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sequencelengths 8
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[
"Expression",
"of",
"the",
"Mir-133",
"and",
"Bcl-2",
"could",
"be",
"affected",
"by",
"swimming",
"training",
"in",
"the",
"heart",
"of",
"ovariectomized",
"rats",
"The",
"beneficial",
"and",
"more",
"potent",
"role",
"of",
"exercise",
"to",
"prevent",
"heart",
"apoptosis",
"in",
"ovariectomized",
"rats",
"has",
"been",
"known.",
"The",
"aim",
"of",
"this",
"study",
"was",
"to",
"examine",
"the",
"effects",
"of",
"swimming",
"training",
"on",
"cardiac",
"expression",
"of",
"Bcl-2,",
"and",
"Mir-133",
"levels",
"and",
"glycogen",
"changes",
"in",
"the",
"myocyte.",
"Forty",
"animals",
"were",
"separated",
"into",
"four",
"groups",
"as",
"control,",
"sham,",
"ovariectomy",
"(OVX)",
"and",
"ovariectomized",
"group",
"with",
"8",
"weeks",
"swimming",
"training",
"(OVX.E).",
"Training",
"effects",
"were",
"evaluated",
"by",
"measuring",
"lipid",
"profiles,",
"Bcl-2",
"and",
"Mir-133",
"expression",
"levels",
"in",
"the",
"cardiac",
"tissue.",
"Grafts",
"were",
"analyzed",
"by",
"reverse",
"transcription-polymerase",
"chain",
"reaction",
"for",
"Bcl-2",
"mRNA",
"and",
"Mir-133",
"and",
"by",
"Western",
"blot",
"for",
"Bcl-2",
"protein.",
"Ovariectomy",
"down-regulated",
"Bcl-2",
"and",
"Mir-133",
"expression",
"levels",
"in",
"the",
"cardiac",
"tissue,",
"and",
"swimming",
"training",
"up-regulated",
"their",
"expression",
"significantly",
"(P<0.05).",
"Our",
"results",
"showed",
"that",
"regular",
"exercise",
"as",
"a",
"physical",
"replacement",
"therapy",
"could",
"prevent",
"and",
"improve",
"the",
"effects",
"of",
"estrogen",
"deficiency",
"in",
"the",
"cardia."
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[
"Hepatitis",
"E",
"virus",
"in",
"donor",
"plasma",
"collected",
"in",
"Japan",
"Human",
"hepatitis",
"E",
"virus",
"(HEV)",
"is",
"prevalent",
"worldwide.",
"Iatrogenic",
"HEV",
"has",
"recently",
"been",
"identified",
"based",
"on",
"the",
"reports",
"of",
"transfusion-transmitted",
"cases.",
"The",
"detection",
"rate",
"of",
"HEV-RNA",
"and",
"seroprevalence",
"of",
"HEV-IgG",
"/",
"IgM",
"have",
"been",
"regionally",
"evaluated",
"in",
"Japan,",
"and",
"donor",
"plasma",
"collected",
"in",
"Hokkaido",
"is",
"currently",
"screened",
"by",
"nucleic",
"acid",
"amplification",
"testing.",
"However,",
"the",
"detection",
"rate",
"of",
"HEV-RNA",
"in",
"blood",
"donors",
"in",
"Japan",
"outside",
"of",
"Hokkaido",
"has",
"not",
"been",
"reported.",
"A",
"total",
"of",
"620",
"140",
"qualified",
"donor",
"plasma",
"samples",
"from",
"Japanese",
"regions",
"excluding",
"Hokkaido",
"were",
"tested",
"for",
"HEV-RNA",
"(pools",
"of",
"50",
"or",
"500)",
"between",
"2004",
"and",
"2014.",
"HEV-RNA-positive",
"plasma",
"bags",
"were",
"identified,",
"and",
"the",
"HEV",
"viral",
"load,",
"genotype",
"and",
"anti-HEV",
"immunoglobulin",
"(Ig)G/IgM",
"were",
"evaluated.",
"The",
"detection",
"rate",
"of",
"HEV-RNA",
"(pools",
"of",
"50)",
"was",
"1/15",
"075",
"and",
"higher",
"in",
"eastern",
"than",
"in",
"western",
"Japan.",
"All",
"36",
"HEV-RNA-positive",
"samples",
"were",
"genotype",
"3",
"with",
"viral",
"load",
"ranging",
"from",
"<1·69",
"to",
"7·22",
"log10",
"copies/ml.",
"Our",
"detection",
"rate",
"of",
"HEV-RNA",
"in",
"donor",
"populations",
"in",
"Japan",
"outside",
"Hokkaido",
"(1/15",
"075",
"donations)",
"is",
"generally",
"lower",
"than",
"reported",
"in",
"Europe",
"and",
"lower",
"than",
"previously",
"reported",
"for",
"Hokkaido",
"(1/8173",
"donations).",
"As",
"methods",
"varied,",
"we",
"cannot",
"exclude",
"that",
"these",
"differences",
"are",
"reflective",
"of",
"differing",
"RNA",
"detection",
"limits.",
"In",
"contrast",
"to",
"Hokkaido",
"where",
"genotype",
"4",
"has",
"been",
"reported",
"among",
"blood",
"donations,",
"all",
"our",
"positive",
"donations",
"were",
"genotype",
"3,",
"which",
"is",
"less",
"pathogenic."
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[
"Individual",
"differences",
"in",
"behavioral",
"activation",
"and",
"cardiac",
"vagal",
"control",
"influence",
"affective",
"startle",
"modification",
"The",
"startle",
"response",
"(SR)",
"has",
"a",
"close",
"relationship",
"with",
"stress",
"responses.",
"Startle",
"modification",
"(SRM)",
"has",
"been",
"widely",
"used",
"to",
"study",
"stress",
"disorders",
"(e.g.,",
"posttraumatic",
"stress",
"disorder).",
"The",
"framework",
"of",
"the",
"behavioral",
"inhibition",
"and",
"activation",
"systems",
"(BIS",
"/",
"BAS)",
"has",
"been",
"thought",
"to",
"correspond",
"with",
"withdrawal",
"and",
"approach",
"motivational",
"processes",
"underlying",
"affective",
"SRM",
"and",
"can",
"influence",
"stress",
"reactivity.",
"Vagally-mediated",
"cardiac",
"activity",
"as",
"indexed",
"by",
"heart",
"rate",
"variability",
"(HRV)",
"has",
"been",
"associated",
"with",
"SRM",
"and",
"regulatory",
"processes",
"during",
"stress.",
"In",
"the",
"present",
"study,",
"the",
"influence",
"of",
"individual",
"differences",
"in",
"the",
"BIS",
"/",
"BAS",
"and",
"resting",
"HRV",
"on",
"affective",
"SRM",
"were",
"examined.",
"Eighty-six",
"subjects",
"viewed",
"affective",
"pictures",
"while",
"acoustic",
"SR",
"stimuli",
"were",
"delivered.",
"Individual",
"differences",
"in",
"motivation",
"were",
"measured",
"by",
"the",
"BIS/BAS",
"scales.",
"The",
"magnitude",
"of",
"SR",
"was",
"assessed",
"as",
"electromyographic",
"activity",
"of",
"the",
"SR",
"eyeblink",
"during",
"pictures",
"of",
"different",
"valences.",
"Resting",
"HRV",
"was",
"derived",
"from",
"electrocardiography.",
"In",
"contrast",
"to",
"previous",
"studies,",
"the",
"present",
"results",
"showed",
"that",
"startle",
"inhibition",
"and",
"potentiation",
"were",
"related",
"to",
"BAS",
"and",
"HRV,",
"but",
"not",
"to",
"BIS.",
"There",
"was",
"also",
"an",
"interaction",
"of",
"BAS",
"and",
"HRV,",
"indicating",
"that",
"the",
"relationship",
"between",
"HRV",
"and",
"SRM",
"strengthened",
"as",
"BAS",
"scores",
"decreased.",
"The",
"present",
"findings",
"suggest",
"that",
"BAS",
"may",
"relate",
"to",
"both",
"withdrawal",
"and",
"approach,",
"and",
"trait",
"stress",
"reactivity",
"is",
"influence",
"d",
"by",
"BAS",
"and",
"cardiac",
"vagal",
"activity.",
"In",
"addition,",
"BAS",
"moderates",
"the",
"relationship",
"between",
"cardiac",
"vagal",
"activity",
"and",
"SRM.",
"These",
"findings",
"have",
"both",
"theoretical",
"and",
"practical",
"implications",
"for",
"the",
"study",
"of",
"SRM,",
"stress",
"disorders,",
"and",
"health."
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[
"Efficient",
"patient",
"modeling",
"for",
"visuo",
"-",
"haptic",
"VR",
"simulation",
"using",
"a",
"generic",
"patient",
"atlas",
"This",
"work",
"presents",
"a",
"new",
"time-saving",
"virtual",
"patient",
"modeling",
"system",
"by",
"way",
"of",
"example",
"for",
"an",
"existing",
"visuo",
"-",
"haptic",
"training",
"and",
"planning",
"virtual",
"reality",
"(VR)",
"system",
"for",
"percutaneous",
"transhepatic",
"cholangio-drainage",
"(PTCD).",
"Our",
"modeling",
"process",
"is",
"based",
"on",
"a",
"generic",
"patient",
"atlas",
"to",
"start",
"with.",
"It",
"is",
"defined",
"by",
"organ",
"-",
"specific",
"optimized",
"models,",
"method",
"modules",
"and",
"parameters,",
"i.e.",
"mainly",
"individual",
"segmentation",
"masks,",
"transfer",
"functions",
"to",
"fill",
"the",
"gaps",
"between",
"the",
"masks",
"and",
"intensity",
"image",
"data.",
"In",
"this",
"contribution,",
"we",
"show",
"how",
"generic",
"patient",
"atlases",
"can",
"be",
"generalized",
"to",
"new",
"patient",
"data.",
"The",
"methodology",
"consists",
"of",
"patient",
"-",
"specific,",
"locally-adaptive",
"transfer",
"functions",
"and",
"dedicated",
"modeling",
"methods",
"such",
"as",
"multi-atlas",
"segmentation,",
"vessel",
"filtering",
"and",
"spline-modeling.",
"Our",
"full",
"image",
"volume",
"segmentation",
"algorithm",
"yields",
"median",
"DICE",
"coefficients",
"of",
"0.98,",
"0.93,",
"0.82,",
"0.74,",
"0.51",
"and",
"0.48",
"regarding",
"soft-tissue,",
"liver,",
"bone,",
"skin,",
"blood",
"and",
"bile",
"vessels",
"for",
"ten",
"test",
"patients",
"and",
"three",
"selected",
"reference",
"patients.",
"Compared",
"to",
"standard",
"slice-wise",
"manual",
"contouring",
"time",
"saving",
"is",
"remarkable.",
"Our",
"segmentation",
"process",
"shows",
"out",
"efficiency",
"and",
"robustness",
"for",
"upper",
"abdominal",
"puncture",
"simulation",
"systems.",
"This",
"marks",
"a",
"significant",
"step",
"toward",
"establishing",
"patient",
"-",
"specific",
"training",
"and",
"hands-on",
"planning",
"systems",
"in",
"a",
"clinical",
"environment."
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[
"Achilles",
"tendon",
"material",
"properties",
"are",
"greater",
"in",
"the",
"jump",
"leg",
"of",
"jumping",
"athletes",
"The",
"Achilles",
"tendon",
"(AT)",
"must",
"adapt",
"to",
"meet",
"changes",
"in",
"demands.",
"This",
"study",
"explored",
"AT",
"adaptation",
"by",
"comparing",
"properties",
"within",
"the",
"jump",
"and",
"non-jump",
"legs",
"of",
"jumping",
"athletes.",
"Non-jumping",
"control",
"athletes",
"were",
"included",
"to",
"control",
"limb",
"dominance",
"effects.",
"AT",
"properties",
"were",
"assessed",
"in",
"the",
"preferred",
"(jump)",
"and",
"non-preferred",
"(lead)",
"jumping",
"legs",
"of",
"male",
"collegiate-level",
"long",
"and/or",
"high",
"jump",
"(jumpers;",
"n=10)",
"and",
"cross-country",
"(controls;",
"n=10)",
"athletes.",
"Cross-sectional",
"area",
"(CSA),",
"elongation,",
"and",
"force",
"during",
"isometric",
"contractions",
"were",
"used",
"to",
"estimate",
"the",
"morphological,",
"mechanical",
"and",
"material",
"properties",
"of",
"the",
"ATs",
"bilaterally.",
"Jumpers",
"exposed",
"their",
"ATs",
"to",
"more",
"force",
"and",
"stress",
"than",
"controls",
"(all",
"p≤0.03).",
"AT",
"force",
"and",
"stress",
"were",
"also",
"greater",
"in",
"the",
"jump",
"leg",
"of",
"both",
"jumpers",
"and",
"controls",
"than",
"in",
"the",
"lead",
"leg",
"(all",
"p<0.05).",
"Jumpers",
"had",
"17.8%",
"greater",
"AT",
"stiffness",
"and",
"24.4%",
"greater",
"Young's",
"modulus",
"in",
"their",
"jump",
"leg",
"compared",
"to",
"lead",
"leg",
"(all",
"p<0.05).",
"There",
"were",
"no",
"jump",
"versus",
"lead",
"leg",
"differences",
"in",
"AT",
"stiffness",
"or",
"Young's",
"modulus",
"within",
"controls",
"(all",
"p>0.05).",
"ATs",
"chronically",
"exposed",
"to",
"elevated",
"mechanical",
"loading",
"were",
"found",
"to",
"exhibit",
"greater",
"mechanical",
"(stiffness)",
"and",
"material",
"(Young's",
"modulus)",
"properties."
] | [
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[
"Sinus",
"augmentation",
"using",
"a",
"histone",
"deacetylase",
"inhibitor",
"in",
"a",
"calcium",
"sulfate",
"carrier",
"in",
"rabbit:",
"A",
"pilot",
"study",
"Histone",
"deacetylase",
"inhibitors",
"such",
"as",
"sodium",
"butyrate",
"(SB)",
"have",
"been",
"suggested",
"to",
"be",
"promising",
"candidate",
"small",
"molecules",
"for",
"bone",
"regeneration.",
"In",
"this",
"study,",
"the",
"capacity",
"of",
"SB",
"loaded",
"onto",
"calcium",
"sulfate",
"(CaS)",
"to",
"enhance",
"bone",
"formation",
"was",
"investigated",
"in",
"a",
"rabbit",
"sinus",
"model.",
"Following",
"preparation",
"of",
"the",
"sinus",
"access",
"window",
"on",
"a",
"randomly",
"selected",
"side,",
"SB",
"loaded",
"onto",
"CaS",
"(CaS",
"/",
"SB)",
"was",
"grafted",
"in",
"five",
"rabbits,",
"and",
"CaS",
"alone",
"(control)",
"was",
"grafted",
"in",
"another",
"five",
"rabbits.",
"The",
"animals",
"were",
"euthanized",
"after",
"4",
"weeks",
"for",
"radiographic,",
"histometric,",
"and",
"immunohistochemical",
"analyses.",
"There",
"was",
"a",
"statistically",
"significant",
"difference",
"in",
"the",
"total",
"augmented",
"volume",
"between",
"the",
"groups",
"in",
"the",
"radiographic",
"analysis",
"(158.22",
"±",
"39.31",
"mm(3)",
"and",
"107.09",
"±",
"39.69",
"mm(3),",
"respectively,",
"p",
"=",
"0.040).",
"The",
"CaS",
"/",
"SB",
"group",
"showed",
"a",
"larger",
"portion",
"of",
"mature",
"lamellar",
"bone",
"and",
"a",
"higher",
"level",
"of",
"mineralization",
"of",
"bone",
"trabeculae,",
"characterized",
"by",
"more",
"intense",
"labeling",
"with",
"osteocalcin",
"compared",
"with",
"the",
"control",
"group",
"in",
"the",
"immunohistochemical",
"analysis.",
"The",
"number",
"of",
"osteocalcin-positive",
"cells",
"within",
"the",
"central",
"area",
"of",
"the",
"augmented",
"sinus",
"was",
"significantly",
"higher",
"in",
"the",
"CaS",
"/",
"SB",
"group",
"than",
"in",
"the",
"control",
"group",
"(179",
"±",
"26.0",
"mm(2)",
"and",
"123",
"±",
"33.2",
"mm(2),",
"respectively,",
"p",
"=",
"0.027).",
"In",
"conclusion,",
"CaS",
"/",
"SB",
"exhibited",
"superior",
"osteogenic",
"potential,",
"especially",
"in",
"the",
"central",
"portion",
"of",
"the",
"augmented",
"sinus",
"as",
"well",
"as",
"improvement",
"of",
"the",
"volume",
"maintenance",
"for",
"sinus",
"augmentation.",
"©",
"2016",
"Wiley",
"Periodicals,",
"Inc.",
"J",
"Biomed",
"Mater",
"Res",
"Part",
"B:",
"Appl",
"Biomater,",
"2016."
] | [
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[
"Juglone",
"ameliorates",
"skin",
"wound",
"healing",
"by",
"promoting",
"skin",
"cell",
"migration",
"through",
"Rac1",
"/",
"Cdc42",
"/",
"PAK",
"pathway",
"Skin",
"cell",
"regeneration",
"and",
"wound",
"healing",
"are",
"key",
"processes",
"in",
"the",
"recovery",
"from",
"skin",
"injuries.",
"Rapid",
"cell",
"migration",
"and",
"regeneration",
"of",
"skin",
"cells",
"lead",
"to",
"faster",
"and",
"better",
"healing",
"of",
"wounded",
"skin.",
"In",
"the",
"present",
"study,",
"we",
"aimed",
"to",
"investigate",
"the",
"wound",
"healing",
"potential",
"of",
"juglone,",
"a",
"naturally",
"occurring",
"Pin1",
"inhibitor",
"found",
"in",
"walnuts.",
"Cultured",
"skin",
"cells",
"(NHDF",
"and",
"HaCaT)",
"and",
"hairless",
"mice",
"were",
"treated",
"with",
"juglone",
"after",
"wound",
"creation",
"to",
"examine",
"its",
"effects",
"on",
"cell",
"migration",
"and",
"wound",
"healing",
"rate.",
"The",
"expressions",
"of",
"cell",
"migration",
"related",
"proteins",
"(Rac1,",
"Cdc42,",
"and",
"α-PAK),",
"collagen",
"deposition,",
"and",
"angiogenesis",
"were",
"analyzed.",
"Juglone",
"treatment",
"resulted",
"in",
"faster",
"rate",
"of",
"growth",
"and",
"migration",
"and",
"recovered",
"cell",
"morphology,",
"particularly",
"at",
"a",
"concentration",
"of",
"5",
"µM,",
"in",
"skin",
"cells",
"compared",
"to",
"the",
"untreated",
"group.",
"In",
"vivo",
"experiments",
"showed",
"that",
"mice",
"treated",
"with",
"juglone",
"showed",
"faster",
"wound",
"healing",
"rate",
"with",
"better",
"skin",
"morphology",
"and",
"collagen",
"deposition",
"than",
"the",
"vehicle",
"group.",
"Furthermore,",
"juglone",
"increased",
"the",
"activation",
"and/or",
"expression",
"of",
"Cdc42,",
"Rac1,",
"and",
"α-pak",
"in",
"HaCaT",
"cells,",
"and",
"resulted",
"in",
"enhanced",
"angiogenesis",
"in",
"endothelial",
"cells",
"(HUVECs).",
"Juglone",
"also",
"activated",
"MAPKs",
"signaling",
"by",
"activation",
"of",
"ERK,",
"JNK,",
"and",
"p38",
"proteins.",
"Taken",
"together,",
"these",
"data",
"suggest",
"that",
"juglone",
"may",
"be",
"a",
"potential",
"candidate",
"for",
"wound",
"healing",
"and",
"skin",
"regeneration",
"which",
"ameliorates",
"wound",
"healing",
"mainly",
"by",
"promoting",
"skin",
"cell",
"migration",
"through",
"Rac1",
"/",
"Cdc42",
"/",
"PAK",
"pathway."
] | [
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[
"Tibia",
"stress",
"fracture",
"secondary",
"to",
"obsessive",
"compulsive",
"disorder",
"Obsessive",
"compulsive",
"disorder",
"(OCD)",
"is",
"a",
"chronic",
"psychiatric",
"disorder",
"characterized",
"by",
"obsessions",
"and",
"compulsions.",
"Early-onset",
"OCD",
"is",
"one",
"of",
"the",
"most",
"common",
"mental",
"illnesses",
"of",
"children",
"and",
"adolescents,",
"with",
"a",
"prevalence",
"of",
"1%",
"to",
"3%.",
"It",
"is",
"related",
"to",
"worse",
"lifespan",
"symptoms",
"and",
"prognosis.",
"Therefore,",
"the",
"treatment",
"of",
"OCD",
"in",
"children",
"and",
"adolescent",
"has",
"gained",
"importance.",
"If",
"it",
"is",
"not",
"treated",
"successfully,",
"the",
"compulsive",
"behaviors",
"may",
"cause",
"extreme",
"stress",
"for",
"children",
"and",
"their",
"parents.",
"Although",
"minor",
"complications",
"of",
"OCD",
"are",
"commonly",
"observed,",
"major",
"complications",
"are",
"considerably",
"rare",
"due",
"to",
"the",
"nature",
"of",
"compulsive",
"behaviors.",
"Apparently,",
"loss",
"of",
"vision,",
"autocastration,",
"rectal",
"prolapse",
"are",
"examples",
"of",
"major",
"complications",
"secondary",
"to",
"OCD.",
"As",
"far",
"as",
"we",
"know,",
"it",
"is",
"the",
"first",
"case",
"of",
"tibia",
"stress",
"fracture",
"secondary",
"to",
"OCD.",
"In",
"the",
"present",
"case",
"report,",
"we",
"will",
"discuss",
"tibia",
"stress",
"fracture",
"developing",
"secondary",
"to",
"compulsive",
"behavior",
"due",
"to",
"OCD."
] | [
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[
"Mutation",
"profiles",
"of",
"synchronous",
"colorectal",
"cancers",
"from",
"a",
"patient",
"with",
"Lynch",
"syndrome",
"suggest",
"distinct",
"oncogenic",
"pathways",
"Patients",
"with",
"Lynch",
"syndrome",
"often",
"present",
"with",
"multiple",
"synchronous",
"or",
"metachronous",
"colorectal",
"cancers",
"(CRCs).",
"The",
"presence",
"of",
"multiple",
"CRCs",
"with",
"distinct",
"genetic",
"profiles",
"and",
"driver",
"mutations",
"could",
"complicate",
"treatment",
"as",
"each",
"cancer",
"may",
"respond",
"differently",
"to",
"therapy.",
"Studies",
"of",
"sporadic",
"CRCs",
"suggested",
"that",
"synchronous",
"tumors",
"have",
"distinct",
"etiologies,",
"but",
"could",
"not",
"rule",
"out",
"differences",
"in",
"genetic",
"background.",
"The",
"presence",
"of",
"multiple",
"cancers",
"in",
"a",
"patient",
"with",
"a",
"predisposing",
"mutation",
"provides",
"an",
"opportunity",
"to",
"profile",
"synchronous",
"cancers",
"in",
"the",
"same",
"genetic",
"background.",
"Here,",
"we",
"describe",
"the",
"case",
"of",
"a",
"patient",
"with",
"Lynch",
"syndrome",
"that",
"presented",
"with",
"six",
"synchronous",
"CRCs.",
"Microsatellite",
"instability",
"(MSI)",
"and",
"genomic",
"profiling",
"indicated",
"that",
"each",
"lesion",
"had",
"a",
"unique",
"pattern",
"of",
"instability",
"and",
"a",
"distinct",
"profile",
"of",
"affected",
"genes.",
"These",
"findings",
"support",
"the",
"idea",
"that",
"in",
"Lynch",
"syndrome,",
"synchronous",
"CRCs",
"can",
"develop",
"in",
"parallel",
"with",
"distinct",
"mutation",
"profiles",
"and",
"that",
"these",
"differences",
"may",
"inform",
"treatment",
"decisions."
] | [
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[
"Sensitization",
"to",
"the",
"motor",
"stimulant",
"effects",
"of",
"3,4-methylenedioxypyrovalerone",
"(MDPV)",
"and",
"cross-sensitization",
"to",
"methamphetamine",
"in",
"rats",
"In",
"recent",
"years,",
"there",
"has",
"been",
"a",
"dramatic",
"increase",
"in",
"abuse",
"of",
"the",
"synthetic",
"cathinone",
"3,4-methylenedioxypyrovalerone",
"(MDPV),",
"often",
"in",
"combination",
"with",
"other",
"illicit",
"stimulants.",
"We",
"sought",
"to",
"determine",
"if",
"repeated",
"exposure",
"to",
"MDPV",
"would",
"produce",
"sensitization",
"to",
"the",
"motor",
"stimulant",
"effects",
"of",
"the",
"drug,",
"and",
"whether",
"cross-sensitization",
"would",
"develop",
"with",
"the",
"stimulant",
"effects",
"of",
"methamphetamine",
"(METH).",
"Male",
"Sprague-Dawley",
"rats",
"were",
"administered",
"MDPV",
"(1",
"or",
"5",
"mg/kg)",
"or",
"saline",
"once",
"daily",
"for",
"5",
"days",
"at",
"24",
"hour",
"intervals,",
"or",
"were",
"administered",
"MDPV",
"(1",
"mg/kg)",
"or",
"saline",
"once",
"daily",
"for",
"5",
"days",
"at",
"48",
"hour",
"intervals.",
"For",
"cross-sensitization",
"experiments,",
"rats",
"were",
"administered",
"METH",
"(1",
"mg/kg)",
"or",
"MDPV",
"(1",
"or",
"5",
"mg/kg)",
"once",
"daily",
"for",
"5",
"days",
"at",
"48",
"hour",
"intervals,",
"and",
"following",
"a",
"5",
"day",
"incubation",
"period,",
"were",
"given",
"an",
"acute",
"challenge",
"injection",
"of",
"either",
"MDPV",
"(0.5",
"mg/kg)",
"or",
"METH",
"(0.5",
"mg/kg),",
"respectively.",
"Rats",
"repeatedly",
"administered",
"MDPV",
"(1",
"mg/kg)",
"every",
"48",
"hours,",
"but",
"not",
"every",
"24",
"hours,",
"demonstrated",
"increased",
"motor",
"activity",
"when",
"given",
"either",
"a",
"subsequent",
"challenge",
"of",
"MDPV",
"(0.5",
"mg/kg",
"i.p.)",
"or",
"METH",
"(0.5",
"mg/kg),",
"indicating",
"the",
"development",
"of",
"behavioral",
"sensitization",
"and",
"cross-sensitization,",
"respectively.",
"Moreover,",
"rats",
"repeatedly",
"administered",
"METH",
"(1",
"mg/kg)",
"every",
"48",
"hours",
"did",
"not",
"exhibit",
"cross-sensitization",
"to",
"the",
"motor",
"stimulating",
"effects",
"of",
"a",
"subsequent",
"challenge",
"with",
"MDPV",
"(0.5",
"mg/kg).",
"These",
"results",
"suggest",
"that",
"specific",
"patterns",
"of",
"MDPV",
"administration",
"may",
"lead",
"to",
"lasting",
"changes",
"in",
"behavioral",
"responses",
"to",
"subsequent",
"METH",
"exposure."
] | [
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] |
[
"Nonamplification",
"ERBB2",
"genomic",
"alterations",
"in",
"5605",
"cases",
"of",
"recurrent",
"and",
"metastatic",
"breast",
"cancer:",
"An",
"emerging",
"opportunity",
"for",
"anti-HER2",
"targeted",
"therapies",
"Activating,",
"nonamplification",
"ERBB2",
"mutations",
"(ERBB2mut)",
"are",
"not",
"detected",
"by",
"immunohistochemistry",
"(IHC)",
"or",
"fluorescence",
"in",
"situ",
"hybridization",
"(FISH),",
"but",
"are",
"detected",
"by",
"DNA",
"sequencing",
"and",
"may",
"predict",
"clinical",
"responses",
"to",
"human",
"epidermal",
"growth",
"factor",
"receptor",
"(HER2)-",
"targeted",
"therapy.",
"The",
"authors",
"queried",
"5605",
"advanced/metastatic",
"breast",
"cancers",
"(mBC)",
"to",
"uncover",
"the",
"frequency",
"of",
"ERBB2mut",
"genomic",
"alterations.",
"Clinical",
"responses",
"to",
"anti-HER2",
"therapeutics",
"were",
"identified.",
"DNA",
"was",
"extracted",
"from",
"40",
"µm",
"of",
"formalin-fixed",
"paraffin-embedded",
"(FFPE)",
"sections.",
"Comprehensive",
"genomic",
"profiling",
"(CGP)",
"was",
"used",
"to",
"evaluate",
"up",
"to",
"315",
"genes",
"(592×",
"mean",
"coverage",
"depth).",
"Results",
"were",
"analyzed",
"for",
"base",
"substitutions,",
"short",
"indels,",
"copy",
"number",
"changes,",
"and",
"selected",
"rearrangements.",
"Of",
"5605",
"cases,",
"698",
"(12.5%)",
"featured",
"ERBB2",
"alterations,",
"including",
"596",
"(10.6%)",
"ERBB2",
"amplifications",
"(ERBB2amp)",
"and",
"138",
"(2.4%)",
"ERBB2mut;",
"38",
"cases",
"(0.7%)",
"had",
"co-occurring",
"ERBB2amp",
"and",
"ERBB2mut.",
"ERBB2mut",
"predominantly",
"affected",
"the",
"kinase",
"(124",
"cases;",
"90%)",
"or",
"extracellular",
"(15",
"cases;",
"11%)",
"domains.",
"Both",
"primary",
"BC",
"(52",
"cases;",
"38%)",
"and",
"metastatic",
"site",
"biopsies",
"(86",
"cases;",
"62%)",
"were",
"found",
"to",
"harbor",
"ERBB2mut,",
"which",
"were",
"distributed",
"across",
"carcinoma",
"not",
"otherwise",
"specified",
"(NOS)",
"(69",
"cases;",
"50%),",
"invasive",
"ductal",
"carcinoma",
"(IDC)",
"(40",
"cases;",
"29%),",
"invasive",
"lobular",
"carcinoma",
"(ILC)",
"(27",
"cases;",
"20%),",
"and",
"mucinous",
"mBC",
"(2",
"cases;",
"1%).",
"Genes",
"commonly",
"coaltered",
"with",
"ERBB2",
"were",
"tumor",
"protein",
"53",
"(TP53)",
"(49%);",
"phosphatidylinositol",
"3-kinase",
"catalytic",
"subunit",
"alpha",
"(PIK3CA)",
"(42%);",
"cadherin",
"1,",
"type",
"1",
"(CDH1)",
"(37%);",
"MYC",
"(17%);",
"and",
"cyclin",
"D1",
"protein",
"(CCND1)",
"(16%).",
"CDH1",
"mutations",
"were",
"enriched",
"in",
"ERBB2mut",
"mBC",
"(P<0.0006)",
"and",
"associated",
"with",
"recurrent",
"mBC.",
"Selected",
"patients",
"with",
"ERBB2mut,",
"without",
"ERBB2amp,",
"who",
"responded",
"to",
"anti-HER2",
"targeted",
"therapies",
"are",
"presented",
"herein.",
"Within",
"this",
"large",
"series,",
"1.8%",
"of",
"cases",
"harbored",
"ERBB2mut,",
"which",
"are",
"undetectable",
"by",
"standard-of-care",
"IHC",
"or",
"FISH",
"tests.",
"Metastatic",
"BC",
"driven",
"by",
"ERBB2mut",
"respond",
"to",
"anti-HER2",
"targeted",
"therapies,",
"and",
"expanding",
"clinical",
"trials",
"designed",
"to",
"detect",
"ERBB2mut",
"by",
"CGP",
"and",
"optimize",
"targeted",
"treatments",
"are",
"warranted.",
"Cancer",
"2016.",
"©",
"2016",
"American",
"Cancer",
"Society.",
"Cancer",
"2016;122:2654-2662.",
"©",
"2016",
"American",
"Cancer",
"Society."
] | [
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1,
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1,
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1,
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1,
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1,
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0,
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1,
1,
0,
1,
2,
1,
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0,
0,
1,
0,
0,
1,
1,
2,
0,
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1,
2,
0,
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[
"Parasympathetic",
"Activity",
"and",
"Bronchial",
"Hyperresponsiveness",
"in",
"Athletes",
"A",
"high",
"prevalence",
"of",
"asthma",
"and",
"bronchial",
"hyperresponsiveness",
"(BHR)",
"is",
"reported",
"in",
"swimmers",
"and",
"cross-country",
"skiers.",
"It",
"has",
"been",
"suggested",
"that",
"increased",
"parasympathetic",
"nervous",
"activity",
"is",
"involved",
"in",
"asthma",
"development",
"in",
"endurance",
"athletes.",
"We",
"aimed",
"to",
"assess",
"the",
"associations",
"of",
"BHR",
"to",
"parasympathetic",
"activity",
"in",
"healthy",
"and",
"asthmatic",
"swimmers",
"and",
"cross-country",
"skiers",
"and",
"healthy",
"non",
"athletes.",
"Parasympathetic",
"activity",
"was",
"measured",
"by",
"pupillometry",
"and",
"heart",
"rate",
"variability",
"at",
"the",
"onset",
"of",
"exercise",
"with",
"the",
"cardiac",
"vagal",
"index",
"calculated",
"in",
"28",
"cross-country",
"skiers",
"(♂18/♀10),",
"29",
"swimmers",
"(♂17/♀12),",
"and",
"30",
"healthy",
"nonathlete",
"controls",
"(♂14/♀16)",
"on",
"two",
"different",
"days.",
"All",
"subjects",
"performed",
"a",
"methacholine",
"bronchial",
"challenge",
"with",
"the",
"provocation",
"dose",
"causing",
"20%",
"decrease",
"in",
"the",
"forced",
"expiratory",
"volume",
"in",
"1",
"s",
"calculated",
"(PD20met).",
"Data",
"were",
"analyzed",
"by",
"robust",
"regression",
"analysis",
"and",
"presented",
"as",
"β",
"coefficients",
"with",
"95%",
"confidence",
"intervals",
"(CI).",
"PD20met",
"was",
"negatively",
"associated",
"with",
"cardiac",
"vagal",
"index",
"(-13.9,",
"95%",
"CI",
"=",
"-26.8",
"to",
"-1.0)",
"in",
"all",
"subjects.",
"When",
"adjusted",
"to",
"the",
"type",
"of",
"sport,",
"this",
"association",
"was",
"stronger",
"in",
"swimmers",
"(-8.3,",
"95%",
"CI",
"=",
"-13.0",
"to",
"-3.6)",
"as",
"compared",
"with",
"controls",
"and",
"nonsignificant",
"in",
"cross-country",
"skiers.",
"Percent",
"pupil",
"constriction",
"was",
"significantly",
"associated",
"with",
"PD20met",
"in",
"swimmers",
"(-9.4,",
"95%",
"CI",
"=",
"-15.4",
"to",
"-3.4)",
"only",
"after",
"adjusting",
"for",
"the",
"type",
"of",
"sport.",
"Fourteen",
"swimmers",
"(48%)",
"and",
"16",
"cross-country",
"skiers",
"(57%)",
"had",
"doctor-diagnosed",
"asthma",
"in",
"combination",
"with",
"current",
"BHR",
"and/or",
"current",
"use",
"of",
"asthma",
"drugs.",
"Seventy-two",
"percent",
"swimmers,",
"44%",
"cross-country",
"skiers,",
"and",
"39%",
"controls",
"had",
"a",
"PD20met",
"≤8",
"μmol",
"(P",
"=",
"0.015).",
"Fourteen",
"swimmers",
"had",
"a",
"PD20met",
"≤2",
"μmol",
"as",
"compared",
"with",
"one",
"cross-country",
"skier",
"(P",
"<",
"0.001).",
"Parasympathetic",
"activity",
"measured",
"in",
"the",
"heart",
"is",
"more",
"closely",
"related",
"to",
"BHR",
"as",
"compared",
"with",
"parasympathetic",
"activity",
"measured",
"in",
"the",
"pupils.",
"The",
"type",
"of",
"sport",
"influences",
"BHR",
"severity",
"and",
"its",
"relationship",
"to",
"parasympathetic",
"activity."
