0,
1,
1,
1
] |
[
"Health",
"technology",
"assessment:",
"Off-site",
"sterilization",
"Every",
"year",
"millions",
"of",
"dollars",
"are",
"expended",
"to",
"equip",
"and",
"maintain",
"the",
"hospital",
"sterilization",
"centers,",
"and",
"our",
"country",
"is",
"not",
"an",
"exception",
"of",
"this",
"matter.",
"According",
"to",
"this,",
"it",
"is",
"important",
"to",
"use",
"more",
"effective",
"technologies",
"and",
"methods",
"in",
"health",
"system",
"in",
"order",
"to",
"reach",
"more",
"effectiveness",
"and",
"saving",
"in",
"costs.",
"This",
"study",
"was",
"conducted",
"with",
"the",
"aim",
"of",
"evaluating",
"the",
"technology",
"of",
"regional",
"sterilization",
"centers.",
"This",
"study",
"was",
"done",
"in",
"four",
"steps.",
"At",
"the",
"first",
"step,",
"safety",
"and",
"effectiveness",
"of",
"technology",
"was",
"studied",
"via",
"systematic",
"study",
"of",
"evidence.",
"The",
"next",
"step",
"was",
"done",
"to",
"evaluate",
"the",
"economical",
"aspect",
"of",
"off-site",
"sterilization",
"technology",
"using",
"gathered",
"data",
"from",
"systematic",
"review",
"of",
"the",
"texts",
"which",
"were",
"related",
"to",
"the",
"technology",
"and",
"costs",
"of",
"off-site",
"and",
"in-site",
"hospital",
"sterilization.",
"Third",
"step",
"was",
"conducted",
"to",
"collect",
"experiences",
"of",
"using",
"technology",
"in",
"some",
"selected",
"hospitals",
"around",
"the",
"world.",
"And",
"in",
"the",
"last",
"step",
"different",
"aspects",
"of",
"acceptance",
"and",
"use",
"of",
"this",
"technology",
"in",
"Iran",
"were",
"evaluated.",
"Review",
"of",
"the",
"selected",
"articles",
"indicated",
"that",
"efficacy",
"and",
"effectiveness",
"of",
"this",
"technology",
"is",
"Confirmed.",
"The",
"results",
"also",
"showed",
"that",
"using",
"this",
"method",
"is",
"not",
"economical",
"in",
"Iran.",
"According",
"to",
"the",
"revealed",
"evidences",
"and",
"also",
"cost",
"analysis,",
"due",
"to",
"shortage",
"of",
"necessary",
"substructures",
"and",
"economical",
"aspect,",
"installing",
"the",
"off-site",
"sterilization",
"health",
"technology",
"in",
"hospitals",
"is",
"not",
"possible",
"currently.",
"But",
"this",
"method",
"can",
"be",
"used",
"to",
"provide",
"sterilization",
"services",
"for",
"clinics",
"and",
"outpatients",
"centers."
] | [
1,
2,
2,
1,
1,
0,
1,
1,
2,
2,
0,
1,
0,
0,
0,
1,
0,
1,
1,
1,
0,
0,
1,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
1,
1,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
1,
0,
2,
0,
2,
0,
1,
0,
0,
0,
0,
1,
0,
1,
0,
1,
0,
1,
1,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
1,
0,
1,
0,
1,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
1,
1,
0,
1,
1,
1,
0,
0,
1,
0,
1,
1,
0,
0,
1,
0,
0,
1,
0,
0,
1,
0,
1,
0,
1,
0,
1,
1,
1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
1,
1,
0,
0,
1,
0,
0,
0,
0,
0,
1,
1,
0,
1,
0,
0,
0,
0,
1,
0,
1,
0,
1,
1,
0,
0,
1,
1,
1,
0,
1,
0,
1,
0,
0,
1,
0,
1,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
0,
0,
0,
1,
1,
0,
0,
1,
2,
0,
0,
1,
0,
0,
0,
0,
1,
2,
0,
0,
1,
1,
1,
2,
0,
1,
0,
1,
1,
1,
0,
0,
1,
0,
0,
0,
0,
1,
1,
1,
0,
1,
0,
1,
1
] |
[
"Weed",
"seed",
"inactivation",
"in",
"soil",
"mesocosms",
"via",
"biosolarization",
"with",
"mature",
"compost",
"and",
"tomato",
"processing",
"waste",
"amendments",
"Biosolarization",
"is",
"a",
"fumigation",
"alternative",
"that",
"combines",
"passive",
"solar",
"heating",
"with",
"amendment-driven",
"soil",
"microbial",
"activity",
"to",
"temporarily",
"create",
"antagonistic",
"soil",
"conditions,",
"such",
"as",
"elevated",
"temperature",
"and",