] | [
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1,
0,
0,
0,
0,
0,
0,
1,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
1,
1,
0,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
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1,
1,
1,
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] |
[
"Chemical",
"Composition",
"and",
"Biological",
"Activity",
"of",
"Essential",
"Oils",
"from",
"Different",
"Species",
"of",
"Piper",
"from",
"Panama",
"The",
"chemical",
"composition",
"of",
"leaf",
"essential",
"oils",
"from",
"11",
"species",
"of",
"Piper",
"from",
"Panama",
"was",
"analyzed",
"by",
"a",
"combination",
"GC-FID",
"and",
"GC-MS",
"procedures.",
"Six",
"of",
"them",
"had",
"sesquiterpene",
"hydrocarbons",
"as",
"major",
"constituents,",
"three",
"were",
"characterized",
"by",
"monoterpene",
"hydrocarbons,",
"one",
"by",
"a",
"diterpene,",
"and",
"one",
"by",
"a",
"phenylpropanoid,",
"dillapiole.",
"The",
"main",
"components",
"identified",
"in",
"each",
"species",
"were:",
"cembratrienol",
"(25.4",
"%)",
"in",
"Piper",
"augustum;",
"β-pinene",
"(26.6",
"%)",
"in",
"Piper",
"corrugatum;",
"α-pinene",
"(19.4",
"%)",
"in",
"Piper",
"curtispicum;",
"trans-β-farnesene",
"(63.7",
"%)",
"in",
"Piper",
"darienense;",
"p-cymene",
"(43.9",
"%)",
"in",
"Piper",
"grande;",
"dillapiole",
"(57.7",
"%)",
"in",
"Piper",
"hispidum;",
"linalool",
"(14.5",
"%),",
"α-phellandrene",
"(13.8",
"%),",
"and",
"limonene",
"(12.2",
"%)",
"in",
"Piper",
"jacquemontianum;",
"β-caryophyllene",
"(45.2",
"%)",
"in",
"Piper",
"longispicum;",
"linalool",
"(16.5",
"%),",
"α-phellandrene",
"(11.8",
"%),",
"limonene",
"(11.4",
"%),",
"and",
"p-cymene",
"(9.0",
"%)",
"in",
"Piper",
"multiplinervium;",
"β-selinene",
"(19.0",
"%),",
"β-elemene",
"(16.1",
"%),",
"and",
"α-selinene",
"(15.5",
"%)",
"in",
"Piper",
"reticulatum;",
"and",
"germacrene",
"D",
"(19.7",
"%)",
"in",
"Piper",
"trigonum.",
"The",
"essential",
"oils",
"of",
"P.",
"hispidum",
"and",
"P.",
"longispicum",
"at",
"a",
"concentration",
"of",
"250",
"µg/mL",
"showed",
"larvicidal",
"activity",
"against",
"Aedes",
"aegypti,",
"while",
"the",
"oils",
"from",
"P.",
"curtispicum,",
"P.",
"multiplinervium,",
"P.",
"reticulatum,",
"and",
"P.",
"trigonum",
"were",
"inactive",
"(LC100",
"≥",
"500",
"µg/mL).",
"The",
"essential",
"oils",
"of",
"P.",
"grande,",
"P.",
"jacquemontianum,",
"and",
"P.",
"multiplinervium",
"showed",
"no",
"significant",
"antifungal",
"activity",
"(MIC",
">",
"250",
"µg/mL)",
"against",
"several",
"yeasts",
"and",
"filamentous",
"fungal",
"strains."
] | [
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1,
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1,
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0,
1,
0,
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1,
2,
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1,
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1,
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1,
2,
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2
] |
[
"Spatial",
"analysis",
"of",
"drug",
"poisoning",
"deaths",
"in",
"the",
"American",
"West,",
"particularly",
"Utah",
"Most",
"states",
"in",
"the",
"Western",
"US",
"have",
"high",
"rates",
"of",
"drug",
"poisoning",
"death",
"(DPD),",
"especially",
"New",
"Mexico,",
"Nevada,",
"Arizona",
"and",
"Utah",
"(UT).",
"This",
"seems",
"paradoxical",
"in",
"UT",
"where",
"illicit",
"drug",
"use,",
"smoking",
"and",
"drinking",
"rates",
"are",
"low.",
"To",
"investigate",
"this,",
"spatial",
"analysis",
"of",
"county",
"level",
"DPD",
"data",
"and",
"other",
"relevant",
"factors",
"in",
"the",
"Western",
"US",
"and",
"UT",
"was",
"undertaken.",
"Poisson",
"kriging",
"was",
"used",
"to",
"smooth",
"the",
"DPD",
"data,",
"populate",
"data",
"gaps",
"and",
"improve",
"the",
"reliability",
"of",
"rates",
"recorded",
"in",
"sparsely",
"populated",
"counties.",
"Links",
"between",
"DPD",
"and",
"economic,",
"environmental,",
"health,",
"lifestyle,",
"and",
"demographic",
"factors",
"were",
"investigated",
"at",
"four",
"scales",
"using",
"multiple",
"linear",
"regression.",
"LDS",
"church",
"membership",
"and",
"altitude,",
"factors",
"not",
"previously",
"considered,",
"were",
"included.",
"Spatial",
"change",
"in",
"the",
"strength",
"and",
"sign",
"of",
"relationships",
"was",
"investigated",
"using",
"geographically",
"weighted",
"regression",
"and",
"significant",
"DPD",
"clusters",
"were",
"identified",
"using",
"the",
"Local",
"Moran's",
"I.",
"Economic",
"factors,",
"like",
"the",
"sharp",
"social",
"gradient",
"between",
"rural",
"and",
"urban",
"areas",
"were",
"important",
"to",
"DPD",
"throughout",
"the",
"west.",
"Higher",
"DPD",
"rates",
"were",
"also",
"found",
"in",
"areas",
"of",
"higher",
"elevation",
"and",
"the",
"desert",
"rural",
"areas",
"in",
"the",
"south.",
"The",
"unique",
"characteristics",
"of",
"DPD",
"in",
"UT",
"in",
"terms",
"of",
"health",
"and",
"lifestyle",
"factors,",
"as",
"well",
"as",
"the",
"demographic",
"structure",
"of",
"DPD",
"in",
"the",
"most",
"LDS",
"populous",
"states",
"(UT,",
"Idaho,",
"Wyoming),",
"suggest",
"that",
"high",
"DPD",
"in",
"heavily",
"LDS",
"areas",
"are",
"predominantly",
"prescription",
"opioid",
"related",
"whereas",
"in",
"other",
"Western",
"states",
"a",
"larger",
"proportion",
"of",
"DPD",
"might",
"come",
"from",
"illicit",
"drugs.",
"Drug",
"policies",
"need",
"to",
"be",
"adapted",
"to",
"the",
"geographical",
"differences",
"in",
"the",
"dominant",
"type",
"of",
"drug",
"causing",
"death.",
"Educational",
"materials",
"need",
"to",
"be",
"marketed",
"to",
"the",
"demographic",
"groups",
"at",
"greatest",
"risk",
"and",
"take",
"into",
"account",
"differences",
"in",
"population",
"characteristics",
"between",
"and",
"within",
"States.",
"Some",
"suggestions",
"about",
"how",
"such",
"adaptations",
"can",
"be",
"made",
"are",
"given",
"and",
"future",
"research",
"needs",
"outlined."
] | [
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1,
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1,
0,
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1,
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1,
0,
0,
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0,
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1,
2,
0,
1,
0,
0,
0,
1,
2,
2,
1,
1,
1,
0,
0,
0,
1,
0,
1,
2,
2,
0,
0,
0,
1,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
1,
0,
0,
0,
1,
2,
1,
2,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
0,
1,
0,
1,
1,
2,
0,
0,
0,
1,
0,
0,
1,
2,
0,
1,
1,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
1,
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[
"Electrochemically",
"assisted",
"deposition",
"of",
"strontium",
"modified",
"magnesium",
"phosphate",
"on",
"titanium",
"surfaces",
"Electrochemically",
"assisted",
"deposition",
"was",
"utilized",
"to",
"produce",
"ceramic",
"coatings",
"on",
"the",
"basis",
"of",
"magnesium",
"ammonium",
"phosphate",
"(struvite)",
"on",
"corundum",
"-",
"blasted",
"titanium",
"surfaces.",
"By",
"the",
"addition",
"of",
"defined",
"concentrations",
"of",
"strontium",
"nitrate",
"to",
"the",
"coating",
"electrolyte",
"Sr(2+)",
"ions",
"were",
"successfully",
"incorporated",
"into",
"the",
"struvite",
"matrix.",
"By",
"variation",
"of",
"deposition",
"parameters",
"it",
"was",
"possible",
"to",
"fabricate",
"coatings",
"with",
"different",
"kinetics",
"of",
"Sr(2+)",
"into",
"physiological",
"media,",
"whereas",
"the",
"release",
"of",
"therapeutically",
"relevant",
"strontium",
"doses",
"could",
"be",
"sustained",
"over",
"several",
"weeks.",
"Morphological",
"and",
"crystallographic",
"examinations",
"of",
"the",
"immersed",
"coatings",
"revealed",
"that",
"the",
"degradation",
"of",
"struvite",
"and",
"the",
"release",
"of",
"Sr(2+)",
"ions",
"were",
"accompanied",
"by",
"a",
"transformation",
"of",
"the",
"coating",
"to",
"a",
"calcium",
"phosphate",
"based",
"phase",
"similar",
"to",
"low-crystalline",
"hydroxyapatite.",
"These",
"findings",
"showed",
"that",
"strontium",
"doped",
"struvite",
"coatings",
"may",
"provide",
"a",
"promising",
"degradable",
"coating",
"system",
"for",
"the",
"local",
"application",
"of",
"strontium",
"or",
"other",
"biologically",
"active",
"metal",
"ions",
"in",
"the",
"implant-bone",
"interface."
] | [
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[
"Inflamed",
"skin",
"predisposes",
"to",
"sensitization",
"to",
"less",
"potent",
"allergens",
"Irritant",
"dermatitis,",
"caused",
"by",
"genetic",
"barrier",
"dysfunction",
"in",
"atopic",
"dermatitis",
"or",
"wet",
"work",
"in",
"hand",
"dermatitis,",
"induces",
"innate",
"immune",
"response",
"that",
"might",
"predispose",
"to",
"allergic",
"contact",
"sensitization",
"to",
"less",
"potent",
"sensitizers.",
"We",
"sought",
"to",
"determine",
"if",
"positive",
"patch",
"test",
"results",
"to",
"less",
"potent",
"allergens",
"are",
"more",
"prevalent",
"in",
"patients",
"with",
"a",
"history",
"of",
"childhood",
"flexural",
"dermatitis",
"or",
"current",
"wet",
"work.",
"We",
"examined",
"our",
"database",
"of",
"patients",
"presenting",
"to",
"a",
"contact",
"dermatitis",
"clinic",
"tested",
"to",
"potential",
"contact",
"allergens",
"as",
"indicated",
"by",
"their",
"history.",
"Allergens",
"from",
"our",
"most",
"recent",
"standard",
"were",
"studied",
"if",
"they",
"could",
"be",
"classified",
"as",
"weak,",
"moderate,",
"or",
"strong",
"sensitizers",
"based",
"on",
"published",
"data",
"from",
"the",
"local",
"lymph",
"node",
"assay.",
"Patients",
"were",
"stratified",
"by",
"a",
"history",
"of",
"childhood",
"-",
"onset",
"flexural",
"dermatitis",
"as",
"a",
"proxy",
"for",
"atopic",
"dermatitis",
"and",
"by",
"occupation.",
"History",
"of",
"childhood",
"-",
"onset",
"dermatitis",
"predisposed",
"to",
"contact",
"allergy",
"to",
"weak",
"sensitizers",
"and",
"wet",
"work",
"to",
"medium",
"-",
"potency",
"sensitizers.",
"Neither",
"predisposed",
"to",
"contact",
"allergy",
"from",
"strong",
"sensitizers.",
"Association",
"cannot",
"prove",
"causation.",
"We",
"conclude",
"that",
"strong",
"sensitizers",
"do",
"not",
"require",
"wet",
"work",
"or",
"atopy",
"to",
"cause",
"sensitization.",
"Barrier",
"defects",
"associated",
"with",
"childhood",
"eczema",
"and",
"wet",
"work",
"may",
"promote",
"sensitization",
"to",
"weak",
"antigens."
] | [
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[
"Transcription",
"rate",
"and",
"transcript",
"length",
"drive",
"formation",
"of",
"chromosomal",
"interaction",
"domain",
"boundaries",
"Chromosomes",
"in",
"all",
"organisms",
"are",
"highly",
"organized",
"and",
"divided",
"into",
"multiple",
"chromosomal",
"interaction",
"domains,",
"or",
"topological",
"domains.",
"Regions",
"of",
"active,",
"high",
"transcription",
"help",
"establish",
"and",
"maintain",
"domain",
"boundaries,",
"but",
"precisely",
"how",
"this",
"occurs",
"remains",
"unclear.",
"Here,",
"using",
"fluorescence",
"microscopy",
"and",
"chromosome",
"conformation",
"capture",
"in",
"conjunction",
"with",
"deep",
"sequencing",
"(Hi-C),",
"we",
"show",
"that",
"in",
"Caulobacter",
"crescentus,",
"both",
"transcription",
"rate",
"and",
"transcript",
"length,",
"independent",
"of",
"concurrent",
"translation,",
"drive",
"the",
"formation",
"of",
"domain",
"boundaries.",
"We",
"find",
"that",
"long,",
"highly",
"expressed",
"genes",
"do",
"not",
"form",
"topological",
"boundaries",
"simply",
"through",
"the",
"inhibition",
"of",
"supercoil",
"diffusion.",
"Instead,",
"our",
"results",
"support",
"a",
"model",
"in",
"which",
"long,",
"active",
"regions",
"of",
"transcription",
"drive",
"local",
"decompaction",
"of",
"the",
"chromosome,",
"with",
"these",
"more",
"open",
"regions",
"of",
"the",
"chromosome",
"forming",
"spatial",
"gaps",
"in",
"vivo",
"that",
"diminish",
"contacts",
"between",
"DNA",
"in",
"neighboring",
"domains.",
"These",
"insights",
"into",
"the",
"molecular",
"forces",
"responsible",
"for",
"domain",
"formation",
"in",
"Caulobacter",
"likely",
"generalize",
"to",
"other",
"bacteria",
"and",
"possibly",
"eukaryotes."
] | [
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1,
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[
"Molecular",
"characterization",
"of",
"a",
"novel",
"putative",
"ampelovirus",
"tentatively",
"named",
"grapevine",
"leafroll-associated",
"virus",
"13",
"A",
"novel",
"putative",
"ampelovirus",
"was",
"detected",
"in",
"grapevines",
"that",
"showed",
"typical",
"leafroll",
"symptoms",
"and",
"was",
"tentatively",
"named",
"grapevine",
"leafroll-associated",
"virus",
"(GLRaV)-13",
"following",
"the",
"series",
"of",
"numbering",
"of",
"other",
"GLRaVs.",
"The",
"complete",
"genome",
"of",
"GLRaV-13",
"comprised",
"17,608",
"nt",
"and",
"contained",
"eleven",
"putative",
"open",
"reading",
"frames,",
"showing",
"genetic",
"features",
"similar",
"to",
"those",
"of",
"viruses",
"belonging",
"to",
"subgroup",
"I",
"of",
"genus",
"Ampelovirus.",
"Phylogenetic",
"trees",
"based",
"on",
"the",
"RNA-dependent",
"RNA",
"polymerase,",
"heat",
"shock",
"protein",
"70",
"homolog,",
"and",
"coat",
"protein",
"showed",
"that",
"GLRaV-13",
"had",
"the",
"closest,",
"but",
"still",
"distant,",
"relationship",
"to",
"GLRaV-1",
"in",
"the",
"subgroup",
"I",
"cluster."
] | [
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[
"Joint",
"Development",
"Involves",
"a",
"Continuous",
"Influx",
"of",
"Gdf5",
"-",
"Positive",
"Cells",
"Synovial",
"joints",
"comprise",
"several",
"tissue",
"types,",
"including",
"articular",
"cartilage,",
"the",
"capsule,",
"and",
"ligaments.",
"All",
"of",
"these",
"compartments",
"are",
"commonly",
"assumed",
"to",
"originate",
"from",
"an",
"early",
"set",
"of",
"Gdf5",
"-",
"expressing",
"progenitors",
"populating",
"the",
"interzone",
"domain.",
"Here,",
"we",
"provide",
"evidence",
"that",
"joints",
"develop",
"through",
"a",
"continuous",
"influx",
"of",
"cells",
"into",
"the",
"interzone,",
"where",
"they",
"contribute",
"differentially",
"to",
"forming",
"joint",
"tissues.",
"Using",
"a",
"knockin",
"Gdf5",
"-",
"CreER(T2)",
"mouse,",
"we",
"show",
"that",
"early",
"labeling",
"of",
"Gdf5",
"-",
"positive",
"interzone",
"cells",
"failed",
"to",
"mark",
"the",
"entire",
"organ.",
"Conversely,",
"multiple",
"Cre",
"activation",
"steps",
"indicated",
"a",
"contribution",
"of",
"these",
"cells",
"to",
"various",
"joint",
"compartments",
"later",
"in",
"development.",
"Spatiotemporal",
"differences",
"between",
"Gdf5",
"and",
"tdTomato",
"reporter",
"expression",
"support",
"the",
"notion",
"of",
"a",
"continuous",
"recruitment",
"process.",
"Finally,",
"differential",
"contribution",
"of",
"Gdf5",
"-",
"positive",
"cells",
"to",
"various",
"tissues",
"suggests",
"that",
"the",
"spatiotemporal",
"dynamics",
"of",
"Gdf5",
"expression",
"may",
"instruct",
"lineage",
"divergence.",
"This",
"work",
"supports",
"the",
"influx",
"model",
"of",
"joint",
"development,",
"which",
"may",
"apply",
"to",
"other",
"organogenic",
"processes."
] | [
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[
"Everyday",
"(in)equality",
"at",
"home:",
"complex",
"constructions",
"of",
"gender",
"in",
"South",
"African",
"families",
"High",
"rates",
"of",
"violence",
"and",
"HIV",
"have",
"been",
"documented",
"within",
"the",
"South",
"African",
"context.",
"Constructions",
"of",
"masculinity",
"and",
"femininity",
"that",
"position",
"men",
"as",
"dominant",
"and",
"highly",
"sexually",
"active",
"and",
"women",
"as",
"subordinate",
"and",
"acquiescent",
"have",
"been",
"found",
"to",
"contribute",
"towards",
"gender",
"inequality.",
"This",
"inequality",
"is",
"in",
"turn",
"related",
"to",
"negative",
"health",
"consequences,",
"specifically",
"violence",
"against",
"women,",
"children,",
"and",
"other",
"men,",
"as",
"well",
"as",
"sexual",
"risk.",
"Within",
"this",
"context",
"it",
"becomes",
"important",
"to",
"explore",
"how",
"problematic",
"constructions",
"of",
"gender",
"are",
"being",
"(re)",
"produced",
"and",
"how",
"these",
"constructions",
"are",
"being",
"challenged.",
"Families",
"have",
"been",
"identified",
"as",
"key",
"sites",
"in",
"which",
"gender",
"is",
"both",
"constructed",
"and",
"enacted",
"on",
"a",
"daily",
"basis",
"and",
"it",
"is",
"within",
"this",
"space",
"that",
"children",
"are",
"first",
"exposed",
"to",
"notions",
"of",
"gender.",
"This",
"article",
"draws",
"from",
"a",
"study",
"that",
"was",
"intended",
"to",
"expand",
"on",
"the",
"limited",
"understandings",
"of",
"the",
"ways",
"in",
"which",
"gender",
"(in)equality",
"is",
"constructed",
"and",
"conveyed",
"within",
"the",
"context",
"of",
"South",
"African",
"families",
"on",
"an",
"everyday",
"basis.",
"Children",
"and",
"parents",
"in",
"18",
"families",
"from",
"a",
"range",
"of",
"different",
"material",
"and",
"cultural",
"backgrounds",
"were",
"interviewed",
"about",
"the",
"meanings",
"and",
"practices",
"of",
"gender",
"within",
"their",
"homes.",
"Data",
"were",
"analysed",
"using",
"a",
"Foucauldian",
"discourse",
"analysis.",
"The",
"data",
"reveal",
"how",
"problematic",
"constructions",
"of",
"masculinity",
"and",
"femininity",
"are",
"(re)",
"produced",
"but",
"also",
"challenged",
"within",
"a",
"range",
"of",
"different",
"families.",
"Gender",
"and",
"gender",
"(in)equality",
"are",
"therefore",
"routinely",
"accomplished",
"in",
"complex",
"ways.",
"These",
"findings",
"have",
"important",
"implications",
"for",
"promoting",
"gender",
"equality",
"and",
"therefore",
"for",
"disrupting",
"violence",
"and",
"sexual",
"risk",
"as",
"gendered",
"health",
"issues."
] | [
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[
"A",
"Support",
"Vector",
"Machine",
"Classification",
"of",
"Thyroid",
"Bioptic",
"Specimens",
"Using",
"MALDI-MSI",
"Data",
"Biomarkers",
"able",
"to",
"characterise",
"and",
"predict",
"multifactorial",
"diseases",
"are",
"still",
"one",
"of",
"the",
"most",
"important",
"targets",
"for",
"all",
"the",
"\"",
"omics",
"\"",
"investigations.",
"In",
"this",
"context,",
"Matrix-Assisted",
"Laser",
"Desorption/Ionisation-Mass",
"Spectrometry",
"Imaging",
"(MALDI-MSI)",
"has",
"gained",
"considerable",
"attention",
"in",
"recent",
"years,",
"but",
"it",
"also",
"led",
"to",
"a",
"huge",
"amount",
"of",
"complex",
"data",
"to",
"be",
"elaborated",
"and",
"interpreted.",
"For",
"this",
"reason,",
"computational",
"and",
"machine",
"learning",
"procedures",
"for",
"biomarker",
"discovery",
"are",
"important",
"tools",
"to",
"consider,",
"both",
"to",
"reduce",
"data",
"dimension",
"and",
"to",
"provide",
"predictive",
"markers",
"for",
"specific",
"diseases.",
"For",
"instance,",
"the",
"availability",
"of",
"protein",
"and",
"genetic",
"markers",
"to",
"support",
"thyroid",
"lesion",
"diagnoses",
"would",
"impact",
"deeply",
"on",
"society",
"due",
"to",
"the",
"high",
"presence",
"of",
"undetermined",
"reports",
"(THY3)",
"that",
"are",
"generally",
"treated",
"as",
"malignant",
"patients.",
"In",
"this",
"paper",
"we",
"show",
"how",
"an",
"accurate",
"classification",
"of",
"thyroid",
"bioptic",
"specimens",
"can",
"be",
"obtained",
"through",
"the",
"application",
"of",
"a",
"state-of-the-art",
"machine",
"learning",
"approach",
"(i.e.,",
"Support",
"Vector",
"Machines)",
"on",
"MALDI-MSI",
"data,",
"together",
"with",
"a",
"particular",
"wrapper",
"feature",
"selection",
"algorithm",
"(i.e.,",
"recursive",
"feature",
"elimination).",
"The",
"model",
"is",
"able",
"to",
"provide",
"an",
"accurate",
"discriminatory",
"capability",
"using",
"only",
"20",
"out",
"of",
"144",
"features,",
"resulting",
"in",
"an",
"increase",
"of",
"the",
"model",
"performances,",
"reliability,",
"and",
"computational",
"efficiency.",
"Finally,",
"tissue",
"areas",
"rather",
"than",
"average",
"proteomic",
"profiles",
"are",
"classified,",
"highlighting",
"potential",
"discriminating",
"areas",
"of",
"clinical",
"interest."
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[
"Conformers",
"of",
"Gaseous",
"Serine",
"The",
"myriad",
"conformers",
"of",
"the",
"neutral",
"form",
"of",
"natural",
"amino",
"acid",
"serine",
"(Ser)",
"have",
"been",
"investigated",
"by",
"systematic",
"computations",
"with",
"reliable",
"electronic",
"wave",
"function",
"methods.",
"A",
"total",
"of",
"85",
"unique",
"conformers",
"were",
"located",
"using",
"the",
"MP2/cc-pVTZ",
"level",
"of",
"theory.",
"The",
"12",
"lowest-energy",
"conformers",
"of",
"serine",
"fall",
"within",
"a",
"8",
"kJ",
"mol(-1)",
"window,",
"and",
"for",
"these",
"species,",
"geometric",
"structures,",
"precise",
"relative",
"energies,",
"equilibrium",
"and",
"vibrationally",
"averaged",
"rotational",
"constants,",
"anharmonic",
"vibrational",
"frequencies,",
"infrared",
"intensities,",
"quartic",
"and",
"sextic",
"centrifugal",
"distortion",
"constants,",
"dipole",
"moments,",
"and",
"(14)N",
"nuclear",
"quadrupole",
"coupling",
"constants",
"were",
"computed.",
"The",
"relative",
"energies",
"were",
"refined",
"through",
"composite",
"focal-point",
"analyses",
"employing",
"basis",
"sets",
"as",
"large",
"as",
"aug-cc-pV5Z",
"and",
"correlation",
"treatments",
"through",
"CCSD(T).",
"The",
"rotational",
"constants",
"for",
"seven",
"conformers",
"measured",
"by",
"Fourier-transform",
"microwave",
"spectroscopy",
"are",
"in",
"good",
"agreement",
"with",
"the",
"vibrationally",
"averaged",
"rotational",
"constants",
"computed",
"in",
"this",
"study.",
"Our",
"anharmonic",
"vibrational",
"frequencies",
"are",
"compared",
"to",
"the",
"large",
"number",
"of",
"experimental",
"vibrational",
"absorptions",
"attributable",
"to",
"at",
"least",
"six",
"conformers."
] | [
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[
"Interpretation",
"of",
"verbal",
"descriptors",
"for",
"response",
"options",
"commonly",
"used",
"in",
"verbal",
"rating",
"scales",
"in",
"patient",
"-reported",
"outcome",
"instruments",
"To",
"assess",
"the",
"variation",
"in",
"the",
"interpretation",
"of",
"common",
"verbal",
"descriptors",
"(VDs)",
"used",
"in",
"response",
"scales",
"and",
"examine",
"factors",
"associated",
"with",
"those",
"interpretations.",
"Subjects",
"were",
"recruited",
"through",
"MediGuard",
"and",
"they",
"assigned",
"interpretation",
"scores",
"(11-point",
"scale;",
"0",
"=",
"lowest",
"possible,",
"10",
"=",
"highest",
"possible)",
"to",
"five",
"common",
"sets",
"of",
"VDs:",
"set",
"one",
"(none,",
"mild,",
"moderate,",
"severe,",
"very",
"severe);",
"set",
"two",
"(never,",
"rarely,",
"sometimes,",
"often,",
"always);",
"set",
"three",
"(poor,",
"fair,",
"good,",
"very",
"good,",
"excellent);",
"set",
"four",
"(not",
"at",
"all,",
"a",
"little",
"bit,",
"moderately,",
"quite",
"a",
"bit,",
"extremely);",
"and",
"set",
"five",
"(not",
"at",
"all,",
"a",
"little",
"bit,",
"somewhat,",
"quite",
"a",
"bit,",
"very",
"much).",
"One-sample",
"test",
"for",
"proportions",
"and",
"T-tests",
"examined",
"equality",
"of",
"proportions",
"(anchors)",
"and",
"means",
"scores",
"(non-anchors)",
"with",
"the",
"fixed",
"intervals",
"(0.0,",
"2.5,",
"5.0,",
"7.5,",
"and",
"10.0).",
"Ordinal",
"regression",
"examined",
"adjusted",
"associations",
"between",
"demographic",
"/",
"clinical",
"factors",
"and",
"VD",
"scores.",
"Of",
"the",
"350",
"subjects,",
"68",
"%",
"were",
"females",
"and",
"mean",
"(SD)",
"age",
"was",
"56.9",
"(12.1).",
"Two",
"sets",
"had",
"two",
"VDs",
"with",
"mean",
"(95",
"%",
"CI)",
"scores",
"not",
"different",
"than",
"the",
"fixed",
"intervals.",
"Set",
"one",
"had",
"mild",
"=",
"2.50",
"(2.33;",
"2.66)",
"and",
"moderate",
"=",
"5.01",
"(4.89;",
"5.13)",
"with",
"98.8",
"%",
"(97.3",
"%;",
"100",
"%)",
"assigning",
"none",
"=",
"0.",
"Set",
"five",
"had",
"a",
"little",
"bit",
"=",
"2.35",
"(2.17;",
"2.53)",
"and",
"quite",
"a",
"bit",
"=",
"7.65",
"(7.43;",
"7.87)",
"with",
"95.0",
"%",
"(95",
"%",
"CI",
"91.7;",
"98.2)",
"assigning",
"not",
"at",
"all",
"=",
"0.",
"Significant",
"associations",
"(p",
"≤",
"0.05)",
"included",
"age",
"and",
"education",
"with",
"somewhat",
"and",
"income",
"and",
"comorbidities",
"with",
"very",
"severe.",
"Age,",
"sex,",
"and",
"education",
"showed",
"associations",
"with",
"other",
"VDs",
"albeit",
"in",
"nonsignificant",
"models.",
"Sets",
"one",
"and",
"five",
"yielded",
"data",
"closest",
"to",
"the",
"fixed",
"intervals.",
"Demographic",
"and",
"clinical",
"factors",
"are",
"associated",
"with",
"the",
"interpretation",
"of",
"some",
"VDs",
"and",
"should",
"be",
"adjusted",
"for",
"in",
"analyses",
"of",
"non-randomized",
"data."
] | [
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[
"Glycolysis",
"determines",
"dichotomous",
"regulation",
"of",
"T",
"cell",
"subsets",
"in",
"hypoxia",
"Hypoxia",
"occurs",
"in",
"many",
"pathological",
"conditions,",
"including",
"chronic",
"inflammation",
"and",
"tumors,",
"and",
"is",
"considered",
"to",
"be",
"an",
"inhibitor",
"of",
"T",
"cell",
"function.",
"However,",
"robust",
"T",
"cell",
"responses",
"occur",
"at",
"many",
"hypoxic",
"inflammatory",
"sites,",
"suggesting",
"that",
"functions",
"of",
"some",
"subsets",
"are",
"stimulated",
"under",
"low",
"oxygen",
"conditions.",
"Here,",
"we",
"investigated",
"how",
"hypoxic",
"conditions",
"influence",
"human",
"T",
"cell",
"functions",
"and",
"found",
"that,",
"in",
"contrast",
"to",
"naive",
"and",
"central",
"memory",
"T",
"cells",
"(TN",
"and",
"TCM),",
"hypoxia",
"enhances",
"the",
"proliferation,",
"viability,",
"and",
"cytotoxic",
"action",
"of",
"effector",
"memory",
"T",
"cells",
"(TEM).",
"Enhanced",
"TEM",
"expansion",
"in",
"hypoxia",
"corresponded",
"to",
"high",
"hypoxia-inducible",
"factor",
"1α",
"(HIF1α)",
"expression",
"and",
"glycolytic",
"activity",
"compared",
"with",
"that",
"observed",
"in",
"TN",
"and",
"TCM.",
"We",
"determined",
"that",
"the",
"glycolytic",
"enzyme",
"GAPDH",
"negatively",
"regulates",
"HIF1A",
"expression",
"by",
"binding",
"to",
"adenylate-uridylate-rich",
"elements",
"in",
"the",
"3'-UTR",
"region",
"of",
"HIF1A",
"mRNA",
"in",
"glycolytically",
"inactive",
"TN",
"and",
"TCM.",
"Conversely,",
"active",
"glycolysis",
"with",
"decreased",
"GAPDH",
"availability",
"in",
"TEM",
"resulted",
"in",
"elevated",
"HIF1α",
"expression.",
"Furthermore,",
"GAPDH",
"overexpression",
"reduced",
"HIF1α",
"expression",
"and",
"impaired",
"proliferation",
"and",
"survival",
"of",
"T",
"cells",
"in",
"hypoxia,",
"indicating",
"that",
"high",
"glycolytic",
"metabolism",
"drives",
"increases",
"in",
"HIF1α",
"to",
"enhance",
"TEM",
"function",
"during",
"hypoxia.",
"This",
"work",
"demonstrates",
"that",
"glycolytic",
"metabolism",
"regulates",
"the",
"translation",
"of",
"HIF1A",
"to",
"determine",
"T",
"cell",
"responses",
"to",
"hypoxia",
"and",
"implicates",
"GAPDH",
"as",
"a",
"potential",
"mechanism",
"for",
"controlling",
"T",
"cell",
"function",
"in",
"peripheral",
"tissue."
] | [
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[
"Nanocatalysts",
"promote",
"Streptococcus",
"mutans",
"biofilm",
"matrix",
"degradation",
"and",
"enhance",
"bacterial",
"killing",
"to",
"suppress",
"dental",
"caries",
"in",
"vivo",
"Dental",
"biofilms",
"(known",
"as",
"plaque)",
"are",
"notoriously",
"difficult",
"to",
"remove",
"or",
"treat",
"because",
"the",
"bacteria",
"can",
"be",
"enmeshed",
"in",
"a",
"protective",
"extracellular",
"matrix.",
"It",
"can",
"also",
"create",
"highly",
"acidic",
"microenvironments",
"that",
"cause",
"acid-dissolution",
"of",
"enamel",
"-",
"apatite",
"on",
"teeth,",
"leading",
"to",
"the",
"onset",
"of",
"dental",
"caries.",
"Current",
"antimicrobial",
"agents",
"are",
"incapable",
"of",
"disrupting",
"the",
"matrix",
"and",
"thereby",
"fail",
"to",
"efficiently",
"kill",
"the",
"microbes",
"within",
"plaque",
"-",
"biofilms.",
"Here,",
"we",
"report",
"a",
"novel",
"strategy",
"to",
"control",
"plaque",
"-",
"biofilms",
"using",
"catalytic",
"nanoparticles",
"(CAT-NP)",
"with",
"peroxidase",
"-like",
"activity",
"that",
"trigger",
"extracellular",
"matrix",
"degradation",
"and",
"cause",
"bacterial",
"death",
"within",
"acidic",
"niches",
"of",
"caries",
"-causing",
"biofilm.",
"CAT-NP",
"containing",
"biocompatible",
"Fe3O4",
"were",
"developed",
"to",
"catalyze",
"H2O2",
"to",
"generate",
"free-radicals",
"in",
"situ",
"that",
"simultaneously",
"degrade",
"the",
"biofilm",
"matrix",
"and",
"rapidly",
"kill",
"the",
"embedded",
"bacteria",
"with",
"exceptional",
"efficacy",
"(>5-log",
"reduction",
"of",
"cell-viability).",
"Moreover,",
"it",
"displays",
"an",
"additional",
"property",
"of",
"reducing",
"apatite",
"demineralization",
"in",
"acidic",
"conditions.",
"Using",
"1-min",
"topical",
"daily",
"treatments",
"akin",
"to",
"a",
"clinical",
"situation,",
"we",
"demonstrate",
"that",
"CAT-NP",
"in",
"combination",
"with",
"H2O2",
"effectively",
"suppress",
"the",
"onset",
"and",
"severity",
"of",
"dental",
"caries",
"while",
"sparing",
"normal",
"tissues",
"in",
"vivo.",
"Our",
"results",
"reveal",
"the",
"potential",
"to",
"exploit",
"nanocatalysts",
"with",
"enzyme-like",
"activity",
"as",
"a",
"potent",
"alternative",
"approach",
"for",
"treatment",
"of",
"a",
"prevalent",
"biofilm",
"-associated",
"oral",
"disease."
] | [
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[
"N-linked",
"glycosylation",
"of",
"SV2",
"is",
"required",
"for",
"binding",
"and",
"uptake",
"of",
"botulinum",
"neurotoxin",
"A",
"Botulinum",
"neurotoxin",
"serotype",
"A1",
"(BoNT/A1),",
"a",
"licensed",
"drug",
"widely",
"used",
"for",
"medical",
"and",
"cosmetic",
"applications,",
"exerts",
"its",
"action",
"by",
"invading",
"motoneurons.",
"Here",
"we",
"report",
"a",
"2.0-Å-resolution",
"crystal",
"structure",
"of",
"the",
"BoNT/A1",
"receptor",
"-",
"binding",
"domain",
"in",
"complex",
"with",
"its",
"neuronal",
"receptor,",
"glycosylated",
"human",
"SV2C.",
"We",
"found",
"that",
"the",
"neuronal",
"tropism",
"of",
"BoNT/A1",
"requires",
"recognition",
"of",
"both",
"the",
"peptide",
"moiety",
"and",
"an",
"N-linked",
"glycan",
"on",
"SV2.",
"This",
"N-glycan",
"-which",
"is",
"conserved",
"in",
"all",
"SV2",
"isoforms",
"across",
"vertebrates",
"-is",
"essential",
"for",
"BoNT/A1",
"binding",
"to",
"neurons",
"and",
"for",
"its",
"potent",
"neurotoxicity.",
"The",
"glycan",
"-",
"binding",
"interface",
"on",
"SV2",
"is",
"targeted",
"by",
"a",
"human",
"BoNT/A1",
"-",
"neutralizing",
"antibody",
"currently",
"licensed",
"as",
"an",
"antibotulism",
"drug.",
"Our",
"studies",
"reveal",
"a",
"new",
"paradigm",
"of",
"host-pathogen",
"interactions,",
"in",
"which",
"pathogens",
"exploit",
"conserved",
"host",
"post-translational",
"modifications,",
"thereby",
"achieving",
"highly",
"specific",
"receptor",
"binding",
"while",
"also",
"tolerating",
"genetic",
"changes",
"across",
"multiple",
"isoforms",
"of",
"receptors."
] | [
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[
"Accuracy",
"of",
"Currently",
"Used",
"Paper",
"Burn",
"Diagram",
"vs",
"a",
"Three-Dimensional",
"Computerized",
"Model",
"Burn",
"units",
"have",
"historically",
"used",
"paper",
"diagrams",
"to",
"estimate",
"percent",
"burn;",
"however,",
"unintentional",
"errors",
"can",
"occur.",
"The",
"use",
"of",
"a",
"computer",
"program",
"that",
"incorporates",
"wound",
"mapping",
"from",
"photographs",
"onto",
"a",
"three-dimensional",
"(3D)",
"human",
"diagram",
"could",
"decrease",
"subjectivity",
"in",
"preparing",
"burn",
"diagrams",
"and",
"subsequent",
"calculations",
"of",
"TBSA",
"burned.",
"Analyses",
"were",
"done",
"on",
"19",
"burned",
"patients",
"who",
"had",
"an",
"estimated",
"TBSA",
"burned",
"of",
"≥20%.",
"The",
"patients",
"were",
"admitted",
"to",
"Shriners",
"Hospitals",
"for",
"Children",
"or",
"the",
"University",
"of",
"Texas",
"Medical",
"Branch",
"in",
"Galveston,",
"Texas,",
"from",
"July",
"2012",
"to",
"September",
"2013",
"for",
"treatment.",
"Digital",
"photographs",
"were",
"collected",
"before",
"the",
"patient's",
"first",
"surgery.",
"Using",
"BurnCase",
"3D",
"(RISC",
"Software",
"GmbH,",
"Hagenberg,",
"Austria),",
"a",
"burn",
"mapping",
"software,",
"the",
"user",
"traced",
"partial-",
"and",
"full-thickness",
"burns",
"from",
"photographs.",
"The",
"program",
"then",
"superimposed",
"tracings",
"onto",
"a",
"3D",
"model",
"and",
"calculated",
"percent",
"burned.",
"The",
"results",
"were",
"compared",
"with",
"the",
"Lund",
"and",
"Browder",
"diagrams",
"completed",
"after",
"the",
"first",
"operation.",
"A",
"two-tailed",
"t-test",
"was",
"used",
"to",
"calculate",
"statistical",
"differences.",
"For",
"partial-thickness",
"burns,",
"burn",
"sizes",
"calculated",
"using",
"Lund",
"and",
"Browder",
"diagrams",
"were",
"significantly",
"larger",
"than",
"those",
"calculated",
"using",
"BurnCase",
"3D",
"(15%",
"difference,",
"P",
"<",
".01).",
"The",
"opposite",
"was",
"found",
"for",
"full-thickness",
"burns,",
"with",
"burn",
"sizes",
"being",
"smaller",
"when",
"calculated",
"using",
"Lund",
"and",
"Browder",
"diagrams",
"(11%",
"difference,",
"P",
"<",
".05).",
"In",
"conclusion,",
"substantial",
"differences",
"exist",
"in",
"percent",
"burn",
"estimations",
"derived",
"from",
"BurnCase",
"3D",
"and",
"paper",
"diagram",
"s.",
"In",
"our",
"studied",
"cohort,",
"paper",
"diagram",
"s",
"were",
"associated",
"with",
"overestimation",
"of",
"partial-thickness",
"burn",
"size",
"and",
"underestimation",
"of",
"full-thickness",
"burn",
"size.",
"Additional",
"studies",
"comparing",
"BurnCase",
"3D",
"with",
"other",
"commonly",
"used",
"methods",
"are",
"warranted."
] | [
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[
"Field",
"Measurements",
"and",
"Numerical",
"Simulations",
"of",
"Temperature",
"and",
"Moisture",
"in",
"Highway",
"Engineering",
"Using",
"a",
"Frequency",
"Domain",
"Reflectometry",
"Sensor",
"This",
"paper",
"presents",
"a",
"systematic",
"pioneering",
"study",
"on",
"the",
"use",
"of",
"agricultural",
"-",
"purpose",
"frequency",
"domain",
"reflectometry",
"(FDR)",
"sensors",
"to",
"monitor",
"temperature",
"and",
"moisture",
"of",
"a",
"subgrade",
"in",
"highway",
"extension",
"and",
"reconstruction",
"engineering.",
"The",
"principle",
"of",
"agricultural",
"-",
"purpose",
"FDR",
"sensors",
"and",
"the",
"process",
"for",
"embedding",
"this",
"kind",
"of",
"sensors",
"for",
"subgrade",
"engineering",
"purposes",
"are",
"introduced.",
"Based",
"on",
"field",
"measured",
"weather",
"data,",
"a",
"numerical",
"analysis",
"model",
"for",
"temperature",
"and",
"moisture",
"content",
"in",
"the",
"subgrade's",
"soil",
"is",
"built.",
"Comparisons",
"of",
"the",
"temperature",
"and",
"moisture",
"data",
"obtained",
"from",
"numerical",
"simulation",
"and",
"FDR",
"-based",
"measurements",
"are",
"conducted.",
"The",
"results",
"show",
"that:",
"(1)",
"the",
"embedding",
"method",
"and",
"process,",
"data",
"acquisition,",
"and",
"remote",
"transmission",
"presented",
"are",
"reasonable;",
"(2)",
"the",
"temperature",
"and",
"moisture",
"changes",
"are",
"coordinated",
"with",
"the",
"atmospheric",
"environment",
"and",
"they",
"are",
"also",
"in",
"close",
"agreement",
"with",
"numerical",
"calculations;",
"(3)",
"the",
"change",
"laws",
"of",
"both",
"are",
"consistent",
"at",
"positions",
"where",
"the",
"subgrade",
"is",
"compacted",
"uniformly.",
"These",
"results",
"suggest",
"that",
"the",
"data",
"measured",
"by",
"the",
"agricultural",
"-",
"purpose",
"FDR",
"sensors",
"are",
"reliable.",
"The",
"findings",
"of",
"this",
"paper",
"enable",
"a",
"new",
"and",
"effective",
"real-time",
"monitoring",
"method",
"for",
"a",
"subgrade's",
"temperature",
"and",
"moisture",
"changes,",
"and",
"thus",
"broaden",
"the",
"application",
"of",
"agricultural",
"-",
"purpose",
"FDR",
"sensors."
] | [
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[
"Smart",
"Thin",
"Hydrogel",
"Coatings",
"Harnessing",
"Hydrophobicity",
"and",
"Topography",
"to",
"Capture",
"and",
"Release",
"Cancer",
"Cells",
"Smart",
"thin",
"hydrogel",
"coatings",
"are",
"fabricated",
"to",
"capture",
"and",
"release",
"targeted",
"cancer",
"cells",
"by",
"simultaneously",
"tuning",
"surface",
"hydrophobicity",
"and",
"topography.",
"At",
"physiological",
"temperature,",
"the",
"targeted",
"cancer",
"cells",
"are",
"capture",
"d",
"on",
"the",
"hydrophobic",
"and",
"wrinkled",
"coating",
"surface.",
"At",
"room",
"temperature,",
"the",
"captured",
"cells",
"are",
"released",
"from",
"the",
"hydrophilic",
"and",
"smooth",
"coating",
"surface."
] | [
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[
"Parametric",
"Surface",
"Diffeomorphometry",
"for",
"Low",
"Dimensional",
"Embeddings",
"of",
"Dense",
"Segmentations",
"and",
"Imagery",
"In",
"the",
"field",
"of",
"Computational",
"Anatomy,",
"biological",
"form",
"(including",
"our",
"focus,",
"neuroanatomy)",
"is",
"studied",
"quantitatively",
"through",
"the",
"action",
"of",
"the",
"diffeomorphism",
"group",
"on",
"example",
"anatomies",
"-",
"a",
"technique",
"called",
"diffeomorphometry.",
"Here",
"we",
"design",
"an",
"algorithm",
"within",
"this",
"framework",
"to",
"pass",
"from",
"dense",
"objects",
"common",
"in",
"neuromaging",
"studies",
"(binary",
"segmentations,",
"structural",
"images)",
"to",
"a",
"sparse",
"representation",
"defined",
"on",
"the",
"surface",
"boundaries",
"of",
"anatomical",
"structures,",
"and",
"embedded",
"into",
"the",
"low",
"dimensional",
"coordinates",
"of",
"a",
"parametric",
"model.",
"Our",
"main",
"new",
"contribution",
"is",
"to",
"introduce",
"an",
"expanded",
"group",
"action",
"to",
"simultaneously",
"deform",
"surfaces",
"through",
"direct",
"mapping",
"of",
"points,",
"as",
"well",
"as",
"images",
"through",
"functional",
"composition",
"with",
"the",
"inverse.",
"This",
"allows",
"us",
"to",
"index",
"the",
"diffeomorphisms",
"with",
"respect",
"to",
"two-dimensional",
"surface",
"geometries",
"like",
"subcortical",
"gray",
"matter",
"structures,",
"but",
"explicitly",
"map",
"onto",
"cost",
"functions",
"determined",
"by",
"noisy",
"3-dimensional",
"measurements.",
"We",
"consider",
"models",
"generated",
"from",
"empirical",
"covariance",
"of",
"training",
"data,",
"as",
"well",
"as",
"bandlimited",
"(Laplace-Beltrami",
"eigenfunction)",
"models",
"when",
"no",
"such",
"data",
"is",
"available.",
"We",
"show",
"applications",
"to",
"noisy",
"or",
"anomalous",
"segmentations,",
"and",
"other",
"typical",
"problems",
"in",
"neuroimaging",
"studies.",
"We",
"reproduce",
"statistical",
"results",
"detecting",
"changes",
"in",
"Alzheimer's",
"disease,",
"despite",
"dimensionality",
"reduction.",
"Lastly",
"we",
"apply",
"our",
"algorithm",
"to",
"the",
"common",
"problem",
"of",
"segmenting",
"subcortical",
"structures",
"from",
"T1",
"MR",
"images."
] | [
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[
"Fathers'",
"Roles",
"in",
"the",
"Care",
"and",
"Development",
"of",
"Their",
"Children:",
"The",
"Role",
"of",
"Pediatricians",
"Fathers'",
"involvement",
"in",
"and",
"influence",
"on",
"the",
"health",
"and",
"development",
"of",
"their",
"children",
"have",
"increased",
"in",
"a",
"myriad",
"of",
"ways",
"in",
"the",
"past",
"10",
"years",
"and",
"have",
"been",
"widely",
"studied.",
"The",
"role",
"of",
"pediatricians",
"in",
"working",
"with",
"fathers",
"has",
"correspondingly",
"increased",
"in",
"importance.",
"This",
"report",
"reviews",
"new",
"studies",
"of",
"the",
"epidemiology",
"of",
"father",
"involvement,",
"including",
"nonresidential",
"as",
"well",
"as",
"residential",
"fathers.",
"The",
"effects",
"of",
"father",
"involvement",
"on",
"child",
"outcomes",
"are",
"discussed",
"within",
"each",
"phase",
"of",
"a",
"child's",
"development.",
"Particular",
"emphasis",
"is",
"placed",
"on",
"(1)",
"fathers'",
"involvement",
"across",
"childhood",
"ages",
"and",
"(2)",
"the",
"influence",
"of",
"fathers'",
"physical",
"and",
"mental",
"health",
"on",
"their",
"children.",
"Implications",
"and",
"advice",
"for",
"all",
"child",
"health",
"providers",
"to",
"encourage",
"and",
"support",
"father",
"involvement",
"are",
"outlined."
] | [
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[
"Prediction",
"of",
"Clinically",
"Significant",
"Bleeding",
"Following",
"Wide-Field",
"Endoscopic",
"Resection",
"of",
"Large",
"Sessile",
"and",
"Laterally",
"Spreading",
"Colorectal",
"Lesions:",
"A",
"Clinical",
"Risk",
"Score",
"Clinically",
"significant",
"bleeding",
"(CSPEB)",
"is",
"the",
"most",
"frequent",
"adverse",
"event",
"following",
"wide-field",
"endoscopic",
"mucosal",
"resection",
"(WF-EMR)",
"of",
"large",
"sessile",
"and",
"laterally",
"spreading",
"colorectal",
"lesions",
"(LSL).",
"There",
"is",
"limited",
"knowledge",
"regarding",
"accurate",
"prediction",
"of",
"CSPEB.",
"We",
"aimed",
"to",
"derive",
"a",
"score",
"to",
"predict",
"the",
"risk",
"of",
"CSPEB.",
"Data",
"on",
"patient",
"and",
"lesion",
"characteristics",
"and",
"outcomes",
"from",
"WF-EMRs",
"of",
"LSL",
"≥20",
"mm",
"at",
"8",
"referral",
"hospitals",
"were",
"analyzed.",
"The",
"cohort",
"was",
"divided",
"at",
"random",
"into",
"equal",
"sized",
"training",
"and",
"test",
"groups.",
"Independent",
"predictors",
"of",
"CSPEB",
"in",
"the",
"training",
"cohort",
"were",
"identified",
"by",
"multiple",
"logistic",
"regression",
"analysis",
"and",
"used",
"to",
"develop",
"a",
"risk",
"score.",
"The",
"performance",
"of",
"this",
"score",
"was",
"assessed",
"in",
"the",
"independent",
"test",
"cohort.",
"Over",
"80",
"months",
"to",
"June",
"2015,",
"2,128",
"patients",
"with",
"2,424",
"LSL",
"were",
"referred",
"for",
"WF-EMR.",
"Two",
"thousand",
"and",
"twelve",
"patients",
"were",
"eligible",
"for",
"analysis.",
"There",
"were",
"135",
"cases",
"of",
"CSPEB",
"(6.7%).",
"In",
"the",
"training",
"cohort",
"of",
"1,006",
"patients,",
"the",
"independent",
"predictors",
"of",
"CSPEB",
"were",
"lesion",
"size",
">30",
"mm",
"(odds",
"ratio",
"(OR)",
"2.5),",
"proximal",
"colonic",
"location",
"(OR",
"2.3),",
"presence",
"of",
"a",
"major",
"comorbidity",
"(OR",
"1.5),",
"and",
"epinephrine",
"in",
"injection",
"solution",
"(OR",
"0.57).",
"The",
"derived",
"risk",
"score",
"comprised",
"lesion",
"size",
">30",
"mm",
"(2",
"points),",
"proximal",
"colon",
"(2",
"points),",
"presence",
"of",
"major",
"comorbidity",
"(1",
"point),",
"and",
"absence",
"of",
"epinephrine",
"use",
"(1",
"point).",
"The",
"probabilities",
"of",
"CSPEB",
"for",
"scores",
"of",
"0,",
"1,",
"2,",
"3,",
"4,",
"and",
"≥5",
"in",
"the",
"training",
"cohort",
"were",
"1.5,",
"2.0,",
"5.6,",
"7.8,",
"9.1,",
"and",
"17.5%",
"and",
"were",
"0.9,",
"6.7,",
"4.9,",
"6.2,",
"9.0,",
"and",
"15.7%",
"in",
"the",
"test",
"cohort.",
"The",
"probabilities",
"of",
"CSPEB",
"in",
"those",
"with",
"low",
"(score",
"0-1),",
"medium",
"(score",
"2-4),",
"and",
"elevated",
"(score",
"5-6)",
"risk",
"levels",
"were",
"1.7,",
"7.1,",
"and",
"17.5%",
"in",
"the",
"training",
"cohort",
"and",
"3.4,",
"6.2,",
"and",
"15.7%",
"in",
"the",
"cohort.",
"Patients",
"at",
"elevated",
"risk",
"of",
"CSPEB",
"can",
"be",
"identified",
"using",
"four",
"readily",
"available",
"variables.",
"This",
"knowledge",
"may",
"improve",
"the",
"management",
"of",
"those",
"undergoing",
"WF-EMR",
"and",
"assist",
"in",
"designing",
"studies",
"evaluating",
"CSPEB."
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[
"Therapeutic",
"Review",
"of",
"Methylprednisolone",
"Acetate",
"Intra-Articular",
"Injection",
"in",
"the",
"Management",
"of",
"Osteoarthritis",
"of",
"the",
"Knee",
"-",
"Part",
"1:",
"Clinical",
"Effectiveness",
"Intra-articular",
"(IA)",
"corticosteroid",
"injections",
"are",
"a",
"common",
"approach",
"in",
"the",
"management",
"of",
"osteoarthritis",
"(OA)",
"of",
"the",
"knee.",
"The",
"effectiveness",
"of",
"injections",
"and",
"particular",
"injection",
"products",
"is",
"often",
"discussed",
"and",
"debated",
"in",
"clinical",
"arenas.",
"The",
"following",
"therapeutic",
"review",
"examines",
"the",
"evidence",
"for",
"intra-articular",
"methylprednisolone",
"acetate",
"(MPA)",
"injections",
"in",
"the",
"management",
"of",
"OA",
"knee.",
"A",
"review",
"of",
"research",
"evidence,",
"published",
"guidelines",
"and",
"clinical",
"literature",
"was",
"undertaken",
"following",
"an",
"electronic",
"database",
"and",
"relevant",
"literature",
"search.",
"The",
"review",
"found",
"that",
"there",
"is",
"limited",
"evidence",
"which",
"indicates",
"that",
"a",
"single",
"dose",
"intra-articular",
"MPA",
"injection",
"can",
"provide",
"short",
"to",
"medium",
"term",
"benefits",
"for",
"pain,",
"with",
"less",
"evidence",
"for",
"beneficial",
"effects",
"on",
"function",
"or",
"stiffness.",
"There",
"is",
"heterogeneity",
"across",
"studies",
"and",
"until",
"recently,",
"most",
"studies",
"had",
"only",
"short",
"to",
"medium",
"term",
"follow-up",
"periods,",
"thus",
"limiting",
"the",
"evidence",
"available",
"on",
"longer",
"term",
"benefit.",
"There",
"was",
"also",
"evidence",
"indicating",
"equivalent",
"overall",
"efficacy",
"of",
"MPA",
"to",
"that",
"of",
"other",
"corticosteroid",
"products.",
"Most",
"guideline",
"recommendations",
"concerning",
"IA",
"injections",
"for",
"OA",
"knee",
"have",
"drawn",
"on",
"evidence",
"from",
"pooled",
"data",
"for",
"several",
"corticosteroid",
"products.",
"The",
"review",
"also",
"found",
"there",
"was",
"limited",
"reporting",
"of",
"the",
"incidence",
"of",
"adverse",
"events",
"in",
"most",
"studies.",
"Overall,",
"MPA",
"shows",
"efficacy",
"for",
"symptom",
"relief",
"in",
"OA",
"knee.",
"At",
"an",
"individual",
"management",
"level,",
"evidence",
"for",
"a",
"limited",
"duration",
"of",
"effect",
"needs",
"consideration",
"in",
"injections",
"decisions.",
"Furthermore,",
"consensus",
"across",
"clinical",
"guidelines",
"suggests",
"that",
"the",
"management",
"of",
"OA",
"knee",
"should",
"be",
"individualized",
"to",
"a",
"person",
"'s",
"clinical",
"history,",
"degree",
"of",
"disability,",
"risk",
"factors,",
"quality",
"of",
"life",
"and",
"personal",
"preferences,",
"whereby",
"injecting",
"involves",
"a",
"shared",
"decision",
"and",
"forms",
"part",
"of",
"a",
"multimodal",
"approach.",
"Copyright",
"©",
"2016",
"John",
"Wiley",
"&",
"Sons",
"Ltd."
] | [
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0,
1,
0,
1,
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1,
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1,
1,
2,
1,
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2,
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1,
2,
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[
"Twelve",
"ways",
"to",
"confirm",
"targets",
"of",
"activity-based",
"probes",
"in",
"plants",
"Activity-based",
"probes",
"are",
"powerful",
"tools",
"to",
"interrogate",
"the",
"functional",
"proteome.",
"Their",
"covalent",
"and",
"often",
"irreversible",
"labeling",
"of",
"proteins",
"facilitates",
"the",
"purification,",
"identification",
"and",
"quantification",
"of",
"labeled",
"proteins.",
"However,",
"the",
"detection",
"of",
"labeled",
"proteins",
"often",
"requires",
"a",
"confirmation,",
"especially",
"when",
"unexpected",
"proteins",
"are",
"identified,",
"or",
"to",
"unravel",
"fluorescent",
"activity",
"profiles.",
"Here,",
"we",
"review",
"twelve",
"approaches",
"towards",
"target",
"confirmation,",
"grouped",
"in",
"approaches",
"by",
"direct",
"target",
"detection,",
"target",
"expression",
"or",
"target",
"depletion.",
"We",
"discuss",
"their",
"proper",
"use",
"and",
"limitations",
"and",
"illustrate",
"these",
"approaches",
"with",
"examples",
"from",
"plant",
"science."
] | [
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[
"Common",
"and",
"Uncommon",
"Anatomical",
"Variants",
"of",
"Intrahepatic",
"Bile",
"Ducts",
"in",
"Magnetic",
"Resonance",
"Cholangiopancreatography",
"and",
"its",
"Clinical",
"Implication",
"Preoperative",
"knowledge",
"of",
"intrahepatic",
"bile",
"duct",
"(IHD)",
"anatomy",
"is",
"critical",
"for",
"planning",
"liver",
"resections,",
"liver",
"transplantations",
"and",
"complex",
"biliary",
"reconstructive",
"surgery.",
"The",
"purpose",
"of",
"our",
"study",
"was",
"to",
"demonstrate",
"the",
"imaging",
"features",
"of",
"various",
"anatomical",
"variants",
"of",
"IHD",
"using",
"magnetic",
"resonance",
"cholangio-pancreatography",
"(MRCP)",
"and",
"their",
"prevalence",
"in",
"our",
"population.",
"This",
"observational",
"clinical",
"evaluation",
"study",
"included",
"224",
"patients",
"who",
"were",
"referred",
"for",
"MRCP.",
"MRCP",
"was",
"performed",
"in",
"a",
"1.5-Tesla",
"magnet",
"(Philips)",
"with",
"SSH",
"MRCP",
"3DHR",
"and",
"SSHMRCP",
"rad",
"protocol.",
"A",
"senior",
"radiologist",
"assessed",
"the",
"biliary",
"passage",
"for",
"anatomical",
"variations.",
"The",
"branching",
"pattern",
"of",
"the",
"right",
"hepatic",
"duct",
"(RHD)",
"was",
"typical",
"in",
"55.3%",
"of",
"subjects.",
"The",
"most",
"common",
"variant",
"was",
"right",
"posterior",
"sectoral",
"duct",
"(RPSD)",
"draining",
"into",
"the",
"left",
"hepatic",
"duct",
"(LHD)",
"in",
"27.6%",
"of",
"subjects.",
"Trifurcation",
"pattern",
"was",
"noted",
"in",
"9.3%",
"of",
"subjects.",
"In",
"4%",
"of",
"subjects,",
"RPSD",
"was",
"draining",
"into",
"the",
"common",
"hepatic",
"duct",
"(CHD)",
"and",
"in",
"0.8%",
"of",
"subjects",
"into",
"the",
"cystic",
"duct.",
"Other",
"variants",
"were",
"noted",
"in",
"2.6%",
"of",
"subjects.",
"In",
"4.9%",
"of",
"cases",
"there",
"was",
"an",
"accessory",
"duct.",
"The",
"most",
"common",
"type",
"of",
"LHD",
"branching",
"pattern",
"was",
"a",
"common",
"trunk",
"of",
"segment",
"2",
"and",
"3",
"ducts",
"joining",
"the",
"segment",
"4",
"duct",
"in",
"67.8%",
"of",
"subjects.",
"In",
"23.2%",
"of",
"subjects,",
"segment",
"2",
"duct",
"united",
"with",
"the",
"common",
"trunk",
"of",
"segment",
"3",
"and",
"4",
"and",
"in",
"3.4%",
"of",
"subjects",
"segment",
"2,",
"3,",
"and",
"4",
"ducts",
"united",
"together",
"to",
"form",
"LHD.",
"Other",
"uncommon",
"branching",
"patterns",
"of",
"LHD",
"were",
"seen",
"in",
"4.9%",
"of",
"subjects.",
"Intrahepatic",
"bile",
"duct",
"anatomy",
"is",
"complex",
"with",
"many",
"common",
"and",
"uncommon",
"variations.",
"MRCP",
"is",
"a",
"reliable",
"non-invasive",
"imaging",
"method",
"for",
"demonstration",
"of",
"bile",
"duct",
"morpholog",
"y,",
"which",
"is",
"useful",
"to",
"plan",
"complex",
"surgeries",
"and",
"to",
"prevent",
"iatrogenic",
"injuries."
] | [
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[
"Cortical",
"Reorganization",
"following",
"Injury",
"Early",
"in",
"Life",
"The",
"brain",
"has",
"a",
"remarkable",
"capacity",
"for",
"reorganization",
"following",
"injury,",
"especially",
"during",
"the",
"first",
"years",
"of",
"life.",
"Knowledge",
"of",
"structural",
"reorganization",
"and",
"its",
"consequences",
"following",
"perinatal",
"injury",
"is",
"sparse.",
"Here",
"we",
"studied",
"changes",
"in",
"brain",
"tissue",
"volume,",
"morphology,",
"perfusion,",
"and",
"integrity",
"in",
"children",
"with",
"hemiplegia",
"compared",
"to",
"typically",
"developing",
"children,",
"using",
"MRI.",
"Children",
"with",
"hemiplegia",
"demonstrated",
"reduced",
"total",
"cerebral",
"volume,",
"with",
"increased",
"cerebrospinal",
"fluid",
"(CSF)",
"and",
"reduced",
"total",
"white",
"matter",
"volumes,",
"with",
"no",
"differences",
"in",
"total",
"gray",
"matter",
"volume,",
"compared",
"to",
"typically",
"developing",
"children.",
"An",
"increase",
"in",
"cortical",
"thickness",
"at",
"the",
"hemisphere",
"contralateral",
"to",
"the",
"lesion",
"(CLH)",
"was",
"detected",
"in",
"motor",
"and",
"language",
"areas,",
"which",
"may",
"reflect",
"compensation",
"for",
"the",
"gray",
"matter",
"loss",
"in",
"the",
"lesion",
"area",
"or",
"retention",
"of",
"ipsilateral",
"pathways.",
"In",
"addition,",
"reduced",
"cortical",
"thickness,",
"perfusion,",
"and",
"surface",
"area",
"were",
"detected",
"in",
"limbic",
"areas.",
"Increased",
"CSF",
"volume",
"and",
"precentral",
"cortical",
"thickness",
"and",
"reduced",
"white",
"matter",
"volume",
"were",
"correlated",
"with",
"worse",
"motor",
"performance.",
"Brain",
"reorganization",
"of",
"the",
"gray",
"matter",
"within",
"the",
"CLH,",
"while",
"not",
"necessarily",
"indicating",
"better",
"outcome,",
"is",
"suggested",
"as",
"a",
"response",
"to",
"neuronal",
"deficits",
"following",
"injury",
"early",
"in",
"life."
] | [
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[
"Simultaneous",
"Bilateral",
"Femur",
"Neck",
"Fracture",
"in",
"A",
"Young",
"Adult",
"with",
"Chronic",
"Renal",
"Failure",
"-",
"A",
"Case",
"Report",
"and",
"Review",
"of",
"Literature",
"Pathological",
"bilateral",
"femoral",
"neck",
"fracture",
"due",
"to",
"renal",
"osteodystrophy",
"is",
"rare.",
"This",
"is",
"a",
"report",
"of",
"a",
"chronic",
"renal",
"failure",
"patient",
"who",
"had",
"sustained",
"bilateral",
"intra-capsular",
"displaced",
"fracture",
"neck",
"of",
"femur",
"following",
"an",
"episode",
"of",
"convulsion",
"and",
"the",
"difficulties",
"encountered",
"in",
"early",
"diagnosis",
"and",
"treatment.",
"The",
"pathophysiology",
"of",
"renal",
"osteodystrophy",
"and",
"the",
"treatment",
"of",
"hip",
"fractures",
"in",
"patients",
"with",
"renal",
"failure",
"are",
"also",
"discussed.",
"A",
"23",
"years",
"old",
"male",
"patient",
"admitted",
"with",
"h/o",
"dysuria,",
"pyuria",
"and",
"loss",
"of",
"appetite",
"since",
"3",
"months.",
"He",
"was",
"a",
"known",
"case",
"of",
"chronic",
"renal",
"failure",
"and",
"reflux",
"nephropathy.",
"On",
"investigating,",
"patient's",
"renal",
"parameters",
"were",
"high",
"and",
"he",
"was",
"started",
"with",
"haemodialysis.",
"The",
"next",
"day",
"patient",
"had",
"c/o",
"bilateral",
"hip",
"pain",
"and",
"inability",
"to",
"move",
"bilateral",
"lower",
"limbs",
"following",
"an",
"episode",
"of",
"seizure.",
"Radiograph",
"of",
"pelvis",
"showed",
"vertical",
"sub",
"capital",
"fractures",
"of",
"bilateral",
"neck",
"of",
"femur.",
"In",
"this",
"patient,",
"considering",
"his",
"age,",
"general",
"condition",
"&",
"prognosis,",
"an",
"elective",
"surgery",
"in",
"the",
"form",
"of",
"bilateral",
"uncemented",
"modular",
"bipolar",
"hemiarthroplasty",
"was",
"done.",
"Overall",
"risk",
"of",
"hip",
"fracture",
"among",
"patients",
"with",
"chronic",
"renal",
"failure",
"is",
"considerably",
"higher",
"than",
"in",
"the",
"general",
"population,",
"independent",
"of",
"age",
"and",
"gender.",
"Simultaneous",
"spontaneous",
"bilateral",
"fractures",
"of",
"the",
"femoral",
"neck",
"are",
"rare",
"and",
"a",
"delayed",
"diagnosis",
"is",
"usual.",
"The",
"study",
"of",
"etiological",
"factors",
"of",
"these",
"fractures",
"is",
"essential",
"to",
"guide",
"us",
"in",
"choosing",
"the",
"treatment",
"of",
"choice.",
"Obviously",
"patient's",
"age,",
"life",
"expectancy",
"as",
"well",
"as",
"renal",
"co",
"morbidity",
"has",
"an",
"influence",
"over",
"deciding",
"treatment",
"and",
"outcome."
] | [
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1,
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1,
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[
"Anti-inflammatory",
"and",
"antimicrobial",
"coumarins",
"from",
"the",
"stems",
"of",
"Eurya",
"chinensis",
"Two",
"new",
"coumarins,",
"named",
"(±)-euryacoumarin",
"A",
"(1)",
"and",
"6-demethylobtusinin",
"(2),",
"and",
"one",
"new",
"natural",
"coumarin,",
"named",
"euryacoumarin",
"B",
"(3),",
"along",
"with",
"two",
"known",
"compounds,",
"scopoletin",
"(4)",
"and",
"obtusinol",
"(5),",
"were",
"isolated",
"from",
"the",
"stems",
"of",
"Eurya",
"chinensis.",
"Their",
"structures",
"were",
"elucidated",
"by",
"means",
"of",
"extensive",
"spectroscopic",
"methods",
"and",
"comparison",
"with",
"data",
"reported",
"in",
"the",
"literatures.",
"Compound",
"1",
"exhibited",
"significant",
"inhibition",
"of",
"LPS-induced",
"nitric",
"oxide",
"(NO)",
"production",
"in",
"RAW264.7",
"cells",
"with",
"IC50",
"value",
"of",
"35.64",
"±",
"1.73",
"μM,",
"and",
"showed",
"marginal",
"antibacterial",
"activities",
"against",
"Bacillus",
"subtilis",
"and",
"B.",
"cereus",
"with",
"MIC",
"values",
"of",
"50.59",
"±",
"2.12",
"and",
"35.42",
"±",
"0.96",
"μM,",
"respectively."
] | [
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[
"Extrapulmonary",
"Small",
"Cell",
"Carcinoma",
"of",
"the",
"Seminal",
"Vesicles",
"and",
"Prostate",
"Demonstrated",
"on",
"18F-FDG",
"Positron",
"Emission",
"Tomography/Computed",
"Tomography",
"Extrapulmonary",
"primary",
"small",
"cell",
"carcinomas",
"arising",
"from",
"the",
"urogenital",
"tract",
"is",
"infrequent.",
"It",
"can",
"rarely",
"arise",
"from",
"the",
"prostate",
"and",
"even",
"more",
"rarely",
"from",
"the",
"seminal",
"vesicles.",
"We",
"present",
"a",
"79-",
"year",
"-old",
"male",
"who",
"was",
"admitted",
"due",
"to",
"acute",
"renal",
"failure",
"with",
"a",
"history",
"of",
"radical",
"radiotherapy",
"for",
"prostate",
"adenocarcinoma",
"13",
"years",
"ago.",
"The",
"prostate",
"specific",
"antigen",
"level",
"was",
"not",
"elevated.",
"An",
"abdominopelvic",
"computed",
"tomography",
"(CT)",
"scan",
"showed",
"markedly",
"enlarged",
"seminal",
"vesicles",
"causing",
"bilateral",
"ureteral",
"obstruction",
"and",
"a",
"mildly",
"enlarged",
"prostate.",
"Further",
"evaluation",
"with",
"fluorine-18-fluorodeoxyglucose",
"(18F-FDG)",
"positron",
"emission",
"tomography/CT",
"demonstrated",
"extensive",
"18F-FDG",
"uptake",
"in",
"the",
"pelvis",
"with",
"diffuse",
"involvement",
"of",
"both",
"seminal",
"vesicles",
"and",
"the",
"prostate",
"without",
"pathologic",
"uptake",
"in",
"the",
"lungs",
"or",
"elsewhere",
"in",
"the",
"body.",
"Core",
"biopsies",
"of",
"the",
"prostate",
"and",
"both",
"seminal",
"vesicles",
"revealed",
"diffuse",
"involvement",
"by",
"small",
"cell",
"carcinoma.",
"Therapy",
"could",
"not",
"be",
"instituted",
"due",
"to",
"a",
"rapid",
"deterioration",
"in",
"the",
"patient's",
"clinical",
"condition."