"acidity,",
"that",
"can",
"inactivate",
"weed",
"seeds",
"and",
"other",
"pest",
"propagules.",
"The",
"aim",
"of",
"this",
"study",
"was",
"to",
"use",
"a",
"mesocosm",
"-based",
"field",
"trial",
"to",
"assess",
"soil",
"heating,",
"pH,",
"volatile",
"fatty",
"acid",
"accumulation",
"and",
"weed",
"seed",
"inactivation",
"during",
"biosolarization.",
"Biosolarization",
"for",
"8",
"days",
"using",
"2%",
"mature",
"green",
"waste",
"compost",
"and",
"2",
"or",
"5%",
"tomato",
"processing",
"residues",
"in",
"the",
"soil",
"resulted",
"in",
"accumulation",
"of",
"volatile",
"fatty",
"acids",
"in",
"the",
"soil,",
"particularly",
"acetic",
"acid,",
"and",
">95%",
"inactivation",
"of",
"Brassica",
"nigra",
"and",
"Solanum",
"nigrum",
"seeds.",
"Inactivation",
"kinetics",
"data",
"showed",
"that",
"near",
"complete",
"weed",
"seed",
"inactivation",
"in",
"soil",
"was",
"achieved",
"within",
"the",
"first",
"5",
"days",
"of",
"biosolarization.",
"This",
"was",
"significantly",
"greater",
"than",
"the",
"inactivation",
"achieved",
"in",
"control",
"soils",
"that",
"were",
"solar",
"heated",
"without",
"amendment",
"or",
"were",
"amended",
"but",
"not",
"solar",
"heated.",
"The",
"composition",
"and",
"concentration",
"of",
"organic",
"matter",
"amendments",
"in",
"soil",
"significantly",
"affected",
"volatile",
"fatty",
"acid",
"accumulation",
"at",
"various",
"soil",
"depths",
"during",
"biosolarization.",
"Combining",
"solar",
"heating",
"with",
"organic",
"matter",
"amendment",
"resulted",
"in",
"accelerated",
"weed",
"seed",
"inactivation",
"compared",
"with",
"either",
"approach",
"alone.",
"©",
"2016",
"Society",
"of",
"Chemical",
"Industry."
] | [
1,
1,
1,
0,
1,
1,
0,
0,
0,
1,
2,
0,
1,
2,
2,
2,
0,
0,
0,
1,
0,
0,
0,
0,
1,
1,
0,
0,
1,
1,
2,
0,
0,
0,
1,
2,
2,
0,
0,
1,
2,
0,
1,
0,
0,
0,
1,
1,
0,
0,
1,
2,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
1,
0,
1,
2,
2,
1,
0,
1,
1,
1,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
0,
0,
1,
0,
1,
2,
2,
0,
0,
1,
0,
1,
2,
0,
0,
1,
0,
1,
2,
0,
1,
2,
1,
1,
1,
1,
0,
0,
0,
0,
1,
1,
1,
0,
1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
2,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
1,
0,
1,
2,
2,
0,
1,
0,
0,
1,
2,
2,
1,
0,
0,
1,
1,
0,
0,
0,
1,
1,
0,
1,
2,
2,
0,
0,
0,
1,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
[
"Phenotypic",
"and",
"genetic",
"heterogeneity",
"of",
"tumor",
"tissue",
"and",
"circulating",
"tumor",
"cells",
"in",
"patients",
"with",
"metastatic",
"castration-resistant",
"prostate",
"cancer:",
"A",
"report",
"from",
"the",
"PETRUS",
"prospective",
"study",
"Molecular",
"characterization",
"of",
"cancer",
"samples",
"is",
"hampered",
"by",
"tumor",
"tissue",
"availability",
"in",
"metastatic",
"castration-resistant",
"prostate",
"cancer",
"(mCRPC)",
"patients.",
"We",
"reported",
"the",
"results",
"of",
"prospective",
"PETRUS",
"study",
"of",
"biomarker",
"assessment",
"in",
"paired",
"primary",
"prostatic",
"tumors,",
"metastatic",
"biopsies",
"and",
"circulating",
"tumor",
"cells",
"(CTCs).",
"Among",
"54",
"mCRPC",
"patients",
"enrolled,",
"38",
"(70%)",
"had",
"biopsies",
"containing",
"more",
"than",
"50%",
"tumour",
"cells.",
"28",
"(52%)",
"patients",
"were",
"analyzed",
"for",
"both",
"tissue",
"samples",
"and",
"CTCs.",
"FISH",
"for",
"AR",
"-",
"amplification",
"and",
"TMPRSS2",
"-",
"ERG",
"translocation",
"were",
"successful",
"in",
"54%",
"and",
"32%",
"in",
"metastatic",
"biopsies",
"and",
"primary",
"tumors,",
"respectively.",
"By",
"comparing",
"CellSearch",
"and",
"filtration",
"(ISET)-enrichment",