] | [
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[
"Phosphodiesterase",
"Type",
"5",
"Inhibitors",
"and",
"Risk",
"of",
"Malignant",
"Melanoma:",
"Matched",
"Cohort",
"Study",
"Using",
"Primary",
"Care",
"Data",
"from",
"the",
"UK",
"Clinical",
"Practice",
"Research",
"Datalink",
"Laboratory",
"evidence",
"suggests",
"that",
"reduced",
"phosphodiesterase",
"type",
"5",
"(PDE5)",
"expression",
"increases",
"the",
"invasiveness",
"of",
"melanoma",
"cells;",
"hence,",
"pharmacological",
"inhibition",
"of",
"PDE5",
"could",
"affect",
"melanoma",
"risk.",
"Two",
"major",
"epidemiological",
"studies",
"have",
"investigated",
"this",
"and",
"come",
"to",
"differing",
"conclusions.",
"We",
"therefore",
"aimed",
"to",
"investigate",
"whether",
"PDE5",
"inhibitor",
"use",
"is",
"associated",
"with",
"an",
"increased",
"risk",
"of",
"malignant",
"melanoma,",
"and",
"whether",
"any",
"increase",
"in",
"risk",
"is",
"likely",
"to",
"represent",
"a",
"causal",
"relationship.",
"We",
"conducted",
"a",
"matched",
"cohort",
"study",
"using",
"primary",
"care",
"data",
"from",
"the",
"UK",
"Clinical",
"Practice",
"Research",
"Datalink.",
"All",
"men",
"initiating",
"a",
"PDE5",
"inhibitor",
"and",
"with",
"no",
"prior",
"cancer",
"diagnosis",
"were",
"identified",
"and",
"matched",
"on",
"age,",
"diabetes",
"status,",
"and",
"general",
"practice",
"to",
"up",
"to",
"four",
"unexposed",
"controls.",
"Ever",
"use",
"of",
"a",
"PDE5",
"inhibitor",
"and",
"time-updated",
"cumulative",
"number",
"of",
"PDE5",
"inhibitor",
"prescriptions",
"were",
"investigated",
"as",
"exposures,",
"and",
"the",
"primary",
"outcome",
"was",
"malignant",
"melanoma.",
"Basal",
"cell",
"carcinoma,",
"solar",
"keratosis,",
"and",
"colorectal",
"cancer",
"were",
"investigated",
"as",
"negative",
"control",
"outcomes",
"to",
"exclude",
"bias.",
"Hazard",
"ratios",
"(HRs)",
"were",
"estimated",
"from",
"Cox",
"models",
"stratified",
"by",
"matched",
"set",
"and",
"adjusted",
"for",
"potential",
"confounders.",
"145,104",
"men",
"with",
"≥1",
"PDE5",
"inhibitor",
"prescription,",
"and",
"560,933",
"unexposed",
"matched",
"controls",
"were",
"included.",
"In",
"total,",
"1,315",
"incident",
"malignant",
"melanoma",
"diagnoses",
"were",
"observed",
"during",
"3.44",
"million",
"person-years",
"of",
"follow-up",
"(mean",
"4.9",
"y",
"per",
"person).",
"After",
"adjusting",
"for",
"potential",
"confounders,",
"there",
"was",
"weak",
"evidence",
"of",
"a",
"small",
"positive",
"association",
"between",
"PDE5",
"inhibitor",
"use",
"and",
"melanoma",
"risk",
"(HR",
"=",
"1.14,",
"95%",
"CI",
"1.01-1.29,",
"p",
"=",
"0.04).",
"A",
"similar",
"increase",
"in",
"risk",
"was",
"seen",
"for",
"the",
"two",
"negative",
"control",
"outcomes",
"related",
"to",
"sun",
"exposure",
"(HR",
"=",
"1.15,",
"95%",
"CI",
"1.11-1.19,",
"p",
"<",
"0.001,",
"for",
"basal",
"cell",
"carcinoma;",
"HR",
"=",
"1.21,",
"95%",
"CI",
"1.17-1.25,",
"p",
"<",
"0.001,",
"for",
"solar",
"keratosis),",
"but",
"there",
"was",
"no",
"increased",
"risk",
"for",
"colorectal",
"cancer",
"(HR",
"=",
"0.91,",
"95%",
"CI",
"0.85-0.98,",
"p",
"=",
"0.01).",
"There",
"was",
"no",
"evidence",
"that",
"risk",
"increased",
"with",
"number",
"of",
"prescriptions",
"received",
"(p-trend",
"=",
"0.83).",
"In",
"a",
"post",
"hoc",
"analysis,",
"there",
"was",
"strong",
"evidence",
"that",
"solar",
"keratosis",
"was",
"associated",
"with",
"future",
"PDE5",
"inhibitor",
"use",
"(odds",
"ratio",
"=",
"1.28,",
"95%",
"CI",
"1.23-1.34,",
"p",
"<",
"0.001),",
"suggesting",
"that",
"men",
"with",
"higher",
"sun",
"exposure",
"were",
"more",
"likely",
"to",
"become",
"PDE5",
"inhibitor",
"users.",
"However,",
"a",
"limitation",
"of",
"our",
"study",
"was",
"that",
"we",
"did",
"not",
"have",
"individual-level",
"data",
"on",
"sun",
"exposure,",
"so",
"we",
"could",
"not",
"directly",
"control",
"for",
"this",
"in",
"the",
"primary",
"analysis.",
"Our",
"results",
"were",
"not",
"consistent",
"with",
"PDE5",
"inhibitors",
"being",
"causally",
"associated",
"with",
"melanoma",
"risk,",
"and",
"strongly",
"suggest",
"that",
"observed",
"risk",
"increases",
"are",
"driven",
"by",
"greater",
"sun",
"exposure",
"among",
"patients",
"exposed",
"to",
"a",
"PDE5",
"inhibitor."
] | [
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[
"Parent",
"-",
"Youth",
"Differences",
"in",
"Familism",
"Values",
"from",
"Adolescence",
"into",
"Young",
"Adulthood:",
"Developmental",
"Course",
"and",
"Links",
"with",
"Parent",
"-",
"Youth",
"Conflict",
"A",
"critical",
"step",
"in",
"capturing",
"family",
"processes",
"is",
"to",
"incorporate",
"the",
"perspectives",
"and",
"experiences",
"of",
"multiple",
"family",
"members",
"toward",
"characterizing",
"how",
"families",
"operate",
"as",
"systems.",
"Although",
"some",
"research",
"has",
"examined",
"differences",
"between",
"parents'",
"and",
"youth's",
"family",
"experiences,",
"most",
"studies",
"have",
"focused",
"on",
"European",
"American",
"families,",
"and",
"we",
"know",
"little",
"about",
"the",
"nature",
"and",
"implications",
"of",
"divergent",
"parent",
"-",
"youth",
"experiences",
"in",
"other",
"ethnic",
"groups.",
"Accordingly,",
"we",
"focused",
"on",
"Mexican",
"-origin",
"families",
"and",
"assessed",
"the",
"links",
"between",
"mother",
"-",
"youth",
"and",
"father",
"-",
"youth",
"differences",
"in",
"familism",
"values",
"and",
"parent",
"-",
"youth",
"conflict",
"from",
"early",
"adolescence",
"into",
"young",
"adulthood.",
"Participants",
"were",
"mothers,",
"fathers,",
"and",
"two",
"siblings",
"(248",
"female",
"and",
"244",
"male,",
"51",
"%",
"female;",
"M",
"age",
"=",
"14.02",
"years)",
"from",
"246",
"families",
"who",
"were",
"interviewed",
"in",
"their",
"homes",
"on",
"three",
"occasions",
"over",
"8",
"years.",
"We",
"operationalized",
"parent",
"-",
"youth",
"differences",
"in",
"familism",
"values",
"using",
"difference",
"scores,",
"controlling",
"for",
"mean",
"levels",
"of",
"familism.",
"Multilevel",
"models",
"revealed",
"that",
"mothers",
"'",
"and",
"fathers",
"'",
"familism",
"values",
"remained",
"relatively",
"stable",
"over",
"time,",
"but",
"youth's",
"familism",
"values",
"declined",
"until",
"age",
"17,",
"stabilized,",
"and",
"then",
"increased",
"slightly",
"in",
"young",
"adulthood.",
"Lagged",
"models",
"tested",
"directions",
"of",
"effect",
"by",
"examining",
"whether",
"parent",
"-",
"youth",
"differences",
"in",
"familism",
"values",
"predicted",
"parent",
"-",
"youth",
"conflict",
"or",
"vice",
"versa.",
"The",
"findings",
"revealed",
"that",
"parent",
"-",
"youth",
"conflict",
"predicted",
"greater",
"differences",
"in",
"parent",
"-",
"youth",
"familism",
"values,",
"but",
"differences",
"in",
"familism",
"values",
"did",
"not",
"predict",
"conflict.",
"Our",
"findings",
"align",
"with",
"a",
"family",
"systems",
"perspective",
"in",
"documenting",
"the",
"significance",
"of",
"differences",
"between",
"family",
"members",
"'",
"perspectives",
"and",
"highlighting",
"that",
"such",
"processes",
"are",
"dynamic.",
"Further,",
"by",
"testing",
"bi-directional",
"associations",
"in",
"longitudinal",
"models,",
"we",
"were",
"able",
"to",
"disentangle",
"the",
"temporal",
"ordering",
"of",
"differences",
"in",
"familism",
"values",
"and",
"parent",
"-",
"youth",
"conflict",
"thereby",
"advancing",
"understanding",
"of",
"parent",
"-",
"youth",
"discrepancies",
"in",
"cultural",
"values."
] | [
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1,
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[
"Low",
"Soluble",
"Syndecan-1",
"Precedes",
"Preeclampsia",
"Syndecan-1",
"(Sdc1;",
"CD138)",
"is",
"a",
"major",
"transmembrane",
"heparan",
"sulfate",
"proteoglycan",
"expressed",
"on",
"the",
"extracellular,",
"luminal",
"surface",
"of",
"epithelial",
"cells",
"and",
"syncytiotrophoblast,",
"thus",
"comprising",
"a",
"major",
"component",
"of",
"the",
"glycocalyx",
"of",
"these",
"cells.",
"The",
"\"",
"soluble",
"\"",
"(shed)",
"form",
"of",
"Sdc1",
"has",
"paracrine",
"and",
"autocrine",
"functions",
"and",
"is",
"normally",
"produced",
"in",
"a",
"regulated",
"fashion.",
"We",
"compared",
"plasma",
"soluble",
"Sdc1",
"concentrations,",
"in",
"relation",
"to",
"placental",
"Sdc1",
"expression,",
"in",
"uncomplicated",
"(control)",
"and",
"preeclamptic",
"pregnancies.",
"We",
"evaluated",
"soluble",
"Sdc1",
"across",
"uncomplicated",
"pregnancy,",
"and",
"between",
"preeclamptic,",
"gestational",
"hypertensive",
"and",
"control",
"patients",
"at",
"mid-pregnancy",
"(20",
"weeks)",
"and",
"3rd",
"trimester",
"by",
"ELISA.",
"Placental",
"expression",
"level",
"of",
"Sdc1",
"was",
"compared",
"between",
"groups",
"in",
"relation",
"to",
"pre-delivery",
"plasma",
"soluble",
"Sdc1.",
"Participants",
"were",
"recruited",
"from",
"Magee-Womens",
"Hospital.",
"In",
"uncomplicated",
"pregnancy,",
"plasma",
"soluble",
"Sdc1",
"rose",
"significantly",
"in",
"the",
"1st",
"trimester,",
"and",
"reached",
"an",
"approximate",
"50-fold",
"increase",
"at",
"term",
"compared",
"to",
"post",
"pregnancy",
"levels.",
"Soluble",
"Sdc1",
"was",
"lower",
"at",
"mid-pregnancy",
"in",
"women",
"who",
"later",
"developed",
"preeclampsia",
"(P<0.05),",
"but",
"not",
"gestational",
"hypertension,",
"compared",
"to",
"controls,",
"and",
"remained",
"lower",
"at",
"late",
"pregnancy",
"in",
"preeclampsia",
"(P<0.01)",
"compared",
"to",
"controls.",
"Sdc1",
"was",
"prominently",
"expressed",
"on",
"syncytiotrophoblast",
"of",
"microvilli.",
"Syncytiotrophoblast",
"Sdc1",
"immunostaining",
"intensities,",
"and",
"mRNA",
"content",
"in",
"villous",
"homogenates,",
"were",
"lower",
"in",
"preeclampsia",
"vs.",
"controls",
"(P<0.05).",
"Soluble",
"Sdc1",
"and",
"Sdc1",
"immunostaining",
"scores",
"were",
"inversely",
"associated",
"with",
"systolic",
"blood",
"pressures,",
"and",
"positively",
"correlated",
"with",
"infant",
"birth",
"weight",
"percentile.",
"Soluble",
"Sdc1",
"is",
"significantly",
"lower",
"before",
"the",
"clinical",
"onset",
"of",
"preeclampsia,",
"with",
"reduced",
"expression",
"of",
"Sdc1",
"in",
"the",
"delivered",
"placenta,",
"suggesting",
"a",
"role",
"for",
"glycocalyx",
"disturbance",
"in",
"preeclampsia",
"pathophysiology."
] | [
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[
"Synthesis",
"and",
"Photophysical",
"Properties",
"of",
"Fluorescence",
"Molecular",
"Probe",
"for",
"Turn-ON-Type",
"Detection",
"of",
"Cytosine",
"Bulge",
"DNA",
"A",
"fluorescent",
"molecule",
"DANP",
"that",
"binds",
"to",
"cytosine",
"bulge",
"DNA",
"and",
"emits",
"characteristic",
"fluorescence",
"was",
"conjugated",
"to",
"pyrene",
"to",
"give",
"a",
"new",
"fluorescence",
"probe",
"PyDANP.",
"Temperature",
"-",
"and",
"solvent",
"-dependent",
"absorption",
"changes",
"showed",
"that",
"DANP",
"and",
"pyrene",
"chromophores",
"stacked",
"at",
"room",
"temperature",
"in",
"an",
"aqueous",
"buffer",
"solution",
"and",
"quenched",
"fluorescence.",
"Upon",
"binding",
"of",
"DANP",
"moiety",
"in",
"PyDANP",
"to",
"cytosine",
"bulge",
"DNA,",
"the",
"fluorescence",
"from",
"DANP",
"bound",
"to",
"C-bulge",
"increased",
"by",
"∼12-fold,",
"showing",
"that",
"PyDANP",
"is",
"a",
"turn-ON",
"probe",
"for",
"the",
"detection",
"of",
"C-bulge",
"DNA."
] | [
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[
"Bispectral",
"pairwise",
"interacting",
"source",
"analysis",
"for",
"identifying",
"systems",
"of",
"cross-frequency",
"interacting",
"brain",
"sources",
"from",
"electroencephalographic",
"or",
"magnetoencephalographic",
"signals",
"Brain",
"cognitive",
"functions",
"arise",
"through",
"the",
"coordinated",
"activity",
"of",
"several",
"brain",
"regions,",
"which",
"actually",
"form",
"complex",
"dynamical",
"systems",
"operating",
"at",
"multiple",
"frequencies.",
"These",
"systems",
"often",
"consist",
"of",
"interacting",
"subsystems,",
"whose",
"characterization",
"is",
"of",
"importance",
"for",
"a",
"complete",
"understanding",
"of",
"the",
"brain",
"interaction",
"processes.",
"To",
"address",
"this",
"issue,",
"we",
"present",
"a",
"technique,",
"namely",
"the",
"bispectral",
"pairwise",
"interacting",
"source",
"analysis",
"(biPISA),",
"for",
"analyzing",
"systems",
"of",
"cross-frequency",
"interacting",
"brain",
"sources",
"when",
"multichannel",
"electroencephalographic",
"(EEG)",
"or",
"magnetoencephalographic",
"(MEG)",
"data",
"are",
"available.",
"Specifically,",
"the",
"biPISA",
"makes",
"it",
"possible",
"to",
"identify",
"one",
"or",
"many",
"subsystems",
"of",
"cross-frequency",
"interacting",
"sources",
"by",
"decomposing",
"the",
"antisymmetric",
"components",
"of",
"the",
"cross-bispectra",
"between",
"EEG",
"or",
"MEG",
"signals,",
"based",
"on",
"the",
"assumption",
"that",
"interactions",
"are",
"pairwise.",
"Thanks",
"to",
"the",
"properties",
"of",
"the",
"antisymmetric",
"components",
"of",
"the",
"cross-bispectra,",
"biPISA",
"is",
"also",
"robust",
"to",
"spurious",
"interactions",
"arising",
"from",
"mixing",
"artifacts,",
"i.e.,",
"volume",
"conduction",
"or",
"field",
"spread,",
"which",
"always",
"affect",
"EEG",
"or",
"MEG",
"functional",
"connectivity",
"estimates.",
"This",
"method",
"is",
"an",
"extension",
"of",
"the",
"pairwise",
"interacting",
"source",
"analysis",
"(PISA),",
"which",
"was",
"originally",
"introduced",
"for",
"investigating",
"interactions",
"at",
"the",
"same",
"frequency,",
"to",
"the",
"study",
"of",
"cross-frequency",
"interactions.",
"The",
"effectiveness",
"of",
"this",
"approach",
"is",
"demonstrated",
"in",
"simulations",
"for",
"up",
"to",
"three",
"interacting",
"source",
"pairs",
"and",
"for",
"real",
"MEG",
"recordings",
"of",
"spontaneous",
"brain",
"activity.",
"Simulations",
"show",
"that",
"the",
"performances",
"of",
"biPISA",
"in",
"estimating",
"the",
"phase",
"difference",
"between",
"the",
"interacting",
"sources",
"are",
"affected",
"by",
"the",
"increasing",
"level",
"of",
"noise",
"rather",
"than",
"by",
"the",
"number",
"of",
"the",
"interacting",
"subsystems.",
"The",
"analysis",
"of",
"real",
"MEG",
"data",
"reveals",
"an",
"interaction",
"between",
"two",
"pairs",
"of",
"sources",
"of",
"central",
"mu",
"and",
"beta",
"rhythms,",
"localizing",
"in",
"the",
"proximity",
"of",
"the",
"left",
"and",
"right",
"central",
"sulci."
] | [
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[
"Palmitoyl",
"Glycol",
"Chitosan",
"Micelles",
"for",
"Corneal",
"Delivery",
"of",
"Cyclosporine",
"Different",
"substitution",
"degrees",
"of",
"palmitoyl",
"glycol",
"chitosan",
"(PGC),",
"prepared",
"according",
"to",
"the",
"literature,",
"were",
"used",
"to",
"obtain",
"polymeric",
"micelles",
"that",
"have",
"been",
"assessed",
"in",
"comparison",
"with",
"Pluronic",
"F127",
"micelles",
"as",
"possible",
"carriers",
"for",
"poorly",
"soluble",
"drugs,",
"such",
"as",
"cyclosporine",
"A.",
"Both",
"PGC",
"and",
"Pluronic",
"micelles",
"were",
"studied",
"for",
"their",
"interactions",
"with",
"cell",
"culture",
"substrates.",
"The",
"least",
"substituted",
"and",
"most",
"hydrophilic",
"derivative,",
"PGC21",
"(approximately",
"5%",
"substitution),",
"showed",
"a",
"strong",
"association",
"with",
"cyclosporine,",
"more",
"than",
"tripling",
"the",
"colloidal",
"concentration",
"with",
"respect",
"to",
"the",
"saturated",
"solution.",
"It",
"showed",
"a",
"greater",
"ability",
"to",
"open",
"Caco-2",
"tight",
"junctions",
"and",
"to",
"enhance",
"the",
"permeability",
"of",
"Caco-2",
"substrates",
"with",
"respect",
"to",
"micelles",
"based",
"on",
"higher",
"palmitoyl",
"substitution,",
"conceivably",
"due",
"to",
"the",
"lower",
"modification",
"of",
"the",
"chitosan",
"chains.",
"Permeation",
"and",
"penetration",
"experiments",
"were",
"performed",
"with",
"PGC21",
"and",
"Pluronic",
"micelles",
"on",
"a",
"rabbit",
"corneal",
"epithelial",
"cell",
"line",
"(RCE)",
"and",
"on",
"excised",
"pig",
"corneas.",
"It",
"was",
"found",
"that",
"both",
"PGC",
"and",
"Pluronic",
"micelles",
"could",
"increase",
"the",
"permeation",
"of",
"the",
"fluorescent",
"probe",
"rhodamine",
"B",
"through",
"RCE",
"cells",
"by",
"more",
"than",
"ten-fold.",
"In",
"RCE",
"and",
"in",
"pig",
"cornea,",
"the",
"micelles",
"improved",
"the",
"penetration",
"of",
"both",
"rhodamine",
"andr",
"cyclosporine.",
"For",
"cyclosporine,",
"the",
"PGC21",
"micelles",
"allowed",
"penetration",
"of",
"approximately",
"1",
"μg/mg",
"cyclosporine",
"A",
"in",
"corneal",
"tissue,",
"demonstrating",
"a",
"potential",
"for",
"use",
"in",
"immunosuppression",
"therapies."
] | [
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[
"Plasmodium",
"falciparum",
"parasite",
"population",
"structure",
"and",
"gene",
"flow",
"associated",
"to",
"anti-malarial",
"drugs",
"resistance",
"in",
"Cambodia",
"Western",
"Cambodia",
"is",
"recognized",
"as",
"the",
"epicentre",
"of",
"emergence",
"of",
"Plasmodium",
"falciparum",
"multi-drug",
"resistance.",
"The",
"emergence",
"of",
"artemisinin",
"resistance",
"has",
"been",
"observed",
"in",
"this",
"area",
"since",
"2008-2009",
"and",
"molecular",
"signatures",
"associated",
"to",
"artemisinin",
"resistance",
"have",
"been",
"characterized",
"in",
"k13",
"gene.",
"At",
"present,",
"one",
"of",
"the",
"major",
"threats",
"faced,",
"is",
"the",
"possible",
"spread",
"of",
"Asian",
"artemisinin",
"resistant",
"parasites",
"over",
"the",
"world",
"threatening",
"millions",
"of",
"people",
"and",
"jeopardizing",
"malaria",
"elimination",
"programme",
"efforts.",
"To",
"anticipate",
"the",
"diffusion",
"of",
"artemisinin",
"resistance,",
"the",
"identification",
"of",
"the",
"P.",
"falciparum",
"population",
"structure",
"and",
"the",
"gene",
"flow",
"among",
"the",
"parasite",
"population",
"in",
"Cambodia",
"are",
"essential.",
"To",
"this",
"end,",
"a",
"mid-throughput",
"PCR",
"-",
"LDR-FMA",
"approach",
"based",
"on",
"LUMINEX",
"technology",
"was",
"developed",
"to",
"screen",
"for",
"genetic",
"barcode",
"in",
"533",
"blood",
"samples",
"collected",
"in",
"2010-2011",
"from",
"16",
"health",
"centres",
"in",
"malaria",
"endemics",
"areas",
"in",
"Cambodia.",
"Based",
"on",
"successful",
"typing",
"of",
"282",
"samples,",
"subpopulations",
"were",
"characterized",
"along",
"the",
"borders",
"of",
"the",
"country.",
"Each",
"11-loci",
"barcode",
"provides",
"evidence",
"supporting",
"allele",
"distribution",
"gradient",
"related",
"to",
"subpopulations",
"and",
"gene",
"flow.",
"The",
"11-loci",
"barcode",
"successfully",
"identifies",
"recently",
"emerging",
"parasite",
"subpopulations",
"in",
"western",
"Cambodia",
"that",
"are",
"associated",
"with",
"the",
"C580Y",
"dominant",
"allele",
"for",
"artemisinin",
"resistance",
"in",
"k13",
"gene.",
"A",
"subpopulation",
"was",
"identified",
"in",
"northern",
"Cambodia",
"that",
"was",
"associated",
"to",
"artemisinin",
"(R539T",
"resistant",
"allele",
"of",
"k13",
"gene)",
"and",
"mefloquine",
"resistance.",
"The",
"gene",
"flow",
"between",
"these",
"subpopulations",
"might",
"have",
"driven",
"the",
"spread",
"of",
"artemisinin",
"resistance",
"over",
"Cambodia."
] | [
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[
"Mining",
"Health",
"App",
"Data",
"to",
"Find",
"More",
"and",
"Less",
"Successful",
"Weight",
"Loss",
"Subgroups",
"More",
"than",
"half",
"of",
"all",
"smartphone",
"app",
"downloads",
"involve",
"weight,",
"diet,",
"and",
"exercise.",
"If",
"successful,",
"these",
"lifestyle",
"apps",
"may",
"have",
"far-reaching",
"effects",
"for",
"disease",
"prevention",
"and",
"health",
"cost-savings,",
"but",
"few",
"researchers",
"have",
"analyzed",
"data",
"from",
"these",
"apps.",
"The",
"purposes",
"of",
"this",
"study",
"were",
"to",
"analyze",
"data",
"from",
"a",
"commercial",
"health",
"app",
"(Lose",
"It!)",
"in",
"order",
"to",
"identify",
"successful",
"weight",
"loss",
"subgroups",
"via",
"exploratory",
"analyses",
"and",
"to",
"verify",
"the",
"stability",
"of",
"the",
"results.",
"Cross-sectional,",
"de-identified",
"data",
"from",
"Lose",
"It!",
"were",
"analyzed.",
"This",
"dataset",
"(n=12,427,196)",
"was",
"randomly",
"split",
"into",
"24",
"subsamples,",
"and",
"this",
"study",
"used",
"3",
"subsamples",
"(combined",
"n=972,687).",
"Classification",
"and",
"regression",
"tree",
"methods",
"were",
"used",
"to",
"explore",
"groupings",
"of",
"weight",
"loss",
"with",
"one",
"subsample,",
"with",
"descriptive",
"analyses",
"to",
"examine",
"other",
"group",
"characteristics.",
"Data",
"mining",
"validation",
"methods",
"were",
"conducted",
"with",
"2",
"additional",
"subsamples.",
"In",
"subsample",
"1,",
"14.96%",
"of",
"users",
"lost",
"5%",
"or",
"more",
"of",
"their",
"starting",
"body",
"weight.",
"Classification",
"and",
"regression",
"tree",
"analysis",
"identified",
"3",
"distinct",
"subgroups:",
"\"the",
"occasional",
"users",
"\"",
"had",
"the",
"lowest",
"proportion",
"(4.87%)",
"of",
"individuals",
"who",
"successfully",
"lost",
"weight;",
"\"the",
"basic",
"users",
"\"",
"had",
"37.61%",
"weight",
"loss",
"success;",
"and",
"\"the",
"power",
"users",
"\"",
"achieved",
"the",
"highest",
"percentage",
"of",
"weight",
"loss",
"success",
"at",
"72.70%.",
"Behavioral",
"factors",
"delineated",
"the",
"subgroups,",
"though",
"app",
"-related",
"behavioral",
"characteristics",
"further",
"distinguished",
"them.",
"Results",
"were",
"replicated",
"in",
"further",
"analyses",
"with",
"separate",
"subsamples.",
"This",
"study",
"demonstrates",
"that",
"distinct",
"subgroups",
"can",
"be",
"identified",
"in",
"\"messy\"",
"commercial",
"app",
"data",
"and",
"the",
"identified",
"subgroups",
"can",
"be",
"replicated",
"in",
"independent",
"samples.",
"Behavioral",
"factors",
"and",
"use",
"of",
"custom",
"app",
"features",
"characterized",
"the",
"subgroups.",
"Targeting",
"and",
"tailoring",
"information",
"to",
"particular",
"subgroups",
"could",
"enhance",
"weight",
"loss",
"success.",
"Future",
"studies",
"should",
"replicate",
"data",
"mining",
"analyses",
"to",
"increase",
"methodology",
"rigor."
] | [
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[
"Recognising",
"and",
"responding",
"to",
"'",
"cutting",
"corners",
"'",
"when",
"providing",
"nursing",
"care:",
"a",
"qualitative",
"study",
"The",
"aim",
"of",
"this",
"study",
"is",
"to",
"report",
"on",
"a",
"key",
"finding",
"of",
"a",
"larger",
"study",
"investigating",
"the",
"'",
"gaps",
"'",
"in",
"patient",
"care",
"that",
"registered",
"nurses",
"encounter",
"during",
"the",
"course",
"of",
"their",
"practice.",
"A",
"key",
"finding",
"of",
"this",
"larger",
"study",
"was",
"that",
"'",
"cutting",
"corners",
"'",
"was",
"a",
"gap",
"discerned",
"by",
"nurses.",
"'",
"Cutting",
"corners",
"'",
"has",
"been",
"characterised",
"as",
"a",
"'",
"violation",
"'",
"and",
"threat",
"to",
"patient",
"safety,",
"although",
"there",
"is",
"a",
"paucity",
"of",
"research",
"on",
"this",
"issue.",
"Naturalistic",
"inquiry",
"using",
"a",
"qualitative",
"exploratory",
"descriptive",
"approach.",
"Data",
"were",
"collected",
"from",
"a",
"purposeful",
"sample",
"of",
"71",
"registered",
"nurses",
"from",
"emergency",
"department,",
"critical",
"care,",
"perioperative,",
"rehabilitation",
"and",
"transitional",
"care",
"and",
"neurosciences",
"settings",
"in",
"Australia",
"and",
"analysed",
"using",
"content",
"and",
"thematic",
"analysis",
"strategies.",
"Cutting",
"corners",
"was",
"a",
"common",
"practice",
"that",
"encompassed",
"(1)",
"the",
"partial",
"or",
"complete",
"omission",
"of",
"patient",
"care,",
"(2)",
"delays",
"in",
"providing",
"care",
"and",
"(3)",
"the",
"failure",
"to",
"do",
"things",
"correctly.",
"Corners",
"were",
"cut",
"in",
"patient",
"assessment,",
"essential",
"nursing",
"care,",
"the",
"care",
"of",
"central",
"venous",
"catheters",
"and",
"medication",
"administration.",
"The",
"practice",
"of",
"cutting",
"corners",
"was",
"perceived",
"as",
"contributing",
"to",
"preventable",
"adverse",
"events.",
"The",
"study",
"found",
"that",
"cutting",
"corners",
"created",
"gaps",
"that",
"contributed",
"to",
"unfinished",
"nursing",
"care",
"and",
"preventable",
"adverse",
"events.",
"The",
"findings",
"of",
"the",
"study",
"raise",
"the",
"possibility",
"that",
"cutting",
"corners",
"is",
"a",
"salient",
"but",
"underinvestigated",
"characteristic",
"of",
"nursing",
"practice.",
"Further",
"research",
"and",
"inquiry",
"are",
"needed",
"to",
"deepen",
"understanding",
"of",
"cutting",
"corners",
"and",
"its",
"impact",
"on",
"patient",
"safety.",
"Identifying",
"the",
"nature",
"and",
"implications",
"of",
"cutting",
"corners",
"when",
"providing",
"nursing",
"care",
"is",
"an",
"important",
"contributing",
"factor",
"to",
"improving",
"patient",
"safety",
"and",
"quality",
"care."
] | [
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[
"The",
"PP",
"-",
"motif",
"in",
"luminal",
"loop",
"2",
"of",
"ZnT",
"transporters",
"plays",
"a",
"pivotal",
"role",
"in",
"TNAP",
"activation",
"Secretory",
"and",
"membrane",
"-",
"bound",
"zinc",
"-requiring",
"enzymes",
"are",
"thought",
"to",
"be",
"activated",
"by",
"binding",
"zinc",
"in",
"the",
"early",
"secretory",
"pathway.",
"One",
"such",
"enzyme,",
"tissue-non-specific",
"alkaline",
"phosphatase",
"(TNAP),",
"is",
"activated",
"through",
"a",
"two-step",
"mechanism,",
"via",
"protein",
"stabilization",
"and",
"subsequent",
"enzyme",
"activation",
"through",
"metalation,",
"by",
"ZnT5",
"-",
"ZnT6",
"heterodimers",
"or",
"ZnT7",
"homodimers.",
"However,",
"little",
"is",
"known",
"about",
"the",
"molecular",
"basis",
"underlying",
"the",
"activation",
"process.",
"In",
"the",
"present",
"study,",
"we",
"found",
"that",
"the",
"di-proline",
"motif",
"(PP",
"-",
"motif)",
"in",
"luminal",
"loop",
"2",
"of",
"ZnT5",
"and",
"ZnT7",
"is",
"important",
"for",
"TNAP",
"activation.",
"TNAP",
"activity",
"was",
"significantly",
"reduced",
"in",
"cells",
"lacking",
"ZnT5",
"-",
"ZnT6",
"heterodimers",
"and",
"ZnT7",
"homodimers",
"[triple",
"knockout",
"(TKO)",
"cells].",
"The",
"decreased",
"TNAP",
"activity",
"was",
"restored",
"by",
"expressing",
"hZnT5",
"with",
"hZnT6",
"or",
"hZnT7,",
"but",
"significantly",
"less",
"so",
"(almost",
"90%",
"less)",
"by",
"expressing",
"mutants",
"thereof",
"in",
"which",
"the",
"PP",
"-",
"motif",
"was",
"mutated",
"to",
"alanine",
"(PP",
"-",
"AA).",
"In",
"TKO",
"cells,",
"overexpressed",
"hTNAP",
"was",
"not",
"completely",
"activated,",
"and",
"it",
"was",
"converted",
"less",
"efficiently",
"into",
"the",
"holo",
"form",
"by",
"expressing",
"a",
"PP",
"-",
"AA",
"mutant",
"of",
"hZnT5",
"with",
"hZnT6,",
"whose",
"defects",
"were",
"not",
"restored",
"by",
"zinc",
"supplementation.",
"The",
"zinc",
"transport",
"activity",
"of",
"hZnT7",
"was",
"not",
"significantly",
"impaired",
"by",
"the",
"PP",
"-",
"AA",
"mutation,",
"indicating",
"that",
"the",
"PP",
"-",
"motif",
"is",
"involved",
"in",
"the",
"TNAP",
"maturation",
"process,",
"although",
"it",
"does",
"not",
"control",
"zinc",
"transport",
"activity.",
"The",
"PP",
"-",
"motif",
"is",
"highly",
"conserved",
"in",
"ZnT5",
"and",
"ZnT7",
"orthologues,",
"and",
"its",
"importance",
"for",
"TNAP",
"activation",
"is",
"conserved",
"in",
"the",
"Caenorhabditis",
"elegans",
"hZnT5",
"orthologue",
"CDF5.",
"These",
"results",
"provide",
"novel",
"molecular",
"insights",
"into",
"the",
"TNAP",
"activation",
"process",
"in",
"the",
"early",
"secretory",
"pathway."
] | [
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[
"Novel",
"protein",
"-",
"inhibitor",
"interactions",
"in",
"site",
"3",
"of",
"Ca(2+)-bound",
"S100B",
"as",
"discovered",
"by",
"X-ray",
"crystallography",
"Structure-based",
"drug",
"discovery",
"is",
"under",
"way",
"to",
"identify",
"and",
"develop",
"small-molecule",
"S100B",
"inhibitors",
"(SBiXs).",
"Such",
"inhibitors",
"have",
"therapeutic",
"potential",
"for",
"treating",
"malignant",
"melanoma,",
"since",
"high",
"levels",
"of",
"S100B",
"downregulate",
"wild-type",
"p53",
"tumor",
"suppressor",
"function",
"in",
"this",
"cancer.",
"Computational",
"and",
"X-ray",
"crystallographic",
"studies",
"of",
"two",
"S100B",
"-",
"SBiX",
"complexes",
"are",
"described,",
"and",
"both",
"compounds",
"(apomorphine",
"hydrochloride",
"and",
"ethidium",
"bromide)",
"occupy",
"an",
"area",
"of",
"the",
"S100B",
"hydrophobic",
"cleft",
"which",
"is",
"termed",
"site",
"3.",
"These",
"data",
"also",
"reveal",
"novel",
"protein",
"-",
"inhibitor",
"interactions",
"which",
"can",
"be",
"used",
"in",
"future",
"drug-design",
"studies",
"to",
"improve",
"SBiX",
"affinity",
"and",
"specificity.",
"Of",
"particular",
"interest,",
"apomorphine",
"hydrochloride",
"showed",
"S100B",
"-dependent",
"killing",
"in",
"melanoma",
"cell",
"assays,",
"although",
"the",
"efficacy",
"exceeds",
"its",
"affinity",
"for",
"S100B",
"and",
"implicates",
"possible",
"off-target",
"contributions.",
"Because",
"there",
"are",
"no",
"structural",
"data",
"available",
"for",
"compounds",
"occupying",
"site",
"3",
"alone,",
"these",
"studies",
"contribute",
"towards",
"the",
"structure-based",
"approach",
"to",
"targeting",
"S100B",
"by",
"including",
"interactions",
"with",
"residues",
"in",
"site",
"3",
"of",
"S100B."
] | [
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[
"Ownership",
"and",
"Agency",
"of",
"an",
"Independent",
"Supernumerary",
"Hand",
"Induced",
"by",
"an",
"Imitation",
"Brain-Computer",
"Interface",
"To",
"study",
"body",
"ownership",
"and",
"control,",
"illusions",
"that",
"elicit",
"these",
"feelings",
"in",
"non-body",
"objects",
"are",
"widely",
"used.",
"Classically",
"introduced",
"with",
"the",
"Rubber",
"Hand",
"Illusion,",
"these",
"illusions",
"have",
"been",
"replicated",
"more",
"recently",
"in",
"virtual",
"reality",
"and",
"by",
"using",
"brain-computer",
"interfaces.",
"Traditionally",
"these",
"illusions",
"investigate",
"the",
"replacement",
"of",
"a",
"body",
"part",
"by",
"an",
"artificial",
"counterpart,",
"however",
"as",
"brain-computer",
"interface",
"research",
"develops",
"it",
"offers",
"us",
"the",
"possibility",
"to",
"explore",
"the",
"case",
"where",
"non-body",
"objects",
"are",
"controlled",
"in",
"addition",
"to",
"movements",
"of",
"our",
"own",
"limbs.",
"Therefore",
"we",
"propose",
"a",
"new",
"illusion",
"designed",
"to",
"test",
"the",
"feeling",
"of",
"ownership",
"and",
"control",
"of",
"an",
"independent",
"supernumerary",
"hand.",
"Subjects",
"are",
"under",
"the",
"impression",
"they",
"control",
"a",
"virtual",
"reality",
"hand",
"via",
"a",
"brain-computer",
"interface,",
"but",
"in",
"reality",
"there",
"is",
"no",
"causal",
"connection",
"between",
"brain",
"activity",
"and",
"virtual",
"hand",
"movement",
"but",
"correct",
"movements",
"are",
"observed",
"with",
"80%",
"probability.",
"These",
"imitation",
"brain-computer",
"interface",
"trials",
"are",
"interspersed",
"with",
"movements",
"in",
"both",
"the",
"subjects",
"'",
"real",
"hands,",
"which",
"are",
"in",
"view",
"throughout",
"the",
"experiment.",
"We",
"show",
"that",
"subjects",
"develop",
"strong",
"feelings",
"of",
"ownership",
"and",
"control",
"over",
"the",
"third",
"hand,",
"despite",
"only",
"receiving",
"visual",
"feedback",
"with",
"no",
"causal",
"link",
"to",
"the",
"actual",
"brain",
"signals.",
"Our",
"illusion",
"is",
"crucially",
"different",
"from",
"previously",
"reported",
"studies",
"as",
"we",
"demonstrate",
"independent",
"ownership",
"and",
"control",
"of",
"the",
"third",
"hand",
"without",
"loss",
"of",
"ownership",
"in",
"the",
"real",
"hands."
] | [
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[
"Vitamin",
"D",
"deficiency",
"in",
"pregnancy",
"may",
"affect",
"fetal",
"thymus",
"development",
"The",
"aim",
"of",
"our",
"study",
"was",
"to",
"evaluate",
"the",
"association",
"of",
"vitamin",
"D",
"deficiency",
"(VDD)",
"during",
"pregnancy",
"with",
"thymus",
"size",
"in",
"full-term",
"fetuses.",
"In",
"this",
"prospective",
"study,",
"we",
"evaluated",
"mid-pregnancy",
"serum",
"25-hydroxyvitamin",
"D3",
"(25(OH)D3)",
"concentrations.",
"The",
"fetal",
"thymus",
"size",
"was",
"measured",
"by",
"ultrasound",
"in",
"the",
"third",
"trimester.",
"Neonatal",
"25(OH)D3",
"levels",
"were",
"evaluated",
"by",
"umbilical",
"cord",
"blood",
"sampling.",
"Correlation",
"of",
"maternal",
"and",
"neonatal",
"vitamin",
"D",
"levels",
"and",
"association",
"between",
"thymus",
"size",
"and",
"both,",
"maternal",
"and",
"neonatal",
"vitamin",
"D",
"concentrations",
"were",
"investigated.",
"Serum",
"25(OH)",
"D3",
"concentrations",
"were",
"within",
"the",
"normal",
"range",
"in",
"48",
"(29.8%)",
"mothers",
"and",
"10",
"(13.1%)",
"new-borns.",
"A",
"strong",
"correlation",
"between",
"mid-pregnancy",
"maternal",
"and",
"neonatal",
"25(OH)D3",
"concentration",
"(r",
"=",
"0.8,",
"p",
"<",
"0.001)",
"was",
"found.",
"A",
"significant",
"linear",
"correlation",
"was",
"observed",
"between",
"both,",
"maternal",
"and",
"neonatal",
"25(OH)D3",
"concentrations",
"and",
"thymus",
"perimeter",
"length",
"(r",
"=",
"0.45,",
"p",
"=",
"0.04",
"and",
"r",
"=",
"0.43,",
"p",
"<",
"0.01,",
"respectively).",
"Both,",
"maternal",
"and",
"fetal",
"VDDs",
"were",
"associated",
"with",
"decreased",
"thymus",
"perimeter",
"(p",
"=",
"0.04,",
"p",
"=",
"0.03).",
"Vitamin",
"D",
"deficiency",
"during",
"pregnancy",
"may",
"be",
"associated",
"with",
"smaller",
"fetal",
"thymus.",
"Our",
"data",
"suggest",
"that",
"VDD",
"in",
"pregnancy",
"may",
"lead",
"to",
"systemic",
"inflammatory",
"response",
"in",
"the",
"fetus."
] | [
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[
"What",
"will",
"it",
"take",
"to",
"improve",
"prevention",
"of",
"chronic",
"diseases",
"in",
"Australia?",
"A",
"case",
"study",
"of",
"two",
"national",
"approaches",
"Objective",
"Despite",
"being",
"a",
"healthy",
"country",
"by",
"international",
"standards,",
"Australia",
"has",
"a",
"growing",
"and",
"serious",
"burden",
"from",
"chronic",
"diseases.",
"There",
"have",
"been",
"several",
"national",
"efforts",
"to",
"tackle",
"this",
"problem,",
"but",
"despite",
"some",
"important",
"advances",
"much",
"more",
"needs",
"to",
"be",
"done.",
"From",
"the",
"viewpoint",
"of",
"diverse",
"stakeholders,",
"the",
"present",
"study",
"examined",
"two",
"approaches",
"to",
"controlling",
"chronic",
"disease",
"in",
"Australia:",
"(1)",
"the",
"2005",
"National",
"Chronic",
"Disease",
"Strategy",
"(NCDS);",
"and",
"(2)",
"the",
"2008",
"National",
"Partnership",
"Agreement",
"on",
"Preventive",
"Health",
"(NPAPH).Methods",
"Individual",
"and",
"small",
"group",
"semistructured",
"interviews",
"were",
"undertaken",
"with",
"29",
"leaders",
"across",
"Australia,",
"reflecting",
"a",
"diverse",
"cross-section",
"of",
"senior",
"public",
"health",
"managers",
"and",
"program",
"implementation",
"staff",
"from",
"state",
"and",
"territory",
"health",
"departments,",
"as",
"well",
"as",
"academics,",
"thought",
"leaders",
"and",
"public",
"health",
"advocates.",
"A",
"grounded",
"theory",
"approach",
"was",
"used",
"to",
"generate",
"themes",
"relevant",
"to",
"the",
"research.Results",
"There",
"is",
"general",
"support",
"for",
"national",
"approaches",
"to",
"the",
"prevention",
"of",
"chronic",
"disease.",
"The",
"NCDS",
"was",
"viewed",
"as",
"necessary",
"and",
"useful",
"for",
"national",
"coordination,",
"setting",
"a",
"common",
"agenda",
"and",
"serving",
"as",
"an",
"anchor",
"to",
"align",
"jurisdictional",
"priorities",
"and",
"action.",
"However,",
"without",
"funding",
"or",
"other",
"infrastructure",
"commitments",
"or",
"implementation",
"plans,",
"any",
"expectations",
"as",
"to",
"what",
"could",
"be",
"meaningfully",
"achieved",
"were",
"limited.",
"In",
"contrast,",
"although",
"jurisdictions",
"welcomed",
"the",
"NPAPH,",
"its",
"associated",
"funding",
"and",
"the",
"opportunity",
"to",
"tailor",
"strategy",
"to",
"their",
"unique",
"needs",
"and",
"populations,",
"there",
"were",
"calls",
"for",
"greater",
"national",
"leadership",
"as",
"well",
"as",
"guidance",
"on",
"the",
"evidence",
"base",
"to",
"inform",
"decision",
"making.",
"Key",
"aspects",
"of",
"successful",
"national",
"action",
"were",
"strong",
"Australian",
"Government",
"leadership",
"and",
"coordination,",
"setting",
"a",
"common",
"agenda,",
"national",
"alignment",
"on",
"priorities,",
"evidence-informed",
"implementation",
"strategies,",
"partnerships",
"within",
"and",
"across",
"governments,",
"as",
"well",
"as",
"with",
"other",
"sectors,",
"and",
"funding",
"and",
"infrastructure",
"to",
"support",
"implementation",
".Conclusions",
"Both",
"the",
"NCDS",
"and",
"NPAPH",
"were",
"seen",
"to",
"have",
"overlapping",
"strengths",
"and",
"weaknesses.",
"A",
"key",
"need",
"identified",
"was",
"for",
"future",
"approaches",
"to",
"focus",
"on",
"generating",
"more",
"sustainable,",
"system-wide",
"change.What",
"is",
"known",
"about",
"the",
"topic?",
"Despite",
"some",
"important",
"advances,",
"chronic",
"diseases",
"remain",
"Australia",
"'s",
"greatest",
"health",
"challenge.",
"In",
"efforts",
"to",
"tackle",
"this",
"increasing",
"burden",
"from",
"chronic",
"diseases,",
"several",
"large-scale,",
"national",
"initiatives",
"have",
"been",
"released",
"in",
"Australia",
"over",
"recent",
"years,",
"including",
"the",
"2005",
"NCDS",
"and",
"the",
"2008",
"NPAPH",
".What",
"does",
"this",
"paper",
"add?",
"From",
"the",
"viewpoint",
"of",
"practitioners,",
"policy",
"makers,",
"advocates,",
"researchers",
"and",
"public",
"health",
"thought",
"leaders,",
"this",
"paper",
"examines",
"the",
"usefulness",
"and",
"significance",
"of",
"the",
"NCDS",
"and",
"NPAPH",
"as",
"national",
"initiatives",
"for",
"achieving",
"improvements",
"to",
"the",
"prevention",
"of",
"chronic",
"disease",
".What",
"are",
"the",
"implications",
"for",
"practitioners?",
"By",
"better",
"understanding",
"how",
"previous",
"countrywide",
"chronic",
"disease",
"initiatives",
"were",
"viewed",
"and",
"used",
"at",
"national,",
"state",
"and",
"local",
"levels,",
"this",
"research",
"is",
"well",
"placed",
"to",
"inform",
"current,",
"planned",
"and",
"future",
"large-scale,",
"population-level",
"health",
"initiatives."
] | [
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1,
1,
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1,
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1,
2,
2,
2,
0,
0,
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0,
0,
0,
0,
0,
1,
0,
1,
0,
1,
2,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
1,
2,
1,
0,
0,
0,
0,
0,
1,
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0,
0,
0,
0,
0,
1,
2,
2
] |
[
"Directed",
"Functional",
"Networks",
"in",
"Alzheimer's",
"Disease:",
"Disruption",
"of",
"Global",
"and",
"Local",
"Connectivity",
"Measures",
"Techniques",
"available",
"in",
"graph",
"theory",
"can",
"be",
"applied",
"to",
"signals",
"recorded",
"from",
"human",
"brain.",
"In",
"network",
"analysis",
"of",
"EEG",
"signals,",
"the",
"individual",
"nodes",
"are",
"EEG",
"sensor",
"locations",
"and",
"the",
"edges",
"correspond",
"to",
"functional",
"relations",
"between",
"them",
"that",
"are",
"extracted",
"from",
"EEG",
"time",
"series.",
"In",
"this",
"work,",
"we",
"study",
"EEG",
"-based",
"directed",
"functional",
"networks",
"in",
"Alzheimer's",
"disease",
"(AD).",
"To",
"this",
"end,",
"directed",
"connectivity",
"matrices",
"of",
"25",
"AD",
"patients",
"and",
"26",
"healthy",
"subjects",
"are",
"processed",
"and",
"a",
"number",
"of",
"neurophysiologically",
"meaningful",
"graph",
"theory",
"metrics",
"are",
"studied.",
"Our",
"data",
"show",
"that",
"functional",
"networks",
"of",
"AD",
"brains",
"have",
"significantly",
"reduced",
"global",
"connectivity",
"in",
"alpha",
"and",
"beta",
"bands",
"(P",
"<",
"0.05).",
"The",
"AD",
"brains",
"have",
"significantly",
"higher",
"local",
"connectivity",
"than",
"healthy",
"controls",
"in",
"alpha",
"and",
"beta",
"bands.",
"This",
"decreased",
"profile",
"in",
"global",
"connectivity",
"can",
"be",
"linked",
"to",
"compensatory",
"increased",
"local",
"connectivity",
"as",
"a",
"result",
"of",
"widespread",
"decline",
"in",
"the",
"long-range",
"connections.",
"We",
"also",
"study",
"resiliency",
"of",
"brain",
"networks",
"against",
"targeted",
"attack",
"to",
"hub",
"nodes",
"and",
"find",
"that",
"AD",
"networks",
"are",
"less",
"resilient",
"than",
"healthy",
"brains",
"in",
"alpha",
"and",
"beta",
"bands."
] | [
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] |
[
"Assessment",
"of",
"Interleukin-17A,",
"Interleukin-10",
"and",
"Transforming",
"Growth",
"Factor-Beta1",
"Serum",
"Titers",
"in",
"Relapsing",
"Remitting",
"Multiple",
"Sclerosis",
"Patients",
"Treated",
"with",
"Avonex,",
"Possible",
"Biomarkers",
"for",
"Treatment",
"Response",
"Individual",
"response",
"to",
"interferon",
"beta",
"(IFN-β)",
"1a",
"treatment",
"is",
"heterogeneous",
"in",
"multiple",
"sclerosis",
"(MS).",
"Our",
"objective",
"was",
"to",
"find",
"a",
"connection",
"between",
"serum",
"levels",
"of",
"interleukin",
"(IL)-10,",
"IL-17",
"and",
"transforming",
"growth",
"factor",
"beta",
"(TGF-β)1",
"in",
"MS",
"patients",
"treated",
"with",
"IFN-β",
"in",
"order",
"to",
"identify",
"the",
"nonresponders",
"(NR).",
"We",
"included",
"in",
"the",
"study",
"32",
"healthy",
"subjects",
"and",
"32",
"MS",
"patients:",
"10",
"naive,",
"10",
"early",
"treated",
"and",
"12",
"late",
"treated",
"with",
"INF-β1a.",
"Serum",
"determination",
"of",
"cytokines",
"and",
"brain",
"MRI",
"were",
"performed",
"at",
"the",
"beginning",
"of",
"the",
"study,",
"after",
"6",
"and",
"12",
"months.",
"Rio",
"score",
"was",
"calculated",
"at",
"the",
"end",
"of",
"the",
"study.",
"MS",
"patients",
"had",
"initially",
"a",
"significant",
"higher",
"level",
"of",
"IL-17",
"and",
"a",
"lower",
"level",
"of",
"TGF-β1",
"compared",
"to",
"healthy",
"subjects.",
"IL-17",
"level",
"in",
"early",
"treated",
"patients",
"was",
"significantly",
"lower",
"compared",
"to",
"the",
"naive",
"and",
"late",
"treated",
"groups.",
"INF-β1a",
"treatment",
"significantly",
"increased",
"IL-10",
"and",
"decreased",
"IL-17",
"levels.",
"Initial",
"low",
"levels",
"of",
"IL-10",
"were",
"associated",
"with",
"an",
"increase",
"in",
"physical",
"disability.",
"IL-17",
"levels",
"positively",
"correlated",
"with",
"the",
"number",
"of",
"relapses",
"and",
"MRI",
"activity.",
"Nine",
"patients",
"were",
"NR",
"to",
"Avonex.",
"Patients",
"with",
"a",
"Rio",
"score",
"of",
"3",
"had",
"higher",
"initial",
"levels",
"of",
"IL-17",
"and",
"those",
"with",
"a",
"Rio",
"score",
"of",
"0",
"had",
"higher",
"initial",
"levels",
"of",
"IL-10",
"and",
"TGF-β1.",
"IFN-β1a",
"decreased",
"IL-17",
"and",
"increased",
"IL-10",
"seric",
"levels;",
"IL-17",
"significantly",
"correlated",
"with",
"MS",
"activity;",
"TGF-β1",
"activity",
"is",
"titer-dependent,",
"increased",
"levels",
"were",
"associated",
"with",
"IL-17",
"inhibition;",
"NR",
"patients",
"to",
"IFN-β1a",
"will",
"have",
"initial",
"high",
"IL-17",
"and",
"low",
"IL-10",
"and",
"TGF-β",
"seric",
"levels."
] | [
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1,
0,
1,
1,
1,
1,
1,
1,
2,
0,
1,
1,
1,
1,
0,
1,
1,
1,
0,
1,
2,
1,
1,
1,
1,
0,
1,
0,
0,
1,
1,
1,
0,
1,
1,
0,
1,
1,
1
] |
[
"Cardiovascular",
"magnetic",
"resonance",
"features",
"of",
"mechanical",
"dyssynchrony",
"in",
"patients",
"with",
"left",
"bundle",
"branch",
"block",
"Patients",
"with",
"left",
"bundle",
"branch",
"block",
"(LBBB)",
"can",
"exhibit",
"mechanical",
"dyssynchrony",
"which",
"may",
"contribute",
"to",
"heart",
"failure;",
"such",
"patients",
"may",
"benefit",
"from",
"cardiac",
"resynchronization",
"treatment",
"(CRT).",
"While",
"cardiac",
"magnetic",
"resonance",
"imaging",
"(CMR)",
"has",
"become",
"a",
"common",
"part",
"of",
"heart",
"failure",
"work-up,",
"CMR",
"features",
"of",
"mechanical",
"dyssynchrony",
"in",
"patients",
"with",
"LBBB",
"have",
"not",
"been",
"well",
"characterized.",
"This",
"study",
"aims",
"to",
"investigate",
"the",
"potential",
"of",
"CMR",
"to",
"characterize",
"mechanical",
"features",
"of",
"LBBB.",
"CMR",
"examinations",
"from",
"43",
"patients",
"with",
"LBBB",
"on",
"their",
"electrocardiogram,",
"but",
"without",
"significant",
"focal",
"structural",
"abnormalities,",
"and",
"from",
"43",
"age-",
"and",
"gender",
"-matched",
"normal",
"controls",
"were",
"retrospectively",
"reviewed.",
"The",
"following",
"mechanical",
"features",
"of",
"LBBB",
"were",
"evaluated:",
"septal",
"flash",
"(SF),",
"apical",
"rocking",
"(AR),",
"delayed",
"aortic",
"valve",
"opening",
"measured",
"relative",
"to",
"both",
"end-diastole",
"(AVOED)",
"and",
"pulmonic",
"valve",
"opening",
"(AVOPVO),",
"delayed",
"left-ventricular",
"(LV)",
"free-wall",
"contraction,",
"and",
"curvatures",
"of",
"the",
"septum",
"and",
"LV",
"free-wall.",
"Septal",
"displacement",
"curves",
"were",
"also",
"generated,",
"using",
"feature",
"-tracking",
"techniques.",
"The",
"echocardiographic",
"findings",
"of",
"LBBB",
"were",
"also",
"reviewed",
"in",
"those",
"subjects",
"for",
"whom",
"they",
"were",
"available.",
"LBBB",
"was",
"significantly",
"associated",
"with",
"the",
"presence",
"of",
"SF",
"and",
"AR;",
"within",
"the",
"LBBB",
"group,",
"79",
"%",
"had",
"SF",
"and",
"65",
"%",
"had",
"AR.",
"Delayed",
"AVOED,",
"AVOPVO,",
"and",
"delayed",
"LV",
"free-wall",
"contraction",
"were",
"significantly",
"associated",
"with",
"LBBB.",
"AVOED",
"and",
"AVOPVO",
"positively",
"correlated",
"with",
"QRS",
"duration",
"and",
"negatively",
"correlated",
"with",
"ejection",
"fraction.",
"Hearts",
"with",
"electrocardiographic",
"evidence",
"of",
"LBBB",
"showed",
"lower",
"septal-to-LV",
"free-wall",
"curvature",
"ratios",
"at",
"end-diastole",
"compared",
"to",
"normal",
"controls.",
"CMR",
"can",
"be",
"used",
"to",
"identify",
"and",
"evaluate",
"mechanical",
"dyssynchrony",
"in",
"patients",
"with",
"LBBB.",
"None",
"of",
"the",
"normal",
"controls",
"showed",
"the",
"mechanical",
"features",
"associated",
"with",
"LBBB.",
"Moreover,",
"not",
"all",
"patients",
"with",
"LBBB",
"showed",
"the",
"same",
"degree",
"of",
"mechanical",
"dyssynchrony,",
"which",
"could",
"have",
"implications",
"for",
"CRT."
] | [
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] |
[
"Delayed",
"progression",
"of",
"rabies",
"transmitted",
"by",
"a",
"vampire",
"bat",
"Here,",
"we",
"compared",
"the",
"growth",
"kinetics,",
"cell-to-cell",
"spread,",
"and",
"virus",
"internalization",
"kinetics",
"in",
"N2a",
"cells",
"of",
"RABV",
"variants",
"isolated",
"from",
"vampire",
"bats",
"(V-3),",
"domestic",
"dogs",
"(V-2)",
"and",
"marmosets",
"(V-M)",
"as",
"well",
"as",
"the",
"clinical",
"symptoms",
"and",
"mortality",
"caused",
"by",
"these",
"variants.",
"The",
"replication",
"rate",
"of",
"V-3",
"was",
"significantly",
"higher",
"than",
"those",
"of",
"V-2",
"and",
"V-M.",
"However,",
"the",
"uptake",
"and",
"spread",
"of",
"these",
"RABV",
"variants",
"into",
"N2a",
"cells",
"were",
"inversely",
"proportional.",
"Nevertheless,",
"V-3",
"had",
"longer",
"incubation",
"and",
"evolution",
"periods.",
"Our",
"results",
"provide",
"evidence",
"that",
"the",
"clinical",
"manifestations",
"of",
"infection",
"with",
"bat",
"RABV",
"variant",
"occur",
"at",
"a",
"later",
"time",
"when",
"compared",
"to",
"what",
"was",
"observed",
"with",
"canine",
"and",
"marmoset",
"rabies",
"virus",
"variants."
] | [
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[
"SHOT",
"-",
"RNAs:",
"A",
"novel",
"class",
"of",
"tRNA",
"-derived",
"functional",
"RNAs",
"expressed",
"in",
"hormone-dependent",
"cancers",
"Sex",
"hormones",
"and",
"their",
"receptors",
"play",
"critical",
"roles",
"in",
"the",
"genesis",
"and",
"progression",
"of",
"breast",
"and",
"prostate",
"cancers.",
"We",
"recently",
"discovered",
"that",
"sex",
"hormone",
"signaling",
"pathways",
"promote",
"the",
"expression",
"of",
"specific",
"tRNA",
"halves",
"termed",
"Sex",
"HOrmone",
"-dependent",
"TRNA",
"-derived",
"RNAs",
"(SHOT",
"-",
"RNAs).",
"Functional",
"involvement",
"of",
"SHOT",
"-",
"RNAs",
"in",
"cell",
"proliferation",
"suggests",
"a",
"novel",
"tRNA",
"-engaged",
"pathway",
"in",
"tumorigenesis."
] | [
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[
"Upstream",
"Pathways",
"Controlling",
"Mitochondrial",
"Function",
"in",
"Major",
"Psychosis:",
"A",
"Focus",
"on",
"Bipolar",
"Disorder",
"Mitochondrial",
"dysfunction",
"is",
"commonly",
"observed",
"in",
"bipolar",
"disorder",
"(BD)",
"and",
"schizophrenia",
"(SCZ)",
"and",
"may",
"be",
"a",
"central",
"feature",
"of",
"psychosis.",
"These",
"illnesses",
"are",
"complex",
"and",
"heterogeneous,",
"which",
"is",
"reflected",
"by",
"the",
"complexity",
"of",
"the",
"processes",
"regulating",
"mitochondrial",
"function.",
"Mitochondria",
"are",
"typically",
"associated",
"with",
"energy",
"production;",
"however,",
"dysfunction",
"of",
"mitochondria",
"affects",
"not",
"only",
"energy",
"production",
"but",
"also",
"vital",
"cellular",
"processes,",
"including",
"the",
"formation",
"of",
"reactive",
"oxygen",
"species,",
"cell",
"cycle",
"and",
"survival,",
"intracellular",
"Ca(2+)",
"homeostasis,",
"and",
"neurotransmission.",
"In",
"this",
"review,",
"we",
"characterize",
"the",
"upstream",
"components",
"controlling",
"mitochondrial",
"function,",
"including",
"1)",
"mutations",
"in",
"nuclear",
"and",
"mitochondrial",
"DNA,",
"2)",
"mitochondrial",
"dynamics,",
"and",
"3)",
"intracellular",
"Ca(2+)",
"homeostasis.",
"Characterizing",
"and",
"understanding",
"the",
"upstream",
"factors",
"that",
"regulate",
"mitochondrial",
"function",
"is",
"essential",
"to",
"understand",
"progression",
"of",
"these",
"illnesses",
"and",
"develop",
"biomarkers",
"and",
"therapeutics."
] | [
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[
"The",
"Origin",
"of",
"Selectivity",
"in",
"the",
"Complexation",
"of",
"N-Methyl",
"Amino",
"Acids",
"by",
"Tetraphosphonate",
"Cavitands",
"We",
"report",
"on",
"the",
"eligibility",
"of",
"tetraphosphonate",
"resorcinarene",
"cavitands",
"for",
"the",
"molecular",
"recognition",
"of",
"amino",
"acids.",
"We",
"determined",
"the",
"crystal",
"structure",
"of",
"13",
"complexes",
"of",
"the",
"tetraphosphonate",
"cavitand",
"Tiiii[H,",
"CH3,",
"CH3]",
"with",
"amino",
"acids.",
"(1)",
"H",
"NMR",
"and",
"(31)",
"P",
"NMR",
"experiments",
"and",
"ITC",
"analysis",
"were",
"performed",
"to",
"probe",
"the",
"binding",
"between",
"cavitand",
"Tiiii[C3H7,",
"CH3,",
"C2H5]",
"or",
"the",
"water",
"-",
"soluble",
"counterpart",
"Tiiii[C3H6Py(+)Cl(-),",
"CH3,",
"C2H5]",
"and",
"a",
"selection",
"of",
"representative",
"amino",
"acids.",
"The",
"reported",
"studies",
"and",
"results",
"allowed",
"us",
"(i)",
"to",
"highlight",
"the",
"noncovalent",
"interactions",
"involved",
"in",
"the",
"binding",
"event",
"in",
"each",
"case;",
"(ii)",
"to",
"investigate",
"the",
"ability",
"of",
"tetraphosphonate",
"cavitand",
"receptors",
"to",
"discriminate",
"between",
"the",
"different",
"amino",
"acids;",
"(iii)",
"to",
"calculate",
"the",
"Ka",
"values",
"of",
"the",
"different",
"complexes",
"formed",
"and",
"evaluate",
"the",
"thermodynamic",
"parameters",
"of",
"the",
"complexation",
"process,",
"dissecting",
"the",
"entropic",
"and",
"enthalpic",
"contributions;",
"and",
"(iv)",
"to",
"determine",
"the",
"solvent",
"influence",
"on",
"the",
"complexation",
"selectivity.",
"By",
"moving",
"from",
"methanol",
"to",
"water,",
"the",
"complexation",
"changed",
"from",
"entropy",
"driven",
"to",
"entropy",
"opposed,",
"leading",
"to",
"a",
"drop",
"of",
"almost",
"three",
"orders",
"in",
"the",
"magnitude",
"of",
"the",
"Ka.",
"However,",
"this",
"reduction",
"in",
"binding",
"affinity",
"is",
"associated",
"with",
"a",
"dramatic",
"increase",
"in",
"selectivity,",
"since",
"in",
"aqueous",
"solutions",
"only",
"N-methylated",
"amino",
"acids",
"are",
"effectively",
"recognized.",
"The",
"thermodynamic",
"profile",
"of",
"the",
"binding",
"does",
"not",
"change",
"in",
"PBS",
"solution.",
"The",
"pivotal",
"role",
"played",
"by",
"cation-π",
"interactions",
"is",
"demonstrated",
"by",
"the",
"linear",
"correlation",
"found",
"between",
"the",
"log",
"Ka",
"in",
"methanol",
"solution",
"and",
"the",
"depth",
"of",
"(+)N-CH3",
"cavity",
"inclusion",
"in",
"the",
"molecular",
"structures.",
"These",
"findings",
"are",
"relevant",
"for",
"the",
"potential",
"use",
"of",
"phosphonate",
"cavitands",
"as",
"synthetic",
"receptors",
"for",
"the",
"detection",
"of",
"epigenetic",
"modifications",
"of",
"histones",
"in",
"physiological",
"media."
] | [
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1,
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] |
[
"Computed",
"Tomography",
"Imaging",
"Features",
"and",
"Changes",
"in",
"Hemostatic",
"Agents",
"After",
"Laparoscopic",
"Partial",
"Nephrectomy",
"Urologists",
"and",
"radiologists",
"should",
"be",
"aware",
"of",
"the",
"CT",
"scan",
"appearance",
"of",
"laparoscopic",
"partial",
"nephrectomy",
"(LPN)",
"with",
"the",
"various",
"hemostatic",
"agents",
"since",
"they",
"may",
"confound",
"the",
"interpretation",
"of",
"these",
"radiographic",
"findings.",
"We",
"report",
"the",
"various",
"postoperative",
"CT",
"scan",
"appearance",
"and",
"changes",
"after",
"LPN.",
"We",
"reviewed",
"CT",
"scans",
"retrospectively",
"(within",
"3",
"months)",
"of",
"86",
"patients",
"who",
"underwent",
"LPN",
"using",
"various",
"hemostatic",
"agents",
"between",
"March",
"2008",
"and",
"July",
"2014.",
"We",
"analyzed",
"the",
"CT",
"findings",
"after",
"LPN,",
"including",
"postoperative",
"changes,",
"tumor",
"recurrence,",
"and",
"complications.",
"We",
"also",
"discuss",
"changes",
"in",
"abnormal",
"features,",
"such",
"as",
"mass-like",
"lesions",
"and",
"gas",
"formation,",
"on",
"follow-up",
"CT",
"scans.",
"To",
"categorize",
"the",
"postoperative",
"changes,",
"we",
"classified",
"them",
"according",
"to",
"their",
"specific",
"CT",
"findings:",
"(1)",
"a",
"combination",
"of",
"perinephric",
"stranding",
"and",
"postsurgical",
"fluid",
"collection",
"(n",
"=",
"46),",
"(2)",
"mass-like",
"lesions",
"(n",
"=",
"35),",
"(3)",
"a",
"parenchymal",
"defect",
"(n",
"=",
"2),",
"(4)",
"local",
"recurrence",
"at",
"the",
"surgical",
"site",
"(n",
"=",
"1),",
"(5)",
"a",
"large",
"hematoma",
"as",
"a",
"complication",
"after",
"LPN",
"(n",
"=",
"2),",
"(6)",
"gas",
"pockets,",
"which",
"may",
"be",
"a",
"response",
"to",
"postsurgical",
"fluid",
"collection",
"around",
"soft",
"tissue",
"(n",
"=",
"35),",
"(7)",
"fat",
"at",
"the",
"excision",
"site",
"(n",
"=",
"2;",
"Fig.",
"7),",
"and",
"(8)",
"contrast",
"extravasation",
"in",
"the",
"delayed",
"phase",
"(n",
"=",
"1).",
"Mass-like",
"lesions",
"were",
"visible",
"in",
"35",
"cases.",
"The",
"average",
"change",
"in",
"size",
"of",
"bolster",
"masses",
"was",
"-1.19",
"mm/month.",
"However,",
"the",
"overall",
"change",
"in",
"enhancement",
"of",
"mass-like",
"lesions",
"was",
"not",
"significant",
"over",
"time.",
"Foci",
"of",
"gas",
"were",
"noted",
"in",
"16",
"patients",
"at",
"the",
"resection",
"site",
"in",
"the",
"first",
"follow-up",
"period",
"(<3",
"months),",
"as",
"late",
"as",
"40",
"days",
"after",
"the",
"procedure.",
"Knowledge",
"of",
"CT",
"imaging",
"features",
"and",
"changes",
"in",
"hemostatic",
"agents",
"following",
"LPN",
"is",
"important",
"in",
"interpreting",
"postoperative",
"CT",
"scans,",
"as",
"postoperative",
"changes",
"can",
"be",
"confused",
"with",
"tumor",
"recurrence",
"and",
"can",
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"abscesses."
] | [
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[
"Incidence",
"of",
"an",
"Anomalous",
"Course",
"of",
"the",
"Palmar",
"Cutaneous",
"Branch",
"of",
"the",
"Median",
"Nerve",
"During",
"Volar",
"Plate",
"Fixation",
"of",
"Distal",
"Radius",
"Fractures",
"Volar",
"plating",
"of",
"distal",
"radius",
"fractures",
"using",
"an",
"approach",
"through",
"the",
"flexor",
"carpi",
"radialis",
"(FCR)",
"sheath",
"is",
"commonplace.",
"The",
"palmar",
"cutaneous",
"branch",
"of",
"the",
"median",
"nerve",
"(PCB)",
"is",
"considered",
"to",
"run",
"in",
"a",
"position",
"adjacent",
"to,",
"but",
"outside,",
"the",
"ulnar",
"FCR",
"sheath.",
"Anatomic",
"studies",
"have",
"not",
"identified",
"anatomic",
"abnormalities",
"relevant",
"to",
"volar",
"plating.",
"The",
"purpose",
"of",
"this",
"study",
"was",
"to",
"determine",
"the",
"frequency",
"of",
"anomalous",
"PCB",
"branches",
"entering",
"the",
"FCR",
"sheath",
"during",
"volar",
"plating.",
"This",
"observational",
"study",
"involved",
"10",
"attending",
"hand",
"surgeons",
"during",
"a",
"7-",
"month",
"period",
"(July",
"2015-",
"January",
"2016).",
"Surgeons",
"assessed,",
"documented,",
"and",
"reported",
"any",
"PCB",
"anomalies",
"that",
"were",
"encountered",
"during",
"volar",
"plating",
"through",
"a",
"trans-",
"FCR",
"approach.",
"There",
"were",
"182",
"volar",
"plates",
"applied",
"that",
"made",
"up",
"the",
"study",
"group.",
"There",
"were",
"10",
"cases",
"(5.5%)",
"of",
"anomalous",
"PCBs",
"entering",
"the",
"FCR",
"sheath.",
"In",
"4",
"cases,",
"the",
"PCB",
"pierced",
"the",
"radial",
"FCR",
"sheath",
"proximally,",
"crossed",
"beneath",
"the",
"tendon,",
"and",
"traveled",
"distally",
"on",
"the",
"ulnar",
"side.",
"In",
"4",
"other",
"cases,",
"the",
"PCB",
"entered",
"the",
"FCR",
"sheath",
"proximally",
"on",
"the",
"ulnar",
"or",
"central",
"aspect",
"of",
"the",
"sheath",
"and",
"remained",
"within",
"the",
"sheath,",
"staying",
"along",
"the",
"ulnar",
"or",
"dorsal",
"side",
"of",
"the",
"tendon.",
"In",
"1",
"case,",
"the",
"PCB",
"pierced",
"the",
"ulnar",
"distal",
"aspect",
"of",
"the",
"sheath",
"and",
"split",
"into",
"2",
"branches.",
"In",
"1",
"case,",
"the",
"PCB",
"ran",
"within",
"the",
"sheath",
"along",
"the",
"radial",
"aspect",
"of",
"the",
"FCR.",
"Anomalies",
"in",
"the",
"course",
"of",
"the",
"PCB",
"are",
"more",
"common",
"than",
"often",
"considered.",
"These",
"variants",
"are",
"at",
"risk",
"during",
"volar",
"surgical",
"approaches",
"to",
"the",
"wrist",
"that",
"proceed",
"through",
"the",
"FCR",
"sheath.",
"Although",
"dissecting",
"along",
"the",
"radial",
"side",
"of",
"the",
"FCR",
"sheath",
"may",
"protect",
"the",
"PCB",
"in",
"most",
"cases,",
"care",
"must",
"be",
"taken",
"to",
"identify",
"anomalous",
"branches",
"(if",
"present)",
"and",
"protect",
"them",
"during",
"surgery."
] | [
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[
"Individualizing",
"drug",
"dosage",
"with",
"longitudinal",
"data",
"We",
"propose",
"a",
"two-step",
"procedure",
"to",
"personalize",
"drug",
"dosage",
"over",
"time",
"under",
"the",
"framework",
"of",
"a",
"log-linear",
"mixed-effect",
"model.",
"We",
"model",
"patients",
"'",
"heterogeneity",
"using",
"subject",
"-",
"specific",
"random",
"effects,",
"which",
"are",
"treated",
"as",
"the",
"realizations",
"of",
"an",
"unspecified",
"stochastic",
"process.",
"We",
"extend",
"the",
"conditional",
"quadratic",
"inference",
"function",
"to",
"estimate",
"both",
"fixed-effect",
"coefficients",
"and",
"individual",
"random",
"effects",
"on",
"a",
"longitudinal",
"training",
"data",
"sample",
"in",
"the",
"first",
"step",
"and",
"propose",
"an",
"adaptive",
"procedure",
"to",
"estimate",
"new",
"patients",
"'",
"random",
"effects",
"and",
"provide",
"dosage",
"recommendations",
"for",
"new",
"patients",
"in",
"the",
"second",
"step.",
"An",
"advantage",
"of",
"our",
"approach",
"is",
"that",
"we",
"do",
"not",
"impose",
"any",
"distribution",
"assumption",
"on",
"estimating",
"random",
"effects.",
"Moreover,",
"the",
"new",
"approach",
"can",
"accommodate",
"more",
"general",
"time",
"-varying",
"covariates",
"corresponding",
"to",
"random",
"effects.",
"We",
"show",
"in",
"theory",
"and",
"numerical",
"studies",
"that",
"the",
"proposed",
"method",
"is",
"more",
"efficient",
"compared",
"with",
"existing",
"approaches,",
"especially",
"when",
"covariates",
"are",
"time",
"varying.",
"In",
"addition,",
"a",
"real",
"data",
"example",
"of",
"a",
"clozapine",
"study",
"confirms",
"that",
"our",
"two-step",
"procedure",
"leads",
"to",
"more",
"accurate",
"drug",
"dosage",
"recommendations.",
"Copyright",
"©",
"2016",
"John",
"Wiley",
"&",
"Sons,",
"Ltd."