"combined",
"to",
"four",
"color",
"immunofluorescent",
"staining,",
"we",
"showed",
"that",
"CellSearch",
"and",
"ISET",
"isolated",
"distinct",
"subpopulations",
"of",
"CTCs:",
"CTCs",
"undergoing",
"epithelial-to-mesenchymal",
"transition,",
"CTC",
"clusters",
"and",
"large",
"CTCs",
"with",
"cytomorphological",
"characteristics",
"but",
"no",
"detectable",
"markers",
"were",
"isolated",
"using",
"ISET.",
"Epithelial",
"CTCs",
"detected",
"by",
"the",
"CellSearch",
"were",
"mostly",
"lost",
"during",
"the",
"ISET-filtration.",
"AR",
"-",
"amplification",
"was",
"detected",
"in",
"CellSearch",
"-captured",
"CTCs,",
"but",
"not",
"in",
"ISET",
"-enriched",
"CTCs",
"which",
"harbor",
"exclusively",
"AR",
"gain",
"of",
"copies.",
"Eighty-eight",
"percent",
"concordance",
"for",
"ERG-rearrangement",
"was",
"observed",
"between",
"metastatic",
"biopsies",
"and",
"CTCs",
"even",
"if",
"additional",
"ERG-alteration",
"patterns",
"were",
"detected",
"in",
"ISET",
"-enriched",
"CTCs",
"indicating",
"a",
"higher",
"heterogeneity",
"in",
"CTCs.",
"Molecular",
"screening",
"of",
"metastatic",
"biopsies",
"is",
"achievable",
"in",
"a",
"multicenter",
"context.",
"Our",
"data",
"indicate",
"that",
"CTCs",
"detected",
"by",
"the",
"CellSearch",
"and",
"the",
"ISET-filtration",
"systems",
"are",
"not",
"only",
"phenotypically",
"but",
"also",
"genetically",
"different.",
"Close",
"attention",
"must",
"be",
"paid",
"to",
"CTC",
"characterization",
"since",
"neither",
"approach",
"tested",
"here",
"fully",
"reflects",
"the",
"tremendous",
"phenotypic",
"and",
"genetic",
"heterogeneity",
"present",
"in",
"CTCs",
"from",
"mCRPC",
"patients."
] | [
1,
0,
1,
2,
0,
1,
2,
0,
1,
2,
2,
0,
1,
0,
1,
2,
2,
2,
0,
1,
0,
0,
1,
2,
2,
1,
2,
2,
2,
2,
0,
1,
0,
1,
2,
0,
0,
1,
2,
2,
2,
1,
1,
0,
1,
0,
1,
0,
1,
2,
2,
0,
1,
2,
0,
0,
0,
1,
2,
1,
1,
0,
1,
2,
2,
1,
0,
0,
1,
1,
0,
0,
0,
0,
1,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
1,
0,
0,
1,
2,
0,
1,
1,
0,
1,
0,
1,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
1,
2,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
0,
1,
1,
0,
1,
0,
1,
0,
0,
1,
2,
1,
2,
0,
1,
1,
0,
1,
1,
0,
0,
1,
1,
0,
1,
0,
1,
1,
1,
1,
0,
0,
1,
0,
0,
0,
0,
0,
1,
1,
0,
1,
0,
1,
0,
1,
0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
0,
1,
0,
0,
1,
0,
0,
0,
0,
1,
0,
0,
0,
1,
1,
0,
1,
0,
0,
0,
1,
0,
0,
1,
0,
1,
0,
1,
0,
0,
1,
1,
0,
1,
1,
1,
0,
1,
1,
0,
0,
0,
0,
1,
2,
0,
1,
0,
0,
1,
1,
0,
0,
1,
0,
0,
1,
2,
0,
0,
0,
1,
0,
0,
1,
1,
0,
0,
0,
0,
0,
0,
1,
1,
0,
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
1,
0,
1,
1
] |
[
"Role",
"of",
"the",
"Membrane",
"for",
"Mechanosensing",
"by",
"Tethered",
"Channels",
"Biologically",
"important",
"membrane",
"channels",
"are",
"gated",
"by",
"force",
"at",
"attached",
"tethers.",
"Here,",
"we",
"generically",
"characterize",
"the",
"nontrivial",
"interplay",
"of",
"force,",
"membrane",
"tension,",
"and",
"channel",
"deformations",
"that",
"can",
"affect",
"gating.",
"A",
"central",
"finding",
"is",
"that",
"minute",
"conical",
"channel",
"deformation",
"under",
"force",
"leads",
"to",
"significant",
"energy",
"release",
"during",
"opening.",
"We",
"also",
"calculate",
"channel-channel",
"interactions",
"and",
"show",
"that",
"they",
"can",
"amplify",
"the",
"force",
"sensitivity",
"of",
"tethered",
"channels."
] | [
0,
0,
0,
1,
0,
1,
0,
1,
1,
1,
0,
1,
2,
0,
1,
0,
1,
0,
1,
1,
0,
0,
0,
0,
0,
0,
0,
0,
1,
1,
2,
0,
1,
1,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
1,
0,
1,
0,
0,
0,
1,
2,
0,
1,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
1,
1,
0,
1,
1
] |