] | [
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[
"Association",
"of",
"Low",
"Ficolin",
"-",
"Lectin",
"Pathway",
"Parameters",
"with",
"Cardiac",
"Syndrome",
"X",
"In",
"patients",
"with",
"typical",
"angina",
"pectoris,",
"inducible",
"myocardial",
"ischaemia",
"and",
"macroscopically",
"normal",
"coronaries",
"(cardiac",
"syndrome",
"X",
"(CSX)),",
"a",
"significantly",
"elevated",
"plasma",
"level",
"of",
"terminal",
"complement",
"complex",
"(TCC),",
"the",
"common",
"end",
"product",
"of",
"complement",
"activation,",
"has",
"been",
"observed",
"without",
"accompanying",
"activation",
"of",
"the",
"classical",
"or",
"the",
"alternative",
"pathways.",
"Therefore,",
"our",
"aim",
"was",
"to",
"clarify",
"the",
"role",
"of",
"the",
"ficolin",
"-",
"lectin",
"pathway",
"in",
"CSX.",
"Eighteen",
"patients",
"with",
"CSX,",
"37",
"stable",
"angina",
"patients",
"with",
"significant",
"coronary",
"stenosis",
"(CHD)",
"and",
"54",
"healthy",
"volunteers",
"(HC)",
"were",
"enrolled.",
"Serum",
"levels",
"of",
"ficolin-2",
"and",
"ficolin-3,",
"ficolin-3",
"/",
"MASP-2",
"complex",
"and",
"ficolin-3",
"-mediated",
"TCC",
"deposition",
"(FCN3",
"-",
"TCC)",
"were",
"determined.",
"Plasma",
"level",
"of",
"TCC",
"was",
"significantly",
"higher",
"in",
"the",
"CSX",
"than",
"in",
"the",
"HC",
"or",
"CHD",
"group",
"(5.45",
"versus",
"1.30",
"versus",
"2.04",
"AU/ml,",
"P",
"<",
"0.001).",
"Serum",
"levels",
"of",
"ficolin-2",
"and",
"ficolin-3",
"were",
"significantly",
"lower",
"in",
"the",
"CSX",
"compared",
"to",
"the",
"HC",
"or",
"CHD",
"group",
"(3.60",
"versus",
"5.80",
"or",
"5.20",
"μg/ml,",
"P",
"<",
"0.05;",
"17.80",
"versus",
"24.10",
"or",
"26.80",
"μg/ml,",
"P",
"<",
"0.05).",
"The",
"ficolin-3",
"/",
"MASP-2",
"complex",
"was",
"significantly",
"lower",
"in",
"the",
"CSX",
"group",
"compared",
"to",
"the",
"HC",
"group",
"(92.90",
"versus",
"144.90",
"AU/ml,",
"P",
"=",
"0.006).",
"FCN3",
"-",
"TCC",
"deposition",
"was",
"significantly",
"lower",
"in",
"the",
"CSX",
"group",
"compared",
"to",
"the",
"HC",
"and",
"CHD",
"groups",
"(67.8%",
"versus",
"143.3%",
"or",
"159.7%,",
"P",
"<",
"0.05).",
"In",
"the",
"CSX",
"group,",
"a",
"significant",
"correlation",
"was",
"found",
"between",
"TCC",
"and",
"FCN3",
"-",
"TCC",
"level",
"(r",
"=",
"0.507,",
"P",
"=",
"0.032)",
"and",
"between",
"ficolin-3",
"/",
"MASP-2",
"complex",
"level",
"and",
"FCN3",
"-",
"TCC",
"deposition",
"(r",
"=",
"0.651,",
"P",
"=",
"0.003).",
"In",
"conclusion,",
"in",
"patients",
"with",
"typical",
"angina",
"and",
"myocardial",
"ischaemia",
"despite",
"macroscopically",
"normal",
"coronary",
"arteries,",
"low",
"levels",
"of",
"several",
"lectin",
"pathway",
"parameters",
"were",
"observed,",
"indicating",
"complement",
"activation",
"and",
"consumption.",
"Complement",
"activation",
"through",
"the",
"ficolin",
"-",
"lectin",
"pathway",
"might",
"play",
"a",
"role",
"in",
"the",
"complex",
"pathomechanism",
"of",
"CSX."
] | [
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[
"Specialized",
"morphology",
"corresponds",
"to",
"a",
"generalist",
"diet:",
"linking",
"form",
"and",
"function",
"in",
"smashing",
"mantis",
"shrimp",
"crustaceans",
"Many",
"animals",
"are",
"considered",
"to",
"be",
"specialists",
"because",
"they",
"have",
"feeding",
"structures",
"that",
"are",
"fine-tuned",
"for",
"consuming",
"specific",
"prey.",
"For",
"example,",
"\"smasher\"",
"mantis",
"shrimp",
"have",
"highly",
"specialized",
"predatory",
"appendages",
"that",
"generate",
"forceful",
"strikes",
"to",
"break",
"apart",
"hard-shelled",
"prey.",
"Anecdotal",
"observations",
"suggest,",
"however,",
"that",
"the",
"diet",
"of",
"smashers",
"may",
"include",
"soft-bodied",
"prey",
"as",
"well.",
"Our",
"goal",
"was",
"to",
"examine",
"the",
"diet",
"breadth",
"of",
"the",
"smasher",
"mantis",
"shrimp,",
"Neogonodactylus",
"bredini,",
"to",
"determine",
"whether",
"it",
"has",
"a",
"narrow",
"diet",
"of",
"hard-shelled",
"prey.",
"We",
"combined",
"studies",
"of",
"prey",
"abundance,",
"feeding",
"behavior,",
"and",
"stable",
"isotope",
"analyses",
"of",
"diet",
"in",
"both",
"seagrass",
"and",
"coral",
"rubble",
"to",
"determine",
"if",
"N.",
"bredini's",
"diet",
"was",
"consistent",
"across",
"different",
"habitat",
"types.",
"The",
"abundances",
"of",
"hard-shelled",
"and",
"soft-bodied",
"prey",
"varied",
"between",
"habitats.",
"In",
"feeding",
"experiments,",
"N.",
"bredini",
"consumed",
"both",
"prey",
"types.",
"N.",
"bredini",
"consumed",
"a",
"range",
"of",
"different",
"prey",
"in",
"the",
"field",
"as",
"well",
"and,",
"unexpectedly,",
"the",
"stable",
"isotope",
"analysis",
"demonstrated",
"that",
"soft-bodied",
"prey",
"comprised",
"a",
"large",
"proportion",
"(29-53",
"%)",
"of",
"the",
"diet",
"in",
"both",
"habitats.",
"Using",
"a",
"Bayesian",
"mixing",
"model",
"framework",
"(MixSIAR),",
"we",
"found",
"that",
"this",
"result",
"held",
"even",
"when",
"we",
"used",
"uninformative,",
"or",
"generalist,",
"priors",
"and",
"informative",
"priors",
"reflecting",
"a",
"specialist",
"diet",
"on",
"hard-shelled",
"prey",
"and",
"prey",
"abundances",
"in",
"the",
"field.",
"Thus,",
"contrary",
"to",
"expectation,",
"the",
"specialized",
"feeding",
"morphology",
"of",
"N.",
"bredini",
"corresponds",
"to",
"a",
"broad",
"diet",
"of",
"both",
"hard-shelled",
"and",
"soft-bodied",
"prey.",
"Using",
"multiple",
"lines",
"of",
"study",
"to",
"describe",
"the",
"natural",
"diets",
"of",
"other",
"presumed",
"specialists",
"may",
"demonstrate",
"that",
"specialized",
"morphology",
"often",
"broadens",
"rather",
"than",
"narrows",
"diet",
"breadth."
] | [
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[
"Toxicity",
"assessment",
"of",
"water-accommodated",
"fractions",
"from",
"two",
"different",
"oils",
"using",
"a",
"zebrafish",
"(Danio",
"rerio)",
"embryo",
"-",
"larval",
"bioassay",
"with",
"a",
"multilevel",
"approach",
"Petroleum",
"compounds",
"from",
"chronic",
"discharges",
"and",
"oil",
"spills",
"represent",
"an",
"important",
"source",
"of",
"environmental",
"pollution.",
"To",
"better",
"understand",
"the",
"deleterious",
"effects",
"of",
"these",
"compounds,",
"the",
"toxicity",
"of",
"water-accommodated",
"fractions",
"(WAF)",
"from",
"two",
"different",
"oils",
"(brut",
"Arabian",
"Light",
"and",
"Erika",
"heavy",
"fuel",
"oils)",
"were",
"used",
"in",
"this",
"study.",
"Zebrafish",
"embryos",
"(Danio",
"rerio)",
"were",
"exposed",
"during",
"96",
"h",
"at",
"three",
"WAF",
"concentrations",
"(1,",
"10",
"and",
"100%",
"for",
"Arabian",
"Light",
"and",
"10,",
"50",
"and",
"100%",
"for",
"Erika)",
"in",
"order",
"to",
"cover",
"a",
"wide",
"range",
"of",
"polycyclic",
"aromatic",
"hydrocarbon",
"(PAH)",
"concentrations,",
"representative",
"of",
"the",
"levels",
"found",
"after",
"environmental",
"oil",
"spills.",
"Several",
"endpoints",
"were",
"recorded",
"at",
"different",
"levels",
"of",
"biological",
"organization,",
"including",
"lethal",
"endpoints,",
"morphological",
"abnormalities,",
"photomotor",
"behavioral",
"responses,",
"cardiac",
"activity,",
"DNA",
"damage",
"and",
"exposure",
"level",
"measurements",
"(EROD",
"activity,",
"cyp1a",
"and",
"PAH",
"metabolites).",
"Neither",
"morphological",
"nor",
"behavioral",
"or",
"physiological",
"alterations",
"were",
"observed",
"after",
"exposure",
"to",
"Arabian",
"Light",
"fractions.",
"In",
"contrast,",
"the",
"Erika",
"fractions",
"led",
"a",
"high",
"degree",
"of",
"toxicity",
"in",
"early",
"life",
"stages",
"of",
"zebrafish.",
"Despite",
"of",
"defense",
"mechanisms",
"induced",
"by",
"oil,",
"acute",
"toxic",
"effects",
"have",
"been",
"recorded",
"including",
"mortality,",
"delayed",
"hatching,",
"high",
"rates",
"of",
"developmental",
"abnormalities,",
"disrupted",
"locomotor",
"activity",
"and",
"cardiac",
"failures",
"at",
"the",
"highest",
"PAH",
"concentrations",
"(∑TPAHs=257,029±47,231ng·L(-1)).",
"Such",
"differences",
"in",
"toxicity",
"are",
"likely",
"related",
"to",
"the",
"oil",
"composition.",
"The",
"use",
"of",
"developing",
"zebrafish",
"is",
"a",
"good",
"tool",
"to",
"identify",
"wide",
"range",
"of",
"detrimental",
"effects",
"and",
"elucidate",
"their",
"underlying",
"foundations.",
"Our",
"work",
"highlights",
"once",
"more,",
"the",
"cardiotoxic",
"action",
"(and",
"potentially",
"neurotoxic)",
"of",
"petroleum",
"-related",
"PAHs."
] | [
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[
"Evaluation",
"of",
"the",
"in",
"vitro",
"growth",
"of",
"urinary",
"tract",
"infection",
"-causing",
"gram-negative",
"and",
"gram-positive",
"bacteria",
"in",
"a",
"proposed",
"synthetic",
"human",
"urine",
"(SHU)",
"medium",
"Bacteriuria",
"is",
"a",
"hallmark",
"of",
"urinary",
"tract",
"infection",
"(UTI)",
"and",
"asymptomatic",
"bacteriuria",
"(ABU),",
"which",
"are",
"among",
"the",
"most",
"frequent",
"infections",
"in",
"humans.",
"A",
"variety",
"of",
"gram-negative",
"and",
"gram-positive",
"bacteria",
"are",
"associated",
"with",
"these",
"infections",
"but",
"Escherichia",
"coli",
"contributes",
"up",
"to",
"80%",
"of",
"cases.",
"Multiple",
"bacterial",
"species",
"including",
"E.",
"coli",
"can",
"grow",
"in",
"human",
"urine",
"as",
"a",
"means",
"to",
"maintain",
"colonization",
"during",
"infections.",
"In",
"vitro",
"bacteriuria",
"studies",
"aimed",
"at",
"modeling",
"microbial",
"growth",
"in",
"urine",
"have",
"utilized",
"various",
"compositions",
"of",
"synthetic",
"human",
"urine",
"(SHU)",
"and",
"a",
"Composite",
"SHU",
"formulation",
"was",
"recently",
"proposed.",
"In",
"this",
"study,",
"we",
"sought",
"to",
"validate",
"the",
"recently",
"proposed",
"Composite",
"SHU",
"as",
"a",
"medium",
"that",
"supports",
"the",
"growth",
"of",
"several",
"bacterial",
"species",
"that",
"are",
"known",
"to",
"grow",
"in",
"normal",
"human",
"urine",
"and/or",
"artificial",
"urine.",
"Comparative",
"growth",
"assays",
"of",
"gram-negative",
"and",
"gram-positive",
"bacteria",
"E.",
"coli,",
"Pseudomonas",
"aeruginosa,",
"Proteus",
"mirabilis,",
"Streptococcus",
"agalactiae,",
"Staphylococcus",
"saprophyticus",
"and",
"Enterococcus",
"faecalis",
"were",
"undertaken",
"using",
"viable",
"bacterial",
"count",
"and",
"optical",
"density",
"measurements",
"over",
"a",
"48h",
"culture",
"period.",
"Three",
"different",
"SHU",
"formulations",
"were",
"tested",
"in",
"various",
"culture",
"vessels,",
"shaking",
"conditions",
"and",
"volumes",
"and",
"showed",
"that",
"Composite",
"SHU",
"can",
"support",
"the",
"robust",
"growth",
"of",
"gram-negative",
"bacteria",
"but",
"requires",
"supplementation",
"with",
"0.2%",
"yeast",
"extract",
"to",
"support",
"the",
"growth",
"of",
"gram-positive",
"bacteria.",
"Experiments",
"are",
"also",
"presented",
"that",
"show",
"an",
"unexpected",
"but",
"major",
"influence",
"of",
"P.",
"mirabilis",
"towards",
"the",
"ability",
"to",
"measure",
"bacterial",
"growth",
"in",
"generally",
"accepted",
"multiwell",
"assays",
"using",
"absorbance",
"readings,",
"predicted",
"to",
"have",
"a",
"basis",
"in",
"the",
"release",
"of",
"volatile",
"organic",
"compound(s)",
"from",
"P.",
"mirabilis",
"during",
"growth",
"in",
"Composite",
"SHU",
"medium.",
"This",
"study",
"represents",
"an",
"essential",
"methodological",
"validation",
"of",
"a",
"more",
"chemically",
"defined",
"type",
"of",
"synthetic",
"urine",
"that",
"can",
"be",
"applied",
"to",
"study",
"mechanisms",
"of",
"bacteriuria",
"and",
"we",
"conclude",
"will",
"offer",
"a",
"useful",
"in",
"vitro",
"model",
"to",
"investigate",
"the",
"basis",
"of",
"some",
"of",
"the",
"most",
"common",
"infections",
"of",
"humans."
] | [
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1,
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1,
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1,
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1,
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1,
0,
0,
1,
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1,
0,
0,
1,
1,
1,
0,
0,
1,
1,
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0,
0,
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1,
1,
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1,
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0,
1,
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[
"Osteopontin",
"expression",
"in",
"co-cultures",
"of",
"human",
"squamous",
"cell",
"carcinoma",
"-derived",
"cells",
"and",
"osteoblastic",
"cells",
"and",
"its",
"effects",
"on",
"the",
"neoplastic",
"cell",
"phenotype",
"and",
"osteoclastic",
"activation",
"This",
"study",
"evaluated",
"the",
"temporal",
"expression",
"of",
"osteopontin",
"(OPN)",
"in",
"co-cultures",
"of",
"human",
"osteoblastic",
"cells",
"(SAOS-2)",
"and",
"oral",
"squamous",
"cell",
"carcinoma",
"(OSCC)-derived",
"cells",
"(SCC9)",
"and",
"examined",
"the",
"effects",
"of",
"osteoblast",
"-derived",
"OPN",
"on",
"the",
"neoplastic",
"cell",
"phenotype.",
"Additionally,",
"the",
"effects",
"of",
"these",
"co-cultures",
"on",
"subsequent",
"osteoclastic",
"activity",
"were",
"explored.",
"SCC9",
"cells",
"were",
"plated",
"on",
"Transwell®",
"membranes",
"that",
"were",
"either",
"coated",
"or",
"not",
"coated",
"with",
"Matrigel",
"and",
"were",
"then",
"co-cultured",
"with",
"SAOS-2",
"cells",
"during",
"the",
"peak",
"of",
"OPN",
"expression.",
"SCC9",
"cells",
"exposed",
"to",
"OPN",
"-silenced",
"SAOS-2",
"cultures",
"and",
"SCC9",
"cells",
"cultured",
"alone",
"served",
"as",
"controls.",
"SCC9",
"cells",
"were",
"quantitatively",
"evaluated",
"for",
"cell",
"adhesion,",
"proliferation,",
"migration,",
"and",
"invasion",
"into",
"Matrigel.",
"The",
"impact",
"of",
"co-culturing",
"SAOS-2",
"and",
"SCC9",
"cells",
"on",
"the",
"resorptive",
"capacity",
"of",
"U-937",
"-derived",
"osteoclastic",
"cells",
"was",
"also",
"investigated.",
"Furthermore,",
"a",
"reciprocal",
"induction",
"of",
"SAOS-2",
"and",
"SCC9",
"cells",
"in",
"terms",
"of",
"OPN",
"expression",
"over",
"the",
"co-culture",
"interval",
"was",
"identified.",
"SAOS-2",
"-secreted",
"OPN",
"altered",
"the",
"SCC9",
"cell",
"phenotype,",
"leading",
"to",
"enhanced",
"cell",
"adhesion",
"and",
"proliferation",
"and",
"higher",
"Matrigel",
"invasion.",
"This",
"invasion",
"was",
"also",
"enhanced,",
"albeit",
"to",
"a",
"lesser",
"degree,",
"by",
"co-culture",
"with",
"OPN",
"-",
"silenced",
"SAOS-2",
"cells.",
"Cell",
"migration",
"was",
"not",
"affected.",
"Co-culture",
"with",
"SAOS-2",
"cells",
"-mainly",
"during",
"the",
"period",
"of",
"peak",
"OPN",
"expression",
"-promoted",
"over-expression",
"of",
"IL-6",
"and",
"IL-8",
"by",
"SCC9",
"cells",
"and",
"enhanced",
"the",
"resorptive",
"capacity",
"of",
"osteoclastic",
"cells.",
"Taken",
"together,",
"these",
"results",
"suggest",
"that",
"osteoblast",
"-derived",
"OPN",
"affects",
"the",
"interactions",
"among",
"OSCC",
"-derived",
"epithelial",
"cells,",
"osteoblasts,",
"and",
"osteoclasts,",
"which",
"could",
"contribute",
"to",
"the",
"process",
"of",
"bone",
"destruction",
"during",
"bone",
"invasion",
"by",
"OSCC."
] | [
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1,
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1,
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1,
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1,
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1,
2,
0,
1,
1,
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1
] |
[
"Traumatic",
"Brain",
"Injury",
"Induces",
"Alterations",
"in",
"Cortical",
"Glutamate",
"Uptake",
"without",
"a",
"Reduction",
"in",
"Glutamate",
"Transporter-1",
"Protein",
"Expression",
"We",
"hypothesize",
"that",
"the",
"primary",
"mechanism",
"for",
"removal",
"of",
"glutamate",
"from",
"the",
"extracellular",
"space",
"is",
"altered",
"after",
"traumatic",
"brain",
"injury",
"(TBI).",
"To",
"evaluate",
"this",
"hypothesis,",
"we",
"initiated",
"TBI",
"in",
"adult",
"male",
"rats",
"using",
"a",
"2.0",
"atm",
"lateral",
"fluid",
"percussion",
"injury",
"(LFPI)",
"model.",
"In",
"the",
"ipsilateral",
"cortex",
"and",
"hippocampus,",
"we",
"found",
"no",
"differences",
"in",
"expression",
"of",
"the",
"primary",
"glutamate",
"transporter",
"in",
"the",
"brain",
"(GLT-1)",
"24",
"h",
"after",
"TBI.",
"In",
"contrast,",
"we",
"found",
"a",
"decrease",
"in",
"glutamate",
"uptake",
"in",
"the",
"cortex,",
"but",
"not",
"the",
"hippocampus,",
"24",
"h",
"after",
"injury.",
"Because",
"glutamate",
"uptake",
"is",
"potently",
"regulated",
"by",
"protein",
"kinases,",
"we",
"assessed",
"global",
"serine-threonine",
"protein",
"kinase",
"activity",
"using",
"a",
"kinome",
"array",
"platform.",
"Twenty-five",
"kinome",
"array",
"peptide",
"substrates",
"were",
"differentially",
"phoshorylated",
"between",
"LFPI",
"and",
"controls",
"in",
"the",
"cortex,",
"whereas",
"19",
"peptide",
"substrates",
"were",
"differentially",
"phosphorylated",
"in",
"the",
"hippocampus",
"(fold",
"change",
"≥",
"±",
"1.15).",
"We",
"identified",
"several",
"kinases",
"as",
"likely",
"to",
"be",
"involved",
"in",
"acute",
"TBI,",
"including",
"protein",
"kinase",
"B",
"(Akt)",
"and",
"protein",
"kinase",
"C",
"(PKC),",
"which",
"are",
"well-characterized",
"modulators",
"of",
"GLT-1.",
"Exploratory",
"studies",
"using",
"an",
"inhibitor",
"of",
"Akt",
"suggest",
"selective",
"activation",
"of",
"kinases",
"in",
"LFPI",
"versus",
"controls.",
"Ingenuity",
"pathway",
"analyses",
"of",
"implicated",
"kinases",
"from",
"our",
"network",
"model",
"found",
"apoptosis",
"and",
"cell",
"death",
"pathways",
"as",
"top",
"functions",
"in",
"acute",
"LFPI.",
"Taken",
"together,",
"our",
"data",
"suggest",
"diminished",
"activity",
"of",
"glutamate",
"transporters",
"in",
"the",
"prefrontal",
"cortex,",
"with",
"no",
"changes",
"in",
"protein",
"expression",
"of",
"the",
"primary",
"glutamate",
"transporter",
"GLT-1,",
"and",
"global",
"alteration",
"s",
"in",
"signaling",
"networks",
"that",
"include",
"serine-threonine",
"kinases",
"that",
"are",
"known",
"modulators",
"of",
"glutamate",
"transport",
"activity."
] | [
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[
"Ca(2+)",
"-",
"Clock-Dependent",
"Pacemaking",
"in",
"the",
"Sinus",
"Node",
"Is",
"Impaired",
"in",
"Mice",
"with",
"a",
"Cardiac",
"Specific",
"Reduction",
"in",
"SERCA2",
"Abundance",
"The",
"sarcoplasmic",
"reticulum",
"Ca(2+)-ATPase"
] | [
1,
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] |
[
"Frequency",
"of",
"BCR-ABL",
"Transcript",
"Types",
"in",
"Syrian",
"CML",
"Patients",
"Background.",
"In",
"Syria,",
"CML",
"patients",
"are",
"started",
"on",
"tyrosine",
"kinase",
"inhibitors",
"(TKIs)",
"and",
"monitored",
"until",
"complete",
"molecular",
"response",
"is",
"achieved.",
"BCR-ABL",
"mRNA",
"transcript",
"type",
"is",
"not",
"routinely",
"identified,",
"contrary",
"to",
"the",
"recommendations.",
"In",
"this",
"study",
"we",
"aimed",
"to",
"identify",
"the",
"frequency",
"of",
"different",
"BCR-ABL",
"transcripts",
"in",
"Syrian",
"CML",
"patients",
"and",
"highlight",
"their",
"significance",
"on",
"monitoring",
"and",
"treatment",
"protocols.",
"Methods.",
"CML",
"patients",
"positive",
"for",
"BCR-ABL",
"transcripts",
"by",
"quantitative",
"RT-PCR",
"were",
"enrolled.",
"BCR-ABL",
"transcript",
"types",
"were",
"investigated",
"using",
"a",
"home-made",
"PCR",
"method",
"that",
"was",
"adapted",
"from",
"published",
"protocols",
"and",
"optimized.",
"The",
"transcript",
"types",
"were",
"then",
"confirmed",
"using",
"a",
"commercially",
"available",
"research",
"kit.",
"Results.",
"Twenty-four",
"transcripts",
"were",
"found",
"in",
"21",
"patients.",
"The",
"most",
"common",
"was",
"b2a2,",
"followed",
"by",
"b3a2,",
"b3a3,",
"and",
"e1a3",
"present",
"solely",
"in",
"12",
"(57.1%),",
"3",
"(14.3%),",
"2",
"(9.5%),",
"and",
"1",
"(4.8%),",
"respectively.",
"Three",
"samples",
"(14.3%)",
"contained",
"dual",
"transcripts.",
"While",
"b3a2",
"transcript",
"was",
"apparently",
"associated",
"with",
"warning",
"molecular",
"response",
"to",
"imatinib",
"treatment,",
"b2a2,",
"b3a3,",
"and",
"e1a3",
"transcripts",
"collectively",
"proved",
"otherwise",
"(P",
"=",
"0.047).",
"Conclusion.",
"It",
"might",
"be",
"advisable",
"to",
"identify",
"the",
"BCR-ABL",
"transcript",
"type",
"in",
"CML",
"patients",
"at",
"diagnosis,",
"using",
"an",
"empirically",
"verified",
"method,",
"in",
"order",
"to",
"link",
"the",
"detected",
"transcript",
"with",
"the",
"clinical",
"findings,",
"possible",
"resistance",
"to",
"treatment,",
"and",
"appropriate",
"monitoring",
"methods."
] | [
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1,
1,
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[
"Steamed",
"and",
"Fermented",
"Ethanolic",
"Extract",
"from",
"Codonopsis",
"lanceolata",
"Attenuates",
"Amyloid-β",
"-",
"Induced",
"Memory",
"Impairment",
"in",
"Mice",
"Codonopsis",
"lanceolata",
"(C.",
"lanceolata)",
"is",
"a",
"traditional",
"medicinal",
"plant",
"used",
"for",
"the",
"treatment",
"of",
"certain",
"inflammatory",
"diseases",
"such",
"as",
"asthma,",
"tonsillitis,",
"and",
"pharyngitis.",
"We",
"evaluated",
"whether",
"steamed",
"and",
"fermented",
"C.",
"lanceolata",
"(SFC)",
"extract",
"improves",
"amyloid-β",
"-",
"(Aβ-)",
"induced",
"learning",
"and",
"memory",
"impairment",
"in",
"mice.",
"The",
"Morris",
"water",
"maze",
"and",
"passive",
"avoidance",
"tests",
"were",
"used",
"to",
"evaluate",
"the",
"effect",
"of",
"SFC",
"extract.",
"Moreover,",
"we",
"investigated",
"acetylcholinesterase",
"(AChE)",
"activity",
"and",
"brain-derived",
"neurotrophic",
"factor",
"(BDNF),",
"cyclic",
"AMP",
"response",
"element-binding",
"protein",
"(CREB),",
"and",
"extracellular",
"signal-regulated",
"kinase",
"(ERK)",
"signaling",
"in",
"the",
"hippocampus",
"of",
"mice",
"to",
"determine",
"a",
"possible",
"mechanism",
"for",
"the",
"cognitive",
"-",
"enhancing",
"effect.",
"Saponin",
"compounds",
"in",
"SFC",
"were",
"identified",
"by",
"Ultra",
"Performance",
"Liquid",
"Chromatography-Quadrupole-Time-of-Flight",
"Mass",
"Spectrometry",
"(UPLC-Q-TOF-MS).",
"SFC",
"extract",
"ameliorated",
"amyloid-β",
"-",
"induced",
"memory",
"impairment",
"in",
"the",
"Morris",
"water",
"maze",
"and",
"passive",
"avoidance",
"tests.",
"SFC",
"extract",
"inhibited",
"AChE",
"activity",
"and",
"also",
"significantly",
"increased",
"the",
"level",
"of",
"CREB",
"phosphorylation,",
"BDNF",
"expression,",
"and",
"ERK",
"activation",
"in",
"hippocampal",
"tissue",
"of",
"amyloid-β",
"-",
"treated",
"mice.",
"Lancemasides",
"A,",
"B,",
"C,",
"D,",
"E,",
"and",
"G",
"and",
"foetidissimoside",
"A",
"compounds",
"present",
"in",
"SFC",
"were",
"determined",
"by",
"UPLC-Q-TOF-MS.",
"These",
"results",
"indicate",
"that",
"SFC",
"extract",
"improves",
"Aβ",
"-",
"induced",
"memory",
"deficits",
"and",
"that",
"AChE",
"inhibition",
"and",
"CREB",
"/",
"BDNF",
"/",
"ERK",
"expression",
"is",
"important",
"for",
"the",
"effect",
"of",
"the",
"SFC",
"extract.",
"In",
"addition,",
"lancemaside",
"A",
"specifically",
"may",
"be",
"responsible",
"for",
"efficacious",
"effect",
"of",
"SFC."
] | [
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1,
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0,
1,
0,
0,
0,
1,
0,
1,
0,
0,
1,
2,
1,
1,
0,
1,
1,
2,
0,
0,
1,
1,
0,
1,
0,
1,
0,
1,
1,
0,
1,
0,
0,
1,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
1,
0,
1
] |
[
"Significance",
"of",
"ETV6",
"rearrangement",
"in",
"acute",
"promyelocytic",
"leukemia",
"with",
"t(15;17)/",
"promyelocytic",
"leukemia",
"/",
"retinoic",
"acid",
"receptor",
"alpha",
"Acute",
"promyelocytic",
"leukemia",
"(APL)",
"is",
"a",
"common",
"subtype",
"of",
"acute",
"myeloid",
"leukemia",
"in",
"China.",
"Since",
"the",
"application",
"of",
"arsenic",
"trioxide",
"and",
"all-trans",
"retinoic",
"acid",
"in",
"the",
"treatment",
"of",
"APL,",
"the",
"prognosis",
"has",
"greatly",
"improved.",
"However,",
"~20%",
"of",
"patients",
"with",
"APL",
"relapse",
"upon",
"completing",
"chemotherapy.",
"Decreasing",
"the",
"relapse",
"rate",
"and",
"incidence",
"of",
"early",
"mortality",
"may",
"pose",
"the",
"greatest",
"challenges",
"for",
"the",
"future",
"management",
"of",
"APL.",
"Recently,",
"Ets",
"variant",
"6",
"(ETV6)",
"was",
"reported",
"to",
"be",
"involved",
"in",
"a",
"variety",
"of",
"translocations",
"associated",
"with",
"hematological",
"malignancies",
"of",
"myeloid",
"and",
"lymphoid",
"origin.",
"To",
"date,",
"little",
"is",
"known",
"about",
"the",
"clinical",
"implication",
"of",
"ETV6",
"rearrangement",
"in",
"APL.",
"In",
"the",
"present",
"study,",
"ETV6",
"rearrangement",
"was",
"examined",
"by",
"split-signal",
"fluorescence",
"in",
"situ",
"hybridization",
"in",
"258",
"adults",
"with",
"APL,",
"and",
"its",
"association",
"with",
"the",
"clinical",
"features",
"and",
"outcomes",
"of",
"the",
"patients",
"was",
"analyzed.",
"The",
"data",
"suggested",
"that",
"ETV6",
"rearrangement",
"may",
"be",
"an",
"independent",
"unfavorable",
"prognostic",
"factor",
"for",
"overall",
"survival",
"in",
"APL",
"patients."
] | [
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[
"Early",
"Cognitive",
"Deficits",
"in",
"Type",
"2",
"Diabetes:",
"A",
"Population-Based",
"Study",
"Evidence",
"links",
"type",
"2",
"diabetes",
"to",
"dementia",
"risk.",
"However,",
"our",
"knowledge",
"on",
"the",
"initial",
"cognitive",
"deficits",
"in",
"diabetic",
"individuals",
"and",
"the",
"factors",
"that",
"might",
"promote",
"such",
"deficits",
"is",
"still",
"limited.",
"This",
"study",
"aimed",
"to",
"identify",
"the",
"cognitive",
"domains",
"initially",
"impaired",
"by",
"diabetes",
"and",
"the",
"factors",
"that",
"play",
"a",
"role",
"in",
"this",
"first",
"stage.",
"Within",
"the",
"population-based",
"Swedish",
"National",
"Study",
"on",
"Aging",
"and",
"Care-Kungsholmen,",
"2305",
"cognitively",
"intact",
"participants",
"aged",
"≥60",
"y",
"were",
"identified.",
"Attention",
"/",
"working",
"memory,",
"perceptual",
"speed,",
"category",
"fluency,",
"letter",
"fluency,",
"semantic",
"memory,",
"and",
"episodic",
"memory",
"were",
"assessed.",
"Diabetes",
"(controlled",
"and",
"uncontrolled)",
"and",
"prediabetes",
"were",
"ascertained",
"by",
"clinicians,",
"who",
"also",
"collected",
"information",
"on",
"vascular",
"disorders",
"(hypertension,",
"heart",
"diseases,",
"and",
"stroke)",
"and",
"vascular",
"risk",
"factors",
"(VRFs,",
"including",
"smoking",
"and",
"overweight",
"/",
"obesity).",
"Data",
"were",
"analyzed",
"with",
"linear",
"regression",
"models.",
"Overall,",
"196",
"participants",
"(8.5%)",
"had",
"diabetes,",
"of",
"which",
"144",
"(73.5%)",
"had",
"elevated",
"glycaemia",
"(uncontrolled",
"diabetes);",
"571",
"(24.8%)",
"persons",
"had",
"prediabetes.",
"In",
"addition,",
"diabetes,",
"mainly",
"uncontrolled,",
"was",
"related",
"to",
"lower",
"performance",
"in",
"perceptual",
"speed",
"(β",
"-",
"1.10",
"[95%",
"CI",
"-",
"1.98,",
"-",
"0.23]),",
"category",
"fluency",
"(β",
"-",
"1.27",
"[95%",
"CI",
"-",
"2.52,",
"-",
"0.03]),",
"and",
"digit",
"span",
"forward",
"(β",
"-",
"0.35",
"[95%",
"CI",
"-",
"0.54,",
"-",
"0.17]).",
"Critically,",
"these",
"associations",
"were",
"present",
"only",
"among",
"APOEɛ4",
"non-carriers.",
"The",
"associations",
"of",
"diabetes",
"with",
"perceptual",
"speed",
"and",
"category",
"fluency",
"were",
"present",
"only",
"among",
"participants",
"with",
"VRFs",
"or",
"vascular",
"disorders.",
"Diabetes,",
"especially",
"uncontrolled",
"diabetes,",
"is",
"associated",
"with",
"poorer",
"performance",
"in",
"perceptual",
"speed,",
"category",
"fluency,",
"and",
"attention",
"/",
"primary",
"memory.",
"VRFs,",
"vascular",
"disorders,",
"and",
"APOE",
"status",
"play",
"a",
"role",
"in",
"these",
"associations."
] | [
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1,
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1,
1,
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0,
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1,
1,
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1,
1,
1,
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0,
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1,
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1,
0,
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] |
[
"Functional",
"conservation",
"of",
"the",
"lncRNA",
"NEAT1",
"in",
"the",
"ancestrally",
"diverged",
"marsupial",
"lineage:",
"Evidence",
"for",
"NEAT1",
"expression",
"and",
"associated",
"paraspeckle",
"assembly",
"during",
"late",
"gestation",
"in",
"the",
"opossum",
"Monodelphis",
"domestica",
"Long",
"non-coding",
"RNAs",
"(lncRNAs)",
"are",
"widely",
"expressed",
"and",
"play",
"various",
"roles",
"in",
"cell",
"homeostasis.",
"However,",
"because",
"of",
"their",
"low",
"conservation",
"at",
"the",
"sequence",
"level,",
"recapitulating",
"lncRNA",
"evolutionary",
"history",
"is",
"often",
"challenging.",
"While",
"performing",
"an",
"ultrastructural",
"analysis",
"of",
"viral",
"particles",
"present",
"in",
"uterine",
"glands",
"of",
"gestating",
"opossum",
"females,",
"we",
"serendipitously",
"noticed",
"the",
"presence",
"of",
"numerous",
"structures",
"similar",
"to",
"paraspeckles,",
"nuclear",
"bodies",
"which",
"in",
"human",
"and",
"mouse",
"cells",
"are",
"assembled",
"around",
"an",
"architectural",
"NEAT1/MENϵ/β",
"lncRNA.",
"Here,",
"using",
"an",
"opossum",
"kidney",
"(OK)",
"cell",
"line,",
"we",
"confirmed",
"by",
"immuno-electron",
"microscopy",
"the",
"presence",
"of",
"paraspeckles",
"in",
"marsupials.",
"We",
"then",
"identified",
"the",
"orthologous",
"opossum",
"NEAT1",
"gene",
"which,",
"although",
"poorly",
"conserved",
"at",
"the",
"sequence",
"level,",
"displays",
"NEAT1",
"characteristic",
"features",
"such",
"as",
"short",
"and",
"long",
"isoforms",
"expressed",
"from",
"a",
"unique",
"promoter",
"and",
"for",
"the",
"latter",
"an",
"RNase",
"P",
"cleavage",
"site",
"at",
"its",
"3'-end.",
"Combining",
"tissue",
"-",
"specific",
"qRT-PCR,",
"in",
"situ",
"hybridization",
"at",
"the",
"optical",
"and",
"electron",
"microscopic",
"levels,",
"we",
"show",
"that",
"(i)",
"NEAT1",
"is",
"paraspeckle",
"-",
"associated",
"in",
"opossum",
"(ii)",
"NEAT1",
"expression",
"is",
"strongly",
"induced",
"in",
"late",
"gestation",
"in",
"uterine",
"/",
"placental",
"extracts",
"(iii)",
"NEAT1",
"induction",
"occurs",
"in",
"the",
"uterine",
"gland",
"nuclei",
"in",
"which",
"paraspeckles",
"were",
"detected.",
"Finally,",
"treatment",
"of",
"OK",
"cells",
"with",
"proteasome",
"inhibitors",
"induces",
"paraspeckle",
"assembly,",
"as",
"previously",
"observed",
"in",
"human",
"cells.",
"Altogether,",
"these",
"results",
"demonstrate",
"that",
"paraspeckles",
"are",
"tissue",
"-",
"specific,",
"stress",
"-responding",
"nuclear",
"bodies",
"in",
"marsupials,",
"illustrating",
"their",
"structural",
"and",
"functional",
"continuity",
"over",
"200",
"My",
"of",
"evolution",
"throughout",
"the",
"mammalian",
"lineage.",
"In",
"contrast,",
"the",
"rapid",
"evolution",
"of",
"the",
"NEAT1",
"transcripts",
"highlights",
"the",
"relaxed",
"constraint",
"that,",
"despite",
"functional",
"conservation,",
"is",
"exerted",
"on",
"this",
"lncRNA."
] | [
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[
"Ag",
"nanoclusters",
"could",
"efficiently",
"quench",
"the",
"photoresponse",
"of",
"CdS",
"quantum",
"dots",
"for",
"novel",
"energy",
"transfer",
"-based",
"photoelectrochemical",
"bioanalysis",
"Herein",
"the",
"influence",
"of",
"ultrasmall",
"Ag",
"nanoclusters",
"(Ag",
"NCs)",
"against",
"CdS",
"quantum",
"dots",
"(QDs)",
"in",
"a",
"photoelectrochemical",
"(PEC)",
"nanosystem",
"was",
"exploited",
"for",
"the",
"first",
"time,",
"based",
"on",
"which",
"a",
"novel",
"PEC",
"bioanalysis",
"was",
"successfully",
"developed",
"via",
"the",
"efficient",
"quenching",
"effect",
"of",
"Ag",
"NCs",
"against",
"the",
"CdS",
"QDs.",
"In",
"a",
"model",
"system,",
"DNA",
"assay",
"was",
"achieved",
"by",
"using",
"molecular",
"beacon",
"(MB)",
"probes",
"anchored",
"on",
"a",
"CdS",
"QDs",
"modified",
"electrode,",
"and",
"the",
"MB",
"probes",
"contain",
"two",
"segments",
"that",
"can",
"hybridize",
"with",
"both",
"target",
"DNA",
"sequence",
"and",
"the",
"label",
"of",
"DNA",
"encapsulated",
"Ag",
"NCs.",
"After",
"the",
"MB",
"probe",
"was",
"unfolded",
"by",
"the",
"target",
"DNA",
"sequence,",
"the",
"labels",
"of",
"oligonucleotide",
"encapsulated",
"Ag",
"NCs",
"would",
"be",
"brought",
"in",
"close",
"proximity",
"to",
"the",
"CdS",
"QDs",
"electrode",
"surface,",
"and",
"efficient",
"photocurrent",
"quenching",
"of",
"QDs",
"could",
"be",
"resulted",
"from",
"an",
"energy",
"transfer",
"process",
"that",
"originated",
"from",
"NCs.",
"Thus,",
"by",
"monitoring",
"the",
"attenuation",
"in",
"the",
"photocurrent",
"signal,",
"an",
"elegant",
"and",
"sensitive",
"PEC",
"DNA",
"bioanalysis",
"could",
"be",
"accomplished.",
"The",
"developed",
"biosensor",
"displayed",
"a",
"linear",
"range",
"from",
"1.0pM",
"to",
"10nM",
"and",
"the",
"detection",
"limit",
"was",
"experimentally",
"found",
"to",
"be",
"of",
"0.3pM.",
"This",
"work",
"presents",
"a",
"feasible",
"signaling",
"principle",
"that",
"could",
"act",
"as",
"a",
"common",
"basis",
"for",
"general",
"PEC",
"bioanalysis",
"development."
] | [
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[
"Does",
"obtaining",
"an",
"initial",
"magnetic",
"resonance",
"imaging",
"decrease",
"the",
"reamputation",
"rates",
"in",
"the",
"diabetic",
"foot?",
"Diabetes",
"mellitus",
"(DM)",
"through",
"its",
"over",
"glycosylation",
"of",
"neurovascular",
"structures",
"and",
"resultant",
"peripheral",
"neuropathy",
"continues",
"to",
"be",
"the",
"major",
"risk",
"factor",
"for",
"pedal",
"amputation.",
"Repetitive",
"trauma",
"to",
"the",
"insensate",
"foot",
"results",
"in",
"diabetic",
"foot",
"ulcers,",
"which",
"are",
"at",
"high",
"risk",
"to",
"develop",
"osteomyelitis.",
"Many",
"patients",
"who",
"present",
"with",
"diabetic",
"foot",
"complications",
"will",
"undergo",
"one",
"or",
"more",
"pedal",
"amputations",
"during",
"the",
"course",
"of",
"their",
"disease.",
"The",
"purpose",
"of",
"this",
"study",
"was",
"to",
"determine",
"if",
"obtaining",
"an",
"initial",
"magnetic",
"resonance",
"imaging",
"(MRI),",
"prior",
"to",
"the",
"first",
"amputation,",
"is",
"associated",
"with",
"a",
"decreased",
"rate",
"of",
"reamputation",
"in",
"the",
"diabetic",
"foot.",
"Our",
"hypothesis",
"was",
"that",
"the",
"rate",
"of",
"reamputation",
"may",
"be",
"associated",
"with",
"underutilization",
"of",
"obtaining",
"an",
"initial",
"MRI,",
"useful",
"in",
"presurgical",
"planning.",
"This",
"study",
"was",
"designed",
"to",
"determine",
"whether",
"there",
"was",
"an",
"association",
"between",
"the",
"reamputation",
"rate",
"in",
"diabetic",
"patients",
"and",
"utilization",
"of",
"MRI",
"in",
"the",
"presurgical",
"planning",
"and",
"prior",
"to",
"initial",
"forefoot",
"amputations.",
"Following",
"approval",
"by",
"our",
"institutional",
"review",
"board,",
"our",
"study",
"design",
"consisted",
"of",
"a",
"retrospective",
"cohort",
"analysis",
"of",
"413",
"patients",
"at",
"Staten",
"Island",
"University",
"Hospital,",
"a",
"700-bed",
"tertiary",
"referral",
"center",
"between",
"2008",
"and",
"2013",
"who",
"underwent",
"an",
"initial",
"great",
"toe",
"(hallux)",
"amputation.",
"Of",
"the",
"413",
"patients",
"with",
"a",
"hallux",
"amputation,",
"there",
"were",
"368",
"eligible",
"patients",
"who",
"had",
"a",
"history",
"of",
"DM",
"with",
"documented",
"hemoglobin",
"A1c",
"(HbA1c)",
"within",
"3",
"months",
"of",
"the",
"initial",
"first",
"ray",
"(hallux",
"and",
"first",
"metatarsal)",
"amputation",
"and",
"available",
"radiographic",
"data.",
"Statistical",
"analysis",
"compared",
"the",
"incidence",
"rates",
"of",
"reamputation",
"between",
"patients",
"who",
"underwent",
"initial",
"MRI",
"and",
"those",
"who",
"did",
"not",
"obtain",
"an",
"initial",
"MRI",
"prior",
"to",
"their",
"first",
"amputation.",
"The",
"reamputation",
"rate",
"was",
"compared",
"after",
"adjustment",
"for",
"age,",
"gender,",
"ethnicity,",
"HbA1c,",
"cardiovascular",
"disease,",
"hypoalbuminemia,",
"smoking,",
"body",
"mass",
"index,",
"and",
"prior",
"antibiotic",
"treatment.",
"The",
"results",
"of",
"our",
"statistical",
"analysis",
"failed",
"to",
"reveal",
"a",
"significant",
"association",
"between",
"obtaining",
"an",
"initial",
"MRI",
"and",
"the",
"reamputation",
"rate.",
"We",
"did,",
"however,",
"find",
"a",
"statistical",
"association",
"between",
"obtaining",
"an",
"early",
"MRI",
"and",
"decreased",
"mortality",
"rates.",
"Obtaining",
"an",
"early",
"MRI",
"was",
"not",
"associated",
"with",
"the",
"reamputation",
"rate",
"incidence",
"in",
"the",
"treatment",
"of",
"the",
"diabetic",
"foot.",
"It",
"did,",
"however,",
"have",
"a",
"statistically",
"significant",
"association",
"with",
"the",
"mortality",
"rate",
"as",
"demonstrated",
"by",
"the",
"increased",
"survival",
"rate",
"in",
"patients",
"undergoing",
"MRI",
"prior",
"to",
"initial",
"amputation."
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[
"Systematic",
"and",
"detailed",
"analysis",
"of",
"behavioural",
"tests",
"in",
"the",
"rat",
"middle",
"cerebral",
"artery",
"occlusion",
"model",
"of",
"stroke:",
"Tests",
"for",
"long-term",
"assessment",
"In",
"order",
"to",
"test",
"therapeutics,",
"functional",
"assessments",
"are",
"required.",
"In",
"pre-clinical",
"stroke",
"research,",
"there",
"is",
"little",
"consensus",
"regarding",
"the",
"most",
"appropriate",
"behavioural",
"tasks",
"to",
"assess",
"deficits,",
"especially",
"when",
"testing",
"over",
"extended",
"times",
"in",
"milder",
"models",
"with",
"short",
"occlusion",
"times",
"and",
"small",
"lesion",
"volumes.",
"In",
"this",
"study,",
"we",
"comprehensively",
"assessed",
"16",
"different",
"behavioural",
"tests,",
"with",
"the",
"aim",
"of",
"identifying",
"those",
"that",
"show",
"robust,",
"reliable",
"and",
"stable",
"deficits",
"for",
"up",
"to",
"two",
"months.",
"These",
"tasks",
"are",
"regularly",
"used",
"in",
"stroke",
"research,",
"as",
"well",
"as",
"being",
"useful",
"for",
"examining",
"striatal",
"dysfunction",
"in",
"models",
"of",
"Huntington's",
"and",
"Parkinson's",
"disease.",
"Two",
"cohorts",
"of",
"male",
"Wistar",
"rats",
"underwent",
"the",
"intraluminal",
"filament",
"model",
"of",
"middle",
"cerebral",
"artery",
"occlusion",
"(30",
"min)",
"and",
"were",
"imaged",
"24",
"h",
"later.",
"This",
"resulted",
"in",
"primarily",
"subcortical",
"infarcts,",
"with",
"a",
"small",
"amount",
"of",
"cortical",
"damage.",
"Animals",
"were",
"tested,",
"along",
"with",
"sham",
"and",
"naïve",
"groups",
"at",
"24",
"h,",
"seven",
"days,",
"and",
"one",
"and",
"two",
"months.",
"Following",
"behavioural",
"testing,",
"brains",
"were",
"processed",
"and",
"striatal",
"neuronal",
"counts",
"were",
"performed",
"alongside",
"measurements",
"of",
"total",
"brain",
"and",
"white",
"matter",
"atrophy.",
"The",
"staircase,",
"adjusting",
"steps,",
"rotarod",
"and",
"apomorphine",
"-induced",
"rotations",
"were",
"the",
"most",
"reliable",
"for",
"assessing",
"long-term",
"deficits",
"in",
"the",
"30",
"min",
"transient",
"middle",
"cerebral",
"artery",
"occlusion",
"model",
"of",
"stroke."
] | [
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[
"The",
"next",
"frontier",
"of",
"office",
"-based",
"inferior",
"vena",
"cava",
"filter",
"placement",
"There",
"is",
"an",
"increasing",
"number",
"of",
"procedures",
"that",
"traditionally",
"were",
"performed",
"in",
"the",
"inpatient",
"setting",
"that",
"are",
"now",
"becoming",
"office",
"-based",
"procedures.",
"These",
"include",
"peripheral",
"endovascular",
"procedures",
"such",
"as",
"angiograms,",
"angioplasties,",
"dialysis",
"access",
"interventions,",
"and",
"treatment",
"for",
"venous",
"insufficiency.",
"We",
"chose",
"to",
"evaluate",
"the",
"feasibility,",
"safety",
"of",
"inferior",
"vena",
"cava",
"(IVC)",
"filter",
"placement",
"in",
"the",
"office-based",
"setting.",
"All",
"procedures",
"were",
"performed",
"using",
"local",
"anesthesia,",
"and",
"ultrasound",
"guidance",
"for",
"puncture.",
"All",
"venograms",
"were",
"performed",
"with",
"manual",
"injection",
"of",
"iodinated",
"contrast.",
"An",
"IVC",
"filter",
"was",
"placed",
"in",
"the",
"cases",
"(except",
"one",
"failure",
"of",
"placement)",
"using",
"fluoroscopy",
"in",
"the",
"infrarenal",
"position.",
"Patients",
"were",
"observed",
"in",
"a",
"recovery",
"area",
"and",
"then",
"discharged.",
"Follow-up",
"data",
"were",
"obtained",
"through",
"an",
"interview,",
"physical",
"examination,",
"and",
"24-hour",
"postoperative",
"phone",
"call.",
"Over",
"the",
"course",
"of",
"27",
"months,",
"29",
"Greenfield",
"filters",
"(Boston",
"Scientific,",
"Marlborough,",
"Mass)",
"and",
"three",
"Celect",
"temporary",
"filters",
"(Cook,",
"Bloomington,",
"Ind)",
"were",
"placed",
"in",
"the",
"infrarenal",
"IVC",
"for",
"18",
"women",
"and",
"14",
"men,",
"with",
"an",
"average",
"age",
"of",
"75.3",
"±",
"15.6",
"years",
"(range,",
"38-97",
"years).",
"Twenty-four",
"acute,",
"6",
"recent",
"(<6",
"months",
"ago)",
"and",
"three",
"subacute",
"lower",
"extremity",
"deep",
"vein",
"thromboses",
"(DVTs)",
"were",
"identified.",
"The",
"indications",
"for",
"the",
"procedure",
"were",
"patients",
"with:",
"DVT",
"who",
"were",
"to",
"undergo",
"surgery",
"(n",
"=",
"6),",
"acute",
"large",
"free-floating",
"iliofemoral",
"DVT",
"(deemed",
"high-risk",
"for",
"long-term",
"anticoagulation)",
"(n",
"=",
"7),",
"new",
"DVT",
"during",
"anticoagulation",
"therapy",
"(n",
"=",
"6),",
"DVT",
"with",
"gastrointestinal",
"bleeding",
"(n",
"=",
"4),",
"DVT",
"with",
"hematuria",
"(n",
"=",
"2),",
"recent",
"DVT",
"(which",
"extended",
"during",
"full",
"dose",
"anticoagulation",
"treatment)",
"while",
"undergoing",
"a",
"long",
"flight",
"(n",
"=",
"1)",
"(temporary",
"filter",
"placement),",
"DVT",
"with",
"arm",
"hematoma",
"(n",
"=",
"1),",
"DVT",
"with",
"unsteady",
"gait",
"and",
"history",
"of",
"falls",
"(n",
"=",
"2),",
"DVT",
"with",
"nose",
"bleeding",
"(n",
"=",
"1),",
"DVT",
"with",
"dementia",
"and",
"inability",
"to",
"receive",
"anticoagulation",
"treatment",
"(n",
"=",
"1),",
"DVT",
"and",
"receiving",
"chemotherapy",
"and",
"with",
"thrombocytopenia",
"(n",
"=",
"1),",
"and",
"DVT",
"and",
"refusal",
"to",
"take",
"anticoagulation",
"medication",
"(n",
"=",
"1).",
"One",
"patient",
"had",
"a",
"failure",
"to",
"place",
"a",
"filter",
"because",
"of",
"chronic",
"IVC",
"occlusion",
"found",
"on",
"venogram.",
"One",
"patient",
"with",
"history",
"of",
"gastrointestinal",
"bleeding,",
"acute",
"DVT,",
"and",
"atrial",
"fibrillation",
"suffered",
"IVC",
"filter",
"thrombosis",
"1",
"month",
"after",
"the",
"procedure.",
"We",
"attempted",
"removal",
"of",
"the",
"temporary",
"filters",
"in",
"the",
"hospital",
"in",
"two",
"patients",
"but",
"failed",
"to",
"retrieve",
"the",
"filter",
"in",
"these",
"two",
"cases.",
"We",
"noted",
"no",
"insertion",
"site",
"DVT,",
"extension",
"of",
"DVT,",
"or",
"pulmonary",
"embolism.",
"Our",
"preliminary",
"experience",
"suggests",
"that",
"placement",
"of",
"IVC",
"filters",
"for",
"treatment",
"of",
"venous",
"thrombotic",
"events",
"in",
"an",
"office-based",
"facility",
"is",
"safe",
"and",
"efficacious",
"with",
"basic",
"endovascular",
"equipment.",
"Long-term",
"outcome",
"cannot",
"be",
"determined",
"at",
"this",
"point."
] | [
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[
"Insensitivity",
"of",
"astrocytes",
"to",
"interleukin",
"10",
"signaling",
"following",
"peripheral",
"immune",
"challenge",
"results",
"in",
"prolonged",
"microglial",
"activation",
"in",
"the",
"aged",
"brain",
"Immune-activated",
"microglia",
"from",
"aged",
"mice",
"produce",
"exaggerated",
"levels",
"of",
"cytokines.",
"Despite",
"high",
"levels",
"of",
"microglia",
"l",
"interleukin",
"(IL)-10",
"in",
"the",
"aged",
"brain,",
"neuroinflammation",
"was",
"prolonged",
"and",
"associated",
"with",
"depressive-like",
"deficits.",
"Because",
"astrocytes",
"respond",
"to",
"IL-10",
"and,",
"in",
"turn,",
"attenuate",
"microglial",
"activation,",
"we",
"investigated",
"if",
"astrocyte-mediated",
"resolution",
"of",
"microglial",
"activation",
"was",
"impaired",
"with",
"age.",
"Here,",
"aged",
"astrocytes",
"had",
"a",
"dysfunctional",
"profile",
"with",
"higher",
"glial",
"fibrillary",
"acidic",
"protein,",
"lower",
"glutamate",
"transporter",
"expression,",
"and",
"significant",
"cytoskeletal",
"re-arrangement.",
"Moreover,",
"aged",
"astrocytes",
"had",
"reduced",
"expression",
"of",
"growth",
"factors",
"and",
"IL-10",
"receptor-1",
"(IL-10R1).",
"After",
"in",
"vivo",
"lipopolysaccharide",
"immune",
"challenge,",
"aged",
"astrocytes",
"had",
"a",
"molecular",
"signature",
"associated",
"with",
"reduced",
"responsiveness",
"to",
"IL-10.",
"This",
"IL-10",
"insensitivity",
"of",
"aged",
"astrocytes",
"resulted",
"in",
"a",
"failure",
"to",
"induce",
"IL-10R1",
"and",
"transforming",
"growth",
"factor",
"β",
"and",
"resolve",
"microglial",
"activation.",
"In",
"addition,",
"adult",
"astrocytes",
"reduced",
"microglial",
"activation",
"when",
"co-cultured",
"ex",
"vivo,",
"whereas",
"aged",
"astrocytes",
"did",
"not.",
"Consistent",
"with",
"the",
"aging",
"studies,",
"IL-10R(KO)",
"astrocytes",
"did",
"not",
"augment",
"transforming",
"growth",
"factor",
"β",
"after",
"immune",
"challenge",
"and",
"failed",
"to",
"resolve",
"microglial",
"activation.",
"Collectively,",
"a",
"major",
"cytokine",
"-",
"regulatory",
"loop",
"between",
"activated",
"microglia",
"and",
"astrocytes",
"is",
"impaired",
"in",
"the",
"aged",
"brain."
] | [
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[
"Percutaneous",
"Bullectomy",
"in",
"Conjunction",
"with",
"Endobronchial",
"Valve",
"Placement",
"as",
"an",
"Alternative",
"to",
"Surgical",
"Management",
"of",
"Giant",
"Bullae",
"We",
"present",
"the",
"first",
"reported",
"case",
"of",
"the",
"treatment",
"and",
"management",
"of",
"a",
"giant",
"bulla",
"using",
"percutaneous",
"bullectomy",
"and",
"endobronchial",
"valve",
"placement.",
"A",
"74-",
"year",
"-old",
"woman",
"with",
"chronic",
"obstructive",
"pulmonary",
"disease",
"and",
"a",
"known",
"large",
"bulla",
"in",
"the",
"left",
"chest",
"presented",
"to",
"the",
"emergency",
"department",
"with",
"acute-onset",
"confusion",
"after",
"a",
"traumatic",
"fall.",
"She",
"was",
"subsequently",
"diagnosed",
"with",
"an",
"intracranial",
"hemorrhage",
"in",
"the",
"distribution",
"of",
"the",
"right",
"basal",
"ganglia.",
"Chest",
"imaging",
"revealed",
"a",
"giant",
"apical",
"bulla",
"occupying",
"80%",
"of",
"the",
"left",
"hemithorax.",
"In",
"addition,",
"there",
"was",
"midline",
"shift",
"away",
"from",
"the",
"affected",
"side",
"associated",
"with",
"volume",
"loss",
"in",
"the",
"right",
"hemithorax",
"and",
"no",
"radiographic",
"evidence",
"of",
"aeration",
"in",
"the",
"remainder",
"of",
"the",
"left",
"lung.",
"Arterial",
"blood",
"gas",
"analysis",
"revealed",
"significant",
"hypercapnia.",
"Surgical",
"bullectomy",
"was",
"not",
"an",
"option,",
"and",
"thus,",
"a",
"novel",
"approach",
"was",
"utilized",
"to",
"treat",
"this",
"patient."
] | [
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1,
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1,
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] |
[
"Constitutive",
"expression",
"of",
"cytochrome",
"P450",
"in",
"foetal",
"and",
"adult",
"porcine",
"livers",
"-",
"Effects",
"of",
"body",
"weight",
"The",
"liver",
"hosts",
"a",
"great",
"number",
"of",
"enzymatically",
"driven",
"processes,",
"including",
"detoxification.",
"The",
"super-family",
"of",
"enzymes",
"named",
"cytochrome",
"P450",
"(CYP)",
"is",
"the",
"major",
"participant",
"in",
"that",
"process.",
"The",
"expression",
"of",
"CYPs",
"is",
"affected",
"by",
"several",
"factors",
"including",
"life-stage",
"(foetal",
"vs.",
"adult).",
"In",
"the",
"present",
"study",
"we",
"investigated",
"the",
"impact",
"of",
"birth-weight",
"(high",
"or",
"low",
"birth",
"weight)",
"and",
"life-stage",
"on",
"constitutive",
"expression",
"of",
"porcine",
"hepatic",
"CYP1A1,",
"CYP1A2,",
"CYP2A19,",
"CYP2B22,",
"CYP2C33,",
"CYP2D25,",
"CYP2E1",
"and",
"CYP3A29,",
"as",
"well",
"as",
"the",
"transcription",
"factors",
"controlling",
"their",
"expression;",
"aryl",
"hydrocarbon",
"receptor,",
"constitutive",
"androstane",
"receptor,",
"pregnane",
"X",
"receptor,",
"C/EBP",
"and",
"hepatocyte",
"nuclear",
"factors",
"1",
"and",
"4.",
"Both",
"RT-PCR",
"and",
"western",
"blotting",
"showed",
"a",
"marked",
"increase",
"in",
"the",
"expression",
"of",
"the",
"adult",
"pigs",
"compared",
"with",
"prenatal",
"pigs.",
"Moreover,",
"CYP2E1",
"mRNA",
"expression",
"was",
"7.5",
"fold",
"higher",
"in",
"foetuses",
"with",
"low",
"birth",
"weight",
"compared",
"with",
"foetuses",
"with",
"high",
"birth",
"weight.",
"Gender",
"did",
"not",
"affect",
"the",
"mRNA",
"expression",
"within",
"the",
"different",
"life-stages.",
"These",
"results",
"indicate",
"a",
"similarity",
"to",
"what",
"is",
"observed",
"in",
"humans",
"and",
"porcine",
"foetuses",
"may",
"therefore",
"be",
"a",
"model",
"for",
"humans",
"when",
"studying",
"expression",
"of",
"CYPs."
] | [
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1,
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] |
[
"Antipsychotic",
"Drugs",
"and",
"Risk",
"of",
"Hip",
"Fracture",
"in",
"People",
"Aged",
"60",
"and",
"Older",
"in",
"Norway",
"To",
"examine",
"associations",
"between",
"exposure",
"to",
"various",
"subgroups",
"of",
"antipsychotic",
"drugs",
"and",
"risk",
"of",
"hip",
"fracture",
"in",
"older",
"adults.",
"Nationwide",
"cohort",
"study.",
"Norway,",
"2005-2010.",
"Everyone",
"living",
"in",
"Norway",
"born",
"before",
"1945",
"(N",
"=",
"906,422).",
"Information",
"was",
"obtained",
"on",
"all",
"prescriptions",
"of",
"antipsychotic",
"drugs",
"dispensed",
"from",
"2004",
"to",
"2010",
"(Norwegian",
"Prescription",
"Database)",
"and",
"data",
"on",
"all",
"primary",
"hip",
"fractures",
"from",
"2005",
"to",
"2010",
"(Norwegian",
"Hip",
"Fracture",
"Registry).",
"Incidence",
"rates",
"of",
"hip",
"fracture",
"during",
"person-time",
"exposed",
"and",
"unexposed",
"to",
"antipsychotic",
"drugs",
"were",
"compared",
"by",
"calculating",
"the",
"standardized",
"incidence",
"ratio",
"(SIR).",
"Thirty-nine",
"thousand",
"nine",
"hundred",
"thirty-eight",
"(4.4%)",
"participants",
"experienced",
"a",
"primary",
"hip",
"fracture.",
"Greater",
"risk",
"of",
"hip",
"fracture",
"was",
"associated",
"with",
"exposure",
"to",
"any",
"antipsychotic",
"(SIR",
"=",
"2.1,",
"95%",
"confidence",
"interval",
"(CI)",
"=",
"1.9-2.1),",
"first-generation",
"antipsychotics",
"(SIR",
"=",
"2.0,",
"95%",
"CI",
"=",
"1.8-2.2),",
"second-generation",
"antipsychotics",
"(SIR",
"=",
"2.2,",
"95%",
"CI",
"=",
"1.9-2.4),",
"prolactin",
"-sparing",
"antipsychotics",
"(SIR",
"=",
"2.4,",
"95%",
"CI",
"=",
"1.8-3.1)",
"and",
"prolactin",
"-elevating",
"antipsychotics",
"(SIR",
"=",
"2.0,",
"95%",
"CI",
"=",
"1.9-2.2).",
"In",
"people",
"aged",
"60",
"and",
"older",
"in",
"Norway,",
"those",
"who",
"took",
"an",
"antipsychotic",
"drug",
"had",
"twice",
"the",
"risk",
"of",
"sustaining",
"a",
"hip",
"fracture",
"during",
"exposure",
"than",
"during",
"nonexposure.",
"Although",
"confounding",
"by",
"indication,",
"comorbidity,",
"or",
"other",
"drugs",
"used",
"cannot",
"be",
"excluded,",
"this",
"association",
"is",
"relevant",
"for",
"clinical",
"practice",
"because",
"hip",
"fracture",
"and",
"antipsychotic",
"drug",
"use",
"are",
"prevalent",
"in",
"vulnerable",
"older",
"individuals.",
"Clinical",
"studies",
"examining",
"mechanisms",
"or",
"causality",
"of",
"the",
"observed",
"association",
"between",
"antipsychotic",
"drug",
"use",
"and",
"excess",
"risk",
"of",
"hip",
"fracture",
"are",
"needed."
] | [
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2,
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1,
2,
1,
2,
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0
] |
[
"Bisphenol-A",
"removal",
"by",
"the",
"halophyte",
"Juncus",
"acutus",
"in",
"a",
"phytoremediation",
"pilot:",
"Characterization",
"and",
"potential",
"role",
"of",
"the",
"endophytic",
"community",
"A",
"phytoremediation",
"pilot",
"emulating",
"a",
"shallow",
"aquifer",
"planted",
"with",
"Juncus",
"acutus",
"showed",
"to",
"be",
"effective",
"for",
"remediating",
"Bisphenol-A",
"(BPA)",
"contaminated",
"groundwater.",
"Biostimulation",
"with",
"root",
"exudates,",
"low",
"molecular",
"weight",
"organic",
"acids,",
"of",
"J.",
"acutus",
"did",
"not",
"improve",
"BPA",
"-",
"degradation",
"rates.",
"Furthermore,",
"the",
"endophytic",
"bacterial",
"community",
"of",
"J.",
"acutus",
"was",
"isolated",
"and",
"characterized.",
"Many",
"strains",
"were",
"found",
"to",
"possess",
"increased",
"tolerance",
"to",
"metals",
"such",
"as",
"Zn,",
"Ni,",
"Pb",
"and",
"Cd.",
"Moreover,",
"several",
"endophytic",
"bacterial",
"strains",
"tolerated",
"and",
"even",
"used",
"BPA",
"and/or",
"two",
"antibiotics",
"(ciprofloxacin",
"and",
"sulfamethoxazole)",
"as",
"a",
"sole",
"carbon",
"source.",
"Our",
"results",
"demonstrate",
"that",
"the",
"cultivable",
"bacterial",
"endophytic",
"community",
"of",
"J.",
"acutus",
"is",
"able",
"to",
"use",
"organic",
"contaminants",
"as",
"carbon",
"sources,",
"tolerates",
"metals",
"and",
"is",
"equipped",
"with",
"plant-growth",
"promoting",
"traits.",
"Therefore,",
"J.",
"acutus",
"has",
"potential",
"to",
"be",
"exploited",
"in",
"constructed",
"wetlands",
"when",
"co-contamination",
"is",
"one",
"of",
"the",
"restricting",
"factors."
] | [
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[
"Structure",
"of",
"Carbon",
"Nanotube",
"Porins",
"in",
"Lipid",
"Bilayers:",
"An",
"in",
"Situ",
"Small-Angle",
"X-ray",
"Scattering",
"(SAXS)",
"Study",
"Carbon",
"nanotube",
"porins",
"(CNTPs),",
"small",
"segments",
"of",
"carbon",
"nanotubes",
"capable",
"of",
"forming",
"defined",
"pores",
"in",
"lipid",
"membranes,",
"are",
"important",
"future",
"components",
"for",
"bionanoelectronic",
"devices",
"as",
"they",
"could",
"provide",
"a",
"robust",
"analog",
"of",
"biological",
"membrane",
"channels.",
"In",
"order",
"to",
"control",
"the",
"incorporation",
"of",
"these",
"CNT",
"channels",
"into",
"lipid",
"bilayers,",
"it",
"is",
"important",
"to",
"understand",
"the",
"structure",
"of",
"the",
"CNTPs",
"before",
"and",
"after",
"insertion",
"into",
"the",
"lipid",
"bilayer",
"as",
"well",
"as",
"the",
"impact",
"of",
"such",
"insertion",
"on",
"the",
"bilayer",
"structure.",
"Here",
"we",
"employed",
"a",
"noninvasive",
"in",
"situ",
"probe,",
"small-angle",
"X-ray",
"scattering,",
"to",
"study",
"the",
"integration",
"of",
"CNT",
"porins",
"into",
"dioleoylphosphatidylcholine",
"bilayers.",
"Our",
"results",
"show",
"that",
"CNTPs",
"in",
"solution",
"are",
"stabilized",
"by",
"a",
"monolayer",
"of",
"lipid",
"molecules",
"wrapped",
"around",
"their",
"outer",
"surface.",
"We",
"also",
"demonstrate",
"that",
"insertion",
"of",
"CNTPs",
"into",
"the",
"lipid",
"bilayer",
"results",
"in",
"decreased",
"bilayer",
"thickness",
"with",
"the",
"magnitude",
"of",
"this",
"effect",
"increasing",
"with",
"the",
"concentration",
"of",
"CNTPs."
] | [
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[
"The",
"anti-apoptotic",
"PON2",
"protein",
"is",
"Wnt",
"/",
"β-catenin",
"-",
"regulated",
"and",
"correlates",
"with",
"radiotherapy",
"resistance",
"in",
"OSCC",
"patients",
"Aberrant",
"Wnt",
"signaling",
"and",
"control",
"of",
"anti-apoptotic",
"mechanisms",
"are",
"pivotal",
"features",
"in",
"different",
"types",
"of",
"cancer",
"to",
"undergo",
"cell",
"death",
"programs.",
"The",
"intracellular",
"human",
"enzyme",
"Paraoxonase-2",
"(PON2)",
"is",
"known",
"to",
"have",
"anti-apoptotic",
"properties",
"in",
"leukemia",
"and",
"oral",
"squamous",
"cell",
"cancer",
"(OSCC)",
"cells.",
"However,",
"the",
"distinct",
"regulating",
"pathways",
"are",
"poorly",
"understood.",
"First,",
"we",
"present",
"a",
"so",
"far",
"unknown",
"regulation",
"of",
"PON2",
"protein",
"expression",
"through",
"the",
"Wnt",
"/",
"GSK3β",
"/",
"β-catenin",
"pathway",
"in",
"leukemia",
"and",
"OSCC",
"cells.",
"This",
"was",
"confirmed",
"via",
"in",
"silico",
"analysis,",
"promoter",
"reporter",
"studies",
"and",
"treatment",
"of",
"multiple",
"cell",
"lines",
"(K562,",
"SCC-4,",
"PCI-13)",
"with",
"different",
"Wnt",
"ligands",
"/",
"inhibitors",
"in",
"vitro.",
"Ex",
"vivo",
"analysis",
"of",
"OSCC",
"patients",
"revealed",
"a",
"correlation",
"between",
"PON2",
"and",
"β-catenin",
"expression",
"in",
"tumor",
"tissue.",
"Higher",
"PON2",
"expression",
"in",
"OSCC",
"is",
"associated",
"with",
"relapse",
"independently",
"of",
"treatment",
"(e.g.",
"surgery",
"/",
"radio",
"-/",
"chemotherapy).",
"These",
"results",
"emphasize",
"the",
"clinical",
"impact",
"of",
"the",
"newly",
"described",
"regulation",
"of",
"PON2",
"through",
"Wnt",
"/",
"GSK3β",
"/",
"β-catenin.",
"More",
"importantly,",
"the",
"study",
"revealed",
"the",
"fundamental",
"finding",
"of",
"an",
"overall",
"Wnt",
"/",
"GSK3β",
"/",
"β-catenin",
"dependent",
"regulation",
"of",
"PON2",
"in",
"different",
"cancers,",
"which",
"was",
"confirmed",
"by",
"systematic",
"and",
"multimethodological",
"approaches.",
"Thus,",
"the",
"herein",
"presented",
"mechanistic",
"insight",
"contributes",
"to",
"a",
"better",
"understanding",
"of",
"tumor",
"specific",
"escape",
"from",
"cell",
"death",
"strategies",
"and",
"suggests",
"PON2",
"as",
"a",
"new",
"potential",
"biomarker",
"for",
"therapy",
"resistance",
"or",
"as",
"a",
"prognostic",
"tumor",
"marker."
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[
"Has",
"dementia",
"research",
"lost",
"its",
"sense",
"of",
"reality?",
"A",
"descriptive",
"analysis",
"of",
"eligibility",
"criteria",
"of",
"Dutch",
"dementia",
"research",
"protocols",
"A",
"substantial",
"proportion",
"of",
"dementia",
"patients",
"are",
"excluded",
"from",
"research",
"participation,",
"while",
"for",
"extrapolation",
"of",
"the",
"study",
"findings,",
"it",
"is",
"important",
"that",
"the",
"research",
"population",
"represents",
"the",
"patient",
"population.",
"The",
"aim",
"of",
"this",
"study",
"is",
"to",
"provide",
"an",
"analysis",
"of",
"dementia",
"research",
"and",
"its",
"exclusion",
"criteria",
"in",
"order",
"to",
"get",
"a",
"clearer",
"picture",
"whether",
"the",
"research",
"participants",
"represent",
"the",
"general",
"dementia",
"population.",
"Dementia",
"studies",
"registered",
"at",
"ToetsingOnline.nl",
"between",
"2006-2015",
"were",
"analysed.",
"Study",
"characteristics,",
"funding",
"and",
"eligibility",
"criteria",
"were",
"described",
"and",
"analysed",
"using",
"a",
"standardised",
"score",
"sheet.",
"The",
"search",
"yielded",
"103",
"usable",
"study",
"protocols.",
"The",
"number",
"of",
"trials",
"has",
"increased",
"over",
"the",
"years,",
"and",
"35%",
"of",
"the",
"studies",
"were",
"industry",
"-",
"financed.",
"Alzheimer's",
"disease",
"was",
"the",
"most",
"researched",
"type",
"of",
"dementia",
"(84%).",
"In",
"observational",
"studies",
"the",
"most",
"frequently",
"observed",
"exclusion",
"criterion",
"is",
"a",
"neurological",
"condition,",
"while",
"in",
"drug",
"studies",
"and",
"other",
"intervention",
"studies",
"this",
"is",
"a",
"somatic",
"condition.",
"Of",
"all",
"protocols,",
"86%",
"had",
"at",
"least",
"one",
"exclusion",
"criterion",
"concerning",
"comorbidity.",
"Most",
"studies",
"focused",
"on",
"mild",
"or",
"moderate",
"dementia",
"(78%).",
"Our",
"study",
"has",
"shown",
"that",
"the",
"distribution",
"of",
"dementia",
"research",
"over",
"the",
"different",
"subtypes",
"of",
"dementia",
"does",
"not",
"correspond",
"with",
"the",
"prevalence",
"of",
"these",
"subtypes",
"in",
"clinical",
"practice.",
"The",
"research",
"population",
"in",
"the",
"protocols",
"is",
"not",
"representative",
"of",
"the",
"larger",
"patient",
"population.",
"A",
"greater",
"number",
"of",
"dementia",
"patients",
"could",
"derive",
"benefit",
"from",
"the",
"conducted",
"research",
"if",
"the",
"research",
"agenda",
"were",
"more",
"closely",
"aligned",
"with",
"disease",
"prevalence.",
"A",
"better",
"representation",
"of",
"all",
"dementia",
"patients",
"in",
"research",
"will",
"help",
"to",
"meet",
"the",
"needs",
"of",
"these",
"patients."
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[
"Tissue",
"-selective",
"inflammation",
"in",
"the",
"oral",
"cavity",
"of",
"the",
"rat",
"In",
"the",
"current",
"study,",
"carrageenan",
"(CG;",
"100-1000",
"μg/site)",
"was",
"injected",
"intraorally",
"in",
"the",
"cheeks",
"of",
"Holtzman",
"or",
"Wistar",
"rats",
"to",
"evaluate",
"the",
"consequences",
"of",
"administration",
"of",
"a",
"non-immunogenic",
"stimulus",
"in",
"the",
"orofacial",
"region.",
"Subsequent",
"inflammation",
"was",
"measured",
"as",
"oedema",
"(increased",
"thickness",
"of",
"the",
"cheek",
"wall",
"using",
"digital",
"calipers),",
"relative",
"to",
"the",
"other",
"cheek",
"injected",
"with",
"saline.",
"Oedema",
"formation",
"and",
"tissue",
"collection",
"for",
"histopathological",
"studies",
"were",
"assessed",
"at",
"0.5,",
"1,",
"2,",
"3,",
"4,",
"6,",
"24,",
"48,",
"72,",
"96,",
"120",
"and",
"144",
"h",
"after",
"injection.",
"In",
"parallel,",
"other",
"groups",
"of",
"rats",
"were",
"injected",
"with",
"CG",
"in",
"the",
"hind",
"paw,",
"to",
"provide",
"a",
"reference",
"response.",
"The",
"inhibitor",
"of",
"prostaglandin",
"biosynthesis,",
"indomethacin,",
"and",
"antagonists",
"of",
"histamine,",
"serotonin",
"and",
"NK1",
"receptors",
"were",
"injected",
"s.c.,",
"0.5",
"h",
"before",
"CG.",
"CG",
"induced",
"a",
"dose",
"-related",
"oedema",
"more",
"rapidly",
"from",
"0",
"to",
"2",
"h",
"which",
"lasted",
"for",
"at",
"least",
"72",
"h,",
"showing",
"a",
"biphasic",
"profile",
"(peak",
"at",
"2",
"and",
"24",
"h),",
"compared",
"with",
"the",
"monophasic",
"oedema",
"induced",
"in",
"rat",
"paws",
"(maximal",
"duration",
"of",
"24",
"h).",
"Histopathological",
"analysis",
"of",
"the",
"CG",
"-",
"injected",
"cheek",
"revealed",
"oedema",
"formation",
"with",
"little",
"leukocyte",
"recruitment",
"at",
"1-3",
"h,",
"mast",
"cell",
"degranulation",
"at",
"6",
"h,",
"and",
"a",
"mixed",
"polymorphonuclear",
"and",
"mononuclear",
"cell",
"infiltrate",
"by",
"24",
"h.",
"Histamine",
"and",
"serotonin",
"antagonists",
"and",
"indomethacin,",
"but",
"not",
"the",
"NK1",
"antagonist,",
"decreased",
"cheek",
"oedema",
"in",
"the",
"first",
"4",
"h",
"following",
"carrageenan.",
"Taken",
"together,",
"our",
"data",
"indicated",
"important",
"differences",
"in",
"the",
"pattern",
"of",
"inflammation",
"between",
"the",
"oral",
"cavity",
"and",
"the",
"paw",
"which",
"will",
"determine",
"the",
"therapeutic",
"approach",
"to",
"the",
"treatment",
"of",
"inflammatory",
"conditions",
"in",
"the",
"oral",
"cavity."
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[
"Mercury",
"Mining",
"in",
"Mexico:",
"I.",
"Community",
"Engagement",
"to",
"Improve",
"Health",
"Outcomes",
"from",
"Artisanal",
"Mining",
"Mercury",
"is",
"an",
"element",
"that",
"cannot",
"be",
"destroyed",
"and",
"is",
"a",
"global",
"threat",
"to",
"human",
"and",
"environmental",
"health.",
"In",
"Latin",
"America",
"and",
"the",
"Caribbean,",
"artisanal",
"and",
"small-scale",
"gold",
"mining",
"represents",
"the",
"main",
"source",
"of",
"mercury",
"emissions,",
"releases,",
"and",
"consumption.",
"However,",
"another",
"source",
"of",
"concern",
"is",
"the",
"primary",
"production",
"of",
"mercury.",
"In",
"the",
"case",
"of",
"Mexico,",
"in",
"the",
"past",
"2",
"years",
"the",
"informal",
"production",
"of",
"mercury",
"mining",
"has",
"increased",
"10-fold.",
"Considering",
"this",
"scenario,",
"an",
"intervention",
"program",
"was",
"initiated",
"to",
"reduce",
"health",
"risks",
"in",
"the",
"mining",
"communities.",
"The",
"program's",
"final",
"goal",
"is",
"to",
"introduce",
"different",
"alternatives",
"in",
"line",
"to",
"stop",
"the",
"mining",
"of",
"mercury,",
"but",
"introducing",
"at",
"the",
"same",
"time,",
"a",
"community",
"-based",
"development",
"program.",
"The",
"aim",
"of",
"this",
"study",
"was",
"to",
"present",
"results",
"from",
"a",
"preliminary",
"study",
"in",
"the",
"community",
"of",
"Plazuela,",
"located",
"in",
"the",
"municipality",
"of",
"Peñamiller",
"in",
"the",
"State",
"of",
"Queretaro,",
"Mexico.",
"Total",
"mercury",
"was",
"measured",
"in",
"urine",
"and",
"environmental",
"samples",
"using",
"atomic",
"absorption",
"spectrometry",
"by",
"cold",
"vapor",
"technique.",
"Urine",
"samples",
"were",
"collected",
"from",
"children",
"aged",
"6-14",
"years",
"and",
"who",
"had",
"lived",
"in",
"the",
"selected",
"area",
"from",
"birth.",
"Urine",
"samples",
"were",
"also",
"collected",
"from",
"miners",
"who",
"were",
"currently",
"working",
"in",
"the",
"mine.",
"To",
"confirm",
"the",
"presence",
"of",
"mercury",
"in",
"the",
"community,",
"mining",
"waste,",
"water,",
"soil,",
"and",
"sediment",
"samples",
"were",
"collected",
"from",
"those",
"high-risk",
"areas",
"identified",
"by",
"members",
"of",
"the",
"community.",
"Children,",
"women,",
"and",
"miners",
"were",
"heavily",
"exposed",
"to",
"mercury",
"(urine",
"samples);",
"and",
"in",
"agreement,",
"we",
"registered",
"high",
"concentrations",
"of",
"mercury",
"in",
"soils",
"and",
"sediments.",
"Considering",
"these",
"results",
"and",
"taking",
"into",
"account",
"that",
"the",
"risk",
"perception",
"toward",
"mercury",
"toxicity",
"is",
"very",
"low",
"in",
"the",
"community",
"(mining",
"is",
"the",
"only",
"economic",
"activity),",
"an",
"integral",
"intervention",
"program",
"has",
"started."
] | [
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[
"Anomalous",
"Left",
"Anterior",
"Descending",
"Coronary",
"Artery",
"Arising",
"from",
"Pulmonary",
"Artery",
"in",
"a",
"63",
"Year-old",
"Male",
"Patient:",
"Case",
"Report",
"and",
"Literature",
"Review",
"To",
"present",
"a",
"case",
"of",
"a",
"rare",
"congenital",
"coronary",
"anomaly",
"in",
"an",
"adult",
"patient,",
"which",
"was",
"not",
"reported",
"before",
"in",
"Palestine,",
"review",
"the",
"literature,",
"and",
"compare",
"with",
"previously",
"reported",
"cases."
] | [
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[
"Prevalence",
"of",
"Coronary",
"Artery",
"to",
"Pulmonary",
"Artery",
"Collaterals",
"in",
"Patients",
"with",
"Chronic",
"Thromboembolic",
"Pulmonary",
"Hypertension:",
"Retrospective",
"Analysis",
"from",
"a",
"Single",
"Center",
"Background",
"Our",
"aim",
"was",
"to",
"determine",
"the",
"prevalence",
"of",
"coronary",
"artery",
"-",
"pulmonary",
"artery",
"collaterals",
"in",
"patients",
"with",
"chronic",
"thromboembolic",
"pulmonary",
"hypertension",
"(CTEPH)",
"by",
"retrospectively",
"evaluating",
"coronary",
"angiograms",
"of",
"eligible",
"consecutive",
"patients",
"who",
"had",
"undergone",
"pulmonary",
"endarterectomy",
"(PEA).",
"We",
"also",
"aimed",
"to",
"evaluate",
"predictors",
"and",
"potential",
"clinical",
"associates",
"of",
"these",
"collaterals.",
"Methods",
"Coronary",
"angiograms",
"of",
"83",
"consecutive",
"CTEPH",
"patients",
"who",
"had",
"undergone",
"coronary",
"angiography",
"before",
"PEA",
"operation",
"between",
"January",
"1,",
"2012",
"and",
"June",
"1,",
"2015",
"were",
"retrospectively",
"evaluated",
"for",
"presence",
"of",
"coronary",
"artery",
"-",
"pulmonary",
"artery",
"collaterals.",
"Medical",
"records",
"of",
"all",
"patients",
"were",
"also",
"retrospectively",
"reviewed",
"for",
"demographic",
"information,",
"cardiovascular",
"risk",
"factors,",
"preoperative",
"right",
"heart",
"catheterization",
"reports,",
"operation",
"reports,",
"and",
"follow-up",
"data.",
"Data",
"of",
"CTEPH",
"patients",
"with",
"coronary",
"artery",
"-",
"pulmonary",
"artery",
"collaterals",
"were",
"compared",
"with",
"data",
"of",
"CTEPH",
"patients",
"without",
"such",
"collaterals.",
"Results",
"There",
"were",
"15",
"patients",
"(18.1%)",
"with",
"definite",
"and",
"4",
"patients",
"(4.8%)",
"with",
"probable",
"coronary",
"artery",
"-",
"pulmonary",
"artery",
"collaterals",
"among",
"the",
"study",
"population.",
"CTEPH",
"patients",
"with",
"collaterals",
"had",
"higher",
"preoperative",
"pulmonary",
"artery",
"pressures,",
"higher",
"pulmonary",
"vascular",
"resistance",
"(PVR)",
"and",
"lower",
"cardiac",
"index",
"values",
"compared",
"with",
"CTEPH",
"patients",
"without",
"collaterals.",
"However,",
"CTEPH",
"patients",
"with",
"collaterals",
"displayed",
"higher",
"amount",
"of",
"reduction",
"in",
"PVR",
"after",
"PEA",
"compared",
"with",
"patients",
"without",
"collaterals.",
"There",
"were",
"no",
"significant",
"differences",
"between",
"groups",
"regarding",
"incidence",
"of",
"reperfusion",
"injury",
"or",
"mortality.",
"Conclusion",
"Prevalence",
"of",
"coronary",
"artery",
"-",
"pulmonary",
"artery",
"collaterals",
"seems",
"to",
"be",
"increased",
"in",
"our",
"CTEPH",
"patients",
"compared",
"with",
"the",
"general",
"population.",
"The",
"presence",
"of",
"coronary",
"artery",
"-",
"pulmonary",
"artery",
"collaterals",
"is",
"often",
"combined",
"with",
"proximal",
"disease",
"with",
"the",
"possibility",
"of",
"increased",
"reduction",
"of",
"PVR",
"after",
"PEA",
"operation."
] | [
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[
"The",
"integration",
"of",
"cyanide",
"hydratase",
"and",
"tyrosinase",
"catalysts",
"enables",
"effective",
"degradation",
"of",
"cyanide",
"and",
"phenol",
"in",
"coking",
"wastewaters",
"The",
"aim",
"of",
"this",
"study",
"was",
"to",
"design",
"an",
"effective",
"method",
"for",
"the",
"bioremediation",
"of",
"coking",
"wastewaters,",
"specifically",
"for",
"the",
"concurrent",
"elimination",
"of",
"their",
"highly",
"toxic",
"components",
"-",
"cyanide",
"and",
"phenols.",
"Almost",
"full",
"degradation",
"of",
"free",
"cyanide",
"(0.32-20",
"mM;",
"8.3-520",
"mg",
"L(-1))",
"in",
"the",
"model",
"and",
"the",
"real",
"coking",
"wastewaters",
"was",
"achieved",
"by",
"using",
"a",
"recombinant",
"cyanide",
"hydratase",
"in",
"the",
"first",
"step.",
"The",
"removal",
"of",
"cyanide,",
"a",
"strong",
"inhibitor",
"of",
"tyrosinase,",
"enabled",
"an",
"effective",
"degradation",
"of",
"phenols",
"by",
"this",
"enzyme",
"in",
"the",
"second",
"step.",
"Phenol",
"(16.5",
"mM,",
"1,552",
"mg",
"L(-1))",
"was",
"completely",
"removed",
"from",
"a",
"real",
"coking",
"wastewater",
"within",
"20",
"h",
"and",
"cresols",
"(5.0",
"mM,",
"540",
"mg",
"L(-1))",
"were",
"removed",
"by",
"66%",
"under",
"the",
"same",
"conditions.",
"The",
"integration",
"of",
"cyanide",
"hydratase",
"and",
"tyrosinase",
"open",
"up",
"new",
"possibilities",
"for",
"the",
"bioremediation",
"of",
"wastewaters",
"with",
"complex",
"pollution."
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[
"MiR-4638-5p",
"inhibits",
"castration",
"resistance",
"of",
"prostate",
"cancer",
"through",
"repressing",
"Kidins220",
"expression",
"and",
"PI3K/AKT",
"pathway",
"activity",
"MicroRNAs",
"(miRNAs)",
"are",
"short,",
"conserved",
"segments",
"of",
"non-coding",
"RNA",
"which",
"play",
"a",
"significant",
"role",
"in",
"prostate",
"cancer",
"development",
"and",
"progression.",
"To",
"identify",
"miRNAs",
"associated",
"with",
"castration",
"resistance,",
"we",
"performed",
"miRNA",
"microarray",
"analysis",
"comparing",
"castration",
"resistant",
"prostate",
"cancer",
"(CRPC)",
"with",
"androgen",
"dependent",
"prostate",
"cancer",
"(ADPC).",
"We",
"identified",
"common",
"underexpression",
"of",
"miR-4638-5p",
"in",
"CRPC",
"compared",
"to",
"ADPC",
"samples,",
"which",
"were",
"further",
"confirmed",
"by",
"quantitative",
"PCR",
"analysis.",
"The",
"role",
"of",
"miR-4638-5p",
"in",
"prostate",
"cancer",
"androgen-independent",
"growth",
"has",
"been",
"demonstrated",
"both",
"in",
"vitro",
"and",
"in",
"vivo.",
"We",
"also",
"identified",
"Kidins220",
"as",
"a",
"target",
"gene",
"directly",
"regulated",
"by",
"miR-4638-5p",
"and",
"shRNA",
"-mediated",
"knockdown",
"of",
"Kidins220",
"phenocopied",
"miR-4638-5p",
"restoration.",
"Subsequently,",
"we",
"revealed",
"that",
"Kidins220",
"activates",
"PI3K/AKT",
"pathway,",
"which",
"plays",
"a",
"key",
"role",
"in",
"CRPC.",
"Loss",
"of",
"miR-",
"4638-5p",
"may",
"lead",
"to",
"CRPC",
"through",
"the",
"activity",
"of",
"Kidins220",
"and",
"PI3K/AKT",
"pathway.",
"Furthermore,",
"we",
"found",
"that",
"miR-4638-5p,",
"through",
"regulating",
"Kidins220",
"and",
"the",
"downstream",
"activity",
"of",
"VEGF",
"and",
"PI3K/AKT",
"pathway,",
"influences",
"prostate",
"cancer",
"progression",
"via",
"angiogenesis.",
"The",
"identification",
"of",
"miR-4638-5p",
"down-regulation",
"in",
"CRPC",
"and",
"the",
"understanding",
"of",
"the",
"functional",
"role",
"of",
"miR-4638-5p",
"and",
"its",
"downstream",
"genes",
"/",
"pathways",
"have",
"the",
"potential",
"to",
"develop",
"biomarkers",
"for",
"CRPC",
"onset",
"and",
"to",
"identify",
"novel",
"targets",
"for",
"novel",
"forms",
"of",
"treatments",
"of",
"this",
"lethal",
"form",
"of",
"PCa."
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[
"Comparison",
"of",
"the",
"Antibacterial",
"Effect",
"of",
"810",
"nm",
"Diode",
"Laser",
"and",
"Photodynamic",
"Therapy",
"in",
"Reducing",
"the",
"Microbial",
"Flora",
"of",
"Root",
"Canal",
"in",
"Endodontic",
"Retreatment",
"in",
"Patients",
"With",
"Periradicular",
"Lesions",
"The",
"aim",
"of",
"this",
"study",
"was",
"to",
"compare",
"the",
"antibacterial",
"efficacy",
"of",
"diode",
"laser",
"810nm",
"and",
"photodynamic",
"therapy",
"(PDT)",
"in",
"reducing",
"bacterial",
"microflora",
"in",
"endodontic",
"retreatment",
"of",
"teeth",
"with",
"periradicular",
"lesion.",
"In",
"this",
"in",
"vivo",
"clinical",
"trial,",
"20",
"patients",
"who",
"needed",
"endodontic",
"retreatment",
"were",
"selected.",
"After",
"conventional",
"chemo",
"mechanical",
"preparation",
"of",
"root",
"canals,",
"microbiological",
"samples",
"were",
"taken",
"with",
"sterile",
"paper",
"point",
"(PP),",
"held",
"in",
"thioglycollate",
"broth,",
"and",
"then",
"were",
"transferred",
"to",
"the",
"microbiological",
"lab.",
"In",
"the",
"first",
"group,",
"PDT",
"with",
"methylene",
"blue",
"(MB)",
"and",
"diode",
"laser",
"(810",
"nm,",
"0.2",
"W,",
"40",
"seconds)",
"was",
"performed",
"and",
"in",
"the",
"second",
"group",
"diode",
"laser",
"(810",
"nm,",
"1.2",
"W,",
"30",
"seconds)",
"was",
"irradiated.",
"Then",
"second",
"samples",
"were",
"taken",
"from",
"all",
"canals.",
"CFU/ml",
"amounts",
"showed",
"statistically",
"significant",
"reduction",
"in",
"both",
"groups",
"(P",
"<",
"0.001).",
"CFU/ml",
"amounts",
"were",
"compared",
"between",
"the",
"two",
"groups",
"and",
"there",
"was",
"no",
"statistical",
"difference.",
"PDT",
"and",
"diode",
"laser",
"810",
"nm",
"irradiation",
"are",
"effective",
"methods",
"for",
"root",
"canal",
"disinfection.",
"PDT",
"is",
"a",
"suitable",
"alternative",
"for",
"diode",
"laser",
"810",
"nm",
"irradiation,",
"because",
"of",
"lower",
"thermal",
"risk",
"on",
"root",
"dentin."
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[
"A",
"comparative",
"analysis",
"of",
"lncRNAs",
"in",
"prostate",
"cancer",
"exosomes",
"and",
"their",
"parental",
"cell",
"lines",
"Prostate",
"cancer",
"is",
"the",
"second",
"leading",
"cancer",
"in",
"men",
"world",
"-",
"wide.",
"Due",
"to",
"its",
"heterogeneous",
"nature,",
"a",
"considerable",
"amount",
"of",
"research",
"effort",
"has",
"been",
"dedicated",
"in",
"identifying",
"effective",
"clinical",
"biomarkers",
"with",
"a",
"focus",
"on",
"proteins,",
"messenger",
"RNA",
"and",
"microRNAs",
"[1].",
"However,",
"there",
"is",
"limited",
"data",
"on",
"the",
"role",
"and",
"expression",
"of",
"long",
"noncoding",
"RNAs",
"(lncRNAs)",
"in",
"prostate",
"cancer",
"exosomes",
"[2].",
"This",
"array",
"dataset",
"which",
"is",
"linked",
"to",
"our",
"publication",
"describes",
"the",
"profiling",
"of",
"human",
"lncRNAs",
"in",
"prostate",
"cancer",
"and",
"their",
"exosomes",
"from",
"five",
"different",
"cell",
"lines",
"[3].",
"From",
"this",
"dataset,",
"we",
"identified",
"a",
"list",
"of",
"statistically",
"significant",
"prostate",
"cancer",
"lncRNAs",
"which",
"are",
"differentially",
"expressed",
"in",
"the",
"exosomes",
"compared",
"to",
"their",
"parent",
"cell",
"lines.",
"This",
"dataset",
"has",
"been",
"deposited",
"into",
"Gene",
"Expression",
"Omnibus",
"(GSE81034)."
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[
"Differential",
"Apoptosis",
"Radiosensitivity",
"of",
"Neural",
"Progenitors",
"in",
"Adult",
"Mouse",
"Hippocampus",
"Mammalian",
"tissue-specific",
"stem",
"cells",
"and",
"progenitors",
"demonstrate",
"differential",
"DNA",
"damage",
"response.",
"Neural",
"progenitors",
"in",
"dentate",
"gyrus",
"of",
"the",
"hippocampus",
"are",
"known",
"to",
"undergo",
"apoptosis",
"after",
"irradiation.",
"Using",
"a",
"mouse",
"model",
"of",
"hippocampal",
"neuronal",
"development,",
"we",
"characterized",
"the",
"apoptosis",
"sensitivity",
"of",
"the",
"different",
"neural",
"progenitor",
"subpopulations",
"in",
"adult",
"mouse",
"dentate",
"gyrus",
"after",
"irradiation.",
"Two",
"different",
"bromodeoxyuridine",
"incorporation",
"paradigms",
"were",
"used",
"for",
"cell",
"fate",
"mapping.",
"We",
"identified",
"two",
"apoptosis",
"sensitive",
"neural",
"progenitor",
"subpopulations",
"after",
"irradiation.",
"The",
"first",
"represented",
"non-proliferative",
"and",
"non-newborn",
"neuroblasts",
"and",
"immature",
"neurons",
"that",
"expressed",
"doublecortin,",
"calretinin",
"or",
"both.",
"The",
"second",
"consisted",
"of",
"proliferative",
"intermediate",
"neural",
"progenitors.",
"The",
"putative",
"radial",
"glia-like",
"neural",
"stem",
"cells",
"or",
"type-1",
"cells,",
"regardless",
"of",
"proliferation",
"status,",
"were",
"apoptosis",
"resistant",
"after",
"irradiation.",
"There",
"was",
"no",
"evidence",
"of",
"radiation",
"-",
"induced",
"apoptosis",
"in",
"the",
"absence",
"of",
"the",
"Trp53",
"(p53)",
"gene",
"but",
"absence",
"of",
"Cdkn1a",
"(p21)",
"did",
"not",
"alter",
"the",
"apoptotic",
"response.",
"Upregulation",
"of",
"nuclear",
"p53",
"was",
"observed",
"in",
"neuroblasts",
"after",
"irradiation.",
"We",
"conclude",
"that",
"adult",
"hippocampal",
"neural",
"progenitors",
"may",
"demonstrate",
"differential",
"p53",
"-dependent",
"apoptosis",
"sensitivity",
"after",
"irradiation."
] | [
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[
"Information",
"Literacy",
"in",
"a",
"Digital",
"Era:",
"Understanding",
"the",
"Impact",
"of",
"Mobile",
"Information",
"for",
"Undergraduate",
"Nursing",
"Students",
"Recent",
"entry",
"-to-",
"practice",
"nursing",
"informatics",
"competencies",
"for",
"Registered",
"Nurses",
"in",
"Canada",
"mean",
"nurse",
"educators",
"need",
"educational",
"strategies",
"to",
"promote",
"student",
"competency",
"within",
"the",
"rapidly",
"evolving",
"informatics",
"field.",
"A",
"collaborative",
"research",
"team",
"from",
"three",
"Canadian",
"nursing",
"programs",
"completed",
"a",
"mixed",
"method",
"survey",
"to",
"describe",
"how",
"nursing",
"students",
"used",
"mobile",
"nursing",
"information",
"support",
"and",
"the",
"extent",
"of",
"this",
"support",
"for",
"learning.",
"The",
"Mobile",
"Information",
"Support",
"Evaluation",
"Tool",
"(MISET)",
"assessed",
"Usefulness",
"/",
"Helpfulness,",
"Information",
"Literacy",
"Support,",
"and",
"Use",
"of",
"Evidence",
"-Based",
"Sources.",
"The",
"quantitative",
"and",
"qualitative",
"data",
"were",
"analyzed",
"to",
"describe",
"students'",
"perspectives",
"and",
"the",
"ways",
"they",
"used",
"mobile",
"resources",
"in",
"learning",
"situations.",
"Findings",
"suggest",
"nursing",
"students",
"mainly",
"accessed",
"mobile",
"resources",
"to",
"support",
"clinical",
"learning,",
"and",
"specifically",
"for",
"task",
"-",
"oriented",
"information",
"such",
"as",
"drug",
"medication",
"or",
"patient",
"conditions/diagnoses.",
"Researchers",
"recommend",
"a",
"paradigm",
"shift",
"whereby",
"educators",
"emphasize",
"information",
"literacy",
"in",
"a",
"way",
"that",
"supports",
"evidence",
"-based",
"quality",
"care."
] | [
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[
"Improving",
"EMR",
"Usability:",
"Critical",
"Elements",
"When",
"Designing",
"Perioperative",
"Emergencies",
"Template",
"Perianesthesia",
"nursing",
"care",
"involves",
"monitoring",
"of",
"unexpected",
"outcomes",
"before",
"and",
"after",
"surgical",
"and",
"anesthetic",
"procedures.",
"When",
"adverse",
"events",
"occur,",
"reviewing",
"patient",
"data",
"is",
"critical",
"to",
"provide",
"appropriate",
"intervention.",
"Current",
"EMR",
"software",
"systems",
"are",
"limited",
"in",
"structure",
"and",
"are",
"not",
"cohesive",
"in",
"recording",
"adverse",
"events.",
"Users",
"tend",
"to",
"develop",
"workarounds",
"when",
"systems",
"fail",
"to",
"capture",
"workflow.",
"Analysis",
"of",
"adverse",
"incident",
"is",
"incomplete",
"because",
"data",
"entered",
"is",
"not",
"retrievable.",
"Narrative",
"data,",
"while",
"sometimes",
"necessary,",
"cannot",
"easily",
"be",
"analyzed",
"or",
"linked",
"to",
"the",
"structured",
"portion",
"of",
"the",
"record.",
"Designing",
"templates",
"to",
"capture",
"essential",
"data",
"during",
"emergency",
"situations",
"improves",
"usability",
"and",
"compliance.",
"The",
"presentation",
"of",
"information",
"in",
"terms",
"of",
"layout",
"and",
"structure",
"is",
"important",
"because",
"it",
"can",
"influence",
"data",
"retrieval,",
"interpretation",
"and",
"clinical",
"decision",
"making",
"in",
"fundamental",
"ways."
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[
"Sewage",
"sludge",
"pretreatment",
"by",
"microwave",
"irradiation",
"combined",
"with",
"activated",
"carbon",
"fibre",
"at",
"alkaline",
"pH",
"for",
"anaerobic",
"digestion",
"This",
"research",
"focuses",
"on",
"the",
"effects",
"of",
"microwave",
"-assisted",
"activated",
"carbon",
"fibre",
"(ACF)",
"(MW",
"-",
"ACF)",
"treatment",
"on",
"sewage",
"sludge",
"at",
"alkaline",
"pH.",
"The",
"disintegration",
"and",
"biodegradability",
"of",
"sewage",
"sludge",
"were",
"studied.",
"It",
"was",
"found",
"that",
"the",
"MW-ACF",
"process",
"at",
"alkaline",
"pH",
"provided",
"a",
"rapid",
"and",
"efficient",
"process",
"to",
"disrupt",
"the",
"microbial",
"cells",
"in",
"the",
"sludge.",
"The",
"results",
"suggested",
"that",
"when",
"irradiated",
"at",
"800",
"W",
"MW",
"for",
"110",
"s",
"with",
"a",
"dose",
"of",
"1.0",
"g",
"ACF",
"/g",
"solid",
"concentration",
"(SS)",
"at",
"pH",
"10.5,",
"the",
"MW",
"-",
"ACF",
"pretreatment",
"achieved",
"55%",
"SS",
"disintegration,",
"23%",
"greater",
"than",
"the",
"value",
"of",
"MW",
"alone",
"(32%).",
"The",
"concentration",
"of",
"total",
"nitrogen,",
"total",
"phosphorus,",
"supernatant",
"soluble",
"chemical",
"oxygen",
"demand,",
"protein,",
"and",
"polysaccharide",
"increased",
"by",
"60%,",
"144%,",
"145%,",
"74%,",
"and",
"77%,",
"respectively.",
"An",
"increase",
"in",
"biogas",
"production",
"by",
"63.7%",
"was",
"achieved",
"after",
"20",
"days",
"of",
"anaerobic",
"digestion",
"(AD),",
"compared",
"to",
"the",
"control.",
"The",
"results",
"indicated",
"that",
"the",
"MW-ACF",
"pretreatment",
"process",
"at",
"alkaline",
"pH",
"provides",
"novel",
"sludge",
"management",
"options",
"in",
"disintegration",
"of",
"sewage",
"sludge",
"for",
"further",
"AD."
] | [
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[
"The",
"Effects",
"of",
"Sequential",
"Environmental",
"and",
"Harvest",
"Stressors",
"on",
"the",
"Sensory",
"Characteristics",
"of",
"Cultured",
"Channel",
"Catfish",
"(Ictalurus",
"Punctatus)",
"Fillets",
"Stress",
"during",
"fish",
"culture",
"alters",
"physiological",
"homeostasis",
"and",
"affects",
"fillet",
"quality.",
"Maintenance",
"of",
"high-",
"quality",
"seafood",
"is",
"important",
"to",
"ensure",
"the",
"production",
"of",
"a",
"marketable",
"product.",
"This",
"study",
"assessed",
"how",
"sequential",
"stressors",
"affect",
"the",
"sensory",
"and",
"quality",
"characteristics",
"of",
"catfish",
"(Ictalurus",
"punctatus)",
"fillets.",
"Three",
"stress",
"trials",
"were",
"conducted",
"where",
"temperature",
"(25",
"or",
"33",
"°C)",
"and",
"dissolved",
"oxygen",
"(DO,",
"approximately",
"2.5",
"or",
">5",
"mg/L)",
"were",
"manipulated",
"followed",
"by",
"socking",
"and",
"transport",
"stress.",
"After",
"each",
"stage",
"of",
"harvest",
"(environmental",
"stress,",
"socking,",
"and",
"transport),",
"fillet",
"yield,",
"consumer",
"acceptability,",
"descriptive",
"evaluation,",
"cook",
"loss,",
"tenderness,",
"and",
"pH",
"were",
"evaluated.",
"Fillet",
"yield",
"decreased",
"with",
"increasing",
"severity",
"of",
"environmental",
"stress.",
"Fillets",
"from",
"the",
"severe",
"stress",
"treatment",
"(33",
"°C,",
"approximately",
"2.5",
"mg/L)",
"received",
"the",
"highest",
"acceptability",
"scores",
"(P",
"<",
"0.05).",
"Control",
"fillets",
"(25",
"°C,",
">5",
"mg/L)",
"were",
"the",
"least",
"acceptable",
"(P",
"<",
"0.05).",
"Increased",
"intensity",
"of",
"less",
"favorable",
"flavor",
"attributes",
"commonly",
"associated",
"with",
"catfish",
"resulted",
"in",
"the",
"differences",
"in",
"acceptability",
"among",
"treatments.",
"As",
"fish",
"progressed",
"through",
"the",
"harvest",
"event,",
"cook",
"loss",
"decreased,",
"tenderness",
"increased,",
"and",
"pH",
"increased,",
"indicating",
"that",
"stress",
"induced",
"textural",
"changes.",
"The",
"data",
"suggest",
"that",
"although",
"environmental",
"stress",
"results",
"in",
"slight",
"changes",
"in",
"flavor",
"attributes,",
"its",
"effects",
"on",
"acceptability",
"are",
"minor",
"with",
"fillets",
"from",
"all",
"treatments",
"still",
"liked",
"(>6",
"on",
"a",
"9",
"point",
"scale).",
"Socking",
"and",
"transport",
"were",
"identified",
"to",
"positively",
"affect",
"textural",
"characteristics",
"of",
"catfish",
"fillets.",
"Although",
"the",
"effects",
"observed",
"were",
"not",
"likely",
"to",
"negatively",
"impact",
"consumer",
"acceptance,",
"a",
"strict",
"management",
"plan",
"should",
"be",
"followed",
"to",
"maintain",
"consistency",
"in",
"the",
"product",
"and",
"avoid",
"changes",
"in",
"stressors",
"that",
"might",
"alter",
"quality",
"more",
"drastically."
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